NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|568933535|ref|XP_006503685|]
View 

spondin-2 isoform X1 [Mus musculus]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
Spond_N pfam06468
Spondin_N; This conserved region is found at the in the N-terminal half of several Spondin ...
40-234 3.25e-118

Spondin_N; This conserved region is found at the in the N-terminal half of several Spondin proteins. Spondins are involved in patterning axonal growth trajectory through either inhibiting or promoting adhesion of embryonic nerve cells.


:

Pssm-ID: 461924  Cd Length: 192  Bit Score: 338.79  E-value: 3.25e-118
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933535   40 ARYSITFIGKWSQTAFPKQYPLFRPpaQWSSLLGAAHSSDYSMWRKNEYVSNGLRDFAERGEAWALMKEIEaagEKLQSV 119
Cdd:pfam06468   1 AKYELTFEGLWSRTTHPKDYPLWRP--HWSDLIGASHSSDYRLWEYGQYASEGVKQFAEWGSTKKLETELK---AKSDSV 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933535  120 HAVFSAPAI-PSGTGQTSTELEVHPRHSLVSFVVRIVPSPDWFVGIDSLDLCE-GGRWKEQVVLDLYPHDAGTDSGFTFS 197
Cdd:pfam06468  76 RTIIKAPGIwPNGTGKTSAEFRVDRNHHLVSLVSMIGPSPDWFVGVDSLNLCLkNCTWIDSVTLDLYPWDAGTDSGFTYT 155
                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 568933535  198 SPNFATIPQDTVTEITASSPSHPANSFYYPRLKSLPP 234
Cdd:pfam06468 156 SPNFPTIPQEPIRRITSSYPNHPASPFYYPNGKSLPP 192
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
277-329 3.98e-18

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


:

Pssm-ID: 465948  Cd Length: 52  Bit Score: 76.93  E-value: 3.98e-18
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 568933535  277 CEVSLWSSWGLCGGPCGKlGAKSRTRYVRVQPANNGTPCPELEEEAECAPDNC 329
Cdd:pfam19028   1 CVVSEWSEWSECSVTCGG-GVQTRTRTVIVEPQNGGRPCPELLERRPCNLPPC 52
 
Name Accession Description Interval E-value
Spond_N pfam06468
Spondin_N; This conserved region is found at the in the N-terminal half of several Spondin ...
40-234 3.25e-118

Spondin_N; This conserved region is found at the in the N-terminal half of several Spondin proteins. Spondins are involved in patterning axonal growth trajectory through either inhibiting or promoting adhesion of embryonic nerve cells.


Pssm-ID: 461924  Cd Length: 192  Bit Score: 338.79  E-value: 3.25e-118
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933535   40 ARYSITFIGKWSQTAFPKQYPLFRPpaQWSSLLGAAHSSDYSMWRKNEYVSNGLRDFAERGEAWALMKEIEaagEKLQSV 119
Cdd:pfam06468   1 AKYELTFEGLWSRTTHPKDYPLWRP--HWSDLIGASHSSDYRLWEYGQYASEGVKQFAEWGSTKKLETELK---AKSDSV 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933535  120 HAVFSAPAI-PSGTGQTSTELEVHPRHSLVSFVVRIVPSPDWFVGIDSLDLCE-GGRWKEQVVLDLYPHDAGTDSGFTFS 197
Cdd:pfam06468  76 RTIIKAPGIwPNGTGKTSAEFRVDRNHHLVSLVSMIGPSPDWFVGVDSLNLCLkNCTWIDSVTLDLYPWDAGTDSGFTYT 155
                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 568933535  198 SPNFATIPQDTVTEITASSPSHPANSFYYPRLKSLPP 234
Cdd:pfam06468 156 SPNFPTIPQEPIRRITSSYPNHPASPFYYPNGKSLPP 192
NF038123_dom NF038123
spondin domain;
40-242 5.69e-33

spondin domain;


Pssm-ID: 468366  Cd Length: 208  Bit Score: 121.33  E-value: 5.69e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933535  40 ARYSITFIGKWSQTAFPkqyplfrppaqWSSLLGAAHSSDYSMWRKNEYVSNGLRDFAERGEAWALMKEI-EAAGEKLQS 118
Cdd:NF038123   1 ATYTVTITNLTPPNGQP-----------FSPLVVAAHNGNFDLFEVGEPASEGLERLAEGGDPSGLLSALaDQAGVVVVA 69
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933535 119 VHAvfSAPAIPSGTGQTSTELEVHPRHSLvSFVVRIVPSPDWFVGIDSLDLCEGGRwKEQVVLDLYPHDAGTDS------ 192
Cdd:NF038123  70 VPG--GGPLAPGASESVSFTFEAADGDYL-SLATMLVPSNDWFVGLDSLDLFDLAG-GGTVTLSLNAYDAGTEAndepev 145
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568933535 193 --------GFTFSSPNFATIPQDTVTEITASSPSHPA----NSFYYPRLKSLPPIAKVTFVR 242
Cdd:NF038123 146 nipgpaggGEGFNGAGPDTDENGVVAIHPGVPGDDDAdggiSDVLNPNHRFDNPVAKVVITR 207
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
277-329 3.98e-18

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 76.93  E-value: 3.98e-18
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 568933535  277 CEVSLWSSWGLCGGPCGKlGAKSRTRYVRVQPANNGTPCPELEEEAECAPDNC 329
Cdd:pfam19028   1 CVVSEWSEWSECSVTCGG-GVQTRTRTVIVEPQNGGRPCPELLERRPCNLPPC 52
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
279-329 6.53e-07

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 45.66  E-value: 6.53e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 568933535   279 VSLWSSWGLCGGPCGKlGAKSRTRY-VRVQPANNGTPCPELEEEAE-CAPDNC 329
Cdd:smart00209   1 WSEWSEWSPCSVTCGG-GVQTRTRScCSPPPQNGGGPCTGEDVETRaCNEQPC 52
 
Name Accession Description Interval E-value
Spond_N pfam06468
Spondin_N; This conserved region is found at the in the N-terminal half of several Spondin ...
40-234 3.25e-118

Spondin_N; This conserved region is found at the in the N-terminal half of several Spondin proteins. Spondins are involved in patterning axonal growth trajectory through either inhibiting or promoting adhesion of embryonic nerve cells.


Pssm-ID: 461924  Cd Length: 192  Bit Score: 338.79  E-value: 3.25e-118
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933535   40 ARYSITFIGKWSQTAFPKQYPLFRPpaQWSSLLGAAHSSDYSMWRKNEYVSNGLRDFAERGEAWALMKEIEaagEKLQSV 119
Cdd:pfam06468   1 AKYELTFEGLWSRTTHPKDYPLWRP--HWSDLIGASHSSDYRLWEYGQYASEGVKQFAEWGSTKKLETELK---AKSDSV 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933535  120 HAVFSAPAI-PSGTGQTSTELEVHPRHSLVSFVVRIVPSPDWFVGIDSLDLCE-GGRWKEQVVLDLYPHDAGTDSGFTFS 197
Cdd:pfam06468  76 RTIIKAPGIwPNGTGKTSAEFRVDRNHHLVSLVSMIGPSPDWFVGVDSLNLCLkNCTWIDSVTLDLYPWDAGTDSGFTYT 155
                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 568933535  198 SPNFATIPQDTVTEITASSPSHPANSFYYPRLKSLPP 234
Cdd:pfam06468 156 SPNFPTIPQEPIRRITSSYPNHPASPFYYPNGKSLPP 192
NF038123_dom NF038123
spondin domain;
40-242 5.69e-33

spondin domain;


Pssm-ID: 468366  Cd Length: 208  Bit Score: 121.33  E-value: 5.69e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933535  40 ARYSITFIGKWSQTAFPkqyplfrppaqWSSLLGAAHSSDYSMWRKNEYVSNGLRDFAERGEAWALMKEI-EAAGEKLQS 118
Cdd:NF038123   1 ATYTVTITNLTPPNGQP-----------FSPLVVAAHNGNFDLFEVGEPASEGLERLAEGGDPSGLLSALaDQAGVVVVA 69
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933535 119 VHAvfSAPAIPSGTGQTSTELEVHPRHSLvSFVVRIVPSPDWFVGIDSLDLCEGGRwKEQVVLDLYPHDAGTDS------ 192
Cdd:NF038123  70 VPG--GGPLAPGASESVSFTFEAADGDYL-SLATMLVPSNDWFVGLDSLDLFDLAG-GGTVTLSLNAYDAGTEAndepev 145
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568933535 193 --------GFTFSSPNFATIPQDTVTEITASSPSHPA----NSFYYPRLKSLPPIAKVTFVR 242
Cdd:NF038123 146 nipgpaggGEGFNGAGPDTDENGVVAIHPGVPGDDDAdggiSDVLNPNHRFDNPVAKVVITR 207
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
277-329 3.98e-18

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 76.93  E-value: 3.98e-18
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 568933535  277 CEVSLWSSWGLCGGPCGKlGAKSRTRYVRVQPANNGTPCPELEEEAECAPDNC 329
Cdd:pfam19028   1 CVVSEWSEWSECSVTCGG-GVQTRTRTVIVEPQNGGRPCPELLERRPCNLPPC 52
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
279-329 6.53e-07

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 45.66  E-value: 6.53e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 568933535   279 VSLWSSWGLCGGPCGKlGAKSRTRY-VRVQPANNGTPCPELEEEAE-CAPDNC 329
Cdd:smart00209   1 WSEWSEWSPCSVTCGG-GVQTRTRScCSPPPQNGGGPCTGEDVETRaCNEQPC 52
TSP_1 pfam00090
Thrombospondin type 1 domain;
280-329 1.74e-03

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 35.86  E-value: 1.74e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 568933535  280 SLWSSWGLCGGPCGKlGAKSRTRYVrVQPANNGTPCPELEEEAE-CAPDNC 329
Cdd:pfam00090   1 SPWSPWSPCSVTCGK-GIQVRQRTC-KSPFPGGEPCTGDDIETQaCKMDKC 49
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH