BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 43 (ZBTB43); ZBTB43, also called zinc finger and BTB domain-containing protein 22B (ZBTB22b), zinc finger protein 297B (ZNF297B), or ZnF-x, may be involved in transcriptional regulation. It interacts with BDP1, a subunit of transcription factor IIIB (TFIIIB). Since BDP1 is essential in Pol III transcription, ZBTB43 may also regulate these transcriptional pathways. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914334   8 FQVEFPDFSSTILQKLNQQRQQGQLCDVSIVVQGHIFQAHKAVLAASSPYFCDQVLLKNSRRIVLPDVMNPRVFENILLF 87
Cdd:cd18227    1 FRVEFPDFSSTILQKLNQQRQQGQLCDISVVVQGHLFRAHKAVLAASSPYFCDQVLLKNSRRIVLPDVMNPRVFENILLS 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 568914334  88 SYTGRLVMPAPEIVSYLTAASFLQMWHVVDKCTEVLEGNPT 128
Cdd:cd18227   81 CYTGRLVLPAPEIVSYLTAASFLQMWHVVDKCTELLEGNPT 121

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 43 (ZBTB43); ZBTB43, also called zinc finger and BTB domain-containing protein 22B (ZBTB22b), zinc finger protein 297B (ZNF297B), or ZnF-x, may be involved in transcriptional regulation. It interacts with BDP1, a subunit of transcription factor IIIB (TFIIIB). Since BDP1 is essential in Pol III transcription, ZBTB43 may also regulate these transcriptional pathways. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914334   8 FQVEFPDFSSTILQKLNQQRQQGQLCDVSIVVQGHIFQAHKAVLAASSPYFCDQVLLKNSRRIVLPDVMNPRVFENILLF 87
Cdd:cd18227    1 FRVEFPDFSSTILQKLNQQRQQGQLCDISVVVQGHLFRAHKAVLAASSPYFCDQVLLKNSRRIVLPDVMNPRVFENILLS 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 568914334  88 SYTGRLVMPAPEIVSYLTAASFLQMWHVVDKCTEVLEGNPT 128
Cdd:cd18227   81 CYTGRLVLPAPEIVSYLTAASFLQMWHVVDKCTELLEGNPT 121

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914334    34 DVSIVVQGHIFQAHKAVLAASSPYF----CDQVLLKNSRRIVLPDVmNPRVFENILLFSYTGRLVMPAPEIVSYLTAASF 109
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFkalfSSDFKESDKSEIYLDDV-SPEDFRALLNFLYTGKLDLPEENVEELLELADY 79

                           90
                   ....*....|....*..
gi 568914334   110 LQMWHVVDKCTEVLEGN 126
Cdd:smart00225  80 LQIPGLVELCEEFLLKL 96

Zinc-finger double domain;

                          10        20
                  ....*....|....*....|....
gi 568914334  414 HLVGHMKIHTGIKPYECNICAKRF 437
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 43 (ZBTB43); ZBTB43, also called zinc finger and BTB domain-containing protein 22B (ZBTB22b), zinc finger protein 297B (ZNF297B), or ZnF-x, may be involved in transcriptional regulation. It interacts with BDP1, a subunit of transcription factor IIIB (TFIIIB). Since BDP1 is essential in Pol III transcription, ZBTB43 may also regulate these transcriptional pathways. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914334   8 FQVEFPDFSSTILQKLNQQRQQGQLCDVSIVVQGHIFQAHKAVLAASSPYFCDQVLLKNSRRIVLPDVMNPRVFENILLF 87
Cdd:cd18227    1 FRVEFPDFSSTILQKLNQQRQQGQLCDISVVVQGHLFRAHKAVLAASSPYFCDQVLLKNSRRIVLPDVMNPRVFENILLS 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 568914334  88 SYTGRLVMPAPEIVSYLTAASFLQMWHVVDKCTEVLEGNPT 128
Cdd:cd18227   81 CYTGRLVLPAPEIVSYLTAASFLQMWHVVDKCTELLEGNPT 121

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37); ZBTB37 may be involved in transcriptional regulation. It is differentially expressed in aryl hydrocarbon receptor (AhR)-KO mice compared with WT mice, and may potentially contribute to the aging phenotype of AhR-KO mice. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914334   9 QVEFPDFSSTILQKLNQQRQQGQLCDVSIVVQGHIFQAHKAVLAASSPYFCDQVLLKNSRRIVLPDVMNPRVFENILLFS 88
Cdd:cd18222    2 QLEIPDFSNSVLSHLNQLRMQGRLCDIVVNVQGQSFRAHKVVLAASSPYFRDHMSLNEMSTVSISVIKNPTVFEQLLSFC 81

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 568914334  89 YTGRLVMPAPEIVSYLTAASFLQMWHVVDKCTEVLEG 125
Cdd:cd18222   82 YTGRICLQLADIISYLTAASFLQMQHIIDKCTQILEG 118

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 34 (ZBTB34); ZBTB34 acts as a transcriptional regulator. It downregulates specificity protein (Sp) transcription factors Sp1, Sp3, and Sp4 in pancreatic cancer cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914334   9 QVEFPDFSSTILQKLNQQRQQGQLCDVSIVVQGHIFQAHKAVLAASSPYFCDQVLLKNSRRIVLPDVMNPRVFENILLFS 88
Cdd:cd18220    2 QFDVPEYSNTVLSQLNELRLQGKLCDIIVHIQGQPFRAHKAVLAASSPYFRDHSALSTMSGLSISVIKNPNVFEQLLSFC 81

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 568914334  89 YTGRLVMPAPEIVSYLTAASFLQMWHVVDKCTEVLEG 125
Cdd:cd18220   82 YTGRMSLQLKDVVSFLTAASFLQMQCVIDKCTQILES 118

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914334   23 LNQQRQQGQLCDVSIVVQGHIFQAHKAVLAASSPYFCDQVLLK----NSRRIVLPDVmNPRVFENILLFSYTGRLvMPAP 98
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQesesSVSEITLDDV-SPEDFEALLEFMYTGKL-ISEE 78

                          90       100
                  ....*....|....*....|....*
gi 568914334   99 EIVSYLTAASFLQMWHVVDKCTEVL 123
Cdd:pfam00651  79 NVDDLLAAADKLQIPSLVDKCEEFL 103

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 6 (ZBTB6); ZBTB6, also called zinc finger protein 482 (ZNF482) or zinc finger protein with interaction domain, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914334  11 EFPDFSSTILQKLNQQRQQGQLCDVSIVVQGHIFQAHKAVLAASSPYFCDQVLLKNSRRIVLPDVMNPRVFENILLFSYT 90
Cdd:cd18197    4 KFEQQGDAVLQKMNLLRQQNLFCDVSIYINDTEFHGHKVILAACSTFMRDQFLLNQSKQVRITILQSAEVGRKLLLSCYT 83

                         90       100       110
                 ....*....|....*....|....*....|...
gi 568914334  91 GRLVMPAPEIVSYLTAASFLQMWHVVDKCTEVL 123
Cdd:cd18197   84 GALEVKKKELLKYLTAASYLQMVHIVEKCTEAL 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 12 (ZBTB12); ZBTB12, also called protein G10, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914334   7 SFQVefPDFSSTILQKLNQQRQQGQLCDVSIVVQGHIFQAHKAVLAASSPYFCDQVLLKNSRRIVLPDVMNPRVFENILL 86
Cdd:cd18203    2 RFQL--PGHEAATLRNMNQLRSEERFCDVTIVADSLKFRGHKVVLAACSPFLRDQFLLNPSSELQVSLMHSSRVVADLLL 79

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 568914334  87 FSYTGRLVMPAPEIVSYLTAASFLQMWHVVDKCTEVL 123
Cdd:cd18203   80 SCYTGALEFSVRDIVNYLTAASYLQMEHVVEKCRGAL 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 45 (ZBTB45); ZBTB45, also called zinc finger protein 499 (ZNF499), may act as a transcriptional regulator that is essential for proper glial differentiation of neural and oligodendrocyte progenitor cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914334  15 FSSTILQKLNQQRQQGQLCDVSIVVQGHIFQAHKAVLAASSPYFCDQVLLKNSrRIVLPDVMNPRVFENILLFSYTGRLV 94
Cdd:cd18229    1 FSKSLLETLNAQRLGGHFCDVTVRIHDASLRAHRCVLAAGSPFFHDKLLLGHS-EIEVPPVVPAQTVRQLVEFMYSGSLV 79

