NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|568996558|ref|XP_006522780|]
View 

protein HEG homolog 1 isoform X3 [Mus musculus]

Protein Classification

calcium-binding EGF-like domain-containing protein; wall-associated receptor kinase family protein( domain architecture ID 10043351)

calcium-binding epidermal growth factor (EGF)-like domain-containing protein may play a crucial role in numerous protein-protein interactions| wall-associated receptor kinase (WAK) family protein containing the calcium-binding EGF and serine/threonine kinase domains but lacking the WAK galacturonan-binding domain, catalyzes the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates, and may function as a signaling receptor of extracellular matrix component

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
EGF_CA smart00179
Calcium-binding EGF-like domain;
1054-1085 1.31e-10

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 57.26  E-value: 1.31e-10
                            10        20        30
                    ....*....|....*....|....*....|...
gi 568996558   1054 DVNECLS-SPCPPLATCNNTQGSFTCRCPVGYQ 1085
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYT 33
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 647-1014 1.70e-09

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 62.65  E-value: 1.70e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568996558  647 PSQAQPKQSSMSSDDDEPAQSSTESPVLHTSNLPTYTSTVNMPNTLVLDTGTKPVEDPSDSRVPSTQPSPSqPQPFSSAL 726
Cdd:PHA03247 2556 PPAAPPAAPDRSVPPPRPAPRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDP-PPPSPSPA 2634

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568996558  727 PSTRSPGSTSETTTSSPSPSPISLLVSTLAPYSVSQTTFPHPSSTlvPHRPREPRVTSvqmstaisaiALIPSNQTANPk 806
Cdd:PHA03247 2635 ANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSP--PQRPRRRAARP----------TVGSLTSLADP- 2701

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568996558  807 nqstPQQEKPITEAKSPSLVSPPTDSTKAVTVSLPPGAPWSPALTGFSTGPALPATSTSLAqmSPALTSAMPQTT--HSP 884
Cdd:PHA03247 2702 ----PPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPA--RPPTTAGPPAPAppAAP 2775

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568996558  885 VTSPSTLSHVEALTSGAVVVHTTPKKPHLPTNPEILVPHISTEGAITTEGNREHTDPTTQPIPLTTSTTSAGERTTELGR 964
Cdd:PHA03247 2776 AAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGS 2855

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|
gi 568996558  965 AEESSPSHFLTPSSPQTTDVSTAEMLTSRYITFAAQSTSQSPTALPPLTP 1014
Cdd:PHA03247 2856 VAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQP 2905
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1015-1051 1.54e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.71  E-value: 1.54e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 568996558 1015 VNSC-TVNPCLHDGKCIvDLTGrGYRCVCPPAWQGENC 1051
Cdd:cd00054     2 IDECaSGNPCQNGGTCV-NTVG-SYRCSCPPGYTGRNC 37
 
Name Accession Description Interval E-value
EGF_CA smart00179
Calcium-binding EGF-like domain;
1054-1085 1.31e-10

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 57.26  E-value: 1.31e-10
                            10        20        30
                    ....*....|....*....|....*....|...
gi 568996558   1054 DVNECLS-SPCPPLATCNNTQGSFTCRCPVGYQ 1085
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1054-1086 1.24e-09

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 54.57  E-value: 1.24e-09
                          10        20        30
                  ....*....|....*....|....*....|....
gi 568996558 1054 DVNECLS-SPCPPLATCNNTQGSFTCRCPVGYQL 1086
Cdd:cd00054     1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTG 34
PHA03247 PHA03247
large tegument protein UL36; Provisional
 647-1014 1.70e-09

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 62.65  E-value: 1.70e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568996558  647 PSQAQPKQSSMSSDDDEPAQSSTESPVLHTSNLPTYTSTVNMPNTLVLDTGTKPVEDPSDSRVPSTQPSPSqPQPFSSAL 726
Cdd:PHA03247 2556 PPAAPPAAPDRSVPPPRPAPRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDP-PPPSPSPA 2634

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568996558  727 PSTRSPGSTSETTTSSPSPSPISLLVSTLAPYSVSQTTFPHPSSTlvPHRPREPRVTSvqmstaisaiALIPSNQTANPk 806
Cdd:PHA03247 2635 ANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSP--PQRPRRRAARP----------TVGSLTSLADP- 2701

