NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|568958572|ref|XP_006509946|]
View 

alkylated DNA repair protein alkB homolog 8 isoform X4 [Mus musculus]

Protein Classification

class I SAM-dependent methyltransferase( domain architecture ID 10549394)

class I SAM-dependent methyltransferase catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor; similar to Saccharomyces cerevisiae tRNA (carboxymethyluridine(34)-5-O)-methyltransferase

CATH:  2.20.25.110
EC:  2.1.1.-
Gene Ontology:  GO:0032259|GO:0008757|GO:0008168|GO:1904047
PubMed:  12826405
SCOP:  3000118

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 120-246 2.64e-21

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


:

Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 89.28  E-value: 2.64e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568958572 120 YNEIASHFSSTRhspwpRIVEFLKALPsGSIVADIGCGNGKYLGI--NKDLYMIGCDRSQNLVDICRER------QFQAL 191
Cdd:COG2226    1 FDRVAARYDGRE-----ALLAALGLRP-GARVLDLGCGTGRLALAlaERGARVTGVDISPEMLELARERaaeaglNVEFV 74

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 568958572 192 VCDALAVPVRSGSCDACISIAVIHHFataERRVEALQELARLLRPGGQALIYVWA 246
Cdd:COG2226   75 VGDAEDLPFPDGSFDLVISSFVLHHL---PDPERALAEIARVLKPGGRLVVVDFS 126
AlkB super family cl43793
Alkylated DNA repair dioxygenase AlkB [Replication, recombination and repair];
3-79 4.45e-04

Alkylated DNA repair dioxygenase AlkB [Replication, recombination and repair];


The actual alignment was detected with superfamily member COG3145:

Pssm-ID: 442379  Cd Length: 200  Bit Score: 40.91  E-value: 4.45e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568958572   3 FKHPE--GVTVQVMLPRRSLLVMTGESRYLWTHGITPRKFDTvqaseqfkggiitsdigdltlskrGMRTSFTFRKVRR 79
Cdd:COG3145  146 FGHKErkDPTRSLPLEHGDLLVMGGPTQLAWQHGVPKTKKGT------------------------GPRINLTFRRIGP 200
 
Name Accession Description Interval E-value
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 120-246 2.64e-21

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 89.28  E-value: 2.64e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568958572 120 YNEIASHFSSTRhspwpRIVEFLKALPsGSIVADIGCGNGKYLGI--NKDLYMIGCDRSQNLVDICRER------QFQAL 191
Cdd:COG2226    1 FDRVAARYDGRE-----ALLAALGLRP-GARVLDLGCGTGRLALAlaERGARVTGVDISPEMLELARERaaeaglNVEFV 74

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 568958572 192 VCDALAVPVRSGSCDACISIAVIHHFataERRVEALQELARLLRPGGQALIYVWA 246
Cdd:COG2226   75 VGDAEDLPFPDGSFDLVISSFVLHHL---PDPERALAEIARVLKPGGRLVVVDFS 126
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 151-238 1.36e-19

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 83.00  E-value: 1.36e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568958572  151 VADIGCGNGKYLGINKDLY---MIGCDRSQNLVDICRER------QFQALVCDALAVPVRSGSCDACISIAVIHHFATAE 221
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRGgarVTGVDLSPEMLERARERaaeaglNVEFVQGDAEDLPFPDGSFDLVVSSGVLHHLPDPD 80

                          90
                  ....*....|....*..
gi 568958572  222 RRvEALQELARLLRPGG 238
Cdd:pfam13649  81 LE-AALREIARVLKPGG 96
PRK08317 PRK08317
hypothetical protein; Provisional
 137-242 1.66e-14

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 72.66  E-value: 1.66e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568958572 137 RIVEFLkALPSGSIVADIGCGNG---KYLG--INKDLYMIGCDRSQNLVDICRER------QFQALVCDALAVPVRSGSC 205
Cdd:PRK08317  10 RTFELL-AVQPGDRVLDVGCGPGndaRELArrVGPEGRVVGIDRSEAMLALAKERaaglgpNVEFVRGDADGLPFPDGSF 88

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 568958572 206 DACISIAVIHHFATAERrveALQELARLLRPGGQALI 242
Cdd:PRK08317  89 DAVRSDRVLQHLEDPAR---ALAEIARVLRPGGRVVV 122
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 151-242 7.41e-10

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 55.90  E-value: 7.41e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568958572 151 VADIGCGNGKY---LGINKDLYMIGCDRSQNLVDICRERQFQA-------LVCDALAVP-VRSGSCDACISIAVIHHFAt 219
Cdd:cd02440    2 VLDLGCGTGALalaLASGPGARVTGVDISPVALELARKAAAALladnvevLKGDAEELPpEADESFDVIISDPPLHHLV- 80

                         90       100
                 ....*....|....*....|...
gi 568958572 220 aERRVEALQELARLLRPGGQALI 242
Cdd:cd02440   81 -EDLARFLEEARRLLKPGGVLVL 102
AlkB COG3145
Alkylated DNA repair dioxygenase AlkB [Replication, recombination and repair];
3-79 4.45e-04

Alkylated DNA repair dioxygenase AlkB [Replication, recombination and repair];


Pssm-ID: 442379  Cd Length: 200  Bit Score: 40.91  E-value: 4.45e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568958572   3 FKHPE--GVTVQVMLPRRSLLVMTGESRYLWTHGITPRKFDTvqaseqfkggiitsdigdltlskrGMRTSFTFRKVRR 79
Cdd:COG3145  146 FGHKErkDPTRSLPLEHGDLLVMGGPTQLAWQHGVPKTKKGT------------------------GPRINLTFRRIGP 200
 
Name Accession Description Interval E-value
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 120-246 2.64e-21

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 89.28  E-value: 2.64e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568958572 120 YNEIASHFSSTRhspwpRIVEFLKALPsGSIVADIGCGNGKYLGI--NKDLYMIGCDRSQNLVDICRER------QFQAL 191
Cdd:COG2226    1 FDRVAARYDGRE-----ALLAALGLRP-GARVLDLGCGTGRLALAlaERGARVTGVDISPEMLELARERaaeaglNVEFV 74

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 568958572 192 VCDALAVPVRSGSCDACISIAVIHHFataERRVEALQELARLLRPGGQALIYVWA 246
Cdd:COG2226   75 VGDAEDLPFPDGSFDLVISSFVLHHL---PDPERALAEIARVLKPGGRLVVVDFS 126
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 151-238 1.36e-19

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 83.00  E-value: 1.36e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568958572  151 VADIGCGNGKYLGINKDLY---MIGCDRSQNLVDICRER------QFQALVCDALAVPVRSGSCDACISIAVIHHFATAE 221
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRGgarVTGVDLSPEMLERARERaaeaglNVEFVQGDAEDLPFPDGSFDLVVSSGVLHHLPDPD 80

                          90
                  ....*....|....*..
gi 568958572  222 RRvEALQELARLLRPGG 238
Cdd:pfam13649  81 LE-AALREIARVLKPGG 96
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 153-242 1.40e-19

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 82.71  E-value: 1.40e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568958572  153 DIGCGNGKYLGINKDLYM--IGCDRSQNLVDICRER----QFQALVCDALAVPVRSGSCDACISIAVIHHFataERRVEA 226
Cdd:pfam08241   2 DVGCGTGLLTELLARLGArvTGVDISPEMLELAREKapreGLTFVVGDAEDLPFPDNSFDLVLSSEVLHHV---EDPERA 78

                          90
                  ....*....|....*.
gi 568958572  227 LQELARLLRPGGQALI 242
Cdd:pfam08241  79 LREIARVLKPGGILII 94
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 128-242 1.04e-16

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 75.82  E-value: 1.04e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568958572 128 SSTRHSPW-PRIVEFL-KALPSGSIVADIGCGNGKYL------GINkdlyMIGCDRSQNLVDICRER----QFQALVCDA 195
Cdd:COG2227    3 DPDARDFWdRRLAALLaRLLPAGGRVLDVGCGTGRLAlalarrGAD----VTGVDISPEALEIARERaaelNVDFVQGDL 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 568958572 196 LAVPVRSGSCDACISIAVIHHFATAErrvEALQELARLLRPGGQALI 242
Cdd:COG2227   79 EDLPLEDGSFDLVICSEVLEHLPDPA---ALLRELARLLKPGGLLLL 122
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 125-250 7.24e-15

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 72.64  E-value: 7.24e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568958572 125 SHFSSTRHSP-WPRIVEFLKALPSGSIVADIGCGNGKYLGINKDLY---MIGCDRSQNLVDICRERQFQA-------LVC 193
Cdd:COG0500    3 DSYYSDELLPgLAALLALLERLPKGGRVLDLGCGTGRNLLALAARFggrVIGIDLSPEAIALARARAAKAglgnvefLVA 82

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 568958572 194 DALA-VPVRSGSCDACISIAVIHHFAtAERRVEALQELARLLRPGGQALIYVWAMEQE 250
Cdd:COG0500   83 DLAElDPLPAESFDLVVAFGVLHHLP-PEEREALLRELARALKPGGVLLLSASDAAAA 139
PRK08317 PRK08317
hypothetical protein; Provisional
 137-242 1.66e-14

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 72.66  E-value: 1.66e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568958572 137 RIVEFLkALPSGSIVADIGCGNG---KYLG--INKDLYMIGCDRSQNLVDICRER------QFQALVCDALAVPVRSGSC 205
Cdd:PRK08317  10 RTFELL-AVQPGDRVLDVGCGPGndaRELArrVGPEGRVVGIDRSEAMLALAKERaaglgpNVEFVRGDADGLPFPDGSF 88

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 568958572 206 DACISIAVIHHFATAERrveALQELARLLRPGGQALI 242
Cdd:PRK08317  89 DAVRSDRVLQHLEDPAR---ALAEIARVLRPGGRVVV 122
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 137-244 8.29e-14

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 68.80  E-value: 8.29e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568958572 137 RIVEFLkALPSGSIVADIGCGNG---KYLGINKDLYMIGCDRSQNLVDICRER--------QFQALVCDALAVPvRSGSC 205
Cdd:COG2230   42 LILRKL-GLKPGMRVLDIGCGWGglaLYLARRYGVRVTGVTLSPEQLEYARERaaeagladRVEVRLADYRDLP-ADGQF 119

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 568958572 206 DACISIAVIHHFATAERRvEALQELARLLRPGGQALIYV 244
Cdd:COG2230  120 DAIVSIGMFEHVGPENYP-AYFAKVARLLKPGGRLLLHT 157
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
113-238 4.92e-12

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 64.25  E-value: 4.92e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568958572 113 QKHVHQVYNEIA----SHFSSTRHSPWPRIV--EFLKALPSGSI--VADIGCGNGkYLGI---NKDLYMIGCDRSQNLVD 181
Cdd:COG4976    4 DAYVEALFDQYAdsydAALVEDLGYEAPALLaeELLARLPPGPFgrVLDLGCGTG-LLGEalrPRGYRLTGVDLSEEMLA 82

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 568958572 182 ICRERQFQA--LVCDALAVPVRSGSCDACISIAVIHHFATAERrveALQELARLLRPGG 238
Cdd:COG4976   83 KAREKGVYDrlLVADLADLAEPDGRFDLIVAADVLTYLGDLAA---VFAGVARALKPGG 138
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
151-244 5.51e-12

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 61.76  E-value: 5.51e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568958572 151 VADIGCGNGKY----LGINKDLYMIGCDRSQNLVDICRER--QFQALVCDALAVPVRsGSCDACISIAVIHHFataERRV 224
Cdd:COG4106    5 VLDLGCGTGRLtallAERFPGARVTGVDLSPEMLARARARlpNVRFVVADLRDLDPP-EPFDLVVSNAALHWL---PDHA 80

                         90       100
                 ....*....|....*....|
gi 568958572 225 EALQELARLLRPGGQALIYV 244
Cdd:COG4106   81 ALLARLAAALAPGGVLAVQV 100
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 105-242 1.36e-10

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 60.94  E-value: 1.36e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568958572 105 SKEALELEQKHVHQVYNEIASHF-------SSTRHSPWPRivEFLKAL--PSGSIVADIGCGNG-------KYLGINKdl 168
Cdd:PRK00216   2 MTVAEEEKQEKVAEMFDSIAPKYdlmndllSFGLHRVWRR--KTIKWLgvRPGDKVLDLACGTGdlaialaKAVGKTG-- 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568958572 169 YMIGCDRSQNLVDICRER--------QFQALVCDALAVPVRSGSCDaCISIA-----VIHhfataerRVEALQELARLLR 235
Cdd:PRK00216  78 EVVGLDFSEGMLAVGREKlrdlglsgNVEFVQGDAEALPFPDNSFD-AVTIAfglrnVPD-------IDKALREMYRVLK 149


                 ....*..
gi 568958572 236 PGGQALI 242
Cdd:PRK00216 150 PGGRLVI 156
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 151-242 7.41e-10

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 55.90  E-value: 7.41e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568958572 151 VADIGCGNGKY---LGINKDLYMIGCDRSQNLVDICRERQFQA-------LVCDALAVP-VRSGSCDACISIAVIHHFAt 219
Cdd:cd02440    2 VLDLGCGTGALalaLASGPGARVTGVDISPVALELARKAAAALladnvevLKGDAEELPpEADESFDVIISDPPLHHLV- 80

                         90       100
                 ....*....|....*....|...
gi 568958572 220 aERRVEALQELARLLRPGGQALI 242
Cdd:cd02440   81 -EDLARFLEEARRLLKPGGVLVL 102
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 153-238 4.75e-08

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 50.44  E-value: 4.75e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568958572  153 DIGCGNG----KYLGINKDLYMIGCDRSQNLVDICRER--QFQALVCDALAVPVR------SGSCDACISIAVIHHFATa 220
Cdd:pfam08242   2 EIGCGTGtllrALLEALPGLEYTGLDISPAALEAARERlaALGLLNAVRVELFQLdlgeldPGSFDVVVASNVLHHLAD- 80

                          90
                  ....*....|....*...
gi 568958572  221 erRVEALQELARLLRPGG 238
Cdd:pfam08242  81 --PRAVLRNIRRLLKPGG 96
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 147-272 8.77e-06

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 45.49  E-value: 8.77e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568958572  147 SGSIVADIGCGNGkYLGI------NKDLYMIGCDRSQNLVDICRER-------QFQALVCDALAVP--VRSGSCDACISI 211
Cdd:pfam13847   3 KGMRVLDLGCGTG-HLSFelaeelGPNAEVVGIDISEEAIEKARENaqklgfdNVEFEQGDIEELPelLEDDKFDVVISN 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568958572  212 AVIHHFAtaeRRVEALQELARLLRPGGQALI-YVWAMEQEYKN--QKSKYLRGKRISQGDKDEL 272
Cdd:pfam13847  82 CVLNHIP---DPDKVLQEILRVLKPGGRLIIsDPDSLAELPAHvkEDSTYYAGCVGGAILKKKL 142
Ubie_methyltran pfam01209
ubiE/COQ5 methyltransferase family;
112-239 1.88e-05

ubiE/COQ5 methyltransferase family;


Pssm-ID: 395966 [Multi-domain]  Cd Length: 228  Bit Score: 45.51  E-value: 1.88e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568958572  112 EQKhVHQVYNEIASHF-------SSTRHSPWPRIVEFLKALPSGSIVADIGCGNGKYL-----GINKDLYMIGCDRSQNL 179
Cdd:pfam01209   1 EQR-VGDVFSSVASKYdlmndviSFGIHRLWKDFTMKCMGVKRGNKFLDVAGGTGDWTfglsdSAGSSGKVVGLDINENM 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568958572  180 VDICRER-------QFQALVCDALAVPVRSGSCDaCISIAV-IHHFATaerRVEALQELARLLRPGGQ 239
Cdd:pfam01209  80 LKEGEKKakeegkyNIEFLQGNAEELPFEDDSFD-IVTISFgLRNFPD---YLKVLKEAFRVLKPGGR 143
RsmC COG2813
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 141-242 8.75e-05

16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA G1207 methylase RsmC is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 442062 [Multi-domain]  Cd Length: 191  Bit Score: 43.25  E-value: 8.75e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568958572 141 FLKALP--SGSIVADIGCGNGkYLGI-----NKDLYMIGCDRSQNLVDICRE-------RQFQALVCDALAvPVRSGSCD 206
Cdd:COG2813   41 LLEHLPepLGGRVLDLGCGYG-VIGLalakrNPEARVTLVDVNARAVELARAnaaanglENVEVLWSDGLS-GVPDGSFD 118

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 568958572 207 ACISIAVIHhfATAERRVEALQEL----ARLLRPGGQALI 242
Cdd:COG2813  119 LILSNPPFH--AGRAVDKEVAHALiadaARHLRPGGELWL 156
PRK15068 PRK15068
tRNA 5-methoxyuridine(34)/uridine 5-oxyacetic acid(34) synthase CmoB;
135-239 1.15e-04

tRNA 5-methoxyuridine(34)/uridine 5-oxyacetic acid(34) synthase CmoB;


Pssm-ID: 237898  Cd Length: 322  Bit Score: 43.69  E-value: 1.15e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568958572 135 WPRIVEFLKALpSGSIVADIGCGNGKY----LGINKDLyMIGCDRSQNLVdiCrerQFQA---LVCDALAV---PVR--- 201
Cdd:PRK15068 111 WDRVLPHLSPL-KGRTVLDVGCGNGYHmwrmLGAGAKL-VVGIDPSQLFL--C---QFEAvrkLLGNDQRAhllPLGieq 183

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 568958572 202 ---SGSCDACISIAVIHHfataeRR--VEALQELARLLRPGGQ 239
Cdd:PRK15068 184 lpaLKAFDTVFSMGVLYH-----RRspLDHLKQLKDQLVPGGE 221
Methyltransf_23 pfam13489
Methyltransferase domain; This family appears to be a methyltransferase domain.
 131-246 1.31e-04

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 404385 [Multi-domain]  Cd Length: 162  Bit Score: 42.03  E-value: 1.31e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568958572  131 RHSPWPRIVEFL-KALPSGSIVADIGCGNGKYLGINKDLY--MIGCDRSQNLVDICRERQFQALVCDALAvPVRSGSCDA 207
Cdd:pfam13489   5 RERLLADLLLRLlPKLPSPGRVLDFGCGTGIFLRLLRAQGfsVTGVDPSPIAIERALLNVRFDQFDEQEA-AVPAGKFDV 83

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 568958572  208 CISIAVIHHFATAERrveALQELARLLRPGGQALIYVWA 246
Cdd:pfam13489  84 IVAREVLEHVPDPPA---LLRQIAALLKPGGLLLLSTPL 119
AlkB COG3145
Alkylated DNA repair dioxygenase AlkB [Replication, recombination and repair];
3-79 4.45e-04

Alkylated DNA repair dioxygenase AlkB [Replication, recombination and repair];


Pssm-ID: 442379  Cd Length: 200  Bit Score: 40.91  E-value: 4.45e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568958572   3 FKHPE--GVTVQVMLPRRSLLVMTGESRYLWTHGITPRKFDTvqaseqfkggiitsdigdltlskrGMRTSFTFRKVRR 79
Cdd:COG3145  146 FGHKErkDPTRSLPLEHGDLLVMGGPTQLAWQHGVPKTKKGT------------------------GPRINLTFRRIGP 200
Methyltransf_4 pfam02390
Putative methyltransferase; This is a family of putative methyltransferases. The aligned ...
 147-239 5.05e-03

Putative methyltransferase; This is a family of putative methyltransferases. The aligned region contains the GXGXG S-AdoMet binding site suggesting a putative methyltransferase activity.


Pssm-ID: 367068  Cd Length: 173  Bit Score: 37.65  E-value: 5.05e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568958572  147 SGSIVADIGCGNGKYL----GINKDLYMIGCDRSQNLVDIC----RERQFQALVC---DALAV---PVRSGSCDAcISI- 211
Cdd:pfam02390   1 DAPVFLEIGCGMGGFLvamaKANPDKNFIGIEIRVPGVAKAlkkiDALGLQNLRIlcgNALDVlpnYFPPGSLQK-IFIn 79

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 568958572  212 ------AVIHHfataERRV---EALQELARLLRPGGQ 239
Cdd:pfam02390  80 fpdpwpKKRHH----KRRLlqpEFLKEYARVLKPGGV 112
Pox_MCEL pfam03291
mRNA capping enzyme; This family of enzymes are related to pfam03919.
 151-242 5.86e-03

mRNA capping enzyme; This family of enzymes are related to pfam03919.


Pssm-ID: 281307 [Multi-domain]  Cd Length: 332  Bit Score: 38.57  E-value: 5.86e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568958572  151 VADIGCGNG----KYLGINKDLYmIGCDRSQNLVDICRER-------------QFQA--LVCDALAVPVR------SGSC 205
Cdd:pfam03291  67 VLDLGCGKGgdleKWFKGGISQL-IGTDIAEVSIEQCRERynklrsgnkskyyKFDAefITGDCFVSSLRevfedpFGKF 145

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 568958572  206 DACISIAVIHH-FATAERRVEALQELARLLRPGGQALI 242
Cdd:pfam03291 146 DIVSCQFAIHYsFESEEKARTMLRNVAELLASGGVFIG 183
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH