|
Name |
Accession |
Description |
Interval |
E-value |
| FN3 |
COG3401 |
Fibronectin type 3 domain [General function prediction only]; |
1009-1626 |
5.77e-16 |
|
Fibronectin type 3 domain [General function prediction only];
:
Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 83.90 E-value: 5.77e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 1009 NVTVSARIYKLAVFSYYTFWLTASTLVGNGNKSSDVIHVYTDQDIPEGGVGNLTYESLSSTAINVSWTPPSQPNGLVFYY 1088
Cdd:COG3401 4 SYLTSLDAGIAASAAANTAVNALSKAGGSGKTILVYLAVVLSVTTKESPGTLLVAAGLSSGGGLGTGGRAGTTSGVAAVA 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 1089 VSLnlqqSPPRHRRPPLTTYENSIYFDNLEKYTDYIFKITPStekGFSETYTAQLHIKTEEDVPDTPPIINTFKNLSSTS 1168
Cdd:COG3401 84 VAA----APPTATGLTTLTGSGSVGGATNTGLTSSDEVPSPA---VGTATTATAVAGGAATAGTYALGAGLYGVDGANAS 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 1169 ILLSWDPPLKPNGAILSYHLTLQGTHANRTFVTSGNHIVLEELSPFTLYSFLAAARTMKGLGPSSILFFYTDESAPLAPP 1248
Cdd:COG3401 157 GTTASSVAGAGVVVSPDTSATAAVATTSLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAP 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 1249 QNLTLINYTSDFVWLTWSPSPLPGgivkVYSFKIHEHETDTVFYKNISGFQ----TDAklaGLEPVSTYSISVSAFTKVG 1324
Cdd:COG3401 237 TGLTATADTPGSVTLSWDPVTESD----ATGYRVYRSNSGDGPFTKVATVTttsyTDT---GLTNGTTYYYRVTAVDAAG 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 1325 NGNQFSNVVKFTTQESVPDAVQNIACVARDWQSVSVMWDPP--RKANGIIIHYMITVEGNSTKV--SPRDPMYTFTKLLA 1400
Cdd:COG3401 310 NESAPSNVVSVTTDLTPPAAPSGLTATAVGSSSITLSWTASsdADVTGYNVYRSTSGGGTYTKIaeTVTTTSYTDTGLTP 389
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 1401 NTSYIFEVRASTSAGEGNESQCNVSTLPETVP-------SVPTNTAFSNVQSTSVTLRWIKPDTILGYFQNYKITTqlra 1473
Cdd:COG3401 390 GTTYYYKVTAVDAAGNESAPSEEVSATTASAAsgesltaSVDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTG---- 465
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 1474 qkcrewepeecvehqevqYLYEANQTEDTVRGLKKFQWYRFQVAASTNAGYGNASSWISTQTLPGPPDGPPENVRVVATS 1553
Cdd:COG3401 466 ------------------NAVPFTTTSSTVTATTTDTTTANLSVTTGSLVGGSGASSVTNSVSVIGASAAAAVGGAPDGT 527
|
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568967537 1554 PFGINISWNEPAIITGPTFYLIDVKSVDNDNFNISFVKSNEENKTTEINDLEVFTRYSVVITAFVGNVSGAYT 1626
Cdd:COG3401 528 PNVTGASPVTVGASTGDVLITDLVSLTTSASSSVSGAGLGSGNLYLITTLGGSLLTTTSTNTNDVAGVHGGTL 600
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
668-747 |
1.02e-15 |
|
Fibronectin type III domain;
:
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 73.99 E-value: 1.02e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 668 SSPQDVKVTDVSPSELSLTWSPPEKPNGIIIAYEVFYQNADALFVKNT-----STTNITLSDLKPYTLYNISIQSYTRLG 742
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSGEPWNEitvpgTTTSVTLTGLKPGTEYEVRVQAVNGGG 80
|
....*
gi 568967537 743 HGNQS 747
Cdd:pfam00041 81 EGPPS 85
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
57-151 |
3.16e-15 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
:
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 72.91 E-value: 3.16e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 57 PGPPVFLAGERVGSAGILLSWNTPPNPNGRIISYVVKYKEVCPWMQTAYTRVRakPDSLEVLLTNLNPGTTYEIKVAAEN 136
Cdd:cd00063 1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVTP--GSETSYTLTGLKPGTEYEFRVRAVN 78
|
90
....*....|....*
gi 568967537 137 SAGIGVFSDPFLFQT 151
Cdd:cd00063 79 GGGESPPSESVTVTT 93
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
570-654 |
3.64e-14 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
:
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 69.83 E-value: 3.64e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 570 PSSIQIINYKNISSSSILLYWDPPEYPNGKITHYTIYAMELDTNRAFQMTTV---DNSFLITGLKKYTRYKMRVAASTHV 646
Cdd:cd00063 1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVTpgsETSYTLTGLKPGTEYEFRVRAVNGG 80
|
....*...
gi 568967537 647 GESSLSEE 654
Cdd:cd00063 81 GESPPSES 88
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
762-850 |
2.29e-12 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
:
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 64.83 E-value: 2.29e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 762 SAPENITYKNISSEEIEIFFLPPRSPNGIIQKYTIYLKRSNSHEARTIET---TSLTLTIGGLKKYTHYVIEVSASTLKG 838
Cdd:cd00063 2 SPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVtpgSETSYTLTGLKPGTEYEFRVRAVNGGG 81
|
90
....*....|..
gi 568967537 839 EGVRSMPISILT 850
Cdd:cd00063 82 ESPPSESVTVTT 93
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
857-934 |
1.19e-10 |
|
Fibronectin type III domain;
:
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 59.74 E-value: 1.19e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 857 SPPQNFSVKQLSGVTVMLSWQPPLEPNGIILYYTVYVWDKVSLK-----TINATEVSLELSDLDYHADYSAYVTASTRFG 931
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSGEpwneiTVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80
|
...
gi 568967537 932 DGK 934
Cdd:pfam00041 81 EGP 83
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
951-1049 |
5.68e-09 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
:
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 55.20 E-value: 5.68e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 951 DPPKDVHYVNLSSSSIILFWTPPVKPNGIIQYYSVYYQNTSSTFVQnftllEVTQEPGNVTvSARIYKLAVFSYYTFWLT 1030
Cdd:cd00063 2 SPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWK-----EVEVTPGSET-SYTLTGLKPGTEYEFRVR 75
|
90
....*....|....*....
gi 568967537 1031 ASTLVGNGnKSSDVIHVYT 1049
Cdd:cd00063 76 AVNGGGES-PPSESVTVTT 93
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
308-393 |
4.81e-08 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
:
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 52.50 E-value: 4.81e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 308 GPPQNCITGNVTGKAFSISWDPPAIVTGKF-SYRVELY----GPTGRILDNSTKDLRFVFTHLTPFTMYDVYVAAETSAG 382
Cdd:cd00063 2 SPPTNLRVTDVTSTSVTLSWTPPEDDGGPItGYVVEYRekgsGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81
|
90
....*....|.
gi 568967537 383 VGPKSNLSVFT 393
Cdd:cd00063 82 ESPPSESVTVT 92
|
|
| UP_III_II super family |
cl06408 |
Uroplakin IIIb, IIIa and II; Uroplakins (UPs) are a family of proteins that associate with ... |
1766-1928 |
5.00e-08 |
|
Uroplakin IIIb, IIIa and II; Uroplakins (UPs) are a family of proteins that associate with each other to form plaques on the apical surface of the urothelium, the pseudo-stratified epithelium lining the urinary tract from renal pelvis to the bladder outlet. UPs are classified into 3 types: UPIa and UPIb, UPII, and UPIIIa and IIIb. UPIs are tetraspanins that have four transmembrane domains separating one large and one small extracellular domain while UPII and UPIIIs are single-pass transmembrane proteins. UPIa and UPIb form specific heterodimers with UPII and UPIII, respectively, which allows them to exit the endoplasmatic rediculum. UPII/UPIa and UPIIIs/UPIb form heterotetramers; six of these tetramers form the 16nm particle, seen in the hexagonal array of the asymmetric unit membrane, which is believed to form a urinary tract barrier. Uroplakins are also believed to play a role during urinary tract morphogenesis.
