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Conserved domains on  [gi|568979303|ref|XP_006515763|]
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ubiquinone biosynthesis monooxygenase COQ6, mitochondrial isoform X2 [Mus musculus]

Protein Classification

Rossmann-fold NAD(P)-binding domain-containing protein( domain architecture ID 229380)

Rossmann-fold NAD(P)-binding domain-containing protein may function as an oxidoreductase

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NADB_Rossmann super family cl21454
Rossmann-fold NAD(P)(+)-binding proteins; A large family of proteins that share a ...
 45-388 0e+00

Rossmann-fold NAD(P)(+)-binding proteins; A large family of proteins that share a Rossmann-fold NAD(P)H/NAD(P)(+) binding (NADB) domain. The NADB domain is found in numerous dehydrogenases of metabolic pathways such as glycolysis, and many other redox enzymes. NAD binding involves numerous hydrogen-bonds and van der Waals contacts, in particular H-bonding of residues in a turn between the first strand and the subsequent helix of the Rossmann-fold topology. Characteristically, this turn exhibits a consensus binding pattern similar to GXGXXG, in which the first 2 glycines participate in NAD(P)-binding, and the third facilitates close packing of the helix to the beta-strand. Typically, proteins in this family contain a second domain in addition to the NADB domain, which is responsible for specifically binding a substrate and catalyzing a particular enzymatic reaction.


The actual alignment was detected with superfamily member TIGR01989:

Pssm-ID: 473865 [Multi-domain]  Cd Length: 437  Bit Score: 535.88  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979303   45 VWDSCSEALIMFDRDN-LDDMGYIVENDVIMYALTKQLEAV-ADRVKVLYESKAVGYSWPGAfSMADSSPWVHITLGDGS 122
Cdd:TIGR01989  90 VWDGCSLALIRFDRDNgKEDMACIIENDNIQNSLYNRLQEYnGDNVKILNPARLISVTIPSK-YPNDNSNWVHITLSDGQ 168

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979303  123 TLQTKLLIGADGHKSGVRQAAGIQNVSWKYDQSAVVATLHLSEATENNVAWQRFLPSGPIALLPLSDTLSSLVWSTSHEH 202
Cdd:TIGR01989 169 VLYTKLLIGADGSNSNVRKAANIDTTGWNYNQHAVVATLKLEEATENDVAWQRFLPTGPIALLPLPDNNSTLVWSTSPEE 248

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979303  203 AAELVSMDEEEFVDAINSAF---WSDVHHTDFVDSASAMVRHAVALLKPTKVSARQLPPSIAKVDAKSRALFPLGLGHAA 279
Cdd:TIGR01989 249 ALRLLSLPPEDFVDALNAAFdlgYSDHPYSYLLDYAMEKLNEDIGFRTEGSKSCFQVPPRVIGVVDKSRAAFPLGLGHAD 328

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979303  280 EYVRPRVALIGDAAHRIHPLAGQGVNMGFGDISSLVHHLSTAAFNGKDLGSMSHLTGYETDRQRHNTALLAATDLLKRLY 359
Cdd:TIGR01989 329 EYVTKRVALVGDAAHRVHPLAGQGVNLGFGDVASLVKALAEAVSVGADIGSISSLKPYERERYAKNVVLLGLVDKLHKLY 408

                         330       340
                  ....*....|....*....|....*....
gi 568979303  360 STSATPLVLLRTWGLQATNAVSPLKEQIM 388
Cdd:TIGR01989 409 ATDFPPVVALRTFGLNLTNYIGPLKNFIM 437
 
Name Accession Description Interval E-value
COQ6 TIGR01989
ubiquinone biosynthesis monooxygenase COQ6; This model represents the monooxygenase ...
 45-388 0e+00

ubiquinone biosynthesis monooxygenase COQ6; This model represents the monooxygenase responsible for the 4-hydroxylateion of the phenol ring in the aerobic biosynthesis of ubiquinone


Pssm-ID: 273914 [Multi-domain]  Cd Length: 437  Bit Score: 535.88  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979303   45 VWDSCSEALIMFDRDN-LDDMGYIVENDVIMYALTKQLEAV-ADRVKVLYESKAVGYSWPGAfSMADSSPWVHITLGDGS 122
Cdd:TIGR01989  90 VWDGCSLALIRFDRDNgKEDMACIIENDNIQNSLYNRLQEYnGDNVKILNPARLISVTIPSK-YPNDNSNWVHITLSDGQ 168

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979303  123 TLQTKLLIGADGHKSGVRQAAGIQNVSWKYDQSAVVATLHLSEATENNVAWQRFLPSGPIALLPLSDTLSSLVWSTSHEH 202
Cdd:TIGR01989 169 VLYTKLLIGADGSNSNVRKAANIDTTGWNYNQHAVVATLKLEEATENDVAWQRFLPTGPIALLPLPDNNSTLVWSTSPEE 248

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979303  203 AAELVSMDEEEFVDAINSAF---WSDVHHTDFVDSASAMVRHAVALLKPTKVSARQLPPSIAKVDAKSRALFPLGLGHAA 279
Cdd:TIGR01989 249 ALRLLSLPPEDFVDALNAAFdlgYSDHPYSYLLDYAMEKLNEDIGFRTEGSKSCFQVPPRVIGVVDKSRAAFPLGLGHAD 328

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979303  280 EYVRPRVALIGDAAHRIHPLAGQGVNMGFGDISSLVHHLSTAAFNGKDLGSMSHLTGYETDRQRHNTALLAATDLLKRLY 359
Cdd:TIGR01989 329 EYVTKRVALVGDAAHRVHPLAGQGVNLGFGDVASLVKALAEAVSVGADIGSISSLKPYERERYAKNVVLLGLVDKLHKLY 408

                         330       340
                  ....*....|....*....|....*....
gi 568979303  360 STSATPLVLLRTWGLQATNAVSPLKEQIM 388
Cdd:TIGR01989 409 ATDFPPVVALRTFGLNLTNYIGPLKNFIM 437
PRK07364 PRK07364
FAD-dependent hydroxylase;
56-384 9.10e-66

FAD-dependent hydroxylase;


Pssm-ID: 236001 [Multi-domain]  Cd Length: 415  Bit Score: 214.88  E-value: 9.10e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979303  56 FDRDNL--DDMGYIVENDVIMYALTKQLEAvADRVKVLYESKAVGYSWPGAFsmadsspwVHITL---GDGSTLQTKLLI 130
Cdd:PRK07364 104 FQPTDLgtEALGYVGEHQVLLEALQEFLQS-CPNITWLCPAEVVSVEYQQDA--------ATVTLeieGKQQTLQSKLVV 174

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979303 131 GADGHKSGVRQAAGIQNVSWKYDQSAVVATLHLsEATENNVAWQRFLPSGPIALLPLSDTLSSLVWSTSHEHAAELVSMD 210
Cdd:PRK07364 175 AADGARSPIRQAAGIKTKGWKYWQSCVTATVKH-EAPHNDIAYERFWPSGPFAILPLPGNRCQIVWTAPHAQAKALLALP 253

