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Conserved domains on  [gi|569004266|ref|XP_006526193|]
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elongator complex protein 2 isoform X1 [Mus musculus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
17-386 5.89e-21

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 94.98  E-value: 5.89e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004266  17 WLEQVRVGEVGGNTLGFYDCQFGENGTMIIAHAFHGALHLWKQSTVNPRQwapeiVISGHFDGVQDLMWDPEGEFIITTS 96
Cdd:COG2319   65 AAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLR-----TLTGHTGAVRSVAFSPDGKTLASGS 139

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004266  97 TDQTTRLfapWKKKDQKdrsqvtwhEIARPQIHGYNIKCLAmidrF-----QFVSGADEKVLRVFsaprnfvenfsvisr 171
Cdd:COG2319  140 ADGTVRL---WDLATGK--------LLRTLTGHSGAVTSVA----FspdgkLLASGSDDGTVRLW--------------- 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004266 172 qslshmlcddqDLPEGATVPALGLSNKALFqgDIAsqpfeedelISP-----AFGSpqvtfqpavlnepptEDHLLQntL 246
Cdd:COG2319  190 -----------DLATGKLLRTLTGHTGAVR--SVA---------FSPdgkllASGS---------------ADGTVR--L 230

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004266 247 W-----PEIQKLYGHGYEIVCVACNNSKTLLASACkasqkEHAAIILWSTASWKQVQSLAFHTLTVTQMTFSPDDKFLLA 321
Cdd:COG2319  231 WdlatgKLLRTLTGHSGSVRSVAFSPDGRLLASGS-----ADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLAS 305

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 569004266 322 VSRDRTWSLWkrqDATSSEfdpffSLFAFTNkitsvHSRIIWSCDWSPDNKYFFTGSRDKKVVVW 386
Cdd:COG2319  306 GSDDGTVRLW---DLATGK-----LLRTLTG-----HTGAVRSVAFSPDGKTLASGSDDGTVRLW 357
WD40 COG2319
WD40 repeat [General function prediction only];
278-521 7.98e-11

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 63.78  E-value: 7.98e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004266 278 ASQKEHAAIILWSTASWKQVQSLAFHTLTVTQMTFSPDDKFLLAVSRDRTWSLWkrqDATSSEFDPFFSLfaftnkitsv 357
Cdd:COG2319   52 AAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLW---DLATGLLLRTLTG---------- 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004266 358 HSRIIWSCDWSPDNKYFFTGSRDKKVVVW----GECksSHNPMEHPirpcssildvgSSVTAVSVcpvlNPAQRYIVAiG 433
Cdd:COG2319  119 HTGAVRSVAFSPDGKTLASGSADGTVRLWdlatGKL--LRTLTGHS-----------GAVTSVAF----SPDGKLLAS-G 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004266 434 LESGKICIYSWnKTNQEINDWTscvetnpsqSHSLGIRRLCWkscsddddddddddteqSEEGpEWLhfASCGEDHTVKI 513
Cdd:COG2319  181 SDDGTVRLWDL-ATGKLLRTLT---------GHTGAVRSVAF-----------------SPDG-KLL--ASGSADGTVRL 230


                 ....*...
gi 569004266 514 YRVNRRAL 521
Cdd:COG2319  231 WDLATGKL 238
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
17-386 5.89e-21

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 94.98  E-value: 5.89e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004266  17 WLEQVRVGEVGGNTLGFYDCQFGENGTMIIAHAFHGALHLWKQSTVNPRQwapeiVISGHFDGVQDLMWDPEGEFIITTS 96
Cdd:COG2319   65 AAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLR-----TLTGHTGAVRSVAFSPDGKTLASGS 139

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004266  97 TDQTTRLfapWKKKDQKdrsqvtwhEIARPQIHGYNIKCLAmidrF-----QFVSGADEKVLRVFsaprnfvenfsvisr 171
Cdd:COG2319  140 ADGTVRL---WDLATGK--------LLRTLTGHSGAVTSVA----FspdgkLLASGSDDGTVRLW--------------- 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004266 172 qslshmlcddqDLPEGATVPALGLSNKALFqgDIAsqpfeedelISP-----AFGSpqvtfqpavlnepptEDHLLQntL 246
Cdd:COG2319  190 -----------DLATGKLLRTLTGHTGAVR--SVA---------FSPdgkllASGS---------------ADGTVR--L 230

