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Conserved domains on  [gi|568967574|ref|XP_006513716|]
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thrombospondin-type laminin G domain and EAR repeat-containing protein isoform X1 [Mus musculus]

Protein Classification

LamG domain-containing protein; M14 family metallopeptidase( domain architecture ID 10430276)

LamG (Laminin G) domain-containing protein may serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules; similar to Oncorhynchus mykiss sex hormone-binding globulin beta form that may participate in the local control of ovarian functions in salmonids| M14 family metallopeptidase is a zinc-binding carboxypeptidase which hydrolyzes a single, C-terminal amino acid from a polypeptide chain, and has a recognition site for the free C-terminal carboxyl group

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 361-407 2.88e-15

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


:

Pssm-ID: 461033  Cd Length: 41  Bit Score: 69.42  E-value: 2.88e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 568967574  361 KFVSYQNIATHQAQSWRHFTIGKKIFLAVANFgpnergQEFSVIYKW 407
Cdd:pfam03736   1 KFVPYQTIPTRGARDVEPFSIGGDLFLAVANF------SGDSVIYRW 41
LamG super family cl22861
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 46-223 3.52e-14

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


The actual alignment was detected with superfamily member smart00210:

Pssm-ID: 473984  Cd Length: 184  Bit Score: 70.85  E-value: 3.52e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967574    46 TSGIRmvQVEGVRGLQ--FSATEPRTTSFPASRIFSSCdfFPEEFSIIVTLRvpnLPPKKNEYLLSLLAEErDTLLLGLR 123
Cdd:smart00210  14 SFAIR--QVVGPEPGSpaYRLGDPALVPQPTRDLFPSG--LPEDFSLLTTFR---QTPKSRGVLFAIYDAQ-NVRQFGLE 85

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967574   124 YSPTQLHFLFLSEDLAGAWQTrVSFWSPGLMDSRWHTLILAVSQGSFSLTTDCGLPVDIMADVSFPPTLSVRGARFFIGs 203
Cdd:smart00210  86 VDGRANTLLLRYQGVDGKQHT-VSFRNLPLADGQWHKLALSVSGSSATLYVDCNEIDSRPLDRPGQPPIDTDGIEVRGA- 163

                          170       180
                   ....*....|....*....|
gi 568967574   204 RKRTKGLFTGVIRQLVLLPG 223
Cdd:smart00210 164 QAADRKPFQGDLQQLKIVCD 183
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 413-447 6.09e-11

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


:

Pssm-ID: 461033  Cd Length: 41  Bit Score: 57.09  E-value: 6.09e-11
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 568967574  413 KFTLYQRIATHSARDWEAFEVDGEHFLVVANHREG 447
Cdd:pfam03736   1 KFVPYQTIPTRGARDVEPFSIGGDLFLAVANFSGD 35
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 317-357 8.35e-03

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


:

Pssm-ID: 461033  Cd Length: 41  Bit Score: 34.37  E-value: 8.35e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 568967574  317 EEHQSLHTNSeTLGIEVFSIPGVgLFAAAANRKARSAIYKW 357
Cdd:pfam03736   3 VPYQTIPTRG-ARDVEPFSIGGD-LFLAVANFSGDSVIYRW 41
 
Name Accession Description Interval E-value
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 361-407 2.88e-15

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


Pssm-ID: 461033  Cd Length: 41  Bit Score: 69.42  E-value: 2.88e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 568967574  361 KFVSYQNIATHQAQSWRHFTIGKKIFLAVANFgpnergQEFSVIYKW 407
Cdd:pfam03736   1 KFVPYQTIPTRGARDVEPFSIGGDLFLAVANF------SGDSVIYRW 41
TSPN smart00210
Thrombospondin N-terminal -like domains; Heparin-binding and cell adhesion domain of ...
 46-223 3.52e-14

Thrombospondin N-terminal -like domains; Heparin-binding and cell adhesion domain of thrombospondin


Pssm-ID: 214560  Cd Length: 184  Bit Score: 70.85  E-value: 3.52e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967574    46 TSGIRmvQVEGVRGLQ--FSATEPRTTSFPASRIFSSCdfFPEEFSIIVTLRvpnLPPKKNEYLLSLLAEErDTLLLGLR 123
Cdd:smart00210  14 SFAIR--QVVGPEPGSpaYRLGDPALVPQPTRDLFPSG--LPEDFSLLTTFR---QTPKSRGVLFAIYDAQ-NVRQFGLE 85

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967574   124 YSPTQLHFLFLSEDLAGAWQTrVSFWSPGLMDSRWHTLILAVSQGSFSLTTDCGLPVDIMADVSFPPTLSVRGARFFIGs 203
Cdd:smart00210  86 VDGRANTLLLRYQGVDGKQHT-VSFRNLPLADGQWHKLALSVSGSSATLYVDCNEIDSRPLDRPGQPPIDTDGIEVRGA- 163

                          170       180
                   ....*....|....*....|
gi 568967574   204 RKRTKGLFTGVIRQLVLLPG 223
Cdd:smart00210 164 QAADRKPFQGDLQQLKIVCD 183
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 413-447 6.09e-11

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


Pssm-ID: 461033  Cd Length: 41  Bit Score: 57.09  E-value: 6.09e-11
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 568967574  413 KFTLYQRIATHSARDWEAFEVDGEHFLVVANHREG 447
Cdd:pfam03736   1 KFVPYQTIPTRGARDVEPFSIGGDLFLAVANFSGD 35
Laminin_G_1 pfam00054
Laminin G domain;
112-220 7.21e-03

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 36.91  E-value: 7.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967574  112 AEERDTLLLGLRYSPTQLHFlflseDLAGAWQTRVSfwSPGLMDSRWHTLILAVSQGSFSLTTDCGLPVDIMADVSFPPT 191
Cdd:pfam00054  16 QTERDFLALELRDGRLEVSY-----DLGSGAAVVRS--GDKLNDGKWHSVELERNGRSGTLSVDGEARPTGESPLGATTD 88

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 568967574  192 LSVRGARFFIGSRKRTKGL--------FTGVIRQLVL 220
Cdd:pfam00054  89 LDVDGPLYVGGLPSLGVKKrrlaispsFDGCIRDVIV 125
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 317-357 8.35e-03

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


Pssm-ID: 461033  Cd Length: 41  Bit Score: 34.37  E-value: 8.35e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 568967574  317 EEHQSLHTNSeTLGIEVFSIPGVgLFAAAANRKARSAIYKW 357
Cdd:pfam03736   3 VPYQTIPTRG-ARDVEPFSIGGD-LFLAVANFSGDSVIYRW 41
 
Name Accession Description Interval E-value
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 361-407 2.88e-15

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


Pssm-ID: 461033  Cd Length: 41  Bit Score: 69.42  E-value: 2.88e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 568967574  361 KFVSYQNIATHQAQSWRHFTIGKKIFLAVANFgpnergQEFSVIYKW 407
Cdd:pfam03736   1 KFVPYQTIPTRGARDVEPFSIGGDLFLAVANF------SGDSVIYRW 41
TSPN smart00210
Thrombospondin N-terminal -like domains; Heparin-binding and cell adhesion domain of ...
 46-223 3.52e-14

Thrombospondin N-terminal -like domains; Heparin-binding and cell adhesion domain of thrombospondin


Pssm-ID: 214560  Cd Length: 184  Bit Score: 70.85  E-value: 3.52e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967574    46 TSGIRmvQVEGVRGLQ--FSATEPRTTSFPASRIFSSCdfFPEEFSIIVTLRvpnLPPKKNEYLLSLLAEErDTLLLGLR 123
Cdd:smart00210  14 SFAIR--QVVGPEPGSpaYRLGDPALVPQPTRDLFPSG--LPEDFSLLTTFR---QTPKSRGVLFAIYDAQ-NVRQFGLE 85

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967574   124 YSPTQLHFLFLSEDLAGAWQTrVSFWSPGLMDSRWHTLILAVSQGSFSLTTDCGLPVDIMADVSFPPTLSVRGARFFIGs 203
Cdd:smart00210  86 VDGRANTLLLRYQGVDGKQHT-VSFRNLPLADGQWHKLALSVSGSSATLYVDCNEIDSRPLDRPGQPPIDTDGIEVRGA- 163

                          170       180
                   ....*....|....*....|
gi 568967574   204 RKRTKGLFTGVIRQLVLLPG 223
Cdd:smart00210 164 QAADRKPFQGDLQQLKIVCD 183
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 413-447 6.09e-11

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


Pssm-ID: 461033  Cd Length: 41  Bit Score: 57.09  E-value: 6.09e-11
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 568967574  413 KFTLYQRIATHSARDWEAFEVDGEHFLVVANHREG 447
Cdd:pfam03736   1 KFVPYQTIPTRGARDVEPFSIGGDLFLAVANFSGD 35
LamG smart00282
Laminin G domain;
116-220 1.78e-03

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 38.47  E-value: 1.78e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967574   116 DTLLLGLRYSptQLHFLFlseDLaGAWQTRVSFWSPGLMDSRWHTLILAVSQGSFSLTTDCGLPVDIMADvSFPPTLSVR 195
Cdd:smart00282  25 DYLALELRDG--RLVLRY---DL-GSGPARLTSDPTPLNDGQWHRVAVERNGRSVTLSVDGGNRVSGESP-GGLTILNLD 97

                           90       100       110
                   ....*....|....*....|....*....|...
gi 568967574   196 GaRFFIGSRKRTKGL--------FTGVIRQLVL 220
Cdd:smart00282  98 G-PLYLGGLPEDLKLpplpvtpgFRGCIRNLKV 129
Laminin_G_1 pfam00054
Laminin G domain;
112-220 7.21e-03

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 36.91  E-value: 7.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967574  112 AEERDTLLLGLRYSPTQLHFlflseDLAGAWQTRVSfwSPGLMDSRWHTLILAVSQGSFSLTTDCGLPVDIMADVSFPPT 191
Cdd:pfam00054  16 QTERDFLALELRDGRLEVSY-----DLGSGAAVVRS--GDKLNDGKWHSVELERNGRSGTLSVDGEARPTGESPLGATTD 88

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 568967574  192 LSVRGARFFIGSRKRTKGL--------FTGVIRQLVL 220
Cdd:pfam00054  89 LDVDGPLYVGGLPSLGVKKrrlaispsFDGCIRDVIV 125
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 317-357 8.35e-03

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


Pssm-ID: 461033  Cd Length: 41  Bit Score: 34.37  E-value: 8.35e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 568967574  317 EEHQSLHTNSeTLGIEVFSIPGVgLFAAAANRKARSAIYKW 357
Cdd:pfam03736   3 VPYQTIPTRG-ARDVEPFSIGGD-LFLAVANFSGDSVIYRW 41
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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