The actual alignment was detected with superfamily member cd09968:
Pssm-ID: 471435 Cd Length: 187 Bit Score: 55.08 E-value: 5.00e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 1766 VTSTTITIRMPICYYNDDHGPIRNVQVLVAEAGAQQ----DGNVTKWYDAY--FNKARPYFTNEG-FPNPPCiegkTKFS 1838
Cdd:cd09968 18 PTSTTFTLEQPRCVFDSSASDTDDVWLVVAVSNATNnfnaPQNSTDPISTYsqFSGGQYYLTLRAsRDLYPC----GNPS 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 1839 GNEEIYVIGADNACmipgNEEKICNGPLKPKKQYLFKFRATNVMGQFTDSEYSDPIkTLGEGLSERTVE----------I 1908
Cdd:cd09968 94 LNAYVLRVGADGNC----TDNGNCNGPLPGPGPYRVKYLVMNGSGVVAQTNWSDPI-RLNQAKSYQTIDtwpgrrsggmI 168
|
170 180
....*....|....*....|
gi 568967537 1909 ILSVTLCILSIILLGtAIFA 1928
Cdd:cd09968 169 VITSILSVLLALLLL-ALLA 187
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
1645-1734 |
4.67e-06 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
:
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 46.72 E-value: 4.67e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 1645 DPPNNMTFQKIPDevTKFQLSFLPPSQPNGNIQVYQaLVYREDDPTAVQIHNLSIIqkTDTSVIamLEGLKGGHTYNISV 1724
Cdd:cd00063 2 SPPTNLRVTDVTS--TSVTLSWTPPEDDGGPITGYV-VEYREKGSGDWKEVEVTPG--SETSYT--LTGLKPGTEYEFRV 74
|
90
....*....|
gi 568967537 1725 YAINSAGAGP 1734
Cdd:cd00063 75 RAVNGGGESP 84
|
|
| FN3 super family |
cl27307 |
Fibronectin type 3 domain [General function prediction only]; |
76-441 |
2.94e-05 |
|
Fibronectin type 3 domain [General function prediction only];
The actual alignment was detected with superfamily member COG3401:
Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 49.23 E-value: 2.94e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 76 SWNTPPNPNGRIISYVVKYKEVCPWMQTAYTRVRAKPDSLEVLLTNLNPGTTYEIKVAAENSAGIGVFSDPFLFQTAESA 155
Cdd:COG3401 1 TGSSYLTSLDAGIAASAAANTAVNALSKAGGSGKTILVYLAVVLSVTTKESPGTLLVAAGLSSGGGLGTGGRAGTTSGVA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 156 PGKVVNLTVEALNYSAVNLIWYLPRQPNGKITSFKISVKHARSGIVVKDVSIKVEDLLSGKLPECNENSDSFLWSTTSPS 235
Cdd:COG3401 81 AVAVAAAPPTATGLTTLTGSGSVGGATNTGLTSSDEVPSPAVGTATTATAVAGGAATAGTYALGAGLYGVDGANASGTTA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 236 PTLSRATPPLRTTHLSNTLARNKISSVWKEPISFVVTHLRPYTTYLFEVSAVTTEAGYIDSTIVR-TPESVPEGPPQNCI 314
Cdd:COG3401 161 SSVAGAGVVVSPDTSATAAVATTSLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSvTTPTTPPSAPTGLT 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 315 TGNVTGKAFSISWDPPAI--VTGKFSYRVELYGPTGRILdNSTKDLRFVFTHLTPFTMYDVYVAAETSAGV-GPKSN-LS 390
Cdd:COG3401 241 ATADTPGSVTLSWDPVTEsdATGYRVYRSNSGDGPFTKV-ATVTTTSYTDTGLTNGTTYYYRVTAVDAAGNeSAPSNvVS 319
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 568967537 391 VFTPPDVPGAVFDLQIVEVEATEIRVSWRKPrqPNGIISQYRVKVSVLESG 441
Cdd:COG3401 320 VTTDLTPPAAPSGLTATAVGSSSITLSWTAS--SDADVTGYNVYRSTSGGG 368
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| FN3 |
COG3401 |
Fibronectin type 3 domain [General function prediction only]; |
1009-1626 |
5.77e-16 |
|
Fibronectin type 3 domain [General function prediction only];
Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 83.90 E-value: 5.77e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 1009 NVTVSARIYKLAVFSYYTFWLTASTLVGNGNKSSDVIHVYTDQDIPEGGVGNLTYESLSSTAINVSWTPPSQPNGLVFYY 1088
Cdd:COG3401 4 SYLTSLDAGIAASAAANTAVNALSKAGGSGKTILVYLAVVLSVTTKESPGTLLVAAGLSSGGGLGTGGRAGTTSGVAAVA 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 1089 VSLnlqqSPPRHRRPPLTTYENSIYFDNLEKYTDYIFKITPStekGFSETYTAQLHIKTEEDVPDTPPIINTFKNLSSTS 1168
Cdd:COG3401 84 VAA----APPTATGLTTLTGSGSVGGATNTGLTSSDEVPSPA---VGTATTATAVAGGAATAGTYALGAGLYGVDGANAS 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 1169 ILLSWDPPLKPNGAILSYHLTLQGTHANRTFVTSGNHIVLEELSPFTLYSFLAAARTMKGLGPSSILFFYTDESAPLAPP 1248
Cdd:COG3401 157 GTTASSVAGAGVVVSPDTSATAAVATTSLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAP 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 1249 QNLTLINYTSDFVWLTWSPSPLPGgivkVYSFKIHEHETDTVFYKNISGFQ----TDAklaGLEPVSTYSISVSAFTKVG 1324
Cdd:COG3401 237 TGLTATADTPGSVTLSWDPVTESD----ATGYRVYRSNSGDGPFTKVATVTttsyTDT---GLTNGTTYYYRVTAVDAAG 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 1325 NGNQFSNVVKFTTQESVPDAVQNIACVARDWQSVSVMWDPP--RKANGIIIHYMITVEGNSTKV--SPRDPMYTFTKLLA 1400
Cdd:COG3401 310 NESAPSNVVSVTTDLTPPAAPSGLTATAVGSSSITLSWTASsdADVTGYNVYRSTSGGGTYTKIaeTVTTTSYTDTGLTP 389
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 1401 NTSYIFEVRASTSAGEGNESQCNVSTLPETVP-------SVPTNTAFSNVQSTSVTLRWIKPDTILGYFQNYKITTqlra 1473
Cdd:COG3401 390 GTTYYYKVTAVDAAGNESAPSEEVSATTASAAsgesltaSVDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTG---- 465
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 1474 qkcrewepeecvehqevqYLYEANQTEDTVRGLKKFQWYRFQVAASTNAGYGNASSWISTQTLPGPPDGPPENVRVVATS 1553
Cdd:COG3401 466 ------------------NAVPFTTTSSTVTATTTDTTTANLSVTTGSLVGGSGASSVTNSVSVIGASAAAAVGGAPDGT 527
|
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568967537 1554 PFGINISWNEPAIITGPTFYLIDVKSVDNDNFNISFVKSNEENKTTEINDLEVFTRYSVVITAFVGNVSGAYT 1626
Cdd:COG3401 528 PNVTGASPVTVGASTGDVLITDLVSLTTSASSSVSGAGLGSGNLYLITTLGGSLLTTTSTNTNDVAGVHGGTL 600
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
668-747 |
1.02e-15 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 73.99 E-value: 1.02e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 668 SSPQDVKVTDVSPSELSLTWSPPEKPNGIIIAYEVFYQNADALFVKNT-----STTNITLSDLKPYTLYNISIQSYTRLG 742
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSGEPWNEitvpgTTTSVTLTGLKPGTEYEVRVQAVNGGG 80
|
....*
gi 568967537 743 HGNQS 747
Cdd:pfam00041 81 EGPPS 85
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
57-151 |
3.16e-15 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 72.91 E-value: 3.16e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 57 PGPPVFLAGERVGSAGILLSWNTPPNPNGRIISYVVKYKEVCPWMQTAYTRVRakPDSLEVLLTNLNPGTTYEIKVAAEN 136
Cdd:cd00063 1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVTP--GSETSYTLTGLKPGTEYEFRVRAVN 78
|
90
....*....|....*
gi 568967537 137 SAGIGVFSDPFLFQT 151
Cdd:cd00063 79 GGGESPPSESVTVTT 93
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
668-755 |
8.28e-15 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 71.76 E-value: 8.28e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 668 SSPQDVKVTDVSPSELSLTWSPPEKPNGIIIAYEVFYQNADA-----LFVKNTSTTNITLSDLKPYTLYNISIQSYTRLG 742
Cdd:cd00063 2 SPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSgdwkeVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81
|
90
....*....|...
gi 568967537 743 HGNQSSSlLSVRT 755
Cdd:cd00063 82 ESPPSES-VTVTT 93
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
570-654 |
3.64e-14 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 69.83 E-value: 3.64e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 570 PSSIQIINYKNISSSSILLYWDPPEYPNGKITHYTIYAMELDTNRAFQMTTV---DNSFLITGLKKYTRYKMRVAASTHV 646
Cdd:cd00063 1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVTpgsETSYTLTGLKPGTEYEFRVRAVNGG 80
|
....*...
gi 568967537 647 GESSLSEE 654
Cdd:cd00063 81 GESPPSES 88
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
57-141 |
1.13e-13 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 68.02 E-value: 1.13e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 57 PGPPVFLAGERVGSAGILLSWNTPPNPNGRiiSYVVKYKEVCPWMQTAYTRVRAKPDSLEVLLTNLNPGTTYEIKVAAEN 136
Cdd:smart00060 1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGIT--GYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVN 78
|
....*
gi 568967537 137 SAGIG 141
Cdd:smart00060 79 GAGEG 83
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
58-144 |
1.40e-12 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 65.13 E-value: 1.40e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 58 GPPVFLAGERVGSAGILLSWNTPPNPNGRIISYVVKYKEVcpWMQTAYTRVRAKPDSLEVLLTNLNPGTTYEIKVAAENS 137
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPK--NSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNG 78
|
....*..
gi 568967537 138 AGIGVFS 144
Cdd:pfam00041 79 GGEGPPS 85
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
668-744 |
2.01e-12 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 64.56 E-value: 2.01e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 668 SSPQDVKVTDVSPSELSLTWSPPEKPNGI--IIAYEVFYQNADALFVK---NTSTTNITLSDLKPYTLYNISIQSYTRLG 742
Cdd:smart00060 2 SPPSNLRVTDVTSTSVTLSWEPPPDDGITgyIVGYRVEYREEGSEWKEvnvTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81
|
..
gi 568967537 743 HG 744
Cdd:smart00060 82 EG 83
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
762-850 |
2.29e-12 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 64.83 E-value: 2.29e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 762 SAPENITYKNISSEEIEIFFLPPRSPNGIIQKYTIYLKRSNSHEARTIET---TSLTLTIGGLKKYTHYVIEVSASTLKG 838
Cdd:cd00063 2 SPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVtpgSETSYTLTGLKPGTEYEFRVRAVNGGG 81
|
90
....*....|..
gi 568967537 839 EGVRSMPISILT 850
Cdd:cd00063 82 ESPPSESVTVTT 93
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
571-652 |
2.88e-11 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 61.28 E-value: 2.88e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 571 SSIQIINYKNISSSSILLYWDPPEYPNGKITHYTIYAMELDTNRAFQMTTVDN---SFLITGLKKYTRYKMRVAASTHVG 647
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSGEPWNEITVPGtttSVTLTGLKPGTEYEVRVQAVNGGG 80
|
....*
gi 568967537 648 ESSLS 652
Cdd:pfam00041 81 EGPPS 85
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
857-934 |
1.19e-10 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 59.74 E-value: 1.19e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 857 SPPQNFSVKQLSGVTVMLSWQPPLEPNGIILYYTVYVWDKVSLK-----TINATEVSLELSDLDYHADYSAYVTASTRFG 931
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSGEpwneiTVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80
|
...
gi 568967537 932 DGK 934
Cdd:pfam00041 81 EGP 83
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
570-649 |
5.24e-10 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 57.62 E-value: 5.24e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 570 PSSIQIINYKNISSSSILLYWDPPEYPN--GKITHYTIYAMELDTN-RAFQMTTVDNSFLITGLKKYTRYKMRVAASTHV 646
Cdd:smart00060 1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGitGYIVGYRVEYREEGSEwKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80
|
...
gi 568967537 647 GES 649
Cdd:smart00060 81 GEG 83
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
1342-1421 |
8.65e-10 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 57.51 E-value: 8.65e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 1342 PDAVQNIACVARDWQSVSVMWDPPRKANGIIIHYMITV----EGNSTKVSPRDP---MYTFTKLLANTSYIFEVRASTSA 1414
Cdd:cd00063 1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYrekgSGDWKEVEVTPGsetSYTLTGLKPGTEYEFRVRAVNGG 80
|
....*..
gi 568967537 1415 GEGNESQ 1421
Cdd:cd00063 81 GESPPSE 87
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
857-944 |
1.29e-09 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 56.74 E-value: 1.29e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 857 SPPQNFSVKQLSGVTVMLSWQPPLEPNGIILYYTVYVWDK-----VSLKTINATEVSLELSDLDYHADYSAYVTASTRFG 931
Cdd:cd00063 2 SPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKgsgdwKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81
|
90
....*....|...
gi 568967537 932 DGKtRSSVINFRT 944
Cdd:cd00063 82 ESP-PSESVTVTT 93
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
1343-1420 |
5.29e-09 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 54.73 E-value: 5.29e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 1343 DAVQNIACVARDWQSVSVMWDPPRKANGIIIHYMITV-------EGNSTKVSPRDPMYTFTKLLANTSYIFEVRASTSAG 1415
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYrpknsgePWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80
|
....*
gi 568967537 1416 EGNES 1420
Cdd:pfam00041 81 EGPPS 85
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
951-1049 |
5.68e-09 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 55.20 E-value: 5.68e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 951 DPPKDVHYVNLSSSSIILFWTPPVKPNGIIQYYSVYYQNTSSTFVQnftllEVTQEPGNVTvSARIYKLAVFSYYTFWLT 1030
Cdd:cd00063 2 SPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWK-----EVEVTPGSET-SYTLTGLKPGTEYEFRVR 75
|
90
....*....|....*....
gi 568967537 1031 ASTLVGNGnKSSDVIHVYT 1049
Cdd:cd00063 76 AVNGGGES-PPSESVTVTT 93
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
1342-1417 |
2.02e-08 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 53.00 E-value: 2.02e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 1342 PDAVQNIACVARDWQSVSVMWDPPRKANGI--IIHYMITVEGNSTK-----VSPRDPMYTFTKLLANTSYIFEVRASTSA 1414
Cdd:smart00060 1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGITgyIVGYRVEYREEGSEwkevnVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80
|
...
gi 568967537 1415 GEG 1417
Cdd:smart00060 81 GEG 83
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
308-393 |
4.81e-08 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 52.50 E-value: 4.81e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 308 GPPQNCITGNVTGKAFSISWDPPAIVTGKF-SYRVELY----GPTGRILDNSTKDLRFVFTHLTPFTMYDVYVAAETSAG 382
Cdd:cd00063 2 SPPTNLRVTDVTSTSVTLSWTPPEDDGGPItGYVVEYRekgsGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81
|
90
....*....|.
gi 568967537 383 VGPKSNLSVFT 393
Cdd:cd00063 82 ESPPSESVTVT 92
|
|
| UP_III |
cd09968 |
Uroplakin III; Uroplakin IIIa and IIIb, the dimerization partners of uroplakin Ib, are a ... |
1766-1928 |
5.00e-08 |
|
Uroplakin III; Uroplakin IIIa and IIIb, the dimerization partners of uroplakin Ib, are a members of the uroplakin family. Uroplakins (UPs) are a family of proteins that associate with each other to form plaques on the apical surface of the urothelium, the pseudo-stratified epithelium lining the urinary tract from renal pelvis to the bladder outlet. UPs are classified into 3 types: UPIa and UPIb, UPII, and UPIIIa and IIIb. UPIs are tetraspanins that have four transmembrane domains seperating one large and one small extracellular domain while UPII and UPIIIs are single-pass transmembrane proteins. UPIa and UPIb form specific heterodimers with UPII and UPIII, respectively, which allows them to exit the endoplasmatic rediculum. UPII/UPIa and UPIIIs/UPIb form heterotetramers and six of these tetramers form the 16nm particle, seen in the hexagonal array of the asymmetric unit membrane, which is believed to form a urinary tract barrier. Uroplakins are also believed to play a role during urinary tract morphogenesis.
Pssm-ID: 197377 Cd Length: 187 Bit Score: 55.08 E-value: 5.00e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 1766 VTSTTITIRMPICYYNDDHGPIRNVQVLVAEAGAQQ----DGNVTKWYDAY--FNKARPYFTNEG-FPNPPCiegkTKFS 1838
Cdd:cd09968 18 PTSTTFTLEQPRCVFDSSASDTDDVWLVVAVSNATNnfnaPQNSTDPISTYsqFSGGQYYLTLRAsRDLYPC----GNPS 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 1839 GNEEIYVIGADNACmipgNEEKICNGPLKPKKQYLFKFRATNVMGQFTDSEYSDPIkTLGEGLSERTVE----------I 1908
Cdd:cd09968 94 LNAYVLRVGADGNC----TDNGNCNGPLPGPGPYRVKYLVMNGSGVVAQTNWSDPI-RLNQAKSYQTIDtwpgrrsggmI 168
|
170 180
....*....|....*....|
gi 568967537 1909 ILSVTLCILSIILLGtAIFA 1928
Cdd:cd09968 169 VITSILSVLLALLLL-ALLA 187
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
762-843 |
2.74e-07 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 50.11 E-value: 2.74e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 762 SAPENITYKNISSEEIEIFFLPPRSPNGIIQKYTIYLKRSNSHEA---RTIETTSLTLTIGGLKKYTHYVIEVSASTLKG 838
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSGEPwneITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80
|
....*
gi 568967537 839 EGVRS 843
Cdd:pfam00041 81 EGPPS 85
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
951-1041 |
3.20e-07 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 49.72 E-value: 3.20e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 951 DPPKDVHYVNLSSSSIILFWTPPVKPNGIIQYYSVYYQNTSStfvqnfTLLEVTQEPGNVTVSARIYKLAVFSYYTFWLT 1030
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNS------GEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQ 74
|
90
....*....|.
gi 568967537 1031 ASTLVGNGNKS 1041
Cdd:pfam00041 75 AVNGGGEGPPS 85
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
308-387 |
1.47e-06 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 47.79 E-value: 1.47e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 308 GPPQNCITGNVTGKAFSISWDPPAIVTGKF-SYRVELYGPTG------RILDNSTKdlRFVFTHLTPFTMYDVYVAAETS 380
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGPItGYEVEYRPKNSgepwneITVPGTTT--SVTLTGLKPGTEYEVRVQAVNG 78
|
....*..
gi 568967537 381 AGVGPKS 387
Cdd:pfam00041 79 GGEGPPS 85
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
308-384 |
1.69e-06 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 47.61 E-value: 1.69e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 308 GPPQNCITGNVTGKAFSISWDPPAiVTGKFSYRVELY------GPTGRILDNSTKDLRFVFTHLTPFTMYDVYVAAETSA 381
Cdd:smart00060 2 SPPSNLRVTDVTSTSVTLSWEPPP-DDGITGYIVGYRveyreeGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80
|
...
gi 568967537 382 GVG 384
Cdd:smart00060 81 GEG 83
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
762-840 |
2.27e-06 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 47.22 E-value: 2.27e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 762 SAPENITYKNISSEEIEIFFLPPRSPNGI--IQKYTIYLKRSNSHEARTIETTSLT-LTIGGLKKYTHYVIEVSASTLKG 838
Cdd:smart00060 2 SPPSNLRVTDVTSTSVTLSWEPPPDDGITgyIVGYRVEYREEGSEWKEVNVTPSSTsYTLTGLKPGTEYEFRVRAVNGAG 81
|
..
gi 568967537 839 EG 840
Cdd:smart00060 82 EG 83
|
|
| FN3 |
COG3401 |
Fibronectin type 3 domain [General function prediction only]; |
26-166 |
2.78e-06 |
|
Fibronectin type 3 domain [General function prediction only];
Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 52.31 E-value: 2.78e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 26 DDTVYDITLSSISAT----TYSSPVSRTlaTNVSKPGPPVFLAGERVGSAGILLSWNtpPNPNGRIISYVVKYKEvcpWM 101
Cdd:COG3401 294 NGTTYYYRVTAVDAAgnesAPSNVVSVT--TDLTPPAAPSGLTATAVGSSSITLSWT--ASSDADVTGYNVYRST---SG 366
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568967537 102 QTAYTRVRAKPDSLEVLLTNLNPGTTYEIKVAAENSAGI-GVFSDPFLFQTAESAPGKVVNLTVEA 166
Cdd:COG3401 367 GGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTAVDAAGNeSAPSEEVSATTASAASGESLTASVDA 432
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
1645-1734 |
4.67e-06 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 46.72 E-value: 4.67e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 1645 DPPNNMTFQKIPDevTKFQLSFLPPSQPNGNIQVYQaLVYREDDPTAVQIHNLSIIqkTDTSVIamLEGLKGGHTYNISV 1724
Cdd:cd00063 2 SPPTNLRVTDVTS--TSVTLSWTPPEDDGGPITGYV-VEYREKGSGDWKEVEVTPG--SETSYT--LTGLKPGTEYEFRV 74
|
90
....*....|
gi 568967537 1725 YAINSAGAGP 1734
Cdd:cd00063 75 RAVNGGGESP 84
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
1645-1734 |
6.01e-06 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 46.25 E-value: 6.01e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 1645 DPPNNMTFQKIPDevTKFQLSFLPPSQPNGNIQVYQaLVYREDDPTAVQIHnlsiIQKTDTSVIAMLEGLKGGHTYNISV 1724
Cdd:pfam00041 1 SAPSNLTVTDVTS--TSLTVSWTPPPDGNGPITGYE-VEYRPKNSGEPWNE----ITVPGTTTSVTLTGLKPGTEYEVRV 73
|
90
....*....|
gi 568967537 1725 YAINSAGAGP 1734
Cdd:pfam00041 74 QAVNGGGEGP 83
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
857-933 |
1.59e-05 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 44.91 E-value: 1.59e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 857 SPPQNFSVKQLSGVTVMLSWQPPLEPNGI--ILYYTVYVWDKVSLK---TINATEVSLELSDLDYHADYSAYVTASTRFG 931
Cdd:smart00060 2 SPPSNLRVTDVTSTSVTLSWEPPPDDGITgyIVGYRVEYREEGSEWkevNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81
|
..
gi 568967537 932 DG 933
Cdd:smart00060 82 EG 83
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
951-1038 |
2.28e-05 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 44.53 E-value: 2.28e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 951 DPPKDVHYVNLSSSSIILFWTPPVKPNGIiqYYSVYYQNTSSTFVQNFTLLEVTQEPGNVTVSariyKLAVFSYYTFWLT 1030
Cdd:smart00060 2 SPPSNLRVTDVTSTSVTLSWEPPPDDGIT--GYIVGYRVEYREEGSEWKEVNVTPSSTSYTLT----GLKPGTEYEFRVR 75
|
....*...
gi 568967537 1031 ASTLVGNG 1038
Cdd:smart00060 76 AVNGAGEG 83
|
|
| FN3 |
COG3401 |
Fibronectin type 3 domain [General function prediction only]; |
76-441 |
2.94e-05 |
|
Fibronectin type 3 domain [General function prediction only];
Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 49.23 E-value: 2.94e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 76 SWNTPPNPNGRIISYVVKYKEVCPWMQTAYTRVRAKPDSLEVLLTNLNPGTTYEIKVAAENSAGIGVFSDPFLFQTAESA 155
Cdd:COG3401 1 TGSSYLTSLDAGIAASAAANTAVNALSKAGGSGKTILVYLAVVLSVTTKESPGTLLVAAGLSSGGGLGTGGRAGTTSGVA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 156 PGKVVNLTVEALNYSAVNLIWYLPRQPNGKITSFKISVKHARSGIVVKDVSIKVEDLLSGKLPECNENSDSFLWSTTSPS 235
Cdd:COG3401 81 AVAVAAAPPTATGLTTLTGSGSVGGATNTGLTSSDEVPSPAVGTATTATAVAGGAATAGTYALGAGLYGVDGANASGTTA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 236 PTLSRATPPLRTTHLSNTLARNKISSVWKEPISFVVTHLRPYTTYLFEVSAVTTEAGYIDSTIVR-TPESVPEGPPQNCI 314
Cdd:COG3401 161 SSVAGAGVVVSPDTSATAAVATTSLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSvTTPTTPPSAPTGLT 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 315 TGNVTGKAFSISWDPPAI--VTGKFSYRVELYGPTGRILdNSTKDLRFVFTHLTPFTMYDVYVAAETSAGV-GPKSN-LS 390
Cdd:COG3401 241 ATADTPGSVTLSWDPVTEsdATGYRVYRSNSGDGPFTKV-ATVTTTSYTDTGLTNGTTYYYRVTAVDAAGNeSAPSNvVS 319
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 568967537 391 VFTPPDVPGAVFDLQIVEVEATEIRVSWRKPrqPNGIISQYRVKVSVLESG 441
Cdd:COG3401 320 VTTDLTPPAAPSGLTATAVGSSSITLSWTAS--SDADVTGYNVYRSTSGGG 368
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
1645-1733 |
7.67e-04 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 40.29 E-value: 7.67e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 1645 DPPNNMTFQKIPDevTKFQLSFLPPSQPNGN--IQVYQaLVYREDDPTAVQIHNlsiiQKTDTSVIamLEGLKGGHTYNI 1722
Cdd:smart00060 2 SPPSNLRVTDVTS--TSVTLSWEPPPDDGITgyIVGYR-VEYREEGSEWKEVNV----TPSSTSYT--LTGLKPGTEYEF 72
|
90
....*....|.
gi 568967537 1723 SVYAINSAGAG 1733
Cdd:smart00060 73 RVRAVNGAGEG 83
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
399-441 |
8.00e-04 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 40.09 E-value: 8.00e-04
10 20 30 40
....*....|....*....|....*....|....*....|...
gi 568967537 399 GAVFDLQIVEVEATEIRVSWRKPRQPNGIISQYRVKVSVLESG 441
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSG 43
|
|
| PTP_tm |
pfam18861 |
TM proximal of protein tyrosine phosphatase, receptor type J; Protein tyrosine phosphatases ... |
1781-1894 |
1.39e-03 |
|
TM proximal of protein tyrosine phosphatase, receptor type J; Protein tyrosine phosphatases (PTPs) are known to be signaling molecules that regulate a variety of cellular processes, including cell growth, differentiation, mitotic cycle, and oncogenic transformation. PTP receptor type J possesses an extracellular region containing five fibronectin type III repeats, the transmembrane region included in this Pfam entry, and a intracytoplasmic catalytic domain. This entry probably contains part of a Fn3 domain at the N-terminus.
Pssm-ID: 465889 Cd Length: 126 Bit Score: 40.67 E-value: 1.39e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 1781 NDDHGPIRNVQVLV--AEAGAQQDGN-VTK-WYDAYFNKARPYFTNEgFPNPpcieGKTKFSGNEEIYVIGADNACMipg 1856
Cdd:pfam18861 7 NSSNGPIKAYGVIVttNDSLNRPLKEyLNKtYYDWKYKKTDSYLATV-TPNP----FTSPRSSSRSLTVPVGTGSKW--- 78
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 568967537 1857 neEKICNGPLKPKKQYLF--------KFRATNVMGQ---FTDSEYSDPI 1894
Cdd:pfam18861 79 --QGYCNGPLKPLGSYRFsvaaftrlEFDDGLIDGEesyVSFTPFSEPI 125
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
398-441 |
1.99e-03 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 39.40 E-value: 1.99e-03
10 20 30 40
....*....|....*....|....*....|....*....|....
gi 568967537 398 PGAVFDLQIVEVEATEIRVSWRKPRQPNGIISQYRVKVSVLESG 441
Cdd:cd00063 1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSG 44
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| FN3 |
COG3401 |
Fibronectin type 3 domain [General function prediction only]; |
1009-1626 |
5.77e-16 |
|
Fibronectin type 3 domain [General function prediction only];
Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 83.90 E-value: 5.77e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 1009 NVTVSARIYKLAVFSYYTFWLTASTLVGNGNKSSDVIHVYTDQDIPEGGVGNLTYESLSSTAINVSWTPPSQPNGLVFYY 1088
Cdd:COG3401 4 SYLTSLDAGIAASAAANTAVNALSKAGGSGKTILVYLAVVLSVTTKESPGTLLVAAGLSSGGGLGTGGRAGTTSGVAAVA 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 1089 VSLnlqqSPPRHRRPPLTTYENSIYFDNLEKYTDYIFKITPStekGFSETYTAQLHIKTEEDVPDTPPIINTFKNLSSTS 1168
Cdd:COG3401 84 VAA----APPTATGLTTLTGSGSVGGATNTGLTSSDEVPSPA---VGTATTATAVAGGAATAGTYALGAGLYGVDGANAS 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 1169 ILLSWDPPLKPNGAILSYHLTLQGTHANRTFVTSGNHIVLEELSPFTLYSFLAAARTMKGLGPSSILFFYTDESAPLAPP 1248
Cdd:COG3401 157 GTTASSVAGAGVVVSPDTSATAAVATTSLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAP 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 1249 QNLTLINYTSDFVWLTWSPSPLPGgivkVYSFKIHEHETDTVFYKNISGFQ----TDAklaGLEPVSTYSISVSAFTKVG 1324
Cdd:COG3401 237 TGLTATADTPGSVTLSWDPVTESD----ATGYRVYRSNSGDGPFTKVATVTttsyTDT---GLTNGTTYYYRVTAVDAAG 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 1325 NGNQFSNVVKFTTQESVPDAVQNIACVARDWQSVSVMWDPP--RKANGIIIHYMITVEGNSTKV--SPRDPMYTFTKLLA 1400
Cdd:COG3401 310 NESAPSNVVSVTTDLTPPAAPSGLTATAVGSSSITLSWTASsdADVTGYNVYRSTSGGGTYTKIaeTVTTTSYTDTGLTP 389
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 1401 NTSYIFEVRASTSAGEGNESQCNVSTLPETVP-------SVPTNTAFSNVQSTSVTLRWIKPDTILGYFQNYKITTqlra 1473
Cdd:COG3401 390 GTTYYYKVTAVDAAGNESAPSEEVSATTASAAsgesltaSVDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTG---- 465
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 1474 qkcrewepeecvehqevqYLYEANQTEDTVRGLKKFQWYRFQVAASTNAGYGNASSWISTQTLPGPPDGPPENVRVVATS 1553
Cdd:COG3401 466 ------------------NAVPFTTTSSTVTATTTDTTTANLSVTTGSLVGGSGASSVTNSVSVIGASAAAAVGGAPDGT 527
|
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568967537 1554 PFGINISWNEPAIITGPTFYLIDVKSVDNDNFNISFVKSNEENKTTEINDLEVFTRYSVVITAFVGNVSGAYT 1626
Cdd:COG3401 528 PNVTGASPVTVGASTGDVLITDLVSLTTSASSSVSGAGLGSGNLYLITTLGGSLLTTTSTNTNDVAGVHGGTL 600
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
668-747 |
1.02e-15 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 73.99 E-value: 1.02e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 668 SSPQDVKVTDVSPSELSLTWSPPEKPNGIIIAYEVFYQNADALFVKNT-----STTNITLSDLKPYTLYNISIQSYTRLG 742
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSGEPWNEitvpgTTTSVTLTGLKPGTEYEVRVQAVNGGG 80
|
....*
gi 568967537 743 HGNQS 747
Cdd:pfam00041 81 EGPPS 85
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
57-151 |
3.16e-15 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 72.91 E-value: 3.16e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 57 PGPPVFLAGERVGSAGILLSWNTPPNPNGRIISYVVKYKEVCPWMQTAYTRVRakPDSLEVLLTNLNPGTTYEIKVAAEN 136
Cdd:cd00063 1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVTP--GSETSYTLTGLKPGTEYEFRVRAVN 78
|
90
....*....|....*
gi 568967537 137 SAGIGVFSDPFLFQT 151
Cdd:cd00063 79 GGGESPPSESVTVTT 93
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
668-755 |
8.28e-15 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 71.76 E-value: 8.28e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 668 SSPQDVKVTDVSPSELSLTWSPPEKPNGIIIAYEVFYQNADA-----LFVKNTSTTNITLSDLKPYTLYNISIQSYTRLG 742
Cdd:cd00063 2 SPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSgdwkeVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81
|
90
....*....|...
gi 568967537 743 HGNQSSSlLSVRT 755
Cdd:cd00063 82 ESPPSES-VTVTT 93
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
570-654 |
3.64e-14 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 69.83 E-value: 3.64e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 570 PSSIQIINYKNISSSSILLYWDPPEYPNGKITHYTIYAMELDTNRAFQMTTV---DNSFLITGLKKYTRYKMRVAASTHV 646
Cdd:cd00063 1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVTpgsETSYTLTGLKPGTEYEFRVRAVNGG 80
|
....*...
gi 568967537 647 GESSLSEE 654
Cdd:cd00063 81 GESPPSES 88
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
57-141 |
1.13e-13 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 68.02 E-value: 1.13e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 57 PGPPVFLAGERVGSAGILLSWNTPPNPNGRiiSYVVKYKEVCPWMQTAYTRVRAKPDSLEVLLTNLNPGTTYEIKVAAEN 136
Cdd:smart00060 1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGIT--GYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVN 78
|
....*
gi 568967537 137 SAGIG 141
Cdd:smart00060 79 GAGEG 83
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
58-144 |
1.40e-12 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 65.13 E-value: 1.40e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 58 GPPVFLAGERVGSAGILLSWNTPPNPNGRIISYVVKYKEVcpWMQTAYTRVRAKPDSLEVLLTNLNPGTTYEIKVAAENS 137
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPK--NSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNG 78
|
....*..
gi 568967537 138 AGIGVFS 144
Cdd:pfam00041 79 GGEGPPS 85
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
668-744 |
2.01e-12 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 64.56 E-value: 2.01e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 668 SSPQDVKVTDVSPSELSLTWSPPEKPNGI--IIAYEVFYQNADALFVK---NTSTTNITLSDLKPYTLYNISIQSYTRLG 742
Cdd:smart00060 2 SPPSNLRVTDVTSTSVTLSWEPPPDDGITgyIVGYRVEYREEGSEWKEvnvTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81
|
..
gi 568967537 743 HG 744
Cdd:smart00060 82 EG 83
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
762-850 |
2.29e-12 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 64.83 E-value: 2.29e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 762 SAPENITYKNISSEEIEIFFLPPRSPNGIIQKYTIYLKRSNSHEARTIET---TSLTLTIGGLKKYTHYVIEVSASTLKG 838
Cdd:cd00063 2 SPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVtpgSETSYTLTGLKPGTEYEFRVRAVNGGG 81
|
90
....*....|..
gi 568967537 839 EGVRSMPISILT 850
Cdd:cd00063 82 ESPPSESVTVTT 93
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
571-652 |
2.88e-11 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 61.28 E-value: 2.88e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 571 SSIQIINYKNISSSSILLYWDPPEYPNGKITHYTIYAMELDTNRAFQMTTVDN---SFLITGLKKYTRYKMRVAASTHVG 647
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSGEPWNEITVPGtttSVTLTGLKPGTEYEVRVQAVNGGG 80
|
....*
gi 568967537 648 ESSLS 652
Cdd:pfam00041 81 EGPPS 85
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
857-934 |
1.19e-10 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 59.74 E-value: 1.19e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 857 SPPQNFSVKQLSGVTVMLSWQPPLEPNGIILYYTVYVWDKVSLK-----TINATEVSLELSDLDYHADYSAYVTASTRFG 931
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSGEpwneiTVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80
|
...
gi 568967537 932 DGK 934
Cdd:pfam00041 81 EGP 83
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
570-649 |
5.24e-10 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 57.62 E-value: 5.24e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 570 PSSIQIINYKNISSSSILLYWDPPEYPN--GKITHYTIYAMELDTN-RAFQMTTVDNSFLITGLKKYTRYKMRVAASTHV 646
Cdd:smart00060 1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGitGYIVGYRVEYREEGSEwKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80
|
...
gi 568967537 647 GES 649
Cdd:smart00060 81 GEG 83
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
1342-1421 |
8.65e-10 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 57.51 E-value: 8.65e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 1342 PDAVQNIACVARDWQSVSVMWDPPRKANGIIIHYMITV----EGNSTKVSPRDP---MYTFTKLLANTSYIFEVRASTSA 1414
Cdd:cd00063 1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYrekgSGDWKEVEVTPGsetSYTLTGLKPGTEYEFRVRAVNGG 80
|
....*..
gi 568967537 1415 GEGNESQ 1421
Cdd:cd00063 81 GESPPSE 87
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
1432-1535 |
9.35e-10 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 57.12 E-value: 9.35e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 1432 PSVPTNTAFSNVQSTSVTLRWIKPDTILGYFQNYKIttqlraqkcrEWEPEECVEHQEVQYLYeANQTEDTVRGLKKFQW 1511
Cdd:cd00063 1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVV----------EYREKGSGDWKEVEVTP-GSETSYTLTGLKPGTE 69
|
90 100
....*....|....*....|....
gi 568967537 1512 YRFQVAASTNAGYGNASSWISTQT 1535
Cdd:cd00063 70 YEFRVRAVNGGGESPPSESVTVTT 93
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
1152-1233 |
1.16e-09 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 57.12 E-value: 1.16e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 1152 PDTPPIInTFKNLSSTSILLSWDPPLKPNGAILSYHLTLQGTHANR-----TFVTSGNHIVLEELSPFTLYSFLAAARTM 1226
Cdd:cd00063 1 PSPPTNL-RVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDwkeveVTPGSETSYTLTGLKPGTEYEFRVRAVNG 79
|
....*..
gi 568967537 1227 KGLGPSS 1233
Cdd:cd00063 80 GGESPPS 86
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
857-944 |
1.29e-09 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 56.74 E-value: 1.29e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 857 SPPQNFSVKQLSGVTVMLSWQPPLEPNGIILYYTVYVWDK-----VSLKTINATEVSLELSDLDYHADYSAYVTASTRFG 931
Cdd:cd00063 2 SPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKgsgdwKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81
|
90
....*....|...
gi 568967537 932 DGKtRSSVINFRT 944
Cdd:cd00063 82 ESP-PSESVTVTT 93
|
|
| FN3 |
COG3401 |
Fibronectin type 3 domain [General function prediction only]; |
536-913 |
4.85e-09 |
|
Fibronectin type 3 domain [General function prediction only];
Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 61.56 E-value: 4.85e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 536 RLVPFTEHTISVSAFTVMGEGPP-TVLTVRTREQVPSSIQIINYKNISSSSILLYWDPPEYPNgkITHYTIYAMELDTNR 614
Cdd:COG3401 198 DIEPGTTYYYRVAATDTGGESAPsNEVSVTTPTTPPSAPTGLTATADTPGSVTLSWDPVTESD--ATGYRVYRSNSGDGP 275
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 615 AFQMTTV-DNSFLITGLKKYTRYKMRVAASTHVG-ESSLSEENDLfvrTPEDEPESSPQDVKVTDVSPSELSLTWSPPek 692
Cdd:COG3401 276 FTKVATVtTTSYTDTGLTNGTTYYYRVTAVDAAGnESAPSNVVSV---TTDLTPPAAPSGLTATAVGSSSITLSWTAS-- 350
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 693 PNGIIIAYEVFYQNADALFV----KNTSTTNITLSDLKPYTLYNISIQSYTRLGHGNQSSSLLSVRTSETVPDSAPEN-- 766
Cdd:COG3401 351 SDADVTGYNVYRSTSGGGTYtkiaETVTTTSYTDTGLTPGTTYYYKVTAVDAAGNESAPSEEVSATTASAASGESLTAsv 430
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 767 ITYKNISSEEIEIFFLPPRSPNGIIQKY--TIYLKRSNSHEARTIETTSLTLTIGGLKKYTHYVIEVSASTLKGEGVRSM 844
Cdd:COG3401 431 DAVPLTDVAGATAAASAASNPGVSAAVLadGGDTGNAVPFTTTSSTVTATTTDTTTANLSVTTGSLVGGSGASSVTNSVS 510
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568967537 845 PISILTEEDAPDSPPQNFSVKQLSGVTVMLSWQPPLEPNGIILYYTVYVWDKVSLKTINATEVSLELSD 913
Cdd:COG3401 511 VIGASAAAAVGGAPDGTPNVTGASPVTVGASTGDVLITDLVSLTTSASSSVSGAGLGSGNLYLITTLGG 579
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
1343-1420 |
5.29e-09 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 54.73 E-value: 5.29e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 1343 DAVQNIACVARDWQSVSVMWDPPRKANGIIIHYMITV-------EGNSTKVSPRDPMYTFTKLLANTSYIFEVRASTSAG 1415
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYrpknsgePWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80
|
....*
gi 568967537 1416 EGNES 1420
Cdd:pfam00041 81 EGPPS 85
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
951-1049 |
5.68e-09 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 55.20 E-value: 5.68e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 951 DPPKDVHYVNLSSSSIILFWTPPVKPNGIIQYYSVYYQNTSSTFVQnftllEVTQEPGNVTvSARIYKLAVFSYYTFWLT 1030
Cdd:cd00063 2 SPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWK-----EVEVTPGSET-SYTLTGLKPGTEYEFRVR 75
|
90
....*....|....*....
gi 568967537 1031 ASTLVGNGnKSSDVIHVYT 1049
Cdd:cd00063 76 AVNGGGES-PPSESVTVTT 93
|
|
| FN3 |
COG3401 |
Fibronectin type 3 domain [General function prediction only]; |
707-1077 |
7.57e-09 |
|
Fibronectin type 3 domain [General function prediction only];
Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 60.79 E-value: 7.57e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 707 ADALFVKNTSTTNITLSDLKPYTLYNISIQSYTrLGHGNQSSSLLSVRTSETVPdSAPENITYKNISSEEIEIFFLPprS 786
Cdd:COG3401 181 ATTSLTVTSTTLVDGGGDIEPGTTYYYRVAATD-TGGESAPSNEVSVTTPTTPP-SAPTGLTATADTPGSVTLSWDP--V 256
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 787 PNGIIQKYTIYLKRSNSHEARTI-ETTSLTLTIGGLKKYTHYVIEVSASTLKG-EGVRSMPISILTEEDAPdSPPQNFSV 864
Cdd:COG3401 257 TESDATGYRVYRSNSGDGPFTKVaTVTTTSYTDTGLTNGTTYYYRVTAVDAAGnESAPSNVVSVTTDLTPP-AAPSGLTA 335
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 865 KQLSGVTVMLSWQPPLEPNgiILYYTVYVWDKVSLKTI----NATEVSLELSDLDYHADYSAYVTASTRFGDGKTRSSVI 940
Cdd:COG3401 336 TAVGSSSITLSWTASSDAD--VTGYNVYRSTSGGGTYTkiaeTVTTTSYTDTGLTPGTTYYYKVTAVDAAGNESAPSEEV 413
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 941 NFRT---PEGEPSDPPKDVHYVNLSSSSIILFWTPPVKPNGIIQYYSVYYQNTSSTFVQNFTLLEVTQE---------PG 1008
Cdd:COG3401 414 SATTasaASGESLTASVDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTdtttanlsvTT 493
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568967537 1009 NVTVSARIYKLAVFSYYTFWLTASTLVGNGNKSSDVIHVYTDQDIPEGGVGNLTYESLSSTAINVSWTP 1077
Cdd:COG3401 494 GSLVGGSGASSVTNSVSVIGASAAAAVGGAPDGTPNVTGASPVTVGASTGDVLITDLVSLTTSASSSVS 562
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
1160-1233 |
1.32e-08 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 53.57 E-value: 1.32e-08
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568967537 1160 TFKNLSSTSILLSWDPPLKPNGAILSYHLTLQ---GTHANRTFVTSGNHI--VLEELSPFTLYSFLAAARTMKGLGPSS 1233
Cdd:pfam00041 7 TVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRpknSGEPWNEITVPGTTTsvTLTGLKPGTEYEVRVQAVNGGGEGPPS 85
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
1342-1417 |
2.02e-08 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 53.00 E-value: 2.02e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 1342 PDAVQNIACVARDWQSVSVMWDPPRKANGI--IIHYMITVEGNSTK-----VSPRDPMYTFTKLLANTSYIFEVRASTSA 1414
Cdd:smart00060 1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGITgyIVGYRVEYREEGSEwkevnVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80
|
...
gi 568967537 1415 GEG 1417
Cdd:smart00060 81 GEG 83
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
1247-1337 |
2.25e-08 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 53.27 E-value: 2.25e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 1247 PPQNLTLINYTSDFVWLTWSPSPLPGGIVKVYSFKIHE-HETDTVFYKNISGFQTDAKLAGLEPVSTYSISVSAFTKVGN 1325
Cdd:cd00063 3 PPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREkGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGE 82
|
90
....*....|..
gi 568967537 1326 GnQFSNVVKFTT 1337
Cdd:cd00063 83 S-PPSESVTVTT 93
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
1247-1326 |
2.57e-08 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 52.80 E-value: 2.57e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 1247 PPQNLTLINYTSDFVWLTWSPSPLPGGIVKVYS-FKIHEHETDTVFYKNISGFQTDAKLAGLEPVSTYSISVSAFTKVGN 1325
Cdd:pfam00041 2 APSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEvEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGE 81
|
.
gi 568967537 1326 G 1326
Cdd:pfam00041 82 G 82
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
1247-1326 |
3.26e-08 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 52.62 E-value: 3.26e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 1247 PPQNLTLINYTSDFVWLTWSPSPLPGGIVKVYSFKIHEHETDTVFYK-NISGFQTDAKLAGLEPVSTYSISVSAFTKVGN 1325
Cdd:smart00060 3 PPSNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGSEWKEvNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAGE 82
|
.
gi 568967537 1326 G 1326
Cdd:smart00060 83 G 83
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
308-393 |
4.81e-08 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 52.50 E-value: 4.81e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 308 GPPQNCITGNVTGKAFSISWDPPAIVTGKF-SYRVELY----GPTGRILDNSTKDLRFVFTHLTPFTMYDVYVAAETSAG 382
Cdd:cd00063 2 SPPTNLRVTDVTSTSVTLSWTPPEDDGGPItGYVVEYRekgsGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81
|
90
....*....|.
gi 568967537 383 VGPKSNLSVFT 393
Cdd:cd00063 82 ESPPSESVTVT 92
|
|
| UP_III |
cd09968 |
Uroplakin III; Uroplakin IIIa and IIIb, the dimerization partners of uroplakin Ib, are a ... |
1766-1928 |
5.00e-08 |
|
Uroplakin III; Uroplakin IIIa and IIIb, the dimerization partners of uroplakin Ib, are a members of the uroplakin family. Uroplakins (UPs) are a family of proteins that associate with each other to form plaques on the apical surface of the urothelium, the pseudo-stratified epithelium lining the urinary tract from renal pelvis to the bladder outlet. UPs are classified into 3 types: UPIa and UPIb, UPII, and UPIIIa and IIIb. UPIs are tetraspanins that have four transmembrane domains seperating one large and one small extracellular domain while UPII and UPIIIs are single-pass transmembrane proteins. UPIa and UPIb form specific heterodimers with UPII and UPIII, respectively, which allows them to exit the endoplasmatic rediculum. UPII/UPIa and UPIIIs/UPIb form heterotetramers and six of these tetramers form the 16nm particle, seen in the hexagonal array of the asymmetric unit membrane, which is believed to form a urinary tract barrier. Uroplakins are also believed to play a role during urinary tract morphogenesis.
Pssm-ID: 197377 Cd Length: 187 Bit Score: 55.08 E-value: 5.00e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 1766 VTSTTITIRMPICYYNDDHGPIRNVQVLVAEAGAQQ----DGNVTKWYDAY--FNKARPYFTNEG-FPNPPCiegkTKFS 1838
Cdd:cd09968 18 PTSTTFTLEQPRCVFDSSASDTDDVWLVVAVSNATNnfnaPQNSTDPISTYsqFSGGQYYLTLRAsRDLYPC----GNPS 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 1839 GNEEIYVIGADNACmipgNEEKICNGPLKPKKQYLFKFRATNVMGQFTDSEYSDPIkTLGEGLSERTVE----------I 1908
Cdd:cd09968 94 LNAYVLRVGADGNC----TDNGNCNGPLPGPGPYRVKYLVMNGSGVVAQTNWSDPI-RLNQAKSYQTIDtwpgrrsggmI 168
|
170 180
....*....|....*....|
gi 568967537 1909 ILSVTLCILSIILLGtAIFA 1928
Cdd:cd09968 169 VITSILSVLLALLLL-ALLA 187
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
1432-1525 |
1.91e-07 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 50.31 E-value: 1.91e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 1432 PSVPTNTAFSNVQSTSVTLRWIKP--DTILGYFQNYKITTQlraQKCREWEPEECVEhqevqylyeaNQTEDTVRGLKKF 1509
Cdd:smart00060 1 PSPPSNLRVTDVTSTSVTLSWEPPpdDGITGYIVGYRVEYR---EEGSEWKEVNVTP----------SSTSYTLTGLKPG 67
|
90
....*....|....*.
gi 568967537 1510 QWYRFQVAASTNAGYG 1525
Cdd:smart00060 68 TEYEFRVRAVNGAGEG 83
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
762-843 |
2.74e-07 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 50.11 E-value: 2.74e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 762 SAPENITYKNISSEEIEIFFLPPRSPNGIIQKYTIYLKRSNSHEA---RTIETTSLTLTIGGLKKYTHYVIEVSASTLKG 838
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSGEPwneITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80
|
....*
gi 568967537 839 EGVRS 843
Cdd:pfam00041 81 EGPPS 85
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
951-1041 |
3.20e-07 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 49.72 E-value: 3.20e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 951 DPPKDVHYVNLSSSSIILFWTPPVKPNGIIQYYSVYYQNTSStfvqnfTLLEVTQEPGNVTVSARIYKLAVFSYYTFWLT 1030
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNS------GEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQ 74
|
90
....*....|.
gi 568967537 1031 ASTLVGNGNKS 1041
Cdd:pfam00041 75 AVNGGGEGPPS 85
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
1152-1230 |
1.26e-06 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 47.99 E-value: 1.26e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 1152 PDTPPIInTFKNLSSTSILLSWDPPLKPN--GAILSYHLTLQGTHANRTFVT---SGNHIVLEELSPFTLYSFLAAARTM 1226
Cdd:smart00060 1 PSPPSNL-RVTDVTSTSVTLSWEPPPDDGitGYIVGYRVEYREEGSEWKEVNvtpSSTSYTLTGLKPGTEYEFRVRAVNG 79
|
....
gi 568967537 1227 KGLG 1230
Cdd:smart00060 80 AGEG 83
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
308-387 |
1.47e-06 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 47.79 E-value: 1.47e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 308 GPPQNCITGNVTGKAFSISWDPPAIVTGKF-SYRVELYGPTG------RILDNSTKdlRFVFTHLTPFTMYDVYVAAETS 380
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGPItGYEVEYRPKNSgepwneITVPGTTT--SVTLTGLKPGTEYEVRVQAVNG 78
|
....*..
gi 568967537 381 AGVGPKS 387
Cdd:pfam00041 79 GGEGPPS 85
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
308-384 |
1.69e-06 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 47.61 E-value: 1.69e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 308 GPPQNCITGNVTGKAFSISWDPPAiVTGKFSYRVELY------GPTGRILDNSTKDLRFVFTHLTPFTMYDVYVAAETSA 381
Cdd:smart00060 2 SPPSNLRVTDVTSTSVTLSWEPPP-DDGITGYIVGYRveyreeGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80
|
...
gi 568967537 382 GVG 384
Cdd:smart00060 81 GEG 83
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
1433-1528 |
1.75e-06 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 47.79 E-value: 1.75e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 1433 SVPTNTAFSNVQSTSVTLRWIKPDTILGYFQNYKITTQlraqkcREWEPEECVEHQEVqylyeANQTEDTVRGLKKFQWY 1512
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYR------PKNSGEPWNEITVP-----GTTTSVTLTGLKPGTEY 69
|
90
....*....|....*.
gi 568967537 1513 RFQVAASTNAGYGNAS 1528
Cdd:pfam00041 70 EVRVQAVNGGGEGPPS 85
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
1056-1137 |
1.83e-06 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 47.88 E-value: 1.83e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 1056 GGVGNLTYESLSSTAINVSWTPPSQPNGLVFYY-VSLNLQQSPPRHRRPPLTTYENSIYFDNLEKYTDYIFKITPSTEKG 1134
Cdd:cd00063 2 SPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYvVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81
|
...
gi 568967537 1135 FSE 1137
Cdd:cd00063 82 ESP 84
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
762-840 |
2.27e-06 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 47.22 E-value: 2.27e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 762 SAPENITYKNISSEEIEIFFLPPRSPNGI--IQKYTIYLKRSNSHEARTIETTSLT-LTIGGLKKYTHYVIEVSASTLKG 838
Cdd:smart00060 2 SPPSNLRVTDVTSTSVTLSWEPPPDDGITgyIVGYRVEYREEGSEWKEVNVTPSSTsYTLTGLKPGTEYEFRVRAVNGAG 81
|
..
gi 568967537 839 EG 840
Cdd:smart00060 82 EG 83
|
|
| FN3 |
COG3401 |
Fibronectin type 3 domain [General function prediction only]; |
26-166 |
2.78e-06 |
|
Fibronectin type 3 domain [General function prediction only];
Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 52.31 E-value: 2.78e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 26 DDTVYDITLSSISAT----TYSSPVSRTlaTNVSKPGPPVFLAGERVGSAGILLSWNtpPNPNGRIISYVVKYKEvcpWM 101
Cdd:COG3401 294 NGTTYYYRVTAVDAAgnesAPSNVVSVT--TDLTPPAAPSGLTATAVGSSSITLSWT--ASSDADVTGYNVYRST---SG 366
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568967537 102 QTAYTRVRAKPDSLEVLLTNLNPGTTYEIKVAAENSAGI-GVFSDPFLFQTAESAPGKVVNLTVEA 166
Cdd:COG3401 367 GGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTAVDAAGNeSAPSEEVSATTASAASGESLTASVDA 432
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
1056-1136 |
3.67e-06 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 46.84 E-value: 3.67e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 1056 GGVGNLTYESLSSTAINVSWTPPSQPNGLVFY-YVSLNLQQSPPRHRRPPLTTYENSIYFDNLEKYTDYIFKITPSTEKG 1134
Cdd:smart00060 2 SPPSNLRVTDVTSTSVTLSWEPPPDDGITGYIvGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81
|
..
gi 568967537 1135 FS 1136
Cdd:smart00060 82 EG 83
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
1645-1734 |
4.67e-06 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 46.72 E-value: 4.67e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 1645 DPPNNMTFQKIPDevTKFQLSFLPPSQPNGNIQVYQaLVYREDDPTAVQIHNLSIIqkTDTSVIamLEGLKGGHTYNISV 1724
Cdd:cd00063 2 SPPTNLRVTDVTS--TSVTLSWTPPEDDGGPITGYV-VEYREKGSGDWKEVEVTPG--SETSYT--LTGLKPGTEYEFRV 74
|
90
....*....|
gi 568967537 1725 YAINSAGAGP 1734
Cdd:cd00063 75 RAVNGGGESP 84
|
|
| FN3 |
COG3401 |
Fibronectin type 3 domain [General function prediction only]; |
1498-1731 |
5.78e-06 |
|
Fibronectin type 3 domain [General function prediction only];
Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 51.54 E-value: 5.78e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 1498 QTEDTVRGLKKFQWYRFQVAASTNAGYGNASSWISTQTLPGPPDgPPENVRVVATSPFGINISWNePAIITGPTFYLIDV 1577
Cdd:COG3401 191 TLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPS-APTGLTATADTPGSVTLSWD-PVTESDATGYRVYR 268
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 1578 KSVDNDNFN-ISFVKSNEENKTTEINDlevfTRYSVVITAfvgnVSGAYTDGKSSAEVIITTLESVPkDPPNNMTFQKI- 1655
Cdd:COG3401 269 SNSGDGPFTkVATVTTTSYTDTGLTNG----TTYYYRVTA----VDAAGNESAPSNVVSVTTDLTPP-AAPSGLTATAVg 339
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568967537 1656 PDEVTkfqLSFLPPSQPNgniqVYQALVYREDDPTAvqihNLSIIQKTDTSVIAMLEGLKGGHTYNISVYAINSAG 1731
Cdd:COG3401 340 SSSIT---LSWTASSDAD----VTGYNVYRSTSGGG----TYTKIAETVTTTSYTDTGLTPGTTYYYKVTAVDAAG 404
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
1645-1734 |
6.01e-06 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 46.25 E-value: 6.01e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 1645 DPPNNMTFQKIPDevTKFQLSFLPPSQPNGNIQVYQaLVYREDDPTAVQIHnlsiIQKTDTSVIAMLEGLKGGHTYNISV 1724
Cdd:pfam00041 1 SAPSNLTVTDVTS--TSLTVSWTPPPDGNGPITGYE-VEYRPKNSGEPWNE----ITVPGTTTSVTLTGLKPGTEYEVRV 73
|
90
....*....|
gi 568967537 1725 YAINSAGAGP 1734
Cdd:pfam00041 74 QAVNGGGEGP 83
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
1542-1626 |
1.38e-05 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 45.10 E-value: 1.38e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 1542 GPPENVRVVATSPFGINISWNEPAIITGP-TFYLIDVKSVDNDNFNISFVKSNEENkTTEINDLEVFTRYSVVITAFVGN 1620
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGPiTGYEVEYRPKNSGEPWNEITVPGTTT-SVTLTGLKPGTEYEVRVQAVNGG 79
|
....*.
gi 568967537 1621 VSGAYT 1626
Cdd:pfam00041 80 GEGPPS 85
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
857-933 |
1.59e-05 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 44.91 E-value: 1.59e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 857 SPPQNFSVKQLSGVTVMLSWQPPLEPNGI--ILYYTVYVWDKVSLK---TINATEVSLELSDLDYHADYSAYVTASTRFG 931
Cdd:smart00060 2 SPPSNLRVTDVTSTSVTLSWEPPPDDGITgyIVGYRVEYREEGSEWkevNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81
|
..
gi 568967537 932 DG 933
Cdd:smart00060 82 EG 83
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
951-1038 |
2.28e-05 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 44.53 E-value: 2.28e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 951 DPPKDVHYVNLSSSSIILFWTPPVKPNGIiqYYSVYYQNTSSTFVQNFTLLEVTQEPGNVTVSariyKLAVFSYYTFWLT 1030
Cdd:smart00060 2 SPPSNLRVTDVTSTSVTLSWEPPPDDGIT--GYIVGYRVEYREEGSEWKEVNVTPSSTSYTLT----GLKPGTEYEFRVR 75
|
....*...
gi 568967537 1031 ASTLVGNG 1038
Cdd:smart00060 76 AVNGAGEG 83
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
1542-1638 |
2.71e-05 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 44.79 E-value: 2.71e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 1542 GPPENVRVVATSPFGINISWNEPAIITGP-TFYLIDVKSVDNDNFNISFVKSNEENKTTeINDLEVFTRYSVVITAFvgn 1620
Cdd:cd00063 2 SPPTNLRVTDVTSTSVTLSWTPPEDDGGPiTGYVVEYREKGSGDWKEVEVTPGSETSYT-LTGLKPGTEYEFRVRAV--- 77
|
90
....*....|....*...
gi 568967537 1621 vsGAYTDGKSSAEVIITT 1638
Cdd:cd00063 78 --NGGGESPPSESVTVTT 93
|
|
| FN3 |
COG3401 |
Fibronectin type 3 domain [General function prediction only]; |
76-441 |
2.94e-05 |
|
Fibronectin type 3 domain [General function prediction only];
Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 49.23 E-value: 2.94e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 76 SWNTPPNPNGRIISYVVKYKEVCPWMQTAYTRVRAKPDSLEVLLTNLNPGTTYEIKVAAENSAGIGVFSDPFLFQTAESA 155
Cdd:COG3401 1 TGSSYLTSLDAGIAASAAANTAVNALSKAGGSGKTILVYLAVVLSVTTKESPGTLLVAAGLSSGGGLGTGGRAGTTSGVA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 156 PGKVVNLTVEALNYSAVNLIWYLPRQPNGKITSFKISVKHARSGIVVKDVSIKVEDLLSGKLPECNENSDSFLWSTTSPS 235
Cdd:COG3401 81 AVAVAAAPPTATGLTTLTGSGSVGGATNTGLTSSDEVPSPAVGTATTATAVAGGAATAGTYALGAGLYGVDGANASGTTA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 236 PTLSRATPPLRTTHLSNTLARNKISSVWKEPISFVVTHLRPYTTYLFEVSAVTTEAGYIDSTIVR-TPESVPEGPPQNCI 314
Cdd:COG3401 161 SSVAGAGVVVSPDTSATAAVATTSLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSvTTPTTPPSAPTGLT 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 315 TGNVTGKAFSISWDPPAI--VTGKFSYRVELYGPTGRILdNSTKDLRFVFTHLTPFTMYDVYVAAETSAGV-GPKSN-LS 390
Cdd:COG3401 241 ATADTPGSVTLSWDPVTEsdATGYRVYRSNSGDGPFTKV-ATVTTTSYTDTGLTNGTTYYYRVTAVDAAGNeSAPSNvVS 319
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 568967537 391 VFTPPDVPGAVFDLQIVEVEATEIRVSWRKPrqPNGIISQYRVKVSVLESG 441
Cdd:COG3401 320 VTTDLTPPAAPSGLTATAVGSSSITLSWTAS--SDADVTGYNVYRSTSGGG 368
|
|
| FN3 |
COG3401 |
Fibronectin type 3 domain [General function prediction only]; |
531-774 |
4.00e-05 |
|
Fibronectin type 3 domain [General function prediction only];
Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 48.46 E-value: 4.00e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 531 SYVIRRLVPFTEHTISVSAFTVMGE--GPPTVLTVRTREQVPSSIQIINYKNISSSSILLYWDPPeyPNGKITHYTIYAm 608
Cdd:COG3401 286 SYTDTGLTNGTTYYYRVTAVDAAGNesAPSNVVSVTTDLTPPAAPSGLTATAVGSSSITLSWTAS--SDADVTGYNVYR- 362
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 609 elDTNRAFQMTTV-----DNSFLITGLKKYTRYKMRVAASTHVG-ESSLSEE---NDLFVRTPEDEPESSPQDVKVTDVS 679
Cdd:COG3401 363 --STSGGGTYTKIaetvtTTSYTDTGLTPGTTYYYKVTAVDAAGnESAPSEEvsaTTASAASGESLTASVDAVPLTDVAG 440
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 680 PSELSLTWSPPEKPNGIIIAYEV--FYQNADALFVKNTSTTNITLSDLKPYTLYNISIQSYTRLGHGNQSSSLLSVRTSE 757
Cdd:COG3401 441 ATAAASAASNPGVSAAVLADGGDtgNAVPFTTTSSTVTATTTDTTTANLSVTTGSLVGGSGASSVTNSVSVIGASAAAAV 520
|
250
....*....|....*..
gi 568967537 758 TVPDSAPENITYKNISS 774
Cdd:COG3401 521 GGAPDGTPNVTGASPVT 537
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
1058-1137 |
5.69e-05 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 43.56 E-value: 5.69e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 1058 VGNLTYESLSSTAINVSWTPPSQPNG-LVFYYVSLNLQQSPPRHRRPPLTTYENSIYFDNLEKYTDYIFKITPSTEKGFS 1136
Cdd:pfam00041 3 PSNLTVTDVTSTSLTVSWTPPPDGNGpITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEG 82
|
.
gi 568967537 1137 E 1137
Cdd:pfam00041 83 P 83
|
|
| UP_IIIa |
cd09970 |
Uroplakin IIIa; Uroplakin IIIa, mayor isoform of the dimerization partner of uroplakin Ib, is ... |
1767-1896 |
2.49e-04 |
|
Uroplakin IIIa; Uroplakin IIIa, mayor isoform of the dimerization partner of uroplakin Ib, is a members of the uroplakin family. Uroplakins (UPs) are a family of proteins that associate with each other to form plaques on the apical surface of the urothelium, the pseudo-stratified epithelium lining the urinary tract from renal pelvis to the bladder outlet. UPs are classified into 3 types: UPIa and UPIb, UPII, and UPIIIa and IIIb. UPIs are tetraspanins that have four transmembrane domains seperating one large and one small extracellular domain while UPII and UPIIIs are single-pass transmembrane proteins. UPIa and UPIb form specific heterodimers with UPII and UPIII, respectively, which allows them to exit the endoplasmatic rediculum. UPII/UPIa and UPIIIs/UPIb form heterotetramers and six of these tetramers form the 16nm particle, seen in the hexagonal array of the asymmetric unit membrane, which is believed to form a urinary tract barrier. Uroplakins are also believed to play a role during urinary tract morphogenesis.
Pssm-ID: 197379 Cd Length: 212 Bit Score: 44.59 E-value: 2.49e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 1767 TSTTITIRMPICYYNDDHGPIRNVQV-LVAEAGAQQDGNVTKWYDAYFNKARPYFTNEG----------FPNPPC----- 1830
Cdd:cd09970 20 TLTTITLEKPFCMFDSKEALTGTHEVyLYVLVDSAISRNASVQDSTNTPLGSTFLQTEGgrtgpykaaaFDLPPCsdlps 99
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568967537 1831 ---IEGKTKFSGNEEIYVI--GADNACMIPGNEEKICNGPLKPKKQYLFKFRATNVMGQFTDSE--YSDPIKT 1896
Cdd:cd09970 100 ldaIGDVSKASQILNAYLVrvGANGTCLWDPNFKGLCNPPLSAATEYRFKYVLVNMSTGLVEDQtlWSDPIRT 172
|
|
| FN3 |
COG3401 |
Fibronectin type 3 domain [General function prediction only]; |
13-417 |
2.54e-04 |
|
Fibronectin type 3 domain [General function prediction only];
Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 46.15 E-value: 2.54e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 13 GTSESQVDVSGSFDDTVYDITLSSISATTYSSPVSRTLATNVSKPGPPVFLAGERVGSAGIllSWNTPPNPNGRIISYVV 92
Cdd:COG3401 91 ATGLTTLTGSGSVGGATNTGLTSSDEVPSPAVGTATTATAVAGGAATAGTYALGAGLYGVD--GANASGTTASSVAGAGV 168
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 93 KYKEVCPWMQTAYTRVRAKPDSLEVLLT-NLNPGTTYEIKVAAENSAGIGVFSDPFLFQTAESAPGKVVNLTVEALNYSA 171
Cdd:COG3401 169 VVSPDTSATAAVATTSLTVTSTTLVDGGgDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPTGLTATADTPGS 248
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 172 VNLIWylPRQPNGKITSFKISVKharsgivvkdvsikvedllsgklpecnensdsflwstTSPSPTLSRATpplrtthls 251
Cdd:COG3401 249 VTLSW--DPVTESDATGYRVYRS-------------------------------------NSGDGPFTKVA--------- 280
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 252 nTLARNkissvwkepiSFVVTHLRPYTTYLFEVSAVTTeAGYI--DSTIVR-TPESVPEGPPQNCITGNVTGKAFSISWD 328
Cdd:COG3401 281 -TVTTT----------SYTDTGLTNGTTYYYRVTAVDA-AGNEsaPSNVVSvTTDLTPPAAPSGLTATAVGSSSITLSWT 348
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 329 PPAI--VTGKFSYRVELYGPTGRILDNSTKDLRFVFTHLTPFTMYDVYVAAETSAGV--GPKSNLSVFTPPDVPGAVFDL 404
Cdd:COG3401 349 ASSDadVTGYNVYRSTSGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTAVDAAGNesAPSEEVSATTASAASGESLTA 428
|
410
....*....|...
gi 568967537 405 QIVEVEATEIRVS 417
Cdd:COG3401 429 SVDAVPLTDVAGA 441
|
|
| Pur_ac_phosph_N |
pfam16656 |
Purple acid Phosphatase, N-terminal domain; This domain is found at the N-terminus of Purple ... |
75-151 |
3.97e-04 |
|
Purple acid Phosphatase, N-terminal domain; This domain is found at the N-terminus of Purple acid phosphatase proteins.
Pssm-ID: 465220 [Multi-domain] Cd Length: 93 Bit Score: 41.24 E-value: 3.97e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 75 LSWNTPPNPNGRIISYVVKYKEVCPWM---QTAYTRVRAKPDSL-EVLLTNLNPGTTYEIKVAAENSagigVFSDPFLFQ 150
Cdd:pfam16656 17 VSWVTPSAVTSPVVQYGTSSSALTSTAtatSSTYTTGDGGTGYIhRATLTGLEPGTTYYYRVGDDNG----GWSEVYSFT 92
|
.
gi 568967537 151 T 151
Cdd:pfam16656 93 T 93
|
|
| UP_IIIb |
cd09969 |
Uroplakin IIIb; Uroplakin IIIb, minor isoform of the dimerization partner of uroplakin Ib, is ... |
1766-1928 |
6.66e-04 |
|
Uroplakin IIIb; Uroplakin IIIb, minor isoform of the dimerization partner of uroplakin Ib, is a members of the uroplakin family. Uroplakins (UPs) are a family of proteins that associate with each other to form plaques on the apical surface of the urothelium, the pseudo-stratified epithelium lining the urinary tract from renal pelvis to the bladder outlet. UPs are classified into 3 types: UPIa and UPIb, UPII, and UPIIIa and IIIb. UPIs are tetraspanins that have four transmembrane domains seperating one large and one small extracellular domain while UPII and UPIIIs are single-pass transmembrane proteins. UPIa and UPIb form specific heterodimers with UPII and UPIII, respectively, which allows them to exit the endoplasmatic rediculum. UPII/UPIa and UPIIIs/UPIb form heterotetramers and six of these tetramers form the 16nm particle, seen in the hexagonal array of the asymmetric unit membrane, which is believed to form a urinary tract barrier. Uroplakins are also believed to play a role during urinary tract morphogenesis.
Pssm-ID: 197378 Cd Length: 184 Bit Score: 42.76 E-value: 6.66e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 1766 VTSTTITIRMPICYYNDDHgPIRNVQVLVAEAGAQQD----GNVTKWYDAY-FNKARPYFTNEGFP-NPPCIEGktkfSG 1839
Cdd:cd09969 18 ITSSTFVLEQPRCVFSSSS-DGDDIWLVVALSNATQNfnapVKSSDIPTASsFSTKGYYLTLRASRaLYPCGNP----SM 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 1840 NEEIYVIGADNACmipgnEEKICNGPLKPKKQYLFKFRATNVMGQFTDSEYSDPIkTLGEGLSERTVE----------II 1909
Cdd:cd09969 93 GLPVLRVGADTGC-----TDNNCNGPLPGPGPYRVKFLVMNNRGPVAETNWSDPI-TLRTGKSPQTIDtwpgrrsggmIV 166
|
170
....*....|....*....
gi 568967537 1910 LSVTLCILSIILLGtAIFA 1928
Cdd:cd09969 167 ITTILSVLLALLLL-ALLA 184
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
1645-1733 |
7.67e-04 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 40.29 E-value: 7.67e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 1645 DPPNNMTFQKIPDevTKFQLSFLPPSQPNGN--IQVYQaLVYREDDPTAVQIHNlsiiQKTDTSVIamLEGLKGGHTYNI 1722
Cdd:smart00060 2 SPPSNLRVTDVTS--TSVTLSWEPPPDDGITgyIVGYR-VEYREEGSEWKEVNV----TPSSTSYT--LTGLKPGTEYEF 72
|
90
....*....|.
gi 568967537 1723 SVYAINSAGAG 1733
Cdd:smart00060 73 RVRAVNGAGEG 83
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
399-441 |
8.00e-04 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 40.09 E-value: 8.00e-04
10 20 30 40
....*....|....*....|....*....|....*....|...
gi 568967537 399 GAVFDLQIVEVEATEIRVSWRKPRQPNGIISQYRVKVSVLESG 441
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSG 43
|
|
| PTP_tm |
pfam18861 |
TM proximal of protein tyrosine phosphatase, receptor type J; Protein tyrosine phosphatases ... |
1781-1894 |
1.39e-03 |
|
TM proximal of protein tyrosine phosphatase, receptor type J; Protein tyrosine phosphatases (PTPs) are known to be signaling molecules that regulate a variety of cellular processes, including cell growth, differentiation, mitotic cycle, and oncogenic transformation. PTP receptor type J possesses an extracellular region containing five fibronectin type III repeats, the transmembrane region included in this Pfam entry, and a intracytoplasmic catalytic domain. This entry probably contains part of a Fn3 domain at the N-terminus.
Pssm-ID: 465889 Cd Length: 126 Bit Score: 40.67 E-value: 1.39e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 1781 NDDHGPIRNVQVLV--AEAGAQQDGN-VTK-WYDAYFNKARPYFTNEgFPNPpcieGKTKFSGNEEIYVIGADNACMipg 1856
Cdd:pfam18861 7 NSSNGPIKAYGVIVttNDSLNRPLKEyLNKtYYDWKYKKTDSYLATV-TPNP----FTSPRSSSRSLTVPVGTGSKW--- 78
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 568967537 1857 neEKICNGPLKPKKQYLF--------KFRATNVMGQ---FTDSEYSDPI 1894
Cdd:pfam18861 79 --QGYCNGPLKPLGSYRFsvaaftrlEFDDGLIDGEesyVSFTPFSEPI 125
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
398-441 |
1.99e-03 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 39.40 E-value: 1.99e-03
10 20 30 40
....*....|....*....|....*....|....*....|....
gi 568967537 398 PGAVFDLQIVEVEATEIRVSWRKPRQPNGIISQYRVKVSVLESG 441
Cdd:cd00063 1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSG 44
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
1542-1623 |
3.14e-03 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 38.36 E-value: 3.14e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 1542 GPPENVRVVATSPFGINISWNEPAiITGPTFYLIDVKSVDND-NFNISFVKSNEENKTTEINDLEVFTRYSVVITAFVGN 1620
Cdd:smart00060 2 SPPSNLRVTDVTSTSVTLSWEPPP-DDGITGYIVGYRVEYREeGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80
|
...
gi 568967537 1621 VSG 1623
Cdd:smart00060 81 GEG 83
|
|
| UP_III_II |
cd09966 |
Uroplakin IIIb, IIIa and II; Uroplakins (UPs) are a family of proteins that associate with ... |
1760-1927 |
6.24e-03 |
|
Uroplakin IIIb, IIIa and II; Uroplakins (UPs) are a family of proteins that associate with each other to form plaques on the apical surface of the urothelium, the pseudo-stratified epithelium lining the urinary tract from renal pelvis to the bladder outlet. UPs are classified into 3 types: UPIa and UPIb, UPII, and UPIIIa and IIIb. UPIs are tetraspanins that have four transmembrane domains separating one large and one small extracellular domain while UPII and UPIIIs are single-pass transmembrane proteins. UPIa and UPIb form specific heterodimers with UPII and UPIII, respectively, which allows them to exit the endoplasmatic rediculum. UPII/UPIa and UPIIIs/UPIb form heterotetramers; six of these tetramers form the 16nm particle, seen in the hexagonal array of the asymmetric unit membrane, which is believed to form a urinary tract barrier. Uroplakins are also believed to play a role during urinary tract morphogenesis.
Pssm-ID: 197375 Cd Length: 181 Bit Score: 39.71 E-value: 6.24e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 1760 ATGKLLVTSTTITIRMPICYYndDHGPIRNVQVLVAEAGAQQDG-NVTKWYDAYF------NKARPYFTNEgFPNPPCie 1832
Cdd:cd09966 10 STGAGNPTLSTFTLEQPPCMF--DSSSTDDVWLVVALPNATLAFqNVTLSTDISTyltfttGNYYKTLRAS-FDLPPC-- 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967537 1833 GKTKFSGNEEIYVIGADNACMipgneEKICNGPLKPKKQYLFKFRATNVMGQFTDSEYSDPIKTLGEGLSERTVE----- 1907
Cdd:cd09966 85 RNRRDIVSAYVLRVGNTTTCL-----SGYCNTPLPGPGPYRVKYLVMNGSGPSAQTEWSTPIRLNQNKIYSTTWPgarsg 159
|
170 180
....*....|....*....|..
gi 568967537 1908 --IILSVTLCILSIILLGTAIF 1927
Cdd:cd09966 160 gmIVITVILSVLMFLLLVALIA 181
|
|
| |
