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Conserved domains on  [gi|569001319|ref|XP_006524837|]
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high affinity choline transporter 1 isoform X1 [Mus musculus]

Protein Classification

sodium:solute symporter family protein( domain architecture ID 10183701)

sodium:solute symporter family protein similar to human high-affinity choline transporter 1 (CHT), also called solute carrier family 5 member 7, which is a sodium ion- and chloride ion-dependent transmembrane transporter that imports choline from the extracellular space into the neuron

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
SLC5sbd_CHT cd11474
Na(+)- and Cl(-)-dependent choline cotransporter CHT and related proteins; solute-binding ...
8-495 0e+00

Na(+)- and Cl(-)-dependent choline cotransporter CHT and related proteins; solute-binding domain; Na+/choline co-transport by CHT is Cl- dependent. Human CHT (also called CHT1) is encoded by the SLC5A7 gene, and is expressed in the central nervous system. hCHT1-mediated choline uptake may be the rate-limiting step in acetylcholine synthesis, and essential for cholinergic transmission. Changes in this choline uptake in cortical neurons may contribute to Alzheimer's dementia. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.


:

Pssm-ID: 271368 [Multi-domain]  Cd Length: 464  Bit Score: 582.95  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319   8 LVAIILFYLLIFLVGIWAAWKTKNSGNpeerseaIIVGGRDIGLLVGGFTMTATWVGGGYINGTAEAVYGPGCGLAwAQA 87
Cdd:cd11474    1 LIGVILYYLLILGIGLWASRRVKSSED-------FLLAGRSLPLPVGVFTLFATWFGGETILGAAETFYEEGLGGV-AQD 72
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319  88 PIGYSLSLILGGLFFAKPMRSKGYVTMLDPFQQIYGKRMGGLLFIPALMGEMFWAAAIFSALGATISVIIDVDVNISVIV 167
Cdd:cd11474   73 PFGYALCLILGGLFFAKPMRRMGLLTLGDFFRQRYGRRVEVLLSIPAVLSYLGWVAAQLVALGLVLSVILGLPVETGILI 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319 168 SALIAILYTLVGGLYSVAYTDVVQLFCIFIGLWISVPFALSHPAVTDIG-FTAVHAKYQSPWLGTIEsvEVYTWLDNFLL 246
Cdd:cd11474  153 SAAIVLAYTLFGGMWSVAYTDVVQLIVIFVGLLVLVPFVLTNPGGVDIAsAAAAGKLRFFPWLGTKS--DWLIWIDAWLT 230
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319 247 LMLGGIPWQAYFQRVLSSSSATYAQVLSFLAAFGCLVMALPAICIGAIGASTDWNQTAYGypdpkTKEEADMILPIVLQY 326
Cdd:cd11474  231 LGLGSIPQQDVFQRVLSAKSEKTAQRLSLLAGVGYLLFAIPPLLIGLAAASIDPSLTQYG-----LEEDAQLILPLLLQY 305
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319 327 LCPVYISFFGLGAVSAAVMSSADSSILSASSMFARNIYQLSFRQNASDKEIVWVMRITVLVFGASATAMALLTKTVYGLW 406
Cdd:cd11474  306 LTPLWVQVLFLGALLSAVMSTADSALLAPSSVFSENIYKPPFRPKASDRELLWVMRISVVVFGAIATLMALTVESIYGLV 385
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319 407 YLSSDLVYIIIFPQLLCVLFIKGTNTYGAVAGYIFGLFLRITGGEPYLYLQPLIfypgyysdknGIYNQRFPFKTLSMVT 486
Cdd:cd11474  386 ELASDLVLVGLFVPLLAGLYWKRANTYGALAAIIVGLVLRLLGGELLLGLPADI----------PPQLQGFPFSTLAMVI 455

                 ....*....
gi 569001319 487 SFFTNICVS 495
Cdd:cd11474  456 GSLLPLAVS 464
 
Name Accession Description Interval E-value
SLC5sbd_CHT cd11474
Na(+)- and Cl(-)-dependent choline cotransporter CHT and related proteins; solute-binding ...
8-495 0e+00

Na(+)- and Cl(-)-dependent choline cotransporter CHT and related proteins; solute-binding domain; Na+/choline co-transport by CHT is Cl- dependent. Human CHT (also called CHT1) is encoded by the SLC5A7 gene, and is expressed in the central nervous system. hCHT1-mediated choline uptake may be the rate-limiting step in acetylcholine synthesis, and essential for cholinergic transmission. Changes in this choline uptake in cortical neurons may contribute to Alzheimer's dementia. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271368 [Multi-domain]  Cd Length: 464  Bit Score: 582.95  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319   8 LVAIILFYLLIFLVGIWAAWKTKNSGNpeerseaIIVGGRDIGLLVGGFTMTATWVGGGYINGTAEAVYGPGCGLAwAQA 87
Cdd:cd11474    1 LIGVILYYLLILGIGLWASRRVKSSED-------FLLAGRSLPLPVGVFTLFATWFGGETILGAAETFYEEGLGGV-AQD 72
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319  88 PIGYSLSLILGGLFFAKPMRSKGYVTMLDPFQQIYGKRMGGLLFIPALMGEMFWAAAIFSALGATISVIIDVDVNISVIV 167
Cdd:cd11474   73 PFGYALCLILGGLFFAKPMRRMGLLTLGDFFRQRYGRRVEVLLSIPAVLSYLGWVAAQLVALGLVLSVILGLPVETGILI 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319 168 SALIAILYTLVGGLYSVAYTDVVQLFCIFIGLWISVPFALSHPAVTDIG-FTAVHAKYQSPWLGTIEsvEVYTWLDNFLL 246
Cdd:cd11474  153 SAAIVLAYTLFGGMWSVAYTDVVQLIVIFVGLLVLVPFVLTNPGGVDIAsAAAAGKLRFFPWLGTKS--DWLIWIDAWLT 230
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319 247 LMLGGIPWQAYFQRVLSSSSATYAQVLSFLAAFGCLVMALPAICIGAIGASTDWNQTAYGypdpkTKEEADMILPIVLQY 326
Cdd:cd11474  231 LGLGSIPQQDVFQRVLSAKSEKTAQRLSLLAGVGYLLFAIPPLLIGLAAASIDPSLTQYG-----LEEDAQLILPLLLQY 305
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319 327 LCPVYISFFGLGAVSAAVMSSADSSILSASSMFARNIYQLSFRQNASDKEIVWVMRITVLVFGASATAMALLTKTVYGLW 406
Cdd:cd11474  306 LTPLWVQVLFLGALLSAVMSTADSALLAPSSVFSENIYKPPFRPKASDRELLWVMRISVVVFGAIATLMALTVESIYGLV 385
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319 407 YLSSDLVYIIIFPQLLCVLFIKGTNTYGAVAGYIFGLFLRITGGEPYLYLQPLIfypgyysdknGIYNQRFPFKTLSMVT 486
Cdd:cd11474  386 ELASDLVLVGLFVPLLAGLYWKRANTYGALAAIIVGLVLRLLGGELLLGLPADI----------PPQLQGFPFSTLAMVI 455

                 ....*....
gi 569001319 487 SFFTNICVS 495
Cdd:cd11474  456 GSLLPLAVS 464
PutP COG0591
Na+/proline symporter [Amino acid transport and metabolism];
8-447 4.30e-78

Na+/proline symporter [Amino acid transport and metabolism];


Pssm-ID: 440356 [Multi-domain]  Cd Length: 476  Bit Score: 254.36  E-value: 4.30e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319   8 LVAIILFYLLIFLVGIWAAWKTKNSgnpeersEAIIVGGRDIGLLVGGFTMTATWVGGGYINGTAEAVYGpgCGLAWAQA 87
Cdd:COG0591    6 LIIIILYLLLLLGIGLYASRRTKSL-------EDYFLAGRSLGWWVLALSLGATWLSAWTFLGVPGLAYA--YGLSALWY 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319  88 PIGYSLSLILGGLFFAKPMRSKGYVTMLDPFQQIYGKRMGGLLFIPALMGEMFWAAAIFSALGATISVIIDVDVNISVIV 167
Cdd:COG0591   77 ALGYALGALLLALFFAPRLRRLGALTIPEFLEKRFGRGLRLLAAIIILLFLLGYLAAQLVALGKLLEALFGIPYWLGILI 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319 168 SALIAILYTLVGGLYSVAYTDVVQLFCIFIGLWISVPFALSHPAvtdiGFTAVHAKYQSP----WLGTIESVEVYTWLDN 243
Cdd:COG0591  157 GALIVLLYTVLGGLRAVAWTDVLQGILMLVGLILLLIVALSALG----GFGELFAALPAPgllsLFPGLGFTGWLAFLGL 232
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319 244 FLLLMLGGIPWQAYFQRVLSSSSATYAQVLSFLAAFGCLVMALPAICIGAIgastdwnqtAYGYPDPKTKEEADMILPIV 323
Cdd:COG0591  233 FLAIGLGYFGQPHIVQRFLAAKSEKEARKAALIGGLLYLLFYLLAALIGLL---------ARALFPDLPLADPDLALPLL 303
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319 324 LQYLCPVYISFFGLGAVSAAVMSSADSSILSASSMFARNIYQLSFRQNASDKEIVWVMRITVLVFGASATAMALLTK-TV 402
Cdd:COG0591  304 ILELLPPGLAGLLLAAILAAAMSTADSQLLAASSVFTRDIYKPFIKPKASDKQLLRVSRLAVLVVGLLALLLALLFPsSI 383
                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*
gi 569001319 403 YGLWYLSSDLVYIIIFPQLLCVLFIKGTNTYGAVAGYIFGLFLRI 447
Cdd:COG0591  384 LDLVLLAWGGLGAALLPPLLLGLFWKRATKAGALAGMIAGLVVVL 428
sss TIGR00813
transporter, SSS family; The Solute:Sodium Symporter (SSS) Family (TC 2.A.21) Members of the ...
45-442 6.97e-31

transporter, SSS family; The Solute:Sodium Symporter (SSS) Family (TC 2.A.21) Members of the SSS family catalyze solute:Na+ symport. The solutes transported may be sugars, amino acids, nucleosides, inositols, vitamins, urea or anions, depending on the system. Members of the SSS family have been identified in bacteria, archaea and animals, and all functionally well characterized members catalyze solute uptake via Na+ symport. Proteins of the SSS generally share a core of 13 TMSs, but different members of the family may have different numbers of TMSs. A 13 TMS topology with a periplasmic N-terminus and a cytoplasmic C-terminus has been experimentally determined for the proline:Na+ symporter, PutP, of E. coli. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273282 [Multi-domain]  Cd Length: 407  Bit Score: 124.72  E-value: 6.97e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319   45 GGRDIGLLVGGFTMTATWVGGGYINGTAEAVYGPGcgLAWAQAPIGYSLSLILGGLFFAKPMRSKGYVTMLDPFQQIYGK 124
Cdd:TIGR00813   1 AGRSLGGWVVAASLFASYISASQFLGLPGAIYAYG--FAIGFYELGALVLLIILGWLFVPIFINNGAYTMPEYLEKRFGK 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319  125 R----MGGLLFIPALMGEMfwAAAIFSAlGATISVIIDVDVNISVIVSALIAILYTLVGGLYSVAYTDVVQLFCIFIGLW 200
Cdd:TIGR00813  79 RilrgLSVLSLILYIFLYM--SVDLFSG-ALLIELITGLDLYLSLLLLGAITILYTVFGGLKAVVWTDTIQAVIMILGTF 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319  201 ISVPFALShpavtDIGFT-AVHAKYQSPWLGTIESVEVY-------TWLDNFLLLMLGGIPW-------QAYFQRVLSSS 265
Cdd:TIGR00813 156 ILPVFAFS-----EVGGLgTFVEKASQAAPTNPSPDDLYdffrdpsTSDLPWGAGVFGLPHValwywtnQVIVQRCLAAK 230
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319  266 SATYAQVLSFLAAFGCLVMALPAICIGAIGAS--TDWNQTaygyPDPKTKEEADMILPIVLQYLCPVYISFFGLGAVSAA 343
Cdd:TIGR00813 231 SAKHAKKGCLISGVLKLLPMFGAVLPGLIARAlyTDIDPA----LAGAVNQNSDQAYPLLVQELMPPGLAGLFLAAILAA 306
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319  344 VMSSADSSILSASSMFARNIYQLSFRQNAS-DKEIVWVMRITVLVFGASA-TAMALLTKTVYGLWYLSSDLVYIIIFPQL 421
Cdd:TIGR00813 307 VMSTLSSQLNSASTVFTMDLYKKIIRPNASgEKKIVMRGRIAVLVAAVIAgFVAAAQGGQVLQYVQEAFGGLGAPFLPVF 386
                         410       420
                  ....*....|....*....|.
gi 569001319  422 LCVLFIKGTNTYGAVAGYIFG 442
Cdd:TIGR00813 387 LLGIFWKRMNAKGALAGMIAG 407
SSF pfam00474
Sodium:solute symporter family; This family includes Swiss:P33413 which is not in the Prosite ...
43-442 3.68e-26

Sodium:solute symporter family; This family includes Swiss:P33413 which is not in the Prosite entry. Membership of this family is supported by a significant blast score.


