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Conserved domains on  [gi|568981785|ref|XP_006516716|]
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sodium-dependent phosphate transport protein 3 isoform X7 [Mus musculus]

Protein Classification

MFS transporter( domain architecture ID 999995)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 21-312 1.02e-81

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17318:

Pssm-ID: 475125 [Multi-domain]  Cd Length: 389  Bit Score: 253.70  E-value: 1.02e-81
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981785  21 ALIMHFSNFTMITQRVSLSIAIIAMVNSTQHQDPANASTegpvmdllsnqsrGIKDFSTRAAVYQWSTETQGIIFSSISY 100
Cdd:cd17318    1 AILLFLGFAVVYAMRVNLSVAIVAMVNSTATHDNNNTST-------------DKDTLPVEAPEFDWSEKTQGIILSSFFY 67

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981785 101 GIILTLIPSGYLAGIFGAKQILGAGLLISSLLTLFTPLAADFGVILVIVIRTVQGMAQGMAWTGQFTIWAKWAPPLERSK 180
Cdd:cd17318   68 GYILTQIPGGYLAEKYGAKRVLGYSILITALLTLLTPLAARGGYGALIVLRILQGLAQGVTFPAMHALWAKWAPPLERSR 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981785 181 LTSIAGSGEDVGSVWVLhhPLCGRI-NLTGTGLAFYLLHlCIGCVCCVLWFTViyddpmhhpcisvrekehitssvaqqs 259
Cdd:cd17318  148 LTSIAYSGSQFGTVIAM--PLSGFLcESLGWPSIFYIFG-GLGLLWCLLWFFL--------------------------- 197

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 568981785 260 ssprrsvpikamvrCLPLWAIFMGFFSHFWLCTIIITYLPTYISTVLHVNIRD 312
Cdd:cd17318  198 --------------VLPVWAIVVAHFGHNWGFYTLLTELPTYMSDVLHFNIKS 236
 
Name Accession Description Interval E-value
MFS_SLC17 cd17318
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ...
 21-312 1.02e-81

Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340876 [Multi-domain]  Cd Length: 389  Bit Score: 253.70  E-value: 1.02e-81
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981785  21 ALIMHFSNFTMITQRVSLSIAIIAMVNSTQHQDPANASTegpvmdllsnqsrGIKDFSTRAAVYQWSTETQGIIFSSISY 100
Cdd:cd17318    1 AILLFLGFAVVYAMRVNLSVAIVAMVNSTATHDNNNTST-------------DKDTLPVEAPEFDWSEKTQGIILSSFFY 67

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981785 101 GIILTLIPSGYLAGIFGAKQILGAGLLISSLLTLFTPLAADFGVILVIVIRTVQGMAQGMAWTGQFTIWAKWAPPLERSK 180
Cdd:cd17318   68 GYILTQIPGGYLAEKYGAKRVLGYSILITALLTLLTPLAARGGYGALIVLRILQGLAQGVTFPAMHALWAKWAPPLERSR 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981785 181 LTSIAGSGEDVGSVWVLhhPLCGRI-NLTGTGLAFYLLHlCIGCVCCVLWFTViyddpmhhpcisvrekehitssvaqqs 259
Cdd:cd17318  148 LTSIAYSGSQFGTVIAM--PLSGFLcESLGWPSIFYIFG-GLGLLWCLLWFFL--------------------------- 197

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 568981785 260 ssprrsvpikamvrCLPLWAIFMGFFSHFWLCTIIITYLPTYISTVLHVNIRD 312
Cdd:cd17318  198 --------------VLPVWAIVVAHFGHNWGFYTLLTELPTYMSDVLHFNIKS 236
2A0114euk TIGR00894
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
 1-311 1.76e-79

Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]


Pssm-ID: 129972 [Multi-domain]  Cd Length: 465  Bit Score: 250.43  E-value: 1.76e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981785    1 MDEKPTTRKGSGFCSLRYALALIMHFSNFTMITQRVSLSIAIIAMVNSTQHQDPANASTEGPVmdllsnqsrgikdFSTR 80
Cdd:TIGR00894   1 MENVFASTKLPYFCSFRLFLSFLLHICNVIIIAQRICLSLTMVAMVNKENSTDLACLSAENEL-------------DNIK 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981785   81 AAVYQWSTETQGIIFSSISYGIILTLIPSGYLAGIFGAKQILGAGLLISSLLTLFTPLAADFGVILVIVIRTVQGMAQGM 160
Cdd:TIGR00894  68 NPNFKWSGALQGLILSSHFYGQIIIQIPVGYLAGKYVFKWSIGIGMFLSSVISIVIPWAAGGGIALVVFCRVIQGLAQGS 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981785  161 AWTGQFTIWAKWAPPLERSKLTSIAGSGEDVGSVWVLhhPLCGRINLTGTG--LAFYLLHLCiGCVCCVLWFTVIYDDPM 238
Cdd:TIGR00894 148 VSPATHKIIVKWAPPKERSRLLGMSTSGFQLGTFIFL--PISGWLCESWGGwpMIFYVFGIV-GCAWSLLWFVFPADDPS 224

