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Conserved domains on  [gi|568941254|ref|XP_006505891|]
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aldo-keto reductase family 1 member D1 isoform X7 [Mus musculus]

Protein Classification

aldo-keto reductase family protein( domain architecture ID 305)

aldo-keto reductase family protein may be an NAD(P)(H) oxidoreductase that reduces aldehydes and ketones to primary and secondary alcohols

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AKR_SF super family cl00470
Aldo-keto reductase (AKR) superfamily; Aldo-keto reductases (AKRs) are a superfamily of ...
 33-143 4.09e-72

Aldo-keto reductase (AKR) superfamily; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications. Members have very distinct functions and include the prokaryotic 2,5-diketo-D-gluconic acid reductases and beta-keto ester reductases, the eukaryotic aldose reductases, aldehyde reductases, hydroxysteroid dehydrogenases, steroid 5beta-reductases, potassium channel beta-subunits, and aflatoxin aldehyde reductases, among others.


The actual alignment was detected with superfamily member cd19109:

Pssm-ID: 444925 [Multi-domain]  Cd Length: 308  Bit Score: 220.06  E-value: 4.09e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941254  33 GNNIPLIGLGTYSDPR-PVPGKTYVAVKTAIDEGYRHIDGAYVYHNEHEVGEAIREKIAEGKVKREEIFYCGKLWNTEHV 111
Cdd:cd19109    1 GNSIPIIGLGTYSEPKtTPKGACAEAVKVAIDTGYRHIDGAYIYQNEHEVGQAIREKIAEGKVKREDIFYCGKLWNTCHP 80

                         90       100       110
                 ....*....|....*....|....*....|..
gi 568941254 112 PSMVLPALERTLKALKLDYIDLYIIELPMAFK 143
Cdd:cd19109   81 PELVRPTLERTLKVLQLDYVDLYIIEMPMAFK 112
 
Name Accession Description Interval E-value
AKR_AKR1D1-3 cd19109
AKR1D family of aldo-keto reductase (AKR); The AKR1D family of aldo-keto reductase includes ...
 33-143 4.09e-72

AKR1D family of aldo-keto reductase (AKR); The AKR1D family of aldo-keto reductase includes 3-oxo-5-beta-steroid 4-dehydrogenase (EC 1.3.1.3) from Homo sapiens (AKR1D1), Rattus norvegicus (liver, AKR1D2), and Oryctolagus cuniculus (AKR1D3). 3-oxo-5-beta-steroid 4-dehydrogenase, also called delta(4)-3-ketosteroid 5-beta-reductase (EC 1.3.99.6), or delta(4)-3-oxosteroid 5-beta-reductase, or 5-beta-reductase, efficiently catalyzes the reduction of progesterone, androstenedione, 17-alpha-hydroxyprogesterone and testosterone to 5-beta-reduced metabolites.


Pssm-ID: 381335 [Multi-domain]  Cd Length: 308  Bit Score: 220.06  E-value: 4.09e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941254  33 GNNIPLIGLGTYSDPR-PVPGKTYVAVKTAIDEGYRHIDGAYVYHNEHEVGEAIREKIAEGKVKREEIFYCGKLWNTEHV 111
Cdd:cd19109    1 GNSIPIIGLGTYSEPKtTPKGACAEAVKVAIDTGYRHIDGAYIYQNEHEVGQAIREKIAEGKVKREDIFYCGKLWNTCHP 80

                         90       100       110
                 ....*....|....*....|....*....|..
gi 568941254 112 PSMVLPALERTLKALKLDYIDLYIIELPMAFK 143
Cdd:cd19109   81 PELVRPTLERTLKVLQLDYVDLYIIEMPMAFK 112
ARA1 COG0656
Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, ...
 32-136 1.48e-38

Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440421 [Multi-domain]  Cd Length: 259  Bit Score: 132.49  E-value: 1.48e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941254  32 DGNNIPLIGLGTYsdpRPVPGKTYVAVKTAIDEGYRHIDGAYVYHNEHEVGEAIRekiaEGKVKREEIFYCGKLWNTEHV 111
Cdd:COG0656    1 NGVEIPALGLGTW---QLPGEEAAAAVRTALEAGYRHIDTAAMYGNEEGVGEAIA----ASGVPREELFVTTKVWNDNHG 73

                         90       100
                 ....*....|....*....|....*
gi 568941254 112 PSMVLPALERTLKALKLDYIDLYII 136
Cdd:COG0656   74 YDDTLAAFEESLERLGLDYLDLYLI 98
dkgA PRK11565
2,5-didehydrogluconate reductase DkgA;
28-145 7.14e-26

2,5-didehydrogluconate reductase DkgA;


Pssm-ID: 183203 [Multi-domain]  Cd Length: 275  Bit Score: 100.15  E-value: 7.14e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941254  28 ISLSDGNNIPLIGLGTY--SDPRPVpgktyVAVKTAIDEGYRHIDGAYVYHNEHEVGEAIRekiaEGKVKREEIFYCGKL 105
Cdd:PRK11565   7 IKLQDGNVMPQLGLGVWqaSNEEVI-----TAIHKALEVGYRSIDTAAIYKNEEGVGKALK----EASVAREELFITTKL 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 568941254 106 WNTEHvpSMVLPALERTLKALKLDYIDLYIIELPMAFKET 145
Cdd:PRK11565  78 WNDDH--KRPREALEESLKKLQLDYVDLYLMHWPVPAIDH 115
Aldo_ket_red pfam00248
Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain ...
 39-134 1.69e-15

Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain regulatory domains - these are reported to have oxidoreductase activity.


Pssm-ID: 425554 [Multi-domain]  Cd Length: 290  Bit Score: 72.34  E-value: 1.69e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941254   39 IGLGTYS----DPRPVPGKTYVAVKTAIDEGYRHIDGAYVYH---NEHEVGEAIREKiaegKVKREEIFYCGKL------ 105
Cdd:pfam00248   1 IGLGTWQlgggWGPISKEEALEALRAALEAGINFIDTAEVYGdgkSEELLGEALKDY----PVKRDKVVIATKVpdgdgp 76

                          90       100
                  ....*....|....*....|....*....
gi 568941254  106 WNTEHVPSMVLPALERTLKALKLDYIDLY 134
Cdd:pfam00248  77 WPSGGSKENIRKSLEESLKRLGTDYIDLY 105
 
Name Accession Description Interval E-value
AKR_AKR1D1-3 cd19109
AKR1D family of aldo-keto reductase (AKR); The AKR1D family of aldo-keto reductase includes ...
 33-143 4.09e-72

AKR1D family of aldo-keto reductase (AKR); The AKR1D family of aldo-keto reductase includes 3-oxo-5-beta-steroid 4-dehydrogenase (EC 1.3.1.3) from Homo sapiens (AKR1D1), Rattus norvegicus (liver, AKR1D2), and Oryctolagus cuniculus (AKR1D3). 3-oxo-5-beta-steroid 4-dehydrogenase, also called delta(4)-3-ketosteroid 5-beta-reductase (EC 1.3.99.6), or delta(4)-3-oxosteroid 5-beta-reductase, or 5-beta-reductase, efficiently catalyzes the reduction of progesterone, androstenedione, 17-alpha-hydroxyprogesterone and testosterone to 5-beta-reduced metabolites.


Pssm-ID: 381335 [Multi-domain]  Cd Length: 308  Bit Score: 220.06  E-value: 4.09e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941254  33 GNNIPLIGLGTYSDPR-PVPGKTYVAVKTAIDEGYRHIDGAYVYHNEHEVGEAIREKIAEGKVKREEIFYCGKLWNTEHV 111
Cdd:cd19109    1 GNSIPIIGLGTYSEPKtTPKGACAEAVKVAIDTGYRHIDGAYIYQNEHEVGQAIREKIAEGKVKREDIFYCGKLWNTCHP 80

                         90       100       110
                 ....*....|....*....|....*....|..
gi 568941254 112 PSMVLPALERTLKALKLDYIDLYIIELPMAFK 143
Cdd:cd19109   81 PELVRPTLERTLKVLQLDYVDLYIIEMPMAFK 112
AKR_AKR1C1-35 cd19108
AKR1C family of aldo-keto reductase (AKR); The AKR1C family of aldo-keto reductase (AKR) ...
 26-143 1.51e-55

AKR1C family of aldo-keto reductase (AKR); The AKR1C family of aldo-keto reductase (AKR) includes AKR1C1 (20-alpha-hydroxysteroid dehydrogenase, also known as 20alpha-HSD), AKR1C2 (3alpha-HSD type 3), AKR1C3 (17beta-HSD type 5), and AKR1C4 (3alpha-HSD type 1) from Homo sapiens; AKR1C5 (20alpha-HSD, also known as prostaglandin-E(2) 9-reductase) from Rattus norvegicus (ovary); AKR1C6 (estradiol 17beta-HSD type 5) from Mus musculus; AKR1C7 (prostaglandin F synthase 1 or PGF1) from Bos taurus (lung); AKR1C8 (20alpha-HSD) from Rattus norvegicus (ovary); AKR1C9 (3alpha-HSD) from Rattus norvegicus (liver); AKR1C10a (Rho crystallin) from Rana temporaria and AKR1C10b (Rho crystallin) from Rana catesbeina; AKR1C11 (prostaglandin F synthase 2 or PGF2) from Bos taurus (liver); AKR1C12 (aldo-keto reductase or AKR), AKR1C13 (interleukin-3-regulated AKR), and AKR1C14 (3alpha-HSD) from Mus musculus; AKR1C15 (NADPH-dependent reductase), AKR1C16 (NAD+-preferring 3alpha/17beta/20alpha-HSD), and AKR1C17 (NAD+-dependent 3alpha-HSD) from Rattus norvegicus; AKR1C18 (20alpha-HSD), AKR1C19 (3-hydroxybutyrate dehydrogenase or 3HB dehydrogenase), AKR1C20 (3alpha(17beta)-HSD), AKR1C21 (3(17)alpha-HSD), AKR1C22 (dihydrodiol dehydrogenase or DD) from Mus musculus; AKR1C23 (20alpha-HSD) from Equus caballus; AKR1C24 (NAD+-dependent 17beta-HSD) from Rattus norvegicus; AKR1C25 (3(20)alpha-HSD) from Macaca fuscata; AKR1C26 (identical to morphine 6-dehydrogenase or M6DH, acts as NAD(+)-dependent 3alpha/17beta-HSD), AKR1C27/AKR1C28 (NAD(+)-dependent 3alpha/17beta-HSDs), AKR1C29 (identical to 3-hydroxyhexobarbital dehydrogenase or 3HBD, acts as NADPH-preferring reductase with 3alpha/3beta/17beta/20alpha-HSD activity), AKR1C30 (identical to naloxone reductase type 1 and acts as 17beta-HSD), AKR1C31 (3alpha/17beta/20alpha-HSD), AKR1C32 (identical to loxoprofen reductase and acts as 3alpha/20alpha-HSD), and AKR1C33 (identical to naloxone reductase type 2 and mainly acts as 3alpha-HSD) from Oryctolagus cuniculus; AKR1C34 (NAD+-dependent morphine 6-dehydrogenase or M6DH with 3beta/17beta/20alpha-HSD activity) and AKR1C35 (NAD+-dependent dehydrogenase with 3(17)beta-HSD activity) from Mesocricetus auratus.


Pssm-ID: 381334 [Multi-domain]  Cd Length: 303  Bit Score: 177.42  E-value: 1.51e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941254  26 HQISLSDGNNIPLIGLGTYSdPRPVP-GKTYVAVKTAIDEGYRHIDGAYVYHNEHEVGEAIREKIAEGKVKREEIFYCGK 104
Cdd:cd19108    1 QRVKLNDGHFIPVLGFGTYA-PEEVPkSKALEATKLAIDAGFRHIDSAYLYQNEEEVGQAIRSKIADGTVKREDIFYTSK 79

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 568941254 105 LWNTEHVPSMVLPALERTLKALKLDYIDLYIIELPMAFK 143
Cdd:cd19108   80 LWCTFHRPELVRPALEKSLKKLQLDYVDLYLIHFPVALK 118
AKR_AKR2E1-5 cd19116
AKR2E family of aldo-keto reductase (AKR); Bombyx mori 3-dehydroecdysone reductase is a ...
 28-144 1.31e-54

AKR2E family of aldo-keto reductase (AKR); Bombyx mori 3-dehydroecdysone reductase is a founding member of aldo-keto reductase family 2 member E4 (AKR2E4). It is a NADP-dependent oxidoreductase with high 3-dehydroecdysone reductase activity. It may play a role in the regulation of molting and has lower activity with phenylglyoxal and isatin (in vitro). This family also includes 3-dehydroecdysone 3b-reductase from Spodoptera littoralis and Trichoplusia ni, DL-glyceraldehyde reductase from Drosophila melanogaster, aldo-keto reductase from Bombyx mori, which correspond to aldo-keto reductase family 2 member E1, E2, E3 and E5 (AKR2E1/2/3/5), respectively.