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568996558  807 nqstPQQEKPITEAKSPSLVSPPTDSTKAVTVSLPPGAPWSPALTGFSTGPALPATSTSLAqmSPALTSAMPQTT--HSP 884
Cdd:PHA03247 2702 ----PPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPA--RPPTTAGPPAPAppAAP 2775

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568996558  885 VTSPSTLSHVEALTSGAVVVHTTPKKPHLPTNPEILVPHISTEGAITTEGNREHTDPTTQPIPLTTSTTSAGERTTELGR 964
Cdd:PHA03247 2776 AAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGS 2855

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|
gi 568996558  965 AEESSPSHFLTPSSPQTTDVSTAEMLTSRYITFAAQSTSQSPTALPPLTP 1014
Cdd:PHA03247 2856 VAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQP 2905
EGF_CA pfam07645
Calcium-binding EGF domain;
1054-1083 1.43e-08

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 51.47  E-value: 1.43e-08
                           10        20        30
                   ....*....|....*....|....*....|..
gi 568996558  1054 DVNECLSSP--CPPLATCNNTQGSFTCRCPVG 1083
Cdd:pfam07645    1 DVDECATGThnCPANTVCVNTIGSFECRCPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1015-1051 1.54e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.71  E-value: 1.54e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 568996558 1015 VNSC-TVNPCLHDGKCIvDLTGrGYRCVCPPAWQGENC 1051
Cdd:cd00054     2 IDECaSGNPCQNGGTCV-NTVG-SYRCSCPPGYTGRNC 37
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1018-1050 8.50e-06

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 43.53  E-value: 8.50e-06
                           10        20        30
                   ....*....|....*....|....*....|...
gi 568996558  1018 CTVNPCLHDGKCIVdlTGRGYRCVCPPAWQGEN 1050
Cdd:pfam00008    1 CAPNPCSNGGTCVD--TPGGYTCICPEGYTGKR 31
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 653-989 3.25e-05

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 48.03  E-value: 3.25e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568996558   653 KQSSMSSDDDEPAQSSTESPVLHTSNLPTYTSTVnmPNTLVLDTGTKPVEDPSDSRVPSTQPSPSQPQPFSSALPSTRSP 732
Cdd:pfam17823   89 EHTPHGTDLSEPATREGAADGAASRALAAAASSS--PSSAAQSLPAAIAALPSEAFSAPRAAACRANASAAPRAAIAAAS 166

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568996558   733 GSTSETTTSSPSPSPISLLVSTLAPYSVSQTTFPHPSSTLVPHRPREPRVTSVQMSTAISAIALIPSNQTANPKNQSTPQ 812
Cdd:pfam17823  167 APHAASPAPRTAASSTTAASSTTAASSAPTTAASSAPATLTPARGISTAATATGHPAAGTALAAVGNSSPAAGTVTAAVG 246

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568996558   813 QEKPITEAKSPSLVSPPTDSTKAVTVSLPPGAPWSPA-------LTGFSTGPALPATSTSLAQMS---PALTSAMPQTTH 882
Cdd:pfam17823  247 TVTPAALATLAAAAGTVASAAGTINMGDPHARRLSPAkhmpsdtMARNPAAPMGAQAQGPIIQVStdqPVHNTAGEPTPS 326

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568996558   883 SPVTSPSTLSHVEALTSGAVVVHTTPKKPHLPTNPEILVPHISTEGAIttegnrEHTDPTTQPIPLTTSTTSAGE---RT 959
Cdd:pfam17823  327 PSNTTLEPNTPKSVASTNLAVVTTTKAQAKEPSASPVPVLHTSMIPEV------EATSPTTQPSPLLPTQGAAGPgilLA 400

                          330       340       350
                   ....*....|....*....|....*....|
gi 568996558   960 TELGRAEESSPSHFLTPSSPQTTDVSTAEM 989
Cdd:pfam17823  401 PEQVATEATAGTASAGPTPRSSGDPKTLAM 430
EGF_CA smart00179
Calcium-binding EGF-like domain;
1015-1051 1.26e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.31  E-value: 1.26e-04
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 568996558   1015 VNSC-TVNPCLHDGKCIvDLTGrGYRCVCPPAWQ-GENC 1051
Cdd:smart00179    2 IDECaSGNPCQNGGTCV-NTVG-SYRCECPPGYTdGRNC 38
 
Name Accession Description Interval E-value
EGF_CA smart00179
Calcium-binding EGF-like domain;
1054-1085 1.31e-10

