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Conserved domains on  [gi|755514450|ref|XP_006504558|]
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uroplakin-3b-like protein 1 isoform X1 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
UP_III_II super family cl06408
Uroplakin IIIb, IIIa and II; Uroplakins (UPs) are a family of proteins that associate with ...
 28-201 1.36e-72

Uroplakin IIIb, IIIa and II; Uroplakins (UPs) are a family of proteins that associate with each other to form plaques on the apical surface of the urothelium, the pseudo-stratified epithelium lining the urinary tract from renal pelvis to the bladder outlet. UPs are classified into 3 types: UPIa and UPIb, UPII, and UPIIIa and IIIb. UPIs are tetraspanins that have four transmembrane domains separating one large and one small extracellular domain while UPII and UPIIIs are single-pass transmembrane proteins. UPIa and UPIb form specific heterodimers with UPII and UPIII, respectively, which allows them to exit the endoplasmatic rediculum. UPII/UPIa and UPIIIs/UPIb form heterotetramers; six of these tetramers form the 16nm particle, seen in the hexagonal array of the asymmetric unit membrane, which is believed to form a urinary tract barrier. Uroplakins are also believed to play a role during urinary tract morphogenesis.


The actual alignment was detected with superfamily member cd09969:

Pssm-ID: 471435  Cd Length: 184  Bit Score: 218.41  E-value: 1.36e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755514450  28 ESINYAPQLLGATLEGRLTQSTFTLEQPLGQFKNvnLSDPDPIWLVVAHSNAAQNFTAPRKVEDRHAPANFDRNGYYLTL 107
Cdd:cd09969    1 EKISYVPQLTPAPLEGRITSSTFVLEQPRCVFSS--SSDGDDIWLVVALSNATQNFNAPVKSSDIPTASSFSTKGYYLTL 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755514450 108 RANRVHYKGGQPDSQLRVLRVGNDNNCSleSQGCNSPLPGAGPYRVKFLAMSAEGPVAETLWSEEIYLQQA---QTFREA 184
Cdd:cd09969   79 RASRALYPCGNPSMGLPVLRVGADTGCT--DNNCNGPLPGPGPYRVKFLVMNNRGPVAETNWSDPITLRTGkspQTIDTW 156

                        170
                 ....*....|....*..
gi 755514450 185 PGSQGKGTVVIIAFLSI 201
Cdd:cd09969  157 PGRRSGGMIVITTILSV 173
 
Name Accession Description Interval E-value
UP_IIIb cd09969
Uroplakin IIIb; Uroplakin IIIb, minor isoform of the dimerization partner of uroplakin Ib, is ...
 28-201 1.36e-72

Uroplakin IIIb; Uroplakin IIIb, minor isoform of the dimerization partner of uroplakin Ib, is a members of the uroplakin family. Uroplakins (UPs) are a family of proteins that associate with each other to form plaques on the apical surface of the urothelium, the pseudo-stratified epithelium lining the urinary tract from renal pelvis to the bladder outlet. UPs are classified into 3 types: UPIa and UPIb, UPII, and UPIIIa and IIIb. UPIs are tetraspanins that have four transmembrane domains seperating one large and one small extracellular domain while UPII and UPIIIs are single-pass transmembrane proteins. UPIa and UPIb form specific heterodimers with UPII and UPIII, respectively, which allows them to exit the endoplasmatic rediculum. UPII/UPIa and UPIIIs/UPIb form heterotetramers and six of these tetramers form the 16nm particle, seen in the hexagonal array of the asymmetric unit membrane, which is believed to form a urinary tract barrier. Uroplakins are also believed to play a role during urinary tract morphogenesis.


Pssm-ID: 197378  Cd Length: 184  Bit Score: 218.41  E-value: 1.36e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755514450  28 ESINYAPQLLGATLEGRLTQSTFTLEQPLGQFKNvnLSDPDPIWLVVAHSNAAQNFTAPRKVEDRHAPANFDRNGYYLTL 107
Cdd:cd09969    1 EKISYVPQLTPAPLEGRITSSTFVLEQPRCVFSS--SSDGDDIWLVVALSNATQNFNAPVKSSDIPTASSFSTKGYYLTL 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755514450 108 RANRVHYKGGQPDSQLRVLRVGNDNNCSleSQGCNSPLPGAGPYRVKFLAMSAEGPVAETLWSEEIYLQQA---QTFREA 184
Cdd:cd09969   79 RASRALYPCGNPSMGLPVLRVGADTGCT--DNNCNGPLPGPGPYRVKFLVMNNRGPVAETNWSDPITLRTGkspQTIDTW 156