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979303 211 EEEFVdainsafwsdvhhtdfvdsasamvrhavALLKptkvsaRQLPPSIAKVDAKS-RALFPLGLGHAAEYVRPRVALI 289
Cdd:PRK07364 254 EAEFL----------------------------AELQ------QRYGDQLGKLELLGdRFLFPVQLMQSDRYVQHRLALV 299

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979303 290 GDAAHRIHPLAGQGVNMGFGDISSLVHHLSTAAFNGKDLGSMSHLTGYETDRQRHNTALLAATDLLKRLYSTSATPLVLL 369
Cdd:PRK07364 300 GDAAHCCHPVGGQGLNLGIRDAAALAQVLQTAHQRGEDIGSLAVLKRYERWRKRENWLILGFTDLLDRLFSNQWWPLVVV 379

                        330
                 ....*....|....*
gi 568979303 370 RTWGLQATNAVSPLK 384
Cdd:PRK07364 380 RRLGLWLLRHVPPLK 394
UbiH COG0654
2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme ...
 65-384 1.99e-34

2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme transport and metabolism, Energy production and conversion]; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 440419 [Multi-domain]  Cd Length: 326  Bit Score: 129.67  E-value: 1.99e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979303  65 GYIVENDVIMYALTKQLEAvaDRVKVLYESKAVGYSWPGAFsmadsspwVHITLGDGSTLQTKLLIGADGHKSGVRQAAG 144
Cdd:COG0654   98 GLVVPRADLERALLEAARA--LGVELRFGTEVTGLEQDADG--------VTVTLADGRTLRADLVVGADGARSAVRRLLG 167

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979303 145 IQNVSWKYDQSAVVATLHLseatennvawqrflpsgpiallplsdtlsslvwstshehaaelvsmdeeEFVDAINSAFWs 224
Cdd:COG0654  168 IGFTGRDYPQRALWAGVRT-------------------------------------------------ELRARLAAAGP- 197

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979303 225 dvhhtdfvdsasamvrHAVALLkptkvsarqlppsiakvDAKSRALFPLGLGHAAEYVRPRVALIGDAAHRIHPLAGQGV 304
Cdd:COG0654  198 ----------------RLGELL-----------------ELSPRSAFPLRRRRAERWRRGRVVLLGDAAHTMHPLGGQGA 244

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979303 305 NMGFGDISSLVHHLStAAFNGKDLGSMshLTGYETDRQRHNTALLAATDLLKRLYSTSATPLVLLRTWGLQATNAVSPLK 384
Cdd:COG0654  245 NLALRDAAALAWKLA-AALRGRDDEAA--LARYERERRPRAARVQRAADALGRLFHPDSPPLRLLRNAGLRLLDRLPPLK 321
FAD_binding_3 pfam01494
FAD binding domain; This domain is involved in FAD binding in a number of enzymes.
 119-352 1.10e-09

FAD binding domain; This domain is involved in FAD binding in a number of enzymes.


Pssm-ID: 396193 [Multi-domain]  Cd Length: 348  Bit Score: 59.26  E-value: 1.10e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979303  119 GDGSTLQTKLLIGADGHKSGVRQAAGIQNVSWKYDQSAVVATLHLS------EATENNVAWQRFLPSGPIALLPLSDTLS 192
Cdd:pfam01494 143 GEEYTVRAKYLVGCDGGRSPVRKTLGIEFEGFEGVPFGSLDVLFDApdlsdpVERAFVHYLIYAPHSRGFMVGPWRSAGR 222

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979303  193 S---LVWSTSHEHAAELVSMDEEEFVDAINSAfwsdvHHTDFVDsasamvrhavallkptkvsarqlppsiAKVDAKSRa 269
Cdd:pfam01494 223 EryyVQVPWDEEVEERPEEFTDEELKQRLRSI-----VGIDLAL---------------------------VEILWKSI- 269

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979303  270 lFPLGLGHAAEYVRPRVALIGDAAHRIHPLAGQGVNMGFGDISSLVHHLStAAFNGKdlGSMSHLTGYETDRQRHNTALL 349
Cdd:pfam01494 270 -WGVASRVATRYRKGRVFLAGDAAHIHPPTGGQGLNTAIQDAFNLAWKLA-AVLRGQ--AGESLLDTYSAERLPVAWAVV 345


                  ...
gi 568979303  350 AAT 352
Cdd:pfam01494 346 DFA 348
 
Name Accession Description Interval E-value
COQ6 TIGR01989
ubiquinone biosynthesis monooxygenase COQ6; This model represents the monooxygenase ...
 45-388 0e+00

ubiquinone biosynthesis monooxygenase COQ6; This model represents the monooxygenase responsible for the 4-hydroxylateion of the phenol ring in the aerobic biosynthesis of ubiquinone


Pssm-ID: 273914 [Multi-domain]  Cd Length: 437  Bit Score: 535.88  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979303   45 VWDSCSEALIMFDRDN-LDDMGYIVENDVIMYALTKQLEAV-ADRVKVLYESKAVGYSWPGAfSMADSSPWVHITLGDGS 122
Cdd:TIGR01989  90 VWDGCSLALIRFDRDNgKEDMACIIENDNIQNSLYNRLQEYnGDNVKILNPARLISVTIPSK-YPNDNSNWVHITLSDGQ 168

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979303  123 TLQTKLLIGADGHKSGVRQAAGIQNVSWKYDQSAVVATLHLSEATENNVAWQRFLPSGPIALLPLSDTLSSLVWSTSHEH 202
Cdd:TIGR01989 169 VLYTKLLIGADGSNSNVRKAANIDTTGWNYNQHAVVATLKLEEATENDVAWQRFLPTGPIALLPLPDNNSTLVWSTSPEE 248

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979303  203 AAELVSMDEEEFVDAINSAF---WSDVHHTDFVDSASAMVRHAVALLKPTKVSARQLPPSIAKVDAKSRALFPLGLGHAA 279
Cdd:TIGR01989 249 ALRLLSLPPEDFVDALNAAFdlgYSDHPYSYLLDYAMEKLNEDIGFRTEGSKSCFQVPPRVIGVVDKSRAAFPLGLGHAD 328

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979303  280 EYVRPRVALIGDAAHRIHPLAGQGVNMGFGDISSLVHHLSTAAFNGKDLGSMSHLTGYETDRQRHNTALLAATDLLKRLY 359
Cdd:TIGR01989 329 EYVTKRVALVGDAAHRVHPLAGQGVNLGFGDVASLVKALAEAVSVGADIGSISSLKPYERERYAKNVVLLGLVDKLHKLY 408

                         330       340
                  ....*....|....*....|....*....
gi 568979303  360 STSATPLVLLRTWGLQATNAVSPLKEQIM 388
Cdd:TIGR01989 409 ATDFPPVVALRTFGLNLTNYIGPLKNFIM 437
Ubi-OHases TIGR01988
Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; This model represents a ...
 45-392 1.44e-129

Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; This model represents a family of FAD-dependent hydroxylases (monooxygenases) which are all believed to act in the aerobic ubiquinone biosynthesis pathway. A separate set of hydroxylases, as yet undiscovered, are believed to be active under anaerobic conditions. In E. coli three enzyme activities have been described, UbiB (which acts first at position 6, see TIGR01982), UbiH (which acts at position 4) and UbiF (which acts at position 5). UbiH and UbiF are similar to one another and form the basis of this subfamily. Interestingly, E. coli contains another hydroxylase gene, called visC, that is highly similar to UbiF, adjacent to UbiH and, when mutated, results in a phenotype similar to that of UbiH (which has also been named visB). Several other species appear to have three homologs in this family, although they assort themselves differently on phylogenetic trees (e.g. Xylella and Mesorhizobium) making it difficult to ascribe a specific activity to each one. Eukaryotes appear to have only a single homolog in this subfamily (COQ6) which complements UbiH, but also possess a non-orthologous gene, COQ7 which complements UbiF. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273913 [Multi-domain]  Cd Length: 385  Bit Score: 377.31  E-value: 1.44e-129
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979303   45 VWDSCSEALIMFDRD--NLDDMGYIVENDVIMYALTKQLEavadrvkvlyESKAVGYSWPGAF-SMADSSPWVHITLGDG 121
Cdd:TIGR01988  78 VSDGGSFGALRFDADeiGLEALGYVVENRVLQQALWERLQ----------ELPNVTLLCPARVvELPRHSDHVELTLDDG 147

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979303  122 STLQTKLLIGADGHKSGVRQAAGIQNVSWKYDQSAVVATLHLSEATeNNVAWQRFLPSGPIALLPLSDTLSSLVWSTSHE 201
Cdd:TIGR01988 148 QQLRARLLVGADGANSKVRQLAGIPTTGWDYGQSAVVANVKHERPH-QGTAWERFTPTGPLALLPLPDNRSSLVWTLPPE 226

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979303  202 HAAELVSMDEEEFVDAINSAFWSdvhhtdfvdsasamvrhavallkptkvsarQLPPSiakVDAKSRALFPLGLGHAAEY 281
Cdd:TIGR01988 227 EAERLLALSDEEFLAELQRAFGS------------------------------RLGAI---TLVGERHAFPLSLTHAKRY 273

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979303  282 VRPRVALIGDAAHRIHPLAGQGVNMGFGDISSLVHHLSTAAFNGKDLGSMSHLTGYETDRQRHNTALLAATDLLKRLYST 361
Cdd:TIGR01988 274 VAPRLALIGDAAHTIHPLAGQGLNLGLRDVAALAEVLEDARRRGEDIGSLRVLQRYERRRRFDNAAMLGATDGLNRLFSN 353

                         330       340       350
                  ....*....|....*....|....*....|.
gi 568979303  362 SATPLVLLRTWGLQATNAVSPLKEQIMAFAS 392
Cdd:TIGR01988 354 DFPPLRLLRNLGLRLLNNLPPLKNFIARYAM 384
PRK07364 PRK07364
FAD-dependent hydroxylase;
56-384 9.10e-66

FAD-dependent hydroxylase;


Pssm-ID: 236001 [Multi-domain]  Cd Length: 415  Bit Score: 214.88  E-value: 9.10e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979303  56 FDRDNL--DDMGYIVENDVIMYALTKQLEAvADRVKVLYESKAVGYSWPGAFsmadsspwVHITL---GDGSTLQTKLLI 130
Cdd:PRK07364 104 FQPTDLgtEALGYVGEHQVLLEALQEFLQS-CPNITWLCPAEVVSVEYQQDA--------ATVTLeieGKQQTLQSKLVV 174

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979303 131 GADGHKSGVRQAAGIQNVSWKYDQSAVVATLHLsEATENNVAWQRFLPSGPIALLPLSDTLSSLVWSTSHEHAAELVSMD 210
Cdd:PRK07364 175 AADGARSPIRQAAGIKTKGWKYWQSCVTATVKH-EAPHNDIAYERFWPSGPFAILPLPGNRCQIVWTAPHAQAKALLALP 253

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979303 211 EEEFVdainsafwsdvhhtdfvdsasamvrhavALLKptkvsaRQLPPSIAKVDAKS-RALFPLGLGHAAEYVRPRVALI 289
Cdd:PRK07364 254 EAEFL----------------------------AELQ------QRYGDQLGKLELLGdRFLFPVQLMQSDRYVQHRLALV 299

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979303 290 GDAAHRIHPLAGQGVNMGFGDISSLVHHLSTAAFNGKDLGSMSHLTGYETDRQRHNTALLAATDLLKRLYSTSATPLVLL 369
Cdd:PRK07364 300 GDAAHCCHPVGGQGLNLGIRDAAALAQVLQTAHQRGEDIGSLAVLKRYERWRKRENWLILGFTDLLDRLFSNQWWPLVVV 379

                        330
                 ....*....|....*
gi 568979303 370 RTWGLQATNAVSPLK 384
Cdd:PRK07364 380 RRLGLWLLRHVPPLK 394
PRK08850 PRK08850
2-octaprenyl-6-methoxyphenol hydroxylase; Validated
 37-391 4.07e-64

2-octaprenyl-6-methoxyphenol hydroxylase; Validated


Pssm-ID: 236341 [Multi-domain]  Cd Length: 405  Bit Score: 210.40  E-value: 4.07e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979303  37 LAPQPCSAVWDSCSEALIMFDRDNL--DDMGYIVENDVIMYALTKQLEAvADRVKVLYESKAvgyswpGAFSMADSSPWv 114
Cdd:PRK08850  75 AAPYIAMEVWEQDSFARIEFDAESMaqPDLGHIVENRVIQLALLEQVQK-QDNVTLLMPARC------QSIAVGESEAW- 146

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979303 115 hITLGDGSTLQTKLLIGADGHKSGVRQAAGIQNVSWKYDQSAVVATLHLSEaTENNVAWQRFLPSGPIALLPLSDT-LSS 193
Cdd:PRK08850 147 -LTLDNGQALTAKLVVGADGANSWLRRQMDIPLTHWDYGHSALVANVRTVD-PHNSVARQIFTPQGPLAFLPMSEPnMSS 224

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979303 194 LVWSTSHEHAAELVSMDEEEFVDAINSAFwsdvhhtdfvDSasamvrhavallkptkvsarQLppSIAKVDAkSRALFPL 273
Cdd:PRK08850 225 IVWSTEPLRAEALLAMSDEQFNKALTAEF----------DN--------------------RL--GLCEVVG-ERQAFPL 271

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979303 274 GLGHAAEYVRPRVALIGDAAHRIHPLAGQGVNMGFGDISSLVHHLSTAAFNGKDLGSMSHLTGYETDRQRHNTALLAATD 353
Cdd:PRK08850 272 KMRYARDFVRERVALVGDAAHTIHPLAGQGVNLGLLDAASLAQEILALWQQGRDIGLKRNLRGYERWRKAEAAKMIAAMQ 351

                        330       340       350
                 ....*....|....*....|....*....|....*...
gi 568979303 354 LLKRLYSTSATPLVLLRTWGLQATNAVSPLKEQIMAFA 391
Cdd:PRK08850 352 GFRDLFSGSNPAKKLVRGIGMSLAGQLPGAKDEIMKRA 389
PRK07333 PRK07333
ubiquinone biosynthesis hydroxylase;
66-385 5.35e-64

ubiquinone biosynthesis hydroxylase;