Pssm-ID: 381342 [Multi-domain]  Cd Length: 292  Bit Score: 174.78  E-value: 1.31e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941254  28 ISLSDGNNIPLIGLGTYSDPRPVPGKTyvAVKTAIDEGYRHIDGAYVYHNEHEVGEAIREKIAEGKVKREEIFYCGKLWN 107
Cdd:cd19116    3 IKLNDGNEIPAIALGTWKLKDDEGVRQ--AVKHAIEAGYRHIDTAYLYGNEAEVGEAIREKIAEGVVKREDLFITTKLWN 80

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 568941254 108 TEHVPSMVLPALERTLKALKLDYIDLYIIELPMAFKE 144
Cdd:cd19116   81 SYHEREQVEPALRESLKRLGLDYVDLYLIHWPVAFKE 117
AKR_AKR1B1-19 cd19107
AKR1B family of aldo-keto reductase (AKR); The AKR1B family of AKR includes aldose reductase ...
 33-143 4.47e-48

AKR1B family of aldo-keto reductase (AKR); The AKR1B family of AKR includes aldose reductase (AR, EC 1.1.1.21) from Homo sapiens (AKR1B1), Oryctolagus cuniculus (kidney, AKR1B2), Mus musculus (AKR1B3), Rattus norvegicus (lens, AKR1B4), Bos taurus (lens/testis, AKR1B5), and Sus scrofa (lens, AKR1B6), aldose reductase-related protein 1 (ALD1, EC1.1.1.21) from Mus musculus (AKR1B7), Rattus norvegicus (AKR1B14), and Homo sapiens (AKR1B15), Mus musculus fibroblast growth factor induced protein (FR-1 or AKR1B8, EC 1.1.1.21), Cricetulus griseus aldose reductase-related protein 2 (ALD2 or AKR1B9, EC 1.1.1.21), aldose reductase-like from Homo sapiens (ARL-1 or AKR1B10) and Rattus norvegicus (AKR1B13), aldo-keto reductase from Gallus domesticus (eye, tongue, esophagus, AKR1B12), and Oryctolagus cuniculus AR-like protein (3beta-HSD, AKR1B19). AR, also called aldehyde reductase, catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies. ALD1 reduces a broad range of aliphatic and aromatic aldehydes to the corresponding alcohols. It may play a role in the metabolism of xenobiotic aromatic aldehydes. FR-1, also called aldose reductase-related protein 2, or fibroblast growth factor-regulated protein (FGFRP), is induced by fibroblast growth factor-1. It may play a role in the regulation of the cell cycle. FR-1 belongs to the NADPH-dependent aldo-keto reductase family. ALD2 is an inducible aldo-keto reductase with a preference for aliphatic substrates. It can also act on small aromatic aldehydes, steroid aldehydes and some ketone substrates. ARL-1, also called aldose reductase-like, or aldose reductase-related protein (ARP), or small intestine reductase, or SI reductase, acts as all-trans-retinaldehyde reductase that can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro). It may be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs. AKR1B15, also called estradiol 17-beta-dehydrogenase AKR1B15, is a mitochondrial aldo-keto reductase that catalyzes the reduction of androgens and estrogens with high positional selectivity (shows 17-beta-hydroxysteroid dehydrogenase activity) as well as 3-keto-acyl-CoAs. It has a strong selectivity towards NADP(H). AKR1B19 is aldose reductase-like that may show 3-beta-hydroxysteroid dehydrogenase (3beta-HSD) activity.


Pssm-ID: 381333 [Multi-domain]  Cd Length: 307  Bit Score: 158.35  E-value: 4.47e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941254  33 GNNIPLIGLGTYSDPrpvPGKTYVAVKTAIDEGYRHIDGAYVYHNEHEVGEAIREKIAEGKVKREEIFYCGKLWNTEHVP 112
Cdd:cd19107    1 GAKMPILGLGTWKSP---PGQVTEAVKVAIDAGYRHIDCAYVYQNENEVGEAIQEKIKEQVVKREDLFIVSKLWCTFHEK 77

                         90       100       110
                 ....*....|....*....|....*....|.
gi 568941254 113 SMVLPALERTLKALKLDYIDLYIIELPMAFK 143
Cdd:cd19107   78 GLVKGACQKTLSDLKLDYLDLYLIHWPTGFK 108
AKR_AKR1A1-4 cd19106
AKR1A family of aldo-keto reductase (AKR); The AKR1A family of AKR includes alcohol ...
 30-143 7.94e-48

AKR1A family of aldo-keto reductase (AKR); The AKR1A family of AKR includes alcohol dehydrogenase [NADP(+)] (ALR, EC 1.1.1.2) from Homo sapiens (AKR1A1), Sus scrofa (AKR1A2), Rattus norvegicus (liver, AKR1A3), and Mus musculus (AKR1A4). ALR, also known as aldehyde reductase, or ALDR1, catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. In vitro substrates include succinic semialdehyde, 4-nitrobenzaldehyde, 1,2-naphthoquinone, methylglyoxal, and D-glucuronic acid.


Pssm-ID: 381332 [Multi-domain]  Cd Length: 305  Bit Score: 157.93  E-value: 7.94e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941254  30 LSDGNNIPLIGLGTYsdpRPVPGKTYVAVKTAIDEGYRHIDGAYVYHNEHEVGEAIREKIAEGK-VKREEIFYCGKLWNT 108
Cdd:cd19106    1 LHTGQKMPLIGLGTW---KSKPGQVKAAVKYALDAGYRHIDCAAVYGNEQEVGEALKEKVGPGKaVPREDLFVTSKLWNT 77

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 568941254 109 EHVPSMVLPALERTLKALKLDYIDLYIIELPMAFK 143
Cdd:cd19106   78 KHHPEDVEPALRKTLKDLQLDYLDLYLIHWPYAFE 112
AKR_AKR3G1 cd19123
AKR3G family of aldo-keto reductase (AKR); Synechocystis sp. aldo/keto reductase slr0942 is a ...
 27-143 1.10e-47

AKR3G family of aldo-keto reductase (AKR); Synechocystis sp. aldo/keto reductase slr0942 is a founding member of aldo-keto reductase family 3 member G1 (AKR3G1). It is an aldo/keto reductase that catalyzes the NADPH-dependent reduction of aldehyde- and ketone-groups of different classes of carbonyl compounds to the corresponding alcohols.


Pssm-ID: 381349 [Multi-domain]  Cd Length: 297  Bit Score: 157.19  E-value: 1.10e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941254  27 QISLSDGNNIPLIGLGTYsdpRPVPGKTYVAVKTAIDEGYRHIDGAYVYHNEHEVGEAIREKIAEGKVKREEIFYCGKLW 106
Cdd:cd19123    3 TLPLSNGDLIPALGLGTW---KSKPGEVGQAVKQALEAGYRHIDCAAIYGNEAEIGAALAEVFKEGKVKREDLWITSKLW 79

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 568941254 107 NTEHVPSMVLPALERTLKALKLDYIDLYIIELPMAFK 143
Cdd:cd19123   80 NNSHAPEDVLPALEKTLADLQLDYLDLYLMHWPVALK 116
AKR_AKR1-5-like cd19071
AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins; Aldo-keto reductases ...
 36-150 2.22e-46

AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. The family includes AKR1A/B/C/D/E/G/I, AKR2A/B/C/D/E, AKR3A/B/C/D/E/G, AKR4A/B/C, AKR5A/B/C/D/E/F/G/H, and similar proteins.


Pssm-ID: 381297 [Multi-domain]  Cd Length: 251  Bit Score: 152.25  E-value: 2.22e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941254  36 IPLIGLGTYSDPrpvPGKTYVAVKTAIDEGYRHIDGAYVYHNEHEVGEAIREKIaegkVKREEIFYCGKLWNTEHVPSMV 115
Cdd:cd19071    1 MPLIGLGTYKLK---PEETAEAVLAALEAGYRHIDTAAAYGNEAEVGEAIRESG----VPREELFITTKLWPTDHGYERV 73

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 568941254 116 LPALERTLKALKLDYIDLYIIELPMAFKETTKHRD 150
Cdd:cd19071   74 REALEESLKDLGLDYLDLYLIHWPVPGKEGGSKEA 108
AKR_AKR1G1_CeAKR cd19154
Caenorhabditis elegans aldo-keto reductase (CeAKR) and similar proteins; CeAKR is a founding ...
 28-145 2.67e-45

Caenorhabditis elegans aldo-keto reductase (CeAKR) and similar proteins; CeAKR is a founding member of aldo-keto reductase family 1 member G1 (AKR1G1). It may catalyze the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.


Pssm-ID: 381380 [Multi-domain]  Cd Length: 303  Bit Score: 151.41  E-value: 2.67e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941254  28 ISLSDGNNIPLIGLGTYsDPRPVPGKTyvAVKTAIDEGYRHIDGAYVYHNEHEVGEAIREKIAEGKVKREEIFYCGKLWN 107
Cdd:cd19154    4 ITLSNGVKMPLIGLGTW-QSKGAEGIT--AVRTALKAGYRLIDTAFLYQNEEAIGEALAELLEEGVVKREDLFITTKLWT 80

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 568941254 108 TEHVPSMVLPALERTLKALKLDYIDLYIIELPMAFKET 145
Cdd:cd19154   81 HEHAPEDVEEALRESLKKLQLEYVDLYLIHAPAAFKDD 118
AKR_AKR4C1-15 cd19125
AKR4C family of aldo-keto reductase (AKR); The AKR4C family of AKR includes aldose reductase ...
 30-144 5.25e-45

AKR4C family of aldo-keto reductase (AKR); The AKR4C family of AKR includes aldose reductase (ALR) from Hordeum vulgare (AKR4C1), Bromus inermis (AKR4C2), Avena fatua (AKR4C3), and Xerophyta viscosa (AKR4C4), two aldose reductases, DpAR1 (AKR4C5) and DpAR2(AKR4C6), from Digitalis purpurea, aldehyde reductase from Zea mays (AKR4C7), four aldo-keto reductases from Arabidopsis thaliana (AKR4C8-11), and another three aldo-keto reductases from Aloe arborescens (AKR4C12) and Oryza sativa (AKR4C14/15). ALR (EC 1.1.1.21), also called AR, aldehyde reductase, or polyol dehydrogenase (NADP(+)), is a cytosolic NADPH-dependent oxidoreductase that catalyzes the reduction of a variety of aldehydes and carbonyls, including monosaccharides. Both DpAR1 and DpAR2 reduce the ketone group of steroid structures. They may be involved in plant steroid metabolism in general and in cardenolide biosynthesis in particular. Plant aldo-keto reductases of the AKR4C subfamily play key roles during stress and are attractive targets for developing stress-tolerant crops.


Pssm-ID: 381351 [Multi-domain]  Cd Length: 287  Bit Score: 150.19  E-value: 5.25e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941254  30 LSDGNNIPLIGLGTYsdpRPVPGKTYVAVKTAIDEGYRHIDGAYVYHNEHEVGEAIREKIAEGKVKREEIFYCGKLWNTE 109
Cdd:cd19125    5 LNTGAKIPAVGLGTW---QADPGVVGNAVKTAIKEGYRHIDCAAIYGNEKEIGKALKKLFEDGVVKREDLFITSKLWCTD 81

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 568941254 110 HVPSMVLPALERTLKALKLDYIDLYIIELPMAFKE 144
Cdd:cd19125   82 HAPEDVPPALEKTLKDLQLDYLDLYLIHWPVRLKK 116
AKR_AKR3B1-3 cd19118
AKR3B family of aldo-keto reductase (AKR); Sporidiobolus salmonicolor NADPH-dependent aldehyde ...
 30-146 1.32e-44

AKR3B family of aldo-keto reductase (AKR); Sporidiobolus salmonicolor NADPH-dependent aldehyde reductase 1 (ARI, EC 1.1.1.2), Trichosporonoides megachilieni NADPH-dependent erthyrose reductase (ER) 1/2 and 3, are founding members of aldo-keto reductase family 3 member B1 (AKR3B1), B2 (AKR3B2), and B3 (AKR3B3), respectively. Sporidiobolus salmonicolor NADPH-ARI, also called alcohol dehydrogenase [NADP(+)], or aldehyde reductase I, or ALR 1, catalyzes the asymmetric reduction of aliphatic and aromatic aldehydes and ketones to an R-enantiomer. It reduces ethyl 4-chloro-3-oxobutanoate to ethyl (R)-4-chloro-3-hydroxybutanoate. Trichosporonoides megachilieni NADPH-ERs catalyze the reduction of D-erythrose.


Pssm-ID: 381344 [Multi-domain]  Cd Length: 283  Bit Score: 148.71  E-value: 1.32e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941254  30 LSDGNNIPLIGLGTYsdpRPVPGKTYVAVKTAIDEGYRHIDGAYVYHNEHEVGEAIREKIAE-GKVKREEIFYCGKLWNT 108
Cdd:cd19118    1 LNTGNKIPAIGLGTW---QAEPGEVGAAVKIALKAGYRHLDLAKVYQNQHEVGQALKELLKEePGVKREDLFITSKLWNN 77

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 568941254 109 EHVPSMVLPALERTLKALKLDYIDLYIIELPMAFKETT 146
Cdd:cd19118   78 SHRPEYVEPALDDTLKELGLDYLDLYLIHWPVAFKPTG 115
AKR_AKR1E1-2 cd19110
AKR1E family of aldo-keto reductase (AKR); The AKR1E family of AKR includes 1, ...
 35-143 6.77e-42

AKR1E family of aldo-keto reductase (AKR); The AKR1E family of AKR includes 1,5-anhydro-D-fructose reductase (EC 1.1.1.263) from Mus musculus (liver, AKR1E1) and Homo sapiens (AKR1E2). 1,5-anhydro-D-fructose reductase), also called AF reductase, or aldo-keto reductase family 1 member C-like protein 2 (AKR1CL2), catalyzes the NADPH-dependent reduction of 1,5-anhydro-D-fructose (AF) to 1,5-anhydro-D-glucitol. AKR1E2 is a testis aldo-keto reductase (tAKR), which is also known as testis-specific protein (TSP), or LoopADR.


