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Conserved domains on  [gi|568954615|ref|XP_006509379|]
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zinc finger protein 42 isoform X1 [Mus musculus]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
198-275 3.52e-10

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 60.09  E-value: 3.52e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954615 198 RHVCAECGKAFTESSKLKRHF--LVHTGE--KPYQCTFEGCGKRFSLDFNLRTHIRIHTGERRFVCPFDGCEKSFIQSNN 273
Cdd:COG5048  289 PIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLN 368


                 ..
gi 568954615 274 QK 275
Cdd:COG5048  369 NE 370
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
198-275 3.52e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 60.09  E-value: 3.52e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954615 198 RHVCAECGKAFTESSKLKRHF--LVHTGE--KPYQCTFEGCGKRFSLDFNLRTHIRIHTGERRFVCPFDGCEKSFIQSNN 273
Cdd:COG5048  289 PIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLN 368


                 ..
gi 568954615 274 QK 275
Cdd:COG5048  369 NE 370
zf-H2C2_2 pfam13465
Zinc-finger double domain;
243-270 1.02e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 1.02e-04
                          10        20
                  ....*....|....*....|....*...
gi 568954615  243 NLRTHIRIHTGERRFVCPFdgCEKSFIQ 270
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPE--CGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
198-275 3.52e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 60.09  E-value: 3.52e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954615 198 RHVCAECGKAFTESSKLKRHF--LVHTGE--KPYQCTFEGCGKRFSLDFNLRTHIRIHTGERRFVCPFDGCEKSFIQSNN 273
Cdd:COG5048  289 PIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLN 368


                 ..
gi 568954615 274 QK 275
Cdd:COG5048  369 NE 370
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
161-284 3.24e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 51.24  E-value: 3.24e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954615 161 GVYCGVLSMLECPQAGCKKKLRDKTALRKHMLVHGprrhvCAECGKAFTESSKLKRHFLVHTGEKPYQCTFEGCGKRFSL 240
Cdd:COG5048    1 ATLTSSQSSSSNNSVLSSTPKSTLKSLSNAPRPDS-----CPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSR 75

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 568954615 241 DFNLRTHIRIHTGERRFVcpfdgCEKSFIQSNNQKIHILTHAKA 284
Cdd:COG5048   76 PLELSRHLRTHHNNPSDL-----NSKSLPLSNSKASSSSLSSSS 114
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
167-283 2.36e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.46  E-value: 2.36e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954615 167 LSMLECPQAGCKKKLRDKTALR-----KHMLVHGPRRHVCAECGKAFTESSKLKRHFLVHTG-EKPYQCTfeGCGKRFSL 240
Cdd:COG5048  224 SSSLPLTTNSQLSPKSLLSQSPsslssSDSSSSASESPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSK--QCNISFSR 301

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 568954615 241 DFNLRTHIR--IHTGE--RRFVCPFDGCEKSFIQSNNQKIHILTHAK 283
Cdd:COG5048  302 SSPLTRHLRsvNHSGEslKPFSCPYSLCGKLFSRNDALKRHILLHTS 348
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
167-281 6.50e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.92  E-value: 6.50e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954615 167 LSMLECPQAGCKKKLRDKTALRKHMLVHGPRRHVCA---ECGKAFTESSKLKRHFLVH-----TGEKPYQCTFEGCGKRF 238
Cdd:COG5048  319 LKPFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEkllNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETLSNSCIRNF 398

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 568954615 239 SLDFNLRTHIRIHTGERRFVCPFDGCEKSFIQSNNQKIHILTH 281
Cdd:COG5048  399 KRDSNLSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIH 441
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 172-248 7.44e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.94  E-value: 7.44e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568954615 172 CPQAGCKKKLRDKTALRKHMLvHGprrhvcaECGKAFTESSKLKRHFLVHTGEKPYQCTFegCGKRFSLDFNLRTHI 248
Cdd:COG5189  352 CPVEGCNKKYKNQNGLKYHML-HG-------HQNQKLHENPSPEKMNIFSAKDKPYRCEV--CDKRYKNLNGLKYHR 418
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
172-281 8.12e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.92  E-value: 8.12e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954615 172 CPQAGCKKKLRDKTALRKHMLV-----HGPRRHVCAE--CGKAFTESSKLKRHFLVHTGEKPYQCTFEGCGKRFSLDFNL 244
Cdd:COG5048  290 IKSKQCNISFSRSSPLTRHLRSvnhsgESLKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLNN 369

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 568954615 245 RTH-----IRIHTGERRFVCPFDGCEKSFIQSNNQKIHILTH 281
Cdd:COG5048  370 EPPqslqqYKDLKNDKKSETLSNSCIRNFKRDSNLSLHIITH 411
zf-H2C2_2 pfam13465
Zinc-finger double domain;
243-270 1.02e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 1.02e-04
                          10        20
                  ....*....|....*....|....*...
gi 568954615  243 NLRTHIRIHTGERRFVCPFdgCEKSFIQ 270
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPE--CGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
214-239 2.27e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 2.27e-04
                          10        20
                  ....*....|....*....|....*.
gi 568954615  214 LKRHFLVHTGEKPYQCTFegCGKRFS 239
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPE--CGKSFK 25
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 199-221 4.72e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 33.81  E-value: 4.72e-03
                          10        20
                  ....*....|....*....|...
gi 568954615  199 HVCAECGKAFTESSKLKRHFLVH 221
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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