Pssm-ID: 180935 [Multi-domain]  Cd Length: 403  Bit Score: 209.84  E-value: 5.35e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979303  66 YIVENDVIMYALTKQLEAVAdrVKVLYESKAVGyswpgaFSMADSSpwVHITLGDGSTLQTKLLIGADGHKSGVRQAAGI 145
Cdd:PRK07333 106 HMVENRVLINALRKRAEALG--IDLREATSVTD------FETRDEG--VTVTLSDGSVLEARLLVAADGARSKLRELAGI 175

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979303 146 QNVSWKYDQSAVVATL-HlsEATENNVAWQRFLPSGPIALLPLSDTLSSLVWSTSHEHAAELVSMDEEEFVDAINSAFWs 224
Cdd:PRK07333 176 KTVGWDYGQSGIVCTVeH--ERPHGGRAEEHFLPAGPFAILPLKGNRSSLVWTERTADAERLVALDDLVFEAELEQRFG- 252

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979303 225 dvHHTDFVdsasamvrhavallkptkvsarqlppsiaKVDAKSRAlFPLGLGHAAEYVRPRVALIGDAAHRIHPLAGQGV 304
Cdd:PRK07333 253 --HRLGEL-----------------------------KVLGKRRA-FPLGLTLARSFVAPRFALVGDAAHGIHPIAGQGL 300

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979303 305 NMGFGDISSLVHHLSTAAFNGKDLGSMSHLTGYETDRQRHNTALLAATDLLKRLYSTSATPLVLLRTWGLQATNAVSPLK 384
Cdd:PRK07333 301 NLGLKDVAALAEVVVEAARLGLDIGSLDVLERYQRWRRFDTVRMGVTTDVLNRLFSNDSTLLRSVRDIGLGLVDRLPKLK 380


                 .
gi 568979303 385 E 385
Cdd:PRK07333 381 S 381
PRK07608 PRK07608
UbiH/UbiF family hydroxylase;
64-392 2.22e-61

UbiH/UbiF family hydroxylase;


Pssm-ID: 181057 [Multi-domain]  Cd Length: 388  Bit Score: 202.49  E-value: 2.22e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979303  64 MGYIVENDVIMYALTKQLeAVADRVKVLYESkavgyswPGAFSMADSSpwVHITLGDGSTLQTKLLIGADGHKSGVRQAA 143
Cdd:PRK07608 104 LAWIVESSLIERALWAAL-RFQPNLTWFPAR-------AQGLEVDPDA--ATLTLADGQVLRADLVVGADGAHSWVRSQA 173

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979303 144 GIQNVSWKYDQSAVVATLhLSEATENNVAWQRFLPSGPIALLPLSDTLSSLVWSTSHEHAAELVSMDEEEFVDAinsafw 223
Cdd:PRK07608 174 GIKAERRPYRQTGVVANF-KAERPHRGTAYQWFRDDGILALLPLPDGHVSMVWSARTAHADELLALSPEALAAR------ 246

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979303 224 sdvhhtdfVDSASAMVRHAVALLKPtkvsarqlppsiakvdaksRALFPLGLGHAAEYVRPRVALIGDAAHRIHPLAGQG 303
Cdd:PRK07608 247 --------VERASGGRLGRLECVTP-------------------AAGFPLRLQRVDRLVAPRVALVGDAAHLIHPLAGQG 299

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979303 304 VNMGFGDISSLVHHL-STAAFngKDLGSMSHLTGYETDRQRHNTALLAATDLLKRLYSTSATPLVLLRTWGLQATNAVSP 382
Cdd:PRK07608 300 MNLGLRDVAALADVLaGREPF--RDLGDLRLLRRYERARREDILALQVATDGLQRLFALPGPLARWLRNAGMALVGALPL 377

                        330
                 ....*....|
gi 568979303 383 LKEQIMAFAS 392
Cdd:PRK07608 378 VKRWLVRHAL 387
UbiH TIGR01984
2-polyprenyl-6-methoxyphenol 4-hydroxylase; This model represents the FAD-dependent ...
 60-387 1.11e-57

2-polyprenyl-6-methoxyphenol 4-hydroxylase; This model represents the FAD-dependent monoxygenase responsible for the second hydroxylation step in the aerobic ubiquinone bioynthetic pathway. The scope of this model is limited to the proteobacteria. This family is closely related to the UbiF hydroxylase which catalyzes the final hydroxylation step. The enzyme has also been named VisB due to a mutant VISible light sensitive phenotype. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273911 [Multi-domain]  Cd Length: 382  Bit Score: 192.91  E-value: 1.11e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979303   60 NLDDMGYIVENDVIMYALTKQLeAVADRVKVLYESKAVGYswpgafsmADSSPWVHITLGDGSTLQTKLLIGADGHKSGV 139
Cdd:TIGR01984  94 GLPALGYVVELADLGQALLSRL-ALLTNIQLYCPARYKEI--------IRNQDYVRVTLDNGQQLRAKLLIAADGANSKV 164

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979303  140 RQAAGIQNVSWKYDQSAVVATLHLSEATENnVAWQRFLPSGPIALLPLSD-TLSSLVWSTSHEHAAELVSMDEEEFVDAI 218
Cdd:TIGR01984 165 RELLSIPTEEHDYNQTALIANIRHEQPHQG-CAFERFTPHGPLALLPLKDnYRSSLVWCLPSKQADTIANLPDAEFLAEL 243

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979303  219 NSAFWSDvhhtdfvdsasamvrhavaLLKPTKVSARQLppsiakvdaksralFPLGLGHAAEYVRPRVALIGDAAHRIHP 298
Cdd:TIGR01984 244 QQAFGWR-------------------LGKITQVGERKT--------------YPLKLRIAETHVHPRVVLIGNAAQTLHP 290

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979303  299 LAGQGVNMGFGDISSLVHHLSTAAfngKDLGSMSHLTGYETDRQRHNTALLAATDLLKRLYSTSATPLVLLRTWGLQATN 378
Cdd:TIGR01984 291 IAGQGFNLGLRDVETLAEVLIDAR---IDLGTYALLQEYLRRRQFDQFITIGLTDGLNRLFSNHIPLLRALRNLGLLALE 367


                  ....*....
gi 568979303  379 AVSPLKEQI 387
Cdd:TIGR01984 368 NFPPLKKRL 376
ubiF PRK08020
2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed
 46-391 1.56e-53

2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed


Pssm-ID: 181199 [Multi-domain]  Cd Length: 391  Bit Score: 182.11  E-value: 1.56e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979303  46 WDScseALIMFDRD--NLDDMGYIVENDVIMYALTKQLEAvADRVKVLYESKAVGYSWpgafsmaDSSPWvHITLGDGST 123
Cdd:PRK08020  88 WET---AHVVFDAAelKLPELGYMVENRVLQLALWQALEA-HPNVTLRCPASLQALQR-------DDDGW-ELTLADGEE 155

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979303 124 LQTKLLIGADGHKSGVRQAAGIQNVSWKYDQSAVVATLHlSEATENNVAWQRFLPSGPIALLPLSDTLSSLVWSTSHEHA 203
Cdd:PRK08020 156 IQAKLVIGADGANSQVRQMAGIGVHGWQYRQSCMLISVK-CENPPGDSTWQQFTPSGPRAFLPLFDNWASLVWYDSPARI 234