                         90       100       110
                 ....*....|....*....|....*....|..
gi 568914334  95 MPAPEIVSYLTAASFLQMWHVVDKCTEVLEGN 126
Cdd:cd18229   80 VAQSEALQILTAASILQIKTVIDECTQIISQS 111

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914334  32 LCDVSIVVQGHIFQAHKAVLAASSPYFCDQVLL----KNSRRIVLPDVmNPRVFENILLFSYTGRLVMPAPEIVSYLTAA 107
Cdd:cd18186    1 LCDVTLVVGGREFPAHRAVLAARSPYFRAMFSSgmkeSSSSEIELDDV-SPEAFEALLDYIYTGELELSEENVEELLAAA 79

                 ...
gi 568914334 108 SFL 110
Cdd:cd18186   80 DKL 82

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 2 protein (Hic-2); Hic-2 is also called HIC1-related gene on chromosome 22 protein (HRG22), Hic-3, or zinc finger and BTB domain-containing protein 30 (ZBTB30). It is a homolog of tumor suppressor Hic-1. It functions as a transcriptional regulator. It is a dosage-dependent regulator of cardiac development located within the distal 22q11 deletion syndrome region. Hic-2 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914334  12 FPDFSSTILQKLNQQRQQGQLCDVSIVVQGHIFQAHKAVLAASSPYFCDQVLLKNsrRIVL-PDVMNPRVFENILLFSYT 90
Cdd:cd18334    1 LPNHAKQLLLQLNQQRAKGFLCDVIIVVENALFRAHKNILAASSMYFKSLVLHDN--LINLdTDMVNPTVFRQILDFIYT 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 568914334  91 GRLV---MPA-PEIVSYLTAASFLQMWHVVDKCTEVLEGN 126
Cdd:cd18334   79 GKLLtsdQPGeQNFNALLTAASYLQLHDLAALCRKKLKRN 118

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for a Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914334  14 DFSSTILQKLNQQRQQGQLCDVSIVVQGHIFQAHKAVLAASSPY----FCDQVLLKNSRRIVLPDvMNPRVFENILLFSY 89
Cdd:cd18247    1 DLPSSGFPVMEEIRRQGKLCDVTLKVGDQKFSAHRIVLAATIPYfhamFTHDMVESKQDEITMQG-IEPSALEALINFAY 79

                         90       100       110
                 ....*....|....*....|....*....|....
gi 568914334  90 TGRLVMPAPEIVSYLTAASFLQMWHVVDKCTEVL 123
Cdd:cd18247   80 SGRIAIDTSNVQSLLVGASFLQLQSVKDACCEFL 113

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 20 (ZBTB20); ZBTB20, also called dendritic-derived BTB/POZ zinc finger protein (DPZF) or zinc finger protein 288, may be a transcription factor involved in hematopoiesis, oncogenesis, and immune responses. It is an essential regulator of hepatic lipogenesis and may be a therapeutic target for the treatment of fatty liver disease. It also functions as a critical regulator of anterior pituitary development and lactotrope specification. Moreover, it promotes astrocytogenesis during neocortical development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914334   9 QVEFPDFSSTILQKLNQQRQQGQLCDVSIVVQGHIFQAHKAVLAASSPYFCDQVLLKNSrRIVLPDVMNPRVFENILLFS 88
Cdd:cd18208    2 SINLHNFSNSVLETLNEQRNRGHFCDVTVRIHGSMLRAHRCVLAAGSPFFQDKLLLGYS-DIEIPSVVSVQSVQKLIDFM 80