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 57.26  E-value: 1.31e-10
                            10        20        30
                    ....*....|....*....|....*....|...
gi 568996558   1054 DVNECLS-SPCPPLATCNNTQGSFTCRCPVGYQ 1085
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1054-1086 1.24e-09

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 54.57  E-value: 1.24e-09
                          10        20        30
                  ....*....|....*....|....*....|....
gi 568996558 1054 DVNECLS-SPCPPLATCNNTQGSFTCRCPVGYQL 1086
Cdd:cd00054     1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTG 34
PHA03247 PHA03247
large tegument protein UL36; Provisional
 647-1014 1.70e-09

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 62.65  E-value: 1.70e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568996558  647 PSQAQPKQSSMSSDDDEPAQSSTESPVLHTSNLPTYTSTVNMPNTLVLDTGTKPVEDPSDSRVPSTQPSPSqPQPFSSAL 726
Cdd:PHA03247 2556 PPAAPPAAPDRSVPPPRPAPRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDP-PPPSPSPA 2634

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568996558  727 PSTRSPGSTSETTTSSPSPSPISLLVSTLAPYSVSQTTFPHPSSTlvPHRPREPRVTSvqmstaisaiALIPSNQTANPk 806
Cdd:PHA03247 2635 ANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSP--PQRPRRRAARP----------TVGSLTSLADP- 2701

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568996558  807 nqstPQQEKPITEAKSPSLVSPPTDSTKAVTVSLPPGAPWSPALTGFSTGPALPATSTSLAqmSPALTSAMPQTT--HSP 884
Cdd:PHA03247 2702 ----PPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPA--RPPTTAGPPAPAppAAP 2775

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568996558  885 VTSPSTLSHVEALTSGAVVVHTTPKKPHLPTNPEILVPHISTEGAITTEGNREHTDPTTQPIPLTTSTTSAGERTTELGR 964
Cdd:PHA03247 2776 AAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGS 2855

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|
gi 568996558  965 AEESSPSHFLTPSSPQTTDVSTAEMLTSRYITFAAQSTSQSPTALPPLTP 1014
Cdd:PHA03247 2856 VAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQP 2905
EGF_CA pfam07645
Calcium-binding EGF domain;
1054-1083 1.43e-08

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 51.47  E-value: 1.43e-08
                           10        20        30
                   ....*....|....*....|....*....|..
gi 568996558  1054 DVNECLSSP--CPPLATCNNTQGSFTCRCPVG 1083
Cdd:pfam07645    1 DVDECATGThnCPANTVCVNTIGSFECRCPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1015-1051 1.54e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.71  E-value: 1.54e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 568996558 1015 VNSC-TVNPCLHDGKCIvDLTGrGYRCVCPPAWQGENC 1051
Cdd:cd00054     2 IDECaSGNPCQNGGTCV-NTVG-SYRCSCPPGYTGRNC 37
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 1057-1088 2.13e-06

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 45.55  E-value: 2.13e-06
                          10        20        30
                  ....*....|....*....|....*....|...
gi 568996558 1057 EC-LSSPCPPLATCNNTQGSFTCRCPVGYQLEK 1088
Cdd:cd00053     1 ECaASNPCSNGGTCVNTPGSYRCVCPPGYTGDR 33
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1018-1050 8.50e-06

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 43.53  E-value: 8.50e-06
                           10        20        30
                   ....*....|....*....|....*....|...
gi 568996558  1018 CTVNPCLHDGKCIVdlTGRGYRCVCPPAWQGEN 1050
Cdd:pfam00008    1 CAPNPCSNGGTCVD--TPGGYTCICPEGYTGKR 31
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 1062-1085 1.20e-05

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 43.36  E-value: 1.20e-05
                           10        20
                   ....*....|....*....|....
gi 568996558  1062 PCPPLATCNNTQGSFTCRCPVGYQ 1085
Cdd:pfam12947    7 GCHPNATCTNTGGSFTCTCNDGYT 30
PHA03247 PHA03247
large tegument protein UL36; Provisional
 660-992 2.25e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 49.17  E-value: 2.25e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568996558  660 DDDEPAQSSTESP--VLHTSNLPTYTSTVNMPNTLVLDTGTKPVEDPSDSRVPSTQPSPSqPQPFSSALP------STRS 731
Cdd:PHA03247 2652 PRDDPAPGRVSRPrrARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPA-PHALVSATPlppgpaAARQ 2730

