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Conserved domains on  [gi|568913744|ref|XP_006498129|]
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origin recognition complex subunit 4 isoform X2 [Mus musculus]

Protein Classification

origin recognition complex subunit 4( domain architecture ID 13386334)

origin recognition complex subunit 4 is a component of the origin recognition complex (ORC), an ATP-dependent DNA-binding complex that binds origins of replication

CATH:  3.40.50.300
Gene Symbol:  ORC4
Gene Ontology:  GO:0006270|GO:0006260|GO:0005524|GO:0000808|GO:0003688
PubMed:  20130679|18208389|18466635|16828312|15037233|17241905
SCOP:  4000172|4000283

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ORC4_C pfam14629
Origin recognition complex (ORC) subunit 4 C-terminus; This entry represents the C-terminus of ...
 195-354 1.99e-50

Origin recognition complex (ORC) subunit 4 C-terminus; This entry represents the C-terminus of origin recognition complex subunit 4.


:

Pssm-ID: 464223  Cd Length: 212  Bit Score: 167.90  E-value: 1.99e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568913744  195 LSEDSTVLEVLQKHFSVNKNLQSLHMLLMLALNRVTVSHPFMTSADLMEAQHMCSLDSKANIVHGLSVLEICLIIAMKHL 274
Cdd:pfam14629  33 LLEDSTVQDILKRLYYTTKSVRSLLNSLILPVSKLSPDSPLLTAESLLSALSSQSPDSKLSLLRSLSVLELCLLIAAARL 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568913744  275 NDIYEEEPFNFQMVYNEFQKFIQRK-------------AHSVYNFEKPVVMKAFEHLQQLELIKPVERTSVNS------- 334
Cdd:pfam14629 113 SEIYDTDTFNFEMVYDEYKKLAKRSkvspssatsqssaASGIRVWGRPVALKAWEHLLSLELLVPVGAVSTGGassgsgg 192

                         170       180
                  ....*....|....*....|
gi 568913744  335 QREYQLVKLLLDNTQIMNAL 354
Cdd:pfam14629 193 GKEFRMVRLDITLEEIREAV 212
CDC6 super family cl34277
Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair];
41-190 1.75e-13

Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair];


The actual alignment was detected with superfamily member COG1474:

Pssm-ID: 441083 [Multi-domain]  Cd Length: 389  Bit Score: 71.03  E-value: 1.75e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568913744  41 QYKHLIELLkRTAIYGES-NSVLIVGPRGSGKTTLLNHALKELMEI--EVSENVIQVHLNGLLQTNEKIALKEITRQLNL 117
Cdd:COG1474   34 EIEELASAL-RPALRGERpSNVLIYGPTGTGKTAVAKYVLEELEEEaeERGVDVRVVYVNCRQASTRYRVLSRILEELGS 112

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568913744 118 DNVVEDKvfG-SFAENLSFLLEALQKGDRtsscPVIFILDEFDIFAHQKNQTLLYNLFDISQS-AQTPVAVIGLT 190
Cdd:COG1474  113 GEDIPST--GlSTDELFDRLYEALDERDG----VLVVVLDEIDYLVDDEGDDLLYQLLRANEElEGARVGVIGIS 181
 
Name Accession Description Interval E-value
ORC4_C pfam14629
Origin recognition complex (ORC) subunit 4 C-terminus; This entry represents the C-terminus of ...
 195-354 1.99e-50

Origin recognition complex (ORC) subunit 4 C-terminus; This entry represents the C-terminus of origin recognition complex subunit 4.


Pssm-ID: 464223  Cd Length: 212  Bit Score: 167.90  E-value: 1.99e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568913744  195 LSEDSTVLEVLQKHFSVNKNLQSLHMLLMLALNRVTVSHPFMTSADLMEAQHMCSLDSKANIVHGLSVLEICLIIAMKHL 274
Cdd:pfam14629  33 LLEDSTVQDILKRLYYTTKSVRSLLNSLILPVSKLSPDSPLLTAESLLSALSSQSPDSKLSLLRSLSVLELCLLIAAARL 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568913744  275 NDIYEEEPFNFQMVYNEFQKFIQRK-------------AHSVYNFEKPVVMKAFEHLQQLELIKPVERTSVNS------- 334
Cdd:pfam14629 113 SEIYDTDTFNFEMVYDEYKKLAKRSkvspssatsqssaASGIRVWGRPVALKAWEHLLSLELLVPVGAVSTGGassgsgg 192

                         170       180
                  ....*....|....*....|
gi 568913744  335 QREYQLVKLLLDNTQIMNAL 354
Cdd:pfam14629 193 GKEFRMVRLDITLEEIREAV 212
CDC6 COG1474
Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair];
41-190 1.75e-13

Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair];


Pssm-ID: 441083 [Multi-domain]  Cd Length: 389  Bit Score: 71.03  E-value: 1.75e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568913744  41 QYKHLIELLkRTAIYGES-NSVLIVGPRGSGKTTLLNHALKELMEI--EVSENVIQVHLNGLLQTNEKIALKEITRQLNL 117
Cdd:COG1474   34 EIEELASAL-RPALRGERpSNVLIYGPTGTGKTAVAKYVLEELEEEaeERGVDVRVVYVNCRQASTRYRVLSRILEELGS 112

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568913744 118 DNVVEDKvfG-SFAENLSFLLEALQKGDRtsscPVIFILDEFDIFAHQKNQTLLYNLFDISQS-AQTPVAVIGLT 190
Cdd:COG1474  113 GEDIPST--GlSTDELFDRLYEALDERDG----VLVVVLDEIDYLVDDEGDDLLYQLLRANEElEGARVGVIGIS 181
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
 44-192 7.95e-09

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 54.07  E-value: 7.95e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568913744  44 HLIELLKRTAIYGESNSVLIVGPRGSGKTTLLNHALKELmeIEVSENVIQVHLNGLLQTNekialkeitrqlnldnvVED 123
Cdd:cd00009    5 EAIEALREALELPPPKNLLLYGPPGTGKTTLARAIANEL--FRPGAPFLYLNASDLLEGL-----------------VVA 65

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568913744 124 KVFGSFAENLSFLLEALQKGDrtsscpvIFILDEFDIFAHQKNQTLLYNL--FDISQSAQTPVAVIGLTCR 192
Cdd:cd00009   66 ELFGHFLVRLLFELAEKAKPG-------VLFIDEIDSLSRGAQNALLRVLetLNDLRIDRENVRVIGATNR 129
cdc6 PRK00411
ORC1-type DNA replication protein;
46-205 1.79e-08

ORC1-type DNA replication protein;


Pssm-ID: 234751 [Multi-domain]  Cd Length: 394  Bit Score: 55.62  E-value: 1.79e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568913744  46 IELLK---RTAIYGESNS-VLIVGPRGSGKTTLLNHALKELMEIevSENVIQVHLNGLLQTNEKIALKEITRQLNLDNVV 121
Cdd:PRK00411  39 IEELAfalRPALRGSRPLnVLIYGPPGTGKTTTVKKVFEELEEI--AVKVVYVYINCQIDRTRYAIFSEIARQLFGHPPP 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568913744 122 EDKVfgSFAENLSFLLEALQKGDRTsscpVIFILDEFDIFAHQKNQTLLYNLFDISQsaQTPVAVIGLtcrLCLSEDSTV 201
Cdd:PRK00411 117 SSGL--SFDELFDKIAEYLDERDRV----LIVALDDINYLFEKEGNDVLYSLLRAHE--EYPGARIGV---IGISSDLTF 185


                 ....
gi 568913744 202 LEVL 205
Cdd:PRK00411 186 LYIL 189
AAA_16 pfam13191
AAA ATPase domain; This family of domains contain a P-loop motif that is characteriztic of the ...
 34-187 4.71e-08

AAA ATPase domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily.


Pssm-ID: 433025 [Multi-domain]  Cd Length: 167  Bit Score: 52.12  E-value: 4.71e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568913744   34 NLFGVQVQYKHLIELLKRTAIyGESNSVLIVGPRGSGKTTLLNHALKEL-------MEIEVSENVIQVHLNGLLQTN--- 103
Cdd:pfam13191   1 RLVGREEELEQLLDALDRVRS-GRPPSVLLTGEAGTGKTTLLRELLRALerdggyfLRGKCDENLPYSPLLEALTREgll 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568913744  104 EKIALKEITRQLNLDNVVEDKVFGSFAE----NLSFLLEALQK---GDRTSSCPVIFILDEFDIFAHQkNQTLLYNLFDI 176
Cdd:pfam13191  80 RQLLDELESSLLEAWRAALLEALAPVPElpgdLAERLLDLLLRlldLLARGERPLVLVLDDLQWADEA-SLQLLAALLRL 158

                         170
                  ....*....|.
gi 568913744  177 SQsaQTPVAVI 187
Cdd:pfam13191 159 LE--SLPLLVV 167
TIGR02928 TIGR02928
orc1/cdc6 family replication initiation protein; Members of this protein family are found ...
 56-190 9.12e-07

orc1/cdc6 family replication initiation protein; Members of this protein family are found exclusively in the archaea. This set of DNA binding proteins shows homology to the origin recognition complex subunit 1/cell division control protein 6 family in eukaryotes. Several members may be found in genome and interact with each other. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 274354 [Multi-domain]  Cd Length: 365  Bit Score: 50.32  E-value: 9.12e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568913744   56 GESNSVLIVGPRGSGKTTLLNHALKELMEI--EVSENVIQVHLNGLLQTNEKIALKEITRQLNldnVVEDKV--FG-SFA 130
Cdd:TIGR02928  38 SRPSNVFIYGKTGTGKTAVTKYVMKELEEAaeDRDVRVVTVYVNCQILDTLYQVLVELANQLR---GSGEEVptTGlSTS 114

