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Conserved domains on  [gi|568994882|ref|XP_006521978|]
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transmembrane protease serine 7 isoform X1 [Mus musculus]

Protein Classification

neuropilin and tolloid-like protein; LDL receptor domain-containing protein( domain architecture ID 12017915)

neuropilin and tolloid-like protein is a CUB and LDLa (low-density lipoprotein receptor class A) domain-containing protein similar to Homo sapiens neuropilin and tolloid-like protein 1 involved in the development and/or maintenance of neuronal circuitry| Low Density Lipoprotein (LDL) receptor class A domain is a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; similar to Bos taurus CD320 antigen

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Tryp_SPc smart00020
Trypsin-like serine protease; Many of these are synthesised as inactive precursor zymogens ...
 591-821 1.87e-91

Trypsin-like serine protease; Many of these are synthesised as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. A few, however, are active as single chain molecules, and others are inactive due to substitutions of the catalytic triad residues.


:

Pssm-ID: 214473  Cd Length: 229  Bit Score: 287.27  E-value: 1.87e-91
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994882   591 RIVGGSDSQEGTWPWQVSLHF-VGSAYCGASVISREWLLSAAHCFHGNRLSDptpWTAHLGMY--VQGNAKFISPVRRIV 667
Cdd:smart00020   1 RIVGGSEANIGSFPWQVSLQYgGGRHFCGGSLISPRWVLTAAHCVRGSDPSN---IRVRLGSHdlSSGEEGQVIKVSKVI 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994882   668 VHEYYNSQTFDYDIALLQLSiaWPETLKQLIQPICIPPAGQKVRSGEKCWVTGWGRRHEADSKGSPVLQQAEVELIDQTV 747
Cdd:smart00020  78 IHPNYNPSTYDNDIALLKLK--EPVTLSDNVRPICLPSSNYNVPAGTTCTVSGWGRTSEGAGSLPDTLQEVNVPIVSNAT 155

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568994882   748 CVSTYG---IITSRMLCAGVMSGKSDACKGDSGGPLSCRrksDGKWILTGIVSWGHGCGRPNFPGVYTRVSSFVPWI 821
Cdd:smart00020 156 CRRAYSgggAITDNMLCAGGLEGGKDACQGDSGGPLVCN---DGRWVLVGIVSWGSGCARPGKPGVYTRVSSYLDWI 229
SEA pfam01390
SEA domain; Domain found in Sea urchin sperm protein, Enterokinase, Agrin (SEA). Proposed ...
 94-193 9.39e-23

SEA domain; Domain found in Sea urchin sperm protein, Enterokinase, Agrin (SEA). Proposed function of regulating or binding carbohydrate side chains. Recently a proteolytic activity has been shown for a SEA domain.


:

Pssm-ID: 460188  Cd Length: 100  Bit Score: 93.46  E-value: 9.39e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994882   94 FYFVGMFRITNIEFLPEYRQKESREFLSMAKTVQQVVNLVYTTSAFSKFYKQSVVADVsSNNKGGLLVHFWIVFVMPHAK 173
Cdd:pfam01390   1 QYYTGSFKITNLQYTPDLGNPSSQEFKSLSRRIESLLNELFRNSSLRKQYIKSHVLRL-RPDGGSVVVDVVLVFRFPSTE 79

                          90       100
                  ....*....|....*....|
gi 568994882  174 GHIFCEECVAAILKDSIQTS 193
Cdd:pfam01390  80 PALDREKLIEEILRQTLNNT 99
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 470-504 3.78e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 58.37  E-value: 3.78e-11
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 568994882 470 CPAGSFRCSSGLCVPQAQRCDGVNDCFDESDELFC 504
Cdd:cd00112    1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 257-345 2.08e-08

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


:

Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 52.80  E-value: 2.08e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994882 257 LMCHFKLVAIVGYLIRLSIESIQLEAD-NCITDSLTVYDSlLPIRSAILYRICEpTRTLMSFVSTNNLMLVILKSPYVRR 335
Cdd:cd00041   26 LNCVWTIEAPPGYRIRLTFEDFDLESSpNCSYDYLEIYDG-PSTSSPLLGRFCG-STLPPPIISSGNSLTVRFRSDSSVT 103

                         90
                 ....*....|
gi 568994882 336 LAGIRAYFEV 345
Cdd:cd00041  104 GRGFKATYSA 113
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 545-580 4.03e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 49.51  E-value: 4.03e-08
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 568994882 545 CTSRTFKCGNDICFRKqNAQCDGIVDCPDGSDEEGC 580
Cdd:cd00112    1 CPPNEFRCANGRCIPS-SWVCDGEDDCGDGSDEENC 35
 
Name Accession Description Interval E-value
Tryp_SPc smart00020
Trypsin-like serine protease; Many of these are synthesised as inactive precursor zymogens ...
 591-821 1.87e-91

Trypsin-like serine protease; Many of these are synthesised as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. A few, however, are active as single chain molecules, and others are inactive due to substitutions of the catalytic triad residues.


Pssm-ID: 214473  Cd Length: 229  Bit Score: 287.27  E-value: 1.87e-91
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994882   591 RIVGGSDSQEGTWPWQVSLHF-VGSAYCGASVISREWLLSAAHCFHGNRLSDptpWTAHLGMY--VQGNAKFISPVRRIV 667
Cdd:smart00020   1 RIVGGSEANIGSFPWQVSLQYgGGRHFCGGSLISPRWVLTAAHCVRGSDPSN---IRVRLGSHdlSSGEEGQVIKVSKVI 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994882   668 VHEYYNSQTFDYDIALLQLSiaWPETLKQLIQPICIPPAGQKVRSGEKCWVTGWGRRHEADSKGSPVLQQAEVELIDQTV 747
Cdd:smart00020  78 IHPNYNPSTYDNDIALLKLK--EPVTLSDNVRPICLPSSNYNVPAGTTCTVSGWGRTSEGAGSLPDTLQEVNVPIVSNAT 155

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568994882   748 CVSTYG---IITSRMLCAGVMSGKSDACKGDSGGPLSCRrksDGKWILTGIVSWGHGCGRPNFPGVYTRVSSFVPWI 821
Cdd:smart00020 156 CRRAYSgggAITDNMLCAGGLEGGKDACQGDSGGPLVCN---DGRWVLVGIVSWGSGCARPGKPGVYTRVSSYLDWI 229
Tryp_SPc cd00190
Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens ...
 592-823 2.04e-90

Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad residues.


Pssm-ID: 238113 [Multi-domain]  Cd Length: 232  Bit Score: 284.55  E-value: 2.04e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994882 592 IVGGSDSQEGTWPWQVSLHF-VGSAYCGASVISREWLLSAAHCFHGnrlSDPTPWTAHLGMYVQGNAKF---ISPVRRIV 667
Cdd:cd00190    1 IVGGSEAKIGSFPWQVSLQYtGGRHFCGGSLISPRWVLTAAHCVYS---SAPSNYTVRLGSHDLSSNEGggqVIKVKKVI 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994882 668 VHEYYNSQTFDYDIALLQLSiaWPETLKQLIQPICIPPAGQKVRSGEKCWVTGWGRRHEaDSKGSPVLQQAEVELIDQTV 747
Cdd:cd00190   78 VHPNYNPSTYDNDIALLKLK--RPVTLSDNVRPICLPSSGYNLPAGTTCTVSGWGRTSE-GGPLPDVLQEVNVPIVSNAE 154