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004266 247 W-----PEIQKLYGHGYEIVCVACNNSKTLLASACkasqkEHAAIILWSTASWKQVQSLAFHTLTVTQMTFSPDDKFLLA 321
Cdd:COG2319  231 WdlatgKLLRTLTGHSGSVRSVAFSPDGRLLASGS-----ADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLAS 305

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 569004266 322 VSRDRTWSLWkrqDATSSEfdpffSLFAFTNkitsvHSRIIWSCDWSPDNKYFFTGSRDKKVVVW 386
Cdd:COG2319  306 GSDDGTVRLW---DLATGK-----LLRTLTG-----HTGAVRSVAFSPDGKTLASGSDDGTVRLW 357
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 249-515 1.19e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 83.54  E-value: 1.19e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004266 249 EIQKLYGHGYEIVCVACNNSKTLLASAckasqKEHAAIILWSTASWKQVQSLAFHTLTVTQMTFSPDDKFLLAVSRDRTW 328
Cdd:cd00200   85 CVRTLTGHTSYVSSVAFSPDGRILSSS-----SRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTI 159

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004266 329 SLWkrqDATSSEFDPFFSLfaftnkitsvHSRIIWSCDWSPDNKYFFTGSRDKKVVVW----GECKSSHNPMEHPirpcs 404
Cdd:cd00200  160 KLW---DLRTGKCVATLTG----------HTGEVNSVAFSPDGEKLLSSSSDGTIKLWdlstGKCLGTLRGHENG----- 221

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004266 405 sildvgssVTAVSVCPvlnpaQRYIVAIGLESGKICIYswnktnqeinDWTSCVETNPSQSHSLGIRRLCWkscsddddd 484
Cdd:cd00200  222 --------VNSVAFSP-----DGYLLASGSEDGTIRVW----------DLRTGECVQTLSGHTNSVTSLAW--------- 269

                        250       260       270
                 ....*....|....*....|....*....|.
gi 569004266 485 dddddteqSEEGPewlHFASCGEDHTVKIYR 515
Cdd:cd00200  270 --------SPDGK---RLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
278-521 7.98e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 63.78  E-value: 7.98e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004266 278 ASQKEHAAIILWSTASWKQVQSLAFHTLTVTQMTFSPDDKFLLAVSRDRTWSLWkrqDATSSEFDPFFSLfaftnkitsv 357
Cdd:COG2319   52 AAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLW---DLATGLLLRTLTG---------- 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004266 358 HSRIIWSCDWSPDNKYFFTGSRDKKVVVW----GECksSHNPMEHPirpcssildvgSSVTAVSVcpvlNPAQRYIVAiG 433
Cdd:COG2319  119 HTGAVRSVAFSPDGKTLASGSADGTVRLWdlatGKL--LRTLTGHS-----------GAVTSVAF----SPDGKLLAS-G 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004266 434 LESGKICIYSWnKTNQEINDWTscvetnpsqSHSLGIRRLCWkscsddddddddddteqSEEGpEWLhfASCGEDHTVKI 513
Cdd:COG2319  181 SDDGTVRLWDL-ATGKLLRTLT---------GHTGAVRSVAF-----------------SPDG-KLL--ASGSADGTVRL 230


                 ....*...
gi 569004266 514 YRVNRRAL 521
Cdd:COG2319  231 WDLATGKL 238
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 358-386 7.19e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.07  E-value: 7.19e-06
                           10        20
                   ....*....|....*....|....*....
gi 569004266   358 HSRIIWSCDWSPDNKYFFTGSRDKKVVVW 386
Cdd:smart00320  11 HTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
358-386 1.16e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.33  E-value: 1.16e-05
                          10        20
                  ....*....|....*....|....*....
gi 569004266  358 HSRIIWSCDWSPDNKYFFTGSRDKKVVVW 386
Cdd:pfam00400  10 HTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
17-386 5.89e-21

