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Conserved domains on  [gi|568959401|ref|XP_006510345|]
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zinc finger protein 317 isoform X1 [Mus musculus]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12204268)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development, and in regulating viral replication and transcription

CATH:  3.30.160.60
Gene Ontology:  GO:0003700|GO:0046872
PubMed:  22803940
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
60-118 6.60e-29

krueppel associated box;


:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 109.22  E-value: 6.60e-29
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 568959401    60 VTFQDIAVDFTEKEWPLLDSSQRKLYKDVMLENYSNLSSLGYQVGKPRLISHLEQEEDL 118
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEP 59
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
223-570 6.95e-09

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.55  E-value: 6.95e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568959401 223 HKCHQCQKAFTTSASLTRHHRIHTGEKPYECS--SCGKAFNDPSALRSHTRTHLKE------------------------ 276
Cdd:COG5048   34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNpsdlnskslplsnskasssslsss 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568959401 277 -----KPFDCSQCSNAFRTLSALKIHMRVHTGERPYKCDECGKAYGRS----------------------CHLIAHKRTH 329
Cdd:COG5048  114 ssnsnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTpqsnslhpplpanslskdpssnLSLLISSNVS 193

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568959401 330 TGERPYECQDCGKAFQHPSHLKEHVRNHTGEKPYECTQCGKAFRWKSNFNLH-KKNHMVEKTYECKECGKSFSDLLSRRK 408
Cdd:COG5048  194 TSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPsSLSSSDSSSSASESPRSSLPTASSQSS 273

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568959401 409 H-----MRIHIVK-KPVECHQCGKTFRNQSILKTHMNS--HTGE--RPYGCD--LCGKAFSASSNLTAHRKIHTQERHYE 476
Cdd:COG5048  274 SpnesdSSSEKGFsLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPysLCGKLFSRNDALKRHILLHTSISPAK 353

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568959401 477 CTSC-------GKVFGDYLSRRRHMSIHLVKKRVDC--RQCGKAFRNQSTLKTHMRSHTGEKPYECD--HCGKAFSIGSN 545
Cdd:COG5048  354 EKLLnssskfsPLLNNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYN 433

                        410       420
                 ....*....|....*....|....*
gi 568959401 546 LNVHRRIHTGEKPYECLICGKAFSD 570
Cdd:COG5048  434 LIPHKKIHTNHAPLLCSILKSFRRD 458
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
60-118 6.60e-29

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 109.22  E-value: 6.60e-29
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 568959401    60 VTFQDIAVDFTEKEWPLLDSSQRKLYKDVMLENYSNLSSLGYQVGKPRLISHLEQEEDL 118
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEP 59
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 59-100 8.86e-23

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 90.99  E-value: 8.86e-23
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 568959401   59 SVTFQDIAVDFTEKEWPLLDSSQRKLYKDVMLENYSNLSSLG 100
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 60-99 1.65e-17

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 76.05  E-value: 1.65e-17
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 568959401  60 VTFQDIAVDFTEKEWPLLDSSQRKLYKDVMLENYSNLSSL 99
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
223-570 6.95e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.55  E-value: 6.95e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568959401 223 HKCHQCQKAFTTSASLTRHHRIHTGEKPYECS--SCGKAFNDPSALRSHTRTHLKE------------------------ 276
Cdd:COG5048   34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNpsdlnskslplsnskasssslsss 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568959401 277 -----KPFDCSQCSNAFRTLSALKIHMRVHTGERPYKCDECGKAYGRS----------------------CHLIAHKRTH 329
Cdd:COG5048  114 ssnsnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTpqsnslhpplpanslskdpssnLSLLISSNVS 193

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568959401 330 TGERPYECQDCGKAFQHPSHLKEHVRNHTGEKPYECTQCGKAFRWKSNFNLH-KKNHMVEKTYECKECGKSFSDLLSRRK 408
Cdd:COG5048  194 TSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPsSLSSSDSSSSASESPRSSLPTASSQSS 273

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568959401 409 H-----MRIHIVK-KPVECHQCGKTFRNQSILKTHMNS--HTGE--RPYGCD--LCGKAFSASSNLTAHRKIHTQERHYE 476
Cdd:COG5048  274 SpnesdSSSEKGFsLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPysLCGKLFSRNDALKRHILLHTSISPAK 353

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568959401 477 CTSC-------GKVFGDYLSRRRHMSIHLVKKRVDC--RQCGKAFRNQSTLKTHMRSHTGEKPYECD--HCGKAFSIGSN 545
Cdd:COG5048  354 EKLLnssskfsPLLNNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYN 433

                        410       420
                 ....*....|....*....|....*
gi 568959401 546 LNVHRRIHTGEKPYECLICGKAFSD 570
Cdd:COG5048  434 LIPHKKIHTNHAPLLCSILKSFRRD 458
zf-H2C2_2 pfam13465
Zinc-finger double domain;
518-541 6.41e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.05  E-value: 6.41e-05
                          10        20
                  ....*....|....*....|....
gi 568959401  518 LKTHMRSHTGEKPYECDHCGKAFS 541
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 249-301 8.23e-04

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 38.69  E-value: 8.23e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 568959401 249 KPYeCSSCGKAFNDPSALRSHtrthLKEKPFDCSQCSNAFRTLSALKIH-MRVH 301
Cdd:cd20908    1 KPW-CYYCDREFDDEKILIQH----QKAKHFKCHICHKKLYTAGGLAVHcLQVH 49
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
60-118 6.60e-29

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 109.22  E-value: 6.60e-29
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 568959401    60 VTFQDIAVDFTEKEWPLLDSSQRKLYKDVMLENYSNLSSLGYQVGKPRLISHLEQEEDL 118
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEP 59
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 59-100 8.86e-23

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 90.99  E-value: 8.86e-23
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 568959401   59 SVTFQDIAVDFTEKEWPLLDSSQRKLYKDVMLENYSNLSSLG 100
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 60-99 1.65e-17

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 76.05  E-value: 1.65e-17
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 568959401  60 VTFQDIAVDFTEKEWPLLDSSQRKLYKDVMLENYSNLSSL 99
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
223-570 6.95e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.55  E-value: 6.95e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568959401 223 HKCHQCQKAFTTSASLTRHHRIHTGEKPYECS--SCGKAFNDPSALRSHTRTHLKE------------------------ 276
Cdd:COG5048   34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNpsdlnskslplsnskasssslsss 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568959401 277 -----KPFDCSQCSNAFRTLSALKIHMRVHTGERPYKCDECGKAYGRS----------------------CHLIAHKRTH 329
Cdd:COG5048  114 ssnsnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTpqsnslhpplpanslskdpssnLSLLISSNVS 193

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568959401 330 TGERPYECQDCGKAFQHPSHLKEHVRNHTGEKPYECTQCGKAFRWKSNFNLH-KKNHMVEKTYECKECGKSFSDLLSRRK 408
Cdd:COG5048  194 TSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPsSLSSSDSSSSASESPRSSLPTASSQSS 273

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568959401 409 H-----MRIHIVK-KPVECHQCGKTFRNQSILKTHMNS--HTGE--RPYGCD--LCGKAFSASSNLTAHRKIHTQERHYE 476
Cdd:COG5048  274 SpnesdSSSEKGFsLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPysLCGKLFSRNDALKRHILLHTSISPAK 353

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568959401 477 CTSC-------GKVFGDYLSRRRHMSIHLVKKRVDC--RQCGKAFRNQSTLKTHMRSHTGEKPYECD--HCGKAFSIGSN 545
Cdd:COG5048  354 EKLLnssskfsPLLNNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYN 433

                        410       420
                 ....*....|....*....|....*
gi 568959401 546 LNVHRRIHTGEKPYECLICGKAFSD 570
Cdd:COG5048  434 LIPHKKIHTNHAPLLCSILKSFRRD 458
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
237-493 1.89e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.38  E-value: 1.89e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568959401 237 SLTRHHRIHTGEKPYECSSCGKAFNDPSALRSHTRTHLKEKPFDCSQCSNAFRTLSALKIHMRVHTGERPYKCDECGKAY 316
Cdd:COG5048  185 SLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSS 264

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568959401 317 G--RSCHLIAHKRTHTGER-----PYECQDCGKAFQHPSHLKEHVR--NHTGE--KPYECT--QCGKAFRWKSNFNLHKK 383
Cdd:COG5048  265 LptASSQSSSPNESDSSSEkgfslPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPysLCGKLFSRNDALKRHIL 344

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568959401 384 NHMVEKTYECK--ECGKSFSDLLSRRKHMRIHIVK-----KPVEC--HQCGKTFRNQSILKTHMNSHTGERPYGCD--LC 452
Cdd:COG5048  345 LHTSISPAKEKllNSSSKFSPLLNNEPPQSLQQYKdlkndKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPC 424

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 568959401 453 GKAFSASSNLTAHRKIHTQERHYECTSCGKVFGDYLSRRRH 493
Cdd:COG5048  425 SKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHG 465
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
249-564 4.99e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 46.23  E-value: 4.99e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568959401 249 KPYECSSCGKAFNDPSALRSHTRTHLKEKPFDCSQ--CSNAFRTLSALKIHMRVHTGERPYKC-DECGKAYGRSCHLIAH 325
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568959401 326 KRTHTGERPYECQDCGKAFQHPSHLKEHVRNHTGEKPYECTQCGKAFRWKSNFNLHKKNHMVEKTyeckecGKSFSDLLS 405
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSL------SKDPSSNLS 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568959401 406 RRKHMRIHIVKKPVECHQCGKTFRNQSILKTHMNSHTGERPYGCDLCGKAFSASSNLTAHRKIHTQERHYECTSCGKVFG 485
Cdd:COG5048  186 LLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSL 265

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568959401 486 DYLSRRRHMSIHL-------VKKRVDCRQCGKAFRNQSTLKTHMRS--HTGE--KPYECDH--CGKAFSIGSNLNVHRRI 552
Cdd:COG5048  266 PTASSQSSSPNESdsssekgFSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILL 345

                        330
                 ....*....|..
gi 568959401 553 HTGEKPYECLIC 564
Cdd:COG5048  346 HTSISPAKEKLL 357
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
305-586 5.45e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.84  E-value: 5.45e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568959401 305 RPYKCDECGKAYGRSCHLIAHKRTHTGERPYECQD--CGKAFQHPSHLKEHVRNHTGEKPYECT-QCGKAFRWKSNFNLH 381
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568959401 382 KKNHMVEKTYECKECGKSFSDLLSRRKHMRIHIVKKPVECHQC-GKTFRNQSILKTHMNSHTGErpygcdLCGKAFSASS 460
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLPANS------LSKDPSSNLS 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568959401 461 NLTAHRKIHTQERHYECTSCGKVFGDYLSRRRHMSIHLVkKRVDCRQCGKAF-------RNQSTLKTHMRSHTGE----- 528
Cdd:COG5048  186 LLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSS-SSLPLTTNSQLSpksllsqSPSSLSSSDSSSSASEsprss 264

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568959401 529 -----------------------KPYECDHCGKAFSIGSNLNVHRR--IHTGE--KPYEC--LICGKAFSDHSSLRSHVK 579
Cdd:COG5048  265 lptassqssspnesdsssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHIL 344


                 ....*..
gi 568959401 580 THRGRSS 586
Cdd:COG5048  345 LHTSISP 351
zf-H2C2_2 pfam13465
Zinc-finger double domain;
518-541 6.41e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.05  E-value: 6.41e-05
                          10        20
                  ....*....|....*....|....
gi 568959401  518 LKTHMRSHTGEKPYECDHCGKAFS 541
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
349-372 1.40e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.40e-04
                          10        20
                  ....*....|....*....|....
gi 568959401  349 HLKEHVRNHTGEKPYECTQCGKAF 372
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
237-261 5.83e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 5.83e-04
                          10        20
                  ....*....|....*....|....*
gi 568959401  237 SLTRHHRIHTGEKPYECSSCGKAFN 261
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
293-316 6.30e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 6.30e-04
                          10        20
                  ....*....|....*....|....
gi 568959401  293 ALKIHMRVHTGERPYKCDECGKAY 316
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 249-301 8.23e-04

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 38.69  E-value: 8.23e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 568959401 249 KPYeCSSCGKAFNDPSALRSHtrthLKEKPFDCSQCSNAFRTLSALKIH-MRVH 301
Cdd:cd20908    1 KPW-CYYCDREFDDEKILIQH----QKAKHFKCHICHKKLYTAGGLAVHcLQVH 49
zf-H2C2_2 pfam13465
Zinc-finger double domain;
545-569 1.33e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.33e-03
                          10        20
                  ....*....|....*....|....*
gi 568959401  545 NLNVHRRIHTGEKPYECLICGKAFS 569
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
321-344 2.92e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.92e-03
                          10        20
                  ....*....|....*....|....
gi 568959401  321 HLIAHKRTHTGERPYECQDCGKAF 344
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 508-579 7.24e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 39.32  E-value: 7.24e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568959401 508 CGKAFRNQSTLKTHMRShtgekpyecDHCGKAFSIGSNLNVHRRIHTGEKPYECLICGKAFSDHSSLRSHVK 579
Cdd:COG5189  357 CNKKYKNQNGLKYHMLH---------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKYHRK 419
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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