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568913744  131 ENLSFLLEALQKGDRTsscpVIFILDEFDIFAhQKNQTLLYNLFDISQSAQT---PVAVIGLT 190
Cdd:TIGR02928 115 EVFRRLYKELNERGDS----LIIVLDEIDYLV-GDDDDLLYQLSRARSNGDLdnaKVGVIGIS 172
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 59-190 7.01e-06

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 45.44  E-value: 7.01e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568913744    59 NSVLIVGPRGSGKTTLLNHALKELmeIEVSENVIQVHLNGLLQtnekialkEITRQLNLDNVVEDKVFGSFAENLSFLLE 138
Cdd:smart00382   3 EVILIVGPPGSGKTTLARALAREL--GPPGGGVIYIDGEDILE--------EVLDQLLLIIVGGKKASGSGELRLRLALA 72

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 568913744   139 ALQKgdrtsSCPVIFILDEF----DIFAHQKNQTLLYNLFDISQSAQTPVAVIGLT 190
Cdd:smart00382  73 LARK-----LKPDVLILDEItsllDAEQEALLLLLEELRLLLLLKSEKNLTVILTT 123
 
Name Accession Description Interval E-value
ORC4_C pfam14629
Origin recognition complex (ORC) subunit 4 C-terminus; This entry represents the C-terminus of ...
 195-354 1.99e-50

Origin recognition complex (ORC) subunit 4 C-terminus; This entry represents the C-terminus of origin recognition complex subunit 4.


Pssm-ID: 464223  Cd Length: 212  Bit Score: 167.90  E-value: 1.99e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568913744  195 LSEDSTVLEVLQKHFSVNKNLQSLHMLLMLALNRVTVSHPFMTSADLMEAQHMCSLDSKANIVHGLSVLEICLIIAMKHL 274
Cdd:pfam14629  33 LLEDSTVQDILKRLYYTTKSVRSLLNSLILPVSKLSPDSPLLTAESLLSALSSQSPDSKLSLLRSLSVLELCLLIAAARL 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568913744  275 NDIYEEEPFNFQMVYNEFQKFIQRK-------------AHSVYNFEKPVVMKAFEHLQQLELIKPVERTSVNS------- 334
Cdd:pfam14629 113 SEIYDTDTFNFEMVYDEYKKLAKRSkvspssatsqssaASGIRVWGRPVALKAWEHLLSLELLVPVGAVSTGGassgsgg 192

                         170       180
                  ....*....|....*....|
gi 568913744  335 QREYQLVKLLLDNTQIMNAL 354
Cdd:pfam14629 193 GKEFRMVRLDITLEEIREAV 212
CDC6 COG1474
Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair];
41-190 1.75e-13

Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair];


Pssm-ID: 441083 [Multi-domain]  Cd Length: 389  Bit Score: 71.03  E-value: 1.75e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568913744  41 QYKHLIELLkRTAIYGES-NSVLIVGPRGSGKTTLLNHALKELMEI--EVSENVIQVHLNGLLQTNEKIALKEITRQLNL 117
Cdd:COG1474   34 EIEELASAL-RPALRGERpSNVLIYGPTGTGKTAVAKYVLEELEEEaeERGVDVRVVYVNCRQASTRYRVLSRILEELGS 112

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568913744 118 DNVVEDKvfG-SFAENLSFLLEALQKGDRtsscPVIFILDEFDIFAHQKNQTLLYNLFDISQS-AQTPVAVIGLT 190
Cdd:COG1474  113 GEDIPST--GlSTDELFDRLYEALDERDG----VLVVVLDEIDYLVDDEGDDLLYQLLRANEElEGARVGVIGIS 181
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
 44-192 7.95e-09

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 54.07  E-value: 7.95e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568913744  44 HLIELLKRTAIYGESNSVLIVGPRGSGKTTLLNHALKELmeIEVSENVIQVHLNGLLQTNekialkeitrqlnldnvVED 123
Cdd:cd00009    5 EAIEALREALELPPPKNLLLYGPPGTGKTTLARAIANEL--FRPGAPFLYLNASDLLEGL-----------------VVA 65