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 94.98  E-value: 5.89e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004266  17 WLEQVRVGEVGGNTLGFYDCQFGENGTMIIAHAFHGALHLWKQSTVNPRQwapeiVISGHFDGVQDLMWDPEGEFIITTS 96
Cdd:COG2319   65 AAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLR-----TLTGHTGAVRSVAFSPDGKTLASGS 139

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004266  97 TDQTTRLfapWKKKDQKdrsqvtwhEIARPQIHGYNIKCLAmidrF-----QFVSGADEKVLRVFsaprnfvenfsvisr 171
Cdd:COG2319  140 ADGTVRL---WDLATGK--------LLRTLTGHSGAVTSVA----FspdgkLLASGSDDGTVRLW--------------- 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004266 172 qslshmlcddqDLPEGATVPALGLSNKALFqgDIAsqpfeedelISP-----AFGSpqvtfqpavlnepptEDHLLQntL 246
Cdd:COG2319  190 -----------DLATGKLLRTLTGHTGAVR--SVA---------FSPdgkllASGS---------------ADGTVR--L 230

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004266 247 W-----PEIQKLYGHGYEIVCVACNNSKTLLASACkasqkEHAAIILWSTASWKQVQSLAFHTLTVTQMTFSPDDKFLLA 321
Cdd:COG2319  231 WdlatgKLLRTLTGHSGSVRSVAFSPDGRLLASGS-----ADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLAS 305

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 569004266 322 VSRDRTWSLWkrqDATSSEfdpffSLFAFTNkitsvHSRIIWSCDWSPDNKYFFTGSRDKKVVVW 386
Cdd:COG2319  306 GSDDGTVRLW---DLATGK-----LLRTLTG-----HTGAVRSVAFSPDGKTLASGSDDGTVRLW 357
WD40 COG2319
WD40 repeat [General function prediction only];
2-386 1.97e-20

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 93.44  E-value: 1.97e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004266   2 DKTMILWapDEESGVWLEQVRvgevgGNTLGFYDCQFGENGTMIIAHAFHGALHLWkqstvNPRQWAPEIVISGHFDGVQ 81
Cdd:COG2319   99 DGTVRLW--DLATGLLLRTLT-----GHTGAVRSVAFSPDGKTLASGSADGTVRLW-----DLATGKLLRTLTGHSGAVT 166

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004266  82 DLMWDPEGEFIITTSTDQTTRLfapWKKKDQKdrsqvtwhEIARPQIHGYNIKCLAMI-DRFQFVSGADEKVLRVFSAPR 160
Cdd:COG2319  167 SVAFSPDGKLLASGSDDGTVRL---WDLATGK--------LLRTLTGHTGAVRSVAFSpDGKLLASGSADGTVRLWDLAT 235

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004266 161 NFVenfsvisRQSLSHmlcddqdlpEGATVPALGLSNkalfQGDIAsqpfeedelispAFGSpqvtfqpavlnepptEDH 240
Cdd:COG2319  236 GKL-------LRTLTG---------HSGSVRSVAFSP----DGRLL------------ASGS---------------ADG 268

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004266 241 LLQntLW-----PEIQKLYGHGYEIVCVACNNSKTLLASACkasqkEHAAIILWSTASWKQVQSLAFHTLTVTQMTFSPD 315
Cdd:COG2319  269 TVR--LWdlatgELLRTLTGHSGGVNSVAFSPDGKLLASGS-----DDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPD 341

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 569004266 316 DKFLLAVSRDRTWSLWKRQDATssefdpffSLFAFTNkitsvHSRIIWSCDWSPDNKYFFTGSRDKKVVVW 386
Cdd:COG2319  342 GKTLASGSDDGTVRLWDLATGE--------LLRTLTG-----HTGAVTSVAFSPDGRTLASGSADGTVRLW 399
WD40 COG2319
WD40 repeat [General function prediction only];
246-517 1.29e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 88.04  E-value: 1.29e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004266 246 LW-----PEIQKLYGHGYEIVCVACNNSKTLLASACkasqkEHAAIILWSTASWKQVQSLAFHTLTVTQMTFSPDDKFLL 320
Cdd:COG2319  188 LWdlatgKLLRTLTGHTGAVRSVAFSPDGKLLASGS-----ADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLA 262

