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Conserved domains on  [gi|568966781|ref|XP_006513336|]
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keratocan isoform X1 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK15370 super family cl33128
type III secretion system effector E3 ubiquitin transferase SlrP;
16-298 2.73e-20

type III secretion system effector E3 ubiquitin transferase SlrP;


The actual alignment was detected with superfamily member PRK15370:

Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 92.07  E-value: 2.73e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966781  16 DTVWTQSVRQAyeiqdPEDWDVHDDFYCPRECFCPPSFPTALYCENRGLTEIPP-IPSRIWYLYLENNLIESIPEkpfen 94
Cdd:PRK15370 147 ELIWSEWVKEA-----PAKEAANREEAVQRMRDCLKNNKTELRLKILGLTTIPAcIPEQITTLILDNNELKSLPE----- 216

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966781  95 atqlrwiNLNKNKITNYgiekgalsqlkkllflfLEDNELEEVPSPLPRSLEQLQLARNKVSRIPQGTFSNLENltlLDL 174
Cdd:PRK15370 217 -------NLQGNIKTLY-----------------ANSNQLTSIPATLPDTIQEMELSINRITELPERLPSALQS---LDL 269

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966781 175 QHNKLldNAFQRDTFKGLKNlmqLNMAKNALRNMPPRLPANTMQLFLDNNSIEGIPEnyfNVIPKVAFLRLNHNKLSD-- 252
Cdd:PRK15370 270 FHNKI--SCLPENLPEELRY---LSVYDNSIRTLPAHLPSGITHLNVQSNSLTALPE---TLPPGLKTLEAGENALTSlp 341

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 568966781 253 AGLPsrgfdvSSILDLQLSYNQLTNFPR-INANLQHLHLDHNKIKNV 298
Cdd:PRK15370 342 ASLP------PELQVLDVSKNQITVLPEtLPPTITTLDVSRNALTNL 382
LRR_8 super family cl38440
Leucine rich repeat;
268-331 8.10e-03

Leucine rich repeat;


The actual alignment was detected with superfamily member pfam13855:

Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 34.42  E-value: 8.10e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568966781  268 LQLSYNQLTNFPRI----NANLQHLHLDHNKIKNVNMsvicpttlraeqDAFIHGPQLSYLRLDGNEI 331
Cdd:pfam13855   6 LDLSNNRLTSLDDGafkgLSNLKVLDLSNNLLTTLSP------------GAFSGLPSLRYLDLSGNRL 61
 
Name Accession Description Interval E-value
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
16-298 2.73e-20

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 92.07  E-value: 2.73e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966781  16 DTVWTQSVRQAyeiqdPEDWDVHDDFYCPRECFCPPSFPTALYCENRGLTEIPP-IPSRIWYLYLENNLIESIPEkpfen 94
Cdd:PRK15370 147 ELIWSEWVKEA-----PAKEAANREEAVQRMRDCLKNNKTELRLKILGLTTIPAcIPEQITTLILDNNELKSLPE----- 216

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966781  95 atqlrwiNLNKNKITNYgiekgalsqlkkllflfLEDNELEEVPSPLPRSLEQLQLARNKVSRIPQGTFSNLENltlLDL 174
Cdd:PRK15370 217 -------NLQGNIKTLY-----------------ANSNQLTSIPATLPDTIQEMELSINRITELPERLPSALQS---LDL 269

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966781 175 QHNKLldNAFQRDTFKGLKNlmqLNMAKNALRNMPPRLPANTMQLFLDNNSIEGIPEnyfNVIPKVAFLRLNHNKLSD-- 252
Cdd:PRK15370 270 FHNKI--SCLPENLPEELRY---LSVYDNSIRTLPAHLPSGITHLNVQSNSLTALPE---TLPPGLKTLEAGENALTSlp 341

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 568966781 253 AGLPsrgfdvSSILDLQLSYNQLTNFPR-INANLQHLHLDHNKIKNV 298
Cdd:PRK15370 342 ASLP------PELQVLDVSKNQITVLPEtLPPTITTLDVSRNALTNL 382
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
90-303 5.37e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 72.66  E-value: 5.37e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966781  90 KPFENATQLRWINLNKNKITNYGIEKGALSQlkkllflfledneleevpsplprsLEQLQLARNKVSRIPQgTFSNLENL 169
Cdd:COG4886  107 EELSNLTNLESLDLSGNQLTDLPEELANLTN------------------------LKELDLSNNQLTDLPE-PLGNLTNL 161

