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Conserved domains on  [gi|568929272|ref|XP_006503236|]
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selection and upkeep of intraepithelial T-cells protein 7 isoform X3 [Mus musculus]

Protein Classification

Ig_MOG_like domain-containing protein( domain architecture ID 10145916)

Ig_MOG_like domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IgV_MOG_like cd05713
Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG); The members here ...
 29-141 1.79e-58

Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG); The members here are composed of the immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG). MOG, a minor component of the myelin sheath, is an important CNS-specific autoantigen, linked to the pathogenesis of multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE). It is a transmembrane protein having an extracellular Ig domain. MOG is expressed in the CNS on the outermost lamellae of the myelin sheath, and on the surface of oligodendrocytes, and may participate in the completion, compaction, and/or maintenance of myelin. This group also includes butyrophilin (BTN). BTN is the most abundant protein in bovine milk-fat globule membrane (MFGM).


:

Pssm-ID: 409378  Cd Length: 114  Bit Score: 180.85  E-value: 1.79e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929272  29 RVTTPTRHLLARVGGQAELSCQVIPPHSVMHMEVRWFRSGHSQPVYLYRGGHKMSEEAAPEYANRTEFVKEAIGEGKVSL 108
Cdd:cd05713    2 SVIGPTEPILALVGEDAELPCHLSPKMSAEHMEVRWFRSQFSPVVHLYRDGQDQEEEQMPEYRGRTELLKDAIAEGSVAL 81

                         90       100       110
                 ....*....|....*....|....*....|...
gi 568929272 109 RIHNINILDDGPYQCSFNGSGFIDAAIMNLNVT 141
Cdd:cd05713   82 RIHNVRPSDEGQYTCFFRSGSFYEEATLELKVA 114
 
Name Accession Description Interval E-value
IgV_MOG_like cd05713
Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG); The members here ...
 29-141 1.79e-58

Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG); The members here are composed of the immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG). MOG, a minor component of the myelin sheath, is an important CNS-specific autoantigen, linked to the pathogenesis of multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE). It is a transmembrane protein having an extracellular Ig domain. MOG is expressed in the CNS on the outermost lamellae of the myelin sheath, and on the surface of oligodendrocytes, and may participate in the completion, compaction, and/or maintenance of myelin. This group also includes butyrophilin (BTN). BTN is the most abundant protein in bovine milk-fat globule membrane (MFGM).


Pssm-ID: 409378  Cd Length: 114  Bit Score: 180.85  E-value: 1.79e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929272  29 RVTTPTRHLLARVGGQAELSCQVIPPHSVMHMEVRWFRSGHSQPVYLYRGGHKMSEEAAPEYANRTEFVKEAIGEGKVSL 108
Cdd:cd05713    2 SVIGPTEPILALVGEDAELPCHLSPKMSAEHMEVRWFRSQFSPVVHLYRDGQDQEEEQMPEYRGRTELLKDAIAEGSVAL 81

                         90       100       110
                 ....*....|....*....|....*....|...
gi 568929272 109 RIHNINILDDGPYQCSFNGSGFIDAAIMNLNVT 141
Cdd:cd05713   82 RIHNVRPSDEGQYTCFFRSGSFYEEATLELKVA 114
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 37-141 8.83e-07

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 46.30  E-value: 8.83e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929272   37 LLARVGGQAELSCQVIPPHSVMHMEVRWFR----SGHSQPVYLYRGGHKMseeaaPEYANRTEFvKEAIGEGKVSLRIHN 112
Cdd:pfam07686   6 VTVALGGSVTLPCTYSSSMSEASTSVYWYRqppgKGPTFLIAYYSNGSEE-----GVKKGRFSG-RGDPSNGDGSLTIQN 79

                          90       100       110
                  ....*....|....*....|....*....|
gi 568929272  113 INILDDGPYQCSFNGSG-FIDAAIMNLNVT 141
Cdd:pfam07686  80 LTLSDSGTYTCAVIPSGeGVFGKGTRLTVL 109
IGv smart00406
Immunoglobulin V-Type;
45-125 1.93e-06

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 44.68  E-value: 1.93e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929272    45 AELSCQViPPHSVMHMEVRWFRSGHSQPVY-LYRGGHKMSEEAAPEYANRTEFVKEAiGEGKVSLRIHNINILDDGPYQC 123
Cdd:smart00406   2 VTLSCKF-SGSTFSSYYVSWVRQPPGKGLEwLGYIGSNGSSYYQESYKGRFTISKDT-SKNDVSLTISNLRVEDTGTYYC 79