Pssm-ID: 109527 [Multi-domain]  Cd Length: 406  Bit Score: 110.89  E-value: 3.68e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319   43 IVGGRDIGLLVGGFTMTATWVGGGYINGTAEAVYGpgCGLAWAQAPIGYSLSLILGGLFFAKPMRSKGYVTMLDPFQQIY 122
Cdd:pfam00474   2 FLAGRSMTGFVNGLSLAASYMSAASFVGLAGAGAA--SGLAGGLYAIGALVGVWLLLWLFAPRLRNLGAYTMPDYLRKRF 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319  123 GKR--------MGGLLFIPALMGEMFWAAAIFsalgatISVIIDVDVNISVIVSALIAILYTLVGGLYSVAYTDVVQLFC 194
Cdd:pfam00474  80 GGKrilvylsaLSLLLYFFTYMSVQIVGGARL------IELALGLNYYTAVLLLGALTAIYTFFGGFLAVSWTDTIQAVL 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319  195 IFIGLWISVPFALSHPAvtdiGFTAVHAKYQS--PWLGTIESVEVYTWLDNFL-------LLMLGGIPWQAYFQRVLSSS 265
Cdd:pfam00474 154 MLFGTIILMIIVFHEVG----GYSSAVEKYMTadPNGVDLYTPDGLHILRDPLtglslwpGLVLGTTGLPHILQRCLAAK 229
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319  266 SATYAqVLSFLAAFGCLVMALPaiciGAIGASTDWNQTAYGYPDPKTKE--EADMILPIVLQYLCPVYISFFGLGAVSAA 343
Cdd:pfam00474 230 DAKCI-RCGVLILTPMFIIVMP----GMISRGLFAIALAGANPRACGTVvgCSNIAYPTLAVKLGPPGLAGIMLAVMLAA 304
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319  344 VMSSADSSILSASSMFARNIYQLSFRQN-ASDKEIVWVMRITVLVFGASATAMALLTKTVYGLWYLSSDLVYI--IIFPQ 420
Cdd:pfam00474 305 IMSTLTSQLLSSSSAFTHDLYKNIRRKAsATEKELVGRSRIIVLVVISLAILLAVQPAQMGIAFLVQLAFAGLgsAFLPV 384
                         410       420
                  ....*....|....*....|..
gi 569001319  421 LLCVLFIKGTNTYGAVAGYIFG 442
Cdd:pfam00474 385 ILLAIFWKRVNEQGALWGMIIG 406
PRK15419 PRK15419
sodium/proline symporter PutP;
1-396 6.40e-13

sodium/proline symporter PutP;


Pssm-ID: 185317  Cd Length: 502  Bit Score: 71.20  E-value: 6.40e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319   1 MSFHVEGLVAIILFYLLIFLVGIWAAWKTKNSGNpeerseaIIVGGRDIGLLVGGFTMTATWVGGGYINGTAEAVYGPGC 80
Cdd:PRK15419   1 MAISTPMLVTFCVYIFGMILIGFIAWRSTKNFDD-------YILGGRSLGPFVTALSAGASDMSGWLLMGLPGAVFLSGI 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319  81 GLAWAQapIGYSLSLILGGLFFAKPMR-----SKGYVTMLDPFQQIYGKRMGGLLFIPALMGEMFWAAAIFSALGATISV 155
Cdd:PRK15419  74 SESWIA--IGLTLGAWINWKLVAGRLRvhteyNNNALTLPDYFTGRFEDKSRILRIISALVILLFFTIYCASGIVAGARL 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319 156 I---IDVDVNISVIVSALIAILYTLVGGLYSVAYTDVVQLFCIFIGLWISvpfalshPAVTDIGFTAVHAKYQSPWLGTI 232
Cdd:PRK15419 152 FestFGMSYETALWAGAAATILYTFIGGFLAVSWTDTVQASLMIFALILT-------PVIVIISVGGFGDSLEVIKQKSI 224
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319 233 ESVEVYTWLDNFLLLMLGGipWQ----------AYFQRVLSSSSATYAQVLSFLAAFGCLVmalPAICIGAIGASTDWNQ 302
Cdd:PRK15419 225 ENVDMLKGLNFVAIISLMG--WGlgyfgqphilARFMAADSHHSIVHARRISMTWMILCLA---GAVAVGFFGIAYFNEH 299
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319 303 TAYGypdPKTKEEADMILPIVLQYLCPVYISFFGLGAVSAAVMSSADSSILSASSMFARNIYQLSFRQNASDKEIVWVMR 382
Cdd:PRK15419 300 PAVA---GAVNQNAERVFIELAQILFNPWIAGILLSAILAAVMSTLSCQLLVCSSAITEDLYKAFLRKHASQKELVWVGR 376
                        410
                 ....*....|....
gi 569001319 383 ITVLVFGASATAMA 396
Cdd:PRK15419 377 VMVLVVALVAIALA 390
 
Name Accession Description Interval E-value
SLC5sbd_CHT cd11474
Na(+)- and Cl(-)-dependent choline cotransporter CHT and related proteins; solute-binding ...
8-495 0e+00

Na(+)- and Cl(-)-dependent choline cotransporter CHT and related proteins; solute-binding domain; Na+/choline co-transport by CHT is Cl- dependent. Human CHT (also called CHT1) is encoded by the SLC5A7 gene, and is expressed in the central nervous system. hCHT1-mediated choline uptake may be the rate-limiting step in acetylcholine synthesis, and essential for cholinergic transmission. Changes in this choline uptake in cortical neurons may contribute to Alzheimer's dementia. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271368 [Multi-domain]  Cd Length: 464  Bit Score: 582.95  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319   8 LVAIILFYLLIFLVGIWAAWKTKNSGNpeerseaIIVGGRDIGLLVGGFTMTATWVGGGYINGTAEAVYGPGCGLAwAQA 87
Cdd:cd11474    1 LIGVILYYLLILGIGLWASRRVKSSED-------FLLAGRSLPLPVGVFTLFATWFGGETILGAAETFYEEGLGGV-AQD 72
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319  88 PIGYSLSLILGGLFFAKPMRSKGYVTMLDPFQQIYGKRMGGLLFIPALMGEMFWAAAIFSALGATISVIIDVDVNISVIV 167
Cdd:cd11474   73 PFGYALCLILGGLFFAKPMRRMGLLTLGDFFRQRYGRRVEVLLSIPAVLSYLGWVAAQLVALGLVLSVILGLPVETGILI 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319 168 SALIAILYTLVGGLYSVAYTDVVQLFCIFIGLWISVPFALSHPAVTDIG-FTAVHAKYQSPWLGTIEsvEVYTWLDNFLL 246
Cdd:cd11474  153 SAAIVLAYTLFGGMWSVAYTDVVQLIVIFVGLLVLVPFVLTNPGGVDIAsAAAAGKLRFFPWLGTKS--DWLIWIDAWLT 230
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319 247 LMLGGIPWQAYFQRVLSSSSATYAQVLSFLAAFGCLVMALPAICIGAIGASTDWNQTAYGypdpkTKEEADMILPIVLQY 326
Cdd:cd11474  231 LGLGSIPQQDVFQRVLSAKSEKTAQRLSLLAGVGYLLFAIPPLLIGLAAASIDPSLTQYG-----LEEDAQLILPLLLQY 305
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319 327 LCPVYISFFGLGAVSAAVMSSADSSILSASSMFARNIYQLSFRQNASDKEIVWVMRITVLVFGASATAMALLTKTVYGLW 406
Cdd:cd11474  306 LTPLWVQVLFLGALLSAVMSTADSALLAPSSVFSENIYKPPFRPKASDRELLWVMRISVVVFGAIATLMALTVESIYGLV 385
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319 407 YLSSDLVYIIIFPQLLCVLFIKGTNTYGAVAGYIFGLFLRITGGEPYLYLQPLIfypgyysdknGIYNQRFPFKTLSMVT 486
Cdd:cd11474  386 ELASDLVLVGLFVPLLAGLYWKRANTYGALAAIIVGLVLRLLGGELLLGLPADI----------PPQLQGFPFSTLAMVI 455

                 ....*....
gi 569001319 487 SFFTNICVS 495
Cdd:cd11474  456 GSLLPLAVS 464
PutP COG0591
Na+/proline symporter [Amino acid transport and metabolism];
8-447 4.30e-78

Na+/proline symporter [Amino acid transport and metabolism];


Pssm-ID: 440356 [Multi-domain]  Cd Length: 476  Bit Score: 254.36  E-value: 4.30e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319   8 LVAIILFYLLIFLVGIWAAWKTKNSgnpeersEAIIVGGRDIGLLVGGFTMTATWVGGGYINGTAEAVYGpgCGLAWAQA 87
Cdd:COG0591    6 LIIIILYLLLLLGIGLYASRRTKSL-------EDYFLAGRSLGWWVLALSLGATWLSAWTFLGVPGLAYA--YGLSALWY 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319  88 PIGYSLSLILGGLFFAKPMRSKGYVTMLDPFQQIYGKRMGGLLFIPALMGEMFWAAAIFSALGATISVIIDVDVNISVIV 167
Cdd:COG0591   77 ALGYALGALLLALFFAPRLRRLGALTIPEFLEKRFGRGLRLLAAIIILLFLLGYLAAQLVALGKLLEALFGIPYWLGILI 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319 168 SALIAILYTLVGGLYSVAYTDVVQLFCIFIGLWISVPFALSHPAvtdiGFTAVHAKYQSP----WLGTIESVEVYTWLDN 243
Cdd:COG0591  157 GALIVLLYTVLGGLRAVAWTDVLQGILMLVGLILLLIVALSALG----GFGELFAALPAPgllsLFPGLGFTGWLAFLGL 232
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319 244 FLLLMLGGIPWQAYFQRVLSSSSATYAQVLSFLAAFGCLVMALPAICIGAIgastdwnqtAYGYPDPKTKEEADMILPIV 323
Cdd:COG0591  233 FLAIGLGYFGQPHIVQRFLAAKSEKEARKAALIGGLLYLLFYLLAALIGLL---------ARALFPDLPLADPDLALPLL 303
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319 324 LQYLCPVYISFFGLGAVSAAVMSSADSSILSASSMFARNIYQLSFRQNASDKEIVWVMRITVLVFGASATAMALLTK-TV 402
Cdd:COG0591  304 ILELLPPGLAGLLLAAILAAAMSTADSQLLAASSVFTRDIYKPFIKPKASDKQLLRVSRLAVLVVGLLALLLALLFPsSI 383
                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*
gi 569001319 403 YGLWYLSSDLVYIIIFPQLLCVLFIKGTNTYGAVAGYIFGLFLRI 447
Cdd:COG0591  384 LDLVLLAWGGLGAALLPPLLLGLFWKRATKAGALAGMIAGLVVVL 428
SLC5sbd cd10322
Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding ...
8-467 4.19e-76

Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; This family represents the solute-binding domain of SLC5 proteins (also called the sodium/glucose cotransporter family or solute sodium symporter family) that co-transport Na+ with sugars, amino acids, inorganic ions or vitamins. Family members include: the human glucose (SGLT1, 2, 4, 5), chiro-inositol (SGLT5), myo-inositol (SMIT), choline (CHT), iodide (NIS), multivitamin (SMVT), and monocarboxylate (SMCT) cotransporters, as well as Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. Vibrio parahaemolyticus Na(+)/galactose cotransporter (vSGLT) has 13 transmembrane helices (TMs): TM-1, an inverted topology repeat: TMs1-5 and TMs6-10, and TMs 11-12 (TMs numbered to conform to the solute carrier 6 family Aquifex aeolicus LeuT). One member of this family, human SGLT3, has been characterized as a glucose sensor and not a transporter. Members of this family are important in human physiology and disease.


Pssm-ID: 271357 [Multi-domain]  Cd Length: 454  Bit Score: 248.62  E-value: 4.19e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319   8 LVAIILFYLLIFLVGIWAAWKTKNSgnpeersEAIIVGGRDIGLLVGGFTMTATWVGGGYINGTAEAVYGPGCGLAWAQa 87
Cdd:cd10322    3 LIIVVVYLALLLGIGLYASKKVKSS-------EDFFLAGRSLGPWLLAGTLAATWISAGSFVGVAGLAYTYGLSAIWYI- 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319  88 pIGYSLSLILGGLFFAKPMRSKGYVTMLD-PFQQIYGKRMGGLLFIPALMGEMFWAAAIFSALGATISVIIDVDVNISVI 166
Cdd:cd10322   75 -LGAALGALLLALFLAPRLRRLGKTTIPEtILERYYSKGLRLLVAIIIIIALIPYLALQLIGGGYILSTLLGIPYTVAVI 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319 167 VSALIAILYTLVGGLYSVAYTDVVQLFCIFIGLWISVPFALSHPAVTDIGFTAVHAKYQSPWLGTIESVEVYTWLDNFLL 246
Cdd:cd10322  154 IAAVIVILYTVFGGMRAVAWTDVIQGIVMLIGVLVAAIFILSKVGGGGFSALAAALPALLLALGPGGGLGWSTILSLILL 233
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319 247 LMLGGIPWQAYFQRVLSSSSATYAQVLSFLAAFGCLVMALPAICIGAIGASTdwnqtaygYPDPktkEEADMILPIVLQY 326
Cdd:cd10322  234 TGLGVLALPQVFQRILAAKDEKTARRAFLLAGLLLLLIGFLVALIGLAARAL--------FPDL---ENPDLALPTLINS 302
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319 327 LCPVYISFFGLGAVSAAVMSSADSSILSASSMFARNIYQLSFRQNASDKEIVWVMRITVLVFGASATAMALLTKTVYGLW 406
Cdd:cd10322  303 LLPPGLAGLVLAGLLAAAMSTADSLLLAASTLFTRDIYKPLINPKASDKKLLRVSRIAVVVVGVLALLLALLPPSILLLL 382
                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 569001319 407 YLSSDLVYIIIFPQLLCVLFIKGTNTYGAVAGYIFGLFLRItGGEPYLYLQPLIFYPGYYS 467
Cdd:cd10322  383 SLAAGLLAAALFPPLLGGLFWKRATKAGAIAGIIVGLIVTL-VWLLLPLASPLGIDPIIPA 442
SLC5sbd_PutP cd11475
Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Escherichia coli ...
8-444 1.23e-36

Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Escherichia coli PutP catalyzes the Na+-coupled uptake of proline with a stoichiometry of 1:1. The putP gene is part of the put operon; this operon in addition encodes a proline dehydrogenase, allowing the use of proline as a source of nitrogen and/or carbon. This subfamily also includes the Bacillus subtilis Na+/proline cotransporter (OpuE) which has an osmoprotective instead of catabolic role. Expression of the opuE gene is under osmotic control and different sigma factors contribute to its regulation; it is also a putative CcpA-activated gene. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271369  Cd Length: 464  Bit Score: 142.26  E-value: 1.23e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319   8 LVAIILFYLLIFLVGIWAAWKTKNSgnpeersEAIIVGGRDIGLLVGGFTMTATWVGGGYINGTAEAVYGpgCGLAWAQA 87
Cdd:cd11475    1 LITFIVYLLLMLGIGIYSYRKTKTL-------EDYFLGGRSLGPWVTALSAGASDMSGWLLLGLPGAAYA--SGLSAIWI 71
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319  88 PIGYSLSLILGGLFFAKPMRS----KGYVTMLDPFQQIYGKRMGGLLFIPALM---GEMFWAAAIFSALGATISVIIDVD 160
Cdd:cd11475   72 AIGLILGAYLNWLFVAKRLRRytekNDSITLPDYLENRFRDKSKLLRILSALIiliFFTIYAAAQLVAGGKLFESLFGID 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319 161 VNISVIVSALIAILYTLVGGLYSVAYTDVVQLFCIFIGLWISVPFALSH---PAVTDIGFTAVHAKYQSPWLGTIESVEV 237
Cdd:cd11475  152 YSTGLLIGAVVVVAYTFLGGFLAVSWTDFFQGLLMLLALVLVPIVALAAlggLSGLVAALAAIDPGLLSPFGGDLGAGGL 231
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319 238 YTwldnFLLLMLGGIpwqAYF------QRVLSSSSATYAQVLSFLAAFGCLVMALPAICIGAIGAstdwnqtAYgYPDPK 311
Cdd:cd11475  232 LA----IISLLAWGL---GYFgqphilVRFMAIRSPKEIKKARRIAMVWMILFLLGAVLVGLLGR-------AL-FPDGL 296
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319 312 TkEEADMILPIVLQYLCPVYISFFGLGAVSAAVMSSADSSILSASSMFARNIYQLSFRQNASDKEIVWVMRITVLVFGAS 391
Cdd:cd11475  297 L-GDPETVFPVLAQELFPPWLAGILLAAILAAIMSTADSQLLVCSSALTEDLYKAFLRKEASDKELVWVSRLAVLVIALI 375
                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 569001319 392 ATAMAL-LTKTVYGL----W-YLSSDLVyiiifPQLLCVLFIKGTNTYGAVAGYIFGLF 444
Cdd:cd11475  376 ALLIALnPPSSVFSLvsfaWaGLGAAFG-----PLLLLSLYWKRTTRQGALAGMIAGAV 429
YidK COG4146
Uncharacterized membrane permease YidK, sodium:solute symporter family [General function ...
1-445 5.56e-35