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979303 204 AELVSMDEEEFVDAINSAFwsdvhhtdfvdsasamvrhavallkptkvsarqlPPSIAKVDAKSRALFPLGLGHAAEYVR 283
Cdd:PRK08020 235 RQLQAMSMAQLQQEIAAHF----------------------------------PARLGAVTPVAAGAFPLTRRHALQYVQ 280

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979303 284 PRVALIGDAAHRIHPLAGQGVNMGFGDISSLVHHLSTAAFNGKDLGSMSHLTGYETDRQRHNTALLAATDLLKRLYSTSA 363
Cdd:PRK08020 281 PGLALVGDAAHTINPLAGQGVNLGYRDVDALLDVLVNARSYGEAWASEAVLKRYQRRRMADNLLMQSGMDLFYAGFSNNL 360

                        330       340
                 ....*....|....*....|....*...
gi 568979303 364 TPLVLLRTWGLQATNAVSPLKEQIMAFA 391
Cdd:PRK08020 361 PPLRFARNLGLMAAQRAGVLKRQALKYA 388
PRK05732 PRK05732
2-octaprenyl-6-methoxyphenyl hydroxylase; Validated
 60-384 1.43e-52

2-octaprenyl-6-methoxyphenyl hydroxylase; Validated


Pssm-ID: 235584 [Multi-domain]  Cd Length: 395  Bit Score: 179.66  E-value: 1.43e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979303  60 NLDDMGYIVENDVIMYALTKQLEavadrvkvlyesKAVGYSW--PGAF-SMADSSPWVHITLGDGSTLQTKLLIGADGHK 136
Cdd:PRK05732 101 GVPALGYVVELHDVGQRLFALLD------------KAPGVTLhcPARVaNVERTQGSVRVTLDDGETLTGRLLVAADGSH 168

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979303 137 SGVRQAAGIQNVSWKYDQSAVVATLHLSEAtENNVAWQRFLPSGPIALLPLSDTLSSLVWSTSHEHAAELVSMDEEEFVD 216
Cdd:PRK05732 169 SALREALGIDWQQHPYEQVAVIANVTTSEA-HQGRAFERFTEHGPLALLPMSDGRCSLVWCHPLEDAEEVLSWSDAQFLA 247

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979303 217 AINSAF-WSdvhhtdfvdsasamvrhavaLLKPTKVSArqlppsiakvdaksRALFPLGLGHAAEYVRPRVALIGDAAHR 295
Cdd:PRK05732 248 ELQQAFgWR--------------------LGRITHAGK--------------RSAYPLALVTAAQQISHRLALVGNAAQT 293

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979303 296 IHPLAGQGVNMGFGDISSLVHHLSTAAFNGKDLGSMSHLTGYETDRQ--RHNTalLAATDLLKRLYSTSATPLVLLRTWG 373
Cdd:PRK05732 294 LHPIAGQGFNLGLRDVMSLAETLTQALARGEDIGDYAVLQRYQQRRQqdREAT--IGFTDGLVRLFANRWAPLVVGRNLG 371

                        330
                 ....*....|.
gi 568979303 374 LQATNAVSPLK 384
Cdd:PRK05732 372 LMAMDLLPPAR 382
PRK05714 PRK05714
2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Provisional
 45-384 2.10e-50

2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Provisional


Pssm-ID: 168201 [Multi-domain]  Cd Length: 405  Bit Score: 174.25  E-value: 2.10e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979303  45 VWDSCSEALIMFDRDNL--DDMGYIVENDVIMYALtkqLEAVAD-RVKVLYESKAVGYSWPGafsmadsSPWVhITLGDG 121
Cdd:PRK05714  84 VWDGSGTGQIHFSAASVhaEVLGHIVENRVVQDAL---LERLHDsDIGLLANARLEQMRRSG-------DDWL-LTLADG 152

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979303 122 STLQTKLLIGADGHKSGVRQAAGIQNVSWKYDQSAVVATLHLSEAtENNVAWQRFLPSGPIALLPLSDT----LSSLVWS 197
Cdd:PRK05714 153 RQLRAPLVVAADGANSAVRRLAGCATREWDYLHHAIVTSVRCSEP-HRATAWQRFTDDGPLAFLPLERDgdehWCSIVWS 231

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979303 198 TSHEHAAELVSMDEEEFVDAINSAFWSDVHHTdfvdsasamvrhavallkptkvsarqlppsiakVDAKSRALFPLGLGH 277
Cdd:PRK05714 232 TTPEEAERLMALDDDAFCAALERAFEGRLGEV---------------------------------LSADPRLCVPLRQRH 278

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979303 278 AAEYVRPRVALIGDAAHRIHPLAGQGVNMGFGDISSLVHHLSTAAFNGKDLGSMSHLTGYETDRQRHNTALLAATDLLKR 357
Cdd:PRK05714 279 AKRYVEPGLALIGDAAHTIHPLAGQGVNLGFLDAAVLAEVLLHAAERGERLADVRVLSRFERRRMPHNLALMAAMEGFER 358

                        330       340
                 ....*....|....*....|....*..
gi 568979303 358 LYSTSATPLVLLRTWGLQATNAVSPLK 384
Cdd:PRK05714 359 LFQADPLPLRWLRNTGLKLVDQMPEAK 385
PRK08013 PRK08013
oxidoreductase; Provisional
 44-388 1.12e-49

oxidoreductase; Provisional


Pssm-ID: 236139 [Multi-domain]  Cd Length: 400  Bit Score: 172.15  E-value: 1.12e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979303  44 AVWDSCSEALIMFDRDN--LDDMGYIVENDVIMYALTKQLEAVADrVKVLYES--KAVGYSWPGAFsmadsspwvhITLG 119
Cdd:PRK08013  82 EVWDKDSFGRIAFDDQSmgYSHLGHIIENSVIHYALWQKAQQSSD-ITLLAPAelQQVAWGENEAF----------LTLK 150

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979303 120 DGSTLQTKLLIGADGHKSGVRQAAGIQNVSWKYDQSAVVATLHlSEATENNVAWQRFLPSGPIALLPLSD-TLSSLVWST 198
Cdd:PRK08013 151 DGSMLTARLVVGADGANSWLRNKADIPLTFWDYQHHALVATIR-TEEPHDAVARQVFHGDGILAFLPLSDpHLCSIVWSL 229

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979303 199 SHEHAAELVSMDEEEFVDAINSAFwsDVHhtdfvdsasamvrhavaLLKPTKVSARQlppsiakvdaksraLFPLGLGHA 278
Cdd:PRK08013 230 SPEEAQRMQQAPEEEFNRALAIAF--DNR-----------------LGLCELESERQ--------------VFPLTGRYA 276

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979303 279 AEYVRPRVALIGDAAHRIHPLAGQGVNMGFGDISSLVHHLSTAAFNGKDLGSMSHLTGYETDRQRHNTALLAATDLLKRL 358
Cdd:PRK08013 277 RQFAAHRLALVGDAAHTIHPLAGQGVNLGFMDAAELIAELRRLHRQGKDIGQHLYLRRYERSRKHSAALMLAGMQGFRDL 356