Pssm-ID: 381336 [Multi-domain]  Cd Length: 301  Bit Score: 142.41  E-value: 6.77e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941254  35 NIPLIGLGTYsdpRPVPGKTYVAVKTAIDEGYRHIDGAYVYHNEHEVGEAIREKIAEGKVKREEIFYCGKLWNTEHVPSM 114
Cdd:cd19110    3 DIPAVGLGTW---KASPGEVTEAVKVAIDAGYRHFDCAYLYHNESEVGAGIREKIKEGVVRREDLFIVSKLWCTCHKKSL 79

                         90       100
                 ....*....|....*....|....*....
gi 568941254 115 VLPALERTLKALKLDYIDLYIIELPMAFK 143
Cdd:cd19110   80 VKTACTRSLKALKLNYLDLYLIHWPMGFK 108
ARA1 COG0656
Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, ...
 32-136 1.48e-38

Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440421 [Multi-domain]  Cd Length: 259  Bit Score: 132.49  E-value: 1.48e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941254  32 DGNNIPLIGLGTYsdpRPVPGKTYVAVKTAIDEGYRHIDGAYVYHNEHEVGEAIRekiaEGKVKREEIFYCGKLWNTEHV 111
Cdd:COG0656    1 NGVEIPALGLGTW---QLPGEEAAAAVRTALEAGYRHIDTAAMYGNEEGVGEAIA----ASGVPREELFVTTKVWNDNHG 73

                         90       100
                 ....*....|....*....|....*
gi 568941254 112 PSMVLPALERTLKALKLDYIDLYII 136
Cdd:COG0656   74 YDDTLAAFEESLERLGLDYLDLYLI 98
AKR_BaDH-like cd19129
Bradyrhizobium diazoefficiens dehydrogenase (DH) and similar proteins; Bradyrhizobium ...
 31-143 2.18e-37

Bradyrhizobium diazoefficiens dehydrogenase (DH) and similar proteins; Bradyrhizobium diazoefficiens DH is the prototype of this family. It belongs to aldo/keto reductase family.


Pssm-ID: 381355 [Multi-domain]  Cd Length: 295  Bit Score: 130.66  E-value: 2.18e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941254  31 SDGNNIPLIGLGTYSdprPVPGKTYVAVKTAIDEGYRHIDGAYVYHNEHEVGEAIREKIAEGKVKREEIFYCGKLWNTEH 110
Cdd:cd19129    1 NGSGAIPALGFGTLI---PDPSATRNAVKAALEAGFRHFDCAERYRNEAEVGEAMQEVFKAGKIRREDLFVTTKLWNTNH 77

                         90       100       110
                 ....*....|....*....|....*....|...
gi 568941254 111 VPSMVLPALERTLKALKLDYIDLYIIELPMAFK 143
Cdd:cd19129   78 RPERVKPAFEASLKRLQLDYLDLYLIHTPFAFQ 110
AKR_AKR1G1_1I cd19111
Caenorhabditis elegans aldo-keto reductase (CeAKR), Coptotermes gestroi aldo-keto reductase ...
 33-142 1.41e-35

Caenorhabditis elegans aldo-keto reductase (CeAKR), Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; CeAKR is a founding member of aldo-keto reductase family 1 member G1 (AKR1G1). It may catalyze the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor. Coptotermes gestroi aldo-keto reductase (CgAKR-1) is a founding member of aldo-keto reductase family 1 member I (AKR1I). It is a multipurpose enzyme with potential biotechnological applications.


Pssm-ID: 381337 [Multi-domain]  Cd Length: 286  Bit Score: 125.69  E-value: 1.41e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941254  33 GNNIPLIGLGTYSDPrpvPGKTYVAVKTAIDEGYRHIDGAYVYHNEHEVGEAIREKIAEGKVKREEIFYCGKLWNTEHVP 112
Cdd:cd19111    1 GFPMPVIGLGTYQSP---PEEVRAAVDYALFVGYRHIDTALSYQNEKAIGEALKWWLKNGKLKREEVFITTKLPPVYLEF 77

                         90       100       110
                 ....*....|....*....|....*....|
gi 568941254 113 SMVLPALERTLKALKLDYIDLYIIELPMAF 142
Cdd:cd19111   78 KDTEKSLEKSLENLKLPYVDLYLIHHPCGF 107
AKR_AKR4A_4B cd19124
AKR4A and AKR4B families of aldo-keto reductase (AKR); The AKR4A family of AKR includes ...
 32-144 2.96e-34

AKR4A and AKR4B families of aldo-keto reductase (AKR); The AKR4A family of AKR includes Glycine max NAD(P)H-dependent 6'-deoxychalcone synthase (6DCS, EC 3.1.170), chalcone reductase (CHR, EC 2.3.1.74) from Medicago sativa, Glycyrrhiza echinate, and Glycyrrhiza glabra, which are founding members of aldo-keto reductase family 4 member A1 (AKR4A1), A2 (AKR4A2), A3 (AKR4A3), and A4 (AKR4A4), respectively. NAD(P)H-6DCS co-acts with chalcone synthase in formation of 4,2',4'-trihydroxychalcone, involved in the biosynthesis of glyceollin type phytoalexins. CHR, also called chalcone polyketide reductase, is a key enzyme of the flavonoid/isoflavonoid biosynthesis pathway. The AKR4B family of AKR includes Sesbania rostrate chalcone reductase (CHR, AKR4B1), Papaver somniferum codeinone reductase (COR, AKR4B2/ AKR4B3), Fragaria x ananassa D-galacturonate reductase (GalUR, AKR4B4), deoxymugineic acid synthase 1 (DMAS1) from Zea mays (AKR4B5), Oryza sativa (AKR4B6), Hordeum vulgare (AKR4B7), Triticum aestivum (AKR4B8), and Erythroxylum coca methylecgonone reductase (MecgoR, AKR4B10). CHR, also called chalcone polyketide reductase, is a key enzyme of the flavonoid/isoflavonoid biosynthesis pathway. NADPH-dependent COR and non-functional NADPH-dependent COR from Papaver somniferum are founding members of aldo-keto reductase family 4 member B2 (AKR4B2) and B3 (AKR4B3), respectively. NADPH-dependent COR (EC 1.1.1.247) reduces codeinone to codeine in the penultimate step in morphine biosynthesis. It can use morphinone, hydrocodone, and hydromorphone as substrates during reductive reaction with NADPH as cofactor, and morphine and dihydrocodeine as substrates during oxidative reaction with NADP as cofactor. GalUR (EC 1.1.1.365), also called aldo-keto reductase 2 (AKR2), is involved in ascorbic acid (vitamin C) biosynthesis by catalyzing the conversion from L-galactonate and NADP(+) to D-galacturonate and NADPH. DMAS1 (EC 1.1.1.285) catalyzes the reduction of a 3''-keto intermediate during the biosynthesis of 2'-deoxymugineic acid (DMA) from L-Met. It is involved in the formation of phytosiderophores (MAs) belonging to the mugineic acid family and required to acquire iron. MecgoR catalyzes the stereospecific reduction of methylecgonone to methylecgonine, the penultimate step in cocaine biosynthesis.


Pssm-ID: 381350 [Multi-domain]  Cd Length: 281  Bit Score: 121.99  E-value: 2.96e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941254  32 DGNNIPLIGLGTYSDPrPVPGKTYVAVKTAIDEGYRHIDGAYVYHNEHEVGEAIREKIAEGKVK-REEIFYCGKLWNTEH 110
Cdd:cd19124    1 SGQTMPVIGMGTASDP-PSPEDIKAAVLEAIEVGYRHFDTAAAYGTEEALGEALAEALRLGLVKsRDELFVTSKLWCSDA 79

                         90       100       110
                 ....*....|....*....|....*....|....
gi 568941254 111 VPSMVLPALERTLKALKLDYIDLYIIELPMAFKE 144
Cdd:cd19124   80 HPDLVLPALKKSLRNLQLEYVDLYLIHWPVSLKP 113
AKR_AKR3D1 cd19121
AKR3D family of aldo-keto reductase (AKR); Trichoderma reesei D-galacturonate reductase (GAR1, ...
 30-148 6.35e-34

AKR3D family of aldo-keto reductase (AKR); Trichoderma reesei D-galacturonate reductase (GAR1, EC 1.1.1.365), also called D-galacturonic acid reductase, or GalUR, is a founding member of aldo-keto reductase family 3 member D1 (AKR3D1). It mediates the reduction of D-galacturonate to L-galactonate, the first step in D-galacturonate catabolic process. It also has activity with D-glucuronate and DL-glyceraldehyde. Its activity is seen only with NADPH and not with NADH.


Pssm-ID: 381347 [Multi-domain]  Cd Length: 279  Bit Score: 121.10  E-value: 6.35e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941254  30 LSDGNNIPLIGLGTYSDPrpvPGKTYVAVKTAIDEGYRHIDGAYVYHNEHEVGEAIREKIAEGkVKREEIFYCGKLWNTE 109
Cdd:cd19121    6 LNTGASIPAVGLGTWQAK---AGEVKAAVAHALKIGYRHIDGALCYQNEDEVGEGIKEAIAGG-VKREDLFVTTKLWSTY 81

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 568941254 110 HvpSMVLPALERTLKALKLDYIDLYIIELPMAFKETTKH 148
Cdd:cd19121   82 H--RRVELCLDRSLKSLGLDYVDLYLVHWPVLLNPNGNH 118
AKR_AKR2B1-10 cd19113
AKR2B family of aldo-keto reductase (AKR); The AKR2B family of AKR includes NAD(P)H-dependent ...
 28-143 1.61e-33

AKR2B family of aldo-keto reductase (AKR); The AKR2B family of AKR includes NAD(P)H-dependent D-xylose reductase (XR) from Pichia stipites, Kluyveromyces lactis, Pachysolen tannophilus, Candida tropicalis, and Candida tenuis, Gre3p from Saccharomyces cerevisiae, XR from Candida tropicalis, Pichia guilliermondii, Debaryomyces hansenli, and Debaryomyces nepalensis, which correspond to aldo-keto reductase family 2 member B1-B10 (AKR2B1-10), respectively. XR (EC1.1.1.307) catalyzes the NAD(P)H dependent reduction of xylose to xylitol.


Pssm-ID: 381339 [Multi-domain]  Cd Length: 310  Bit Score: 121.01  E-value: 1.61e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941254  28 ISLSDGNNIPLIGLGTYSDPRPVPGKTyvaVKTAIDEGYRHIDGAYVYHNEHEVGEAIREKIAEGKVKREEIFYCGKLWN 107
Cdd:cd19113    3 IKLNSGYKMPSVGFGCWKLDNATAADQ---IYQAIKAGYRLFDGAEDYGNEKEVGEGVNRAIDEGLVKREELFLTSKLWN 79

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 568941254 108 TEHVPSMVLPALERTLKALKLDYIDLYIIELPMAFK 143
Cdd:cd19113   80 NFHDPKNVETALNKTLSDLKLDYVDLFLIHFPIAFK 115
AKR_AKR3E1 cd19122
AKR3E family of aldo-keto reductase (AKR); Trichoderma reesei NADP(+)-dependent glycerol ...
 29-167 1.27e-32

AKR3E family of aldo-keto reductase (AKR); Trichoderma reesei NADP(+)-dependent glycerol 2-dehydrogenase (GLD2, EC 1.1.1.156), also called dihydroxyacetone reductase, is a founding member of aldo-keto reductase family 3 member E1 (AKR3E1). It acts as a glycerol oxidoreductase probably involved in glycerol synthesis.


Pssm-ID: 381348 [Multi-domain]  Cd Length: 291  Bit Score: 118.11  E-value: 1.27e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941254  29 SLSDGNNIPLIGLGTYSDpRPVPGKTYVAVKTAIDEGYRHIDGAYVYHNEHEVGEAIREKIAEG-KVKREEIFYCGKLWN 107
Cdd:cd19122    2 TLNNGVKIPAVGFGTFAN-EGAKGETYAAVTKALDVGYRHLDCAWFYLNEDEVGDAVRDFLKENpSVKREDLFICTKVWN 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941254 108 TEHVPSMVLPALERTLKALKLDYIDLYIIELPMAFKETTKHRDQIcdaktkaeSEDGIYL 167
Cdd:cd19122   81 HLHEPEDVKWSIDNSLKNLKLDYIDLFLVHWPIAAEKNDQRSPKL--------GPDGKYV 132
AKR_AKR2A1-2 cd19112
AKR2A family of aldo-keto reductase (AKR); The AKR2A family of AKR includes AKR2A1 ...
 28-145 1.99e-32

AKR2A family of aldo-keto reductase (AKR); The AKR2A family of AKR includes AKR2A1 (NADP-dependent D-sorbitol-6-phosphate dehydrogenase or NADP-S6PDH) from Malus domestica, and AKR2A2 (NADPH-dependent mannose-6-phosphate reductase or NADPH-M6PR) from Apium graveolens. NADP-S6PDH (EC 1.1.1.200), also called aldose-6-phosphate reductase [NADPH], synthesizes sorbitol-6-phosphate, a key intermediate in the synthesis of sorbitol which is a major photosynthetic product in many members of the Rosaceae family. NADPH-M6PR (EC 1.1.1.224), also called NADPH-dependent M6P reductase, is a key enzyme involved in mannitol biosynthesis.