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966781 170 TLLDLQHNKLLDnafQRDTFKGLKNLMQLNMAKNALRNMPPRLPANTM--QLFLDNNSIEGIPENYFNvIPKVAFLRLNH 247
Cdd:COG4886  162 KSLDLSNNQLTD---LPEELGNLTNLKELDLSNNQITDLPEPLGNLTNleELDLSGNQLTDLPEPLAN-LTNLETLDLSN 237

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 568966781 248 NKLSDagLPSRGfDVSSILDLQLSYNQLTNFPRI--NANLQHLHLDHNKIKNVNMSVI 303
Cdd:COG4886  238 NQLTD--LPELG-NLTNLEELDLSNNQLTDLPPLanLTNLKTLDLSNNQLTDLKLKEL 292
LRR_8 pfam13855
Leucine rich repeat;
143-205 4.84e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.06  E-value: 4.84e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568966781  143 RSLEQLQLARNKVSRIPQGTFSNLENLTLLDLQHNKLldNAFQRDTFKGLKNLMQLNMAKNAL 205
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLL--TTLSPGAFSGLPSLRYLDLSGNRL 61
LRRNT smart00013
Leucine rich repeat N-terminal domain;
43-76 2.17e-06

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 43.85  E-value: 2.17e-06
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 568966781    43 CPRECFCPPsfpTALYCENRGLTEIPP-IPSRIWY 76
Cdd:smart00013   2 CPAPCNCSG---TAVDCSGRGLTEVPLdLPPDTTL 33
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 142-332 3.04e-06

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 48.51  E-value: 3.04e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966781 142 PRSLEQLQLARNKVSRIPQGT------FSNLENLTLLDLQhnkllDNAFQRDTFKGLKNLMQ------LNMAKNALRNMP 209
Cdd:cd00116   50 QPSLKELCLSLNETGRIPRGLqsllqgLTKGCGLQELDLS-----DNALGPDGCGVLESLLRssslqeLKLNNNGLGDRG 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966781 210 PRLPANTMQ--------LFLDNNSIEGIP----ENYFNVIPKVAFLRLNHNKLSDAGLPS--RGFDVSSILD-LQLSYNQ 274
Cdd:cd00116  125 LRLLAKGLKdlppalekLVLGRNRLEGAScealAKALRANRDLKELNLANNGIGDAGIRAlaEGLKANCNLEvLDLNNNG 204

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568966781 275 LTN--------FPRINANLQHLHLDHNKIKNVNMSVICpttlraeqDAFIHG-PQLSYLRLDGNEIK 332
Cdd:cd00116  205 LTDegasalaeTLASLKSLEVLNLGDNNLTDAGAAALA--------SALLSPnISLLTLSLSCNDIT 263
LRR_8 pfam13855
Leucine rich repeat;
268-331 8.10e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 34.42  E-value: 8.10e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568966781  268 LQLSYNQLTNFPRI----NANLQHLHLDHNKIKNVNMsvicpttlraeqDAFIHGPQLSYLRLDGNEI 331
Cdd:pfam13855   6 LDLSNNRLTSLDDGafkgLSNLKVLDLSNNLLTTLSP------------GAFSGLPSLRYLDLSGNRL 61
 
Name Accession Description Interval E-value
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
16-298 2.73e-20

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 92.07  E-value: 2.73e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966781  16 DTVWTQSVRQAyeiqdPEDWDVHDDFYCPRECFCPPSFPTALYCENRGLTEIPP-IPSRIWYLYLENNLIESIPEkpfen 94
Cdd:PRK15370 147 ELIWSEWVKEA-----PAKEAANREEAVQRMRDCLKNNKTELRLKILGLTTIPAcIPEQITTLILDNNELKSLPE----- 216

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966781  95 atqlrwiNLNKNKITNYgiekgalsqlkkllflfLEDNELEEVPSPLPRSLEQLQLARNKVSRIPQGTFSNLENltlLDL 174
Cdd:PRK15370 217 -------NLQGNIKTLY-----------------ANSNQLTSIPATLPDTIQEMELSINRITELPERLPSALQS---LDL 269