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568913744 124 KVFGSFAENLSFLLEALQKGDrtsscpvIFILDEFDIFAHQKNQTLLYNL--FDISQSAQTPVAVIGLTCR 192
Cdd:cd00009   66 ELFGHFLVRLLFELAEKAKPG-------VLFIDEIDSLSRGAQNALLRVLetLNDLRIDRENVRVIGATNR 129
cdc6 PRK00411
ORC1-type DNA replication protein;
46-205 1.79e-08

ORC1-type DNA replication protein;


Pssm-ID: 234751 [Multi-domain]  Cd Length: 394  Bit Score: 55.62  E-value: 1.79e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568913744  46 IELLK---RTAIYGESNS-VLIVGPRGSGKTTLLNHALKELMEIevSENVIQVHLNGLLQTNEKIALKEITRQLNLDNVV 121
Cdd:PRK00411  39 IEELAfalRPALRGSRPLnVLIYGPPGTGKTTTVKKVFEELEEI--AVKVVYVYINCQIDRTRYAIFSEIARQLFGHPPP 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568913744 122 EDKVfgSFAENLSFLLEALQKGDRTsscpVIFILDEFDIFAHQKNQTLLYNLFDISQsaQTPVAVIGLtcrLCLSEDSTV 201
Cdd:PRK00411 117 SSGL--SFDELFDKIAEYLDERDRV----LIVALDDINYLFEKEGNDVLYSLLRAHE--EYPGARIGV---IGISSDLTF 185


                 ....
gi 568913744 202 LEVL 205
Cdd:PRK00411 186 LYIL 189
COG1672 COG1672
Predicted ATPase, archaeal AAA+ ATPase superfamily [General function prediction only];
46-158 4.66e-08

Predicted ATPase, archaeal AAA+ ATPase superfamily [General function prediction only];


Pssm-ID: 441278 [Multi-domain]  Cd Length: 324  Bit Score: 54.15  E-value: 4.66e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568913744  46 IELLKRTAIYGESNSVLIVGPRGSGKTTLLNHALKELMEIEVSenviqvhlngLLQTNEKIALKEITRQLN--LDNVVED 123
Cdd:COG1672    9 LEELEKLYESDGGELVVVYGRRRVGKTSLIKEFLKEKPAIYFD----------AREESERESLRDFSEALAeaLGDPLSK 78

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 568913744 124 KVFGSFAENLSFLLEALQKGdrtsscPVIFILDEF 158
Cdd:COG1672   79 KEFESWEEAFEYLAELAEGK------RLVIVIDEF 107
AAA_16 pfam13191
AAA ATPase domain; This family of domains contain a P-loop motif that is characteriztic of the ...
 34-187 4.71e-08

AAA ATPase domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily.


Pssm-ID: 433025 [Multi-domain]  Cd Length: 167  Bit Score: 52.12  E-value: 4.71e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568913744   34 NLFGVQVQYKHLIELLKRTAIyGESNSVLIVGPRGSGKTTLLNHALKEL-------MEIEVSENVIQVHLNGLLQTN--- 103
Cdd:pfam13191   1 RLVGREEELEQLLDALDRVRS-GRPPSVLLTGEAGTGKTTLLRELLRALerdggyfLRGKCDENLPYSPLLEALTREgll 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568913744  104 EKIALKEITRQLNLDNVVEDKVFGSFAE----NLSFLLEALQK---GDRTSSCPVIFILDEFDIFAHQkNQTLLYNLFDI 176
Cdd:pfam13191  80 RQLLDELESSLLEAWRAALLEALAPVPElpgdLAERLLDLLLRlldLLARGERPLVLVLDDLQWADEA-SLQLLAALLRL 158

                         170
                  ....*....|.
gi 568913744  177 SQsaQTPVAVI 187
Cdd:pfam13191 159 LE--SLPLLVV 167
TIGR02928 TIGR02928
orc1/cdc6 family replication initiation protein; Members of this protein family are found ...
 56-190 9.12e-07

orc1/cdc6 family replication initiation protein; Members of this protein family are found exclusively in the archaea. This set of DNA binding proteins shows homology to the origin recognition complex subunit 1/cell division control protein 6 family in eukaryotes. Several members may be found in genome and interact with each other. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 274354 [Multi-domain]  Cd Length: 365  Bit Score: 50.32  E-value: 9.12e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568913744   56 GESNSVLIVGPRGSGKTTLLNHALKELMEI--EVSENVIQVHLNGLLQTNEKIALKEITRQLNldnVVEDKV--FG-SFA 130
Cdd:TIGR02928  38 SRPSNVFIYGKTGTGKTAVTKYVMKELEEAaeDRDVRVVTVYVNCQILDTLYQVLVELANQLR---GSGEEVptTGlSTS 114