Pssm-ID: 381338 [Multi-domain]  Cd Length: 308  Bit Score: 117.97  E-value: 1.99e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941254  28 ISLSDGNNIPLIGLGTYsdpRPVPGKTYVAVKTAIDEGYRHIDGAYVYHNEHEVGEAIREKIAEGKVKREEIFYCGKLWN 107
Cdd:cd19112    3 ITLNSGHKMPVIGLGVW---RMEPGEIKELILNAIKIGYRHFDCAADYKNEKEVGEALAEAFKTGLVKREDLFITTKLWN 79

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 568941254 108 TEHvpSMVLPALERTLKALKLDYIDLYIIELPMAFKET 145
Cdd:cd19112   80 SDH--GHVIEACKDSLKKLQLDYLDLYLVHFPVATKHT 115
AKR_AKR3C1 cd19119
Saccharomyces cerevisiae D-arabinose dehydrogenase [NAD(P)+] heavy chain (Ara1p) and similar ...
 28-143 1.24e-31

Saccharomyces cerevisiae D-arabinose dehydrogenase [NAD(P)+] heavy chain (Ara1p) and similar proteins; Saccharomyces cerevisiae Ara1p (EC 1.1.1.117), also called D-arabinose 1-dehydrogenase (NAD(P)(+)), is a founding members of aldo-keto reductase family 3 member C1 (AKR3C1). It catalyzes the oxidation of D-arabinose, L-xylose, L-fucose, and L-galactose in the presence of NADP(+).


Pssm-ID: 381345 [Multi-domain]  Cd Length: 294  Bit Score: 115.67  E-value: 1.24e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941254  28 ISLSDGNNIPLIGLGTYSdPRPVPGKTYVAVKTAIDEGYRHIDGAYVYHNEHEVGEAIREKIAEGKVKREEIFYCGKLWN 107
Cdd:cd19119    4 FKLNTGASIPALGLGTAS-PHEDRAEVKEAVEAAIKEGYRHIDTAYAYETEDFVGEAIKRAIDDGSIKREELFITTKVWP 82

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 568941254 108 TEHvpSMVLPALERTLKALKLDYIDLYIIELPMAFK 143
Cdd:cd19119   83 TFY--DEVERSLDESLKALGLDYVDLLLVHWPVCFE 116
AKR_AKR5C2 cd19131
Escherichia coli 2,5-diketo-D-gluconic acid reductase A (DkgA/YqhE) and similar proteins; ...
 27-140 1.30e-31

Escherichia coli 2,5-diketo-D-gluconic acid reductase A (DkgA/YqhE) and similar proteins; Escherichia coli DkgA/YqhE is a founding member of aldo-keto reductase family 5 member C2 (AKR5C2). DkgA/YqhE (EC 1.1.1.274), also called 2,5-DKG reductase A, or 2,5-DKGR A, or 25DKGR-A, or AKR5C, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). It is also capable of stereoselective -keto ester reductions on ethyl acetoacetate and other 2-substituted derivatives.


Pssm-ID: 381357 [Multi-domain]  Cd Length: 256  Bit Score: 114.39  E-value: 1.30e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941254  27 QISLSDGNNIPLIGLGTYSDPrpvPGKTYVAVKTAIDEGYRHIDGAYVYHNEHEVGEAIREkiaeGKVKREEIFYCGKLW 106
Cdd:cd19131    1 TITLNDGNTIPQLGLGVWQVS---NDEAASAVREALEVGYRSIDTAAIYGNEEGVGKAIRA----SGVPREELFITTKLW 73

                         90       100       110
                 ....*....|....*....|....*....|....
gi 568941254 107 NTEHVPSMVLPALERTLKALKLDYIDLYIIELPM 140
Cdd:cd19131   74 NSDQGYDSTLRAFDESLRKLGLDYVDLYLIHWPV 107
AKR_AKR3A1-2 cd19117
AKR3A family of aldo-keto reductase (AKR); Saccharomyces cerevisiae Gcy1p and Ypr1p are ...
 29-169 2.41e-31

AKR3A family of aldo-keto reductase (AKR); Saccharomyces cerevisiae Gcy1p and Ypr1p are founding members of aldo-keto reductase family 3 member A1 (AKR3A1) and A2 (AKR3A2), respectively. Gcy1p, also called galactose-inducible crystallin-like protein 1, is a glycerol dehydrogenase involved in glycerol catabolism under microaerobic conditions. It has mRNA binding activity. Ypr1p acts as a 2-methylbutyraldehyde reductase that displays high specific activity towards 2-methylbutyraldehyde, as well as other aldehydes such as hexanal.


Pssm-ID: 381343 [Multi-domain]  Cd Length: 284  Bit Score: 114.52  E-value: 2.41e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941254  29 SLSDGNNIPLIGLGTYsdpRPVPGKTYVAVKTAIDEGYRHIDGAYVYHNEHEVGEAIRekiAEGkVKREEIFYCGKLWNT 108
Cdd:cd19117    7 KLNTGAEIPAVGLGTW---QSKPNEVAKAVEAALKAGYRHIDTAAIYGNEEEVGQGIK---DSG-VPREEIFITTKLWCT 79

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568941254 109 EHvpSMVLPALERTLKALKLDYIDLYIIELPMAFKETTKHRDQICDAKTKAESEDgiylWN 169
Cdd:cd19117   80 WH--RRVEEALDQSLKKLGLDYVDLYLMHWPVPLDPDGNDFLFKKDDGTKDHEPD----WD 134
AKR_AKR2C1 cd19114
AKR2C family of aldo-keto reductase (AKR); Mucor mucedo NADP-dependent ...
 33-143 3.50e-31

AKR2C family of aldo-keto reductase (AKR); Mucor mucedo NADP-dependent 4-dihydromethyl-trisporate dehydrogenase (TDH), also called 4-dihydromethyltrisporate dehydrogenase, or 4-dihydromethyl-TA dehydrogenase, is a founding member of aldo-keto reductase family 2 member C1 (AKR2C1). It is involved in the biosynthesis of trisporic acid, the sexual hormone of zygomycetes, which induces the first steps of zygophore development. TDH catalyzes the NADP-dependent oxidation of (+) mating-type specific precursor 4-dihydromethyl-trisporate to methyl-trisporate.


Pssm-ID: 381340 [Multi-domain]  Cd Length: 302  Bit Score: 114.58  E-value: 3.50e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941254  33 GNNIPLIGLGTYsdpRPVPGKTYVAVKTAIDEGYRHIDGAYVYHNEHEVGEAIREKIAEGKVKREEIFYCGKLWNTEHVP 112
Cdd:cd19114    1 GDKMPLVGFGTA---KIKANETEEVIYNAIKVGYRLIDGALLYGNEAEVGRGIRKAIQEGLVKREDLFIVTKLWNNFHGK 77

                         90       100       110
                 ....*....|....*....|....*....|.
gi 568941254 113 SMVLPALERTLKALKLDYIDLYIIELPMAFK 143
Cdd:cd19114   78 DHVREAFDRQLKDYGLDYIDLYLIHFPIPAA 108
AKR_AKR1I_CgAKR1 cd19155
Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; Coptotermes gestroi ...
 28-184 2.78e-30

Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; Coptotermes gestroi aldo-keto reductase (CgAKR-1) is a founding member of aldo-keto reductase family 1 member I (AKR1I). It is a multipurpose enzyme with potential biotechnological applications.


Pssm-ID: 381381 [Multi-domain]  Cd Length: 307  Bit Score: 112.23  E-value: 2.78e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941254  28 ISLSDGNNIPLIGLGTYSDPrpvPGKTYVAVKTAIDEGYRHIDGAYVYHNEHEVGEAIREKIAEGKVKREEIFYCGKLWN 107
Cdd:cd19155    4 VTFNNGEKMPVVGLGTWQSS---PEEIETAVDTALEAGYRHIDTAYVYRNEAAIGNVLKKWIDSGKVKREELFIVTKLPP 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568941254 108 TEHVPSMVLPALERTLKALKLDYIDLYIIELPMAFkettkhrdQICDAKTKAESEDGIYLWNSSTVLLALFPSIDTL 184
Cdd:cd19155   81 GGNRREKVEKFLLKSLEKLQLDYVDLYLIHFPVGS--------LSKEDDSGKLDPTGEHKQDYTTDLLDIWKAMEAQ 149
AKR_AKR5F1 cd19133
the AKR5F family of aldo-keto reductase (AKR); Klebsiella sp. 2,5-diketo-D-gluconic acid ...
 28-140 3.32e-30

the AKR5F family of aldo-keto reductase (AKR); Klebsiella sp. 2,5-diketo-D-gluconic acid reductase (2,5-DKG reductase) is a founding member of aldo-keto reductase family 5 member F1 (AKR5F1). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).


Pssm-ID: 381359 [Multi-domain]  Cd Length: 255  Bit Score: 110.74  E-value: 3.32e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941254  28 ISLSDGNNIPLIGLGTYSdpRPVPGKTYVAVKTAIDEGYRHIDGAYVYHNEHEVGEAIREKiaegKVKREEIFYCGKLW- 106
Cdd:cd19133    1 VTLNNGVEMPILGFGVFQ--IPDPEECERAVLEAIKAGYRLIDTAAAYGNEEAVGRAIKKS----GIPREELFITTKLWi 74

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 568941254 107 -NTEHVPSMvlPALERTLKALKLDYIDLYIIELPM 140
Cdd:cd19133   75 qDAGYEKAK--KAFERSLKRLGLDYLDLYLIHQPF 107
AKR_GlAR-like cd19128
Giardia lamblia aldose reductase (AR) and similar proteins; Giardia lamblia AR (EC 1.1.1.21), ...
 37-142 1.05e-29

Giardia lamblia aldose reductase (AR) and similar proteins; Giardia lamblia AR (EC 1.1.1.21), also called aldehyde reductase, is the prototype of this family. It catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.


Pssm-ID: 381354 [Multi-domain]  Cd Length: 277  Bit Score: 110.31  E-value: 1.05e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941254  37 PLIGLGTYSDPrpvPGKTYVAVKTAIDEGYRHIDGAYVYHNEHEVGEAIREKIAEGKVKREEIFYCGKLWNTEHVPSMVL 116
Cdd:cd19128    2 PRLGFGTYKIT---ESESKEAVKNAIKAGYRHIDCAYYYGNEAFIGIAFSEIFKDGGVKREDLFITSKLWPTMHQPENVK 78

                         90       100
                 ....*....|....*....|....*.
gi 568941254 117 PALERTLKALKLDYIDLYIIELPMAF 142
Cdd:cd19128   79 EQLLITLQDLQLEYLDLFLIHWPLAF 104
AKR_AKR3F3 cd19140
Sinorhizobium meliloti isatin reductase and similar proteins; Sinorhizobium meliloti isatin ...
 33-145 1.70e-29

Sinorhizobium meliloti isatin reductase and similar proteins; Sinorhizobium meliloti isatin reductase is a founding member of aldo-keto reductase family 3 member F3 (AKR3F3). It is a aldo/keto reductase family oxidoreductase.


Pssm-ID: 381366 [Multi-domain]  Cd Length: 253  Bit Score: 108.89  E-value: 1.70e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941254  33 GNNIPLIGLGTYsdpRPVPGKTYVAVKTAIDEGYRHIDGAYVYHNEHEVGEAirekIAEGKVKREEIFYCGKLWNTEHVP 112
Cdd:cd19140    5 GVRIPALGLGTY---PLTGEECTRAVEHALELGYRHIDTAQMYGNEAQVGEA----IAASGVPRDELFLTTKVWPDNYSP 77

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 568941254 113 SMVLPALERTLKALKLDYIDLYIIELP---MAFKET 145
Cdd:cd19140   78 DDFLASVEESLRKLRTDYVDLLLLHWPnkdVPLAET 113
AKR_AKR5A1_2 cd19156
AKR5A family of aldo-keto reductase (AKR); Prostaglandin F2-alpha synthase (PGFS) from ...
 28-159 1.45e-28

AKR5A family of aldo-keto reductase (AKR); Prostaglandin F2-alpha synthase (PGFS) from Leishmania major and Trypanosoma brucei are founding members of aldo-keto reductase family 5 member A1 (AKR5A1) and A2 (AKR5A2), respectively. PGFS, also called 9,11-endoperoxide prostaglandin H2 reductase, catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. It has also aldo/ketoreductase activity toward the synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde.