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568994882 748 CVSTY---GIITSRMLCAGVMSGKSDACKGDSGGPLSCrrKSDGKWILTGIVSWGHGCGRPNFPGVYTRVSSFVPWIHK 823
Cdd:cd00190  155 CKRAYsygGTITDNMLCAGGLEGGKDACQGDSGGPLVC--NDNGRGVLVGIVSWGSGCARPNYPGVYTRVSSYLDWIQK 231
COG5640 COG5640
Secreted trypsin-like serine protease [Posttranslational modification, protein turnover, ...
 591-828 3.12e-70

Secreted trypsin-like serine protease [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 444365 [Multi-domain]  Cd Length: 262  Bit Score: 232.23  E-value: 3.12e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994882 591 RIVGGSDSQEGTWPWQVSLHFVG---SAYCGASVISREWLLSAAHCFHGNRLSDptpWTAHLGMY-VQGNAKFISPVRRI 666
Cdd:COG5640   30 AIVGGTPATVGEYPWMVALQSSNgpsGQFCGGTLIAPRWVLTAAHCVDGDGPSD---LRVVIGSTdLSTSGGTVVKVARI 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994882 667 VVHEYYNSQTFDYDIALLQLSIAWPEtlkqlIQPICIPPAGQKVRSGEKCWVTGWGRRHEADSKGSPVLQQAEVELIDQT 746
Cdd:COG5640  107 VVHPDYDPATPGNDIALLKLATPVPG-----VAPAPLATSADAAAPGTPATVAGWGRTSEGPGSQSGTLRKADVPVVSDA 181

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994882 747 VCVSTYGIITSRMLCAGVMSGKSDACKGDSGGPLscRRKSDGKWILTGIVSWGHGCGRPNFPGVYTRVSSFVPWIHKYVP 826
Cdd:COG5640  182 TCAAYGGFDGGTMLCAGYPEGGKDACQGDSGGPL--VVKDGGGWVLVGVVSWGGGPCAAGYPGVYTRVSAYRDWIKSTAG 259


                 ..
gi 568994882 827 SL 828
Cdd:COG5640  260 GL 261
Trypsin pfam00089
Trypsin;
592-821 3.38e-67

Trypsin;


Pssm-ID: 459667 [Multi-domain]  Cd Length: 219  Bit Score: 222.32  E-value: 3.38e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994882  592 IVGGSDSQEGTWPWQVSLHFVGSAY-CGASVISREWLLSAAHCFHGNrlSDPTPWT-AHLGMYVQGNAKFIsPVRRIVVH 669
Cdd:pfam00089   1 IVGGDEAQPGSFPWQVSLQLSSGKHfCGGSLISENWVLTAAHCVSGA--SDVKVVLgAHNIVLREGGEQKF-DVEKIIVH 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994882  670 EYYNSQTFDYDIALLQLSIawPETLKQLIQPICIPPAGQKVRSGEKCWVTGWGRrhEADSKGSPVLQQAEVELIDQTVCV 749
Cdd:pfam00089  78 PNYNPDTLDNDIALLKLES--PVTLGDTVRPICLPDASSDLPVGTTCTVSGWGN--TKTLGPSDTLQEVTVPVVSRETCR 153

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568994882  750 STYGI-ITSRMLCAGvmSGKSDACKGDSGGPLSCRRKsdgkwILTGIVSWGHGCGRPNFPGVYTRVSSFVPWI 821
Cdd:pfam00089 154 SAYGGtVTDTMICAG--AGGKDACQGDSGGPLVCSDG-----ELIGIVSWGYGCASGNYPGVYTPVSSYLDWI 219
SEA pfam01390
SEA domain; Domain found in Sea urchin sperm protein, Enterokinase, Agrin (SEA). Proposed ...
 94-193 9.39e-23

SEA domain; Domain found in Sea urchin sperm protein, Enterokinase, Agrin (SEA). Proposed function of regulating or binding carbohydrate side chains. Recently a proteolytic activity has been shown for a SEA domain.