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568981785  239 HHPCISVREKEHITSSVAQQSSSPRRSVPIKAMVRCLPLWAIFMGFFSHFWLCTIIITYLPTYISTVLHVNIR 311
Cdd:TIGR00894 225 IHPCISKFEKKYINSSLQGQKGSTRQSLPIKAIPKSLPVWAIWFAIFGHFWLYTILPTYLPTFISWVLRVSGK 297
MFS_1 pfam07690
Major Facilitator Superfamily;
84-304 1.28e-13

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 70.91  E-value: 1.28e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981785   84 YQWSTETQGIIFSSISYGIILTLIPSGYLAGIFGAKQILGAGLLISSLLTLFTPLAAdfGVILVIVIRTVQGMAQGMAWT 163
Cdd:pfam07690  27 LGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFAS--SLWLLLVLRVLQGLGAGALFP 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981785  164 GQFTIWAKWAPPLERSKLTSIAGSGEDVGSvwVLHHPLCGRINLTGTGLAFYLLHLCIGCVCCVLWFtviyddpmhhpci 243
Cdd:pfam07690 105 AALALIADWFPPEERGRALGLVSAGFGLGA--ALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLL------------- 169

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568981785  244 sVREKEHITSSVAQQSSSPRRSVPIKAMVRCLPLWAIFMGFFSHFWLCTIIITYLPTYIST 304
Cdd:pfam07690 170 -LPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEV 229
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
84-234 1.68e-13

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 70.67  E-value: 1.68e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981785  84 YQWSTETQGIIFSSISYGIILTLIPSGYLAGIFGAKQILGAGLLISSLLTLFTPLAADFGVIlvIVIRTVQGMAQGMAWT 163
Cdd:COG2271   40 LGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSFWQL--LLLRFLLGLGEAGFFP 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981785 164 GQFTIWAKWAPPLERSKLTSIAGSGEDVGSV-------WVLHHP-------LCGRINLTGTGLAFYLLHLCIGCVCCVLW 229
Cdd:COG2271  118 AALKLIAEWFPPKERGRALGIFNAGGPLGGAlappllgWLLAAFgwraaflILGLPGLLLALLRFWLLALAYFLVYFALY 197


                 ....*
gi 568981785 230 FTVIY 234
Cdd:COG2271  198 GFLTW 202
 
Name Accession Description Interval E-value
MFS_SLC17 cd17318
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ...
 21-312 1.02e-81

Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340876 [Multi-domain]  Cd Length: 389  Bit Score: 253.70  E-value: 1.02e-81
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981785  21 ALIMHFSNFTMITQRVSLSIAIIAMVNSTQHQDPANASTegpvmdllsnqsrGIKDFSTRAAVYQWSTETQGIIFSSISY 100
Cdd:cd17318    1 AILLFLGFAVVYAMRVNLSVAIVAMVNSTATHDNNNTST-------------DKDTLPVEAPEFDWSEKTQGIILSSFFY 67

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981785 101 GIILTLIPSGYLAGIFGAKQILGAGLLISSLLTLFTPLAADFGVILVIVIRTVQGMAQGMAWTGQFTIWAKWAPPLERSK 180
Cdd:cd17318   68 GYILTQIPGGYLAEKYGAKRVLGYSILITALLTLLTPLAARGGYGALIVLRILQGLAQGVTFPAMHALWAKWAPPLERSR 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981785 181 LTSIAGSGEDVGSVWVLhhPLCGRI-NLTGTGLAFYLLHlCIGCVCCVLWFTViyddpmhhpcisvrekehitssvaqqs 259
Cdd:cd17318  148 LTSIAYSGSQFGTVIAM--PLSGFLcESLGWPSIFYIFG-GLGLLWCLLWFFL--------------------------- 197

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 568981785 260 ssprrsvpikamvrCLPLWAIFMGFFSHFWLCTIIITYLPTYISTVLHVNIRD 312
Cdd:cd17318  198 --------------VLPVWAIVVAHFGHNWGFYTLLTELPTYMSDVLHFNIKS 236
2A0114euk TIGR00894
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
 1-311 1.76e-79

Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]