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004266 321 AVSRDRTWSLWkrqDATSSEFDPFFslfaftnkitSVHSRIIWSCDWSPDNKYFFTGSRDKKVVVW----GECKSSHNPM 396
Cdd:COG2319  263 SGSADGTVRLW---DLATGELLRTL----------TGHSGGVNSVAFSPDGKLLASGSDDGTVRLWdlatGKLLRTLTGH 329

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004266 397 EHPIRpcssildvgsSVtAVSvcpvlnPAQRYIVAiGLESGKICIysWNKTNQEindwtscvETNPSQSHSLGIRRLCWk 476
Cdd:COG2319  330 TGAVR----------SV-AFS------PDGKTLAS-GSDDGTVRL--WDLATGE--------LLRTLTGHTGAVTSVAF- 380

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 569004266 477 scsddddddddddteqSEEGPewlHFASCGEDHTVKIYRVN 517
Cdd:COG2319  381 ----------------SPDGR---TLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
246-521 2.87e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 86.89  E-value: 2.87e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004266 246 LW-----PEIQKLYGHGYEIVCVACNNSKTLLASACKASQkehaaIILWSTASWKQVQSLAFHTLTVTQMTFSPDDKFLL 320
Cdd:COG2319  146 LWdlatgKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGT-----VRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLA 220

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004266 321 AVSRDRTWSLWkrqDATSSEFdpffsLFAFTNkitsvHSRIIWSCDWSPDNKYFFTGSRDKKVVVW----GECKSShnpM 396
Cdd:COG2319  221 SGSADGTVRLW---DLATGKL-----LRTLTG-----HSGSVRSVAFSPDGRLLASGSADGTVRLWdlatGELLRT---L 284

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004266 397 EHPirpcssildvGSSVTAVSVCPvlnpaQRYIVAIGLESGKICIYSWnKTNQEINDWTScvetnpsqsHSLGIRRLCWk 476
Cdd:COG2319  285 TGH----------SGGVNSVAFSP-----DGKLLASGSDDGTVRLWDL-ATGKLLRTLTG---------HTGAVRSVAF- 338

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 569004266 477 scsddddddddddteqSEEGpEWLhfASCGEDHTVKIYRVNRRAL 521
Cdd:COG2319  339 ----------------SPDG-KTL--ASGSDDGTVRLWDLATGEL 364
WD40 COG2319
WD40 repeat [General function prediction only];
249-521 4.14e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 86.50  E-value: 4.14e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004266 249 EIQKLYGHGYEIVCVACNNSKTLLASACkasqkEHAAIILWSTASWKQVQSLAFHTLTVTQMTFSPDDKFLLAVSRDRTW 328
Cdd:COG2319  112 LLRTLTGHTGAVRSVAFSPDGKTLASGS-----ADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTV 186

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004266 329 SLWkrqDATSSEFdpffsLFAFTNkitsvHSRIIWSCDWSPDNKYFFTGSRDKKVVVW----GECKSshnPMEHPirpcs 404
Cdd:COG2319  187 RLW---DLATGKL-----LRTLTG-----HTGAVRSVAFSPDGKLLASGSADGTVRLWdlatGKLLR---TLTGH----- 245

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004266 405 sildvGSSVTAVSVCPvlnpaQRYIVAIGLESGKICIYSWNkTNQEINDWTscvetnpsqSHSLGIRRLCWkscsddddd 484
Cdd:COG2319  246 -----SGSVRSVAFSP-----DGRLLASGSADGTVRLWDLA-TGELLRTLT---------GHSGGVNSVAF--------- 296

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 569004266 485 dddddteqSEEGpEWLhfASCGEDHTVKIYRVNRRAL 521
Cdd:COG2319  297 --------SPDG-KLL--ASGSDDGTVRLWDLATGKL 322
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 249-515 1.19e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 83.54  E-value: 1.19e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004266 249 EIQKLYGHGYEIVCVACNNSKTLLASAckasqKEHAAIILWSTASWKQVQSLAFHTLTVTQMTFSPDDKFLLAVSRDRTW 328
Cdd:cd00200   85 CVRTLTGHTSYVSSVAFSPDGRILSSS-----SRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTI 159