                   ..
gi 568929272   124 SF 125
Cdd:smart00406  80 AV 81
 
Name Accession Description Interval E-value
IgV_MOG_like cd05713
Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG); The members here ...
 29-141 1.79e-58

Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG); The members here are composed of the immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG). MOG, a minor component of the myelin sheath, is an important CNS-specific autoantigen, linked to the pathogenesis of multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE). It is a transmembrane protein having an extracellular Ig domain. MOG is expressed in the CNS on the outermost lamellae of the myelin sheath, and on the surface of oligodendrocytes, and may participate in the completion, compaction, and/or maintenance of myelin. This group also includes butyrophilin (BTN). BTN is the most abundant protein in bovine milk-fat globule membrane (MFGM).


Pssm-ID: 409378  Cd Length: 114  Bit Score: 180.85  E-value: 1.79e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929272  29 RVTTPTRHLLARVGGQAELSCQVIPPHSVMHMEVRWFRSGHSQPVYLYRGGHKMSEEAAPEYANRTEFVKEAIGEGKVSL 108
Cdd:cd05713    2 SVIGPTEPILALVGEDAELPCHLSPKMSAEHMEVRWFRSQFSPVVHLYRDGQDQEEEQMPEYRGRTELLKDAIAEGSVAL 81

                         90       100       110
                 ....*....|....*....|....*....|...
gi 568929272 109 RIHNINILDDGPYQCSFNGSGFIDAAIMNLNVT 141
Cdd:cd05713   82 RIHNVRPSDEGQYTCFFRSGSFYEEATLELKVA 114
IgV_B7-H4 cd20984
Immunoglobulin Variable (IgV) domain of B7-H4; The members here are composed of the ...
 31-123 4.01e-11

Immunoglobulin Variable (IgV) domain of B7-H4; The members here are composed of the immunoglobulin variable (IgV) domain of B7-H4 (also known as B7-S1, B7x, or Vtcn1). B7-H4 is one of the B7 family of immune-regulatory ligands that act as negative regulators of T cell function; it contains one IgV domain and one IgC domain. The B7-family consists of structurally related cell-surface protein ligands, which bind to receptors on lymphocytes that regulate immune responses. The binding of B7-H4 to unidentified receptors results in the inhibition of TCR-mediated T cell proliferation, cell-cycle progression and IL-2 production. As a co-inhibitory molecule, B7-H4 is widely expressed in tumor tissues and its expression is significantly associated with poor prognosis in human cancers such as glioma, pancreatic cancer, oral squamous cell carcinoma, renal cell carcinoma, and lung cancer.


Pssm-ID: 409576  Cd Length: 110  Bit Score: 58.38  E-value: 4.01e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929272  31 TTPTRHLLARVGGQAELSCQVIPPHSVMHMEVRWFRSGHSQPVYLYRGGHKMSEEAAPEYANRTEFVKEAIGEGKVSLRI 110
Cdd:cd20984    1 TVTAKHLAGNIGEDGILSCTFTPDIKLSDIVIQWLKEGDSGLVHEFKEGKDELSRQSPMFRGRTSLFADQVHVGNASLRL 80

                         90
                 ....*....|...
gi 568929272 111 HNINILDDGPYQC 123
Cdd:cd20984   81 KNVQLTDAGTYLC 93
IgV_1_PVR_like cd05718
First immunoglobulin variable (IgV) domain of poliovirus receptor (PVR, also known as CD155 ...
 29-125 6.17e-08

First immunoglobulin variable (IgV) domain of poliovirus receptor (PVR, also known as CD155 and necl-5), and similar domains; The members here are composed of the first immunoglobulin (Ig) domain of poliovirus receptor (PVR, also known as CD155 and nectin-like protein 5 (necl-5)). Poliovirus (PV) binds to its cellular receptor (PVR/CD155) to initiate infection. CD155 is a membrane-anchored, single-span glycoprotein; its extracellular region has three Ig-like domains. There are four different isotypes of CD155 (referred to as alpha, beta, gamma, and delta), that result from alternate splicing of the CD155 mRNA, and have identical extracellular domains. CD155-beta and CD155-gamma are secreted; CD155-alpha and CD155-delta are membrane-bound and function as PV receptors. The virus recognition site is contained in the amino-terminal domain, D1. Having the virus attachment site on the receptor distal from the plasma membrane may be important for successful initiation of infection of cells by the virus. CD155 binds in the poliovirus "canyon" with a footprint similar to that of the intercellular adhesion molecule-1 receptor on human rhinoviruses. This group also includes the first Ig-like domain of nectin-1 (also known as poliovirus receptor related protein(PVRL)1; CD111), nectin-3 (also known as PVRL 3), nectin-4 (also known as PVRL4; LNIR receptor)and DNAX accessory molecule 1 (DNAM-1; CD226).


