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Conserved domains on  [gi|568983733|ref|XP_006517488|]
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centrosomal protein of 72 kDa isoform X6 [Mus musculus]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 1903219)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PPP1R42 super family cl42388
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 42-144 1.07e-13

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


The actual alignment was detected with superfamily member cd21340:

Pssm-ID: 455733 [Multi-domain]  Cd Length: 220  Bit Score: 70.59  E-value: 1.07e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568983733  42 ITHLGNSLMHLtalkslDLSRNSLVSLEGIQYLVSLESLNLYYNCISSLAEVFR-LHTLLELQDVDFRLNPVVKNeSDYR 120
Cdd:cd21340  115 LAALSNSLRVL------NISGNNIDSLEPLAPLRNLEQLDASNNQISDLEELLDlLSSWPSLRELDLTGNPVCKK-PKYR 187

                         90       100
                 ....*....|....*....|....
gi 568983733 121 LFVVHMLPKLRQLDDRPVRESERK 144
Cdd:cd21340  188 DKIILASKSLEVLDGKEITDTERQ 211
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 42-144 1.07e-13

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 70.59  E-value: 1.07e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568983733  42 ITHLGNSLMHLtalkslDLSRNSLVSLEGIQYLVSLESLNLYYNCISSLAEVFR-LHTLLELQDVDFRLNPVVKNeSDYR 120
Cdd:cd21340  115 LAALSNSLRVL------NISGNNIDSLEPLAPLRNLEQLDASNNQISDLEELLDlLSSWPSLRELDLTGNPVCKK-PKYR 187

                         90       100
                 ....*....|....*....|....
gi 568983733 121 LFVVHMLPKLRQLDDRPVRESERK 144
Cdd:cd21340  188 DKIILASKSLEVLDGKEITDTERQ 211
LRR_9 pfam14580
Leucine-rich repeat;
51-150 2.35e-11

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 62.47  E-value: 2.35e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568983733   51 HLTALKSLDLSRNSLVSL-EGI-QYLVSLESLNLYYNCISSLAEVFRLHTLLELQDVDFRLNPVVkNESDYRLFVVHMLP 128
Cdd:pfam14580  62 LLRRLKTLLLNNNRICRIgEGLgEALPNLTELILTNNNLQELGDLDPLASLKKLTFLSLLRNPVT-NKPHYRLYVIYKVP 140

                          90       100
                  ....*....|....*....|..
gi 568983733  129 KLRQLDDRPVRESERKASQLHF 150
Cdd:pfam14580 141 QLRLLDFRKVKQKERQAAEKMF 162
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
25-112 8.32e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 61.10  E-value: 8.32e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568983733  25 DLAELRSLSIPGTyqeKITHLGNSLMHLTALKSLDLSRNSLVSLEGIQYLVSLESLNLYYNCISSLAEVFRLHtllELQD 104
Cdd:COG4886  203 NLTNLEELDLSGN---QLTDLPEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANLT---NLKT 276


                 ....*...
gi 568983733 105 VDFRLNPV 112
Cdd:COG4886  277 LDLSNNQL 284
LRRcap smart00446
occurring C-terminal to leucine-rich repeats; A motif occurring C-terminal to leucine-rich ...
 117-134 1.09e-03

occurring C-terminal to leucine-rich repeats; A motif occurring C-terminal to leucine-rich repeats in "sds22-like" and "typical" LRR-containing proteins.


Pssm-ID: 197729  Cd Length: 19  Bit Score: 36.52  E-value: 1.09e-03
                           10
                   ....*....|....*...
gi 568983733   117 SDYRLFVVHMLPKLRQLD 134
Cdd:smart00446   2 AHYREKVIELLPQLRKLD 19
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 42-144 1.07e-13

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 70.59  E-value: 1.07e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568983733  42 ITHLGNSLMHLtalkslDLSRNSLVSLEGIQYLVSLESLNLYYNCISSLAEVFR-LHTLLELQDVDFRLNPVVKNeSDYR 120
Cdd:cd21340  115 LAALSNSLRVL------NISGNNIDSLEPLAPLRNLEQLDASNNQISDLEELLDlLSSWPSLRELDLTGNPVCKK-PKYR 187

                         90       100
                 ....*....|....*....|....
gi 568983733 121 LFVVHMLPKLRQLDDRPVRESERK 144
Cdd:cd21340  188 DKIILASKSLEVLDGKEITDTERQ 211
LRR_9 pfam14580
Leucine-rich repeat;
51-150 2.35e-11

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 62.47  E-value: 2.35e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568983733   51 HLTALKSLDLSRNSLVSL-EGI-QYLVSLESLNLYYNCISSLAEVFRLHTLLELQDVDFRLNPVVkNESDYRLFVVHMLP 128
Cdd:pfam14580  62 LLRRLKTLLLNNNRICRIgEGLgEALPNLTELILTNNNLQELGDLDPLASLKKLTFLSLLRNPVT-NKPHYRLYVIYKVP 140

                          90       100
                  ....*....|....*....|..
gi 568983733  129 KLRQLDDRPVRESERKASQLHF 150
Cdd:pfam14580 141 QLRLLDFRKVKQKERQAAEKMF 162
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
25-112 8.32e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 61.10  E-value: 8.32e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568983733  25 DLAELRSLSIPGTyqeKITHLGNSLMHLTALKSLDLSRNSLVSLEGIQYLVSLESLNLYYNCISSLAEVFRLHtllELQD 104
Cdd:COG4886  203 NLTNLEELDLSGN---QLTDLPEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANLT---NLKT 276


                 ....*...
gi 568983733 105 VDFRLNPV 112
Cdd:COG4886  277 LDLSNNQL 284
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
25-102 3.10e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 59.18  E-value: 3.10e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568983733  25 DLAELRSLSIPGTyqeKITHLGNSLMHLTALKSLDLSRNSLVSL-EGIQYLVSLESLNLYYNCISSLAEVF-RLHTLLEL 102
Cdd:COG4886  134 NLTNLKELDLSNN---QLTDLPEPLGNLTNLKSLDLSNNQLTDLpEELGNLTNLKELDLSNNQITDLPEPLgNLTNLEEL 210
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
25-102 1.85e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 56.87  E-value: 1.85e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568983733  25 DLAELRSLSIPGTyqeKITHLGNSLMHLTALKSLDLSRNSLVSL-EGIQYLVSLESLNLYYNCISSLAEVFRLHTLLEL 102
Cdd:COG4886  180 NLTNLKELDLSNN---QITDLPEPLGNLTNLEELDLSGNQLTDLpEPLANLTNLETLDLSNNQLTDLPELGNLTNLEEL 255
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
18-102 2.92e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 56.10  E-value: 2.92e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568983733  18 SGLGPHRDLAELRSLSIPGTyqeKITHLGNSLMHLTALKSLDLSRNSLVSL-EGIQYLVSLESLNLYYNCISSL-AEVFR 95
Cdd:COG4886  104 SGNEELSNLTNLESLDLSGN---QLTDLPEELANLTNLKELDLSNNQLTDLpEPLGNLTNLKSLDLSNNQLTDLpEELGN 180


                 ....*..
gi 568983733  96 LHTLLEL 102
Cdd:COG4886  181 LTNLKEL 187
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
25-90 1.27e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 44.54  E-value: 1.27e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568983733  25 DLAELRSLSIPGTyqeKITHLGnSLMHLTALKSLDLSRNSLVSLEGIQYLVSLESLNLYYNCISSL 90
Cdd:COG4886  226 NLTNLETLDLSNN---QLTDLP-ELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDL 287
LRR_8 pfam13855
Leucine rich repeat;
28-85 4.80e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 38.27  E-value: 4.80e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568983733   28 ELRSLSIPGTYqekITHLGN-SLMHLTALKSLDLSRNSLVSLEG--IQYLVSLESLNLYYN 85
Cdd:pfam13855   2 NLRSLDLSNNR---LTSLDDgAFKGLSNLKVLDLSNNLLTTLSPgaFSGLPSLRYLDLSGN 59
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 40-103 9.29e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 40.92  E-value: 9.29e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568983733  40 EKITHLGNslmhLTALKSLDLSRNSLVSLEGIQYLVSLESLNLYYNCISSLAEVFRLHTLLELQ 103
Cdd:cd21340   37 TKIENLEF----LTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISVVEGLENLTNLEELH 96
LRR_8 pfam13855
Leucine rich repeat;
55-90 1.09e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.50  E-value: 1.09e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 568983733   55 LKSLDLSRNSLVSLEG--IQYLVSLESLNLYYNCISSL 90
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDgaFKGLSNLKVLDLSNNLLTTL 40
LRRcap smart00446
occurring C-terminal to leucine-rich repeats; A motif occurring C-terminal to leucine-rich ...
 117-134 1.09e-03

occurring C-terminal to leucine-rich repeats; A motif occurring C-terminal to leucine-rich repeats in "sds22-like" and "typical" LRR-containing proteins.


Pssm-ID: 197729  Cd Length: 19  Bit Score: 36.52  E-value: 1.09e-03
                           10
                   ....*....|....*...
gi 568983733   117 SDYRLFVVHMLPKLRQLD 134
Cdd:smart00446   2 AHYREKVIELLPQLRKLD 19
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 53-85 1.57e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 36.45  E-value: 1.57e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 568983733   53 TALKSLDLSRNSLVSLEGIQYLVSLESLNLYYN 85
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKLPNLETLDLSGN 33
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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