Uncharacterized membrane permease YidK, sodium:solute symporter family [General function prediction only];


Pssm-ID: 443317 [Multi-domain]  Cd Length: 444  Bit Score: 137.20  E-value: 5.56e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319   1 MSFHVEGLVAIILFYLLIFLVGIWAAWKTKnsgnpEERSEAIIVGGRDIGLLVGGFTMTATWVGGGYINGTAEAVYGpgC 80
Cdd:COG4146    1 MGLSTLDYIVFLLYFLLVAGIGYWVSRKKK-----EKTSEDYFLAGRSLTWWVIGASLIATNISAEQLIGLNGSGYA--T 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319  81 GLAWAQAPIGYSLSLILGGLFFAKPMRSKGYVTMLDPFQQIYGKRMGGLLFIPALMGEMF-WAAAIFSALGATISVIIDV 159
Cdd:COG4146   74 GLAVAAYEWMAAIALIILALFFLPFYLKSGIYTMPEFLEKRYDRRTRTILSILFLVSYVFvNLPSVLYAGALALNTIFGV 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319 160 DVNISVIVSALIAILYTLVGGLYSVAYTDVVQLFCIFIGLWISVPFALShpAVTDIGF-------TAVHAKYQSPWLGti 232
Cdd:COG4146  154 PLWISVIGLGIIAGIYTIFGGLKAVAYTDVIQGIGLIIGGLLITVLGLD--AVGDGSVlagwsalLKVPPEKFNMIGP-- 229
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319 233 ESVEVYTWLDNFLLLMLGGIP-W---QAYFQRVLSSSSATYAQVLSFLAAF----GCLVMALPAICIGAIgastdwnqta 304
Cdd:COG4146  230 ADDPDLPWLGIFTGMPILNLFyWgtnQYIVQRALGAKNLKEAQKGVLFAGFlkllIPFIVVLPGIIAFVL---------- 299
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319 305 ygYPDPKTKeeADMILPIVLQYLCPVYISFFGLGAVSAAVMSSADSSILSASSMFARNIYQLSFRQNASDKEIVWVMRIT 384
Cdd:COG4146  300 --FPDGLDN--PDQAYPTLVKNLLPVGLKGLVAAALFAAIMSSLASALNSSSTLFTLDIYKKYFNPNASEKQLVKVGRIA 375
                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 569001319 385 VLVFGASATAMALLTKTVYGLW-YLSSdlVYIIIFPQLLCV----LFIKGTNTYGAVAGYIFGLFL 445
Cdd:COG4146  376 TVVLAVIAILIAPLIGNADGLFqYIQE--VTGFFSPPILAVfllgLFWKRVTAKAAKVALIAGIVL 439
sss TIGR00813
transporter, SSS family; The Solute:Sodium Symporter (SSS) Family (TC 2.A.21) Members of the ...
45-442 6.97e-31

transporter, SSS family; The Solute:Sodium Symporter (SSS) Family (TC 2.A.21) Members of the SSS family catalyze solute:Na+ symport. The solutes transported may be sugars, amino acids, nucleosides, inositols, vitamins, urea or anions, depending on the system. Members of the SSS family have been identified in bacteria, archaea and animals, and all functionally well characterized members catalyze solute uptake via Na+ symport. Proteins of the SSS generally share a core of 13 TMSs, but different members of the family may have different numbers of TMSs. A 13 TMS topology with a periplasmic N-terminus and a cytoplasmic C-terminus has been experimentally determined for the proline:Na+ symporter, PutP, of E. coli. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273282 [Multi-domain]  Cd Length: 407  Bit Score: 124.72  E-value: 6.97e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319   45 GGRDIGLLVGGFTMTATWVGGGYINGTAEAVYGPGcgLAWAQAPIGYSLSLILGGLFFAKPMRSKGYVTMLDPFQQIYGK 124
Cdd:TIGR00813   1 AGRSLGGWVVAASLFASYISASQFLGLPGAIYAYG--FAIGFYELGALVLLIILGWLFVPIFINNGAYTMPEYLEKRFGK 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319  125 R----MGGLLFIPALMGEMfwAAAIFSAlGATISVIIDVDVNISVIVSALIAILYTLVGGLYSVAYTDVVQLFCIFIGLW 200
Cdd:TIGR00813  79 RilrgLSVLSLILYIFLYM--SVDLFSG-ALLIELITGLDLYLSLLLLGAITILYTVFGGLKAVVWTDTIQAVIMILGTF 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319  201 ISVPFALShpavtDIGFT-AVHAKYQSPWLGTIESVEVY-------TWLDNFLLLMLGGIPW-------QAYFQRVLSSS 265
Cdd:TIGR00813 156 ILPVFAFS-----EVGGLgTFVEKASQAAPTNPSPDDLYdffrdpsTSDLPWGAGVFGLPHValwywtnQVIVQRCLAAK 230
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319  266 SATYAQVLSFLAAFGCLVMALPAICIGAIGAS--TDWNQTaygyPDPKTKEEADMILPIVLQYLCPVYISFFGLGAVSAA 343
Cdd:TIGR00813 231 SAKHAKKGCLISGVLKLLPMFGAVLPGLIARAlyTDIDPA----LAGAVNQNSDQAYPLLVQELMPPGLAGLFLAAILAA 306
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319  344 VMSSADSSILSASSMFARNIYQLSFRQNAS-DKEIVWVMRITVLVFGASA-TAMALLTKTVYGLWYLSSDLVYIIIFPQL 421
Cdd:TIGR00813 307 VMSTLSSQLNSASTVFTMDLYKKIIRPNASgEKKIVMRGRIAVLVAAVIAgFVAAAQGGQVLQYVQEAFGGLGAPFLPVF 386
                         410       420
                  ....*....|....*....|.
gi 569001319  422 LCVLFIKGTNTYGAVAGYIFG 442
Cdd:TIGR00813 387 LLGIFWKRMNAKGALAGMIAG 407
SLC5sbd_u3 cd11479
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 ...
11-442 2.72e-29

Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 (also called the sodium/glucose cotransporter family or solute sodium symporter family) is a family of proteins that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. Prokaryotic members of this family include Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271373  Cd Length: 454  Bit Score: 120.79  E-value: 2.72e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319  11 IILFYLLIFLVGIWAAWKTKNSgnpeersEAIIVGGRDIGLLVGGFTMTATWVGGGYINGTAEAVYGPGCGLAWAQAPIG 90
Cdd:cd11479    6 IALYFAAMIAIGWWGMRRAKTS-------EDYLVAGRRLGPGLYLGTMAAVVLGGASTIGGVGLGYQYGISGMWLVVAIG 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319  91 ysLSLILGGLFFAKPMRSKGYVTMLDPFQQIYGKRMGGLLFIPALMGEMFWAAAIFSALGATISVIIDVDVNISVIVSAL 170
Cdd:cd11479   79 --LGILALSLLLAKRIARLKVYTVSEVLELRYGPSARVISALVMLAYTLMVAVTSTIAIGTVFSVLFGLPRTLSILVGGG 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319 171 IAILYTLVGGLYSVAYTDVVQLFCIFIGLW-ISVPFALSHPAvtdiGFTAVHAKYQSPWLGtIESVEVYTWLDNFLLLML 249
Cdd:cd11479  157 IVVLYSVLGGMWSITLTDIIQFVIKTIGIFlLLLPLALSKAG----GLSGLQEKLPASYFD-LTSIGWDTIVTYFLLYFF 231
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319 250 GGIPWQAYFQRVLSSSSATYAQVLSFLAAFGCLVMALPAICIGAIGASTdwnqtaygYPDPKTKEEAdmiLPIVLQYLCP 329
Cdd:cd11479  232 GILIGQDIWQRVFTARSEKVARWGGVAAGLYCVLYGVAGALIGMAAAVL--------LPDLANPQNA---FATMAQEVLP 300
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319 330 VYISFFGLGAVSAAVMSSADSSILSASSMFARNIYQLSFRQNASDKEIVWVMRITVLVFGASATAMALLTKTVYGLWYLS 409
Cdd:cd11479  301 VGLRGLVLAAALAAMMSTASGALLASSTVLTNDVLPRLRRKNESERSEVRLSRLFTLLLGVVVIVIAVLVNDVVAALTIA 380
                        410       420       430
                 ....*....|....*....|....*....|...
gi 569001319 410 SDLVYIIIFPQLLCVLFIKGTNTYGAVAGYIFG 442
Cdd:cd11479  381 YAILVGGLLVPILGGLFWKRATGAGALASMVAG 413
SLC5sbd_u1 cd11477
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 ...
8-463 2.76e-26

Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 (also called the sodium/glucose cotransporter family or solute sodium symporter family) is a family of proteins that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. Prokaryotic members of this family include Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271371  Cd Length: 493  Bit Score: 112.29  E-value: 2.76e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319   8 LVAIILFYLLIFLVGIWAAWKTKNSgnpeerSEAIIVGGRDIGLLVGGFTMTATWVGGGYINGTAEAVYGPGCGLAWAQA 87
Cdd:cd11477    3 WLVIALYFLLMLGIGLWFSKRASKS------TSDFFLGGRKLPWWLAGISMAATTFSADTFVAVAGIAYTYGIAGNWIWW 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319  88 PIGysLSLILGGLFFAKPMRSKGYVTMLDPFQQIYGKRMGGLL-----FIPALMGEMFWAAAIFSALGATISVIIDVDVN 162
Cdd:cd11477   77 LWA--VAGLIGAFVFARRWRRLRVLTDGEFPEERYGGRYGAPLrqfyaVYFALLSNVDILAWVFLAAIKVSAVFGPWDPW 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319 163 ISVIVSALIAILYTLVGGLYSVAYTDVVQLFCIFIGLWISVPFALSHPAvtdiGFTAVHAKYQSPWLGTIESVEVYTWLD 242
Cdd:cd11477  155 LTILILGLITLIYTVIGGLWAVVVTDVVQFVIAMAASIAVAVLALNAVG----GPGGLFAQLPEGHLDLFGSGLGASGFY 230
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319 243 NFLLLML---------GGIPWqAYFQRVLSSSSATYA-QVLSFLAA---FGCLVMALPAICIGAIgastdwnqtaygYPD 309
Cdd:cd11477  231 ITFFFILffgwyplsySGGGW-YLAQRYLSAKSEKAAkAAAWLFAAlylVRPWPWMLPALAALVL------------YPD 297
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319 310 PKTKEEA-DMILPIVLQYLCPVYISFFGLGAVSAAVMSSADSSILSASSMFARNIYQLSFRQNASDKEIVWVMRITVLVF 388
Cdd:cd11477  298 LDDPEADfELAYPMMIKEYLPAGLLGLVLAGLLAATMSTVSTHLNWGAAYLVNDIYKRFIKPNASEKHLLKVGRLATVLF 377
                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 569001319 389 GASATAMALLTKTVYGLWYLSSDLVYIIIFPQLLCV---LFIKGTNTYGAVAGYIFGLFLRITGGEPYLYLQPLIFYP 463
Cdd:cd11477  378 GLLSIVVALASDSIGGAFWIVLALGAGLGGPLILPWlwwRFNAWTEIWAMIASIIVGLVVSVLLKVFGLPEDFLFSFL 455
SSF pfam00474
Sodium:solute symporter family; This family includes Swiss:P33413 which is not in the Prosite ...
43-442 3.68e-26

Sodium:solute symporter family; This family includes Swiss:P33413 which is not in the Prosite entry. Membership of this family is supported by a significant blast score.


Pssm-ID: 109527 [Multi-domain]  Cd Length: 406  Bit Score: 110.89  E-value: 3.68e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319   43 IVGGRDIGLLVGGFTMTATWVGGGYINGTAEAVYGpgCGLAWAQAPIGYSLSLILGGLFFAKPMRSKGYVTMLDPFQQIY 122
Cdd:pfam00474   2 FLAGRSMTGFVNGLSLAASYMSAASFVGLAGAGAA--SGLAGGLYAIGALVGVWLLLWLFAPRLRNLGAYTMPDYLRKRF 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319  123 GKR--------MGGLLFIPALMGEMFWAAAIFsalgatISVIIDVDVNISVIVSALIAILYTLVGGLYSVAYTDVVQLFC 194
Cdd:pfam00474  80 GGKrilvylsaLSLLLYFFTYMSVQIVGGARL------IELALGLNYYTAVLLLGALTAIYTFFGGFLAVSWTDTIQAVL 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319  195 IFIGLWISVPFALSHPAvtdiGFTAVHAKYQS--PWLGTIESVEVYTWLDNFL-------LLMLGGIPWQAYFQRVLSSS 265
Cdd:pfam00474 154 MLFGTIILMIIVFHEVG----GYSSAVEKYMTadPNGVDLYTPDGLHILRDPLtglslwpGLVLGTTGLPHILQRCLAAK 229
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319  266 SATYAqVLSFLAAFGCLVMALPaiciGAIGASTDWNQTAYGYPDPKTKE--EADMILPIVLQYLCPVYISFFGLGAVSAA 343
Cdd:pfam00474 230 DAKCI-RCGVLILTPMFIIVMP----GMISRGLFAIALAGANPRACGTVvgCSNIAYPTLAVKLGPPGLAGIMLAVMLAA 304
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319  344 VMSSADSSILSASSMFARNIYQLSFRQN-ASDKEIVWVMRITVLVFGASATAMALLTKTVYGLWYLSSDLVYI--IIFPQ 420
Cdd:pfam00474 305 IMSTLTSQLLSSSSAFTHDLYKNIRRKAsATEKELVGRSRIIVLVVISLAILLAVQPAQMGIAFLVQLAFAGLgsAFLPV 384
                         410       420
                  ....*....|....*....|..
gi 569001319  421 LLCVLFIKGTNTYGAVAGYIFG 442
Cdd:pfam00474 385 ILLAIFWKRVNEQGALWGMIIG 406
SLC5sbd_SGLT1-like cd10329
Na(+)/glucose cotransporter SGLT1 and related proteins; solute binding domain; This subfamily ...
8-497 3.76e-26