Pssm-ID: 409383  Cd Length: 113  Bit Score: 49.75  E-value: 6.17e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929272  29 RVTTPTrHLLARVGGQAELSCQVIPPHSVMHMEVRWFR--SGHSQPVYLYRGGHKMSEEAapEYANRTEFVKEAIGEGKV 106
Cdd:cd05718    2 RVQVPT-EVTGFLGGSVTLPCSLTSPGTTKITQVTWMKigAGSSQNVAVFHPQYGPSVPN--PYAERVEFLAARLGLRNA 78

                         90
                 ....*....|....*....
gi 568929272 107 SLRIHNINILDDGPYQCSF 125
Cdd:cd05718   79 TLRIRNLRVEDEGNYICEF 97
IgV_B7-H3 cd20934
Immunoglobulin Variable (IgV) domain of B7-H3, a member of the B7 family of immune checkpoint ...
 33-142 2.96e-07

Immunoglobulin Variable (IgV) domain of B7-H3, a member of the B7 family of immune checkpoint molecules; The members here are composed of the immunoglobulin variable (IgV) domain of B7-H3 also known as CD276), a member of the B7 family of immune checkpoint molecules. B7-H3 is an important immune checkpoint member of the B7 family and shares homology with other B7 ligands such as programmed death ligand 1 (PD-L1). The B7 family molecules interact with CD28 on T-cells to provide co-stimulatory signals that regulate T-cell activation and T-helper cell differentiation. Although B7-H3 has been shown to have both co-stimulatory and co-inhibitory effects on T-cell responses, the most current studies describe B7-H3 as a T cell inhibitor that promotes tumor aggressiveness and proliferation. Moreover, B7-H3 is highly overexpressed on a wide range of human solid cancers and promotes tumor growth, metastasis, and drug resistance. Thus, B7-H3 expression in tumors often correlates with both negative prognosis and poor clinical outcome in cancer patients. B7-H3 protein contains a predicted signal peptide, V- and C-like Ig domains (IgV and IgC), a transmembrane region, and an intracellular tail.


Pssm-ID: 409528  Cd Length: 115  Bit Score: 47.60  E-value: 2.96e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929272  33 PTRHLLARVGGQAELSCQVIPPH--SVMHMEVRWFRSGHSQPVYLYRGGHKMSEEAAPEYANRTEFVKEAIGEGKVSLRI 110
Cdd:cd20934    3 PEDPVVALVGTDATLRCSFSPEPgfSLAQLSVFWQLTDTKQLVHSFTESQDQGRDQGSAYANRTALFPDLLAQGNASLRL 82

                         90       100       110
                 ....*....|....*....|....*....|..
gi 568929272 111 HNINILDDGPYQCSFNGSGFIDAAImNLNVTA 142
Cdd:cd20934   83 QRVRVADEGSYTCFVSVQDFGSAAV-SLQVAA 113
IgV_HHLA2 cd16091
Immunoglobulin Variable (IgV) domain in HERV-H LTR-associating 2 (HHLA2); The members here are ...
 47-123 3.49e-07

Immunoglobulin Variable (IgV) domain in HERV-H LTR-associating 2 (HHLA2); The members here are composed of the immunoglobulin variable (IgV) region in HERV-H LTR-associating 2 (HHLA2; also known as B7-H7/B7 homolog 7). HHLA2 is a member of the B7 family of immune regulatory proteins. Mature human HHLA2 consists of an extracellular domain (ECD) with three immunoglobulin-like domains, a transmembrane segment, and a cytoplasmic domain. HHLA2 is widely expressed in human cancers including non-small cell lung carcinoma (NSCLS), triple negative breast cancer (TNBC), and melanoma, but has limited expression on normal tissues. Interestingly, unlike other members of B7 family, HHLA2 is not expressed in mice or rats. HHLA2 functions as a T cell coinhibitory molecules as it inhibits the proliferation of activated CD4(+) and CD8(+) T cells and their cytokine production. Furthermore, HHLA2 is constitutively expressed on the surface of human monocytes and is induced on B cells after stimulation, however it is not inducible on T cells.