Pssm-ID: 460188  Cd Length: 100  Bit Score: 93.46  E-value: 9.39e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994882   94 FYFVGMFRITNIEFLPEYRQKESREFLSMAKTVQQVVNLVYTTSAFSKFYKQSVVADVsSNNKGGLLVHFWIVFVMPHAK 173
Cdd:pfam01390   1 QYYTGSFKITNLQYTPDLGNPSSQEFKSLSRRIESLLNELFRNSSLRKQYIKSHVLRL-RPDGGSVVVDVVLVFRFPSTE 79

                          90       100
                  ....*....|....*....|
gi 568994882  174 GHIFCEECVAAILKDSIQTS 193
Cdd:pfam01390  80 PALDREKLIEEILRQTLNNT 99
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 470-504 3.78e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 58.37  E-value: 3.78e-11
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 568994882 470 CPAGSFRCSSGLCVPQAQRCDGVNDCFDESDELFC 504
Cdd:cd00112    1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 470-501 5.55e-11

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 57.64  E-value: 5.55e-11
                           10        20        30
                   ....*....|....*....|....*....|..
gi 568994882   470 CPAGSFRCSSGLCVPQAQRCDGVNDCFDESDE 501
Cdd:smart00192   2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 257-345 2.08e-08

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 52.80  E-value: 2.08e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994882 257 LMCHFKLVAIVGYLIRLSIESIQLEAD-NCITDSLTVYDSlLPIRSAILYRICEpTRTLMSFVSTNNLMLVILKSPYVRR 335
Cdd:cd00041   26 LNCVWTIEAPPGYRIRLTFEDFDLESSpNCSYDYLEIYDG-PSTSSPLLGRFCG-STLPPPIISSGNSLTVRFRSDSSVT 103

                         90
                 ....*....|
gi 568994882 336 LAGIRAYFEV 345
Cdd:cd00041  104 GRGFKATYSA 113
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 545-580 4.03e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 49.51  E-value: 4.03e-08
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 568994882 545 CTSRTFKCGNDICFRKqNAQCDGIVDCPDGSDEEGC 580
Cdd:cd00112    1 CPPNEFRCANGRCIPS-SWVCDGEDDCGDGSDEENC 35
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
469-504 5.79e-08

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 49.17  E-value: 5.79e-08
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 568994882  469 PCPAGSFRCSSGLCVPQAQRCDGVNDCFDESDELFC 504
Cdd:pfam00057   2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 545-577 6.09e-07

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 46.47  E-value: 6.09e-07
                           10        20        30
                   ....*....|....*....|....*....|...
gi 568994882   545 CTSRTFKCGNDICfRKQNAQCDGIVDCPDGSDE 577
Cdd:smart00192   2 CPPGEFQCDNGRC-IPSSWVCDGVDDCGDGSDE 33
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 259-343 2.31e-06

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 46.61  E-value: 2.31e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994882   259 CHFKLVAIVGYLIRLSIESIQLEA-DNCITDSLTVYDSlLPIRSAILYRICEPTRTLMSFVSTNNLMLVILKSPYVRRLA 337
Cdd:smart00042  18 CVWTIRAPPGYRIELQFTDFDLESsDNCEYDYVEIYDG-PSASSPLLGRFCGSEAPPPVISSSSNSLTLTFVSDSSVQKR 96


                   ....*.
gi 568994882   338 GIRAYF 343
Cdd:smart00042  97 GFSARY 102
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
544-580 7.27e-06

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 43.39  E-value: 7.27e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 568994882  544 PCTSRTFKCGNDICFrKQNAQCDGIVDCPDGSDEEGC 580
Cdd:pfam00057   2 TCSPNEFQCGSGECI-PRSWVCDGDPDCGDGSDEENC 37
CUB pfam00431
CUB domain;
259-343 3.65e-03