Na(+)/glucose cotransporter SGLT1 and related proteins; solute binding domain; This subfamily includes the solute-binding domain of SGLT proteins that cotransport Na+ with various solutes. Its members include: the human glucose (SGLT1, -2, -4, -5 ), chiro-inositol (SGLT5), and myo-inositol (SMIT) cotransporters. It also includes human SGLT3 which has been characterized as a glucose sensor and not a transporter. It belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271363  Cd Length: 538  Bit Score: 112.28  E-value: 3.76e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319   8 LVAIILFYLLIFLVGIWAAWKTKNSgnpeerSEAIIVGGRDIGLLVGGFTMTATWVGGGYINGTAEAVYGPGcgLAWAQA 87
Cdd:cd10329    1 IVIIAVYFVAVIAIGLWSSRKKRST------VSGYFLAGRSMGWPVIGASLFASNIGSSHLVGLAGSGAASG--IAVGNY 72
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319  88 PIGYSLSLILGGLFFAKPMRSKGYVTMLDPFQQIYGKRMGGLLFIPALMGEMF-WAAAIFSALGATISVIIDVDVNISVI 166
Cdd:cd10329   73 EWNAAFVLLLLGWVFLPFYIRSGVSTMPEFLEKRFGGRSRVYLSVLSLILYVFtKISVDLYAGALVIKQLLGWDLYLSII 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319 167 VSALIAILYTLVGGLYSVAYTDVVQLFCIFIGlwisvPFALSHPAVTDIGFtavhakyqsPWLGTIESVEVYTWLDNFLL 246
Cdd:cd10329  153 VLLVITAIYTIAGGLKAVIYTDTLQAVILIIG-----SAILMFLAFNEVGG---------GWSAYMAAIPSGTAFHLFRP 218
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319 247 LMLGGIPW------------------QAYFQRVLSSSSATYAQVLSFLAAFGCL----VMALPaiciGAIGASTDWNQTA 304
Cdd:cd10329  219 PDDPDLPWpglllgypilgiwywctdQVIVQRVLAAKNLKHARRGALFAGYLKLlplfLMVLP----GMIARALFPDLVA 294
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319 305 YGYPDPKTKEEADMILPIVLQYLCPVYISFFGLGAVSAAVMSSADSSILSASSMFARNIYQLsFRQNASDKEIVWVMRIT 384
Cdd:cd10329  295 CVVPCGNGVGCSDIAYPTLVTELLPVGLRGLVLAVLLAALMSSLTSIFNSASTLFTMDIYKR-LRPEASEKELVRVGRIA 373
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319 385 VLVFGASATAMALLTKTVYG-LW-YLSSDLVYIIifPQLLCV----LFIKGTNTYGAVAGYIFGLFLRITGGEPYLYLQP 458
Cdd:cd10329  374 TLVVVVISILWAPIIQAQGGsLFnYIQSVLSYLA--PPIAAVfllgIFWKRTNEQGAFWGLIAGLVLGLVRLILEFAYGE 451
                        490       500       510
                 ....*....|....*....|....*....|....*....
gi 569001319 459 LIFYPGYYSDKNGIYnqrfpFKTLSMVTSFFTNICVSYL 497
Cdd:cd10329  452 PDTRPAIIGGIHFLY-----FAFLLFVVSVIVTVIVSLL 485
SLC5sbd_DUR3 cd11476
Na(+)/urea-polyamine cotransporter DUR3, and related proteins; solute-binding domain; Dur3 is ...
10-495 4.21e-26

Na(+)/urea-polyamine cotransporter DUR3, and related proteins; solute-binding domain; Dur3 is the yeast plasma membrane urea transporter. Saccharomyces cerevisiae DUR3 also transports polyamine. The polyamine uptake of S. cerevisiae DUR3 is activated upon its phosphorylation by polyamine transport protein kinase 2 (PTK2). S. cerevisiae DUR3 also appears to play a role in regulating the cellular boron concentration. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271370  Cd Length: 493  Bit Score: 111.91  E-value: 4.21e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319  10 AIILFYLLIFLVG-IWAAWKTKNSGNPEERSEAIIVGGRDIGLLVGGFTMTATWVGGGYINGTAEAVYGPGCGlawaqAP 88
Cdd:cd11476    2 GVVIGLGALFALLmVFITRLLKRYRGKNQSSEEFMTAGRSVGTGLTAAAIVSSWTWAATLLQSATVAYQYGVS-----GP 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319  89 IGYSLSLILGGLFFA------KPMRSKGYvTMLDPFQQIYGKRMGGLLFIPALMGEMFWAAAIFSALGATISVIIDVDVN 162
Cdd:cd11476   77 FWYASGATLQILLFAplairiKRLAPNAH-TLLEIVRARYGTAAHLVFLVFALFTNVIVLAMLLLGGSAVVNALTGMPIV 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319 163 ISVIVSALIAILYTLVGGLYSVAYTDVVQLFCIFIGLWISVPFALSH-----PAVTDIGFTAVHAKYQSPWLG----TIE 233
Cdd:cd11476  156 AASFLIPLGVLLYTLFGGLRATFLTDYIHTVIILIILLVFAFAVYTSsdigsPSKVYDLLQEAAPDLPVEGNQgsylTFK 235
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319 234 SVEVYTWLDNFLLLMLG-GIPWQAYFQRVLSSSSATYAQVlSFLAafGCLVMALPAICIGAIGASTdwnqTAYGYPDPKT 312
Cdd:cd11476  236 SKAGLIFGIINIVGNFGtVFLDQGYWQRAIAARPSAAVKG-YFLG--GLAWFAIPFLLATTLGLAA----LALGLNPTFE 308
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319 313 KEEADMILPIVLQYLCPVYISFFGLGAVSAAVMSSADSSILSASSMFARNIYQLSFRQNASDKEIVWVMRITVLVFGASA 392
Cdd:cd11476  309 EVSAGLVLPYVAAALLGKGGAAAVLVLLFMAVTSTASAELIAVSSIVTYDIYRTYINPNATGKQLLRVSRIAVIGFGLFM 388
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319 393 TAMALltktvyGLWYLSSDLVYII----------IFPqLLCVLFIKGTNTYGAVAGYIFGLflrITGgepylylqpLIFY 462
Cdd:cd11476  389 GGLAV------GLNYIGISLGWLLlfmgiligsaVFP-VALGLYWRRQTGTAAVVSPIAGL---VAG---------LAVW 449
                        490       500       510
                 ....*....|....*....|....*....|...
gi 569001319 463 PGYYSDKNGIYNQRFPFKTLSMVTSFFTNICVS 495
Cdd:cd11476  450 LVTAKSYYGEVNVDTTGGNYPMLAGNLVALFSP 482
PanF COG4145
Na+/panthothenate symporter [Coenzyme transport and metabolism];
2-443 3.92e-24

Na+/panthothenate symporter [Coenzyme transport and metabolism];


Pssm-ID: 443316  Cd Length: 484  Bit Score: 105.69  E-value: 3.92e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319   2 SFHVEGLVAIILFYLLIFLVGIWAAWKTKNSGNPEERSeaiiVGGRDIGLLVGGFTMTATWVGGGYINGTAEAVYGPGCG 81
Cdd:COG4145    1 MMNLAILIPLLIYLLLVLGIGIYASRKRSKGSFLEEYF----LGSRSMGGFVLAMTLAATYTSASSFIGGPGAAYKYGLG 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319  82 ---LAWAQAPIGYsLSLILGGLFFAKPMRSKGYVTMLDPFQQIYGKR----MGGLLFIPALMGEMfwaAAIFSALGATIS 154
Cdd:COG4145   77 wvlLAMIQVPTAF-LTLGVLGKKFAILGRKYNAVTLADWLRARYQSKalvlLAALLLLLFFIAFM---VAQFVGGARLLE 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319 155 VIIDVDVNISVIVSALIAILYTLVGGLYSVAYTDVVQLFCIFIG---LWISVPFALSHPAVTDIGFTAVHAKYQSPwLGT 231
Cdd:COG4145  153 TVTGISYTTGLLIFGVTVVLYTTIGGFRAVVLTDAIQGIIMLVGtvlLLIGVISAGGGIENIMSTLAAIDPNLVSP-TGP 231
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319 232 IESVEVYTWLDNFLLLMLGGIPWQAYFQRVLS---SSSATYAQVLsflaafGCLVMALPAICIGAIGastdwnqtAYGYP 308
Cdd:COG4145  232 DGFLPRPFVISFWILVGFGVIGLPHTAVRCMAykdSKSLHRAMII------GTIVVGLLMFGMHLIG--------VLGRA 297
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319 309 DPKTKEEADMILPIVLQYLCPVYISFFGLGAVSAAVMSSADSSILSASSMFARNIYQLSFRQNAS--DKEIVWVMRITVL 386
Cdd:COG4145  298 VLPDLTVPDQVIPTLMVKVLPPFLAGIFLAGPLAAIMSTVDSLLLQASSTIVKDLYLNYINPKASenEKKLKRLSKLVTL 377
                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 569001319 387 VFGAsatamalltkTVYGLWYLSSDLVYIII-----------FPQLLCVLFIKGTNTYGAVAGYIFGL 443
Cdd:COG4145  378 VLGL----------IVFLLALNPPDLIIWLNlfafggleaafFWPLVLGLYWKRANATGAIASMLVGV 435
SLC5sbd_NIS-like_u2 cd11494
uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative ...
10-463 1.28e-22

uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Proteins belonging to the same subfamily as this uncharacterized subgroup include i) NIS, which transports I-, and other anions including ClO4-, SCN-, and Br-, ii) SMVT, which transports biotin, pantothenic acid and lipoate, and iii) the Na(+)/monocarboxylate cotransporters, SMCT1 and 2. SMCT1 is a high-affinity transporter while SMCT2 is a low-affinity transporter. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271385 [Multi-domain]  Cd Length: 473  Bit Score: 101.14  E-value: 1.28e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319  10 AIILFYLLIFLVgiWAAWKTKNSGNpeerSEAIIVGGRDIGLLVGGFTMTATWVGG-GYINGTAEAVYGpgcGLAWAQAP 88
Cdd:cd11494    4 IVLVGYLLGILV--YGVYKGRGQKN----QEDYFLGGRSMPWWPIGLSIMATQASAiTFLSAPGQAYSD---GMRFVQYY 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319  89 IGYSLSLILGGLFFAKPMRSKGYVTMLDPFQQIYGKRMGGLLFIPALMGEMFWAAAIFSALGATISVIIDVDVNISVIVS 168
Cdd:cd11494   75 FGLPLAMIFLCITFVPVFYKLKVYTAYEYLERRFGLKTRLLTSILFLISRGLATGVTIYAPAIILSTILGWSLWLTILLI 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319 169 ALIAILYTLVGGLYSVAYTDVVQLFCIFIGLWISVPFALSHPAVTdiGFTAVHAKYQSPWLGTIESveVYTWLD--NFLL 246
Cdd:cd11494  155 GGITIIYTVLGGIKAVIWTDVIQMVIIWAGLFIAFGLLLKLLPVG--FVDALLVAGKSGRLNALDF--SFDLSDtyTFWS 230
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319 247 LMLGGI-PWQAYF-------QRVLSSSSATYAQVLSFLAAFGCLVMALPAICIGAI--------GASTDWNQTAYGYPDP 310
Cdd:cd11494  231 GLIGGFfLYLSYFgtdqsqvQRYLTAKSIKEARKSLLLNGFLKFPMQFFILLIGVLvfvfyqfnPFPVSFNPAEDETKDT 310
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319 311 KtkeeaDMILPIVLQYLCPVYISFFgLGAVSAAVMSSADSSILSASSMFARNIYQLSFRQNASDKEIVWVMRITVLVFGA 390
Cdd:cd11494  311 N-----YIFLRFVLNYLPPGVIGLL-IAAIFAAAMSSIDSALNSLATVTVIDIYRRFFKKDASDEHYLKVSRLLTVFWGL 384
                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 569001319 391 SATAMAL---LTKTVYGLWYLSSDLVYIIIFPQLLCVLFIKGTNTYGAVAGYIFGLFLRItggepYLYLQPLIFYP 463
Cdd:cd11494  385 LAIVFALfagLAGSLIEAVNKLGSLFYGPILGVFLLAFFTKKANGKGVFAGAILGVIVVI-----VLWLFPDVSWL 455
SLC5sbd_PanF cd10327
Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute ...
8-443 4.48e-18

Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; PanF catalyzes the Na+-coupled uptake of extracellular pantothenate for coenzyme A biosynthesis in cells. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 212037  Cd Length: 472  Bit Score: 87.26  E-value: 4.48e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319   8 LVAIILFYLLIFLVGIWAAWKTKNSGNPEerSEAIIVGGRDIGLLVGGFTMTATWVGGGYINGTAEAVYGPGCG---LAW 84
Cdd:cd10327    2 LLPIIIYLVILLGIGFYARRSKKRRSGDF--LEEYFIGGRSMGGFVLAMTLVATYTSASSFIGGPGAAYKIGLGwvlLAM 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319  85 AQAPIGYslsLILG--GLFFAKPMRSKGYVTMLDPFQQIYGKRmgGLLFIPALMGEMFWAAAIFSAL--GAT-ISVIIDV 159
Cdd:cd10327   80 IQVPTGF---LTLGvlGKKFAIIARKINAVTIIDYLRARYNSK--ALVVLSSLALIVFFIAAMVAQFigGARlLEAVTGL 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319 160 DVNISVIVSALIAILYTLVGGLYSVAYTDVVQLFCIFIG---LWISVPFALSHPAVTDIGFTAVHAKYQSPWLGTIESVE 236
Cdd:cd10327  155 SYVTGLLIFGLTVILYTTIGGFRAVALTDAIQGIVMIIGtvlLLVGVLAAGGGMEAIMATLAEIDPNLLTPFGPGFLSPP 234
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319 237 VYtwLDNFLLLMLG--GIPWQAyfQRVLS---SSSATYAQVL-SFLAAFGCLVMALpaicIGAIGASTdwnqtaygYPDP 310
Cdd:cd10327  235 YI--LSFWVLVGFGviGLPQTA--VRCMGykdSKSMHRAMIIgTVVVGFLMLGMHL----AGVLGRAV--------LPDL 298
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319 311 ktkEEADMILPIVLQYLCPVYISFFGLGAVSAAVMSSADSSILSASSMFARNIYQLSFR--QNASDKEIVWVMRITVLVF 388
Cdd:cd10327  299 ---EVPDKVIPTLALKVLPPWLAGLFLAGPLAAIMSTVDSQLILASSAIVKDLYLNYKNkeKKTSEKKVKRISLIITIIL 375
                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 569001319 389 GASATAMALLTKTVyglwylssdLVYIIIFP----------QLLCVLFIKGTNTYGAVAGYIFGL 443
Cdd:cd10327  376 GLLVFLLAINPPDL---------IVWLNLFAfggleaaffwPLVLGLYWKRANATGALASMVVGL 431
SLC5sbd_u2 cd11478
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 ...
137-427 6.19e-18

Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 (also called the sodium/glucose cotransporter family or solute sodium symporter family) is a family of proteins that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. Prokaryotic members of this family include Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271372  Cd Length: 496  Bit Score: 86.96  E-value: 6.19e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319 137 GEMFWAAAIFsalgatISVIIDVDVNISVIVSALIAILYTLVGGLYSVAYTDVVQLFCIFIGLwisvpFALSHPAVTDI- 215
Cdd:cd11478  130 GINLYALALV------LNVLLGWPLWLSIILSAAIVLAYTTLGGLTSAIYNEVLQFFLIVAGL-----IPLVIIGLIKVg 198
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319 216 GFTAVHAKYQSPWLGTIESVEVYTWLDNF---------LLLMLGGIPWQAYF-------QRVLSSSSATYAQVLSFLAAF 279
Cdd:cd11478  199 GWDGLSEKIDANGPPGWNGLSWGPQGSQStnpmgvnlgLVFGLGFVLSFGYWttnflevQRAMAAKDLSAARRTPLIAAF 278
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319 280 gcLVMALPAICI--GAIGASTDWNQTAYGYPDPktkeeaDMILPIVLQYLCPVYISFFGLGAVSAAVMSSADSSILSASS 357
Cdd:cd11478  279 --PKMFIPFLVIlpGLIALVLVPELGASGGLDY------NQALPYLMAKYLPPGLLGLGITALLAAFMSGMAGNVSAFNT 350
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319 358 MFARNIYQLSFRQNASDKEIVWVMRITVLVfgasATAMALLTKtvyglwYLSSDLVYIIIFPQLLCVLFI 427
Cdd:cd11478  351 VFTYDIYQTYIVKDAPDKHYLKVGRIATVV----GVLISIGTA------YIASSFNNIMDYLQLLFSFFN 410
SLC5sbd_vSGLT cd10325
Vibrio parahaemolyticus Na(+)/galactose cotransporter (vSGLT) and related proteins; solute ...
12-440 2.96e-17

Vibrio parahaemolyticus Na(+)/galactose cotransporter (vSGLT) and related proteins; solute binding domain; vSGLT transports D-galactose, D-glucose, and alpha-D-fucose, with a sugar specificity in the order of D-galactose >D-fucose >D-glucose. It transports one Na+ ion for each sugar molecule, and appears to function as a monomer. vSGLT has 13 transmembrane helices (TMs): TM-1, an inverted topology repeat: TMs1-5 and TMs6-10, and TMs 11-12 (TMs numbered to conform to the solute carrier 6 family Aquifex aeolicus LeuT). This subfamily belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271360  Cd Length: 523  Bit Score: 85.05  E-value: 2.96e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319  12 ILFYLLIFLVGIWaawKTKNSGNPEERSEAIIVGGRDIGLLVGGFTMTATwvgggyiNGTAEAVYG-PGCGLAWAQAPIG 90
Cdd:cd10325    4 IVYVILIIGLGLW---VSREKKGGEKDATDYFLAGKSLPWWAIGASLIAA-------NISAEQFIGmSGSGFAIGLAIAS 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319  91 Y----SLSLILGGLFFAKPMRSKGYVTMLDPFQQIYGKRMGGLLFIPALMGEMFWAAAIFSALGA-TISVIIDVDVNISV 165
Cdd:cd10325   74 YewmaAITLIIVAKFFLPIFLKNGIYTMPQFLEERYDGRVRTIMAVFWLLLYVFVNLTSVLYLGAlAIETITGIPLTYSI 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319 166 IVSALIAILYTLVGGLYSVAYTDVVQLFCIFIGLWISVPFALSHPAVTDIGFTAVHAKYQSPW------LGTIESVEVYT 239
Cdd:cd10325  154 IGLALFAAAYSIYGGLKAVAWTDVIQVVFLVLGGLVTTYIALSLLGGGEGVFAGFTLLAAEAPehfhmiLDKSNPEDAYK 233
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319 240 WLDNfLLLMLGGIpWQAYF----------QRVLSSSSATYAQVLSFLAAFGCLVM----ALPAICIGAIGASTDWNQTAy 305
Cdd:cd10325  234 DLPG-IAVLLGGL-WVANLsywgfnqyiiQRALAAKSLSEAQKGIVFAAFLKLLIpfivVIPGIAAYVLASNLLLPAAT- 310
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319 306 gypdpkTKEEADMILPIVLQYLcPVYISFFGLGAVSAAVMSSADSSILSASSMFARNIYQLSFRQNASDKEIVWVMRITV 385
Cdd:cd10325  311 ------GIEKPDQAYPWLLRNL-PTGLKGLVFAALTAAIVSSLASMLNSISTIFTMDIYKKYIPKKASEKQLVNVGRLAA 383
                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 569001319 386 LVFGASATAMALLtktvygLWYLSSDLVYI-----IIFPQLLCV----LFIKGTNTYGAVAGYI 440
Cdd:cd10325  384 VIALIIAALIAPP------LLGLDQAFQYIqeytgFISPGILAIfllgLFWKRATSAGALVAAI 441
SLC5sbd_u4 cd11480
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 ...
8-497 1.29e-16

Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 (also called the sodium/glucose cotransporter family or solute sodium symporter family) is a family of proteins that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. Prokaryotic members of this family include Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271374  Cd Length: 488  Bit Score: 82.55  E-value: 1.29e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319   8 LVAIILFYLLIFLVGIWAAWKTKNSgnpeersEAIIVGGRDIGLLVGGFTMTATWVGGGYINGTAEAVYGPGCGLAWAqa 87
Cdd:cd11480    1 IGLFFVFVTITLYITIWAARRTRST-------SDFYVAGRGVPPVQNGLAIAGDYMSAASFLGIAGLIALSGYDGLAY-- 71
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319  88 PIGYSLSLILGGLFFAKPMRSKGYVTMLDpF--QQIYGKRMGGLLFIPALMGEMFWAAAIFSALGATISVIIDVDVNISV 165
Cdd:cd11480   72 AIGWTGGYVLLLLLVAEPLRNFGKYTVPD-FlgARLGSRPVRLVAAVSTLVISFFYLVAQMVGAGLLLSLLLGIPYEVGV 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319 166 IVSALIAILYTLVGGLYSVAYTDVVQLFCIFIGLWISVPFALSH----PAVTDIGFTAVHAKYQSPWLGTIESVEVYTW- 240
Cdd:cd11480  151 VVVGALMIVYVVLGGMRATTWVQIIQYVLLLGAFLVPAILVLARfggnPLGAGPGLLGLAAAAASGAGEAYLAPGLLLTd 230
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319 241 -LDNFLL---LMLG--GIPwqAYFQRVLSSSSATYAQVLSFLAAFGCLVMALPAICIGAIGASTDWNQTAYGYPDPKTKE 314
Cdd:cd11480  231 pLDVISLtlaLMLGtaGLP--HVLMRFYTVPDARAARKSVVWALGFIGLFYLLAPALGFGARALVGPDVIGAPIAGELDG 308
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319 315 EADMILPIVLQYLCPVYIsFFGL---GAVsAAVMSSADSSILSASSMFARNIYQLSFRQNASDKEIVWVMRITVLVFGAS 391
Cdd:cd11480  309 GGDMAVLLLPEIAGLGDL-LLALvaaGAF-AAILATVAGLLLAAASALAHDLYAGVIRPGASERREVRVARIAAVVVGVI 386
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319 392 ATAMALLTKTvyglwylsSDLVYII----------IFPQLLCVLFIKGTNTYGAVAGYIFGLFLRITggepYLYLQPLIF 461
Cdd:cd11480  387 AILLALLFPP--------QNVAFLValafaiaasaFFPVLVLGIFWRRFTTRGAIAGMLVGLLVSLV----LIVLSPAVS 454
                        490       500       510
                 ....*....|....*....|....*....|....*....
gi 569001319 462 YPGYYSDKNGiynqrFPFK---TLSMVTSFFTNICVSYL 497
Cdd:cd11480  455 GAPPGHDFAG-----FPLTnpgLVSVPLGFLVAIVVSLL 488
SLC5sbd_SGLT6 cd11490
Na(+)/chiro-inositol cotransporter SGLT6 and related proteins; solute-binding domain; Human ...
8-531 9.42e-16

Na(+)/chiro-inositol cotransporter SGLT6 and related proteins; solute-binding domain; Human SGLT6 (also called KST1, SMIT2) is a chiro-inositol transporter, which also transports myo-inositol. It is encoded by the SLC5A11 gene. Xenopus Na1-glucose cotransporter type 1 (SGLT-1)-like protein is predicted to contain 14 membrane-spanning regions. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271381  Cd Length: 602  Bit Score: 80.34  E-value: 9.42e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319   8 LVAIILFYLLIFLVGIWAAWKTKNSgnpeeRSEAIIVGGRDIGLLVGGFTMTATWVGGGYINGTAeavygpGCGLAWAQA 87
Cdd:cd11490    2 IVVLVLYFLFVLAVGLWSMWKTKRS-----TVKGYFLAGKDMTWWPVGASLFASNVGSGHFIGLA------GSGAAAGIG 70
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319  88 PIGYSLS-----LILGGLFFakPMRSKGYVTMLDPFQQiygKRMGGLLfIPALMGEMFWAAAIFSAL------GAT-ISV 155
Cdd:cd11490   71 VVAYEWNglfmvLVLAWLFL--PIYIASRVTTMPEYLK---KRFGGKR-IQIFLAVLYLFIYIFTKIsvdmyaGAVfIQQ 144
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319 156 IIDVDVNISVIVSALIAILYTLVGGLYSVAYTDVVQLFCIFIGLWISVPFALSHPAvtdiGFTAVHAKYQSPwLGTIESV 235
Cdd:cd11490  145 ALQWDLYLAVVGLLGITALYTVAGGLAAVIYTDALQTIIMVIGALILMGYSFAEVG----GFEALLEKYFQA-IPSIRSP 219
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319 236 EVYTWL---DNFLLL---MLGGIPW------------------QAYFQRVLSSSSATYAQVLSFLAAF----GCLVMALP 287
Cdd:cd11490  220 NSTCGIpreDAFHIFrdpVTSDLPWpgvllgmsipslwywctdQVIVQRSLAAKNLSHAKGGSLLAAYlkvlPLFMMVIP 299
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319 288 aiciGAIGASTDWNQTAYGypDPKTKEE--------ADMILPIVLQYLCPVYISFFGLGAVSAAVMSSADSSILSASSMF 359
Cdd:cd11490  300 ----GMISRILFPDQVACA--DPEVCKEicgnpsgcSDIAYPKLVMELLPTGLRGLMMAVMLAALMSSLTSIFNSASTIF 373
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319 360 ARNIYQlSFRQNASDKEIVWVMRITVLVFGASATAMALLTKTVYG---LWYLSSDLVYIiifPQLLCVLFIKG-----TN 431
Cdd:cd11490  374 TMDLWR-HIRPRASEWELMIVGRVFVLVLVVVSILWIPLVQASQGgqlFIYIQSISSYL---QPPVAVVFIAGcfwkrTN 449
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319 432 TYGAVAGYIFGLFLRITGGE-PYLYLQPLIFYPgyysDKNGIYNQRFPFKTLSMVTSFFTNICVSYLAKYlfesgTLPPK 510
Cdd:cd11490  450 EKGAFWGLMVGLAVGLTRMVlDFIYVTPQCDQP----DTRPDIVKYVHYLYFSMILTILTLVVVVCVSLA-----TEPPS 520
                        570       580       590
                 ....*....|....*....|....*....|
gi 569001319 511 LDV---------FDAVVarhSEENMDKTIL 531
Cdd:cd11490  521 KEMisrltwftrFDAVV---ESEELKKAIL 547
ActP COG4147
Na+(or H+)/acetate symporter ActP [Energy production and conversion];
8-499 4.60e-15

Na+(or H+)/acetate symporter ActP [Energy production and conversion];


Pssm-ID: 443318  Cd Length: 526  Bit Score: 77.89  E-value: 4.60e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319   8 LVAIILFYLLIFLVGIWAAWKTKNSgnpeersEAIIVGGRDIGLLVGGFTMTATWVGGGYINGTAEAVYGPGC-GLAWAq 86
Cdd:COG4147   15 IGIFLVFVTFTLYITIWAARRTKST-------SDFYVAGRGVTGVQNGLAIAGDYMSAASFLGIAGLIALSGYdGLIYS- 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319  87 apIGYSLSLILGGLFFAKPMRSKGYVTMLDpfqqIYGKRMG----------GLLFIPAlmgemFWAAAIFSALGATISVI 156
Cdd:COG4147   87 --IGWLVGYVLLLLLLAEYLRNFGKFTVPD----FLGDRFYsrparlvaaiSTLVVSF-----FYLIAQMVGAGVLISLL 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319 157 IDVDVNISVIVSALIAILYTLVGGLYSVAYTDVVQ----LFCIFIG-LWISVPFALSHPAVTD--IGFTAVHAKYQSPWL 229
Cdd:COG4147  156 LGVDYEVAVVIVGVLMIVYVVLGGMKGTTWVQIIKavllIFAYTVPaVLVLAQFGFNPLPLLAkaAEVHDLGAAYLEPGG 235
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319 230 GtiesveVYTWLDNFLL---LMLG--GIPW---------QAYFQRvlssSSATYAQVLSFLAAFGCLVMALPAICIgaIG 295
Cdd:COG4147  236 L------VKSPLDFISLglaLMLGtaGLPHilmrfftvpDAKEAR----KSVGWALGFIGLFYLTAPALGFGARAL--VG 303
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319 296 ASTDWNQTAYGYPDPKTKEEADMILPIVLQyLCPVYISFFGLGAVsAAVMSSADSSILSASSMFARNIYQLSFRQNASDK 375
Cdd:COG4147  304 PLPEWFDTGLIGAADGGGNMAVLALAEIAG-GGNWLLGLVAAGAF-ATILAVVAGLLLAIASAISHDLYANVIKGKATEK 381
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319 376 EIVWVMRITVLVFGASATAMALLTKT--VYGLWYLSSDLVYIIIFPQLLCVLFIKGTNTYGAVAGYIFGLFLRITggepY 453
Cdd:COG4147  382 EELRVARIAAVVIGVVAILLGINAPPqnVAFLVALAFALAASANFPVLLLSIFWKRFNTRGAVAGMLVGLISALV----L 457
                        490       500       510       520
                 ....*....|....*....|....*....|....*....|....*....
gi 569001319 454 LYLQPLIFYPgyysdknGIYNQRFPFK---TLSMVTSFFTNICVSYLAK 499
Cdd:COG4147  458 IVLSPFVWVL-------GVDAALFPLEnpgLVSMPLGFLVAIVVSLLTP 499
SLC5sbd_NIS-like_u3 cd11495
uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative ...
3-443 3.95e-14

uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Proteins belonging to the same subfamily as this uncharacterized subgroup include i) NIS, which transports I-, and other anions including ClO4-, SCN-, and Br-, ii) SMVT, which transports biotin, pantothenic acid and lipoate, and iii) the Na(+)/monocarboxylate cotransporters SMCT1 and 2. SMCT1 is a high-affinity transporter while SMCT2 is a low-affinity transporter. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271386 [Multi-domain]  Cd Length: 473  Bit Score: 74.88  E-value: 3.95e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319   3 FHVEGLVAIILFYLLIFLVGIWAAWKTKNSgnpeersEAIIVGGRDIGLLVGGFTMTATWVGGGYINGTAEAVYGPGCGL 82
Cdd:cd11495    1 FGWLDYLVLVIYLLAMLGIGLYFSKKQKST-------DDYFKGGGRIPWWAAGLSIFATTLSSITFLAIPGKAYATDWNY 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319  83 AWAQapIGYSLSLILGGLFFAKPMRSKGYVTMLDPFQQIYGKRM---GGLLFIPALMGEMfwaAAIFSALGATISVIIDV 159
Cdd:cd11495   74 FVGS--LSIIIAAPLAAYFFVPFFRRLNVTSAYEYLEKRFGPWArvyGSLLFILFQLGRM---GIVLYLPALALSAVTGI 148
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319 160 DVNISVIVSALIAILYTLVGGLYSVAYTDVVQLFCIFIGLWISVPFALSHpavTDIGFTAV------HAKYqspWLGTie 233
Cdd:cd11495  149 NPYIIIILMGVLCIIYTVLGGIEAVIWTDVIQGVVLLGGALLCLIILLFS---IPGGFGEVfdiaiaNGKF---SLGD-- 220
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319 234 svEVYTWLDN-FLLLMLGGIPW--------QAYFQRVLSSSSATYAQVLSFLAAFGCLVMALPAICIGaigastdwnqTA 304
Cdd:cd11495  221 --FSFSLTEStIWVIFIGGIFNnlqsytsdQDVVQRYLTTKSIKEAKKSLWTNALLALPVALLFFGIG----------TA 288
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319 305 -YGY-----PDPKTKEEADMILP-IVLQYLcPVYISFFGLGAVSAAVMSSADSSILSASSMFARNIYQlSFRQNASDKEI 377
Cdd:cd11495  289 lYVFyqqhpELLPAGINGDAVFPyFIVTQL-PVGVAGLIIAAIFAAAMSTISSSLNSVATCITTDFYK-RLSPDPSDKQY 366
                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 569001319 378 VWVMRITVLVFGASATAMALL-----TKTVYGLWYLSSDLVYIIIFPQLLCVLFIKGTNTYGAVAGYIFGL 443
Cdd:cd11495  367 LKVARLITLLVGLLGTLVALYlanagVKSLLDAFNTLTGLFGGGLAGLFLLGIFTKRANAKGALVGIIVSI 437
SLC5sbd_SGLT2 cd11487
Na(+)/glucose cotransporter SGLT2 and related proteins; solute-binding domain; Human SGLT2 ...
11-445 6.56e-14