Pssm-ID: 409512  Cd Length: 107  Bit Score: 47.38  E-value: 3.49e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568929272  47 LSCQVIPPHSVMhmeVRWFRSGHSQPVYLYRGGHKMSEEAAPEYANRTEFVKEAIGEGKVSLRIHNINILDDGPYQC 123
Cdd:cd16091   17 LPCSFTPGSEVV---IHWYKQDSDIKVHSYYYGKDQLESQDQRYRNRTSLFKDQISNGNASLLLRRVQLQDEGRYKC 90
IgV_CD86 cd16087
Immunoglobulin variable domain (IgV) in Cluster of Differentiation (CD) 86; The members here ...
 36-123 5.54e-07

Immunoglobulin variable domain (IgV) in Cluster of Differentiation (CD) 86; The members here are composed of the immunoglobulin variable region (IgV) in the Cluster of Differentiation (CD) 86). Glycoproteins B7-1 (also known as cluster of differentiation (CD) 80) and B7-2 (also known as CD86) are expressed on antigen-presenting cells and deliver the co-stimulatory signal through CD28 and CTLA-4 (also known as CD152) on T cells. signaling through CD28 augments the T-cell response, whereas CTLA-4 signaling attenuates it. The CTLA-4 and B7-2 monomers are both two-layer beta-sandwiches that display the chain topology characteristic of the immunoglobulin variable (V-type) domains present in antigen receptors. The front and back sheets of B7-2 are composed of AGFCC'C" and BED strands, respectively. Members of the IgV family are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond.


Pssm-ID: 409508  Cd Length: 108  Bit Score: 46.94  E-value: 5.54e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929272  36 HLLARVGGQAELSCQVIPPH--SVMHMEVRWfRSGHSQPVY-LYRGGHKmSEEAAPEYANRTEFVKEaigegKVSLRIHN 112
Cdd:cd16087    2 KIQAYFNETAYLPCQFKNPQniSLSELVVFW-QDQKKLVLYeLYLGKEK-LDNVNSKYIGRTSFDQE-----NWTLQLHN 74

                         90
                 ....*....|.
gi 568929272 113 INILDDGPYQC 123
Cdd:cd16087   75 VQIKDQGTYQC 85
IgV_1_Nectin-2_NecL-5_like_CD112_CD155 cd20989
First immunoglobulin variable (IgV) domain of nectin-2, nectin-like protein 5, and similar ...
 28-128 5.91e-07

First immunoglobulin variable (IgV) domain of nectin-2, nectin-like protein 5, and similar domains; The members here are composed of the second immunoglobulin (Ig) domain of nectin-2 (also known as poliovirus receptor related protein 2 or Cluster of Differentiation 112 (CD112)), nectin-like protein 5 (CD155), and similar proteins. Nectins and Nectin-like molecules are a family of Ca(2+)-independent immunoglobulin-like transmembrane glycoproteins belonging to the class of adhesion receptors, consisting of nine members (nectins 1 through 4 and nectin-like proteins 1 through 5). Nectins are synaptic cell adhesion molecules (CAMs) which facilitate adhesion and signaling at various intracellular junctions. Nectins form homophilic cis-dimers, followed by homophilic and heterophilic trans-dimers involved in cell-cell adhesion. Nectin-2 and nectin-3 localize at Sertoli-spermatid junctions where they form heterophilic trans-interactions between the cells that are essential for the formation and maintenance of the junctions and for spermatid development. CD155 is the fifth member in the nectin-like molecule family, and functions as the receptor of poliovirus; therefore, CD155 is also referred to as Necl-5, or PVR. In contrast to all other family members, CD155 lacks self-adhesion capacity, yet it shares with nectins the feature to interact with other nectins. For instance, CD155 heterophilically trans-interacts with nectin-3, thereby contributing significantly to the establishment of adherens junctions between epithelial cells. This group belongs to the Constant 1 (C1)-set of IgSF domains, which has one beta-sheet that is formed by strands A-B-E-D and the other strands by G-F-C-C'.