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568996558  732 PGSTSETTTSSPSPSPISLLVSTLAPYSVSQTTF--PHPSSTLVPHRPREPRVTSVQMSTAISAIALIPSNQTANPKNQS 809
Cdd:PHA03247 2731 ASPALPAAPAPPAVPAGPATPGGPARPARPPTTAgpPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAA 2810

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568996558  810 TPQQEKPITEAKSPSLVSPPTDSTKAVTVSLPPGAPWSPALTGFSTGPALPATSTSLAQMSPAL--TSAMPQTTHSPVTS 887
Cdd:PHA03247 2811 VLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKpaAPARPPVRRLARPA 2890

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568996558  888 PSTLSHVEALTSGAVVVHTTPKKPHLPTNPEILVPHISTEGAITTEGnREHTDPTTQPIPLTTSTTSAGERTTELG---- 963
Cdd:PHA03247 2891 VSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPP-RPQPPLAPTTDPAGAGEPSGAVPQPWLGalvp 2969

                         330       340       350
                  ....*....|....*....|....*....|....*..
gi 568996558  964 --------RAEESSPSHFLTPSSPQTTDVSTAEMLTS 992
Cdd:PHA03247 2970 grvavprfRVPQPAPSREAPASSTPPLTGHSLSRVSS 3006
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 653-989 3.25e-05

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 48.03  E-value: 3.25e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568996558   653 KQSSMSSDDDEPAQSSTESPVLHTSNLPTYTSTVnmPNTLVLDTGTKPVEDPSDSRVPSTQPSPSQPQPFSSALPSTRSP 732
Cdd:pfam17823   89 EHTPHGTDLSEPATREGAADGAASRALAAAASSS--PSSAAQSLPAAIAALPSEAFSAPRAAACRANASAAPRAAIAAAS 166

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568996558   733 GSTSETTTSSPSPSPISLLVSTLAPYSVSQTTFPHPSSTLVPHRPREPRVTSVQMSTAISAIALIPSNQTANPKNQSTPQ 812
Cdd:pfam17823  167 APHAASPAPRTAASSTTAASSTTAASSAPTTAASSAPATLTPARGISTAATATGHPAAGTALAAVGNSSPAAGTVTAAVG 246

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568996558   813 QEKPITEAKSPSLVSPPTDSTKAVTVSLPPGAPWSPA-------LTGFSTGPALPATSTSLAQMS---PALTSAMPQTTH 882
Cdd:pfam17823  247 TVTPAALATLAAAAGTVASAAGTINMGDPHARRLSPAkhmpsdtMARNPAAPMGAQAQGPIIQVStdqPVHNTAGEPTPS 326

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568996558   883 SPVTSPSTLSHVEALTSGAVVVHTTPKKPHLPTNPEILVPHISTEGAIttegnrEHTDPTTQPIPLTTSTTSAGE---RT 959
Cdd:pfam17823  327 PSNTTLEPNTPKSVASTNLAVVTTTKAQAKEPSASPVPVLHTSMIPEV------EATSPTTQPSPLLPTQGAAGPgilLA 400

                          330       340       350
                   ....*....|....*....|....*....|
gi 568996558   960 TELGRAEESSPSHFLTPSSPQTTDVSTAEM 989
Cdd:pfam17823  401 PEQVATEATAGTASAGPTPRSSGDPKTLAM 430
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 758-1008 6.22e-05

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 47.60  E-value: 6.22e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568996558   758 YSVSQTTFPHPSSTLVPHRPREPRVTSVQMSTA-ISAIALIPSNQTANPKNQStPQQEKPITEAKSPSLVSP-------- 828
Cdd:pfam05109  439 FAAPNTTTGLPSSTHVPTNLTAPASTGPTVSTAdVTSPTPAGTTSGASPVTPS-PSPRDNGTESKAPDMTSPtsavttpt 517

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568996558   829 PTDSTKAVTVSLPPGAPWSPALTGFSTGPALPATSTSLAQMSPALTSAMPQTTHSPVTSPSTLSHVEALTSGAVVVHTTP 908
Cdd:pfam05109  518 PNATSPTPAVTTPTPNATSPTLGKTSPTSAVTTPTPNATSPTPAVTTPTPNATIPTLGKTSPTSAVTTPTPNATSPTVGE 597

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568996558   909 KKPHLPTNPEILVPHISTEGAITTEGNREHTDPTTQPIPLTTSTTSAGERttelgraeessPSHFLTPSSPQTTDVSTAE 988
Cdd:pfam05109  598 TSPQANTTNHTLGGTSSTPVVTSPPKNATSAVTTGQHNITSSSTSSMSLR-----------PSSISETLSPSTSDNSTSH 666

                          250       260
                   ....*....|....*....|..
gi 568996558   989 M--LTSRYITFAAQSTSQSPTA 1008
Cdd:pfam05109  667 MplLTSAHPTGGENITQVTPAS 688
EGF_CA smart00179
Calcium-binding EGF-like domain;
1015-1051 1.26e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.31  E-value: 1.26e-04
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 568996558   1015 VNSC-TVNPCLHDGKCIvDLTGrGYRCVCPPAWQ-GENC 1051
Cdd:smart00179    2 IDECaSGNPCQNGGTCV-NTVG-SYRCECPPGYTdGRNC 38
EGF smart00181
Epidermal growth factor-like domain;
1057-1088 1.59e-04

Epidermal growth factor-like domain;


Pssm-ID: 214544  Cd Length: 35  Bit Score: 40.19  E-value: 1.59e-04
                            10        20        30
                    ....*....|....*....|....*....|...
gi 568996558   1057 ECLS-SPCPPlATCNNTQGSFTCRCPVGYQLEK 1088
Cdd:smart00181    1 ECASgGPCSN-GTCINTPGSYTCSCPPGYTGDK 32
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 1021-1051 5.01e-04

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 38.61  E-value: 5.01e-04
                          10        20        30
                  ....*....|....*....|....*....|..
gi 568996558 1021 NPCLHDGKCIVdlTGRGYRCVCPPAWQGE-NC 1051
Cdd:cd00053     6 NPCSNGGTCVN--TPGSYRCVCPPGYTGDrSC 35
EB pfam01683
EB module; This domain has no known function. It is found in several C. elegans proteins. The ...
 1018-1091 5.27e-04

EB module; This domain has no known function. It is found in several C. elegans proteins. The domain contains 8 conserved cysteines that probably form four disulphide bridges. This domain is found associated with kunitz domains pfam00014.


Pssm-ID: 460294  Cd Length: 52  Bit Score: 39.33  E-value: 5.27e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568996558  1018 CTVNPCLHDGKCIvdltgrgyrcvcPPAWQGENCSVDVNeclsspCPPLATCNNTqgsfTCRCPVGYQLEKGIC 1091
Cdd:pfam01683    1 CPPGQVLVNGQCV------------PKVAPGESCEADEQ------CPGGSVCVNG----VCQCPPGFTPVNGRC 52
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1058-1084 5.73e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 38.52  E-value: 5.73e-04
                           10        20
                   ....*....|....*....|....*..
gi 568996558  1058 CLSSPCPPLATCNNTQGSFTCRCPVGY 1084
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGY 27
PLN03209 PLN03209
translocon at the inner envelope of chloroplast subunit 62; Provisional
 707-952 4.29e-03

translocon at the inner envelope of chloroplast subunit 62; Provisional


Pssm-ID: 178748 [Multi-domain]  Cd Length: 576  Bit Score: 41.45  E-value: 4.29e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568996558  707 SRVPSTQPSPSQPQPFS--SALPSTRSPGSTSETTTSSPSPSPISLLVSTLAPYSVSQTTFPHPSSTLVPHRPREPRVTS 784
Cdd:PLN03209  321 AKIPSQRVPPKESDAADgpKPVPTKPVTPEAPSPPIEEEPPQPKAVVPRPLSPYTAYEDLKPPTSPIPTPPSSSPASSKS 400

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568996558  785 VQMSTAISAIALIPSNQTANPKNQSTP-----QQEKPIT------EAKSPSLVSPPTDSTKAVTVSLPPGAPWSPaltgf 853
Cdd:PLN03209  401 VDAVAKPAEPDVVPSPGSASNVPEVEPaqveaKKTRPLSpyaryeDLKPPTSPSPTAPTGVSPSVSSTSSVPAVP----- 475

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568996558  854 STGPALPATSTSL---AQMSPaLTSAMPQTTHSPVTSPSTLShvealtsgavvvhTTPKKPHLPTNPEILVPHISTEGAI 930
Cdd:PLN03209  476 DTAPATAATDAAApppANMRP-LSPYAVYDDLKPPTSPSPAA-------------PVGKVAPSSTNEVVKVGNSAPPTAL 541

                         250       260
                  ....*....|....*....|..
gi 568996558  931 TTEGNreHTDPttQPIPLTTST 952
Cdd:PLN03209  542 ADEQH--HAQP--KPRPLSPYT 559
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH