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Conserved domains on  [gi|568979868|ref|XP_006516039|]
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echinoderm microtubule-associated protein-like 5 isoform X8 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
605-992 5.53e-31

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 126.95  E-value: 5.53e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979868  605 LTVNQHPKFINIVATGQVGDSADMSATAPSVHIWDAVNKQTLSILRcSHSKGVCSVSFSATGKLLLSVGLDpeHTVTIWR 684
Cdd:COG2319    72 ATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLT-GHTGAVRSVAFSPDGKTLASGSAD--GTVRLWD 148

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979868  685 WQEGAKIASRGGHNQRIFVAEFRPDSdTQFVSVGI-KHVKFWTLA-GRALLSKKGLLSSLedarmqtmLAVAFGANNLTF 762
Cdd:COG2319   149 LATGKLLRTLTGHSGAVTSVAFSPDG-KLLASGSDdGTVRLWDLAtGKLLRTLTGHTGAV--------RSVAFSPDGKLL 219

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979868  763 -TGTISGDVCVWK-DHILCRVVARAHNGPVFAMyTTLRDG-LIVTGGkerpskEGGAVKLWDqelrrcrafrLETGQvtd 839
Cdd:COG2319   220 aSGSADGTVRLWDlATGKLLRTLTGHSGSVRSV-AFSPDGrLLASGS------ADGTVRLWD----------LATGE--- 279

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979868  840 CVRSVcrgkgkilvgtrnseiievgeknaacnilvnGHVDGPIWGLATHPSRDFFLSAAEDGTVRLWDIADKKMLNKVNl 919
Cdd:COG2319   280 LLRTL-------------------------------TGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLT- 327

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568979868  920 GHAA--RTVCYSPEGDMVAIGMKNGEFIILLVSSLKIWGKKRDRRCAIHDIRFSPDSRYLAVGSSENSVDFYDLT 992
Cdd:COG2319   328 GHTGavRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
57-317 6.72e-26

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 111.54  E-value: 6.72e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979868   57 SGTSTGDVCIW--RDVFLVKTVKAHDGPVFSM--HALEKGFVTGGKDGMVALWDDSFERCLKTyaikradlapgskglLL 132
Cdd:COG2319   137 SGSADGTVRLWdlATGKLLRTLTGHSGAVTSVafSPDGKLLASGSDDGTVRLWDLATGKLLRT---------------LT 201

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979868  133 EDNPSIRAISLGH-GHILV-GTKNGEILEVD-KSGPITLLVQGHmEGEVWGLATHPYLPICATVSDDKTLRIWDLSPSHC 209
Cdd:COG2319   202 GHTGAVRSVAFSPdGKLLAsGSADGTVRLWDlATGKLLRTLTGH-SGSVRSVAFSPDGRLLASGSADGTVRLWDLATGEL 280

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979868  210 MLAVRKLKKGGRCCCFSPDGKALAVGLNDGSFLMANADTLEDLVSFHHRKDIISDIRFSPgSGKYLAVASHDSFVDIYNV 289
Cdd:COG2319   281 LRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKTLASGSDDGTVRLWDL 359

                         250       260
                  ....*....|....*....|....*...
gi 568979868  290 TSSKRVGVCKGATSYITHIDWDSRGKLL 317
Cdd:COG2319   360 ATGELLRTLTGHTGAVTSVAFSPDGRTL 387
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 874-1147 6.51e-18

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 85.46  E-value: 6.51e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979868  874 VNGHvDGPIWGLATHPSRDFFLSAAEDGTVRLWDIADKKMLnKVNLGHAA--RTVCYSPEGDMVAIGMKNGefiillvsS 951
Cdd:cd00200     5 LKGH-TGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELL-RTLKGHTGpvRDVAASADGTYLASGSSDK--------T 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979868  952 LKIWgKKRDRRC---------AIHDIRFSPDSRYLAVGSSENSVDFYDLTLGPTLNRISYCKDipsFVIQMDFSADSRHl 1022
Cdd:cd00200    75 IRLW-DLETGECvrtltghtsYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTD---WVNSVAFSPDGTF- 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979868 1023 qVSSGCYKR--HVYEVPSGKHlvdhaaidritwatwtsilgdevmgIWSRHAEKADVTCACVSHSGISLVTGDDFGMVKL 1100
Cdd:cd00200   150 -VASSSQDGtiKLWDLRTGKC-------------------------VATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKL 203

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 568979868 1101 YDfpcPEKFAKHKRFLGHSPHVTNIRFtSGDRHVVSAGGDDCSLFVW 1147
Cdd:cd00200   204 WD---LSTGKCLGTLRGHENGVNSVAF-SPDGYLLASGSEDGTIRVW 246
HELP super family cl04081
HELP motif; The founding member of the EMAP protein family is the 75 kDa Echinoderm ...
 540-587 8.44e-14

HELP motif; The founding member of the EMAP protein family is the 75 kDa Echinoderm Microtubule-Associated Protein, so-named for its abundance in sea urchin, sand dollar and starfish eggs. The Hydrophobic EMAP-Like Protein (HELP) motif was identified initially in the human EMAP-Like Protein 2 (EML2) and subsequently in the entire EMAP Protein family. The HELP motif is approximately 60-70 amino acids in length and is conserved amongst metazoans. Although the HELP motif is hydrophobic, there is no evidence that EMAP-Like Proteins are membrane-associated. All members of the EMAP-Like Protein family, identified to-date, are constructed with an amino terminal HELP motif followed by a WD domain. In C. elegans, EMAP-Like Protein-1 (ELP-1) is required for touch sensation indicating that ELP-1 may play a role in mechanosensation. The localization of ELP-1 to microtubules and adhesion sites implies that ELP-1 may transmit forces between the body surface and the touch receptor neurons.


The actual alignment was detected with superfamily member pfam03451:

Pssm-ID: 460922  Cd Length: 72  Bit Score: 67.19  E-value: 8.44e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 568979868   540 KKKRPIEDLVLELAFGYRGRDCRNNVHYLNDGdDIIYHTASIGILHNV 587
Cdd:pfam03451   26 KKEPPDKKLKLEWVYGYRGKDCRSNLYYLPTG-EIVYFTAAVVVLYDV 72
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
605-992 5.53e-31

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 126.95  E-value: 5.53e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979868  605 LTVNQHPKFINIVATGQVGDSADMSATAPSVHIWDAVNKQTLSILRcSHSKGVCSVSFSATGKLLLSVGLDpeHTVTIWR 684
Cdd:COG2319    72 ATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLT-GHTGAVRSVAFSPDGKTLASGSAD--GTVRLWD 148

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979868  685 WQEGAKIASRGGHNQRIFVAEFRPDSdTQFVSVGI-KHVKFWTLA-GRALLSKKGLLSSLedarmqtmLAVAFGANNLTF 762
Cdd:COG2319   149 LATGKLLRTLTGHSGAVTSVAFSPDG-KLLASGSDdGTVRLWDLAtGKLLRTLTGHTGAV--------RSVAFSPDGKLL 219

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979868  763 -TGTISGDVCVWK-DHILCRVVARAHNGPVFAMyTTLRDG-LIVTGGkerpskEGGAVKLWDqelrrcrafrLETGQvtd 839
Cdd:COG2319   220 aSGSADGTVRLWDlATGKLLRTLTGHSGSVRSV-AFSPDGrLLASGS------ADGTVRLWD----------LATGE--- 279

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979868  840 CVRSVcrgkgkilvgtrnseiievgeknaacnilvnGHVDGPIWGLATHPSRDFFLSAAEDGTVRLWDIADKKMLNKVNl 919
Cdd:COG2319   280 LLRTL-------------------------------TGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLT- 327

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568979868  920 GHAA--RTVCYSPEGDMVAIGMKNGEFIILLVSSLKIWGKKRDRRCAIHDIRFSPDSRYLAVGSSENSVDFYDLT 992
Cdd:COG2319   328 GHTGavRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
57-317 6.72e-26

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 111.54  E-value: 6.72e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979868   57 SGTSTGDVCIW--RDVFLVKTVKAHDGPVFSM--HALEKGFVTGGKDGMVALWDDSFERCLKTyaikradlapgskglLL 132
Cdd:COG2319   137 SGSADGTVRLWdlATGKLLRTLTGHSGAVTSVafSPDGKLLASGSDDGTVRLWDLATGKLLRT---------------LT 201

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979868  133 EDNPSIRAISLGH-GHILV-GTKNGEILEVD-KSGPITLLVQGHmEGEVWGLATHPYLPICATVSDDKTLRIWDLSPSHC 209
Cdd:COG2319   202 GHTGAVRSVAFSPdGKLLAsGSADGTVRLWDlATGKLLRTLTGH-SGSVRSVAFSPDGRLLASGSADGTVRLWDLATGEL 280

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979868  210 MLAVRKLKKGGRCCCFSPDGKALAVGLNDGSFLMANADTLEDLVSFHHRKDIISDIRFSPgSGKYLAVASHDSFVDIYNV 289
Cdd:COG2319   281 LRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKTLASGSDDGTVRLWDL 359

                         250       260
                  ....*....|....*....|....*...
gi 568979868  290 TSSKRVGVCKGATSYITHIDWDSRGKLL 317
Cdd:COG2319   360 ATGELLRTLTGHTGAVTSVAFSPDGRTL 387
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 72-317 7.85e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 94.32  E-value: 7.85e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979868   72 LVKTVKAHDGPVFSMHALEKG--FVTGGKDGMVALWD---DSFERCLKTYAIKRADLAPGSKGLLLednpsiraislghg 146
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGklLATGSGDGTIKVWDletGELLRTLKGHTGPVRDVAASADGTYL-------------- 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979868  147 hiLVGTKNGEILEVD-KSGPITLLVQGHmEGEVWGLATHPYLPICATVSDDKTLRIWDLSPSHCMLAVRKLKKGGRCCCF 225
Cdd:cd00200    67 --ASGSSDKTIRLWDlETGECVRTLTGH-TSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAF 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979868  226 SPDGKALAVGLNDGSFLMANADTLEDLVSFHHRKDIISDIRFSPgSGKYLAVASHDSFVDIYNVTSSKRVGVCKGATSYI 305
Cdd:cd00200   144 SPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSP-DGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGV 222

                         250
                  ....*....|..
gi 568979868  306 THIDWDSRGKLL 317
Cdd:cd00200   223 NSVAFSPDGYLL 234
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 595-955 1.46e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 93.55  E-value: 1.46e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979868  595 YQEHNDDILCLTVNQHPKFInivATGqvgdSADmsataPSVHIWDAVNKQTLSILrCSHSKGVCSVSFSATGKLLLSVGL 674
Cdd:cd00200     5 LKGHTGGVTCVAFSPDGKLL---ATG----SGD-----GTIKVWDLETGELLRTL-KGHTGPVRDVAASADGTYLASGSS 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979868  675 DpeHTVTIWRWQEGAKIASRGGHNQRIFVAEFRPDSDTqfvsvgikhvkfwtlagrallskkgLLSSLEDarmqtmlava 754
Cdd:cd00200    72 D--KTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRI-------------------------LSSSSRD---------- 114

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979868  755 fgannltftgtisGDVCVWK-DHILCRVVARAHNGPVFAMyTTLRDGLIVTGgkerpSKEGGAVKLWD-QELRRCRAFRL 832
Cdd:cd00200   115 -------------KTIKVWDvETGKCLTTLRGHTDWVNSV-AFSPDGTFVAS-----SSQDGTIKLWDlRTGKCVATLTG 175

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979868  833 ETGQVTDCvrSVCRGKGKILVGTRNSEIIEVGEKNAACNILVNGHvDGPIWGLATHPSRDFFLSAAEDGTVRLWDIADKK 912
Cdd:cd00200   176 HTGEVNSV--AFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGH-ENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGE 252

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*
gi 568979868  913 MLNKVNlGHAAR--TVCYSPEGDMVAIGMKNGefiillvsSLKIW 955
Cdd:cd00200   253 CVQTLS-GHTNSvtSLAWSPDGKRLASGSADG--------TIRIW 288
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 874-1147 6.51e-18

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 85.46  E-value: 6.51e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979868  874 VNGHvDGPIWGLATHPSRDFFLSAAEDGTVRLWDIADKKMLnKVNLGHAA--RTVCYSPEGDMVAIGMKNGefiillvsS 951
Cdd:cd00200     5 LKGH-TGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELL-RTLKGHTGpvRDVAASADGTYLASGSSDK--------T 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979868  952 LKIWgKKRDRRC---------AIHDIRFSPDSRYLAVGSSENSVDFYDLTLGPTLNRISYCKDipsFVIQMDFSADSRHl 1022
Cdd:cd00200    75 IRLW-DLETGECvrtltghtsYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTD---WVNSVAFSPDGTF- 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979868 1023 qVSSGCYKR--HVYEVPSGKHlvdhaaidritwatwtsilgdevmgIWSRHAEKADVTCACVSHSGISLVTGDDFGMVKL 1100
Cdd:cd00200   150 -VASSSQDGtiKLWDLRTGKC-------------------------VATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKL 203

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 568979868 1101 YDfpcPEKFAKHKRFLGHSPHVTNIRFtSGDRHVVSAGGDDCSLFVW 1147
Cdd:cd00200   204 WD---LSTGKCLGTLRGHENGVNSVAF-SPDGYLLASGSEDGTIRVW 246
HELP pfam03451
HELP motif; The founding member of the EMAP protein family is the 75 kDa Echinoderm ...
 540-587 8.44e-14

HELP motif; The founding member of the EMAP protein family is the 75 kDa Echinoderm Microtubule-Associated Protein, so-named for its abundance in sea urchin, sand dollar and starfish eggs. The Hydrophobic EMAP-Like Protein (HELP) motif was identified initially in the human EMAP-Like Protein 2 (EML2) and subsequently in the entire EMAP Protein family. The HELP motif is approximately 60-70 amino acids in length and is conserved amongst metazoans. Although the HELP motif is hydrophobic, there is no evidence that EMAP-Like Proteins are membrane-associated. All members of the EMAP-Like Protein family, identified to-date, are constructed with an amino terminal HELP motif followed by a WD domain. In C. elegans, EMAP-Like Protein-1 (ELP-1) is required for touch sensation indicating that ELP-1 may play a role in mechanosensation. The localization of ELP-1 to microtubules and adhesion sites implies that ELP-1 may transmit forces between the body surface and the touch receptor neurons.


Pssm-ID: 460922  Cd Length: 72  Bit Score: 67.19  E-value: 8.44e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 568979868   540 KKKRPIEDLVLELAFGYRGRDCRNNVHYLNDGdDIIYHTASIGILHNV 587
Cdd:pfam03451   26 KKEPPDKKLKLEWVYGYRGKDCRSNLYYLPTG-EIVYFTAAVVVLYDV 72
WD40 COG2319
WD40 repeat [General function prediction only];
886-1147 5.58e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 59.54  E-value: 5.58e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979868  886 ATHPSRDFFLSAAEDGTVRLWDIADKKMLNKVNLGHAARTVC-YSPEGDMVAIGMKNGEFIILLVSSLKIWGKKRDRRCA 964
Cdd:COG2319     1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLaASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979868  965 IHDIRFSPDSRYLAVGSSENSVDFYDLTLGPTLNRIsycKDIPSFVIQMDFSADSRHLqVSSGCYKR-HVYEVPSGKH-- 1041
Cdd:COG2319    81 VLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTL---TGHTGAVRSVAFSPDGKTL-ASGSADGTvRLWDLATGKLlr 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979868 1042 -LVDHA-AIDRITWA----TWTSILGDEVMGIWSRHAEK---------ADVTCACVSHSGISLVTGDDFGMVKLYDfpcP 1106
Cdd:COG2319   157 tLTGHSgAVTSVAFSpdgkLLASGSDDGTVRLWDLATGKllrtltghtGAVRSVAFSPDGKLLASGSADGTVRLWD---L 233

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 568979868 1107 EKFAKHKRFLGHSPHVTNIRFTSGDRHVVSAGGDDcSLFVW 1147
Cdd:COG2319   234 ATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADG-TVRLW 273
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 926-1008 9.56e-06

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 44.96  E-value: 9.56e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979868   926 VCYSPEGDMVAIGMKNGEFIILLVSSLKIWGKKRDRR-CAIHDIRFSPDSRYLAVGSSENSVDFYDLTLGPTLNRISYCK 1004
Cdd:pfam12894    1 MSWCPTMDLIALATEDGELLLHRLNWQRVWTLSPDKEdLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGS 80


                   ....
gi 568979868  1005 DIPS 1008
Cdd:pfam12894   81 DLIT 84
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 875-907 3.38e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.22  E-value: 3.38e-04
                            10        20        30
                    ....*....|....*....|....*....|...
gi 568979868    875 NGHvDGPIWGLATHPSRDFFLSAAEDGTVRLWD 907
Cdd:smart00320    9 KGH-TGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 171-203 2.54e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.52  E-value: 2.54e-03
                            10        20        30
                    ....*....|....*....|....*....|...
gi 568979868    171 QGHmEGEVWGLATHPYLPICATVSDDKTLRIWD 203
Cdd:smart00320    9 KGH-TGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
171-203 9.65e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.01  E-value: 9.65e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 568979868   171 QGHmEGEVWGLATHPYLPICATVSDDKTLRIWD 203
Cdd:pfam00400    8 EGH-TGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
605-992 5.53e-31

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 126.95  E-value: 5.53e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979868  605 LTVNQHPKFINIVATGQVGDSADMSATAPSVHIWDAVNKQTLSILRcSHSKGVCSVSFSATGKLLLSVGLDpeHTVTIWR 684
Cdd:COG2319    72 ATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLT-GHTGAVRSVAFSPDGKTLASGSAD--GTVRLWD 148

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979868  685 WQEGAKIASRGGHNQRIFVAEFRPDSdTQFVSVGI-KHVKFWTLA-GRALLSKKGLLSSLedarmqtmLAVAFGANNLTF 762
Cdd:COG2319   149 LATGKLLRTLTGHSGAVTSVAFSPDG-KLLASGSDdGTVRLWDLAtGKLLRTLTGHTGAV--------RSVAFSPDGKLL 219

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979868  763 -TGTISGDVCVWK-DHILCRVVARAHNGPVFAMyTTLRDG-LIVTGGkerpskEGGAVKLWDqelrrcrafrLETGQvtd 839
Cdd:COG2319   220 aSGSADGTVRLWDlATGKLLRTLTGHSGSVRSV-AFSPDGrLLASGS------ADGTVRLWD----------LATGE--- 279

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979868  840 CVRSVcrgkgkilvgtrnseiievgeknaacnilvnGHVDGPIWGLATHPSRDFFLSAAEDGTVRLWDIADKKMLNKVNl 919
Cdd:COG2319   280 LLRTL-------------------------------TGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLT- 327

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568979868  920 GHAA--RTVCYSPEGDMVAIGMKNGEFIILLVSSLKIWGKKRDRRCAIHDIRFSPDSRYLAVGSSENSVDFYDLT 992
Cdd:COG2319   328 GHTGavRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
679-1147 6.18e-28

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 117.70  E-value: 6.18e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979868  679 TVTIWRWQEGAKIASRGGHNQRIFVAEFRPDSDTQFVSVGIKHVKFWTLAGRALLSKKGLLSSledarmqTMLAVAFGAN 758
Cdd:COG2319    17 ALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTA-------AVLSVAFSPD 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979868  759 NLTF-TGTISGDVCVWK-DHILCRVVARAHNGPVFAMyTTLRDG-LIVTGGkerpskEGGAVKLWDqelrrcrafrLETG 835
Cdd:COG2319    90 GRLLaSASADGTVRLWDlATGLLLRTLTGHTGAVRSV-AFSPDGkTLASGS------ADGTVRLWD----------LATG 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979868  836 QvtdcvrsvcrgkgkiLVGTrnseiievgeknaacnilVNGHvDGPIWGLATHPSRDFFLSAAEDGTVRLWDIADKKMLN 915
Cdd:COG2319   153 K---------------LLRT------------------LTGH-SGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLR 198

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979868  916 KVNlGHAA--RTVCYSPEGDMVAIGMKNGEFIILLVSSLKIWGKKRDRRCAIHDIRFSPDSRYLAVGSSENSVDFYDLTL 993
Cdd:COG2319   199 TLT-GHTGavRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLAT 277

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979868  994 GPTLNRIsycKDIPSFVIQMDFSADSRHLqVSSGCYKR-HVYEVPSGKHLVDHAAidritwatwtsilgdevmgiwsrha 1072
Cdd:COG2319   278 GELLRTL---TGHSGGVNSVAFSPDGKLL-ASGSDDGTvRLWDLATGKLLRTLTG------------------------- 328

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568979868 1073 EKADVTCACVSHSGISLVTGDDFGMVKLYDfpcPEKFAKHKRFLGHSPHVTNIRFTSGDRHVVSaGGDDCSLFVW 1147
Cdd:COG2319   329 HTGAVRSVAFSPDGKTLASGSDDGTVRLWD---LATGELLRTLTGHTGAVTSVAFSPDGRTLAS-GSADGTVRLW 399
WD40 COG2319
WD40 repeat [General function prediction only];
57-317 6.72e-26

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 111.54  E-value: 6.72e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979868   57 SGTSTGDVCIW--RDVFLVKTVKAHDGPVFSM--HALEKGFVTGGKDGMVALWDDSFERCLKTyaikradlapgskglLL 132
Cdd:COG2319   137 SGSADGTVRLWdlATGKLLRTLTGHSGAVTSVafSPDGKLLASGSDDGTVRLWDLATGKLLRT---------------LT 201

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979868  133 EDNPSIRAISLGH-GHILV-GTKNGEILEVD-KSGPITLLVQGHmEGEVWGLATHPYLPICATVSDDKTLRIWDLSPSHC 209
Cdd:COG2319   202 GHTGAVRSVAFSPdGKLLAsGSADGTVRLWDlATGKLLRTLTGH-SGSVRSVAFSPDGRLLASGSADGTVRLWDLATGEL 280

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979868  210 MLAVRKLKKGGRCCCFSPDGKALAVGLNDGSFLMANADTLEDLVSFHHRKDIISDIRFSPgSGKYLAVASHDSFVDIYNV 289
Cdd:COG2319   281 LRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKTLASGSDDGTVRLWDL 359

                         250       260
                  ....*....|....*....|....*...
gi 568979868  290 TSSKRVGVCKGATSYITHIDWDSRGKLL 317
Cdd:COG2319   360 ATGELLRTLTGHTGAVTSVAFSPDGRTL 387
WD40 COG2319
WD40 repeat [General function prediction only];
634-910 1.50e-25

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 110.77  E-value: 1.50e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979868  634 SVHIWDAVNKQTLSILRcSHSKGVCSVSFSATGKLLLSVGLDpeHTVTIWRWQEGAKIASRGGHNQRIFVAEFRPDSDTq 713
Cdd:COG2319   143 TVRLWDLATGKLLRTLT-GHSGAVTSVAFSPDGKLLASGSDD--GTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKL- 218

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979868  714 FVSVGI-KHVKFWTLAGRALLskkGLLSSLEDArmqtMLAVAFGANNLTF-TGTISGDVCVWK-DHILCRVVARAHNGPV 790
Cdd:COG2319   219 LASGSAdGTVRLWDLATGKLL---RTLTGHSGS----VRSVAFSPDGRLLaSGSADGTVRLWDlATGELLRTLTGHSGGV 291

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979868  791 FAMYTTLRDGLIVTGGkerpskEGGAVKLWDQELRRC-RAFRLETGQVTDCVRSvcrGKGKILVGTRNSEIIEVGE-KNA 868
Cdd:COG2319   292 NSVAFSPDGKLLASGS------DDGTVRLWDLATGKLlRTLTGHTGAVRSVAFS---PDGKTLASGSDDGTVRLWDlATG 362

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 568979868  869 ACNILVNGHvDGPIWGLATHPSRDFFLSAAEDGTVRLWDIAD 910
Cdd:COG2319   363 ELLRTLTGH-TGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
624-1102 4.48e-24

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 106.15  E-value: 4.48e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979868  624 DSADMSATAPSVHIWDAVNKQTLSILRCSHSKGVCSVSFSATGKLLLSVGLDpeHTVTIWRWQEGAKIASRGGHNQRIFV 703
Cdd:COG2319     6 GAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGD--LTLLLLDAAAGALLATLLGHTAAVLS 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979868  704 AEFRPDSDTQFVSVGIKHVKFWTLAGRALLskkGLLSSLEDArmqtMLAVAFGANNLTF-TGTISGDVCVWK-DHILCRV 781
Cdd:COG2319    84 VAFSPDGRLLASASADGTVRLWDLATGLLL---RTLTGHTGA----VRSVAFSPDGKTLaSGSADGTVRLWDlATGKLLR 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979868  782 VARAHNGPVFAMyTTLRDG-LIVTGGkerpskEGGAVKLWDqelrrcrafrLETGQvtdCVRSVcrgkgkilvgtrnsei 860
Cdd:COG2319   157 TLTGHSGAVTSV-AFSPDGkLLASGS------DDGTVRLWD----------LATGK---LLRTL---------------- 200

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979868  861 ievgeknaacnilvNGHvDGPIWGLATHPSRDFFLSAAEDGTVRLWDIADKKMLNKVNlGHAA--RTVCYSPEGDMVAIG 938
Cdd:COG2319   201 --------------TGH-TGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLT-GHSGsvRSVAFSPDGRLLASG 264

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979868  939 MKNGEFIILLVSSLKIWGKKRDRRCAIHDIRFSPDSRYLAVGSSENSVDFYDLTLGPTLNRIsycKDIPSFVIQMDFSAD 1018
Cdd:COG2319   265 SADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTL---TGHTGAVRSVAFSPD 341

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979868 1019 SRHLQVSSGCYKRHVYEVPSGKHLvdhaaidritwatwtsilgdevmGIWSRHAekADVTCACVSHSGISLVTGDDFGMV 1098
Cdd:COG2319   342 GKTLASGSDDGTVRLWDLATGELL-----------------------RTLTGHT--GAVTSVAFSPDGRTLASGSADGTV 396


                  ....
gi 568979868 1099 KLYD 1102
Cdd:COG2319   397 RLWD 400
WD40 COG2319
WD40 repeat [General function prediction only];
72-443 1.88e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 104.22  E-value: 1.88e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979868   72 LVKTVKAHDGPVFSMHALEKG--FVTGGKDGMVALWDDSFERCLKTyaikradlapgskglLLEDNPSIRAISLGH-GHI 148
Cdd:COG2319    70 LLATLLGHTAAVLSVAFSPDGrlLASASADGTVRLWDLATGLLLRT---------------LTGHTGAVRSVAFSPdGKT 134

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979868  149 LV-GTKNGEILEVD-KSGPITLLVQGHmEGEVWGLATHP---YLpicATVSDDKTLRIWDLSPSHCMLAVRKLKKGGRCC 223
Cdd:COG2319   135 LAsGSADGTVRLWDlATGKLLRTLTGH-SGAVTSVAFSPdgkLL---ASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV 210

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979868  224 CFSPDGKALAVGLNDGSFLMANADTLEDLVSFHHRKDIISDIRFSPgSGKYLAVASHDSFVDIYNVTSSKRVGVCKGATS 303
Cdd:COG2319   211 AFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSP-DGRLLASGSADGTVRLWDLATGELLRTLTGHSG 289

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979868  304 YITHIDWDSRGKLLqvntgakeqlffeAPRGKRQTIpsveveKI-SWATWTSVLGLccegiwpvIGEVTEVTASCLTSDK 382
Cdd:COG2319   290 GVNSVAFSPDGKLL-------------ASGSDDGTV------RLwDLATGKLLRTL--------TGHTGAVRSVAFSPDG 342

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568979868  383 MVLATGDDLGFVKLFRypaKGKFGKFKKYVAHSTHVTNVRWTYDDSMLVTlGGADMSLMVW 443
Cdd:COG2319   343 KTLASGSDDGTVRLWD---LATGELLRTLTGHTGAVTSVAFSPDGRTLAS-GSADGTVRLW 399
WD40 COG2319
WD40 repeat [General function prediction only];
120-443 5.73e-21

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 96.90  E-value: 5.73e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979868  120 RADLAPGSKGLLLEDNPSIRAISLGHGHILVGTKNGEILEVDKSGPITLLVQGHmEGEVWGLATHPYLPICATVSDDKTL 199
Cdd:COG2319    24 ALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGH-TAAVLSVAFSPDGRLLASASADGTV 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979868  200 RIWDLSPSHCMLAVRKLKKGGRCCCFSPDGKALAVGLNDGSFLMANADTLEDLVSFHHRKDIISDIRFSPgSGKYLAVAS 279
Cdd:COG2319   103 RLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSP-DGKLLASGS 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979868  280 HDSFVDIYNVTSSKRVGVCKGATSYITHIDWDSRGKLL------------QVNTGAKEQLFfeapRGKRQTIPSVEV--- 344
Cdd:COG2319   182 DDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLasgsadgtvrlwDLATGKLLRTL----TGHSGSVRSVAFspd 257

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979868  345 -EKISWATWTSVLGLC----CEGIWPVIGEVTEVTASCLTSDKMVLATGDDLGFVKLFRypaKGKFGKFKKYVAHSTHVT 419
Cdd:COG2319   258 gRLLASGSADGTVRLWdlatGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWD---LATGKLLRTLTGHTGAVR 334

                         330       340
                  ....*....|....*....|....
gi 568979868  420 NVRWTYDDSMLVTlGGADMSLMVW 443
Cdd:COG2319   335 SVAFSPDGKTLAS-GSDDGTVRLW 357
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 72-317 7.85e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 94.32  E-value: 7.85e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979868   72 LVKTVKAHDGPVFSMHALEKG--FVTGGKDGMVALWD---DSFERCLKTYAIKRADLAPGSKGLLLednpsiraislghg 146
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGklLATGSGDGTIKVWDletGELLRTLKGHTGPVRDVAASADGTYL-------------- 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979868  147 hiLVGTKNGEILEVD-KSGPITLLVQGHmEGEVWGLATHPYLPICATVSDDKTLRIWDLSPSHCMLAVRKLKKGGRCCCF 225
Cdd:cd00200    67 --ASGSSDKTIRLWDlETGECVRTLTGH-TSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAF 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979868  226 SPDGKALAVGLNDGSFLMANADTLEDLVSFHHRKDIISDIRFSPgSGKYLAVASHDSFVDIYNVTSSKRVGVCKGATSYI 305
Cdd:cd00200   144 SPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSP-DGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGV 222

                         250
                  ....*....|..
gi 568979868  306 THIDWDSRGKLL 317
Cdd:cd00200   223 NSVAFSPDGYLL 234
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 595-955 1.46e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 93.55  E-value: 1.46e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979868  595 YQEHNDDILCLTVNQHPKFInivATGqvgdSADmsataPSVHIWDAVNKQTLSILrCSHSKGVCSVSFSATGKLLLSVGL 674
Cdd:cd00200     5 LKGHTGGVTCVAFSPDGKLL---ATG----SGD-----GTIKVWDLETGELLRTL-KGHTGPVRDVAASADGTYLASGSS 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979868  675 DpeHTVTIWRWQEGAKIASRGGHNQRIFVAEFRPDSDTqfvsvgikhvkfwtlagrallskkgLLSSLEDarmqtmlava 754
Cdd:cd00200    72 D--KTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRI-------------------------LSSSSRD---------- 114

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979868  755 fgannltftgtisGDVCVWK-DHILCRVVARAHNGPVFAMyTTLRDGLIVTGgkerpSKEGGAVKLWD-QELRRCRAFRL 832
Cdd:cd00200   115 -------------KTIKVWDvETGKCLTTLRGHTDWVNSV-AFSPDGTFVAS-----SSQDGTIKLWDlRTGKCVATLTG 175

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979868  833 ETGQVTDCvrSVCRGKGKILVGTRNSEIIEVGEKNAACNILVNGHvDGPIWGLATHPSRDFFLSAAEDGTVRLWDIADKK 912
Cdd:cd00200   176 HTGEVNSV--AFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGH-ENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGE 252

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*
gi 568979868  913 MLNKVNlGHAAR--TVCYSPEGDMVAIGMKNGefiillvsSLKIW 955
Cdd:cd00200   253 CVQTLS-GHTNSvtSLAWSPDGKRLASGSADG--------TIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
57-291 6.78e-20

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 93.44  E-value: 6.78e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979868   57 SGTSTGDVCIWrDVF---LVKTVKAHDGPVFSMHALEKG--FVTGGKDGMVALWDDSFERCLKTYAikradlapgskgll 131
Cdd:COG2319   179 SGSDDGTVRLW-DLAtgkLLRTLTGHTGAVRSVAFSPDGklLASGSADGTVRLWDLATGKLLRTLT-------------- 243

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979868  132 lEDNPSIRAISLGH-GHILV-GTKNGEILEVD-KSGPITLLVQGHmEGEVWGLATHP---YLpicATVSDDKTLRIWDLS 205
Cdd:COG2319   244 -GHSGSVRSVAFSPdGRLLAsGSADGTVRLWDlATGELLRTLTGH-SGGVNSVAFSPdgkLL---ASGSDDGTVRLWDLA 318

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979868  206 PSHCMLAVRKLKKGGRCCCFSPDGKALAVGLNDGSFLMANADTLEDLVSFHHRKDIISDIRFSPgSGKYLAVASHDSFVD 285
Cdd:COG2319   319 TGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSP-DGRTLASGSADGTVR 397


                  ....*.
gi 568979868  286 IYNVTS 291
Cdd:COG2319   398 LWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 874-1147 6.51e-18

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 85.46  E-value: 6.51e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979868  874 VNGHvDGPIWGLATHPSRDFFLSAAEDGTVRLWDIADKKMLnKVNLGHAA--RTVCYSPEGDMVAIGMKNGefiillvsS 951
Cdd:cd00200     5 LKGH-TGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELL-RTLKGHTGpvRDVAASADGTYLASGSSDK--------T 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979868  952 LKIWgKKRDRRC---------AIHDIRFSPDSRYLAVGSSENSVDFYDLTLGPTLNRISYCKDipsFVIQMDFSADSRHl 1022
Cdd:cd00200    75 IRLW-DLETGECvrtltghtsYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTD---WVNSVAFSPDGTF- 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979868 1023 qVSSGCYKR--HVYEVPSGKHlvdhaaidritwatwtsilgdevmgIWSRHAEKADVTCACVSHSGISLVTGDDFGMVKL 1100
Cdd:cd00200   150 -VASSSQDGtiKLWDLRTGKC-------------------------VATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKL 203

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 568979868 1101 YDfpcPEKFAKHKRFLGHSPHVTNIRFtSGDRHVVSAGGDDCSLFVW 1147
Cdd:cd00200   204 WD---LSTGKCLGTLRGHENGVNSVAF-SPDGYLLASGSEDGTIRVW 246
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 45-288 1.52e-15

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 78.53  E-value: 1.52e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979868   45 CAVYGWTEEMAfSGTSTGDVCIW--RDVFLVKTVKAHDGPVFSMHALEKG--FVTGGKDGMVALWDDSFERCLKTYAIKR 120
Cdd:cd00200    57 VAASADGTYLA-SGSSDKTIRLWdlETGECVRTLTGHTSYVSSVAFSPDGriLSSSSRDKTIKVWDVETGKCLTTLRGHT 135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979868  121 ADlapgskglllednpsIRAISLGHGHILV--GTKNGEIL--EVDKSGPITLLvQGHmEGEVWGLATHPYLPICATVSDD 196
Cdd:cd00200   136 DW---------------VNSVAFSPDGTFVasSSQDGTIKlwDLRTGKCVATL-TGH-TGEVNSVAFSPDGEKLLSSSSD 198

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979868  197 KTLRIWDLSPSHCMLAVRKLKKGGRCCCFSPDGKALAVGLNDGSFLMANADTLEDLVSFHHRKDIISDIRFSPgSGKYLA 276
Cdd:cd00200   199 GTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSP-DGKRLA 277

                         250
                  ....*....|..
gi 568979868  277 VASHDSFVDIYN 288
Cdd:cd00200   278 SGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 841-1148 3.44e-15

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 77.38  E-value: 3.44e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979868  841 VRSVC--RGKGKILVGTRNSEIIEVGEKNAACNILVNGHvDGPIWGLATHPSRDFFLSAAEDGTVRLWDIADKKMLNKVN 918
Cdd:cd00200    12 VTCVAfsPDGKLLATGSGDGTIKVWDLETGELLRTLKGH-TGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLT 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979868  919 lGHAA--RTVCYSPEGDMVAIGMKNGefiillvsSLKIW----GKK----RDRRCAIHDIRFSPDSRYLAVGSSENSVDF 988
Cdd:cd00200    91 -GHTSyvSSVAFSPDGRILSSSSRDK--------TIKVWdvetGKClttlRGHTDWVNSVAFSPDGTFVASSSQDGTIKL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979868  989 YDLTLGPTLNRIsycKDIPSFVIQMDFSADSRHLQVSSGCYKRHVYEVPSGKHLVDHaaidritwatwtsilgdevmgiw 1068
Cdd:cd00200   162 WDLRTGKCVATL---TGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTL----------------------- 215

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979868 1069 srHAEKADVTCACVSHSGISLVTGDDFGMVKLYDFpcpEKFAKHKRFLGHSPHVTNIRFtSGDRHVVSAGGDDCSLFVWK 1148
Cdd:cd00200   216 --RGHENGVNSVAFSPDGYLLASGSEDGTIRVWDL---RTGECVQTLSGHTNSVTSLAW-SPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
161-729 8.47e-15

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 78.03  E-value: 8.47e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979868  161 DKSGPITLLVQGHMEGEVWGLATHPYLPICATVSDDKTLRIWDLSPSHCMLAVRKLKKGGRCCCFSPDGKALAVGLNDGS 240
Cdd:COG2319    22 AAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGT 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979868  241 FLMANADTLEDLVSFHHRKDIISDIRFSPgSGKYLAVASHDSFVDIYNVTSSKRVGVCKGATSYITHIDWDSRGKLLqvn 320
Cdd:COG2319   102 VRLWDLATGLLLRTLTGHTGAVRSVAFSP-DGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLL--- 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979868  321 tgakeqlffeAPRGKRQTIpsveveKIswatWTSVLGLCcegIWPVIGEVTEVTASCLTSDKMVLATGDDLGFVKLFRyp 400
Cdd:COG2319   178 ----------ASGSDDGTV------RL----WDLATGKL---LRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWD-- 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979868  401 aKGKFGKFKKYVAHSTHVTNVRWTYDDSMLVTlGGADMSLMVWtneveshrekkycdseesDIDSeedggydsdvtrene 480
Cdd:COG2319   233 -LATGKLLRTLTGHSGSVRSVAFSPDGRLLAS-GSADGTVRLW------------------DLAT--------------- 277

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979868  481 isytiralstnirpmfgvkphlqqkepsvDERQGVVRGSRPPVsrappqpeklqsnnvgkkkrpiedlvlelafgyrgrd 560
Cdd:COG2319   278 -----------------------------GELLRTLTGHSGGV------------------------------------- 291

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979868  561 crNNVHYLNDGddiiyhtasigilhnvatgtqsfyqehnddilcltvnqhpkfiNIVATGqvgdSADmsataPSVHIWDA 640
Cdd:COG2319   292 --NSVAFSPDG-------------------------------------------KLLASG----SDD-----GTVRLWDL 317

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979868  641 VNKQTLSILRcSHSKGVCSVSFSATGKLLLSVGLDpeHTVTIWRWQEGAKIASRGGHNQRIFVAEFRPDSDTqFVSVGI- 719
Cdd:COG2319   318 ATGKLLRTLT-GHTGAVRSVAFSPDGKTLASGSDD--GTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRT-LASGSAd 393

                         570
                  ....*....|
gi 568979868  720 KHVKFWTLAG 729
Cdd:COG2319   394 GTVRLWDLAT 403
HELP pfam03451
HELP motif; The founding member of the EMAP protein family is the 75 kDa Echinoderm ...
 540-587 8.44e-14

HELP motif; The founding member of the EMAP protein family is the 75 kDa Echinoderm Microtubule-Associated Protein, so-named for its abundance in sea urchin, sand dollar and starfish eggs. The Hydrophobic EMAP-Like Protein (HELP) motif was identified initially in the human EMAP-Like Protein 2 (EML2) and subsequently in the entire EMAP Protein family. The HELP motif is approximately 60-70 amino acids in length and is conserved amongst metazoans. Although the HELP motif is hydrophobic, there is no evidence that EMAP-Like Proteins are membrane-associated. All members of the EMAP-Like Protein family, identified to-date, are constructed with an amino terminal HELP motif followed by a WD domain. In C. elegans, EMAP-Like Protein-1 (ELP-1) is required for touch sensation indicating that ELP-1 may play a role in mechanosensation. The localization of ELP-1 to microtubules and adhesion sites implies that ELP-1 may transmit forces between the body surface and the touch receptor neurons.


Pssm-ID: 460922  Cd Length: 72  Bit Score: 67.19  E-value: 8.44e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 568979868   540 KKKRPIEDLVLELAFGYRGRDCRNNVHYLNDGdDIIYHTASIGILHNV 587
Cdd:pfam03451   26 KKEPPDKKLKLEWVYGYRGKDCRSNLYYLPTG-EIVYFTAAVVVLYDV 72
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 38-240 4.64e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 65.05  E-value: 4.64e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979868   38 GKNDTMMCAVYGWTEEMAFSGTSTGDVCIW--RDVFLVKTVKAHDGPVFSMHALE-KGFVTGGK-DGMVALWDDSFERCL 113
Cdd:cd00200    91 GHTSYVSSVAFSPDGRILSSSSRDKTIKVWdvETGKCLTTLRGHTDWVNSVAFSPdGTFVASSSqDGTIKLWDLRTGKCV 170

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979868  114 KTYaikradlaPGSKGlllednpSIRAISLGH--GHILVGTKNGEILEVDKSGPITL-LVQGHmEGEVWGLATHPYLPIC 190
Cdd:cd00200   171 ATL--------TGHTG-------EVNSVAFSPdgEKLLSSSSDGTIKLWDLSTGKCLgTLRGH-ENGVNSVAFSPDGYLL 234

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 568979868  191 ATVSDDKTLRIWDLSPSHCMLAVRKLKKGGRCCCFSPDGKALAVGLNDGS 240
Cdd:cd00200   235 ASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGT 284
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 38-203 4.45e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 58.89  E-value: 4.45e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979868   38 GKNDTMMCAVYGWTEEMAFSGTSTGDVCIW--RDVFLVKTVKAHDGPVFSMHALEKG--FVTGGKDGMVALWDDSFERCL 113
Cdd:cd00200   133 GHTDWVNSVAFSPDGTFVASSSQDGTIKLWdlRTGKCVATLTGHTGEVNSVAFSPDGekLLSSSSDGTIKLWDLSTGKCL 212

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979868  114 KTYAIKRA---DLAPGSKGLLL----EDNpSIRAISLghghilvgtKNGEILEVdksgpitllVQGHmEGEVWGLATHPY 186
Cdd:cd00200   213 GTLRGHENgvnSVAFSPDGYLLasgsEDG-TIRVWDL---------RTGECVQT---------LSGH-TNSVTSLAWSPD 272

                         170
                  ....*....|....*..
gi 568979868  187 LPICATVSDDKTLRIWD 203
Cdd:cd00200   273 GKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
886-1147 5.58e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 59.54  E-value: 5.58e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979868  886 ATHPSRDFFLSAAEDGTVRLWDIADKKMLNKVNLGHAARTVC-YSPEGDMVAIGMKNGEFIILLVSSLKIWGKKRDRRCA 964
Cdd:COG2319     1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLaASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979868  965 IHDIRFSPDSRYLAVGSSENSVDFYDLTLGPTLNRIsycKDIPSFVIQMDFSADSRHLqVSSGCYKR-HVYEVPSGKH-- 1041
Cdd:COG2319    81 VLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTL---TGHTGAVRSVAFSPDGKTL-ASGSADGTvRLWDLATGKLlr 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979868 1042 -LVDHA-AIDRITWA----TWTSILGDEVMGIWSRHAEK---------ADVTCACVSHSGISLVTGDDFGMVKLYDfpcP 1106
Cdd:COG2319   157 tLTGHSgAVTSVAFSpdgkLLASGSDDGTVRLWDLATGKllrtltghtGAVRSVAFSPDGKLLASGSADGTVRLWD---L 233

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 568979868 1107 EKFAKHKRFLGHSPHVTNIRFTSGDRHVVSAGGDDcSLFVW 1147
Cdd:COG2319   234 ATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADG-TVRLW 273
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 926-1008 9.56e-06

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 44.96  E-value: 9.56e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979868   926 VCYSPEGDMVAIGMKNGEFIILLVSSLKIWGKKRDRR-CAIHDIRFSPDSRYLAVGSSENSVDFYDLTLGPTLNRISYCK 1004
Cdd:pfam12894    1 MSWCPTMDLIALATEDGELLLHRLNWQRVWTLSPDKEdLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGS 80


                   ....
gi 568979868  1005 DIPS 1008
Cdd:pfam12894   81 DLIT 84
WD40 pfam00400
WD domain, G-beta repeat;
875-907 2.73e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.25  E-value: 2.73e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 568979868   875 NGHvDGPIWGLATHPSRDFFLSAAEDGTVRLWD 907
Cdd:pfam00400    8 EGH-TGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 875-907 3.38e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.22  E-value: 3.38e-04
                            10        20        30
                    ....*....|....*....|....*....|...
gi 568979868    875 NGHvDGPIWGLATHPSRDFFLSAAEDGTVRLWD 907
Cdd:smart00320    9 KGH-TGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 171-203 2.54e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.52  E-value: 2.54e-03
                            10        20        30
                    ....*....|....*....|....*....|...
gi 568979868    171 QGHmEGEVWGLATHPYLPICATVSDDKTLRIWD 203
Cdd:smart00320    9 KGH-TGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
894-1027 8.06e-03

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 39.29  E-value: 8.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979868  894 FLSAAEDGTVRLWDIADKKMLNKVNLGHAARTVCYSPEGDMVAI-GMKNGEFIILLVSSLKIWGKkrdrrcaI------H 966
Cdd:COG3391    83 YVANSGSGRVSVIDLATGKVVATIPVGGGPRGLAVDPDGGRLYVaDSGNGRVSVIDTATGKVVAT-------IpvgagpH 155

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568979868  967 DIRFSPDSRYLAVGSSENS-----VDFYDLTLGPTLNRIsyckDIPSFVIQMDFSADSRHLQVSSG 1027
Cdd:COG3391   156 GIAVDPDGKRLYVANSGSNtvsviVSVIDTATGKVVATI----PVGGGPVGVAVSPDGRRLYVANR 217
WD40 pfam00400
WD domain, G-beta repeat;
171-203 9.65e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.01  E-value: 9.65e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 568979868   171 QGHmEGEVWGLATHPYLPICATVSDDKTLRIWD 203
Cdd:pfam00400    8 EGH-TGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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