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966781 175 QHNKLldNAFQRDTFKGLKNlmqLNMAKNALRNMPPRLPANTMQLFLDNNSIEGIPEnyfNVIPKVAFLRLNHNKLSD-- 252
Cdd:PRK15370 270 FHNKI--SCLPENLPEELRY---LSVYDNSIRTLPAHLPSGITHLNVQSNSLTALPE---TLPPGLKTLEAGENALTSlp 341

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 568966781 253 AGLPsrgfdvSSILDLQLSYNQLTNFPR-INANLQHLHLDHNKIKNV 298
Cdd:PRK15370 342 ASLP------PELQVLDVSKNQITVLPEtLPPTITTLDVSRNALTNL 382
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
90-303 5.37e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 72.66  E-value: 5.37e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966781  90 KPFENATQLRWINLNKNKITNYGIEKGALSQlkkllflfledneleevpsplprsLEQLQLARNKVSRIPQgTFSNLENL 169
Cdd:COG4886  107 EELSNLTNLESLDLSGNQLTDLPEELANLTN------------------------LKELDLSNNQLTDLPE-PLGNLTNL 161

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966781 170 TLLDLQHNKLLDnafQRDTFKGLKNLMQLNMAKNALRNMPPRLPANTM--QLFLDNNSIEGIPENYFNvIPKVAFLRLNH 247
Cdd:COG4886  162 KSLDLSNNQLTD---LPEELGNLTNLKELDLSNNQITDLPEPLGNLTNleELDLSGNQLTDLPEPLAN-LTNLETLDLSN 237

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 568966781 248 NKLSDagLPSRGfDVSSILDLQLSYNQLTNFPRI--NANLQHLHLDHNKIKNVNMSVI 303
Cdd:COG4886  238 NQLTD--LPELG-NLTNLEELDLSNNQLTDLPPLanLTNLKTLDLSNNQLTDLKLKEL 292
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
55-315 1.81e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 68.04  E-value: 1.81e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966781  55 TALYCENRGLTEIP-PIPS--RIWYLYLENNLIESIPEkPFENATQLRWINLNKNKITNYGIEkgaLSQLKKLLFLFLED 131
Cdd:COG4886  139 KELDLSNNQLTDLPePLGNltNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDLPEP---LGNLTNLEELDLSG 214

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966781 132 NELEEVPSPLPR--SLEQLQLARNKVSRIPQgtFSNLENLTLLDLQHNKLLDnafqRDTFKGLKNLMQLNMAKNALRNMP 209
Cdd:COG4886  215 NQLTDLPEPLANltNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTD----LPPLANLTNLKTLDLSNNQLTDLK 288

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966781 210 PRLPANTMQLFLDNNSIEGIPENYFNVIPKVAFLRLNHNKLSDAGLPSRGFDVSSILDLQLSYNQLTNFPRINANLQHLH 289
Cdd:COG4886  289 LKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLT 368

                        250       260
                 ....*....|....*....|....*.
gi 568966781 290 LDHNKIKNVNMSVICPTTLRAEQDAF 315
Cdd:COG4886  369 LGLLGLLEATLLTLALLLLTLLLLLL 394
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 139-346 1.49e-10

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 62.56  E-value: 1.49e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966781 139 SPLPRsLEQLQLARNKVS-RIPQgTFSNLENLTLLDLQHNKLLDNAfqRDTFKGLKNLMQLNMAKNALRN-MPPRLPA-- 214
Cdd:PLN00113 329 TSLPR-LQVLQLWSNKFSgEIPK-NLGKHNNLTVLDLSTNNLTGEI--PEGLCSSGNLFKLILFSNSLEGeIPKSLGAcr 404

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966781 215 NTMQLFLDNNSIEGIPENYFNVIPKVAFLRLNHNKLSdAGLPSRGFDVSSILDLQLSYNQLT-NFPRI--NANLQHLHLD 291
Cdd:PLN00113 405 SLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQ-GRINSRKWDMPSLQMLSLARNKFFgGLPDSfgSKRLENLDLS 483