                        330       340       350
                 ....*....|....*....|....*....|
gi 568979303 359 YSTSATPLVLLRTWGLQATNAVSPLKEQIM 388
Cdd:PRK08013 357 FAGNNPAKKLLRDIGLKLADTLPGVKPQLI 386
PRK08849 PRK08849
2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Provisional
 56-391 4.33e-47

2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Provisional


Pssm-ID: 181564 [Multi-domain]  Cd Length: 384  Bit Score: 164.94  E-value: 4.33e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979303  56 FDRD--NLDDMGYIVENDVIMYALTKQLEAVaDRVKVLYESKavgyswpgafsMAD---SSPWVHITLGDGSTLQTKLLI 130
Cdd:PRK08849  93 FHSDelNLDQLGYIVENRLIQLGLWQQFAQY-PNLTLMCPEK-----------LADlefSAEGNRVTLESGAEIEAKWVI 160

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979303 131 GADGHKSGVRQAAGIQNVSWKYDQSAVVATLHlSEATENNVAWQRFLPSGPIALLPLSDTLSSLVWSTSHEHAAELVSMD 210
Cdd:PRK08849 161 GADGANSQVRQLAGIGITAWDYRQHCMLINVE-TEQPQQDITWQQFTPSGPRSFLPLCGNQGSLVWYDSPKRIKQLSAMN 239

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979303 211 EEEFVDAInsafwsdvhhtdfvdsasamVRHavallkptkvsarqLPPSIAKVDAKSRALFPLGLGHAAEYVRPRVALIG 290
Cdd:PRK08849 240 PEQLRSEI--------------------LRH--------------FPAELGEIKVLQHGSFPLTRRHAQQYVKNNCVLLG 285

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979303 291 DAAHRIHPLAGQGVNMGFGDISSLVHhlstaAFNGKDLGSMSHLTGYETDRQRHNTALLAATDLLKRLYSTSATPLVLLR 370
Cdd:PRK08849 286 DAAHTINPLAGQGVNLGFKDVDVLLA-----ETEKQGVLNDASFARYERRRRPDNLLMQTGMDLFYKTFSNSLTPLKFVR 360

                        330       340
                 ....*....|....*....|.
gi 568979303 371 TWGLQATNAVSPLKEQIMAFA 391
Cdd:PRK08849 361 NAALKLAENSGPLKTQVLKYA 381
PRK08773 PRK08773
UbiH/UbiF family hydroxylase;
45-383 5.49e-44

UbiH/UbiF family hydroxylase;


Pssm-ID: 181552 [Multi-domain]  Cd Length: 392  Bit Score: 156.95  E-value: 5.49e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979303  45 VWDSCSEALIMFDRDNL--DDMGYIVENDVIMYALTKQLEAVAdrVKVLYESKAVgyswpgafSMADSSPWVHITLGDGS 122
Cdd:PRK08773  85 VWDAGGGGELGFDADTLgrEQLGWIVENDLLVDRLWAALHAAG--VQLHCPARVV--------ALEQDADRVRLRLDDGR 154

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979303 123 TLQTKLLIGADGHKSGVRQAAGIQNVSWKYDQSAVVA---TLHLSEATennvAWQRFLPSGPIALLPLSDTLSSLVWSTS 199
Cdd:PRK08773 155 RLEAALAIAADGAASTLRELAGLPVSRHDYAQRGVVAfvdTEHPHQAT----AWQRFLPTGPLALLPFADGRSSIVWTLP 230

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979303 200 HEHAAELVSMDEEEFVDAINSAFWSDVHHtdfVDSASAmvrhavallkptkvsarqlppsiakvdaksRALFPLGLGHAA 279
Cdd:PRK08773 231 DAEAERVLALDEAAFSRELTQAFAARLGE---VRVASP------------------------------RTAFPLRRQLVQ 277

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979303 280 EYVRPRVALIGDAAHRIHPLAGQGVNMGFGDISSLVHHLSTAAFNGKDLGSMSHLTGYETDRQRHNTALLAATDLLKRLY 359
Cdd:PRK08773 278 QYVSGRVLTLGDAAHVVHPLAGQGVNLGLRDVAALQQLVRQAHARRADWAAPHRLQRWARTRRSDNTVAAYGFDAINRVF 357

                        330       340
                 ....*....|....*....|....
gi 568979303 360 STSATPLVLLRTWGLQATNAVSPL 383
Cdd:PRK08773 358 SNDEMHLTLLRGSVLGLAGKLPPL 381
PRK07494 PRK07494
UbiH/UbiF family hydroxylase;
114-388 6.72e-40

UbiH/UbiF family hydroxylase;


Pssm-ID: 181001 [Multi-domain]  Cd Length: 388  Bit Score: 145.82  E-value: 6.72e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979303 114 VHITLGDGSTLQTKLLIGADGHKSGVRQAAGIQNVSWKYDQSAVV-ATLHlsEATENNVAWQRFLPSGPIALLPLSDTLS 192
Cdd:PRK07494 144 VTVTLADGTTLSARLVVGADGRNSPVREAAGIGVRTWSYPQKALVlNFTH--SRPHQNVSTEFHTEGGPFTQVPLPGRRS 221

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979303 193 SLVWSTSHEHAAELVSMDEEEFvdainsafwsdvhhtdfvdsASAMVRHAVALLKPTKVSARqlppsiakvdaksRALFP 272
Cdd:PRK07494 222 SLVWVVRPAEAERLLALSDAAL--------------------SAAIEERMQSMLGKLTLEPG-------------RQAWP 268

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979303 273 LGLGHAAEYVRPRVALIGDAAHRIHPLAGQGVNMGFGDISSLVhhlSTAAFNGKDLGSMSHLTGYetDRQRHNTALL--A 350
Cdd:PRK07494 269 LSGQVAHRFAAGRTALVGEAAHVFPPIGAQGLNLGLRDVATLV---EIVEDRPEDPGSAAVLAAY--DRARRPDILSrtA 343

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 568979303 351 ATDLLKRLYSTSATPLVLLRTWGLQATNAVSPLKEQIM 388
Cdd:PRK07494 344 SVDLLNRSLLSDFLPVQDLRAAGLHLLYSFGPLRRLFM 381
PRK09126 PRK09126
FAD-dependent hydroxylase;
45-387 5.62e-39

FAD-dependent hydroxylase;


Pssm-ID: 236385 [Multi-domain]  Cd Length: 392  Bit Score: 143.54  E-value: 5.62e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979303  45 VWDSCSEALIMFDRDN--LDDMGYIVENDVIMYALtkqLEAVADRVKV-LYESKAVGYSWPGAfsmadssPWVHITLGDG 121
Cdd:PRK09126  82 VLNGRSPFALTFDARGrgADALGYLVPNHLIRRAA---YEAVSQQDGIeLLTGTRVTAVRTDD-------DGAQVTLANG 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979303 122 STLQTKLLIGADGHKSGVRQAAGIQNVSWKYDQSAVVATLHlSEATENNVAWQRFLPSGPIALLPLSDTLSSLVWSTSHE 201
Cdd:PRK09126 152 RRLTARLLVAADSRFSATRRQLGIGADMHDFGRTMLVCRMR-HELPHHHTAWEWFGYGQTLALLPLNGHLSSLVLTLPPD 230