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 568914334  89 YTGRLVMPAPEIVSYLTAASFLQMWHVVDKCTEVL 123
Cdd:cd18208   81 YSGVLRVSQSEALQILTAASILQIKTVIDECTRIV 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 46 (ZBTB46); ZBTB46 is also called BTB-ZF protein expressed in effector lymphocytes (BZEL), BTB/POZ domain-containing protein 4 (BTBD4), or zinc finger protein 340 (ZNF340). It is a conventional dendritic cell (cDC) lineage specific transcription factor that acts as a negative regulator required to prevent activation of classical dendritic cells in the steady state. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914334  19 ILQKLNQQRQQGQLCDVSIVVQGHIFQAHKAVLAASSPYF----CDQVLLKNSRRIVLPDVMNPRVFENILLFSYTGRLV 94
Cdd:cd18230    8 LLRELNEQRQHGILCDVCIIVEGKIFKAHKNVLLGSSRYFktlyCQVQKTSDQATVTHLDIVTAQGFKAIIDFMYSAHLA 87

                         90       100
                 ....*....|....*....|....*
gi 568914334  95 MPAPEIVSYLTAASFLQMWHVVDKC 119
Cdd:cd18230   88 LTSKNVIEVMSAASYLQMTDIVQAC 112

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914334  17 STILQKLNQQRQQGQLCDVSIVVQGHIFQAHKAVLAASSPYFcdQVLL-----KNSRRIVLPDVMNPRVFENILLFSYTG 91
Cdd:cd18256    5 SLILAQLNKLRGQHEFCDVQLQVGMELFSVHRLVLAASSPYF--AALFaggmsESSKDVVQIHGVEPDIFHILLDFIYTG 82

                         90       100       110
                 ....*....|....*....|....*....|....
gi 568914334  92 RLVMPAPEIVSYLTAASFLQMWHVVDKCTEVLEG 125
Cdd:cd18256   83 VVEVTVSNVQELLVAADMLQLTEVVEICCEFLKG 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8 (ZBTB8); There are two ZBTB8 isoforms: ZBTB8A and ZBTB8B. ZBTB8A is a novel proto-oncoprotein that stimulates cell proliferation. ZBTB8B may be involved in transcriptional regulation. They both contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914334  17 STILQKLNQQRQQGQLCDVSIVVQGHIFQAHKAVLAASSPYFcDQVLLKNSRRIVLP-----DVMNPRVFENILLFSYTG 91
Cdd:cd18199    3 SRLLGQLNEQRKQDFFCDCSIIVEGRIFKAHRNVLFASSGYF-RMLLSHYIQDTGRPstasfDVFSSDAFSIILDFVYSG 81

                         90       100
                 ....*....|....*....|....*...
gi 568914334  92 RLVMPAPEIVSYLTAASFLQMWHVVDKC 119
Cdd:cd18199   82 KLSLTSQNVIEVMSAASYLQMTDVINVC 109

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18, ZBTB42 and similar proteins; The family includes zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18 and ZBTB42. ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB18 is a sequence-specific transrepressor associated with heterochromatin. ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914334  10 VEFPDFSSTILQKLNQQRQQGQLCDVSIVVQGHIFQAHKAVLAASSPYFcdQVLLK---NSRRIVL--PDVMNPRVFENI 84
Cdd:cd18194    1 MEFPEHSRQLLQCLREQRSQGFLCDCTVLVGSAQFPAHRAVLASCSMYF--HLFYRdrlDKRDLVRlnSDIVTAPAFGLL 78

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 568914334  85 LLFSYTGRLVMPAPEIVSYLTAASFLQMWHVVDKC 119
Cdd:cd18194   79 LDFMYEGRLALRDLPVEDVLAAASYLHMYDIVKVC 113

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 2 (BACH2); BACH2, also called BTB-basic leucine zipper transcription factor 2, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). It is also a potent general repressor of effector differentiation in naive T cells. Moreover, BACH2 is required for pulmonary surfactant homeostasis and alveolar macrophage function. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914334  17 STILQKLNQQRQQGQLCDVSIVVQGHIFQAHKAVLAASSPYFCdQVLL---KNSRRIVLPDVMNPRVFENILLFSYTGRL 93
Cdd:cd18278   16 TNILLCLNDQRKQDILCDVTLIVEGKEFRAHRAVLAACSEYFL-QALVgqtENDLVVSLPEEVTARGFGPLLQFAYTAKL 94

                         90       100       110
                 ....*....|....*....|....*....|
gi 568914334  94 VMPAPEIVSYLTAASFLQMWHVVDKCTEVL 123
Cdd:cd18278   95 LLSRENIQEVIRCAEFLRMHNLEDSCFRFL 124

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 38 (ZBTB38); ZBTB38, also termed CIBZ, is a transcriptional regulator with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3', as well as E-box elements (5'-CACGTG-3'). It can also bind specifically to a single methyl-CpG pair. ZBTB38 represses transcription in a methyl-CpG-dependent manner. It is a negative regulator of endoplasmic reticulum stress-associated apoptosis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914334  16 SSTILQKLNQQRQQGQLCDVSIVVQGHIFQAHKAVLAASSPYF----CDQVLLKNSRRIVLPDvMNPRVFENILLFSYTG 91
Cdd:cd18223    2 SDTVLSCLNEQRIQGILCDVTIVVEDTKFKAHKNVLAASSLYFknafSSQEIWISSHVLELPD-LKAEVFAEILNFIYSS 80

                         90       100
                 ....*....|....*....|....*.
gi 568914334  92 RLVMPAPEIVSYLTAA------SFLQ 111
Cdd:cd18223   81 KVVVKRQETVTDLVAAgkklgiTFLE 106

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A); ZBTB7A is also called factor binding IST protein 1 (FBI-1), factor that binds to inducer of short transcripts protein 1, HIV-1 1st-binding protein 1, Leukemia/lymphoma-related factor (LRF), POZ and Krueppel erythroid myeloid ontogenic factor, POK erythroid myeloid ontogenic factor, Pokemon, TTF-I-interacting peptide 21 (TIP21), or zinc finger protein 857A (ZNF857A). It is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. It has been implicated in carcinogenesis and cell differentiation and development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914334  10 VEFPDFSSTILQKLNQQRQQGQLCDVSIVVQGHIFQAHKAVLAASSPYF---CDQVLLKNSRRIVLPDVMNPRVFENILL 86
Cdd:cd18326    3 IPFPDHSSDILSSLNEQRTQGLLCDVVILVEGREFPTHRSVLAACSQYFkklFTSGAVVDQQNVYEIDFVSAEALTALLD 82

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 568914334  87 FSYTGRLVMPAPEIVSYLTAASFLQMWHVVDKCTEVLE 124
Cdd:cd18326   83 FAYTATLTVSTSNVGDILSAARLLEIPAVSHVCADLLD 120

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7C (ZBTB7C); ZBTB7C is also called affected by papillomavirus DNA integration in ME180 cells protein 1 (APM-1), zinc finger and BTB domain-containing protein 36 (ZBTB36), zinc finger protein 857C (ZNF857C), or kidney cancer-related POZ domain and Kruppel-like protein (Kr-POK). It is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. It may act as an important regulator of fatty acid synthesis and may induce rapid cancer cell proliferation by increasing palmitate synthesis. The ZBTB7C gene has been identified as a susceptibility gene to ischemic injury. ZBTB7C contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914334  10 VEFPDFSSTILQKLNQQRQQGQLCDVSIVVQGHIFQAHKAVLAASSPYF---------CDQvllknsRRIVLPDVMNPRV 80
Cdd:cd18328    3 IPFPNHSSEVLCSLNEQRHDGLLCDVVLIVQDQEYRTHRSVLAACSKYFkklftagtlADQ------PYVYEIDFVTPEA 76

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 568914334  81 FENILLFSYTGRLVMPAPEIVSYLTAASFLQMWHVVDKCTEVLE 124
Cdd:cd18328   77 LSAILEFAYTSTLTITTSNVKHILNAAQMLEIQCIINVCLEIMD 120

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in myoneurin; Myoneurin, also called zinc finger and BTB domain-containing protein 31 (ZBTB31), is a novel member of the BTB/POZ-zinc finger family highly expressed in the neuromuscular system and is associated with neuromuscular junctions during the late embryonic period. It may function as a synaptic gene regulator. Myoneurin contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914334  19 ILQKLNQQRQQGQLCDVSIVVQGHIFQAHKAVLAASSPYFCDQVLLKNSRRIVL-PDVMNPRVFENILLFSYTGRLVMPA 97
Cdd:cd18217    5 LLERLNKQREAGFLCDCTIVIGQFQFKAHRNVLAAFSEYFGAQYKDTEDNIVFLdQSQVSADGFQKLLEFIYTGNLNLDS 84

                         90       100
                 ....*....|....*....|....*..
gi 568914334  98 PEIVSYLTAASFLQMWHVVDKCTEVLE 124
Cdd:cd18217   85 WNVAEIHQAASYLGMEEVVAKCKIKME 111

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 10 (KLHL10); KLHL10 is a substrate-specific adaptor of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins specifically in the testis during spermatogenesis. Haploinsufficiency of Klhl10 causes infertility in male mice. KLHL10 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914334  16 SSTILQKLNQQRQQGQLCDVSIVVQGHIFQAHKAVLAASSPYFcdQVLLKNS------RRIVLPDVmNPRVFENILLFSY 89
Cdd:cd18240    1 SAMACNVFNELRLEGKLCDVVIRVNGVEFPAHRNILCACSPYF--RALFTNGwnetekKVYKIPGV-SPEMMELIIEYAY 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 568914334  90 TGRLVMPAPEIVSYLTAASFLQMWHVVDKCTEVLEGNPTV 129
Cdd:cd18240   78 TRTVPITAENVEELLPAADQFNIMGIVKACCDFLEDQLCP 117

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell CLL/lymphoma 6 member B protein (BCL6B); BCL6B is also called Bcl6-associated zinc finger protein, zinc finger protein 62, or zinc finger and BTB domain-containing protein 28 (ZBTB28). It is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. BCL6B plays an important role as a potential tumor suppressor in gastric cancer; it is found preferentially methylated in gastric cancer. It also inhibits both colorectal cancer growth and hepatocellular carcinoma metastases. BCL6B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914334  16 SSTILQKLNQQRQQGQLCDVSIVVQGHIFQAHKAVLAASSPYFCdQVLLKNSRRIV----LPDVMNPRVFENILLFSYTG 91
Cdd:cd18332    3 SSDVLLNLNELRKRDILTDVTLLVGGTPLRAHKAVLIACSGFFY-SIFSGRVGEGVsvltLPSGLEARGFQLLLDFMYTS 81

                         90       100
                 ....*....|....*....|....*...
gi 568914334  92 RLVMPAPEIVSYLTAASFLQMWHVVDKC 119
Cdd:cd18332   82 RLPLTPRTVPAVLAAATYLQMEHVVETC 109

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in POZ-, AT hook-, and zinc finger-containing protein 1 (PATZ1); PATZ1 is also called zinc finger and BTB domain-containing protein 19 (ZBTB19), BTB/POZ domain zinc finger transcription factor, protein kinase A RI subunit alpha-associated protein, zinc finger protein 278, or zinc finger sarcoma gene protein. It is an important transcriptional regulatory factor that regulates divergent pathways depending on the cellular context. For instance, it acts as a transcriptional suppressor that functions in T lymphocytes. It is also a DNA damage-responsive transcription factor that inhibits p53 function. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914334   7 SFQVEFPDFSSTILQKLNQQRQQG-QLCDVSIVVQGHIFQAHKAVLAASSPYF----CDQVLLKNSRRIVLPDVMNPRVF 81
Cdd:cd18207    1 SYTYQVSQHSADMLHNLNQQRKSGgRFCDVLLRVGEESFPAHRAVLAACSEYFesvfSAQEGDGGTPRELEMHTISSKVF 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 568914334  82 ENILLFSYTGRLVMPAPEIVSYLTAASFLQMWHVVDKCTEVLE 124
Cdd:cd18207   81 GDILDFAYTSRIVVRLESFPELMTAAKFLLMRSVIDICQEVIK 123

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914334  32 LCDVSIVVQGHIFQAHKAVLAASSPYFCDqvLLKNSR-----RIVLPDVmNPRVFENILLFSYTGRLVMPAPEIVSYLTA 106
Cdd:cd18315    1 LVDVTLACEGGSLKAHKLVLAAASPYFAA--LLKETPpdehpVIILPDV-PYSELKALLDFIYTGEVNVSQEQLESLLKL 77

                 ....*
gi 568914334 107 ASFLQ 111
Cdd:cd18315   78 AELLQ 82