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004266 329 SLWkrqDATSSEFDPFFSLfaftnkitsvHSRIIWSCDWSPDNKYFFTGSRDKKVVVW----GECKSSHNPMEHPirpcs 404
Cdd:cd00200  160 KLW---DLRTGKCVATLTG----------HTGEVNSVAFSPDGEKLLSSSSDGTIKLWdlstGKCLGTLRGHENG----- 221

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004266 405 sildvgssVTAVSVCPvlnpaQRYIVAIGLESGKICIYswnktnqeinDWTSCVETNPSQSHSLGIRRLCWkscsddddd 484
Cdd:cd00200  222 --------VNSVAFSP-----DGYLLASGSEDGTIRVW----------DLRTGECVQTLSGHTNSVTSLAW--------- 269

                        250       260       270
                 ....*....|....*....|....*....|.
gi 569004266 485 dddddteqSEEGPewlHFASCGEDHTVKIYR 515
Cdd:cd00200  270 --------SPDGK---RLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 249-514 3.28e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 78.92  E-value: 3.28e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004266 249 EIQKLYGHGYEIVCVACNNSKTLLASACkasqkEHAAIILWSTASWKQVQSLAFHTLTVTQMTFSPDDKFLLAVSRDRTW 328
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGS-----GDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTI 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004266 329 SLWKRQdatssefdpffslfafTNKITSV---HSRIIWSCDWSPDNKYFFTGSRDKKVVVW----GECksshnpmehpir 401
Cdd:cd00200   76 RLWDLE----------------TGECVRTltgHTSYVSSVAFSPDGRILSSSSRDKTIKVWdvetGKC------------ 127

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004266 402 pCSSILDVGSSVTAVSVcpvlNPAQRYIVAIGLESgkiCIYSWNKTNQeindwtSCVETNPsqSHSLGIRRLCWKscsdd 481
Cdd:cd00200  128 -LTTLRGHTDWVNSVAF----SPDGTFVASSSQDG---TIKLWDLRTG------KCVATLT--GHTGEVNSVAFS----- 186

                        250       260       270
                 ....*....|....*....|....*....|...
gi 569004266 482 ddddddddteqseegPEWLHFASCGEDHTVKIY 514
Cdd:cd00200  187 ---------------PDGEKLLSSSSDGTIKLW 204
WD40 COG2319
WD40 repeat [General function prediction only];
241-521 1.38e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 75.72  E-value: 1.38e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004266 241 LLQNTLWPEIQKLYGHGYEIVCVACNNSKTLLASACkasqkEHAAIILWSTASWKQVQSLAFHTLTVTQMTFSPDDKFLL 320
Cdd:COG2319   62 LLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASAS-----ADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLA 136

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004266 321 AVSRDRTWSLWkrqDATSSEFdpffsLFAFTNkitsvHSRIIWSCDWSPDNKYFFTGSRDKKVVVW----GECksshnpm 396
Cdd:COG2319  137 SGSADGTVRLW---DLATGKL-----LRTLTG-----HSGAVTSVAFSPDGKLLASGSDDGTVRLWdlatGKL------- 196

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004266 397 ehpIRpcsSILDVGSSVTAVSVcpvlNPAQRYIvAIGLESGKICIYSWnKTNQEINDWTscvetnpsqSHSLGIRRLCWk 476
Cdd:COG2319  197 ---LR---TLTGHTGAVRSVAF----SPDGKLL-ASGSADGTVRLWDL-ATGKLLRTLT---------GHSGSVRSVAF- 254

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 569004266 477 scsddddddddddteqSEEGPewlHFASCGEDHTVKIYRVNRRAL 521
Cdd:COG2319  255 ----------------SPDGR---LLASGSADGTVRLWDLATGEL 280
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 34-386 2.95e-14

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 73.14  E-value: 2.95e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004266  34 YDCQFGENGTMIIAHAFHGALHLWKQSTVnprqwAPEIVISGHFDGVQDLMWDPEGEFIITTSTDQTTRLfapWKKKDQK 113
Cdd:cd00200   13 TCVAFSPDGKLLATGSGDGTIKVWDLETG-----ELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRL---WDLETGE 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004266 114 DRSQVTWHEIArpqihgynIKCLAMIDRFQFVSGA-DEKVLRVFsaprnfvenfsvisrqslshmlcddqDLPEGATVPA 192
Cdd:cd00200   85 CVRTLTGHTSY--------VSSVAFSPDGRILSSSsRDKTIKVW--------------------------DVETGKCLTT 130