Pssm-ID: 381382 [Multi-domain]  Cd Length: 266  Bit Score: 106.83  E-value: 1.45e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941254  28 ISLSDGNNIPLIGLGTYSDPRPvpGKTYVAVKTAIDEGYRHIDGAYVYHNEHEVGEAIREKiaegKVKREEIFYCGKLWN 107
Cdd:cd19156    1 VKLANGVEMPRLGLGVWRVQDG--AEAENAVKWAIEAGYRHIDTAAIYKNEEGVGQGIRES----GVPREEVFVTTKLWN 74

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 568941254 108 TEHVPSMVLPALERTLKALKLDYIDLYIIELPMA--FKETTKHRDQI-CDAKTKA 159
Cdd:cd19156   75 SDQGYESTLAAFEESLEKLGLDYVDLYLIHWPVKgkFKDTWKAFEKLyKEKKVRA 129
AKR_AKR5A_5G cd19126
AKR5A and AKR5G families of aldo-keto reductase (AKR); The AKR5A family of AKR includes ...
 28-159 1.81e-28

AKR5A and AKR5G families of aldo-keto reductase (AKR); The AKR5A family of AKR includes prostaglandin F2-alpha synthase (PGFS) from Leishmania major (AKR5A1) and Trypanosoma brucei (AKR5A2). PGFS, also called 9,11-endoperoxide prostaglandin H2 reductase, catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. It has also aldo/ketoreductase activity for synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde. The AKR5G family of AKR includes Bacillus subtilis glyoxal reductase (GR), uncharacterized oxidoreductase YtbE, and Bacillus aryabhattai aldo-keto reductase, which corresponds to aldo-keto reductase family 5 member G1-3 (AKR5G1-3), respectively. GR (YvgN, EC 1.1.1.283), also called methylglyoxal reductase, reduces glyoxal and methylglyoxal (2-oxopropanal). It is not involved in vitamin B6 biosynthesis.


Pssm-ID: 381352 [Multi-domain]  Cd Length: 254  Bit Score: 106.37  E-value: 1.81e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941254  28 ISLSDGNNIPLIGLGTYSDPRPvpGKTYVAVKTAIDEGYRHIDGAYVYHNEHEVGEAIREkiaeGKVKREEIFYCGKLWN 107
Cdd:cd19126    1 VTLNNGTRMPWLGLGVFQTPDG--DETERAVQTALENGYRSIDTAAIYKNEEGVGEAIRE----SGVPREELFVTTKLWN 74

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 568941254 108 TEHVPSMVLPALERTLKALKLDYIDLYIIELPMA--FKETTKHRDQI-CDAKTKA 159
Cdd:cd19126   75 DDQRARRTEDAFQESLDRLGLDYVDLYLIHWPGKdkFIDTWKALEKLyASGKVKA 129
AKR_AKR5B1 cd19127
AKR5B family of aldo-keto reductase (AKR); Pseudomonas putida morphine 6-dehydrogenase (M6DH) ...
 28-141 2.32e-28

AKR5B family of aldo-keto reductase (AKR); Pseudomonas putida morphine 6-dehydrogenase (M6DH) is a founding member of the aldo-keto reductase family 5 member B1 (AKR5B1). M6DH (EC 1.1.1.218), also called naloxone reductase, oxidizes the C-6 hydroxy group of morphine and codeine.


Pssm-ID: 381353 [Multi-domain]  Cd Length: 268  Bit Score: 106.34  E-value: 2.32e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941254  28 ISLSDGNNIPLIGLGTYSDPrpvPGKTYVAVKTAIDEGYRHIDGAYVYHNEHEVGEAIREKiaegKVKREEIFYCGKLWN 107
Cdd:cd19127    1 ITLNNGVEMPALGLGVFQTP---PEETADAVATALADGYRLIDTAAAYGNEREVGEGIRRS----GVDRSDIFVTTKLWI 73

                         90       100       110
                 ....*....|....*....|....*....|....
gi 568941254 108 TEHVPSMVLPALERTLKALKLDYIDLYIIELPMA 141
Cdd:cd19127   74 SDYGYDKALRGFDASLRRLGLDYVDLYLLHWPVP 107
AKR_AKR5G1-3 cd19157
AKR5G family of aldo-keto reductase (AKR); Bacillus subtilis glyoxal reductase (GR), ...
 28-147 2.97e-28

AKR5G family of aldo-keto reductase (AKR); Bacillus subtilis glyoxal reductase (GR), uncharacterized oxidoreductase YtbE, and Bacillus aryabhattai aldo-keto reductase are founding members of aldo-keto reductase family 5 member G1-3 (AKR5G1-3), respectively. GR (YvgN, EC 1.1.1.283), also called methylglyoxal reductase, reduces glyoxal and methylglyoxal (2-oxopropanal). It is not involved in vitamin B6 biosynthesis.


Pssm-ID: 381383 [Multi-domain]  Cd Length: 265  Bit Score: 105.94  E-value: 2.97e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941254  28 ISLSDGNNIPLIGLGTYSDPRpvpGKTYV-AVKTAIDEGYRHIDGAYVYHNEHEVGEAIREkiaeGKVKREEIFYCGKLW 106
Cdd:cd19157    2 VTLNNGVKMPWLGLGVFKVEE---GSEVVnAVKTALKNGYRSIDTAAIYGNEEGVGKGIKE----SGIPREELFITSKVW 74

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 568941254 107 NTEHVPSMVLPALERTLKALKLDYIDLYIIELPMA--FKETTK 147
Cdd:cd19157   75 NADQGYDSTLKAFEASLERLGLDYLDLYLIHWPVKgkYKETWK 117
AKR_AKR5D1_E1 cd19132
AKR5D and AKR5E families of aldo-keto reductase (AKR); 2,5-diketo-D-gluconic acid reductase B ...
 30-139 2.03e-27

AKR5D and AKR5E families of aldo-keto reductase (AKR); 2,5-diketo-D-gluconic acid reductase B (DkgB) from Corynebacterium sp. and 2,5-diketo-D-gluconic acid reductase Zymomonas mobilis are founding members of aldo-keto reductase family 5 member D1 (AKR5D1) and E1 (AKR5E1), respectively. DkgB (EC 1.1.1.274), also called 2,5-didehydrogluconate reductase (2-dehydro-D-gluconate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).


Pssm-ID: 381358 [Multi-domain]  Cd Length: 255  Bit Score: 103.50  E-value: 2.03e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941254  30 LSDGNNIPLIGLGTYsdprPVPGKTYV-AVKTAIDEGYRHIDGAYVYHNEHEVGEAIREkiaeGKVKREEIFYCGKLWNT 108
Cdd:cd19132    1 LNDGTQIPAIGFGTY----PLKGDEGVeAVVAALQAGYRLLDTAFNYENEGAVGEAVRR----SGVPREELFVTTKLPGR 72

                         90       100       110
                 ....*....|....*....|....*....|.
gi 568941254 109 EHVPSMVLPALERTLKALKLDYIDLYIIELP 139
Cdd:cd19132   73 HHGYEEALRTIEESLYRLGLDYVDLYLIHWP 103
AKR_AKR2D1 cd19115
AKR2D family of aldo-keto reductase (AKR); Aspergillus niger NAD(P)H-dependent D-xylose ...
 27-143 3.98e-27

AKR2D family of aldo-keto reductase (AKR); Aspergillus niger NAD(P)H-dependent D-xylose reductase xyl1 (XR, EC 1.1.1.307) is a founding member of aldo-keto reductase family 2 member D1 (AKR2D1). It catalyzes the initial reaction in the xylose utilization pathway by reducing D-xylose into xylitol in a NAD(P)H dependent manner.


Pssm-ID: 381341 [Multi-domain]  Cd Length: 311  Bit Score: 104.04  E-value: 3.98e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941254  27 QISLSDGNNIPLIGLGTYSDPRPVPGKTyvaVKTAIDEGYRHIDGAYVYHNEHEVGEAIREKIAEGKVKREEIFYCGKLW 106
Cdd:cd19115    4 TVKLNSGYDMPLVGFGLWKVNNDTCADQ---VYNAIKAGYRLFDGACDYGNEVEAGQGVARAIKEGIVKREDLFIVSKLW 80

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 568941254 107 NTEHVPSMVLPALERTLKALKLDYIDLYIIELPMAFK 143
Cdd:cd19115   81 NTFHDGERVEPICRKQLADWGIDYFDLFLIHFPIALK 117
AKR_AKR5C1 cd19130
Corynebacterium sp. 2,5-diketo-D-gluconic acid reductase A (DkgA) and similar proteins; ...
 27-140 9.25e-27

Corynebacterium sp. 2,5-diketo-D-gluconic acid reductase A (DkgA) and similar proteins; Corynebacterium sp. DkgA is a founding member of aldo-keto reductase family 5 member C1 (AKR5C1). DkgA (EC 1.1.1.346), also called 2,5-DKG reductase A, or 2,5-DKGR A, or 25DKGR-A, or AKR5C, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). 5-keto-D-fructose and dihydroxyacetone can also serve as substrates.


Pssm-ID: 381356 [Multi-domain]  Cd Length: 256  Bit Score: 101.91  E-value: 9.25e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941254  27 QISLSDGNNIPLIGLGTYSDPrpvPGKTYVAVKTAIDEGYRHIDGAYVYHNEHEVGEAIrekiAEGKVKREEIFYCGKLW 106
Cdd:cd19130    1 SIVLNDGNSIPQLGYGVFKVP---PADTQRAVATALEVGYRHIDTAAIYGNEEGVGAAI----AASGIPRDELFVTTKLW 73

                         90       100       110
                 ....*....|....*....|....*....|....
gi 568941254 107 NTEHVPSMVLPALERTLKALKLDYIDLYIIELPM 140
Cdd:cd19130   74 NDRHDGDEPAAAFAESLAKLGLDQVDLYLVHWPT 107
dkgA PRK11565
2,5-didehydrogluconate reductase DkgA;
28-145 7.14e-26

2,5-didehydrogluconate reductase DkgA;


Pssm-ID: 183203 [Multi-domain]  Cd Length: 275  Bit Score: 100.15  E-value: 7.14e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941254  28 ISLSDGNNIPLIGLGTY--SDPRPVpgktyVAVKTAIDEGYRHIDGAYVYHNEHEVGEAIRekiaEGKVKREEIFYCGKL 105
Cdd:PRK11565   7 IKLQDGNVMPQLGLGVWqaSNEEVI-----TAIHKALEVGYRSIDTAAIYKNEEGVGKALK----EASVAREELFITTKL 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 568941254 106 WNTEHvpSMVLPALERTLKALKLDYIDLYIIELPMAFKET 145
Cdd:PRK11565  78 WNDDH--KRPREALEESLKKLQLDYVDLYLMHWPVPAIDH 115
AKR_AKR3F2_3 cd19073
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB), Sinorhizobium meliloti ...
 36-139 8.68e-26

Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB), Sinorhizobium meliloti isatin reductase and similar proteins; Escherichia coli DkgB/YafB (EC 1.1.1.346), also called 2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, is a founding member of aldo-keto reductase family 3 member F2 (AKR3F2). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). Sinorhizobium meliloti isatin reductase is a founding member of aldo-keto reductase family 3 member F3 (AKR3F3). It is a aldo/keto reductase family oxidoreductase.


Pssm-ID: 381299 [Multi-domain]  Cd Length: 243  Bit Score: 98.88  E-value: 8.68e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941254  36 IPLIGLGTYsdpRPVPGKTYVAVKTAIDEGYRHIDGAYVYHNEHEVGEAIrekiAEGKVKREEIFYCGKLWNTEHVPSMV 115
Cdd:cd19073    1 IPALGLGTW---QLRGDDCANAVKEALELGYRHIDTAEIYNNEAEVGEAI----AESGVPREDLFITTKVWRDHLRPEDL 73

                         90       100
                 ....*....|....*....|....
gi 568941254 116 LPALERTLKALKLDYIDLYIIELP 139
Cdd:cd19073   74 KKSVDRSLEKLGTDYVDLLLIHWP 97
AKR_DrGR-like cd19136
Danio rerio glyoxal reductase-like (GR-like) protein and similar proteins; Danio rerio GR-like ...
 36-139 1.22e-24

Danio rerio glyoxal reductase-like (GR-like) protein and similar proteins; Danio rerio GR-like protein is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase similar to Bacillus subtilis glyoxal reductase (YvgN) that reduces glyoxal and methylglyoxal (2-oxopropanal).


Pssm-ID: 381362 [Multi-domain]  Cd Length: 262  Bit Score: 96.55  E-value: 1.22e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941254  36 IPLIGLGTYSdprpVPGK--TYVAVKTAIDEGYRHIDGAYVYHNEHEVGEAIREKIAEGKVKREEIFYCGKLWNTEHVPS 113
Cdd:cd19136    1 MPILGLGTFR----LRGEeeVRQAVDAALKAGYRLIDTASVYRNEADIGKALRDLLPKYGLSREDIFITSKLAPKDQGYE 76

                         90       100
                 ....*....|....*....|....*.
gi 568941254 114 MVLPALERTLKALKLDYIDLYIIELP 139
Cdd:cd19136   77 KARAACLGSLERLGTDYLDLYLIHWP 102
AKR_AKR3C2-3 cd19120
Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase, Candida parapsilosis ...
 33-147 2.74e-24

Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase, Candida parapsilosis NADPH-dependent conjugated polyketone reductase C2 (CPR), and similar proteins; Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase (EC 1.1.1.190/EC 1.1.1.191) and Candida parapsilosis NADPH-dependent CPR (EC 1.1.1.358/EC 1.1.1.168) are founding members of aldo-keto reductase family 3 member C2 (AKR3C2) and C3 (AKR3C3), respectively. Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase catalyzes the conversion from (Indol-3-yl)ethanol to (indol-3-yl)acetaldehyde in a NAD/NADP-dependent manner. CPR, also called 2-dehydropantolactone reductase, or 2-dehydropantolactone reductase (A-specific), or ketopantoyl-lactone reductase, acts as a NADPH-dependent conjugated polyketone reductase with broad substrate specificity and strict stereospecificity. It reduces ketopantoyl lactone and isatin.