Na(+)/glucose cotransporter SGLT2 and related proteins; solute-binding domain; Human SGLT2 (hSGLT2) is a high-capacity, low-affinity glucose transporter, that plays an important role in renal glucose reabsorption. It is encoded by the SLC5A2 gene and expressed almost exclusively in renal proximal tubule cells. Mutations in hSGLT2 cause Familial Renal Glucosuria (FRG), a rare autosomal defect in glucose transport. hSGLT2 is a major drug target for regulating blood glucose levels in diabetes. hSGLT2 is predicted to have 14 membrane-spanning regions. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 212056 [Multi-domain]  Cd Length: 583  Bit Score: 74.57  E-value: 6.56e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319  11 IILFYLLIFLVGIWAAWKTkNSGNpeerSEAIIVGGRDIGLLVGGFTMTATWVGGGYINGTAEAvyGPGCGLAWAQAPIG 90
Cdd:cd11487    6 IAAYFLLVIGVGLWSMCRT-NRGT----VGGYFLAGRSMVWWPVGASLFASNIGSGHFVGLAGT--GAASGIAVAGFEWN 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319  91 YSLSLILGGLFFAKPMRSKGYVTMLDPFQQIYG-KRMGGLLFIPALMGEMFWAAAIFSALGAT-ISVIIDVDVNISVIVS 168
Cdd:cd11487   79 ALFVVLLLGWLFVPVYLTAGVITMPQYLKKRFGgQRIRLYLSVLSLFLYIFTKISVDMFSGAVfIQQALGWNIYASVIAL 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319 169 ALIAILYTLVGGLYSVAYTDVVQLFCIFIGLWISVPFALSHPAvtdiGFTAVHAKYQS----------PWLGTIESVEVY 238
Cdd:cd11487  159 LGITMIYTVTGGLAALMYTDTVQTFVIIGGACVLMGYAFHEVG----GYSALFEKYLKavpsltvsedPAVGNISSSCYR 234
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319 239 TWLDNFLLL---MLGGIPW------------------QAYFQRVLSSSSATYAQVLSFLAAF------------------ 279
Cdd:cd11487  235 PRPDSYHLLrdpVTGDLPWpalilgltivsswywcsdQVIVQRCLAARSLTHVKAGCILCGYlkllpmflmvmpgmisrv 314
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319 280 ------GCLVmalPAICIGAIGASTDWNQTAYgypdpktkeeadmilPIVLQYLCPVYISFFGLGAVSAAVMSSADSSIL 353
Cdd:cd11487  315 lypdevACVE---PSVCLRVCGTEVGCSNIAY---------------PKLVVKLMPNGLRGLMLAVMLAALMSSLASIFN 376
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319 354 SASSMFARNIYQlSFRQNASDKEIVWVMRITVLVFGASATAMALLTKTVYG---LWYLSSDLVYII--IFPQLLCVLFIK 428
Cdd:cd11487  377 SSSTLFTMDIWT-RLRPQAGDKELLLVGRVWVVCIVAVSVAWIPVVQAAQGgqlFDYIQSVSSYLAppIAAVFFLALFVK 455
                        490
                 ....*....|....*..
gi 569001319 429 GTNTYGAVAGYIFGLFL 445
Cdd:cd11487  456 RVNEPGAFWGLIGGLLM 472
SLC5sbd_SGLT1 cd11486
Na(+)/glucose cotransporter SGLT1;solute binding domain; Human SGLT1 (hSGLT1) is a ...
11-447 8.32e-14

Na(+)/glucose cotransporter SGLT1;solute binding domain; Human SGLT1 (hSGLT1) is a high-affinity/low-capacity glucose transporter, which can also transport galactose. In the transport mechanism, two Na+ ions first bind to the extracellular side of the transporter and induce a conformational change in the glucose binding site. This results in an increased affinity for glucose. A second conformational change in the transporter follows, bringing the Na+ and glucose binding sites to the inner surface of the membrane. Glucose is then released, followed by the Na+ ions. In the process, hSGLT1 is also able to transport water and urea and may be a major pathway for transport of these across the intestinal brush-border membrane. hSGLT1 is encoded by the SLC5A1 gene and expressed mostly in the intestine, but also in the trachea, kidney, heart, brain, testis, and prostate. The WHO/UNICEF oral rehydration solution (ORS) for the treatment of secretory diarrhea contains salt and glucose. The glucose, along with sodium ions, is transported by hSGLT1 and water is either co-transported along with these or follows by osmosis. Mutations in SGLT1 are associated with intestinal glucose galactose malabsorption (GGM). Up-regulation of intestinal SGLT1 may protect against enteric infections. SGLT1 is expressed in colorectal, head and neck, and prostate tumors. Epidermal growth factor receptor (EGFR) functions in cell survival by stabilizing SGLT1, and thereby maintaining intracellular glucose levels. SGLT1 is predicted to have 14 membrane-spanning regions. This subgroup belongs to the solute carrier 5 (SLC5)transporter family.


Pssm-ID: 271379  Cd Length: 636  Bit Score: 74.20  E-value: 8.32e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319  11 IILFYLLIFLVGIWAAWKTkNSGNpeerSEAIIVGGRDIGLLVGGFTMTATWVGGGYINGTAeavygpGCGLAWAQAPIG 90
Cdd:cd11486    6 IVIYFVVVLAVGVWAMVST-NRGT----VGGFFLAGRSMVWWPIGASLFASNIGSGHFVGIA------GTGAAAGIAIGG 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319  91 YS-----LSLILGGLFFAKPMRSkGYVTMLDPFQQIYG-KRMGGLLFIPALMGEMFW--AAAIFSalGAT-ISVIIDVDV 161
Cdd:cd11486   75 FEwnalvVVVVLGWLFVPIYIKA-GVVTMPEYLRKRFGgQRIQVYLSVLSLCLYIFTkiSADIFS--GAIfINLALGLNL 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319 162 NISVIVSALIAILYTLVGGLYSVAYTDVVQLFCIFIGLWISVPFALSHPAvtdiGFTAVHAKYQ-------SPWLGTIES 234
Cdd:cd11486  152 YLAIVILLAITALYTITGGLAAVIYTDTLQTIIMVVGSFILMGFAFNEVG----GYDAFMEKYMtaipsviGTGNSTSQE 227
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319 235 VEVYTWLDNFLLL---MLGGIPW------------------QAYFQRVLSSSSATYAQV-------LSFLAAFgCLVM-- 284
Cdd:cd11486  228 KCYTPRADSFHIFrdpITGDLPWpgllfglsiltlwywctdQVIVQRCLSAKNMSHVKAgcilcgyLKLLPMF-IMVMpg 306
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319 285 -------------ALPAICIGAIGASTDWNQTAYgypdpktkeeadmilPIVLQYLCPVYISFFGLGAVSAAVMSSADSS 351
Cdd:cd11486  307 misrilytdeiacVVPDECKAVCGTEVGCTNIAY---------------PKLVVELMPNGLRGLMLSVMLASLMSSLTSI 371
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319 352 ILSASSMFARNIYQlSFRQNASDKEIVWVMRITVLVFGASATAMALLTKTVYG---LWYLSSDLVYII--IFPQLLCVLF 426
Cdd:cd11486  372 FNSASTLFTMDIYT-KVRKKASEKELMIAGRLFMLVLIGISIAWVPIVQSAQSgqlFDYIQSITSYLGppIAAVFLLAIF 450
                        490       500
                 ....*....|....*....|.
gi 569001319 427 IKGTNTYGAVAGYIFGLFLRI 447
Cdd:cd11486  451 CKRVNEPGAFWGLCVGLLVGL 471
PRK15419 PRK15419
sodium/proline symporter PutP;
1-396 6.40e-13

sodium/proline symporter PutP;


Pssm-ID: 185317  Cd Length: 502  Bit Score: 71.20  E-value: 6.40e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319   1 MSFHVEGLVAIILFYLLIFLVGIWAAWKTKNSGNpeerseaIIVGGRDIGLLVGGFTMTATWVGGGYINGTAEAVYGPGC 80
Cdd:PRK15419   1 MAISTPMLVTFCVYIFGMILIGFIAWRSTKNFDD-------YILGGRSLGPFVTALSAGASDMSGWLLMGLPGAVFLSGI 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319  81 GLAWAQapIGYSLSLILGGLFFAKPMR-----SKGYVTMLDPFQQIYGKRMGGLLFIPALMGEMFWAAAIFSALGATISV 155
Cdd:PRK15419  74 SESWIA--IGLTLGAWINWKLVAGRLRvhteyNNNALTLPDYFTGRFEDKSRILRIISALVILLFFTIYCASGIVAGARL 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319 156 I---IDVDVNISVIVSALIAILYTLVGGLYSVAYTDVVQLFCIFIGLWISvpfalshPAVTDIGFTAVHAKYQSPWLGTI 232
Cdd:PRK15419 152 FestFGMSYETALWAGAAATILYTFIGGFLAVSWTDTVQASLMIFALILT-------PVIVIISVGGFGDSLEVIKQKSI 224
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319 233 ESVEVYTWLDNFLLLMLGGipWQ----------AYFQRVLSSSSATYAQVLSFLAAFGCLVmalPAICIGAIGASTDWNQ 302
Cdd:PRK15419 225 ENVDMLKGLNFVAIISLMG--WGlgyfgqphilARFMAADSHHSIVHARRISMTWMILCLA---GAVAVGFFGIAYFNEH 299
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319 303 TAYGypdPKTKEEADMILPIVLQYLCPVYISFFGLGAVSAAVMSSADSSILSASSMFARNIYQLSFRQNASDKEIVWVMR 382
Cdd:PRK15419 300 PAVA---GAVNQNAERVFIELAQILFNPWIAGILLSAILAAVMSTLSCQLLVCSSAITEDLYKAFLRKHASQKELVWVGR 376
                        410
                 ....*....|....
gi 569001319 383 ITVLVFGASATAMA 396
Cdd:PRK15419 377 VMVLVVALVAIALA 390
SLC5sbd_NIS-like_u1 cd11493
uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative ...
10-398 7.05e-13

uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Proteins belonging to the same subfamily as this uncharacterized subgroup include i) NIS, which transports I-, and other anions including ClO4-, SCN-, and Br-, ii) SMVT, which transports biotin, pantothenic acid and lipoate, and iii) the Na(+)/monocarboxylate cotransporters SMCT1 and 2. SMCT1 is a high-affinity transporter while SMCT2 is a low-affinity transporter. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271384 [Multi-domain]  Cd Length: 479  Bit Score: 71.09  E-value: 7.05e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319  10 AIILFYLL-IFLVGIWAAWKTKNSgnpeersEAIIVGGRDI------GLLVGGFTMTATWVGG---GYINGtaeavygpg 79
Cdd:cd11493    3 AVIVLYLLgLPLLGLWLSGRQKST-------ADYFLGGRSMpwwavcLSVVATETSTLTFLSIpglAYGGD--------- 66
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319  80 cgLAWAQAPIGYSLSLILGGLFFAKPMRSKGYVTMLDPFQQIYGKRMGGLLFIPALMGEMFWAAAIFSALGATISVIIDV 159
Cdd:cd11493   67 --LTFLQLALGYILGRIIVAFVLLPRYFRGEVVSAYELLGQRFGGGMQKTASVTFLVTRLLADGVRLFAAAIPVSMILGA 144
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319 160 D-----VNISVIVSALIAILYTLVGGLYSVAYTDVVQlFCIFIGLWISVPFALSHPAVTDIGFTAVHA-KYQSPWLG--T 231
Cdd:cd11493  145 DgvalsYIASILIISVVTLLYTYFGGIRAVVWTDVIQ-LVVYIGGAVAALAYLLGALPADWLQIAAAAgKFHLFDLSdlI 223
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319 232 IESVEVYTwldnFLLLMLGGIPW--------QAYFQRVL---SSSSATYAQVLSFLAAFgcLVMALpAICIGAIGAstdw 300
Cdd:cd11493  224 LGLTSPYT----FWAAIIGGALLsmashgtdQLMVQRLLacrNLRDAQKALIGSGVVVF--PQFAL-FLLIGLLLY---- 292
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319 301 nqTAYGYPDPKTKE--EADMILP-IVLQYLcPVYISFFGLGAVSAAVMSSADSSILSASSMFARNIYQLSFRQNASDKEI 377
Cdd:cd11493  293 --VYYGGASLAALGlgSPDEVFPyFIVHEL-PAGLRGLLIAGILAAAMSTLSSALNSLASSTVQDLYQPWKRRRLSDEKL 369
                        410       420
                 ....*....|....*....|.
gi 569001319 378 VWVMRITVLVFGASATAMALL 398
Cdd:cd11493  370 LRASRLLTLVWAVVLVGIALL 390
SLC5sbd_SGLT4 cd11488
Na(+)/glucose cotransporter SGLT4 and related proteins; solute-binding domain; Human SGLT4 ...
8-448 1.05e-12

Na(+)/glucose cotransporter SGLT4 and related proteins; solute-binding domain; Human SGLT4 (hSGLT4) has been reported to be a low-affinity glucose transporter with unusual sugar selectivity: it transports D-mannose but not galactose or 3-O-methyl-D-glucoside. It is encoded by the SLC5A9 gene and is expressed in intestine, kidney, liver, brain, lung, trachea, uterus, and pancreas. hSLGT4 is predicted to contain 14 membrane-spanning regions. This subgroup belongs to the solute carrier 5 (SLC5 )transporter family.