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 38.04  E-value: 3.65e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994882  259 CHFKLVAIVGYLIRLSIESIQLEA-DNCITDSLTVYDSllPIRSAILY-RICEPTRTLmSFVSTNNLMLVILKSPYVRRL 336
Cdd:pfam00431  27 CVWLIRAPPGFRVKLTFQDFELEDhDECGYDYVEIRDG--PSASSPLLgRFCGSGIPE-DIVSSSNQMTIKFVSDASVQK 103


                  ....*..
gi 568994882  337 AGIRAYF 343
Cdd:pfam00431 104 RGFKATY 110
 
Name Accession Description Interval E-value
Tryp_SPc smart00020
Trypsin-like serine protease; Many of these are synthesised as inactive precursor zymogens ...
 591-821 1.87e-91

Trypsin-like serine protease; Many of these are synthesised as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. A few, however, are active as single chain molecules, and others are inactive due to substitutions of the catalytic triad residues.


Pssm-ID: 214473  Cd Length: 229  Bit Score: 287.27  E-value: 1.87e-91
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994882   591 RIVGGSDSQEGTWPWQVSLHF-VGSAYCGASVISREWLLSAAHCFHGNRLSDptpWTAHLGMY--VQGNAKFISPVRRIV 667
Cdd:smart00020   1 RIVGGSEANIGSFPWQVSLQYgGGRHFCGGSLISPRWVLTAAHCVRGSDPSN---IRVRLGSHdlSSGEEGQVIKVSKVI 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994882   668 VHEYYNSQTFDYDIALLQLSiaWPETLKQLIQPICIPPAGQKVRSGEKCWVTGWGRRHEADSKGSPVLQQAEVELIDQTV 747
Cdd:smart00020  78 IHPNYNPSTYDNDIALLKLK--EPVTLSDNVRPICLPSSNYNVPAGTTCTVSGWGRTSEGAGSLPDTLQEVNVPIVSNAT 155

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568994882   748 CVSTYG---IITSRMLCAGVMSGKSDACKGDSGGPLSCRrksDGKWILTGIVSWGHGCGRPNFPGVYTRVSSFVPWI 821
Cdd:smart00020 156 CRRAYSgggAITDNMLCAGGLEGGKDACQGDSGGPLVCN---DGRWVLVGIVSWGSGCARPGKPGVYTRVSSYLDWI 229
Tryp_SPc cd00190
Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens ...
 592-823 2.04e-90

Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad residues.


Pssm-ID: 238113 [Multi-domain]  Cd Length: 232  Bit Score: 284.55  E-value: 2.04e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994882 592 IVGGSDSQEGTWPWQVSLHF-VGSAYCGASVISREWLLSAAHCFHGnrlSDPTPWTAHLGMYVQGNAKF---ISPVRRIV 667
Cdd:cd00190    1 IVGGSEAKIGSFPWQVSLQYtGGRHFCGGSLISPRWVLTAAHCVYS---SAPSNYTVRLGSHDLSSNEGggqVIKVKKVI 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994882 668 VHEYYNSQTFDYDIALLQLSiaWPETLKQLIQPICIPPAGQKVRSGEKCWVTGWGRRHEaDSKGSPVLQQAEVELIDQTV 747
Cdd:cd00190   78 VHPNYNPSTYDNDIALLKLK--RPVTLSDNVRPICLPSSGYNLPAGTTCTVSGWGRTSE-GGPLPDVLQEVNVPIVSNAE 154

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568994882 748 CVSTY---GIITSRMLCAGVMSGKSDACKGDSGGPLSCrrKSDGKWILTGIVSWGHGCGRPNFPGVYTRVSSFVPWIHK 823
Cdd:cd00190  155 CKRAYsygGTITDNMLCAGGLEGGKDACQGDSGGPLVC--NDNGRGVLVGIVSWGSGCARPNYPGVYTRVSSYLDWIQK 231
COG5640 COG5640
Secreted trypsin-like serine protease [Posttranslational modification, protein turnover, ...
 591-828 3.12e-70