Pssm-ID: 381346 [Multi-domain]  Cd Length: 269  Bit Score: 95.76  E-value: 2.74e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941254  33 GNNIPLIGLGT----YSDPRPVPGKTYV-AVKTAIDEGYRHIDGAYVYHNEHEVGEAIREKiaegKVKREEIFYCGKLW- 106
Cdd:cd19120    1 GSKIPAIAFGTgtawYKSGDDDIQRDLVdSVKLALKAGFRHIDTAEMYGNEKEVGEALKES----GVPREDLFITTKVSp 76

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 568941254 107 NTEHVPSmvlpALERTLKALKLDYIDLYIIELPMAFKETTK 147
Cdd:cd19120   77 GIKDPRE----ALRKSLAKLGVDYVDLYLIHSPFFAKEGGP 113
AKR_AKR3F2 cd19139
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB) and similar proteins; ...
 36-139 1.02e-23

Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB) and similar proteins; Escherichia coli DkgB/YafB (EC 1.1.1.346), also called 2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, is a founding member of aldo-keto reductase family 3 member F2 (AKR3F2). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).


Pssm-ID: 381365 [Multi-domain]  Cd Length: 248  Bit Score: 93.57  E-value: 1.02e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941254  36 IPLIGLGTYsdpRPVPGKTYVAVKTAIDEGYRHIDGAYVYHNEHEVGEAirekIAEGKVKREEIFYCGKLWNTEHVPSMV 115
Cdd:cd19139    1 IPAFGLGTF---RLKDDVVIDSVRTALELGYRHIDTAQIYDNEAAVGQA----IAESGVPRDELFITTKIWIDNLSKDKL 73

                         90       100
                 ....*....|....*....|....
gi 568941254 116 LPALERTLKALKLDYIDLYIIELP 139
Cdd:cd19139   74 LPSLEESLEKLRTDYVDLTLIHWP 97
dkgB PRK11172
2,5-didehydrogluconate reductase DkgB;
35-139 5.48e-22

2,5-didehydrogluconate reductase DkgB;


Pssm-ID: 183012 [Multi-domain]  Cd Length: 267  Bit Score: 89.70  E-value: 5.48e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941254  35 NIPLIGLGTYSdprpVPGKTYVA-VKTAIDEGYRHIDGAYVYHNEHEVGEAirekIAEGKVKREEIFYCGKLWNTEHVPS 113
Cdd:PRK11172   2 SIPAFGLGTFR----LKDQVVIDsVKTALELGYRAIDTAQIYDNEAAVGQA----IAESGVPRDELFITTKIWIDNLAKD 73

                         90       100
                 ....*....|....*....|....*.
gi 568941254 114 MVLPALERTLKALKLDYIDLYIIELP 139
Cdd:PRK11172  74 KLIPSLKESLQKLRTDYVDLTLIHWP 99
AKR_CeZK1290-like cd19135
Caenorhabditis elegans ZK1290.5 and similar proteins; Caenorhabditis elegans ZK1290.5 is the ...
 30-139 3.10e-21

Caenorhabditis elegans ZK1290.5 and similar proteins; Caenorhabditis elegans ZK1290.5 is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase.


Pssm-ID: 381361 [Multi-domain]  Cd Length: 265  Bit Score: 87.38  E-value: 3.10e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941254  30 LSDGNNIPLIGLGT-----YSDPrpvpgktyvAVKTAIDE-GYRHIDGAYVYHNEHEVGEAIREkiaeGKVKREEIFYCG 103
Cdd:cd19135    7 LSNGVEMPILGLGTshsggYSHE---------AVVYALKEcGYRHIDTAKRYGCEELLGKAIKE----SGVPREDLFLTT 73

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 568941254 104 KLWNTEHVPSMVLPALERTLKALKLDYIDLYIIELP 139
Cdd:cd19135   74 KLWPSDYGYESTKQAFEASLKRLGVDYLDLYLLHWP 109
AKR_AKR5H1 cd19134
AKR5H family of aldo-keto reductase (AKR); Mycobacterium smegmatis MSMEG_2407 is a founding ...
 28-141 1.25e-20

AKR5H family of aldo-keto reductase (AKR); Mycobacterium smegmatis MSMEG_2407 is a founding member of aldo-keto reductase family 5 member H1 (AKR5H1). It is a NADPH-dependent aldo-keto reductase that reduces methylglyoxal and phenylglyoxal.


Pssm-ID: 381360 [Multi-domain]  Cd Length: 263  Bit Score: 86.06  E-value: 1.25e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941254  28 ISLSDGNNIPLIGLGTY--SDprpvpGKTYVAVKTAIDEGYRHIDGAYVYHNEHEVGEAIrekiAEGKVKREEIFYCGKL 105
Cdd:cd19134    3 VTLNDDNTMPVIGLGVGelSD-----DEAERSVSAALEAGYRLIDTAAAYGNEAAVGRAI----AASGIPRGELFVTTKL 73

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 568941254 106 WNTEHVPSMVLPALERTLKALKLDYIDLYIIELPMA 141
Cdd:cd19134   74 ATPDQGFTASQAACRASLERLGLDYVDLYLIHWPAG 109
AKR_AKR3F1-like cd19072
Thermotoga maritime Tm1743, Escherichia coli YeaE and similar proteins; Thermotoga maritime ...
 33-139 2.29e-19

Thermotoga maritime Tm1743, Escherichia coli YeaE and similar proteins; Thermotoga maritime Tm1743 is a founding member of aldo-keto reductase family 3 member F1 (AKR3F1). It is a aldo/keto reductase family oxidoreductase. Escherichia coli YeaE may act as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.


Pssm-ID: 381298 [Multi-domain]  Cd Length: 263  Bit Score: 82.66  E-value: 2.29e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941254  33 GNNIPLIGLGTY------SDPRPVPGKTYVAVKTAIDEGYRHIDGAYVY---HNEHEVGEAIRekiaegKVKREEIFYCG 103
Cdd:cd19072    1 GEEVPVLGLGTWgigggmSKDYSDDKKAIEALRYAIELGINLIDTAEMYgggHAEELVGKAIK------GFDREDLFITT 74

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 568941254 104 KLWNTEHVPSMVLPALERTLKALKLDYIDLYIIELP 139
Cdd:cd19072   75 KVSPDHLKYDDVIKAAKESLKRLGTDYIDLYLIHWP 110
AKR_AKR3F1 cd19137
Thermotoga maritime Tm1743 and similar proteins; Thermotoga maritime Tm1743 is a founding ...
 33-145 1.58e-16

Thermotoga maritime Tm1743 and similar proteins; Thermotoga maritime Tm1743 is a founding member of aldo-keto reductase family 3 member F1 (AKR3F1). It is a aldo/keto reductase family oxidoreductase.


Pssm-ID: 381363 [Multi-domain]  Cd Length: 260  Bit Score: 74.91  E-value: 1.58e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941254  33 GNNIPLIGLGT----------YSDPRPVPGktyvAVKTAIDEGYRHIDGAYVY---HNEHEVGEAIREkiaegkVKREEI 99
Cdd:cd19137    1 GEKIPALGLGTwgiggfltpdYSRDEEMVE----LLKTAIELGYTHIDTAEMYgggHTEELVGKAIKD------FPREDL 70

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 568941254 100 FYCGKLWNTEHVPSMVLPALERTLKALKLDYIDLYIIELP---MAFKET 145
Cdd:cd19137   71 FIVTKVWPTNLRYDDLLRSLQNSLRRLDTDYIDLYLIHWPnpnIPLEET 119
Aldo_ket_red pfam00248
Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain ...
 39-134 1.69e-15

Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain regulatory domains - these are reported to have oxidoreductase activity.


Pssm-ID: 425554 [Multi-domain]  Cd Length: 290  Bit Score: 72.34  E-value: 1.69e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941254   39 IGLGTYS----DPRPVPGKTYVAVKTAIDEGYRHIDGAYVYH---NEHEVGEAIREKiaegKVKREEIFYCGKL------ 105
Cdd:pfam00248   1 IGLGTWQlgggWGPISKEEALEALRAALEAGINFIDTAEVYGdgkSEELLGEALKDY----PVKRDKVVIATKVpdgdgp 76

                          90       100
                  ....*....|....*....|....*....
gi 568941254  106 WNTEHVPSMVLPALERTLKALKLDYIDLY 134
Cdd:pfam00248  77 WPSGGSKENIRKSLEESLKRLGTDYIDLY 105
AKR_unchar cd19105
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...
 33-134 4.77e-15

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.


Pssm-ID: 381331 [Multi-domain]  Cd Length: 250  Bit Score: 70.69  E-value: 4.77e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941254  33 GNNIPLIGLGTYSDPRPVPGktyvAVKTAIDEGYRHIDGAYVY---HNEHEVGEAIRekiaegKVKREEIFYCGKLWNTE 109
Cdd:cd19105   10 GLKVSRLGFGGGGLPRESPE----LLRRALDLGINYFDTAEGYgngNSEEIIGEALK------GLRRDKVFLATKASPRL 79

                         90       100
                 ....*....|....*....|....*..
gi 568941254 110 HV--PSMVLPALERTLKALKLDYIDLY 134
Cdd:cd19105   80 DKkdKAELLKSVEESLKRLQTDYIDIY 106
AKR_YeaE cd19138
Escherichia coli YeaE and similar proteins; Escherichia coli YeaE is the prototype of this ...
 26-134 1.58e-14

Escherichia coli YeaE and similar proteins; Escherichia coli YeaE is the prototype of this family. It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.


Pssm-ID: 381364 [Multi-domain]  Cd Length: 266  Bit Score: 69.58  E-value: 1.58e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941254  26 HQISLSDGNNIPLIGLGTY---SDPRPvPGKTYVAVKTAIDEGYRHIDGAYVYHN---EHEVGEAIREKiaegkvkREEI 99
Cdd:cd19138    1 RTVTLPDGTKVPALGQGTWymgEDPAK-RAQEIEALRAGIDLGMTLIDTAEMYGDggsEELVGEAIRGR-------RDKV 72

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 568941254 100 FYCGKLWNTEHVPSMVLPALERTLKALKLDYIDLY 134
Cdd:cd19138   73 FLVSKVLPSNASRQGTVRACERSLRRLGTDYLDLY 107
AKR_AKR11B3 cd19085
Synechococcus sp. aldo-keto reductase (SakR1) and similar proteins; Synechococcus sp. SakR1 is ...
 57-140 8.43e-14

Synechococcus sp. aldo-keto reductase (SakR1) and similar proteins; Synechococcus sp. SakR1 is a founding member of aldo-keto reductase family 11 member B3(AKR11B3). It is responsible for methylglyoxal detoxification.


Pssm-ID: 381311 [Multi-domain]  Cd Length: 292  Bit Score: 67.61  E-value: 8.43e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941254  57 AVKTAIDEGYRHIDGAYVY---HNEHEVGEAIREKiaegkvkREEIFYCGKLWNTEHVPSMVLPALERTLKALKLDYIDL 133
Cdd:cd19085   28 TIHAALDAGINFFDTAEAYgdgHSEEVLGKALKGR-------RDDVVIATKVSPDNLTPEDVRKSCERSLKRLGTDYIDL 100


                 ....*..
gi 568941254 134 YIIELPM 140
Cdd:cd19085  101 YQIHWPS 107
AKR_AKR11A1_11D1 cd19083
AKR11A and AKR11D families of aldo-keto reductase (AKR); Bacillus subtilis aldo-keto ...
 39-139 1.96e-12

AKR11A and AKR11D families of aldo-keto reductase (AKR); Bacillus subtilis aldo-keto reductase IolS, also called vegetative protein 147 (VEG147), is a founding member of aldo-keto reductase family 11 member A1 (AKR11A1). It is able to reduce the standard aldo-keto reductase (AKR) substrates DL-glyceraldehyde, D-erythrose, and methylglyoxal in the presence of NADPH, albeit with poor efficiency in vitro. Bacillus aryabhattai aldo keto reductase is a founding member of aldo-keto reductase family 11 member D1 (AKR11D1).


Pssm-ID: 381309 [Multi-domain]  Cd Length: 307  Bit Score: 63.98  E-value: 1.96e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941254  39 IGLGT--------YSDPRPVPGKTYVavKTAIDEGYRHIDGAYVY---HNEHEVGEAIREKiaegkvKREEIFYC--GKL 105
Cdd:cd19083   14 IGLGTnavgghnlYPNLDEEEGKDLV--REALDNGVNLLDTAFIYglgRSEELVGEVLKEY------NRNEVVIAtkGAH 85

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 568941254 106 WNTEH------VPSMVLPALERTLKALKLDYIDLYIIELP 139
Cdd:cd19083   86 KFGGDgsvlnnSPEFLRSAVEKSLKRLNTDYIDLYYIHFP 125
AKR_SF cd06660
Aldo-keto reductase (AKR) superfamily; Aldo-keto reductases (AKRs) are a superfamily of ...
 39-150 5.03e-12

Aldo-keto reductase (AKR) superfamily; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications. Members have very distinct functions and include the prokaryotic 2,5-diketo-D-gluconic acid reductases and beta-keto ester reductases, the eukaryotic aldose reductases, aldehyde reductases, hydroxysteroid dehydrogenases, steroid 5beta-reductases, potassium channel beta-subunits, and aflatoxin aldehyde reductases, among others.