Pssm-ID: 129972 [Multi-domain]  Cd Length: 465  Bit Score: 250.43  E-value: 1.76e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981785    1 MDEKPTTRKGSGFCSLRYALALIMHFSNFTMITQRVSLSIAIIAMVNSTQHQDPANASTEGPVmdllsnqsrgikdFSTR 80
Cdd:TIGR00894   1 MENVFASTKLPYFCSFRLFLSFLLHICNVIIIAQRICLSLTMVAMVNKENSTDLACLSAENEL-------------DNIK 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981785   81 AAVYQWSTETQGIIFSSISYGIILTLIPSGYLAGIFGAKQILGAGLLISSLLTLFTPLAADFGVILVIVIRTVQGMAQGM 160
Cdd:TIGR00894  68 NPNFKWSGALQGLILSSHFYGQIIIQIPVGYLAGKYVFKWSIGIGMFLSSVISIVIPWAAGGGIALVVFCRVIQGLAQGS 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981785  161 AWTGQFTIWAKWAPPLERSKLTSIAGSGEDVGSVWVLhhPLCGRINLTGTG--LAFYLLHLCiGCVCCVLWFTVIYDDPM 238
Cdd:TIGR00894 148 VSPATHKIIVKWAPPKERSRLLGMSTSGFQLGTFIFL--PISGWLCESWGGwpMIFYVFGIV-GCAWSLLWFVFPADDPS 224

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568981785  239 HHPCISVREKEHITSSVAQQSSSPRRSVPIKAMVRCLPLWAIFMGFFSHFWLCTIIITYLPTYISTVLHVNIR 311
Cdd:TIGR00894 225 IHPCISKFEKKYINSSLQGQKGSTRQSLPIKAIPKSLPVWAIWFAIFGHFWLYTILPTYLPTFISWVLRVSGK 297
MFS_SLC17A5 cd17381
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of ...
 20-312 1.42e-49

Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of transporters; Solute carrier family 17 member 5 (SLC17A5) is also called sialin, H(+)/nitrate cotransporter, H(+)/sialic acid cotransporter (AST), membrane glycoprotein HP59, or vesicular H(+)/aspartate-glutamate cotransporter. It transports glucuronic acid and free sialic acid out of the lysosome after its cleavage from sialoglycoconjugates, which is required for normal CNS myelination. It also mediates the membrane potential-dependent uptake of aspartate and glutamate into synaptic vesicles and synaptic-like microvesicles. In the plasma membrane, it functions as a nitrate transporter. Recessive mutations in the SLC17A5 gene cause the allelic disorders, Infantile sialic acid storage disease (ISSD) and Salla disease (a predominantly neurological disorder). SLC17A5 belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340939 [Multi-domain]  Cd Length: 397  Bit Score: 170.73  E-value: 1.42e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981785  20 LALIMHFSNFTMITQRVSLSIAIIAMVNSTQHQDPANASTEGPVmdllSNQSRGIKDFSTrAAVYQWSTETQGIIFSSIS 99
Cdd:cd17381    1 LALLAFFGFFVVYALRVNLSVALVDMVNSNSTLPSNNSSNACPE----HSSSPSVEHNET-GKKYDWDAETQGWILGSFF 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981785 100 YGIILTLIPSGYLAGIFGAKQILGAGLLISSLLTLFTPLAADFGVILVIVIRTVQGMAQGMAWTGQFTIWAKWAPPLERS 179
Cdd:cd17381   76 YGYIITQIPGGYLASKIGGKLLLGFGILGTAVFTLLTPLAADLGAGYLIAVRALEGLGEGVTFPAMHAMWASWAPPLERS 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981785 180 KLTSIAGSGEDVGSVWVLhhPLCGRINLTGTGLAFYLLHLCIGCVCCVLWFTVIyddpmhhpcisvrekehitssvaqqs 259
Cdd:cd17381  156 RLLTISYAGAQLGTVVSL--PLSGLICYYLDWTYVFYIFGAVGLLWFFLWIWLV-------------------------- 207

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 568981785 260 ssprrsvpikamvrcLPLWAIFMGFFSHFWLCTIIITYLPTYISTVLHVNIRD 312
Cdd:cd17381  208 ---------------MPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFDIQE 245
MFS_SLC17A6_7_8_VGluT cd17382
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of ...
 35-318 6.96e-28

Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 17 member 6 (SLC17A6), SLC17A7, SLC17A8, and similar proteins. SLC17A6 is also called vesicular glutamate transporter 2 (VGluT2), differentiation-associated BNPI, or differentiation-associated Na(+)-dependent inorganic phosphate cotransporter. SLC17A7 is also called VGluT1 or brain-specific Na(+)-dependent inorganic phosphate cotransporter. SLC17A8 is also called VGluT3. They mediate the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells, and may also mediate the transport of inorganic phosphate. VGluTs are also expressed and localized in various secretory vesicles in non-neuronal peripheral organelles such as hormone-containing secretory granules in endocrine cells, and thus, also act as metabolic regulators. The VGluT subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340940 [Multi-domain]  Cd Length: 380  Bit Score: 112.05  E-value: 6.96e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981785  35 RVSLSIAIIAMVNSTQHQDPANASTEGPVMDllsnqsrgikdfstraavyqWSTETQGIIFSSISYGIILTLIPSGYLAG 114
Cdd:cd17382   15 RCNLGVAIVRMVNNFTDAYGGKVIVHKAEFN--------------------WTPETVGLIESSFFWGYLVTQIPGGFIAA 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981785 115 IFGAKQILGAGLLISSLLTLFTPLAADFGVILVIVIRTVQGMAQGMAWTGQFTIWAKWAPPLERSKLTSIAGSGEDVGSV 194
Cdd:cd17382   75 KFAANRVFGLAIFVTSTLNMLIPIAARVHYGCVIFVRILQGLVEGVTYPACHGIWRKWAPPLERSRLATTAFCGSYAGAV 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981785 195 WVLhhPLCG-RINLTGTGLAFYLLHLCiGCVCCVLWFTViyddpmhhpcisvrekehitssvaqqsssprrsvpikamvr 273
Cdd:cd17382  155 VGM--PLSGiLVQYVGWSSPFYVYGVF-GIIWYMFWMLV----------------------------------------- 190

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 568981785 274 CLPLWAIFMGFFSHFWLCTIIITYLPTYISTVLHVNIRD---ICKFPH 318
Cdd:cd17382  191 SMPVYAIIVANFCRSWTFYLLLISQPAYFKEVFGFDISKvgiLSALPH 238
MFS_SLC17A9_like cd17380
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ...
 81-333 7.60e-23

Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340938 [Multi-domain]  Cd Length: 361  Bit Score: 97.63  E-value: 7.60e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981785  81 AAVYQWSTETQGIIFSSISYGIILTLIPSGYLAGIFGAKQILGAGLLISSLLTLFTPLAADFGVILVIVIRTVQGMAQGM 160
Cdd:cd17380   26 AKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLLTPLLAYSSLPLLILSRILLGLGEGV 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981785 161 AWTGQFTIWAKWAPPLERSKLTSIAGSGEDVGSVwvlhhpLCGRI-----NLTGTGLAFYLLHLcIGCVCCVLWFTVIyd 235
Cdd:cd17380  106 HFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTL------LGGLIgplllEYYGWPSVFYFFGL-LGLLWALVWLIYL-- 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981785 236 dpmhhpcisvrekehitssvaqqsssprrsvpikamvrcLPLWAIFMGFFSHFWLCTIIITYLPTYISTVLHVNIRD--- 312
Cdd:cd17380  177 ---------------------------------------PPVWAIIVAHFCMNWGFYILLSWLPTYFHEVLVPLAKGwvf 217

                        250       260
                 ....*....|....*....|....*.
gi 568981785 313 -----ICKFPHGHLKGIWSycrDHLI 333
Cdd:cd17380  218 nvvpwLVMFPSSNVAGWLA---DHLI 240
MFS_1 pfam07690
Major Facilitator Superfamily;
84-304 1.28e-13

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 70.91  E-value: 1.28e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981785   84 YQWSTETQGIIFSSISYGIILTLIPSGYLAGIFGAKQILGAGLLISSLLTLFTPLAAdfGVILVIVIRTVQGMAQGMAWT 163
Cdd:pfam07690  27 LGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFAS--SLWLLLVLRVLQGLGAGALFP 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981785  164 GQFTIWAKWAPPLERSKLTSIAGSGEDVGSvwVLHHPLCGRINLTGTGLAFYLLHLCIGCVCCVLWFtviyddpmhhpci 243
Cdd:pfam07690 105 AALALIADWFPPEERGRALGLVSAGFGLGA--ALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLL------------- 169

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568981785  244 sVREKEHITSSVAQQSSSPRRSVPIKAMVRCLPLWAIFMGFFSHFWLCTIIITYLPTYIST 304
Cdd:pfam07690 170 -LPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEV 229
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
84-234 1.68e-13

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 70.67  E-value: 1.68e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981785  84 YQWSTETQGIIFSSISYGIILTLIPSGYLAGIFGAKQILGAGLLISSLLTLFTPLAADFGVIlvIVIRTVQGMAQGMAWT 163
Cdd:COG2271   40 LGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSFWQL--LLLRFLLGLGEAGFFP 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981785 164 GQFTIWAKWAPPLERSKLTSIAGSGEDVGSV-------WVLHHP-------LCGRINLTGTGLAFYLLHLCIGCVCCVLW 229
Cdd:COG2271  118 AALKLIAEWFPPKERGRALGIFNAGGPLGGAlappllgWLLAAFgwraaflILGLPGLLLALLRFWLLALAYFLVYFALY 197


                 ....*
gi 568981785 230 FTVIY 234
Cdd:COG2271  198 GFLTW 202
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 81-307 9.76e-13