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 568966781 292 HNKIknvnmSVICPTTLRAEqdafihgPQLSYLRLDGNEIKPPIPIDLVACFKLL 346
Cdd:PLN00113 484 RNQF-----SGAVPRKLGSL-------SELMQLKLSENKLSGEIPDELSSCKKLV 526
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
162-332 5.51e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 60.33  E-value: 5.51e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966781 162 TFSNLENLTLLDLQHNKLLDNafqrdtfkgLKNLMQLNMAKNALRNMPPRLPANTM--QLFLDNNSIEGIPENYFNvIPK 239
Cdd:COG4886   91 DLGDLTNLTELDLSGNEELSN---------LTNLESLDLSGNQLTDLPEELANLTNlkELDLSNNQLTDLPEPLGN-LTN 160

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966781 240 VAFLRLNHNKLSDagLPSRGFDVSSILDLQLSYNQLTNFPRI---NANLQHLHLDHNKIKNVNMSVicpTTLraeqdafi 316
Cdd:COG4886  161 LKSLDLSNNQLTD--LPEELGNLTNLKELDLSNNQITDLPEPlgnLTNLEELDLSGNQLTDLPEPL---ANL-------- 227

                        170
                 ....*....|....*.
gi 568966781 317 hgPQLSYLRLDGNEIK 332
Cdd:COG4886  228 --TNLETLDLSNNQLT 241
LRR_8 pfam13855
Leucine rich repeat;
143-205 4.84e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.06  E-value: 4.84e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568966781  143 RSLEQLQLARNKVSRIPQGTFSNLENLTLLDLQHNKLldNAFQRDTFKGLKNLMQLNMAKNAL 205
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLL--TTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 132-290 4.78e-07

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 51.77  E-value: 4.78e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966781 132 NELE-EVPSPLP--RSLEQLQLARNKVS-RIPQGtFSNLENLTLLDLQHNKLLDN--------------AFQRDTFKG-- 191
Cdd:PLN00113 390 NSLEgEIPKSLGacRSLRRVRLQDNSFSgELPSE-FTKLPLVYFLDISNNNLQGRinsrkwdmpslqmlSLARNKFFGgl 468

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966781 192 -----LKNLMQLNMAKNALRNMPPR----LPaNTMQLFLDNNSIEGIPENYFNVIPKVAFLRLNHNKLSdAGLPSRGFDV 262
Cdd:PLN00113 469 pdsfgSKRLENLDLSRNQFSGAVPRklgsLS-ELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLS-GQIPASFSEM 546

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 568966781 263 SSILDLQLSYNQL-----TNFPRINA----NLQHLHL 290
Cdd:PLN00113 547 PVLSQLDLSQNQLsgeipKNLGNVESlvqvNISHNHL 583
LRRNT smart00013
Leucine rich repeat N-terminal domain;
43-76 2.17e-06

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 43.85  E-value: 2.17e-06
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 568966781    43 CPRECFCPPsfpTALYCENRGLTEIPP-IPSRIWY 76
Cdd:smart00013   2 CPAPCNCSG---TAVDCSGRGLTEVPLdLPPDTTL 33
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 142-332 3.04e-06

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 48.51  E-value: 3.04e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966781 142 PRSLEQLQLARNKVSRIPQGT------FSNLENLTLLDLQhnkllDNAFQRDTFKGLKNLMQ------LNMAKNALRNMP 209
Cdd:cd00116   50 QPSLKELCLSLNETGRIPRGLqsllqgLTKGCGLQELDLS-----DNALGPDGCGVLESLLRssslqeLKLNNNGLGDRG 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966781 210 PRLPANTMQ--------LFLDNNSIEGIP----ENYFNVIPKVAFLRLNHNKLSDAGLPS--RGFDVSSILD-LQLSYNQ 274
Cdd:cd00116  125 LRLLAKGLKdlppalekLVLGRNRLEGAScealAKALRANRDLKELNLANNGIGDAGIRAlaEGLKANCNLEvLDLNNNG 204

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568966781 275 LTN--------FPRINANLQHLHLDHNKIKNVNMSVICpttlraeqDAFIHG-PQLSYLRLDGNEIK 332
Cdd:cd00116  205 LTDegasalaeTLASLKSLEVLNLGDNNLTDAGAAALA--------SALLSPnISLLTLSLSCNDIT 263
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
49-322 1.34e-05

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 47.08  E-value: 1.34e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966781  49 CPPSFPTALYCENRGLTEIPPIPSRIWYLYLENNLIESIPEKPfenaTQLRWINLNKNKITNYGIEKGALSQLKKLlflf 128
Cdd:PRK15387 219 CLPAHITTLVIPDNNLTSLPALPPELRTLEVSGNQLTSLPVLP----PGLLELSIFSNPLTHLPALPSGLCKLWIF---- 290

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966781 129 leDNELEEVPSpLPRSLEQLQLARNKVSRIPQgtfsnlenltlLDLQHNKLLDNAFQRDTFKGLKN-LMQLNMAKNALRN 207
Cdd:PRK15387 291 --GNQLTSLPV-LPPGLQELSVSDNQLASLPA-----------LPSELCKLWAYNNQLTSLPTLPSgLQELSVSDNQLAS 356

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966781 208 MPPrLPANTMQLFLDNNSIEGIPenyfnVIPK-VAFLRLNHNKLSDAG-LPSRgfdvssILDLQLSYNQLTNFPRINANL 285
Cdd:PRK15387 357 LPT-LPSELYKLWAYNNRLTSLP-----ALPSgLKELIVSGNRLTSLPvLPSE------LKELMVSGNRLTSLPMLPSGL 424

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 568966781 286 QHLHLDHNKIKNVNMSVIcptTLRAEQDAFIHGPQLS 322
Cdd:PRK15387 425 LSLSVYRNQLTRLPESLI---HLSSETTVNLEGNPLS 458
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 55-231 6.35e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 43.62  E-value: 6.35e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966781  55 TALYCENRGLTEIPPIPS--RIWYLYLENNLIESIPekPFENATQLRWINLNKNKITnygiekgalsqlkkllflfledn 132
Cdd:cd21340    5 THLYLNDKNITKIDNLSLckNLKVLYLYDNKITKIE--NLEFLTNLTHLYLQNNQIE----------------------- 59

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966781 133 ELEEVpSPLPRsLEQLQLARNKVSRIpQGtFSNLENLTLLDLQHNKLLDN---AFQRDTFKGL-KNLMQLNMAKNALRNM 208
Cdd:cd21340   60 KIENL-ENLVN-LKKLYLGGNRISVV-EG-LENLTNLEELHIENQRLPPGeklTFDPRSLAALsNSLRVLNISGNNIDSL 135

                        170       180
                 ....*....|....*....|....
gi 568966781 209 PPRLP-ANTMQLFLDNNSIEGIPE 231
Cdd:cd21340  136 EPLAPlRNLEQLDASNNQISDLEE 159
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 81-339 8.26e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 44.45  E-value: 8.26e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966781  81 NNLIESIPEKPFENATQLRWINLNKNKITNyGIEKGALSqlkkllflfledneleevpsplprSLEQLQLARNKVS-RIP 159
Cdd:PLN00113 103 NQLSGPIPDDIFTTSSSLRYLNLSNNNFTG-SIPRGSIP------------------------NLETLDLSNNMLSgEIP 157

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966781 160 Q--GTFSNLEnltLLDLQHNKLLDNAfqRDTFKGLKNLMQLNMAKNALRNMPPR---------------------LPANT 216
Cdd:PLN00113 158 NdiGSFSSLK---VLDLGGNVLVGKI--PNSLTNLTSLEFLTLASNQLVGQIPRelgqmkslkwiylgynnlsgeIPYEI 232

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966781 217 MQL----FLD---NNSIEGIPENYFNvIPKVAFLRLNHNKLSDAgLPSRGFDVSSILDLQLSYNQLT-NFPRINANLQHL 288
Cdd:PLN00113 233 GGLtslnHLDlvyNNLTGPIPSSLGN-LKNLQYLFLYQNKLSGP-IPPSIFSLQKLISLDLSDNSLSgEIPELVIQLQNL 310

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 568966781 289 HLDHnkIKNVNMSVICPTTLRAEqdafihgPQLSYLRLDGNEIKPPIPIDL 339
Cdd:PLN00113 311 EILH--LFSNNFTGKIPVALTSL-------PRLQVLQLWSNKFSGEIPKNL 352
LRR_8 pfam13855
Leucine rich repeat;
168-226 9.01e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.82  E-value: 9.01e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568966781  168 NLTLLDLQHNKLLDnaFQRDTFKGLKNLMQLNMAKNALRNMPPR----LPANTMqLFLDNNSI 226
Cdd:pfam13855   2 NLRSLDLSNNRLTS--LDDGAFKGLSNLKVLDLSNNLLTTLSPGafsgLPSLRY-LDLSGNRL 61
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 42-71 1.09e-04