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979303 202 HAAELVSMDEEEFVDAInsafwsdvhhtdfvdsaSAMVRHAVALLKPtkvsarqlppsiakvdAKSRALFPLGLGHAAEY 281
Cdd:PRK09126 231 QIEALLALDPEAFAAEV-----------------TARFKGRLGAMRL----------------VSSRHAYPLVAVYAHRF 277

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979303 282 VRPRVALIGDAAHRIHPLAGQGVNMGFGDISSLVHHLSTAAFNGKDLGSMSHLTGYETDRQRHNTALLAATDLLKRLYST 361
Cdd:PRK09126 278 VAKRFALIGDAAVGMHPVTAHGFNLGLKGQDILARLILAAARRGQDIGAASLLERYERKHRLATRPLYHATNAIAALYTD 357

                        330       340
                 ....*....|....*....|....*.
gi 568979303 362 SATPLVLLRTWGLQATNAVSPLKEQI 387
Cdd:PRK09126 358 DRPPARLLRRAVLRAANRFPPLKQAI 383
UbiH COG0654
2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme ...
 65-384 1.99e-34

2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme transport and metabolism, Energy production and conversion]; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 440419 [Multi-domain]  Cd Length: 326  Bit Score: 129.67  E-value: 1.99e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979303  65 GYIVENDVIMYALTKQLEAvaDRVKVLYESKAVGYSWPGAFsmadsspwVHITLGDGSTLQTKLLIGADGHKSGVRQAAG 144
Cdd:COG0654   98 GLVVPRADLERALLEAARA--LGVELRFGTEVTGLEQDADG--------VTVTLADGRTLRADLVVGADGARSAVRRLLG 167

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979303 145 IQNVSWKYDQSAVVATLHLseatennvawqrflpsgpiallplsdtlsslvwstshehaaelvsmdeeEFVDAINSAFWs 224
Cdd:COG0654  168 IGFTGRDYPQRALWAGVRT-------------------------------------------------ELRARLAAAGP- 197

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979303 225 dvhhtdfvdsasamvrHAVALLkptkvsarqlppsiakvDAKSRALFPLGLGHAAEYVRPRVALIGDAAHRIHPLAGQGV 304
Cdd:COG0654  198 ----------------RLGELL-----------------ELSPRSAFPLRRRRAERWRRGRVVLLGDAAHTMHPLGGQGA 244

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979303 305 NMGFGDISSLVHHLStAAFNGKDLGSMshLTGYETDRQRHNTALLAATDLLKRLYSTSATPLVLLRTWGLQATNAVSPLK 384
Cdd:COG0654  245 NLALRDAAALAWKLA-AALRGRDDEAA--LARYERERRPRAARVQRAADALGRLFHPDSPPLRLLRNAGLRLLDRLPPLK 321
PRK06996 PRK06996
UbiH/UbiF/VisC/COQ6 family ubiquinone biosynthesis hydroxylase;
123-387 1.82e-32

UbiH/UbiF/VisC/COQ6 family ubiquinone biosynthesis hydroxylase;


Pssm-ID: 235905 [Multi-domain]  Cd Length: 398  Bit Score: 125.96  E-value: 1.82e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979303 123 TLQTKLLIGADGHK-SGVRQAAGIQNVSWKYDQSAVVATLHLSeATENNVAWQRFLPSGPIALLPLSDTLS---SLVWST 198
Cdd:PRK06996 160 TLRARIAVQAEGGLfHDQKADAGDSARRRDYGQTAIVGTVTVS-APRPGWAWERFTHEGPLALLPLGGPRQadyALVWCC 238

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979303 199 SHEHAAELVSMDEEEFVDAINSAFwsdvhhtdfvdsASAMVRHavallkptkvsarqlppsiakVDAKSRALFPLGLGHA 278
Cdd:PRK06996 239 APDEAARRAALPDDAFLAELGAAF------------GTRMGRF---------------------TRIAGRHAFPLGLNAA 285

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979303 279 AEYVRPRVALIGDAAHRIHPLAGQGVNMGFGDISSLVHHLSTAAFNGKDLGSMSHltgyetdRQRHNTALLA-ATDLLKR 357
Cdd:PRK06996 286 RTLVNGRIAAVGNAAQTLHPVAGQGLNLGLRDAHTLADALSDHGATPLALATFAA-------RRALDRRVTIgATDLLPR 358

                        250       260       270
                 ....*....|....*....|....*....|
gi 568979303 358 LYSTSATPLVLLRTWGLQATNAVSPLKEQI 387
Cdd:PRK06996 359 LFTVDSRPLAHLRGAALTALEFVPPLKHAL 388
PRK06617 PRK06617
2-octaprenyl-6-methoxyphenyl hydroxylase; Validated
 120-391 2.63e-27

2-octaprenyl-6-methoxyphenyl hydroxylase; Validated


Pssm-ID: 168629 [Multi-domain]  Cd Length: 374  Bit Score: 111.17  E-value: 2.63e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979303 120 DGSTLQTKLLIGADGHKSGVRQAAGIQNVSWKYDQSAVVATLHlsEATENNVAWQRFLPSGPIALLPLSDTL-SSLVWST 198
Cdd:PRK06617 143 DDKQIKCNLLIICDGANSKVRSHYFANEIEKPYQTALTFNIKH--EKPHENCAMEHFLPLGPFALLPLKDQYaSSVIWST 220

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979303 199 SHEHAAELVSMDEEEfvdainsafwsdvhhtdfvdsasamVRHavallkptkVSARQLPPSIAKVDAKSR-ALFPLGLGH 277
Cdd:PRK06617 221 SSDQAALIVNLPVEE-------------------------VRF---------LTQRNAGNSLGKITIDSEiSSFPLKARI 266

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979303 278 AAEYVRPRVALIGDAAHRIHPLAGQGVNMGFGDISSLVHHLSTaafNGKdlgsmshLTGYETDRQRHNTALLAATDLLKR 357
Cdd:PRK06617 267 ANRYFHNRIVLIADTAHTVHPLAGQGLNQGIKDIEILSMIVSN---NGT-------LQEYQKLRQEDNFIMYKLTDELNN 336

                        250       260       270
                 ....*....|....*....|....*....|....
gi 568979303 358 LYSTSATPLVLLRTWGLQATNAVSPLKEQIMAFA 391
Cdd:PRK06617 337 IFSNYSKNLRCLRQIGFKVINNFKPIKNLITSYA 370
PRK06834 PRK06834
hypothetical protein; Provisional
 114-310 1.03e-10

hypothetical protein; Provisional


Pssm-ID: 235870 [Multi-domain]  Cd Length: 488  Bit Score: 63.11  E-value: 1.03e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979303 114 VHITLGDGSTLQTKLLIGADGHKSGVRQAAGIQNVSWKYDQSAVVATLHLSEATENNV--------AWQRFLPSGPIAll 185
Cdd:PRK06834 133 VDVELSDGRTLRAQYLVGCDGGRSLVRKAAGIDFPGWDPTTSYLIAEVEMTEEPEWGVhrdalgihAFGRLEDEGPVR-- 210

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979303 186 plsdtlssLVWSTSHEHAAELVSMDeeEFVDAINSAFWSD--VHHTDFVDSASAMvrhavallkptkvsARQlppsiakv 263
Cdd:PRK06834 211 --------VMVTEKQVGATGEPTLD--DLREALIAVYGTDygIHSPTWISRFTDM--------------ARQ-------- 258

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 568979303 264 daksralfplglghAAEYVRPRVALIGDAAHRIHPLAGQGVNMGFGD 310
Cdd:PRK06834 259 --------------AASYRDGRVLLAGDAAHVHSPVGGQGLNTGVQD 291
FAD_binding_3 pfam01494
FAD binding domain; This domain is involved in FAD binding in a number of enzymes.
 119-352 1.10e-09

FAD binding domain; This domain is involved in FAD binding in a number of enzymes.


