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Conserved domains on  [gi|568998477|ref|XP_006523467|]
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intraflagellar transport protein 140 homolog isoform X2 [Mus musculus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455411)

WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; contains tetratricopeptide repeats

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 835-1037 4.11e-10

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 62.44  E-value: 4.11e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568998477  835 RALREAEQEPELEARVAMLAIQLGMLEEAEQLYKKCKRYD--------LLNKFYQASDQWQKAVEVAE--LHDRVHLRTT 904
Cdd:COG2956    67 KLLERDPDRAEALLELAQDYLKAGLLDRAEELLEKLLELDpddaealrLLAEIYEQEGDWEKAIEVLErlLKLGPENAHA 146

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568998477  905 YYNYAKHLEASADCGQALSYYEKsdthrfevprMLSEDLQSLELYINRmkdktlwrwwAQYLESQAEMDTALRYYE--LA 982
Cdd:COG2956   147 YCELAELYLEQGDYDEAIEALEK----------ALKLDPDCARALLLL----------AELYLEQGDYEEAIAALEraLE 206

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568998477  983 QD------YFSLVRIHCFQGNIQKAAE----IANETGDWAASYHLARQYESQDEVKQAVHFYTRA 1037
Cdd:COG2956   207 QDpdylpaLPRLAELYEKLGDPEEALEllrkALELDPSDDLLLALADLLERKEGLEAALALLERQ 271
WD40 super family cl43672
WD40 repeat [General function prediction only];
24-133 8.36e-05

WD40 repeat [General function prediction only];


The actual alignment was detected with superfamily member COG2319:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 46.83  E-value: 8.36e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568998477   24 HPTHPFLAVAsISP--------SSGGNVDIY-LEQGEPVPdTHIERSFQATSLCWHPTRLILAIGWETGEVIMFNKQDKE 94
Cdd:COG2319   286 GHSGGVNSVA-FSPdgkllasgSDDGTVRLWdLATGKLLR-TLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGE 363

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 568998477   95 QHTVPLPHTTDIAILSWSTSGSCLVSGDKLGVLLLWRLD 133
Cdd:COG2319   364 LLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 783-874 5.27e-03

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


:

Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 38.63  E-value: 5.27e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568998477  783 FVTIGDMDEAF----KSIKLIKSEA-VWENMARMCVKTQRLDVAKVCLgnmghargARALREAEQEPELEARVAMLAIQL 857
Cdd:COG4783    48 LLQLGDLDEAIvllhEALELDPDEPeARLNLGLALLKAGDYDEALALL--------EKALKLDPEHPEAYLRLARAYRAL 119

                          90
                  ....*....|....*..
gi 568998477  858 GMLEEAEQLYKKCKRYD 874
Cdd:COG4783   120 GRPDEAIAALEKALELD 136
 
Name Accession Description Interval E-value
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 835-1037 4.11e-10

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 62.44  E-value: 4.11e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568998477  835 RALREAEQEPELEARVAMLAIQLGMLEEAEQLYKKCKRYD--------LLNKFYQASDQWQKAVEVAE--LHDRVHLRTT 904
Cdd:COG2956    67 KLLERDPDRAEALLELAQDYLKAGLLDRAEELLEKLLELDpddaealrLLAEIYEQEGDWEKAIEVLErlLKLGPENAHA 146

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568998477  905 YYNYAKHLEASADCGQALSYYEKsdthrfevprMLSEDLQSLELYINRmkdktlwrwwAQYLESQAEMDTALRYYE--LA 982
Cdd:COG2956   147 YCELAELYLEQGDYDEAIEALEK----------ALKLDPDCARALLLL----------AELYLEQGDYEEAIAALEraLE 206

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568998477  983 QD------YFSLVRIHCFQGNIQKAAE----IANETGDWAASYHLARQYESQDEVKQAVHFYTRA 1037
Cdd:COG2956   207 QDpdylpaLPRLAELYEKLGDPEEALEllrkALELDPSDDLLLALADLLERKEGLEAALALLERQ 271
WD40 COG2319
WD40 repeat [General function prediction only];
24-133 8.36e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 46.83  E-value: 8.36e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568998477   24 HPTHPFLAVAsISP--------SSGGNVDIY-LEQGEPVPdTHIERSFQATSLCWHPTRLILAIGWETGEVIMFNKQDKE 94
Cdd:COG2319   286 GHSGGVNSVA-FSPdgkllasgSDDGTVRLWdLATGKLLR-TLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGE 363

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 568998477   95 QHTVPLPHTTDIAILSWSTSGSCLVSGDKLGVLLLWRLD 133
Cdd:COG2319   364 LLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 19-139 1.53e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 42.32  E-value: 1.53e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568998477   19 SHITWHPTHPFLAVASISpssgGNVDIY-LEQGEPVpDTHIERSFQATSLCWHPTRLILAIGWETGEVIMFNKQDKEQHT 97
Cdd:cd00200   139 NSVAFSPDGTFVASSSQD----GTIKLWdLRTGKCV-ATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLG 213

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 568998477   98 VPLPHTTDIAILSWSTSGSCLVSGDKLGVLLLWRLDQRGRVQ 139
Cdd:cd00200   214 TLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQ 255
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 783-874 5.27e-03

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 38.63  E-value: 5.27e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568998477  783 FVTIGDMDEAF----KSIKLIKSEA-VWENMARMCVKTQRLDVAKVCLgnmghargARALREAEQEPELEARVAMLAIQL 857
Cdd:COG4783    48 LLQLGDLDEAIvllhEALELDPDEPeARLNLGLALLKAGDYDEALALL--------EKALKLDPEHPEAYLRLARAYRAL 119

                          90
                  ....*....|....*..
gi 568998477  858 GMLEEAEQLYKKCKRYD 874
Cdd:COG4783   120 GRPDEAIAALEKALELD 136
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 64-112 6.09e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 37.26  E-value: 6.09e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 568998477    64 ATSLCWHPTRLILAIGWETGEVIMFNKQD-KEQHTVPlPHTTDIAILSWS 112
Cdd:pfam12894   41 VTSLAWRPDGKLLAVGYSDGTVRLLDAENgKIVHHFS-AGSDLITCLGWG 89
 
Name Accession Description Interval E-value
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 835-1037 4.11e-10

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 62.44  E-value: 4.11e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568998477  835 RALREAEQEPELEARVAMLAIQLGMLEEAEQLYKKCKRYD--------LLNKFYQASDQWQKAVEVAE--LHDRVHLRTT 904
Cdd:COG2956    67 KLLERDPDRAEALLELAQDYLKAGLLDRAEELLEKLLELDpddaealrLLAEIYEQEGDWEKAIEVLErlLKLGPENAHA 146

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568998477  905 YYNYAKHLEASADCGQALSYYEKsdthrfevprMLSEDLQSLELYINRmkdktlwrwwAQYLESQAEMDTALRYYE--LA 982
Cdd:COG2956   147 YCELAELYLEQGDYDEAIEALEK----------ALKLDPDCARALLLL----------AELYLEQGDYEEAIAALEraLE 206

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568998477  983 QD------YFSLVRIHCFQGNIQKAAE----IANETGDWAASYHLARQYESQDEVKQAVHFYTRA 1037
Cdd:COG2956   207 QDpdylpaLPRLAELYEKLGDPEEALEllrkALELDPSDDLLLALADLLERKEGLEAALALLERQ 271
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 851-1150 6.62e-10

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 61.67  E-value: 6.62e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568998477  851 AMLAIQLGMLEEAEQLYKKcKRYDllnkfyQASDQWQKAVEVAELHDRVHLrttyyNYAKHLEASADCGQALSYYEKsdt 930
Cdd:COG2956     3 LPVAAALGWYFKGLNYLLN-GQPD------KAIDLLEEALELDPETVEAHL-----ALGNLYRRRGEYDRAIRIHQK--- 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568998477  931 hrfevprMLSEDLQSLELYINRmkdktlwrwwAQYLESQAEMDTALRYYELAQD--------YFSLVRIHCFQGNIQKAA 1002
Cdd:COG2956    68 -------LLERDPDRAEALLEL----------AQDYLKAGLLDRAEELLEKLLEldpddaeaLRLLAEIYEQEGDWEKAI 130

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568998477 1003 EIANE-----TGDWAASYHLARQYESQDEVKQAVHFYTRAQAFN-NAIRLckenglddqLMNLA-LLSSPEDMIEAARYY 1075
Cdd:COG2956   131 EVLERllklgPENAHAYCELAELYLEQGDYDEAIEALEKALKLDpDCARA---------LLLLAeLYLEQGDYEEAIAAL 201

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568998477 1076 EEKGEQMDRAVMLYHKAGHFSKALElafttQQFAALQLIAEDLDEKSDPALLARCSDFCIEHRQFEKAVELLLAA 1150
Cdd:COG2956   202 ERALEQDPDYLPALPRLAELYEKLG-----DPEEALELLRKALELDPSDDLLLALADLLERKEGLEAALALLERQ 271
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 835-1078 3.76e-07

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 53.19  E-value: 3.76e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568998477  835 RALREAEQEPELEARVAMLAIQLGMLEEAEQLYKKCKRYD--------LLNKFYQASDQWQKAVEVAE--LHDRVHLRTT 904
Cdd:COG2956    33 EALELDPETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDpdraeallELAQDYLKAGLLDRAEELLEklLELDPDDAEA 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568998477  905 YYNYAKHLEASADCGQALSYYEksdthrfevpRMLSEDLQSLELYINRmkdktlwrwwAQYLESQAEMDTALRYYE--LA 982
Cdd:COG2956   113 LRLLAEIYEQEGDWEKAIEVLE----------RLLKLGPENAHAYCEL----------AELYLEQGDYDEAIEALEkaLK 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568998477  983 QD------YFSLVRIHCFQGNIQKAAE-----IANETGDWAASYHLARQYESQDEVKQAVHFYTRAQAfnnairlckENG 1051
Cdd:COG2956   173 LDpdcaraLLLLAELYLEQGDYEEAIAaleraLEQDPDYLPALPRLAELYEKLGDPEEALELLRKALE---------LDP 243

                         250       260
                  ....*....|....*....|....*..
gi 568998477 1052 LDDQLMNLALLSSPEDMIEAARYYEEK 1078
Cdd:COG2956   244 SDDLLLALADLLERKEGLEAALALLER 270
WD40 COG2319
WD40 repeat [General function prediction only];
24-133 8.36e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 46.83  E-value: 8.36e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568998477   24 HPTHPFLAVAsISP--------SSGGNVDIY-LEQGEPVPdTHIERSFQATSLCWHPTRLILAIGWETGEVIMFNKQDKE 94
Cdd:COG2319   286 GHSGGVNSVA-FSPdgkllasgSDDGTVRLWdLATGKLLR-TLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGE 363

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 568998477   95 QHTVPLPHTTDIAILSWSTSGSCLVSGDKLGVLLLWRLD 133
Cdd:COG2319   364 LLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 786-894 9.52e-05

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 43.64  E-value: 9.52e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568998477  786 IGDMDEAFKSI-KLIKSE----AVWENMARMCVKTQRLDVAKVCLgnmghargARALREAEQEPELEARVAMLAIQLGML 860
Cdd:COG4783    17 AGDYDEAEALLeKALELDpdnpEAFALLGEILLQLGDLDEAIVLL--------HEALELDPDEPEARLNLGLALLKAGDY 88

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 568998477  861 EEAEQLYKKCKR--------YDLLNKFYQASDQWQKAVEVAE 894
Cdd:COG4783    89 DEALALLEKALKldpehpeaYLRLARAYRALGRPDEAIAALE 130
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 830-1073 1.65e-04

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 46.14  E-value: 1.65e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568998477  830 HARGARALREAEQEPELEARVAMLAIQLgmLEEAEQLYKKCKRYDllnkfyQASDQWQKAVEVAELHDRVHlrttyYNYA 909
Cdd:COG3914    53 EAAAAALLALAAGEAAAAAAALLLLAAL--LELAALLLQALGRYE------EALALYRRALALNPDNAEAL-----FNLG 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568998477  910 KHLEASADCGQALSYYEKSdthrfevprmLSEDLQSLELYINRmkdktlwrwwAQYLESQAEMDTALRYYE--LAQD--- 984
Cdd:COG3914   120 NLLLALGRLEEALAALRRA----------LALNPDFAEAYLNL----------GEALRRLGRLEEAIAALRraLELDpdn 179

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568998477  985 ---YFSLVRIHCFQGNIQKAAEIANE------TGDWAASYHLARQYESQDevkqavhfYTRAQAFNNAIRLCKENGldDQ 1055
Cdd:COG3914   180 aeaLNNLGNALQDLGRLEEAIAAYRRaleldpDNADAHSNLLFALRQACD--------WEVYDRFEELLAALARGP--SE 249

                         250       260
                  ....*....|....*....|..
gi 568998477 1056 LMNLALLS----SPEDMIEAAR 1073
Cdd:COG3914   250 LSPFALLYlpddDPAELLALAR 271
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 19-139 1.53e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 42.32  E-value: 1.53e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568998477   19 SHITWHPTHPFLAVASISpssgGNVDIY-LEQGEPVpDTHIERSFQATSLCWHPTRLILAIGWETGEVIMFNKQDKEQHT 97
Cdd:cd00200   139 NSVAFSPDGTFVASSSQD----GTIKLWdLRTGKCV-ATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLG 213

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 568998477   98 VPLPHTTDIAILSWSTSGSCLVSGDKLGVLLLWRLDQRGRVQ 139
Cdd:cd00200   214 TLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQ 255
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
804-1044 1.58e-03

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 41.92  E-value: 1.58e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568998477  804 VWENMARMCVKTQRLDVAKVCLgnmghargARALREAEQEPELEARVAMLAIQLGMLEEAEQLYKKCKRYD------LLN 877
Cdd:COG0457    10 AYNNLGLAYRRLGRYEEAIEDY--------EKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDpddaeaLNN 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568998477  878 K--FYQASDQWQKAVEVAE--LHDRVHLRTTYYNYAKHLEASADCGQALSYYEKSdthrfevprmLSEDLQSLELYINRm 953
Cdd:COG0457    82 LglALQALGRYEEALEDYDkaLELDPDDAEALYNLGLALLELGRYDEAIEAYERA----------LELDPDDADALYNL- 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568998477  954 kdktlwrwwAQYLESQAEMDTALRYYELAQDYFSLVRIHCFQGNIQKAAEIANETGDWAASYHLARQYESQDEVKQAVHF 1033
Cdd:COG0457   151 ---------GIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQALRKKLAILTLAALAE 221

                         250
                  ....*....|.
gi 568998477 1034 YTRAQAFNNAI 1044
Cdd:COG0457   222 LLLLALALLLA 232
WD40 COG2319
WD40 repeat [General function prediction only];
16-139 2.17e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 42.21  E-value: 2.17e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568998477   16 SSPSHITWHPTHPFLAVASispsSGGNVDIY-LEQGEPVpDTHIERSFQATSLCWHPTRLILAIGWETGEVIMFNKQDKE 94
Cdd:COG2319   247 GSVRSVAFSPDGRLLASGS----ADGTVRLWdLATGELL-RTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGK 321

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 568998477   95 QHTVPLPHTTDIAILSWSTSGSCLVSGDKLGVLLLWRLDQRGRVQ 139
Cdd:COG2319   322 LLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLR 366
WD40 COG2319
WD40 repeat [General function prediction only];
19-140 4.49e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 41.05  E-value: 4.49e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568998477   19 SHITWHPTHPFLAVASispsSGGNVDIY-LEQGEPVpDTHIERSFQATSLCWHPTRLILAIGWETGEVIMFNKQDKEQHT 97
Cdd:COG2319   208 RSVAFSPDGKLLASGS----ADGTVRLWdLATGKLL-RTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLR 282

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 568998477   98 VPLPHTTDIAILSWSTSGSCLVSGDKLGVLLLWRLDQRGRVQG 140
Cdd:COG2319   283 TLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRT 325
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 783-874 5.27e-03

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 38.63  E-value: 5.27e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568998477  783 FVTIGDMDEAF----KSIKLIKSEA-VWENMARMCVKTQRLDVAKVCLgnmghargARALREAEQEPELEARVAMLAIQL 857
Cdd:COG4783    48 LLQLGDLDEAIvllhEALELDPDEPeARLNLGLALLKAGDYDEALALL--------EKALKLDPEHPEAYLRLARAYRAL 119

                          90
                  ....*....|....*..
gi 568998477  858 GMLEEAEQLYKKCKRYD 874
Cdd:COG4783   120 GRPDEAIAALEKALELD 136
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 64-112 6.09e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 37.26  E-value: 6.09e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 568998477    64 ATSLCWHPTRLILAIGWETGEVIMFNKQD-KEQHTVPlPHTTDIAILSWS 112
Cdd:pfam12894   41 VTSLAWRPDGKLLAVGYSDGTVRLLDAENgKIVHHFS-AGSDLITCLGWG 89
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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