                        170
                 ....*....|....*..
gi 755514450 185 PGSQGKGTVVIIAFLSI 201
Cdd:cd09969  157 PGRRSGGMIVITTILSV 173
 
Name Accession Description Interval E-value
UP_IIIb cd09969
Uroplakin IIIb; Uroplakin IIIb, minor isoform of the dimerization partner of uroplakin Ib, is ...
 28-201 1.36e-72

Uroplakin IIIb; Uroplakin IIIb, minor isoform of the dimerization partner of uroplakin Ib, is a members of the uroplakin family. Uroplakins (UPs) are a family of proteins that associate with each other to form plaques on the apical surface of the urothelium, the pseudo-stratified epithelium lining the urinary tract from renal pelvis to the bladder outlet. UPs are classified into 3 types: UPIa and UPIb, UPII, and UPIIIa and IIIb. UPIs are tetraspanins that have four transmembrane domains seperating one large and one small extracellular domain while UPII and UPIIIs are single-pass transmembrane proteins. UPIa and UPIb form specific heterodimers with UPII and UPIII, respectively, which allows them to exit the endoplasmatic rediculum. UPII/UPIa and UPIIIs/UPIb form heterotetramers and six of these tetramers form the 16nm particle, seen in the hexagonal array of the asymmetric unit membrane, which is believed to form a urinary tract barrier. Uroplakins are also believed to play a role during urinary tract morphogenesis.


Pssm-ID: 197378  Cd Length: 184  Bit Score: 218.41  E-value: 1.36e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755514450  28 ESINYAPQLLGATLEGRLTQSTFTLEQPLGQFKNvnLSDPDPIWLVVAHSNAAQNFTAPRKVEDRHAPANFDRNGYYLTL 107
Cdd:cd09969    1 EKISYVPQLTPAPLEGRITSSTFVLEQPRCVFSS--SSDGDDIWLVVALSNATQNFNAPVKSSDIPTASSFSTKGYYLTL 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755514450 108 RANRVHYKGGQPDSQLRVLRVGNDNNCSleSQGCNSPLPGAGPYRVKFLAMSAEGPVAETLWSEEIYLQQA---QTFREA 184
Cdd:cd09969   79 RASRALYPCGNPSMGLPVLRVGADTGCT--DNNCNGPLPGPGPYRVKFLVMNNRGPVAETNWSDPITLRTGkspQTIDTW 156

                        170
                 ....*....|....*..
gi 755514450 185 PGSQGKGTVVIIAFLSI 201
Cdd:cd09969  157 PGRRSGGMIVITTILSV 173
UP_III cd09968
Uroplakin III; Uroplakin IIIa and IIIb, the dimerization partners of uroplakin Ib, are a ...
 28-201 5.38e-66

Uroplakin III; Uroplakin IIIa and IIIb, the dimerization partners of uroplakin Ib, are a members of the uroplakin family. Uroplakins (UPs) are a family of proteins that associate with each other to form plaques on the apical surface of the urothelium, the pseudo-stratified epithelium lining the urinary tract from renal pelvis to the bladder outlet. UPs are classified into 3 types: UPIa and UPIb, UPII, and UPIIIa and IIIb. UPIs are tetraspanins that have four transmembrane domains seperating one large and one small extracellular domain while UPII and UPIIIs are single-pass transmembrane proteins. UPIa and UPIb form specific heterodimers with UPII and UPIII, respectively, which allows them to exit the endoplasmatic rediculum. UPII/UPIa and UPIIIs/UPIb form heterotetramers and six of these tetramers form the 16nm particle, seen in the hexagonal array of the asymmetric unit membrane, which is believed to form a urinary tract barrier. Uroplakins are also believed to play a role during urinary tract morphogenesis.


Pssm-ID: 197377  Cd Length: 187  Bit Score: 201.46  E-value: 5.38e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755514450  28 ESINYAPQLLGATLEGRLTQSTFTLEQPLGQFKNVNlSDPDPIWLVVAHSNAAQNFTAPRKVEDRH-APANFDRNGYYLT 106
Cdd:cd09968    1 EAVSYVPQLASTFLEGNPTSTTFTLEQPRCVFDSSA-SDTDDVWLVVAVSNATNNFNAPQNSTDPIsTYSQFSGGQYYLT 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755514450 107 LRANRVHYKGGQPDSQLRVLRVGNDNNCSlESQGCNSPLPGAGPYRVKFLAMSAEGPVAETLWSEEIYLQQA---QTFRE 183
Cdd:cd09968   80 LRASRDLYPCGNPSLNAYVLRVGADGNCT-DNGNCNGPLPGPGPYRVKYLVMNGSGVVAQTNWSDPIRLNQAksyQTIDT 158