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004266 193 LGlsnkaLFQGDIASQPFEEDELIspAFGSPQvtfqpavlneppteDHLLqnTLW-----PEIQKLYGHGYEIVCVACNN 267
Cdd:cd00200  131 LR-----GHTDWVNSVAFSPDGTF--VASSSQ--------------DGTI--KLWdlrtgKCVATLTGHTGEVNSVAFSP 187

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004266 268 SKTLLASACKASQkehaaIILWSTASWKQVQSLAFHTLTVTQMTFSPDDKFLLAVSRDRT---WSLWKRQdatssefdpf 344
Cdd:cd00200  188 DGEKLLSSSSDGT-----IKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTirvWDLRTGE---------- 252

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|..
gi 569004266 345 fslfafTNKITSVHSRIIWSCDWSPDNKYFFTGSRDKKVVVW 386
Cdd:cd00200  253 ------CVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
278-521 7.98e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 63.78  E-value: 7.98e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004266 278 ASQKEHAAIILWSTASWKQVQSLAFHTLTVTQMTFSPDDKFLLAVSRDRTWSLWkrqDATSSEFDPFFSLfaftnkitsv 357
Cdd:COG2319   52 AAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLW---DLATGLLLRTLTG---------- 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004266 358 HSRIIWSCDWSPDNKYFFTGSRDKKVVVW----GECksSHNPMEHPirpcssildvgSSVTAVSVcpvlNPAQRYIVAiG 433
Cdd:COG2319  119 HTGAVRSVAFSPDGKTLASGSADGTVRLWdlatGKL--LRTLTGHS-----------GAVTSVAF----SPDGKLLAS-G 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004266 434 LESGKICIYSWnKTNQEINDWTscvetnpsqSHSLGIRRLCWkscsddddddddddteqSEEGpEWLhfASCGEDHTVKI 513
Cdd:COG2319  181 SDDGTVRLWDL-ATGKLLRTLT---------GHTGAVRSVAF-----------------SPDG-KLL--ASGSADGTVRL 230


                 ....*...
gi 569004266 514 YRVNRRAL 521
Cdd:COG2319  231 WDLATGKL 238
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 2-105 1.18e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 50.41  E-value: 1.18e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004266   2 DKTMILWapDEESGVWLEQVRvgevgGNTLGFYDCQFGENGTMIIAHAFHGALHLWKQSTVNPRQwapeiVISGHFDGVQ 81
Cdd:cd00200  198 DGTIKLW--DLSTGKCLGTLR-----GHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQ-----TLSGHTNSVT 265

                         90       100
                 ....*....|....*....|....
gi 569004266  82 DLMWDPEGEFIITTSTDQTTRLFA 105
Cdd:cd00200  266 SLAWSPDGKRLASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 358-386 7.19e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.07  E-value: 7.19e-06
                           10        20
                   ....*....|....*....|....*....
gi 569004266   358 HSRIIWSCDWSPDNKYFFTGSRDKKVVVW 386
Cdd:smart00320  11 HTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
358-386 1.16e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.33  E-value: 1.16e-05
                          10        20
                  ....*....|....*....|....*....
gi 569004266  358 HSRIIWSCDWSPDNKYFFTGSRDKKVVVW 386
Cdd:pfam00400  10 HTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 293-332 2.48e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.53  E-value: 2.48e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 569004266   293 SWKQVQSLAFHTLTVTQMTFSPDDKFLLAVSRDRTWSLWK 332
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
294-331 2.69e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.48  E-value: 2.69e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 569004266  294 WKQVQSLAFHTLTVTQMTFSPDDKFLLAVSRDRTWSLW 331
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 pfam00400
WD domain, G-beta repeat;
67-104 7.57e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 34.24  E-value: 7.57e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 569004266   67 WAPEIVISGHFDGVQDLMWDPEGEFIITTSTDQTTRLF 104
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 66-104 9.74e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.21  E-value: 9.74e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 569004266    66 QWAPEIVISGHFDGVQDLMWDPEGEFIITTSTDQTTRLF 104
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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