Pssm-ID: 396193 [Multi-domain]  Cd Length: 348  Bit Score: 59.26  E-value: 1.10e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979303  119 GDGSTLQTKLLIGADGHKSGVRQAAGIQNVSWKYDQSAVVATLHLS------EATENNVAWQRFLPSGPIALLPLSDTLS 192
Cdd:pfam01494 143 GEEYTVRAKYLVGCDGGRSPVRKTLGIEFEGFEGVPFGSLDVLFDApdlsdpVERAFVHYLIYAPHSRGFMVGPWRSAGR 222

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979303  193 S---LVWSTSHEHAAELVSMDEEEFVDAINSAfwsdvHHTDFVDsasamvrhavallkptkvsarqlppsiAKVDAKSRa 269
Cdd:pfam01494 223 EryyVQVPWDEEVEERPEEFTDEELKQRLRSI-----VGIDLAL---------------------------VEILWKSI- 269

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979303  270 lFPLGLGHAAEYVRPRVALIGDAAHRIHPLAGQGVNMGFGDISSLVHHLStAAFNGKdlGSMSHLTGYETDRQRHNTALL 349
Cdd:pfam01494 270 -WGVASRVATRYRKGRVFLAGDAAHIHPPTGGQGLNTAIQDAFNLAWKLA-AVLRGQ--AGESLLDTYSAERLPVAWAVV 345


                  ...
gi 568979303  350 AAT 352
Cdd:pfam01494 346 DFA 348
PRK07045 PRK07045
putative monooxygenase; Reviewed
 116-350 2.88e-09

putative monooxygenase; Reviewed


Pssm-ID: 136171 [Multi-domain]  Cd Length: 388  Bit Score: 58.38  E-value: 2.88e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979303 116 ITLGDGSTLQTKLLIGADGHKSGVRQ-AAGIQNVSWKYDQSAVVATLHLSEAT-ENNvawQRFLPS--GPIALLPLSDTL 191
Cdd:PRK07045 144 VTLSDGERVAPTVLVGADGARSMIRDdVLRMPAERVPYATPMAFGTIALTDSVrECN---RLYVDSnqGLAYFYPIGDQA 220

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979303 192 SSLVWSTSHEHAAELVSMDEEEFVDAINSAFWSDvhhtdfvDSASAMvrhavallkptkvsarqlppsiAKVDAKSR-AL 270
Cdd:PRK07045 221 TRLVVSFPADEMQGYLADTTRTKLLARLNEFVGD-------ESADAM----------------------AAIGAGTAfPL 271

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979303 271 FPLGLGHAAEYVRPRVALIGDAAHRIHPLAGQGVNMGFGDISSLVHHLSTAAFNGKDLGSMshLTGYETDRQRHNTALLA 350
Cdd:PRK07045 272 IPLGRMNLDRYHKRNVVLLGDAAHSIHPITGQGMNLAIEDAGELGACLDLHLSGQIALADA--LERFERIRRPVNEAVIS 349
PRK08244 PRK08244
monooxygenase;
122-390 2.62e-08

monooxygenase;


Pssm-ID: 236199 [Multi-domain]  Cd Length: 493  Bit Score: 55.52  E-value: 2.62e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979303 122 STLQTKLLIGADGHKSGVRQAAGIQNVSWKYDQSAVVATLHLSEATENNVAwQRFLPSGPIALLPLSDTLSSLVWSTSHE 201
Cdd:PRK08244 144 RTLTSSYVVGADGAGSIVRKQAGIAFPGTDATFTAMLGDVVLKDPPPSSVL-SLCTREGGVMIVPLSGGIYRVLIIDPER 222

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979303 202 HAA---ELVSmdEEEFVDAInsafwSDVHHTDF-VDSASAMVRHAVAllkptkvsARQlppsiakvdaksralfplglgh 277
Cdd:PRK08244 223 PQVpkdEPVT--LEELKTSL-----IRICGTDFgLNDPVWMSRFGNA--------TRQ---------------------- 265

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979303 278 AAEYVRPRVALIGDAAHrIH-PLAGQGVNMGFGDISSLVHHLStAAFNGKDLGSMshLTGYETDRQRHNTALLAATDLLK 356
Cdd:PRK08244 266 AERYRSGRIFLAGDAAH-IHfPAGGQGLNVGLQDAMNLGWKLA-AAIKGWAPDWL--LDSYHAERHPVGTALLRNTEVQT 341

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 568979303 357 RL--YSTSATPLVLLRTWGLQATNAVSPLKEQIMAF 390
Cdd:PRK08244 342 KLfdFTRPGLALRSMLSDLLGFPEVNRYLAGQISAL 377
mhpA PRK06183
bifunctional 3-(3-hydroxy-phenyl)propionate/3-hydroxycinnamic acid hydroxylase;
278-372 1.14e-03

bifunctional 3-(3-hydroxy-phenyl)propionate/3-hydroxycinnamic acid hydroxylase;


Pssm-ID: 235727 [Multi-domain]  Cd Length: 500  Bit Score: 41.05  E-value: 1.14e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979303 278 AAEYVRPRVALIGDAAHRIHPLAGQGVNMGFGDISSLVHHLStAAFNGK---DLgsmshLTGYETDRQRHNTALLAATDL 354
Cdd:PRK06183 280 ADRWRSGRVLLAGDAAHLMPPFAGQGMNSGIRDAANLAWKLA-AVLRGRagdAL-----LDTYEQERRPHARAMIDLAVR 353

                         90
                 ....*....|....*...
gi 568979303 355 LKRLYSTSATPLVLLRTW 372
Cdd:PRK06183 354 LGRVICPTDRLAAALRDA 371
FixC COG0644
Dehydrogenase (flavoprotein) [Energy production and conversion];
55-157 2.89e-03

Dehydrogenase (flavoprotein) [Energy production and conversion];


Pssm-ID: 440409 [Multi-domain]  Cd Length: 281  Bit Score: 39.18  E-value: 2.89e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979303  55 MFDRDNLDDmgyivendvimyALTKQleAVADRVKVLYESKAVGYSWPGAfsmadsspWVHITLGDGSTLQTKLLIGADG 134
Cdd:COG0644   82 VVDRARFDR------------WLAEQ--AEEAGAEVRTGTRVTDVLRDDG--------RVVVRTGDGEEIRADYVVDADG 139

                         90       100
                 ....*....|....*....|...
gi 568979303 135 HKSGVRQAAGIQNVSWKYDQSAV 157
Cdd:COG0644  140 ARSLLARKLGLKRRSDEPQDYAL 162
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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