Secreted trypsin-like serine protease [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 444365 [Multi-domain]  Cd Length: 262  Bit Score: 232.23  E-value: 3.12e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994882 591 RIVGGSDSQEGTWPWQVSLHFVG---SAYCGASVISREWLLSAAHCFHGNRLSDptpWTAHLGMY-VQGNAKFISPVRRI 666
Cdd:COG5640   30 AIVGGTPATVGEYPWMVALQSSNgpsGQFCGGTLIAPRWVLTAAHCVDGDGPSD---LRVVIGSTdLSTSGGTVVKVARI 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994882 667 VVHEYYNSQTFDYDIALLQLSIAWPEtlkqlIQPICIPPAGQKVRSGEKCWVTGWGRRHEADSKGSPVLQQAEVELIDQT 746
Cdd:COG5640  107 VVHPDYDPATPGNDIALLKLATPVPG-----VAPAPLATSADAAAPGTPATVAGWGRTSEGPGSQSGTLRKADVPVVSDA 181

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994882 747 VCVSTYGIITSRMLCAGVMSGKSDACKGDSGGPLscRRKSDGKWILTGIVSWGHGCGRPNFPGVYTRVSSFVPWIHKYVP 826
Cdd:COG5640  182 TCAAYGGFDGGTMLCAGYPEGGKDACQGDSGGPL--VVKDGGGWVLVGVVSWGGGPCAAGYPGVYTRVSAYRDWIKSTAG 259


                 ..
gi 568994882 827 SL 828
Cdd:COG5640  260 GL 261
Trypsin pfam00089
Trypsin;
592-821 3.38e-67

Trypsin;


Pssm-ID: 459667 [Multi-domain]  Cd Length: 219  Bit Score: 222.32  E-value: 3.38e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994882  592 IVGGSDSQEGTWPWQVSLHFVGSAY-CGASVISREWLLSAAHCFHGNrlSDPTPWT-AHLGMYVQGNAKFIsPVRRIVVH 669
Cdd:pfam00089   1 IVGGDEAQPGSFPWQVSLQLSSGKHfCGGSLISENWVLTAAHCVSGA--SDVKVVLgAHNIVLREGGEQKF-DVEKIIVH 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994882  670 EYYNSQTFDYDIALLQLSIawPETLKQLIQPICIPPAGQKVRSGEKCWVTGWGRrhEADSKGSPVLQQAEVELIDQTVCV 749
Cdd:pfam00089  78 PNYNPDTLDNDIALLKLES--PVTLGDTVRPICLPDASSDLPVGTTCTVSGWGN--TKTLGPSDTLQEVTVPVVSRETCR 153

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568994882  750 STYGI-ITSRMLCAGvmSGKSDACKGDSGGPLSCRRKsdgkwILTGIVSWGHGCGRPNFPGVYTRVSSFVPWI 821
Cdd:pfam00089 154 SAYGGtVTDTMICAG--AGGKDACQGDSGGPLVCSDG-----ELIGIVSWGYGCASGNYPGVYTPVSSYLDWI 219
SEA pfam01390
SEA domain; Domain found in Sea urchin sperm protein, Enterokinase, Agrin (SEA). Proposed ...
 94-193 9.39e-23

SEA domain; Domain found in Sea urchin sperm protein, Enterokinase, Agrin (SEA). Proposed function of regulating or binding carbohydrate side chains. Recently a proteolytic activity has been shown for a SEA domain.