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 38.76  E-value: 1.09e-04
                          10        20        30
                  ....*....|....*....|....*....|.
gi 568966781   42 YCPRECFCPPsfpTALYCENRGLTEIPP-IP 71
Cdd:pfam01462   1 ACPVPCHCSA---TVVNCSDRGLTAVPRdLP 28
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
51-185 6.50e-04

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 41.69  E-value: 6.50e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966781  51 PSFPT---ALYCENRGLTEIPPIPSRIWYLYLENNLIESIPEKPFE----------------NATQLRWINLNKNKITNY 111
Cdd:PRK15387 318 PALPSelcKLWAYNNQLTSLPTLPSGLQELSVSDNQLASLPTLPSElyklwaynnrltslpaLPSGLKELIVSGNRLTSL 397

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568966781 112 GIEKGALSQlkkllfLFLEDNELEEVPSpLPRSLEQLQLARNKVSRIPQgTFSNLENLTLLDLQHNKLLDNAFQ 185
Cdd:PRK15387 398 PVLPSELKE------LMVSGNRLTSLPM-LPSGLLSLSVYRNQLTRLPE-SLIHLSSETTVNLEGNPLSERTLQ 463
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
51-160 1.40e-03

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 40.45  E-value: 1.40e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966781  51 PSFPTALYCENRGLTEIPP-IPSRIWYLYLENNLIESIPEK-PFEnatqLRWINLNKNKITnygiekgALSQLK--KLLF 126
Cdd:PRK15370 303 PSGITHLNVQSNSLTALPEtLPPGLKTLEAGENALTSLPASlPPE----LQVLDVSKNQIT-------VLPETLppTITT 371

                         90       100       110
                 ....*....|....*....|....*....|....
gi 568966781 127 LFLEDNELEEVPSPLPRSLEQLQLARNKVSRIPQ 160
Cdd:PRK15370 372 LDVSRNALTNLPENLPAALQIMQASRNNLVRLPE 405
LRR_8 pfam13855
Leucine rich repeat;
76-179 1.64e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 36.35  E-value: 1.64e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966781   76 YLYLENNLIESIPEKPFENATQLRWINLNKNKITnygiekgalsqlkkllflfledneleevpsplprsleqlqlarnkv 155
Cdd:pfam13855   5 SLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLT---------------------------------------------- 38

                          90       100
                  ....*....|....*....|....
gi 568966781  156 sRIPQGTFSNLENLTLLDLQHNKL 179
Cdd:pfam13855  39 -TLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 143-331 6.59e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 37.46  E-value: 6.59e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966781 143 RSLEQLQLARNKVSRIPQgtFSNLENLTLLDLQHNKL--LDNafqrdtFKGLKNLmqlnmaknalrnmpprlpantMQLF 220
Cdd:cd21340   24 KNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIekIEN------LENLVNL---------------------KKLY 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966781 221 LDNNSI---EGIpENyfnvIPKVAFLRLNHNKLsDAGLPSRgFDVSSILDLQ-------LSYNQLTNfprIN-----ANL 285
Cdd:cd21340   75 LGGNRIsvvEGL-EN----LTNLEELHIENQRL-PPGEKLT-FDPRSLAALSnslrvlnISGNNIDS---LEplaplRNL 144

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 568966781 286 QHLHLDHNKIKnvNMSVICpttlraeqDAFIHGPQLSYLRLDGNEI 331
Cdd:cd21340  145 EQLDASNNQIS--DLEELL--------DLLSSWPSLRELDLTGNPV 180
LRR_8 pfam13855
Leucine rich repeat;
268-331 8.10e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 34.42  E-value: 8.10e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568966781  268 LQLSYNQLTNFPRI----NANLQHLHLDHNKIKNVNMsvicpttlraeqDAFIHGPQLSYLRLDGNEI 331
Cdd:pfam13855   6 LDLSNNRLTSLDDGafkgLSNLKVLDLSNNLLTTLSP------------GAFSGLPSLRYLDLSGNRL 61
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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