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568913744  131 ENLSFLLEALQKGDRTsscpVIFILDEFDIFAhQKNQTLLYNLFDISQSAQT---PVAVIGLT 190
Cdd:TIGR02928 115 EVFRRLYKELNERGDS----LIIVLDEIDYLV-GDDDDLLYQLSRARSNGDLdnaKVGVIGIS 172
NACHT COG5635
Predicted NTPase, NACHT family domain [Signal transduction mechanisms];
57-192 1.19e-06

Predicted NTPase, NACHT family domain [Signal transduction mechanisms];


Pssm-ID: 444362 [Multi-domain]  Cd Length: 935  Bit Score: 50.57  E-value: 1.19e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568913744  57 ESNSVLIVGPRGSGKTTLLNHALKELMEIEVSENVIQVHLngllqtnekIALKEITRQLNLDNVVEDKVFGSFAENLSFL 136
Cdd:COG5635  179 KKKRLLILGEPGSGKTTLLRYLALELAERYLDAEDPIPIL---------IELRDLAEEASLEDLLAEALEKRGGEPEDAL 249

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 568913744 137 LEALQKGdrtsscPVIFILDEFD-IFAHQKNQTLLYNLFDISQSAQtPVAVIgLTCR 192
Cdd:COG5635  250 ERLLRNG------RLLLLLDGLDeVPDEADRDEVLNQLRRFLERYP-KARVI-ITSR 298
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 59-190 7.01e-06

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 45.44  E-value: 7.01e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568913744    59 NSVLIVGPRGSGKTTLLNHALKELmeIEVSENVIQVHLNGLLQtnekialkEITRQLNLDNVVEDKVFGSFAENLSFLLE 138
Cdd:smart00382   3 EVILIVGPPGSGKTTLARALAREL--GPPGGGVIYIDGEDILE--------EVLDQLLLIIVGGKKASGSGELRLRLALA 72

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 568913744   139 ALQKgdrtsSCPVIFILDEF----DIFAHQKNQTLLYNLFDISQSAQTPVAVIGLT 190
Cdd:smart00382  73 LARK-----LKPDVLILDEItsllDAEQEALLLLLEELRLLLLLKSEKNLTVILTT 123
AAA_22 pfam13401
AAA domain;
60-188 1.35e-05

AAA domain;


Pssm-ID: 379165 [Multi-domain]  Cd Length: 129  Bit Score: 44.25  E-value: 1.35e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568913744   60 SVLIVGPRGSGKTTLlnhaLKELMEIEVSENVIQVHLNGLLQTNEKIALKEITRQLNLDnvvedkvfGSFAENLSFLLEA 139
Cdd:pfam13401   7 ILVLTGESGTGKTTL----LRRLLEQLPEVRDSVVFVDLPSGTSPKDLLRALLRALGLP--------LSGRLSKEELLAA 74

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 568913744  140 LQKGDRTSSCPVIFILDEFDiFAHQKNQTLLYNLFDISQSAqTPVAVIG 188
Cdd:pfam13401  75 LQQLLLALAVAVVLIIDEAQ-HLSLEALEELRDLLNLSSKL-LQLILVG 121
PulE COG2804
Type II secretory pathway ATPase GspE/PulE or T4P pilus assembly pathway ATPase PilB [Cell ...
 61-114 4.43e-05

Type II secretory pathway ATPase GspE/PulE or T4P pilus assembly pathway ATPase PilB [Cell motility, Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 442055 [Multi-domain]  Cd Length: 561  Bit Score: 45.18  E-value: 4.43e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568913744  61 VLIVGPRGSGKTTLLNHALKELMEIEVseNVIQV------HLNGLLQT--NEKI------ALKEITRQ 114
Cdd:COG2804  316 ILVTGPTGSGKTTTLYAALNELNTPER--NIITVedpveyQLPGINQVqvNPKIgltfasALRSILRQ 381
COG1373 COG1373
Predicted ATPase, AAA+ superfamily [General function prediction only];
42-157 1.03e-04

Predicted ATPase, AAA+ superfamily [General function prediction only];


Pssm-ID: 440984 [Multi-domain]  Cd Length: 405  Bit Score: 44.16  E-value: 1.03e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568913744  42 YKHLIELLKRTAIygesnsVLIVGPRGSGKTTLLNHALKELMEIEVsenviqvhlngllqtnekialkeitrqLNLDNvv 121
Cdd:COG1373   10 LDKLLKLLDNRKA------VVITGPRQVGKTTLLKQLAKELENILY---------------------------INLDD-- 54

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 568913744 122 eDKVFGSFAENLSFLLEALQKGDRTsscPVIFILDE 157
Cdd:COG1373   55 -PRLRALAEEDPDDLLEALKELYPG---KTYLFLDE 86
PulE-GspE-like cd01129
PulE-GspE family; PulE and General secretory pathway protein GspE are ATPases of the type II ...
 61-114 1.34e-04

PulE-GspE family; PulE and General secretory pathway protein GspE are ATPases of the type II secretory pathway, the main terminal branch of the general secretory pathway (GSP). PulE is a cytoplasmic protein of the GSP, which contains an ATP binding site and a tetracysteine motif. This subgroup also includes PilB, a type IV pilus assembly ATPase, DotB, an ATPase of the type IVb secretion system, also known as the dot/icm system, Escherichia coli IncI plasmid-encoded conjugative transfer ATPase TraJ, and HofB.


Pssm-ID: 410873 [Multi-domain]  Cd Length: 159  Bit Score: 42.09  E-value: 1.34e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568913744  61 VLIVGPRGSGKTTLLNHALKELMEIEVS----ENVIQVHLNGLLQT--NEKI------ALKEITRQ 114
Cdd:cd01129   14 ILVTGPTGSGKTTTLYAMLRELNGPERNiitiEDPVEYQIPGINQSqvNEKIgltfadALRAILRQ 79
T2SSE pfam00437
Type II/IV secretion system protein; This family contains components of both the Type II ...
 60-143 4.71e-04

Type II/IV secretion system protein; This family contains components of both the Type II protein secretion system (T2SS), including Type 4 pilus (T4P), and Type IV protein secretion system (T4SS) from Gram-negative bacteria. VirB11 ATPase is a subunit of the Agrobacterium tumefaciens transfer DNA (T-DNA) transfer system, a type IV secretion pathway required for delivery of T-DNA and effector proteins to plant cells during infection. The cytoplasmic T2S E ATPase is a Zn-containing protein thought to provide the mechanical force for the secretion process. T2S-E contains Walker A and B motifs, that are essential for secretion and ATPase activity. ATPase PulE and XcpR from Klebsiella oxytoca and Pseudomonas aeruginosa respectively are required for protein secretion via the T2SS. ATPase PilB is required for T4P extension.


Pssm-ID: 425681 [Multi-domain]  Cd Length: 269  Bit Score: 41.50  E-value: 4.71e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568913744   60 SVLIVGPRGSGKTTLLNHALKELMEIEVS----ENVIQVHLNGLLQT--NEKI------ALKEITRQlNLDNVVEDKVFG 127
Cdd:pfam00437 132 NILVTGPTGSGKTTTLYAALGELNTRDENivtvEDPVEIQLEGINQVqlNARAgvtfadLLRAILRQ-DPDRIMVGEIRD 210

                          90
                  ....*....|....*.
gi 568913744  128 sfAENLSFLLEALQKG 143
Cdd:pfam00437 211 --LETAEIALQAANTG 224
AAA_14 pfam13173
AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA ...
 61-157 5.36e-04

AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily.


Pssm-ID: 463799 [Multi-domain]  Cd Length: 128  Bit Score: 39.49  E-value: 5.36e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568913744   61 VLIVGPRGSGKTTLLNHALKELMEievSENVIQVhlngllqtnekialkeitrqlNLDNVVEDKVfgSFAENLSFLLEAL 140
Cdd:pfam13173   5 LVITGPRQVGKTTLLLQLIKELLP---PENILYI---------------------NLDDPRLLKL--ADFELLELFLELL 58

                          90
                  ....*....|....*..
gi 568913744  141 QKGDRtsscpvIFILDE 157
Cdd:pfam13173  59 YPGKT------YLFLDE 69
LolD COG1136
ABC-type lipoprotein export system, ATPase component [Cell wall/membrane/envelope biogenesis];
56-76 1.37e-03

ABC-type lipoprotein export system, ATPase component [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440751 [Multi-domain]  Cd Length: 227  Bit Score: 39.64  E-value: 1.37e-03
                         10        20
                 ....*....|....*....|.
gi 568913744  56 GESnsVLIVGPRGSGKTTLLN 76
Cdd:COG1136   34 GEF--VAIVGPSGSGKSTLLN 52
ABC_MJ0796_LolCDE_FtsE cd03255
ATP-binding cassette domain of the transporters involved in export of lipoprotein and ...
 61-76 1.99e-03

ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and Cell division ATP-binding protein FtsE; This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of lipoproteins from the cytoplasmic membrane (LolCDE). They are clustered together phylogenetically. MacAB is an exporter that confers resistance to macrolides, while the LolCDE system is not a transporter at all. The FtsEX complex resembles an ABC transporter, where FtsE is the ATPase and the membrane subunit FtsX resembles a permease subunit. But rather than transporting any substrate, the complex acts in cell division by undergoing conformational changes that alter the activity of cell wall hydrolases located outside the plasma membrane. The complex is widely conserved in bacteria, but also extremely divergent in sequence between different lineages. The LolCDE complex catalyzes the release of lipoproteins from the cytoplasmic membrane prior to their targeting to the outer membrane.


Pssm-ID: 213222 [Multi-domain]  Cd Length: 218  Bit Score: 39.01  E-value: 1.99e-03
                         10
                 ....*....|....*.
gi 568913744  61 VLIVGPRGSGKTTLLN 76
Cdd:cd03255   33 VAIVGPSGSGKSTLLN 48
COG3899 COG3899
Predicted ATPase [General function prediction only];
10-82 3.16e-03

Predicted ATPase [General function prediction only];


Pssm-ID: 443106 [Multi-domain]  Cd Length: 1244  Bit Score: 39.84  E-value: 3.16e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568913744   10 AHAECLSQVQRILRERFCHHSPHSNLFGVQVQYKHLIELLKRtAIYGESNSVLIVGPRGSGKTTLLNHALKEL 82
Cdd:COG3899   264 LLLLGLLAAAAAGRRLLARRLIPQPLVGREAELAALLAALER-ARAGRGELVLVSGEAGIGKSRLVRELARRA 335
cobW pfam02492
CobW/HypB/UreG, nucleotide-binding domain; This domain is found in HypB, a hydrogenase ...
 61-84 3.18e-03

CobW/HypB/UreG, nucleotide-binding domain; This domain is found in HypB, a hydrogenase expression / formation protein, and UreG a urease accessory protein. Both these proteins contain a P-loop nucleotide binding motif. HypB has GTPase activity and is a guanine nucleotide binding protein. It is not known whether UreG binds GTP or some other nucleotide. Both enzymes are involved in nickel binding. HypB can store nickel and is required for nickel dependent hydrogenase expression. UreG is required for functional incorporation of the urease nickel metallocenter. GTP hydrolysis may required by these proteins for nickel incorporation into other nickel proteins. This family of domains also contains P47K, a Pseudomonas chlororaphis protein needed for nitrile hydratase expression, and the cobW gene product, which may be involved in cobalamin biosynthesis in Pseudomonas denitrificans.


Pssm-ID: 396860  Cd Length: 179  Bit Score: 38.00  E-value: 3.18e-03
                          10        20
                  ....*....|....*....|....
gi 568913744   61 VLIVGPRGSGKTTLLNHALKELME 84
Cdd:pfam02492   3 TVITGFLGSGKTTLLNHLLKQNRA 26
DAP3 pfam10236
Mitochondrial ribosomal death-associated protein 3; This is a family of conserved proteins ...
 45-79 3.63e-03

Mitochondrial ribosomal death-associated protein 3; This is a family of conserved proteins which were originally described as death-associated-protein-3 (DAP-3). The proteins carry a P-loop DNA-binding motif, and induce apoptosis. DAP3 has been shown to be a pro-apoptotic factor in the mitochondrial matrix and to be crucial for mitochondrial biogenesis and so has also been designated as MRP-S29 (mitochondrial ribosomal protein subunit 29).


Pssm-ID: 431160  Cd Length: 310  Bit Score: 38.82  E-value: 3.63e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 568913744   45 LIELLKRTAIYGESNSVLIVGPRGSGKTTLLNHAL 79
Cdd:pfam10236  10 LIKKLKAADKSKKVVRFVLTGEPGSGKSVLLLQAM 44
VirB11 COG0630
Type IV secretory pathway ATPase VirB11/Archaellum biosynthesis ATPase ArlI/FlaI [Cell ...
 60-76 4.86e-03

Type IV secretory pathway ATPase VirB11/Archaellum biosynthesis ATPase ArlI/FlaI [Cell motility, Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440395 [Multi-domain]  Cd Length: 462  Bit Score: 38.91  E-value: 4.86e-03
                         10
                 ....*....|....*..
gi 568913744  60 SVLIVGPRGSGKTTLLN 76
Cdd:COG0630  292 SVLVAGGTASGKTTLLN 308
ABCC_MRP_domain1 cd03250
ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C; This ...
 61-95 5.17e-03

ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C; This subfamily is also known as MRP (multidrug resistance-associated protein). Some of the MRP members have five additional transmembrane segments in their N-terminus, but the function of these additional membrane-spanning domains is not clear. The MRP was found in the multidrug-resisting lung cancer cell in which p-glycoprotein was not overexpressed. MRP exports glutathione by drug stimulation, as well as, certain substrates in conjugated forms with anions, such as glutathione, glucuronate, and sulfate.


Pssm-ID: 213217 [Multi-domain]  Cd Length: 204  Bit Score: 37.83  E-value: 5.17e-03
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 568913744  61 VLIVGPRGSGKTTLLNhALkeLMEIEVSENVIQVH 95
Cdd:cd03250   34 VAIVGPVGSGKSSLLS-AL--LGELEKLSGSVSVP 65
ATPase_2 pfam01637
ATPase domain predominantly from Archaea; This family contain a conserved P-loop motif that is ...
 61-205 5.45e-03

ATPase domain predominantly from Archaea; This family contain a conserved P-loop motif that is involved in binding ATP. There are eukaryote members as well as archaeal members in this family.


Pssm-ID: 376582 [Multi-domain]  Cd Length: 222  Bit Score: 38.07  E-value: 5.45e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568913744   61 VLIVGPRGSGKTTLLNHALKELMEIevseNVIQVHLNGLlqtnEKIALKEITRQLNLDNVVE---DKVFGSFAE------ 131
Cdd:pfam01637  23 YVIYGPEGCGKTALLRESIENLLDL----GYYVIYYDPL----RRYFISKLDRFEEVRRLAEalgIAVPKAELEesklaf 94

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568913744  132 -NLSFLLEAL-QKGDRtsscPVIFILDEFDIFAHQKNQTL---LYNLFDISQSAQTPVAVIgltcrlCLSEDSTVLEVL 205
Cdd:pfam01637  95 lAIELLLEALkRRGKK----IAIIIDEVQQAIGLNGAELLvkeLLNLIEYLTKEYHLCHVI------CLSSEGLFIELV 163
AAA_35 pfam14516
AAA-like domain; This family of proteins are part of the AAA superfamily.
 63-163 6.60e-03

AAA-like domain; This family of proteins are part of the AAA superfamily.


Pssm-ID: 373105  Cd Length: 331  Bit Score: 38.27  E-value: 6.60e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568913744   63 IVGPRGSGKTTLLNHALKELmeieVSENVIQVHLNglLQTNEKIALK-----------EITRQLNLDNVVE---DKVFGS 128
Cdd:pfam14516  36 IKAPRQMGKTSLLLRILAYA----QQQGYRTVYLD--FQLADKAILTdldkflrwfcaNISRQLGLPPKLDdywDEDLGS 109

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 568913744  129 faeNLS-------FLLEALQKgdrtsscPVIFILDEFD-IFAH 163
Cdd:pfam14516 110 ---KVSctiyfedYLLPQIDR-------PLVLALDEVDrLFEY 142
CpaF COG4962
Pilus assembly protein, ATPase of CpaF family [Intracellular trafficking, secretion, and ...
 60-92 6.86e-03

Pilus assembly protein, ATPase of CpaF family [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 443988 [Multi-domain]  Cd Length: 386  Bit Score: 38.22  E-value: 6.86e-03
                         10        20        30
                 ....*....|....*....|....*....|...
gi 568913744  60 SVLIVGPRGSGKTTLLNhALkeLMEIEVSENVI 92
Cdd:COG4962  184 NILVSGGTGSGKTTLLN-AL--SGFIPPDERIV 213
ABC_tran pfam00005
ABC transporter; ABC transporters for a large family of proteins responsible for translocation ...
 61-177 7.68e-03

ABC transporter; ABC transporters for a large family of proteins responsible for translocation of a variety of compounds across biological membranes. ABC transporters are the largest family of proteins in many completely sequenced bacteria. ABC transporters are composed of two copies of this domain and two copies of a transmembrane domain pfam00664. These four domains may belong to a single polypeptide or belong in different polypeptide chains.


Pssm-ID: 394964 [Multi-domain]  Cd Length: 150  Bit Score: 36.47  E-value: 7.68e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568913744   61 VLIVGPRGSGKTTLLNHALKELMEIEVSenvIQVHLNGLLQTNEKIALKEI---TRQLNLDNvvedkvFGSFAENLSFLL 137
Cdd:pfam00005  14 LALVGPNGAGKSTLLKLIAGLLSPTEGT---ILLDGQDLTDDERKSLRKEIgyvFQDPQLFP------RLTVRENLRLGL 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 568913744  138 EALQKGDRTSSCPVIFILDEFDIFaHQKNQTLLYNLFDIS 177
Cdd:pfam00005  85 LLKGLSKREKDARAEEALEKLGLG-DLADRPVGERPGTLS 123
YbbA COG4181
Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase ...
 56-75 8.38e-03

Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 443338 [Multi-domain]  Cd Length: 233  Bit Score: 37.41  E-value: 8.38e-03
                         10        20
                 ....*....|....*....|
gi 568913744  56 GESnsVLIVGPRGSGKTTLL 75
Cdd:COG4181   38 GES--VAIVGASGSGKSTLL 55
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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