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 68.61  E-value: 9.76e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981785  81 AAVYQWSTETQGIIFSSISYGIILTLIPSGYLAGIFGAKQILGAGLLISSLLTLFTPLAADFGVILviVIRTVQGMAQGM 160
Cdd:cd06174   23 LQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLL--LGRFLLGLGSGL 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981785 161 AWTGQFTIWAKWAPPLERSKLTSIAGSGedvGSVWVLHHPLCGRINLTGTGLAFYLLHLcIGCVCCVLWFTVIYddpmhh 240
Cdd:cd06174  101 IDPAVLALIADLFPERERGRALGLLQAF---GSVGGILGPLLGGILASSLGFGWRAVFL-IAAALALLAAILLL------ 170

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568981785 241 pcISVREKEHITSSVAQQSSSPRRSVPIKAMVRCLPLWAIFMGFFSHFWLCTIIITYLPTYISTVLH 307
Cdd:cd06174  171 --LVVPDPPESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGG 235
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
81-313 1.89e-11

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 64.22  E-value: 1.89e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981785  81 AAVYQWSTETQGIIFSSISYGIILTLIPSGYLAGIFGAKQILGAGLLISSLLTLFTPLAADFGVIlvIVIRTVQGMAQGM 160
Cdd:COG2814   37 AADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLL--LAARFLQGLGAGA 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981785 161 AWTGQFTIWAKWAPPLERSKLTSIAGSGEDVGSV-------WVLHHplcgrinlTGTGLAFYLLHLCIGCVCCVLWFTVi 233
Cdd:COG2814  115 LFPAALALIADLVPPERRGRALGLLGAGLGLGPAlgpllggLLADL--------FGWRWVFLVNAVLALLALLLLLRLL- 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981785 234 yddpmhhpcisvrekehitsSVAQQSSSPRRSVPIKAMVRCLPLWAIFMGFFSHFWLCTIIITYLPTYISTVLHVNIRDI 313
Cdd:COG2814  186 --------------------PESRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAA 245
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 92-313 2.37e-11

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 64.13  E-value: 2.37e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981785  92 GIIFSSISYGIILTLIPSGYLAGIFGAKQILGAGLLISSLLTLFTPLAADFGVIlvIVIRTVQGMAQGMAWTGQFTIWAK 171
Cdd:cd17325   34 GLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQL--LLARFLQGLASAAVWPAAMALIAD 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981785 172 WAPPLERSKLTSIAGSGEDVGsvWVLHHPLCGRI-NLTGTGLAFYllhLCIGCVCCVLWFTVIYDdpmhhpcisvreKEH 250
Cdd:cd17325  112 IAPPEERGRAMGIFSSAIGLG--FLIGPLLGGLLaDALGYRAPFL---VCAALALLALVLALLLL------------PEP 174

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568981785 251 ITSSVAQQSSSPRRSVPIKAMVRCLPLWAIFMGFFSHFWLCTIIITYLPTYISTVLHVNIRDI 313
Cdd:cd17325  175 RPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQI 237
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 85-310 3.10e-10

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 60.66  E-value: 3.10e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981785  85 QWSTETQGIIFSSISYGIILTLIPSGYLAGIFGAKQILGAGLLISSLLTLFTPLAadFGVILVIVIRTVQGMAQGMAWTG 164
Cdd:cd17319   34 GLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFA--TSLTSLYVLRFLLGVAEAGFFPG 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981785 165 QFTIWAKWAPPLERSKLTSIAGSGEDVGSVWVLhhPLCGRI-NLTGTGLAFYLLHLcIGCVCCVLWFTVIYDdpmhhpci 243
Cdd:cd17319  112 AIKALAEWFPARERGRATGLFNSGAPLGAAIGP--PLSGWLlLLFGWRWAFIIEGL-LGLLLAVLWWFYLRQ-------- 180

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568981785 244 svrekehitssvaqqsssprrsvpikamvrclpLWAIFMGFFSHFWLCTIIITYLPTYISTVLHVNI 310
Cdd:cd17319  181 ---------------------------------VWGLALGYFGINYALYGLLTWLPTYLKQARGFSL 214
2A0104 TIGR00881
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...
 92-308 6.67e-10

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273319 [Multi-domain]  Cd Length: 379  Bit Score: 59.70  E-value: 6.67e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981785   92 GIIFSSISYGIILTLIPSGYLAGIFGAKQILGAGLLISSLLTLFtpLAADFGVILVIVIRTVQGMAQGMAWTGQFTIWAK 171
Cdd:TIGR00881  33 GLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLF--FGFSTSLWVMAALWALNGIFQGMGWPPCGRTVTK 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981785  172 WAPPLERSKLTSIAGSGEDVGSVWVLHHPLCGrINLTGTGLAFYLLHLCIGCVCCVLWFTVIYDDPMHHPCISVREKEHI 251
Cdd:TIGR00881 111 WFSRSERGTWVSFWNCSHNVGGGLLPPLVLFG-IAELYSWHWVFIVPGIIAIIVSLICFLLLRDSPQSCGLPPAEEMPNE 189

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981785  252 TSSVAQQSSSPRRS---VPIKAMVRCLPLWAIFMGFFSHFWLCTIIITYLPTYISTVLHV 308
Cdd:TIGR00881 190 EPDGDAEKKEEELTkkqIFLQYVLLNKVLWYISLGYVFVYVVRTGILDWSPLYLTQEKGF 249
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 81-194 5.92e-09

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 56.36  E-value: 5.92e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981785  81 AAVYQWSTETQGIIFSSISYGIILTLIPSGYLAGIFGAKQILGAGLLISSLLTLFTPLAadFGVILVIVIRTVQGMAQGM 160
Cdd:COG0477   41 AADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLA--PSPELLIAARALQGIGAGG 118

                         90       100       110
                 ....*....|....*....|....*....|....
gi 568981785 161 AWTGQFTIWAKWAPPLERSKLTSIAGSGEDVGSV 194
Cdd:COG0477  119 LMPGALALIAELFPARERGRALGLWGAAIGLGLA 152
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
81-312 6.96e-08

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 53.73  E-value: 6.96e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981785  81 AAVYQWSTETQGIIFSSISYGIILTLIPSGYLAGIFGAKQILGAGLLISSLLTLFTPLAADFGVILviVIRTVQGMAQGM 160
Cdd:COG2223   32 AEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLLL--LLGLLLGIGGGG 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981785 161 AWTGQFTIWAKWAPPLERSKLTSIAGSGEDVGSVWVLhhPLCGR-INLTGTGLAFYLLhLCIGCVCCVLWFTVIYDDPMH 239
Cdd:COG2223  110 SFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAA--FLAPLlIAAFGWRNAFLIL-GILLLVVAVLAWLFLRDPPAG 186

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568981785 240 HPcisvrekehitssvaqqSSSPRRSVPIKAMVRCLPLWAIFMGFFSHFWLCTIIITYLPTYISTVLHVNIRD 312
Cdd:COG2223  187 AA-----------------AAAKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAAT 242
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 83-194 1.41e-06

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 49.50  E-value: 1.41e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981785  83 VYQWSTETQGIIFSSISYGIILTLIPSGYLAGIFGAKQILGAGLLISSLLTLFTPLAADFGVILVIVIrtVQGMAQGMAW 162
Cdd:cd17325  229 LGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLA--LLGLGLGLVF 306

                         90       100       110
                 ....*....|....*....|....*....|..
gi 568981785 163 TGQFTIWAKWAPPLERSKLTSIAGSGEDVGSV 194
Cdd:cd17325  307 PATLALLADIVPPEGRGTAMGLFNTAFSLGMV 338
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
82-193 2.01e-06

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 48.82  E-value: 2.01e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981785  82 AVYQWSTETQGIIFSSISYGIILTLIPSGYLAGIFGAKQILGAGLLISSLLTLFTPLAADFGVILVIVIrtVQGMAQGMA 161
Cdd:COG2814  236 EVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALF--LLGFGFGLL 313

                         90       100       110
                 ....*....|....*....|....*....|..
gi 568981785 162 WTGQFTIWAKWAPPLERSKLTSIAGSGEDVGS 193
Cdd:COG2814  314 FPLLQALVAELAPPEARGRASGLYNSAFFLGG 345
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 87-308 2.43e-06

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 48.70  E-value: 2.43e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981785  87 STETQGIIFSSISYGIILTLIPSGYLAGIFGAKQILGAGLLISSLLTLFTPLAADFGVILVIviRTVQGMAQGMAWTGQF 166
Cdd:cd17324   32 SVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLA--RALAGLAHGGFWAIAA 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981785 167 TIWAKWAPPLERSKLTSIAGSGEDVGSvwVLHHPLCGRI-NLTGTGLAFYLLHLCIGCVCCVLWFTVIYDDPMHHPcisv 245
Cdd:cd17324  110 AYAADLVPPEKRGRAIGLVFSGLTLGL--VLGRPLGGLLgQLLGWRAAFLAIAVLALLAALLLWRLLPSLPPKKPG---- 183

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568981785 246 rekehITSSVAQQSSSPRRSVPIKAMVrclplwAIFMGFFSHFwlctIIITYLPTYISTVLHV 308
Cdd:cd17324  184 -----SLGLLSSLLLLLRNPRLRLAYL------ITFLLFGGFF----ALYTYLAPFLTDVPGF 231
MFS_GlpT cd17345
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ...
 84-193 7.27e-06

Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340903 [Multi-domain]  Cd Length: 411  Bit Score: 47.24  E-value: 7.27e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981785  84 YQWSTETQGIIFS--SISYGIILTLipSGYLAGIFGAKQILGAGLLISSLLTLF--TPLAADFGVILVIVIRTVQGMAQG 159
Cdd:cd17345   33 YGLSKTEIGLIGSalSIAYGLSKFV--MGNLSDRSNPKRFLAIGLILSAIINILigFVPSATSSVGLMFILLFLNGWFQG 110

                         90       100       110
                 ....*....|....*....|....*....|....
gi 568981785 160 MAWTGQFTIWAKWAPPLERSKLTSIAGSGEDVGS 193
Cdd:cd17345  111 MGWPPSGRTMVHWFSKKERGTWTSIWNISHNVGG 144
MFS_MT3072_like cd17475
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...
 81-313 2.70e-05

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341028 [Multi-domain]  Cd Length: 378  Bit Score: 45.69  E-value: 2.70e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981785  81 AAVYQWSTETQGIIFSSISYGIILTLIPSGYLAGIFGAKQILGAGLLISSLLTLFTPLAADFGVILVIVIrtVQGMAQGM 160
Cdd:cd17475   23 QEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLF--LVGAGYGS 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981785 161 AWTGQFTIWAKWAPPLERSKLTSIAGSGEDVGSVW--VLHHPLCGRINLTGTGLAFYLlhLCIGC-VCCVLWftviYDDP 237
Cdd:cd17475  101 VQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALaaALLPPLALHYGWRAAFVVAGL--VSILAaVLFWLF----YREP 174

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568981785 238 MhhpcisvrekehITSSVAQQSSSPRRSvpIKAMVRCLPLWAIfmgFFSHFWLCTI---IITYLPTYISTVLHVNIRDI 313
Cdd:cd17475  175 P------------AASAATESASTLLRS--LKEVLRNRDVWLI---AIAGALLVAPqfaLLTFLLLFLHDHLGLSVVAA 236
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 92-310 4.73e-05

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 44.89  E-value: 4.73e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981785  92 GIIFSSISYGIILTLIPSGYLAGIFGAKQILGAGLLISSLLTLFTPLAAdfGVILVIVIRTVQGMAQGMAWTGQFTIWAK 171
Cdd:cd17489   34 GLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLAT--SVALLLVLRLIHGIGWGAFTTAAATLVAD 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981785 172 WAPPLERSKLTSIAGSGEDVG-------SVWVLHHPLCGRINLTGTGLAFyllhlcIGCVCCVLwftviyddpmhhpcIS 244
Cdd:cd17489  112 IIPPSRRGEGIGYYGLATTLAmalgpalGLFLYQHLGFAVLFIVAAVLAL------LALLLVFL--------------VK 171

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568981785 245 VREKEHITSSVAQQSSSPRRSVPiKAMVRCLPLWAIFMGFFShfwlctiIITYLPTYISTVLHVNI 310
Cdd:cd17489  172 DPPPVAAEEAEAGTRAFRRLVEK-KVLPPALILFLASIAYGA-------ISTFLPLYAAERGISNA 229
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
82-309 2.19e-04

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 42.92  E-value: 2.19e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981785  82 AVYQWSTETQGIIFSSISYGIILTLIPSGYLAGIFGAKQILGAGLLISSLLTLFTPLAADFGVILVIVIrtVQGMAQGMA 161
Cdd:COG0738   36 DAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALF--LLGLGLGLL 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981785 162 WTGQFTIwAKWAPPLERSKLTSIAGSGEDVGSVWVlhhPLCG-RINLTGTGLAFYLLHLCIGCVCCVLWFTVIYddpmhh 240
Cdd:COG0738  114 DVAANPY-VAALGPETAASRLNLLHAFFSLGALLG---PLLGgLLILLGLSLSWHLPYLILAVLLLLLALLFLR------ 183

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568981785 241 pcISVREKEHITSSVAQQSSSPRRSVPIKAmvrclpLWAIFMGFFSHFWLCTIIITYLPTYISTVLHVN 309
Cdd:COG0738  184 --SKLPEIEEEEEEAAGSAASLKSLLKNPR------LLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLS 244
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 83-163 3.73e-04

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 41.77  E-value: 3.73e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981785  83 VYQWSTETQGIIFSSISYGIILTLIPSGYLAGIFGAKQILGAGLLISSL-LTLFTPLAADFGVILVIVIRTVQGMAQGMA 161
Cdd:cd17321  198 VLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVgLLLLALLGADSSVWLLLPGLVLLGLGLGLF 277


                 ..
gi 568981785 162 WT 163
Cdd:cd17321  278 AT 279
MFS_1 pfam07690
Major Facilitator Superfamily;
83-194 1.43e-03

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 40.09  E-value: 1.43e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981785   83 VYQWSTETQGIIFSSISYGIILTLIPSGYLAGIFGAKQILGAGLLISSLLTL-FTPLAADFGVILVIVIRTVQGMAQGMA 161
Cdd:pfam07690 229 VLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALgLLLLSLTLSSLWLLLALLLLGFGFGLV 308

                          90       100       110
                  ....*....|....*....|....*....|...
gi 568981785  162 WTGQFTIWAKWAPPLERSKLTSIAGSGEDVGSV 194
Cdd:pfam07690 309 FPALNALVSDLAPKEERGTASGLYNTAGSLGGA 341
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 87-192 3.12e-03

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 39.26  E-value: 3.12e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981785   87 STETQGIIFSSISYGIILTLIPSGYLAGIFGAKQILGAGLLISSLLTLFTPLAADFgvILVIVIRTVQGMAQGMAWTGQF 166
Cdd:TIGR00895  50 DPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNV--TQLLILRFLAGLGLGGLMPNLN 127

                          90       100
                  ....*....|....*....|....*.
gi 568981785  167 TIWAKWAPPLERSKLTSIAGSGEDVG 192
Cdd:TIGR00895 128 ALVSEYAPKRFRGTAVGLMFCGYPIG 153
efflux_EmrB TIGR00711
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ...
 76-240 3.15e-03

drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]


Pssm-ID: 129794 [Multi-domain]  Cd Length: 485  Bit Score: 39.28  E-value: 3.15e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981785   76 DFSTRAAVYQWSTetqgiifssISYGIIL-TLIP-SGYLAGIFGAKQILGAGLLISSLLTLFTPLAADFgvILVIVIRTV 153
Cdd:TIGR00711  31 DLGSSLSQVQWVI---------TSYMLANaISIPlTGWLAKRFGTRRLFLISTFAFTLGSLLCGVAPNL--ELMIIFRVI 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981785  154 QGMAQGMAWTGQFTIWAKWAPPLERSKLTSIAGSGedvgsvwVLHHPLCGRI------NLTGTGLAFYLLhLCIGC-VCC 226
Cdd:TIGR00711 100 QGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLT-------VLVAPALGPTlggwiiENYHWRWIFLIN-VPIGIiVVV 171

                         170
                  ....*....|....
gi 568981785  227 VLWFTVIYDDPMHH 240
Cdd:TIGR00711 172 VAFFILPRDKPAAS 185
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 75-188 3.33e-03

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 39.10  E-value: 3.33e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981785  75 KDFSTRAAVYQWSTetqgiifssISYGIIL-TLIP-SGYLAGIFGAKQILGAGLLISSLLTLFTPLAADFGVIlvIVIRT 152
Cdd:cd17503   24 GDLGASLDTVQWVI---------TSYLLALaIMIPlSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASL--IIFRI 92

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 568981785 153 VQGMAQGMAWTGQFTIWAKWAPPLERSKLTSIAGSG 188
Cdd:cd17503   93 LQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLV 128
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 83-232 3.75e-03

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 38.71  E-value: 3.75e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981785  83 VYQWSTETQGIIFSSISYGIILTLIPSGYLAGI-FGAKQILGAGLLISSLLTLFTPLAADFGVILVIVIrtVQGMAQGMA 161
Cdd:cd17474  228 LYGISPIIIGLLFAGWSVLLALGSLFVGRLLKKrFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIV--LFGLGLGLN 305

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568981785 162 WTGQFTIWAKWAPPLERSKLTSIAGSGEDVGSvwVLHHPLCGRINLTGTGLAFYLLHLCIGCVCCVLWFTV 232
Cdd:cd17474  306 LPLLTTLVTELAPEEERGTASSLYNFVRFLGQ--AVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLALL 374
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 87-194 7.81e-03

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 37.95  E-value: 7.81e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981785  87 STETQGIIFSSISYGIILTLIPSGYLAGIFGAKQILGAGLLISSLLTLFTPLAADFGVILVIviRTVQGMAQGMAWTGQF 166
Cdd:cd17365   32 SPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALL--RFLTGLGLGAAMPNAI 109

                         90       100
                 ....*....|....*....|....*...
gi 568981785 167 TIWAKWAPPLERSKLTSIAGSGEDVGSV 194
Cdd:cd17365  110 TLVSEYAPARRRSLAVTLMFCGYPLGAA 137
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 87-194 9.24e-03

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 37.58  E-value: 9.24e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981785  87 STETQGIIFSSISYGIILTLIPSGYLAGIFGAKQILGAGLLISSLLTLFTPLAADFgvILVIVIRTVQGMAQGMAWTGQF 166
Cdd:cd17316   34 SLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTP--ILLLVLRFLQGIGIGGEYPGAS 111

                         90       100
                 ....*....|....*....|....*...
gi 568981785 167 TIWAKWAPPLERSKLTSIAGSGEDVGSV 194
Cdd:cd17316  112 TYVAEFAPSKRRGFALGLLQSGWALGAL 139
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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