Pssm-ID: 271380  Cd Length: 605  Bit Score: 70.73  E-value: 1.05e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319   8 LVAIILFYLLIFLVGIWAAWKTkNSGNpeerSEAIIVGGRDIGLLVGGFTMTATWVGGGYINGTAEAvyGPGCGLAWAQA 87
Cdd:cd11488    2 IAVVVVYFVFVLAVGIWSSIRA-SRGT----VGGYFLAGRSMTWWPIGASLMSSNVGSGLFIGLAGT--GAAGGLAVGGF 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319  88 PIGYSLSLILGGLFFAKPMRSKGYVTMLDPFQ--------QIYGKRMGGLLFIPALMGEMFWAAAIFsalgatISVIIDV 159
Cdd:cd11488   75 EWNAAWVLIALGWIFVPVYIAAGVVTMPEYLKkrfggqriRIYMSVLSLILYIFTKISTDIFSGALF------IQVSLGW 148
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319 160 DVNISVIVSALIAILYTLVGGLYSVAYTDVVQLFCIFIGlwisvPFALSHPAVTDIG-FTAVHAKYQS--PWLGTIESVE 236
Cdd:cd11488  149 NLYLSTVILLAVTALYTIAGGLTAVIYTDALQTVIMVIG-----AFVLMFIAFDKVGwYPGLEQQYEKaiPALTVPNTTC 223
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319 237 VYTWLDNFLLL---MLGGIPW------------------QAYFQRVLSSSSATYAQVLSFLAAF------------GCLV 283
Cdd:cd11488  224 HLPRSDAFHIFrdpVTGDIPWpglifgltvlatwvwctdQVIVQRSLSAKNLSHAKGGSVLGGYlkilpmffvvmpGMIS 303
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319 284 MAL---------PAICIGAIGASTDWNQTAYgypdpktkeeadmilPIVLQYLCPVYISFFGLGAVSAAVMSSADSSILS 354
Cdd:cd11488  304 RALfpdevgcvdPDECQKICGAKVGCSNIAY---------------PKLVVELMPVGLRGLMIAVIMAALMSSLTSIFNS 368
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319 355 ASSMFARNIYQlSFRQNASDKEIVWVMRITVLVFGA-SATAMALLTKTVYGLW--YLSSDLVYII--IFPQLLCVLFIKG 429
Cdd:cd11488  369 SSTLFTMDVWQ-RIRRRASEQELMVVGRVFILLLVViSILWIPIIQTANSGQLfdYIQAVTSYLSppITAVFILAIFWKR 447
                        490
                 ....*....|....*....
gi 569001319 430 TNTYGAVAGYIFGLFLRIT 448
Cdd:cd11488  448 VNEPGAFWGLMVGLVVGLV 466
SLC5sbd_SGLT5 cd11489
Na(+)/glucose cotransporter SGLT5 and related proteins; solute-binding domain; Human SGLT5 is ...
5-448 1.52e-12

Na(+)/glucose cotransporter SGLT5 and related proteins; solute-binding domain; Human SGLT5 is a glucose transporter, which also transports galactose. It is encoded by the SLC5A10 gene, and is exclusively expressed in the renal cortex. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 212058  Cd Length: 604  Bit Score: 70.35  E-value: 1.52e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319   5 VEGLVAIILFYLLIFLVGIWAAWK-TKNSGNpeerseAIIVGGRDIGLLVGGFTMTATWVGGGYINGTAEAvyGPGCGLA 83
Cdd:cd11489    2 VADIIVIGVYFALNVAVGIWSSCRvSRNTVS------GYFLAGRDMAWWPIGASLFASSEGSGLFIGLAGT--GAAGGIA 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319  84 WAQAPIGYSLSLILGGLFFAKPMRSKGYVTMLDPFQQIYG-KRMGGLLFIPALMGEMFWAAAIFSALGAT-ISVIIDVDV 161
Cdd:cd11489   74 VAGFEWNATYALLALAWVFVPVYISSGIVTMPEYLQRRFGgERIRMYLSVLSLLLSVFTKISTDLYSGALfVQVCLGWNL 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319 162 NISVIVSALIAILYTLVGGLYSVAYTDVVQLFCIFIGLWIsvpfaLSHPAVTDIGFtavHAKYQSPWLGTIESVEV---- 237
Cdd:cd11489  154 YLSTVLMLVVTALYTIAGGLAAVIYTDALQTLIMVIGAVI-----LTIKAFNQIGG---YSNLEEAYLQAVPSKIIpntt 225
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319 238 -----YTWLDNFLLLMLGGIPW------------------QAYFQRVLSSSSATYAQVLSFLAAF------GCLVM---- 284
Cdd:cd11489  226 chlprADAMHLFRDPVTGDLPWtgmtfgltimatwywctdQVIVQRSLSARSLSHAKGGSILASYlkmlpmGLIIMpgmi 305
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319 285 -----------ALPAICIGAIGASTDWNQTAYgypdPKTKEEadmILPIVLQYLCpvyisffgLGAVSAAVMSSADSSIL 353
Cdd:cd11489  306 sralfpddvacVDPEECLRVCGAEVGCSNIAY----PKLVME---LMPSGLRGLM--------IAVMMAALMSSLTSIFN 370
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319 354 SASSMFARNIYQlSFRQNASDKEIVWVMRI-TVLVFGASATAMALLTKTVYGLWYLSSDLVYIIIFPQLLCV----LFIK 428
Cdd:cd11489  371 SSSTLFTMDIWR-RLRPGASERELLLVGRLvTVILVGVSVVWIPILQSSNSGQLYIYIQSVTSYLAPPVTAVfvlaVFWR 449
                        490       500
                 ....*....|....*....|
gi 569001319 429 GTNTYGAVAGYIFGLFLRIT 448
Cdd:cd11489  450 RANEQGAFWGLMAGLVVGLT 469
SLC5sbd_NIS-like cd10326
Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute ...
10-460 3.17e-12

Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute binding domain; NIS (product of the SLC5A5 gene) transports I-, and other anions including ClO4-, SCN-, and Br-. SMVT (product of the SLC5A6 gene) transports biotin, pantothenic acid and lipoate. This subfamily also includes SMCT1 and 2. SMCT1(the product of the SLC5A8 gene) is a high-affinity transporter of various monocarboxylates including lactate and pyruvate, short-chain fatty acids, ketone bodies, nicotinate and its structural analogs, pyroglutamate, benzoate and its derivatives, and iodide. SMCT2 (product of the SLC5A12 gene) is a low-affinity transporter for short-chain fatty acids, lactate, pyruvate, and nicotinate. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271361 [Multi-domain]  Cd Length: 472  Bit Score: 68.74  E-value: 3.17e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319  10 AIILFYLLI-FLVGIWAAWKTKNSgnpeersEAIIVGGRDIGLLVGGFTMTATWVGG-GYINGTAEaVYGPGcgLAWAQA 87
Cdd:cd10326    3 AVVVVYFLIlLAISYYTSRRNADN-------DDFFLGNRQSPWYLVAFSMIGTSLSGvTFVSVPGE-VGGSG--FTYLQM 72
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319  88 PIGYSLSLILGGLFFAKPMRSKGYVTMLDPFQQIYGKRM---GGLLFipaLMGEMFWAAAIFSALGATISVII----DVD 160
Cdd:cd10326   73 VLGFLLGYLIIAFVLLPLYYRLNLTSIYEYLEDRFGVSSrktGAVFF---LLSRILGAGIRLYLVALVLQQFLfdslGIP 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319 161 VNISVIVSALIAILYTLVGGLYSVAYTDVVQLFCIFIGLWISVPFALSHpavTDIGF-TAVHAKYQSPWLGTIesveVYT 239
Cdd:cd10326  150 FWLTVLITGLLIWLYTFRGGIKTVVWTDTLQTVFLLVGLVLTIIIISNS---LGLGFgEAISAAGESGYSRIF----NFD 222
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319 240 WLD---NFLLLMLGGIPW--------QAYFQRVLSSSSATYAQVLSFLAAFGCLVMALPAICIGAIGAStdwnqTAYGYP 308
Cdd:cd10326  223 DDNsrrTFWKQFLGGIFItiamtgldQDMMQRNLSCKNLKDAQKNMLTFGVILVPVNLLFLLLGVLLYT-----YAQKNG 297
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319 309 DPKTKEEADMILP-IVLQYLCPVYISFFGLGAVSAAvMSSADSSILSASSMFARNIYQLSFRQN--ASDKEIVWVMRITV 385
Cdd:cd10326  298 IALPAKDSDQLFPyFALNGLPPGVSGLFVAGIIAAA-MSSADSALTALTTSFCVDILNRFKRKSekKSERKYVHIAFSLT 376
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319 386 LVFGASATAMALLTKTVYGLWYLSSDLVYIIIFPQLLCVLFIKGTNT--YGAVAG-------YIFGLFLRITGGEPYLYL 456
Cdd:cd10326  377 FVLGILVFGSASNSGSLIDAIFKVAGYTYGPLLGLFAFGLFTKRAVKdkWVPLVGllapvlsYLLVSNSEGFFGYKFGFE 456

                 ....
gi 569001319 457 QPLI 460
Cdd:cd10326  457 LLII 460
PRK10484 PRK10484
putative transporter; Provisional
8-449 7.41e-12

putative transporter; Provisional


Pssm-ID: 236699 [Multi-domain]  Cd Length: 523  Bit Score: 67.99  E-value: 7.41e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319   8 LVAIILFYLLIFLVGIWAAWKTKNSGnpEERSEAIIVGGRDIGLLVGGFTMTATWVGGGYINGTAEAVYGPGCG-LAW-A 85
Cdd:PRK10484   1 MLTILSFLGFTLLVAVISWWKTRKTD--TSSSDGYFLAGRSLTGPVIAGSLLLTNLSTEQLVGLNGQAYASGMSvMAWeV 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319  86 QAPIgyslSLILGGLFFAKPMRSKGYVTMLDPFQQIYG---KRMGGLLFIPALMGEMFWAAAIFSALGAT----ISVIID 158
Cdd:PRK10484  79 TAAI----ALIILALIFLPRYLKSGITTIPDFLEERYDkttRRIVSILFLIGYVVSFLPIVLYSGALALNslfhVSELLG 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319 159 VD----VNISVIVSALIAILYTLVGGLYSVAYTDVVQLFCIFIGLWISVPFAL-----------------SHPAvtdiGF 217
Cdd:PRK10484 155 ISygaaIWLLVWLIGIIGAIYAVFGGLKAVAVSDTINGIGLLIGGLLVPVFGLialgdgsfmqgleqlttVHPE----KL 230
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319 218 TAVHAKYQS-PWlGTIES----VEVYTWLDNflllmlggipwQAYFQRVLSSSSATYAQ----VLSFLAAFGCLVMALPa 288
Cdd:PRK10484 231 NSIGGATDPvPF-PTLFTglilVNLFYWCTN-----------QSIVQRALGAKNLAEGQkgalLAAFFKLLGPLILVLP- 297
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319 289 iciGAIGAstdwnqtaYGYPDPKTKeeADMILPIVLQYLCPVYISFFGLGAVSAAVMSSADSSILSASSMFARNIYQLSF 368
Cdd:PRK10484 298 ---GIIAF--------HLYGDGLPN--ADMAYPTLVNDVLPVPLVGFFAAVLFGAILSTFNGFLNSASTLFSLDIYKPII 364
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319 369 RQNASDKEIVWVMRITVLVFGASATAMA-LLTKTVYGLWYLSSDLVYIIIFPQLLCVL---FIKGTNTYGAVAGYIFGLF 444
Cdd:PRK10484 365 NPNASEKQLVKVGKKFGFVLAIISMIVApLIANAPQGLYSYLQQLNGIYNVPILAIIIvgfFTKRVPALAAKVALGFGII 444

                 ....*
gi 569001319 445 LRITG 449
Cdd:PRK10484 445 LYIII 449
SLC5sbd_YidK cd10328
uncharacterized SLC5 subfamily, Escherichia coli YidK-like; solute binding domain; ...
14-445 2.17e-11

uncharacterized SLC5 subfamily, Escherichia coli YidK-like; solute binding domain; Uncharacterized subfamily of the solute binding domain of the solute carrier 5 (SLC5) transporter family (also called the sodium/glucose cotransporter family or solute sodium symporter family) that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily includes the uncharacterized Escherichia coli YidK protein, and belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271362  Cd Length: 472  Bit Score: 66.41  E-value: 2.17e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319  14 FYLLIFLVGIWAAWKTKNSGNpeERSEAIIVGGRDIGLLVGGFTMTATWVGGGYINGTAEAVYGPG-CGLAW-AQAPIGy 91
Cdd:cd10328    1 FLLFTALVALISWYKTRGDDL--SSSDGYFLAGRSLTGVVIAGSLLLTNLSTEQLVGLNGQAYALGmSVMAWeVTAAIA- 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319  92 slsLILGGLFFAKPMRSKGYVTMLDPFQQIYG---KRMGGLLFIPALMGEMFWAAAIFSALGatISVIIDVD-------- 160
Cdd:cd10328   78 ---LIILALVFLPRYLKGGITTIPEFLEERYDettRRIVSILFLLGYVVILLPIVLYSGALA--LNSLFDVSellgisyf 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319 161 --VNISVIVSALIAILYTLVGGLYSVAYTDVVQLFCIFIGlWISVPF----ALSHPAVT---DIGFTAVHAKYQS----- 226
Cdd:cd10328  153 qaLWLLVWLIGIIGAIYAIFGGLKAVAVSDTINGVGLLIG-GLLIPIlgliALGDGSFLaglDTLLTAHPEKLNAiggad 231
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319 227 ---PWlGTIES----VEVYTWLDNflllmlggipwQAYFQRVLSSSSATYAQ----VLSFLAAFGCLVMALPAICigaig 295
Cdd:cd10328  232 spvPF-STLFTgmllVNLFYWCTN-----------QAIIQRALAAKNLKEGQkgvlLAGFFKLLVPLILVLPGII----- 294
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319 296 astdwnqTAYGYPDpkTKEEADMILPIVLQYLCPVYISFFGLGAVSAAVMSSADSSILSASSMFARNIYQLSFRQNASDK 375
Cdd:cd10328  295 -------AFHLYGD--GLENADMAYPTLVADVLPKWLSGFFAAVLFGAILSSFNSALNSAATLFSLDIYKPIINKNATDK 365
                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 569001319 376 EIVWVMRITVLVFGASATAMA-LLTKTVYGLWYL---SSDLVYIIIFPQLLCVLFIKGTNTYGAVAGYIFGLFL 445
Cdd:cd10328  366 QLVKVGKIFGIVLALISMIIApFIAYAPEGLFNYlqqFNGFFSIPILAIVLVGFFTKRVPALAAKIALIFGVIL 439
SLC5sbd_SMIT cd11491
Na(+)/myo-inositol cotransporter SMIT and related proteins; solute-binding domain; Human SMIT ...
8-445 2.12e-09