Pssm-ID: 460188  Cd Length: 100  Bit Score: 93.46  E-value: 9.39e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994882   94 FYFVGMFRITNIEFLPEYRQKESREFLSMAKTVQQVVNLVYTTSAFSKFYKQSVVADVsSNNKGGLLVHFWIVFVMPHAK 173
Cdd:pfam01390   1 QYYTGSFKITNLQYTPDLGNPSSQEFKSLSRRIESLLNELFRNSSLRKQYIKSHVLRL-RPDGGSVVVDVVLVFRFPSTE 79

                          90       100
                  ....*....|....*....|
gi 568994882  174 GHIFCEECVAAILKDSIQTS 193
Cdd:pfam01390  80 PALDREKLIEEILRQTLNNT 99
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 470-504 3.78e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 58.37  E-value: 3.78e-11
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 568994882 470 CPAGSFRCSSGLCVPQAQRCDGVNDCFDESDELFC 504
Cdd:cd00112    1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 470-501 5.55e-11

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 57.64  E-value: 5.55e-11
                           10        20        30
                   ....*....|....*....|....*....|..
gi 568994882   470 CPAGSFRCSSGLCVPQAQRCDGVNDCFDESDE 501
Cdd:smart00192   2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 257-345 2.08e-08

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 52.80  E-value: 2.08e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994882 257 LMCHFKLVAIVGYLIRLSIESIQLEAD-NCITDSLTVYDSlLPIRSAILYRICEpTRTLMSFVSTNNLMLVILKSPYVRR 335
Cdd:cd00041   26 LNCVWTIEAPPGYRIRLTFEDFDLESSpNCSYDYLEIYDG-PSTSSPLLGRFCG-STLPPPIISSGNSLTVRFRSDSSVT 103

                         90
                 ....*....|
gi 568994882 336 LAGIRAYFEV 345
Cdd:cd00041  104 GRGFKATYSA 113
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 545-580 4.03e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 49.51  E-value: 4.03e-08
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 568994882 545 CTSRTFKCGNDICFRKqNAQCDGIVDCPDGSDEEGC 580
Cdd:cd00112    1 CPPNEFRCANGRCIPS-SWVCDGEDDCGDGSDEENC 35
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
469-504 5.79e-08

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 49.17  E-value: 5.79e-08
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 568994882  469 PCPAGSFRCSSGLCVPQAQRCDGVNDCFDESDELFC 504
Cdd:pfam00057   2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 545-577 6.09e-07

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 46.47  E-value: 6.09e-07
                           10        20        30
                   ....*....|....*....|....*....|...
gi 568994882   545 CTSRTFKCGNDICfRKQNAQCDGIVDCPDGSDE 577
Cdd:smart00192   2 CPPGEFQCDNGRC-IPSSWVCDGVDDCGDGSDE 33
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 259-343 2.31e-06

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 46.61  E-value: 2.31e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994882   259 CHFKLVAIVGYLIRLSIESIQLEA-DNCITDSLTVYDSlLPIRSAILYRICEPTRTLMSFVSTNNLMLVILKSPYVRRLA 337
Cdd:smart00042  18 CVWTIRAPPGYRIELQFTDFDLESsDNCEYDYVEIYDG-PSASSPLLGRFCGSEAPPPVISSSSNSLTLTFVSDSSVQKR 96


                   ....*.
gi 568994882   338 GIRAYF 343
Cdd:smart00042  97 GFSARY 102
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
544-580 7.27e-06

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 43.39  E-value: 7.27e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 568994882  544 PCTSRTFKCGNDICFrKQNAQCDGIVDCPDGSDEEGC 580
Cdd:pfam00057   2 TCSPNEFQCGSGECI-PRSWVCDGDPDCGDGSDEENC 37
CUB pfam00431
CUB domain;
259-343 3.65e-03

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 38.04  E-value: 3.65e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994882  259 CHFKLVAIVGYLIRLSIESIQLEA-DNCITDSLTVYDSllPIRSAILY-RICEPTRTLmSFVSTNNLMLVILKSPYVRRL 336
Cdd:pfam00431  27 CVWLIRAPPGFRVKLTFQDFELEDhDECGYDYVEIRDG--PSASSPLLgRFCGSGIPE-DIVSSSNQMTIKFVSDASVQK 103


                  ....*..
gi 568994882  337 AGIRAYF 343
Cdd:pfam00431 104 RGFKATY 110
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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