Pssm-ID: 381296 [Multi-domain]  Cd Length: 232  Bit Score: 62.15  E-value: 5.03e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941254  39 IGLGTYSDPRPVPGKTYVA-VKTAIDEGYRHIDGAYVY---HNEHEVGEAIREKiaegkVKREEIFYCGKL---WNTEHV 111
Cdd:cd06660    3 LGLGTMTFGGDGDEEEAFAlLDAALEAGGNFFDTADVYgdgRSERLLGRWLKGR-----GNRDDVVIATKGghpPGGDPS 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 568941254 112 PSMVLPA-----LERTLKALKLDYIDLYIIelpmafkettkHRD 150
Cdd:cd06660   78 RSRLSPEhirrdLEESLRRLGTDYIDLYYL-----------HRD 110
AKR_unchar cd19100
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...
 33-136 1.42e-11

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.


Pssm-ID: 381326 [Multi-domain]  Cd Length: 238  Bit Score: 60.96  E-value: 1.42e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941254  33 GNNIPLIGLGTYSDPRPVPGKTYVAVKTAIDEGYRHIDGAYVYHNEHE-VGEAIREKiaegkvkREEIFYCGKLWNTEhv 111
Cdd:cd19100    8 GLKVSRLGFGGGPLGRLSQEEAAAIIRRALDLGINYFDTAPSYGDSEEkIGKALKGR-------RDKVFLATKTGARD-- 78

                         90       100
                 ....*....|....*....|....*
gi 568941254 112 PSMVLPALERTLKALKLDYIDLYII 136
Cdd:cd19100   79 YEGAKRDLERSLKRLGTDYIDLYQL 103
AKR_unchar cd19099
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...
 39-139 7.84e-11

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.


Pssm-ID: 381325 [Multi-domain]  Cd Length: 316  Bit Score: 59.64  E-value: 7.84e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941254  39 IGLGTYS-DPRPVPGKTYV-AVKTAIDEGYRHIDGAYVYHN---EHEVGEAIREKIAEGKVKREEIFYC---GKLwnTEH 110
Cdd:cd19099    6 LGLGTYRgDSDDETDEEYReALKAALDSGINVIDTAINYRGgrsERLIGKALRELIEKGGIKRDEVVIVtkaGYI--PGD 83

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568941254 111 VPSMVLP--------------------------------ALERTLKALKLDYIDLYIIELP 139
Cdd:cd19099   84 GDEPLRPlkyleeklgrglidvadsaglrhcispayledQIERSLKRLGLDTIDLYLLHNP 144
AKR_AKR11B1-like cd19084
AKR11B1/AKR11B2 subfamily of aldo-keto reductase (AKR); Bacillus subtilis YhdN, also called ...
 35-136 1.72e-10

AKR11B1/AKR11B2 subfamily of aldo-keto reductase (AKR); Bacillus subtilis YhdN, also called general stress protein 69 (GSP69), is a founding member of aldo-keto reductase family 11 member B1 (AKR11B1). It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor. Escherichia coli YdjG is a founding member of aldo-keto reductase family 11 member B2 (AKR11B2). It catalyzes the NADH-dependent reduction of methylglyoxal (2-oxopropanal) in vitro. It may play some role in intestinal colonization.


Pssm-ID: 381310 [Multi-domain]  Cd Length: 296  Bit Score: 58.31  E-value: 1.72e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941254  35 NIPLIGLGTYS----DPRPVPGKTYV-AVKTAIDEGYRHIDGAYVY---HNEHEVGEAIrekiaegKVKREEIFY---CG 103
Cdd:cd19084    3 KVSRIGLGTWAiggtWWGEVDDQESIeAIKAAIDLGINFFDTAPVYgfgHSEEILGKAL-------KGRRDDVVIatkCG 75

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 568941254 104 KLWNTEHV------PSMVLPALERTLKALKLDYIDLYII 136
Cdd:cd19084   76 LRWDGGKGvtkdlsPESIRKEVEQSLRRLQTDYIDLYQI 114
COG1453 COG1453
Predicted oxidoreductase of the aldo/keto reductase family [General function prediction only];
33-136 4.31e-10

Predicted oxidoreductase of the aldo/keto reductase family [General function prediction only];


Pssm-ID: 441062 [Multi-domain]  Cd Length: 365  Bit Score: 57.52  E-value: 4.31e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941254  33 GNNIPLIGLGTYSDPRPVPGKTYVAVKTAIDEGYRHIDGAYVYHN-EHEVGEAIREKiaegkvkREEIFYCGKLWNTEHV 111
Cdd:COG1453   10 GLEVSVLGFGGMRLPRKDEEEAEALIRRAIDNGINYIDTARGYGDsEEFLGKALKGP-------RDKVILATKLPPWVRD 82

                         90       100
                 ....*....|....*....|....*
gi 568941254 112 PSMVLPALERTLKALKLDYIDLYII 136
Cdd:COG1453   83 PEDMRKDLEESLKRLQTDYIDLYLI 107
AKR_Fe-S_oxidoreductase cd19096
Fe-S oxidoreductase and similar proteins; The family includes a group of uncharacterized Fe-S ...
 37-136 4.49e-10

Fe-S oxidoreductase and similar proteins; The family includes a group of uncharacterized Fe-S oxidoreductase that belongs to aldo-keto reductase (AKR) superfamily. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.


Pssm-ID: 381322 [Multi-domain]  Cd Length: 255  Bit Score: 56.80  E-value: 4.49e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941254  37 PLIGLGTY-----SDPRPVPGKTYVAVKTAIDEGYRHIDGAYVYHN---EHEVGEAIREkiaegkVKREEIFYCGKL-WN 107
Cdd:cd19096    1 SVLGFGTMrlpesDDDSIDEEKAIEMIRYAIDAGINYFDTAYGYGGgksEEILGEALKE------GPREKFYLATKLpPW 74

                         90       100
                 ....*....|....*....|....*....
gi 568941254 108 TEHVPSMVLPALERTLKALKLDYIDLYII 136
Cdd:cd19096   75 SVKSAEDFRRILEESLKRLGVDYIDFYLL 103
PdxI COG0667
Pyridoxal reductase PdxI or related oxidoreductase, aldo/keto reductase family [Coenzyme ...
 33-134 6.48e-10

Pyridoxal reductase PdxI or related oxidoreductase, aldo/keto reductase family [Coenzyme transport and metabolism, General function prediction only];


Pssm-ID: 440431 [Multi-domain]  Cd Length: 316  Bit Score: 56.73  E-value: 6.48e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941254  33 GNNIPLIGLGTYS---DPRPVPGKTYVA-VKTAIDEGYRHIDGAYVY---HNEHEVGEAIREKiaegkvKREEIFYCGKL 105
Cdd:COG0667   10 GLKVSRLGLGTMTfggPWGGVDEAEAIAiLDAALDAGINFFDTADVYgpgRSEELLGEALKGR------PRDDVVIATKV 83

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 568941254 106 --------WNTEHVPSMVLPALERTLKALKLDYIDLY 134
Cdd:COG0667   84 grrmgpgpNGRGLSREHIRRAVEASLRRLGTDYIDLY 120
AKR_AKR11C1 cd19086
AKR11C family of aldo-keto reductase (AKR); Bacillus subtilis uncharacterized oxidoreductase ...
 39-134 2.51e-09

AKR11C family of aldo-keto reductase (AKR); Bacillus subtilis uncharacterized oxidoreductase YqkF is a founding member of aldo-keto reductase family 11 member C1 (AKR11C1). It may function as oxidoreductase. This family also includes Bacillus halodurans AKR11C1, an NADPH-dependent 4-hydroxy-2,3-trans-nonenal reductase.


Pssm-ID: 381312 [Multi-domain]  Cd Length: 238  Bit Score: 54.79  E-value: 2.51e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941254  39 IGLGTYSdprpVPGKTYV---------AVKTAIDEGYRHIDGAYVY---HNEHEVGEAIREKiaegkvkREEI------- 99
Cdd:cd19086    6 IGFGTWG----LGGDWWGdvddaeairALRAALDLGINFFDTADVYgdgHSERLLGKALKGR-------RDKVviatkfg 74

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 568941254 100 --FYCGKLWNTEHVPSMVLPALERTLKALKLDYIDLY 134
Cdd:cd19086   75 nrFDGGPERPQDFSPEYIREAVEASLKRLGTDYIDLY 111
AKR_unchar cd19102
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...
 57-139 9.71e-09

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.


Pssm-ID: 381328 [Multi-domain]  Cd Length: 302  Bit Score: 53.45  E-value: 9.71e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941254  57 AVKTAIDEGYRHIDGAYVY---HNEHEVGEAIREKiaegkvkREEIFY---CGKLWNTE------HVPSMVLPALERTLK 124
Cdd:cd19102   31 AIRAALDLGINWIDTAAVYglgHSEEVVGRALKGL-------RDRPIVatkCGLLWDEEgrirrsLKPASIRAECEASLR 103

                         90
                 ....*....|....*
gi 568941254 125 ALKLDYIDLYIIELP 139
Cdd:cd19102  104 RLGVDVIDLYQIHWP 118
AKR_EcYajO-like cd19079
Escherichia coli YajO and similar proteins; Escherichia coli YajO is the prototype of this ...
 39-136 4.05e-08

Escherichia coli YajO and similar proteins; Escherichia coli YajO is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase.


Pssm-ID: 381305 [Multi-domain]  Cd Length: 312  Bit Score: 51.82  E-value: 4.05e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941254  39 IGLGTYSDPRPvPGKTYVA--------VKTAIDEGYRHIDGAYVYHN---EHEVGEAIREKIaegkvKREEIFYCGKLWN 107
Cdd:cd19079   15 LCLGCMSFGDP-KWRPWVLdeeesrpiIKRALDLGINFFDTANVYSGgasEEILGRALKEFA-----PRDEVVIATKVYF 88

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 568941254 108 -TEHVPSM-------VLPALERTLKALKLDYIDLYII 136
Cdd:cd19079   89 pMGDGPNGrglsrkhIMAEVDASLKRLGTDYIDLYQI 125
AKR_AKR11B1 cd19148
Bacillus subtilis aldo-keto reductase YhdN and similar proteins; Bacillus subtilis YhdN, also ...
 39-145 4.60e-08

Bacillus subtilis aldo-keto reductase YhdN and similar proteins; Bacillus subtilis YhdN, also called general stress protein 69 (GSP69), is a founding member of aldo-keto reductase family 11 member B1 (AKR11B1). It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.


Pssm-ID: 381374 [Multi-domain]  Cd Length: 302  Bit Score: 51.54  E-value: 4.60e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941254  39 IGLGTY---------SDPRpvpgKTYVAVKTAIDEGYRHIDGAYVY---HNEHEVGEAIrekiaEGKVKREEIFY---CG 103
Cdd:cd19148    7 IALGTWaiggwmwggTDEK----EAIETIHKALDLGINLIDTAPVYgfgLSEEIVGKAL-----KEYGKRDRVVIatkVG 77

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 568941254 104 KLWNTEHV------PSMVLPALERTLKALKLDYIDLYIIELP---MAFKET 145
Cdd:cd19148   78 LEWDEGGEvvrnssPARIRKEVEDSLRRLQTDYIDLYQVHWPdplVPIEET 128
AKR_AKR15A-like cd19090
AKR15A family of aldo-keto reductase and similar proteins; The AKR15 family includes ...
 39-133 1.66e-07

AKR15A family of aldo-keto reductase and similar proteins; The AKR15 family includes Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD), Pseudomonas sp. D-threo-aldose 1-dehydrogenase (FDH) and similar proteins. PLD (EC1.1.1.107) catalyzes irreversible oxidation of pyridoxal. FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose and, to a much lesser degree, D-arabinose. FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose and, to a much lesser degree, D-arabinose. The family also includes L-galactose dehydrogenase (L-galDH) and D-arabinose 1-dehydrogenase (ARA2). L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+). ARA2 (EC1.1.1.116), also called NAD(+)-specific D-arabinose dehydrogenase, catalyzes the the oxidation of D-arabinose to D-arabinono-1,4-lactone in the presence of NAD(+).


Pssm-ID: 381316 [Multi-domain]  Cd Length: 278  Bit Score: 49.86  E-value: 1.66e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941254  39 IGLGTY---SDPRPVPGKTYVA-VKTAIDEGYRHIDGAYVYHN-EHEVGEAIREkiaegkVKREEIFYCGKL-----WNT 108
Cdd:cd19090    3 LGLGTAglgGVFGGVDDDEAVAtIRAALDLGINYIDTAPAYGDsEERLGLALAE------LPREPLVLSTKVgrlpeDTA 76

                         90       100
                 ....*....|....*....|....*
gi 568941254 109 EHVPSMVLPALERTLKALKLDYIDL 133
Cdd:cd19090   77 DYSADRVRRSVEESLERLGRDRIDL 101
Aldo_ket_red_shaker-like cd19074
Shaker potassium channel beta subunit family and similar proteins; This family includes ...
 58-136 1.99e-07

Shaker potassium channel beta subunit family and similar proteins; This family includes voltage-gated potassium channel subunits, beta-1 (KCAB1B), beta-2 (KCAB2B) and beta-3 (KCAB3B). KCAB1B and KCAB2B are cytoplasmic potassium channel subunits that modulate the characteristics of the channel-forming alpha-subunits. KCAB3B is an accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. The family also includes Drosophila melanogaster Hk protein, a founding member of aldo-keto reductase family 6 member B1 (AKR6B1), as well as voltage-gated potassium channel subunit beta (KCAB) from Arabidopsis thaliana and Egeria densa, founding members of AKR6C1and AKR6C2, respectively. Hk protein, also called hyperkinetic, is a beta subunit of Shaker (Sh) K+ channels and shows high sequence homology to aldoketoreductase. KCAB, also called Shaker channel b-subunit, or K(+) channel subunit beta, or potassium voltage beta 1, or KV-beta1, or KAB1, is a probable accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.


Pssm-ID: 381300 [Multi-domain]  Cd Length: 297  Bit Score: 49.51  E-value: 1.99e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941254  58 VKTAIDEGYRHIDGAYVYHN---EHEVGEAIRekiaegKVKREEIFYCGKL-WNT-----------EHVpsmvLPALERT 122
Cdd:cd19074   28 VRKAYDLGINFFDTADVYAAgqaEEVLGKALK------GWPRESYVISTKVfWPTgpgpndrglsrKHI----FESIHAS 97

                         90
                 ....*....|....
gi 568941254 123 LKALKLDYIDLYII 136
Cdd:cd19074   98 LKRLQLDYVDIYYC 111
AKR_PA4992-like cd19095
Pseudomona aeruginosa PA4992 and similar proteins; Pseudomona aeruginosa PA4992 is the ...
 39-136 8.42e-07

Pseudomona aeruginosa PA4992 and similar proteins; Pseudomona aeruginosa PA4992 is the prototype of this family. It is a putative aldo-keto reductase that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.


Pssm-ID: 381321 [Multi-domain]  Cd Length: 253  Bit Score: 47.61  E-value: 8.42e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941254  39 IGLGTYS--DPRPVPGKTYVA--VKTAIDEGYRHIDGAYVYHN-EHEVGEAIREkiaegkVKREEIFYCGKLWNT----- 108
Cdd:cd19095    3 LGLGTSGigRVWGVPSEAEAArlLNTALDLGINLIDTAPAYGRsEERLGRALAG------LRRDDLFIATKVGTHgeggr 76

                         90       100       110
                 ....*....|....*....|....*....|.
gi 568941254 109 ---EHVPSMVLPALERTLKALKLDYIDLYII 136
Cdd:cd19095   77 drkDFSPAAIRASIERSLRRLGTDYIDLLQL 107
AKR_AKR13A1 cd19144
AKR13A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC ...
 32-134 1.33e-06

AKR13A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC is a founding member of aldo-keto reductase family 13 member A1 (AKR13A1). It catalyzes the reversible reduction of ketones to the respective alcohols using NADP(+) as a hydride donor.


Pssm-ID: 381370 [Multi-domain]  Cd Length: 323  Bit Score: 47.44  E-value: 1.33e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941254  32 DGNNIPLIGLGT-----YSDPRPVPGKTYVAVKTAIDEGYRHIDGAYVY-HNEHEVGEAIreKIAEGKvkREEIFYCGKL 105
Cdd:cd19144    9 NGPSVPALGFGAmglsaFYGPPKPDEERFAVLDAAFELGCTFWDTADIYgDSEELIGRWF--KQNPGK--REKIFLATKF 84

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 568941254 106 WNTEHV----------PSMVLPALERTLKALKLDYIDLY 134
Cdd:cd19144   85 GIEKNVetgeysvdgsPEYVKKACETSLKRLGVDYIDLY 123
AKR_AKR13C1_2 cd19078
AKR13C family of aldo-keto reductase (AKR); The AKR13C family includes Helicobacter pyroli ...
 58-134 1.05e-05

AKR13C family of aldo-keto reductase (AKR); The AKR13C family includes Helicobacter pyroli aldehyde reductase (AKR13C1) and Thermotoga maritima aldo-keto reductase (AKR13C2). Aldehyde reductase (EC 1.1.1.21), also called aldose reductase, is a cytosolic NADPH-dependent oxidoreductase that catalyzes the reduction of a variety of aldehydes and carbonyls, including monosaccharides.


Pssm-ID: 381304 [Multi-domain]  Cd Length: 301  Bit Score: 44.53  E-value: 1.05e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941254  58 VKTAIDEGYRHIDGAYVY---HNEHEVGEAIrekiaegKVKREEIFYCGKL-WNTEHV----------PSMVLPALERTL 123
Cdd:cd19078   31 IRKAVELGITFFDTAEVYgpyTNEELVGEAL-------KPFRDQVVIATKFgFKIDGGkpgplgldsrPEHIRKAVEGSL 103

                         90
                 ....*....|.
gi 568941254 124 KALKLDYIDLY 134
Cdd:cd19078  104 KRLQTDYIDLY 114
AKR_AKR11B2 cd19149
Escherichia coli NADH-specific methylglyoxal reductase (YdjG) and similar proteins; ...
 36-136 1.08e-05

Escherichia coli NADH-specific methylglyoxal reductase (YdjG) and similar proteins; Escherichia coli YdjG is a founding member of aldo-keto reductase family 11 member B2 (AKR11B2). It catalyzes the NADH-dependent reduction of methylglyoxal (2-oxopropanal) in vitro. It may play some role in intestinal colonization.


Pssm-ID: 381375 [Multi-domain]  Cd Length: 315  Bit Score: 44.57  E-value: 1.08e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941254  36 IPLIGLGTYS---DPRPVPGKTYVAVKT---AIDEGYRHIDGAYVY---HNEHEVGEAIREKiaegkvkREEIFY---CG 103
Cdd:cd19149   11 ASVIGLGTWAiggGPWWGGSDDNESIRTihaALDLGINLIDTAPAYgfgHSEEIVGKAIKGR-------RDKVVLatkCG 83

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 568941254 104 KLWNTE---HV-------------PSMVLPALERTLKALKLDYIDLYII 136
Cdd:cd19149   84 LRWDREggsFFfvrdgvtvyknlsPESIREEVEQSLKRLGTDYIDLYQT 132
AKR_AKR13A_13D cd19076
AKR13A and AKR13D families of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto ...
 61-136 1.67e-05

AKR13A and AKR13D families of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC is a founding member of aldo-keto reductase family 13 member A1 (AKR13A1). It catalyzes the reversible reduction of ketones to the respective alcohols using NADP(+) as a hydride donor. Rauvolfia serpentina PR is a founding member of aldo-keto reductase family 13 member D1 (AKR13D1). It catalyzes the NADPH-dependent reduction of the aldehyde perakine to yield the alcohol raucaffrinoline in the biosynthetic pathway of ajmaline in Rauvolfia, a key step in indole alkaloid biosynthesis. This family also includes Arabidopsis thaliana aldo-keto reductases, ALKR1-6.


Pssm-ID: 381302 [Multi-domain]  Cd Length: 303  Bit Score: 44.13  E-value: 1.67e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941254  61 AIDEGYRHIDGAYVY---HNEHEVGEAIREKiaegkvkREEIFY---CGKLWN--TEHV-----PSMVLPALERTLKALK 127
Cdd:cd19076   41 ALELGVTFLDTADMYgpgTNEELLGKALKDR-------RDEVVIatkFGIVRDpgSGFRgvdgrPEYVRAACEASLKRLG 113


                 ....*....
gi 568941254 128 LDYIDLYII 136
Cdd:cd19076  114 TDVIDLYYQ 122
AKR_PsAKR cd19091
Polaromonas Sp. aldo-keto reductase and similar proteins; The prototype of this family is an ...
 58-134 2.36e-04

Polaromonas Sp. aldo-keto reductase and similar proteins; The prototype of this family is an uncharacterized aldo-keto reductase from Polaromonas sp.


Pssm-ID: 381317 [Multi-domain]  Cd Length: 319  Bit Score: 40.67  E-value: 2.36e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941254  58 VKTAIDEGYRHIDGAYVYHN---EHEVGEAIREKiaegkvkREEIFYCGK--LWNTEHVPSM------VLPALERTLKAL 126
Cdd:cd19091   45 VDIALDAGINFFDTADVYSEgesEEILGKALKGR-------RDDVLIATKvrGRMGEGPNDVglsrhhIIRAVEASLKRL 117


                 ....*...
gi 568941254 127 KLDYIDLY 134
Cdd:cd19091  118 GTDYIDLY 125
AKR_AKR10A1_2 cd19082
AKR10A family of aldo-keto reductase (AKR); Streptomyces bluensis aldo-keto reductase (BlmT) ...
 69-150 3.79e-04

AKR10A family of aldo-keto reductase (AKR); Streptomyces bluensis aldo-keto reductase (BlmT) and Streptomyces glaucescens aldo-keto reductase (StrT) are founding members of aldo-keto reductase family 10 member A1 (AKR10A1) and A2 (AKR10A2). BlmT is bluensomycin aldo-keto reductase (AKR) and StrT is streptomycin AKR.


Pssm-ID: 381308 [Multi-domain]  Cd Length: 291  Bit Score: 39.84  E-value: 3.79e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941254  69 IDGAYVYHNEHEVG---EAIREKIAEGKvKREEIFYCGK----LWNTEHVPSM----VLPALERTLKALKLDYIDLYIIe 137
Cdd:cd19082   34 IDTARVYGDWVERGaseRVIGEWLKSRG-NRDKVVIATKgghpDLEDMSRSRLspedIRADLEESLERLGTDYIDLYFL- 111

                         90
                 ....*....|...
gi 568941254 138 lpmafkettkHRD 150
Cdd:cd19082  112 ----------HRD 114
AKR_AKR13D1 cd19145
AKR13D family of aldo-keto reductase (AKR); Rauvolfia serpentina PR is a founding member of ...
 31-134 4.56e-04

AKR13D family of aldo-keto reductase (AKR); Rauvolfia serpentina PR is a founding member of aldo-keto reductase family 13 member D1 (AKR13D1). It catalyzes the NADPH-dependent reduction of the aldehyde perakine to yield the alcohol raucaffrinoline in the biosynthetic pathway of ajmaline in Rauvolfia, a key step in indole alkaloid biosynthesis. This family also includes Arabidopsis thaliana aldo-keto reductases, ALKR1-6.


Pssm-ID: 381371 [Multi-domain]  Cd Length: 304  Bit Score: 39.72  E-value: 4.56e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941254  31 SDGNNIPLIGLG----TYSDPRPVPGKTYVAV-KTAIDEGYRHIDGAYVY---HNEHEVGEAIREKIAEgKVKREEIFYC 102
Cdd:cd19145    7 SQGLEVSAQGLGcmglSGDYGAPKPEEEGIALiHHAFNSGVTFLDTSDIYgpnTNEVLLGKALKDGPRE-KVQLATKFGI 85

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 568941254 103 ----GKLWNTEHVPSMVLPALERTLKALKLDYIDLY 134
Cdd:cd19145   86 heigGSGVEVRGDPAYVRAACEASLKRLDVDYIDLY 121
AKR_unchar cd19104
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...
 27-136 7.76e-04

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.


Pssm-ID: 381330 [Multi-domain]  Cd Length: 321  Bit Score: 39.17  E-value: 7.76e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941254  27 QISLSDGNNIPLIGLGTYSDPRpvpgktyVAVKTAIDEGYRHIDGAYVY---HNEHEVGEAIREKiaegkvkREEIFYCG 103
Cdd:cd19104   14 ELTFGGGGIGGLMGRTTREEQI-------AAVRRALDLGINFFDTAPSYgdgKSEENLGRALKGL-------PAGPYITT 79

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 568941254 104 K----LWNTEHVPSMVLPALERTLKALKLDYIDLYII 136
Cdd:cd19104   80 KvrldPDDLGDIGGQIERSVEKSLKRLKRDSVDLLQL 116
AKR_BsYcsN_EcYdhF-like cd19092
Bacillus subtilis YcsN, Escherichia coli YdhF and similar proteins; Bacillus subtilis YcsN and ...
 57-136 6.94e-03

Bacillus subtilis YcsN, Escherichia coli YdhF and similar proteins; Bacillus subtilis YcsN and Escherichia coli YdhF are prototypes of this family. They are uncharacterized aldo/keto reductase family oxidoreductases.


Pssm-ID: 381318 [Multi-domain]  Cd Length: 287  Bit Score: 35.99  E-value: 6.94e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941254  57 AVKTAIDEGYRHIDGAYVYHN---EHEVGEAIREKiaegKVKREEIFY---CG-------KLWNTEHV---PSMVLPALE 120
Cdd:cd19092   29 LIEAALELGITTFDHADIYGGgkcEELFGEALALN----PGLREKIEIqtkCGirlgddpRPGRIKHYdtsKEHILASVE 104

                         90
                 ....*....|....*.
gi 568941254 121 RTLKALKLDYIDLYII 136
Cdd:cd19092  105 GSLKRLGTDYLDLLLL 120
AKR_AKR15A1 cd19161
Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD) and similar proteins; Microbacterium ...
 37-88 7.55e-03

Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD) and similar proteins; Microbacterium luteolum PLD (EC1.1.1.107) is a founding member of aldo-keto reductase family 15 member A1 (AKR15A1). It catalyzes irreversible oxidation of pyridoxal.


Pssm-ID: 381387 [Multi-domain]  Cd Length: 310  Bit Score: 36.15  E-value: 7.55e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568941254  37 PLIGLGT------YsdpRPVPGKTYVAV-KTAIDEGYRHIDGAYVYHN---EHEVGEAIREK 88
Cdd:cd19161    1 SELGLGTaglgnlY---TAVSNADADATlDAAWDSGIRYFDTAPMYGHglaEHRLGDFLREK 59
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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