Na(+)/myo-inositol cotransporter SMIT and related proteins; solute-binding domain; Human SMIT is a high-affinity myo-inositol transporter, and is expressed in brain, heart, kidney, and lung. Inhibition of myo-inositol uptake, through down-regulation of SMIT, may be a common mechanism of action of mood stabilizers, including lithium, carbamazepine, and valproate. SMIT is encoded by the SLC5A3 gene, which is a candidate gene for pathogenesis of nervous system dysfunction in Down syndrome (DS). The SNP, 21q22 near SLC5A3-MRPS6-KCNE2, has been associated with coronary heart disease, cardiovascular disease, and myocardial infarction. SMIT may also be involved in the pathogeneisis of congenital cataract. SMIT also plays roles in osteogenesis, bone formation, and bone mineral density determination. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271382  Cd Length: 609  Bit Score: 60.27  E-value: 2.12e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319   8 LVAIILFYLLIFLVGIWAAWKTKNSgnpeeRSEAIIVGGRDIGLLVGGFTMTATWVGGGYINGTAEAvyGPGCGLAWAQA 87
Cdd:cd11491    2 IAVVALYFILVMCIGIYAMWKSNRS-----TVSGYFLAGRSMTWLPVGASLFASNIGSEHFIGLAGS--GAAAGFAVGAF 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319  88 PIGYSLSLILGGLFFAKPMRSKGYVTMLDPFQQIYG-KRMGGLLFIPALMGEMFWAAAIFSALGAT-ISVIIDVDVNISV 165
Cdd:cd11491   75 EFNALILLQLLGWVFIPVYIRSGVYTLPEYLSKRFGgHRIQVYLAALSLILYIFTKISVNLYSGALfIQEALGWNLYVSI 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319 166 IVSALIAILYTLVGGLYSVAYTDVVQLFCIFIGLWISV---------------PFALSHPAVTDIGFTAVHAKYQS---- 226
Cdd:cd11491  155 ILLLGLTALLTVTGGLAAVIYTDTLQAFLMIIGALTLMiismmeiggfegvksRYMLASPNVTSILLTYNLSNTNSccvh 234
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319 227 -----------------PWLGTI---ESVEVYTWLDNflllmlggipwQAYFQRVLSSSSATYAQVLSFLAAFGCLVMAL 286
Cdd:cd11491  235 pkkdafkllrdptdedvPWPGFIlgqTPASIWYWCAD-----------QVIVQRVLAAKSLSHAQGATLMAGFIKLLPLF 303
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319 287 PAICIGAIGASTDWNQTAYGYPDP------KTKEEADMILPIVLQYLCPVYISFFGLGAVSAAVMSSADSSILSASSMFA 360
Cdd:cd11491  304 IIVIPGMISRILFPDDIACINPEHcmqvcgSRAGCSNIAYPRLVMKIMPSGLRGLMMAVMIAALMSDLTSIFNSASTLFT 383
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319 361 RNIYQLsFRQNASDKEIVWVMRITVLVF-GASATAMALLTKTVYGLWYLSSDLVYIIIFPQL----LCVLFIKGTNTYGA 435
Cdd:cd11491  384 LDVYKL-IRKKASSRELMIVGRIFVAVMvVISIAWIPVIQEMQGGQLYLYIQEVAAYLTPPVaslyLLAIFWKRTTEQGA 462
                        490
                 ....*....|
gi 569001319 436 VAGYIFGLFL 445
Cdd:cd11491  463 FYGGMAGFVL 472
SLC5sbd_NIS-SMVT cd11492
Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute ...
152-464 1.38e-06

Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute binding domain; NIS (encoded by the SLC5A5 gene) transports I-, and other anions including ClO4-, SCN-, and Br-. SMVT (encoded by the SLC5A6 gene) transports biotin, pantothenic acid and lipoate. This subfamily also includes SMCT1 and -2. SMCT1(encoded by the SLC5A8 gene) is a high-affinity transporter of various monocarboxylates including lactate and pyruvate, short-chain fatty acids, ketone bodies, nicotinate and its structural analogs, pyroglutamate, benzoate and its derivatives, and iodide. SMCT2 (encoded by the SLC5A12 gene) is a low-affinity transporter for short-chain fatty acids, lactate, pyruvate, and nicotinate. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271383 [Multi-domain]  Cd Length: 522  Bit Score: 50.95  E-value: 1.38e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319 152 TISVIIDVDVNISVIVSALIAILYTLVGGLYSVAYTDVVQLFCIFIGLWISVPFALSHPavtdIGFTAVhakyqspWLGT 231
Cdd:cd11492  141 ALSQVTGINLHIIILVVGIVCIFYTTLGGLKAVVWTDVFQVVVMFGGVLAVIILGTIDV----GGFSEV-------WEIA 209
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319 232 IES--VEVYTW-LD-----NFLLLMLGG-IPW-------QAYFQRVLSSSSATYAQVLSFLAAFGCLVMALPAICIGAIG 295
Cdd:cd11492  210 EEGgrLEFFNFdPDptvrhTFWSLVIGGtFTWlslygvnQTQVQRYLSLPSLKSAKKALWLNIVGLILILSLCCFTGLVI 289
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319 296 ASTdwnqtaYGYPDPKTK---EEADMILPIVLQYLCPVYISFFGL---GAVSAAvMSSADSSILSASSMFARNIYQLSFR 369
Cdd:cd11492  290 YAK------YHDCDPLTAgliKKPDQLLPYFVMDVLGHLPGLPGLfvaGIFSAA-LSTLSSGLNSLAAVILEDFIKPFFK 362
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319 370 QNASDKEIVWVMRITVLVFGASATAMALLTKTVYGLWYLSSDLVYIIIFPqLLCV----LFIKGTNTYGAVAGYIFGLF- 444
Cdd:cd11492  363 KKLSERQATNIMKLLVVVFGLLCIGLAFLVEKLGGVLQLSLSIFGITGGP-LLGIftlgMFFPWANSKGALVGLLVGLIf 441
                        330       340
                 ....*....|....*....|.
gi 569001319 445 -LRITGGEPYLYLQPLIFYPG 464
Cdd:cd11492  442 mLWIGIGGQIAIAPGPLSFPP 462
SLC5sbd_SMVT cd11504
Na(+)/multivitamin cotransporter SMVT and related proteins; solute-binding domain; This ...
100-445 4.88e-05

Na(+)/multivitamin cotransporter SMVT and related proteins; solute-binding domain; This multivitamin transporter SMVT (product of the SLC5A6 gene) transports biotin, pantothenic acid and lipoate, and is essential for mediating biotin uptake into mammalian cells. SMVT is expressed in the placenta, intestine, heart, brain, lung, liver, kidney and pancreas. Biotin may regulate its own cellular uptake through participation in holocarboxylase synthetase-dependent chromatin remodeling events at SMVT promoter loci. The cis regulatory elements, Kruppel-like factor 4 and activator protein-2, regulate the activity of the human SMVT promoter in the intestine. Glycosylation of the hSMVT is important for its transport function. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271394 [Multi-domain]  Cd Length: 527  Bit Score: 46.02  E-value: 4.88e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319 100 LFFAKPMRSKGYVTMLdpFQQIYgkRMGGLLFIPALmgemfwaaaifsalgaTISVIIDVDVNISVIVSALIAILYTLVG 179
Cdd:cd11504  112 LRFNKTVRICGTVTFI--FQMVI--YMGVVLYAPAL----------------ALNAVTGFNLWISVLAMGVVCTFYTALG 171
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319 180 GLYSVAYTDVVQLFCIFIG-LWISVPFALSHPAVTDIGFTAVHAKYQSPWLGTIESVEVYT-WL----DNFLLLMLGGIP 253
Cdd:cd11504  172 GLKAVIWTDVFQTVVMFAGqLAVIIVGSIEAGGIARVWRVAAESDRIDGFNLSPDPTIRHTfWTlvvgGVFNMLALYGVN 251
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319 254 wQAYFQRVLSSSSATYAqVLSFLAAFGCLVMALPAIC-IGAIGASTdwnqtaYGYPDPKTKEEADMILPIVLQYLCPVYI 332
Cdd:cd11504  252 -QAQVQRYLSSRTEKQA-KRSCYLVFPGQQLSLCIGClCGLVMFAR------YHECDPLKNGIVARSDQLVPYFVMDVLD 323
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319 333 SFFGL-GAVSAAVMSSADSSILSASSMFA----RNIYQLSFRqNASDKEIVWVMRITVLVFGASATAMALLTKTVYGLWY 407
Cdd:cd11504  324 GLPGLpGLFIACLFSGALSTISSAFNSLAtvtmEDLIVPKFP-DMTEERATLLSKGLAVGYGLLCLLMAYLASTMGQVLQ 402
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|.
gi 569001319 408 LSSDLVYIIIFP--QLLCV-LFIKGTNTYGAVAGYIFGLFL 445
Cdd:cd11504  403 AANSIFGMIGGPllGLFCLgMFFPCANSAGAVVGLLAGLFM 443
SLC5sbd_NIS cd11503
Na(+)/iodide cotransporter NIS and related proteins; solute-binding domain; NIS (product of ...
21-201 1.97e-03

Na(+)/iodide cotransporter NIS and related proteins; solute-binding domain; NIS (product of the SLC5A5 gene) transports I-, and other anions including ClO4-, SCN-, and Br-. NIS is expressed in the thyroid, colon, ovary, and in human breast cancers. It mediates the active transport and the concentration of iodide from the blood into thyroid follicular cells, a fundamental step in thyroid hormone biosynthesis, and is the basis of radioiodine therapy for thyroid cancer. Mutation in the SLC5A5 gene can result in a form of thyroid hormone dysgenesis. Human NIS exists mainly as a dimer stabilized by a disulfide bridge. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271393  Cd Length: 535  Bit Score: 40.98  E-value: 1.97e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319  21 VGIWAAWKTKNsgnpEERSEAIIVGGRDIGLLVGGFTMTATWVGGGYINGTAEAVYGpgCGLAWAQAPIGYSLSLILGGL 100
Cdd:cd11503   16 IGLFVGLARGG----QRSADDFFTGGRGLSAVPVGLSLSASFMSAVQVLGVPSEAYR--YGLKFLWMCLGQLLNSLMTAV 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319 101 FFAKPMRSKGYVTMLDPFQQIYGKRMGGLLFIPALMGEMFWAAAIFSALGATISVIIDVDVNISVIVSALIAILYTLVGG 180
Cdd:cd11503   90 LFMPVFYRLGITSTYQYLEMRFSRAVRLCGTLQFIVATMLYTGIVIYAPALILNQVTGLDIWASLFSTGIICTFYTTVGG 169
                        170       180
                 ....*....|....*....|.
gi 569001319 181 LYSVAYTDVVQLFCIFIGLWI 201
Cdd:cd11503  170 MKAVIWTDVFQVVVMLSGFWA 190
SLC5sbd_SMCT cd11505
Na(+)/monocarboxylate cotransporters SMCT1 and 2 and related proteins; solute-binding domain; ...
2-405 7.76e-03

Na(+)/monocarboxylate cotransporters SMCT1 and 2 and related proteins; solute-binding domain; SMCT1 is a high-affinity transporter of various monocarboxylates including lactate and pyruvate, short-chain fatty acids, ketone bodies, nicotinate and its structural analogs, pyroglutamate, benzoate and its derivatives, and iodide. Human SMCT1 (hSMCT1, also called AIT) is encoded by the tumor suppressor gene SLC5A8. SMCT1 is expressed in the colon, small intestine, kidney, thyroid gland, retina, and brain. SMCT1 may contribute to the intestinal/colonic and oral absorption of monocarboxylate drugs. It also mediates iodide transport from thyrocyte into the colloid lumen in thyroid gland and, through transporting L-lactate and ketone bodies, helps maintain the energy status and the function of neurons. SMCT2 is a low-affinity transporter for short-chain fatty acids, lactate, pyruvate, and nicotinate. hSMCT2 is encoded by the SLC5A12 gene. SMCT2 is expressed in the kidney, small intestine, skeletal muscle, and retina. In the kidney, SMCT2 may initiate lactate absorption in the early parts of the tubule, SMCT1 in the latter parts of the tubule. In the retina, SMCT1 and SMCT2 may play a differential role in monocarboxylate transport in a cell type-specific manner. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271395  Cd Length: 538  Bit Score: 39.10  E-value: 7.76e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319   2 SFHVEGLVAIILFYLLIFLVGIWAAWKtknsGNPEERSEAIIVGGRDIGLLVGGFTMTATWVGGGYINGTAEAVYGpgCG 81
Cdd:cd11505    3 NFAVWDYVVFAAMLFISAGIGIYYAFA----GGGQATSKDFLMGGRQMTAVPVALSLTASFMSAVTVLGTPSEVYR--FG 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319  82 LAWAQAPIGYSLSLILGGLFFAKPMRSKGYVTMLDPFQQIYGKRMGGLLFIPALMGEMFWAAAIFSALGATISVIIDVDV 161
Cdd:cd11505   77 ASFLIFAFAYLFVVLISSEVFLPVFYRLGITSTYEYLELRFNKPVRLAGTVLFIVQTILYTGIVIYAPALALNQVTGFDL 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319 162 NISVIVSALIAILYTLVGGLYSVAYTDVVQLFCIFIGLWISVPFALSHP-AVTDIGFTAVHAKYQSPWLGTIESVEVYTw 240
Cdd:cd11505  157 WGAVVATGVVCTFYCTLGGLKAVVWTDVFQVGIMVAGFLSVIIQAVVHQgGIHNILNDSYNGSRLNFWDFDPNPLRRHT- 235
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319 241 ldnFLLLMLGG-IPW-------QAYFQRVLSSSSATYAQVLSFLAAFGCLVMALPAICIGAIGASTdwnqtaYGYPDPKT 312
Cdd:cd11505  236 ---FWTITVGGtFTWtgiygvnQSQVQRYISCKTRFQAKLSLYFNLLGLWAILVCAVFSGLAMYSH------YKDCDPWT 306
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001319 313 KE---EADMILPIVLQYLCPVYISFFGLGAVSA--AVMSSADSSILSASSMFARNIYQLSFRqNASDKEIVWVMRITVLV 387
Cdd:cd11505  307 AKivsAPDQLMPYLVLDILADYPGLPGLFVACAysGTLSTVSSSINALAAVTVEDLIKPYFR-SLSEKLSSWISKGLSLL 385
                        410
                 ....*....|....*...
gi 569001319 388 FGASATAMALLTKTVYGL 405
Cdd:cd11505  386 YGAMCIGMAVAASLMGGL 403
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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