                        170
                 ....*....|....*...
gi 755514450 184 APGSQGKGTVVIIAFLSI 201
Cdd:cd09968  159 WPGRRSGGMIVITSILSV 176
UP_III_II cd09966
Uroplakin IIIb, IIIa and II; Uroplakins (UPs) are a family of proteins that associate with ...
 30-201 1.88e-56

Uroplakin IIIb, IIIa and II; Uroplakins (UPs) are a family of proteins that associate with each other to form plaques on the apical surface of the urothelium, the pseudo-stratified epithelium lining the urinary tract from renal pelvis to the bladder outlet. UPs are classified into 3 types: UPIa and UPIb, UPII, and UPIIIa and IIIb. UPIs are tetraspanins that have four transmembrane domains separating one large and one small extracellular domain while UPII and UPIIIs are single-pass transmembrane proteins. UPIa and UPIb form specific heterodimers with UPII and UPIII, respectively, which allows them to exit the endoplasmatic rediculum. UPII/UPIa and UPIIIs/UPIb form heterotetramers; six of these tetramers form the 16nm particle, seen in the hexagonal array of the asymmetric unit membrane, which is believed to form a urinary tract barrier. Uroplakins are also believed to play a role during urinary tract morphogenesis.


Pssm-ID: 197375  Cd Length: 181  Bit Score: 177.23  E-value: 1.88e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755514450  30 INYAPQLLGATLEGRLTQSTFTLEQPLGQFKNVNLSDpdpIWLVVAHSNAAQNFTAPRKVEDRHAPANFDRNGYYLTLRA 109
Cdd:cd09966    1 LSYVPQLTASTGAGNPTLSTFTLEQPPCMFDSSSTDD---VWLVVALPNATLAFQNVTLSTDISTYLTFTTGNYYKTLRA 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755514450 110 NRVHYKGGQPDS--QLRVLRVGNDNNCSleSQGCNSPLPGAGPYRVKFLAMSAEGPVAETLWSEEIYLQQAQTFREA-PG 186
Cdd:cd09966   78 SFDLPPCRNRRDivSAYVLRVGNTTTCL--SGYCNTPLPGPGPYRVKYLVMNGSGPSAQTEWSTPIRLNQNKIYSTTwPG 155

                        170
                 ....*....|....*
gi 755514450 187 SQGKGTVVIIAFLSI 201
Cdd:cd09966  156 ARSGGMIVITVILSV 170
UP_IIIa cd09970
Uroplakin IIIa; Uroplakin IIIa, mayor isoform of the dimerization partner of uroplakin Ib, is ...
 29-200 1.82e-06

Uroplakin IIIa; Uroplakin IIIa, mayor isoform of the dimerization partner of uroplakin Ib, is a members of the uroplakin family. Uroplakins (UPs) are a family of proteins that associate with each other to form plaques on the apical surface of the urothelium, the pseudo-stratified epithelium lining the urinary tract from renal pelvis to the bladder outlet. UPs are classified into 3 types: UPIa and UPIb, UPII, and UPIIIa and IIIb. UPIs are tetraspanins that have four transmembrane domains seperating one large and one small extracellular domain while UPII and UPIIIs are single-pass transmembrane proteins. UPIa and UPIb form specific heterodimers with UPII and UPIII, respectively, which allows them to exit the endoplasmatic rediculum. UPII/UPIa and UPIIIs/UPIb form heterotetramers and six of these tetramers form the 16nm particle, seen in the hexagonal array of the asymmetric unit membrane, which is believed to form a urinary tract barrier. Uroplakins are also believed to play a role during urinary tract morphogenesis.


Pssm-ID: 197379  Cd Length: 212  Bit Score: 46.90  E-value: 1.82e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755514450  29 SINYAPQLLGATL-EGRLTQSTFTLEQPLGQFKNVNLSDPDPIWLVVAHSNAAQNftapRKVEDRhAPANFDRNGYYL-T 106
Cdd:cd09970    2 AVNLQPQLASVTFaTNNPTLTTITLEKPFCMFDSKEALTGTHEVYLYVLVDSAIS----RNASVQ-DSTNTPLGSTFLqT 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755514450 107 LRANRVHYKGGQPD----SQLRVL------------------RVGNDNNCSLES--QG-CNSPLPGAGPYRVKFLAMSAE 161
Cdd:cd09970   77 EGGRTGPYKAAAFDlppcSDLPSLdaigdvskasqilnaylvRVGANGTCLWDPnfKGlCNPPLSAATEYRFKYVLVNMS 156

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 755514450 162 GPVAE--TLWSEEIYLQQAQTFREA---PGSQGKGTVVIIAFLS 200
Cdd:cd09970  157 TGLVEdqTLWSDPIRTNQLTPYSTIdtwPGRRSGGMIVITSILS 200
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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