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Conserved domains on  [gi|568968430|ref|XP_006514125|]
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group XIIB secretory phospholipase A2-like protein isoform X2 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Phospholip_A2_3 super family cl29745
Prokaryotic phospholipase A2; The prokaryotic phospholipase A2 domain is predominantly found ...
 59-206 2.21e-74

Prokaryotic phospholipase A2; The prokaryotic phospholipase A2 domain is predominantly found in bacterial and fungal phospholipases, as well as various hypothetical and putative proteins. It enables the liberation of fatty acids and lysophospholipid by hydrolysing the 2-ester bond of 1,2-diacyl-3-sn-phosphoglycerides. The domain adopts an alpha-helical secondary structure, consisting of five alpha-helices and two helical segments.


The actual alignment was detected with superfamily member pfam06951:

Pssm-ID: 453050  Cd Length: 186  Bit Score: 223.53  E-value: 2.21e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968430   59 LLWLGLVGNLAQSDPSPKEEESYSDW--GLRQLRGSFESVNSYVDSFMELLGGKNGVCQYRCRYGKAPMPRPGYKAQEPN 136
Cdd:pfam06951   3 LLGHGAAGSDTLRDAIAAAEDVFSDWrkGLNHIRGGFESVDGYFDAALELLGGRDGVCQYKCRYGKTPVPRPGYKPPEPN 82

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968430  137 GCSSYFLGIKvpgsMDLGIPAMTKCCNQLDVCYDTCGANKYRCDAKFRWCLHSICSDLKRSLGFVSNVEA 206
Cdd:pfam06951  83 GCGSYFLGLK----MDLGIPAMTKCCNQHDICYDTCGSNKYRCDEKFRWCLHSICSDLKKSLGFVSNVEA 148
 
Name Accession Description Interval E-value
PLA2G12 pfam06951
Group XII secretory phospholipase A2 precursor (PLA2G12); This family consists of several ...
 59-206 2.21e-74

Group XII secretory phospholipase A2 precursor (PLA2G12); This family consists of several group XII secretory phospholipase A2 precursor (PLA2G12) (EC:3.1.1.4) proteins. Group XII and group V PLA(2)s are thought to participate in helper T cell immune response through release of immediate second signals and generation of downstream eicosanoids.


Pssm-ID: 399731  Cd Length: 186  Bit Score: 223.53  E-value: 2.21e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968430   59 LLWLGLVGNLAQSDPSPKEEESYSDW--GLRQLRGSFESVNSYVDSFMELLGGKNGVCQYRCRYGKAPMPRPGYKAQEPN 136
Cdd:pfam06951   3 LLGHGAAGSDTLRDAIAAAEDVFSDWrkGLNHIRGGFESVDGYFDAALELLGGRDGVCQYKCRYGKTPVPRPGYKPPEPN 82

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968430  137 GCSSYFLGIKvpgsMDLGIPAMTKCCNQLDVCYDTCGANKYRCDAKFRWCLHSICSDLKRSLGFVSNVEA 206
Cdd:pfam06951  83 GCGSYFLGLK----MDLGIPAMTKCCNQHDICYDTCGSNKYRCDEKFRWCLHSICSDLKKSLGFVSNVEA 148
 
Name Accession Description Interval E-value
PLA2G12 pfam06951
Group XII secretory phospholipase A2 precursor (PLA2G12); This family consists of several ...
 59-206 2.21e-74

Group XII secretory phospholipase A2 precursor (PLA2G12); This family consists of several group XII secretory phospholipase A2 precursor (PLA2G12) (EC:3.1.1.4) proteins. Group XII and group V PLA(2)s are thought to participate in helper T cell immune response through release of immediate second signals and generation of downstream eicosanoids.


Pssm-ID: 399731  Cd Length: 186  Bit Score: 223.53  E-value: 2.21e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968430   59 LLWLGLVGNLAQSDPSPKEEESYSDW--GLRQLRGSFESVNSYVDSFMELLGGKNGVCQYRCRYGKAPMPRPGYKAQEPN 136
Cdd:pfam06951   3 LLGHGAAGSDTLRDAIAAAEDVFSDWrkGLNHIRGGFESVDGYFDAALELLGGRDGVCQYKCRYGKTPVPRPGYKPPEPN 82

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968430  137 GCSSYFLGIKvpgsMDLGIPAMTKCCNQLDVCYDTCGANKYRCDAKFRWCLHSICSDLKRSLGFVSNVEA 206
Cdd:pfam06951  83 GCGSYFLGLK----MDLGIPAMTKCCNQHDICYDTCGSNKYRCDEKFRWCLHSICSDLKKSLGFVSNVEA 148
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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