Pssm-ID: 409581  Cd Length: 112  Bit Score: 46.80  E-value: 5.91e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929272  28 LRVTTPTrHLLARVGGQAELSCQVIPPHSVMHM-EVRWFRSGHSQPVYLYrggHKMSEEAAPEyANRTEFVKEAIGEG-- 104
Cdd:cd20989    1 VRVQVPP-EVRGFLGGSVTLPCHLLPPNMVTHVsQVTWQRHDEHGSVAVF---HPKQGPSFPE-SERLSFVAARLGAElr 75

                         90       100
                 ....*....|....*....|....*...
gi 568929272 105 KVSLRIHNINILDDGPYQCSF----NGS 128
Cdd:cd20989   76 NASLAMFGLRVEDEGNYTCEFatfpQGS 103
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 37-141 8.83e-07

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 46.30  E-value: 8.83e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929272   37 LLARVGGQAELSCQVIPPHSVMHMEVRWFR----SGHSQPVYLYRGGHKMseeaaPEYANRTEFvKEAIGEGKVSLRIHN 112
Cdd:pfam07686   6 VTVALGGSVTLPCTYSSSMSEASTSVYWYRqppgKGPTFLIAYYSNGSEE-----GVKKGRFSG-RGDPSNGDGSLTIQN 79

                          90       100       110
                  ....*....|....*....|....*....|
gi 568929272  113 INILDDGPYQCSFNGSG-FIDAAIMNLNVT 141
Cdd:pfam07686  80 LTLSDSGTYTCAVIPSGeGVFGKGTRLTVL 109
IGv smart00406
Immunoglobulin V-Type;
45-125 1.93e-06

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 44.68  E-value: 1.93e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929272    45 AELSCQViPPHSVMHMEVRWFRSGHSQPVY-LYRGGHKMSEEAAPEYANRTEFVKEAiGEGKVSLRIHNINILDDGPYQC 123
Cdd:smart00406   2 VTLSCKF-SGSTFSSYYVSWVRQPPGKGLEwLGYIGSNGSSYYQESYKGRFTISKDT-SKNDVSLTISNLRVEDTGTYYC 79


                   ..
gi 568929272   124 SF 125
Cdd:smart00406  80 AV 81
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 35-140 5.54e-05

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 40.57  E-value: 5.54e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929272    35 RHLLARVGGQAELSCQVIPPHSVmhmEVRWFRSGHSQPvyLYRGGHKMSEEaapeyanrtefvkeaigEGKVSLRIHNIN 114
Cdd:smart00410   2 PSVTVKEGESVTLSCEASGSPPP---EVTWYKQGGKLL--AESGRFSVSRS-----------------GSTSTLTISNVT 59

                           90       100
                   ....*....|....*....|....*.
gi 568929272   115 ILDDGPYQCSFNGSGFIDAAIMNLNV 140
Cdd:smart00410  60 PEDSGTYTCAATNSSGSASSGTTLTV 85
I-set pfam07679
Immunoglobulin I-set domain;
29-123 5.78e-05

Immunoglobulin I-set domain;


Pssm-ID: 400151 [Multi-domain]  Cd Length: 90  Bit Score: 40.70  E-value: 5.78e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929272   29 RVTTPTRHLLARVGGQAELSCQVI--PPhsvmhMEVRWFRsghsqpvylyrGGHKMSEEaapeyaNRTEFVKEaigEGKV 106
Cdd:pfam07679   2 KFTQKPKDVEVQEGESARFTCTVTgtPD-----PEVSWFK-----------DGQPLRSS------DRFKVTYE---GGTY 56

                          90
                  ....*....|....*..
gi 568929272  107 SLRIHNINILDDGPYQC 123
Cdd:pfam07679  57 TLTISNVQPDDSGKYTC 73
IgV_1_MRC-OX-2_like cd05846
First immunoglobulin (Ig) variable (V) domain of rat MRC OX-2 antigen, and similar domains; ...
 28-140 2.53e-04

First immunoglobulin (Ig) variable (V) domain of rat MRC OX-2 antigen, and similar domains; The members here are composed of the first immunoglobulin (Ig) domain of rat MRC OX-2 antigen (also known as CD200) and similar proteins. MRC OX-2 is a membrane glycoprotein expressed in a variety of lymphoid and non-lymphoid cells in rats. It has a similar broad distribution pattern in humans. MRC OX-2 may regulate myeloid cell activity. The protein has an extracellular portion containing two Ig-like domains, a transmembrane portion, and a cytoplasmic portion.


Pssm-ID: 409433  Cd Length: 108  Bit Score: 39.25  E-value: 2.53e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929272  28 LRVTTPTRhllARVGGQAELSCQVIPPHSVMhmEVRWFRSGHSQPVYLYRGGHKMSEEAAPEYANRTEFvkEAIGEGKVS 107
Cdd:cd05846    2 VVHTGDTR---AVLGGNATLSCNLTLPEEVL--QVTWQKIKASSPENIVTYSKKYGVKIQPSYVRRISF--TSSGLNSTS 74

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 568929272 108 LRIHNINILDDGPYQCSFN--GSGFIDAAiMNLNV 140
Cdd:cd05846   75 ITIWNVTLEDEGCYKCLFNtfPDGIKSGT-ACLTV 108
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 27-123 3.30e-04

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 38.32  E-value: 3.30e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929272   27 KLRVTTPTRHLLARVGGQAELSCQVipphsvmhmevrwfrSGHSQPVYL-YRGGHKMSEEAAPeyanrtefvKEAIGEGK 105
Cdd:pfam13927   1 KPVITVSPSSVTVREGETVTLTCEA---------------TGSPPPTITwYKNGEPISSGSTR---------SRSLSGSN 56

                          90
                  ....*....|....*...
gi 568929272  106 VSLRIHNINILDDGPYQC 123
Cdd:pfam13927  57 STLTISNVTRSDAGTYTC 74
IgV_1_DNAM-1_like cd05889
First immunoglobulin variable (IgV) domain of DNAX accessory molecule 1, and similar domains; ...
 61-125 2.69e-03

First immunoglobulin variable (IgV) domain of DNAX accessory molecule 1, and similar domains; The members here are composed of the first immunoglobulin (Ig) domain of DNAX accessory molecule 1 (DNAM-1, also known as CD226). DNAM-1 is a transmembrane protein having two Ig-like domains. It is an adhesion molecule which plays a part in tumor-directed cytotoxicity and adhesion in natural killer (NK) cells and T lymphocytes. It has been shown to regulate the NK cell killing of several tumor types, including myeloma cells and ovarian carcinoma cells. DNAM-1 interacts specifically with poliovirus receptor (PVR; CD155) and nectin -2 (CD211), other members of the Ig superfamily. DNAM-1 is expressed in most peripheral T cells, NK cells, monocytes and a subset of B lymphocytes.


Pssm-ID: 409472  Cd Length: 111  Bit Score: 36.38  E-value: 2.69e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568929272  61 EVRWFR-SGHSQPVYLYRGGHKMSEEaaPEYANRTEFVKEAIGEGKVSLRIHNINILDDGPYQCSF 125
Cdd:cd05889   31 QVEWTKiGGQKDNIAVYHPTHGMHIR--KPYAGRVYFLNSTMASNNMSLSFRNASEDDVGYYSCSL 94
Ig_LP_like cd05877
Immunoglobulin (Ig)-like domain of human cartilage link protein (LP), and similar domains; The ...
 37-144 4.27e-03

Immunoglobulin (Ig)-like domain of human cartilage link protein (LP), and similar domains; The members here are composed of the immunoglobulin (Ig)-like domain similar to that found in human cartilage link protein (LP; also called hyaluronan and proteoglycan link protein). In cartilage, chondroitin-keratan sulfate proteoglycan (CSPG), aggrecan, forms cartilage link protein stabilized aggregates with hyaluronan (HA). These aggregates contribute to the tissue's load bearing properties. Aggregates having other CSPGs substituting for aggrecan may contribute to the structural integrity of many different tissues. Members of the vertebrate HPLN (hyaluronan/HA and proteoglycan binding link) protein family are physically linked adjacent to CSPG genes.


Pssm-ID: 409461  Cd Length: 117  Bit Score: 36.15  E-value: 4.27e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929272  37 LLARVGGQAELSC------QVIPPHsvmHMEVRWFR----SGHSQPVYLYRGGHKMSeeaAPEYANRTeFVKEAiGEGKV 106
Cdd:cd05877    7 VFSHRGGNVTLPCryhyepELSAPR---KIRVKWTKlevdYAKEEDVLVAIGTRHKS---YGSYQGRV-FLRRA-DDLDA 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 568929272 107 SLRIHNINILDDGPYQCSfngsgFID-----AAIMNLNVTAVG 144
Cdd:cd05877   79 SLVITDLRLEDYGRYRCE-----VIDgledeSVVVALRLRGVV 116
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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