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Conserved domains on  [gi|569011005|ref|XP_006528455|]
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protocadherin-11 X-linked isoform X6 [Mus musculus]

Protein Classification

protocadherin( domain architecture ID 13228256)

protocadherin is a transmembrane protein belonging to the cadherin superfamily and may be a calcium-dependent cell-adhesion protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Protocadherin pfam08374
Protocadherin; The structure of protocadherins is similar to that of classic cadherins ...
 805-1007 1.71e-89

Protocadherin; The structure of protocadherins is similar to that of classic cadherins (pfam00028), but particularly on the cytoplasmic domains they also have some unique features. They are expressed in a variety of organizms and are found in high concentrations in the brain where they seem to be localized mainly at cell-cell contact sites. Their expression seems to be developmentally regulated.


:

Pssm-ID: 462451  Cd Length: 217  Bit Score: 285.87  E-value: 1.71e-89
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011005   805 SVPNATLIYELVRRSIDAPANQNT-ETTSASSPTTDYVKIMVAIVAGTITVVLVIFITAVVR-CRQP--PHLKASQKnkQ 880
Cdd:pfam08374    1 SLANATLVEELVRRSLETPLDRDIaGDPDYSSLGKDYLKILIAILAGAMTVILVIFIVVLVRyCRQKekPGYKAGKK--Q 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011005   881 NSEWVTPNPENRQMIMMKKKKKKKKKHP--PKNLLLNFVTIEEAKPDDGENERNSVTLDLPIeleeqtmgkynwgTTPTT 958
Cdd:pfam08374   79 NSDWVTPNPENKQMKGKKKKKKKRPKPAklPKSLLLNLVTIEESKPDDVENEGDSPRIDLPI-------------TLPTT 145

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|.
gi 569011005   959 FKPDSPDLARHYKSASPQPAFQIQPETPLN-SKHHIIQELPLDNTFVG-CD 1007
Cdd:pfam08374  146 FKPDSPDLARHYKSNSPLPAFQLQPESPSAsKKHQAVQELPLDNTFVGtGD 196
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 283-381 5.93e-33

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 122.81  E-value: 5.93e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011005  283 EIEVSIPENAPIGSSVTQLHATDADIGENARIHFYfsnLVSNIAKRLFHLNTTTGLITVKEPLDREESPSHKLLVLATDG 362
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYS---IVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                          90       100
                  ....*....|....*....|.
gi 569011005  363 GSTP--ARATVLVNVTDINDN 381
Cdd:cd11304    78 GGPPlsSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 604-699 1.54e-31

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 118.57  E-value: 1.54e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011005  604 EYNFYVPESLPKHGTVGLITVTDPDYGENSAVTLSILDVNDQ--FTIDPQSGVIRPNISFDRERQESYTFYVKAEDGGRV 681
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDglFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                          90
                  ....*....|....*...
gi 569011005  682 SRSSTARVTINVVDVNDN 699
Cdd:cd11304    81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 501-596 2.42e-31

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 118.18  E-value: 2.42e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011005  501 ISLSVPENNSPGAQLTKISATDADSGQNAEISY-MLGFDAPPEFNLDQRTGILTAVKKLDREKQEKYYFTVLAQDNGIPP 579
Cdd:cd11304     2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYsIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                          90
                  ....*....|....*..
gi 569011005  580 LMSNATVFVTVLDQNDN 596
Cdd:cd11304    82 LSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 173-275 2.13e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 83.90  E-value: 2.13e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011005  173 VINISIPENSAINSRYSLPAAIDPDIGINGVQNYQLIkSQNIFGLDVIETPEGDkmpqLIVQKELDREEKDTYVMKVKVE 252
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIV-SGNEDGLFSIDPSTGE----ITTAKPLDREEQSSYTLTVTAT 75

                          90       100
                  ....*....|....*....|...
gi 569011005  253 DGGFPQRSSTAILQVSVADTNDN 275
Cdd:cd11304    76 DGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 710-802 6.15e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 74.27  E-value: 6.15e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011005  710 YSFEwVLPSTNPGTVVFKVVAIDDDIGMNAEVLYSIVGGNTKGLFMIEQTSGNITLKEKCMVSDLGLHRVIVKANDLGQP 789
Cdd:cd11304     2 YEVS-VPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                          90
                  ....*....|...
gi 569011005  790 dSLFNVVNVNFFI 802
Cdd:cd11304    81 -PLSSTATVTITV 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 414-494 1.08e-10

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


:

Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 58.90  E-value: 1.08e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011005    414 TVMDKDSEHNGRVTCF---TDHEVPFRLRPvfsNQFLLETAAFLDFESTREYAIKLLAADAGKPPLNQSSMLLIKVKDEN 490
Cdd:smart00112    1 SATDADSGENGKVTYSilsGNDDGLFSIDP---ETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                    ....
gi 569011005    491 DNAP 494
Cdd:smart00112   78 DNAP 81
Cadherin_2 super family cl29227
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 58-129 2.00e-05

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


The actual alignment was detected with superfamily member pfam08266:

Pssm-ID: 462413  Cd Length: 83  Bit Score: 43.67  E-value: 2.00e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 569011005    58 YTVREEMPENVLIGDLLKDLNLSLipdKSLTTpMQFKLVYKtGDVPLIRIEEGTGEIFTTGaRIDREKLCAG 129
Cdd:pfam08266    4 YSVPEETERGSFVGNLAKDLGLEV---GELAA-RGARVVSK-GNKQYFQLNPETGDLLLNE-KLDREELCGS 69
 
Name Accession Description Interval E-value
Protocadherin pfam08374
Protocadherin; The structure of protocadherins is similar to that of classic cadherins ...
 805-1007 1.71e-89

Protocadherin; The structure of protocadherins is similar to that of classic cadherins (pfam00028), but particularly on the cytoplasmic domains they also have some unique features. They are expressed in a variety of organizms and are found in high concentrations in the brain where they seem to be localized mainly at cell-cell contact sites. Their expression seems to be developmentally regulated.


Pssm-ID: 462451  Cd Length: 217  Bit Score: 285.87  E-value: 1.71e-89
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011005   805 SVPNATLIYELVRRSIDAPANQNT-ETTSASSPTTDYVKIMVAIVAGTITVVLVIFITAVVR-CRQP--PHLKASQKnkQ 880
Cdd:pfam08374    1 SLANATLVEELVRRSLETPLDRDIaGDPDYSSLGKDYLKILIAILAGAMTVILVIFIVVLVRyCRQKekPGYKAGKK--Q 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011005   881 NSEWVTPNPENRQMIMMKKKKKKKKKHP--PKNLLLNFVTIEEAKPDDGENERNSVTLDLPIeleeqtmgkynwgTTPTT 958
Cdd:pfam08374   79 NSDWVTPNPENKQMKGKKKKKKKRPKPAklPKSLLLNLVTIEESKPDDVENEGDSPRIDLPI-------------TLPTT 145

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|.
gi 569011005   959 FKPDSPDLARHYKSASPQPAFQIQPETPLN-SKHHIIQELPLDNTFVG-CD 1007
Cdd:pfam08374  146 FKPDSPDLARHYKSNSPLPAFQLQPESPSAsKKHQAVQELPLDNTFVGtGD 196
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 283-381 5.93e-33

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 122.81  E-value: 5.93e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011005  283 EIEVSIPENAPIGSSVTQLHATDADIGENARIHFYfsnLVSNIAKRLFHLNTTTGLITVKEPLDREESPSHKLLVLATDG 362
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYS---IVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                          90       100
                  ....*....|....*....|.
gi 569011005  363 GSTP--ARATVLVNVTDINDN 381
Cdd:cd11304    78 GGPPlsSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 604-699 1.54e-31

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 118.57  E-value: 1.54e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011005  604 EYNFYVPESLPKHGTVGLITVTDPDYGENSAVTLSILDVNDQ--FTIDPQSGVIRPNISFDRERQESYTFYVKAEDGGRV 681
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDglFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                          90
                  ....*....|....*...
gi 569011005  682 SRSSTARVTINVVDVNDN 699
Cdd:cd11304    81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 501-596 2.42e-31

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 118.18  E-value: 2.42e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011005  501 ISLSVPENNSPGAQLTKISATDADSGQNAEISY-MLGFDAPPEFNLDQRTGILTAVKKLDREKQEKYYFTVLAQDNGIPP 579
Cdd:cd11304     2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYsIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                          90
                  ....*....|....*..
gi 569011005  580 LMSNATVFVTVLDQNDN 596
Cdd:cd11304    82 LSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 519-598 2.83e-24

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 97.42  E-value: 2.83e-24
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011005    519 SATDADSGQNAEISY-MLGFDAPPEFNLDQRTGILTAVKKLDREKQEKYYFTVLAQDNGIPPLMSNATVFVTVLDQNDNS 597
Cdd:smart00112    1 SATDADSGENGKVTYsILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 569011005    598 P 598
Cdd:smart00112   81 P 81
Cadherin pfam00028
Cadherin domain;
284-376 1.86e-23

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 95.45  E-value: 1.86e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011005   284 IEVSIPENAPIGSSVTQLHATDADIGENARIHFyfsNLVSNIAKRLFHLNTTTGLITVKEPLDREESPSHKLLVLATDGG 363
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFY---SILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSG 77

                           90
                   ....*....|...
gi 569011005   364 STPARATVLVNVT 376
Cdd:pfam00028   78 GPPLSSTATVTIT 90
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 623-701 1.61e-22

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 92.41  E-value: 1.61e-22
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011005    623 TVTDPDYGENSAVTLSILD--VNDQFTIDPQSGVIRPNISFDRERQESYTFYVKAEDGGRVSRSSTARVTINVVDVNDNK 700
Cdd:smart00112    1 SATDADSGENGKVTYSILSgnDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 569011005    701 P 701
Cdd:smart00112   81 P 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 302-383 5.63e-22

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 90.87  E-value: 5.63e-22
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011005    302 HATDADIGENARIHFYfsnLVSNIAKRLFHLNTTTGLITVKEPLDREESPSHKLLVLATDGGSTP--ARATVLVNVTDIN 379
Cdd:smart00112    1 SATDADSGENGKVTYS---ILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPlsSTATVTITVLDVN 77


                    ....
gi 569011005    380 DNVP 383
Cdd:smart00112   78 DNAP 81
Cadherin pfam00028
Cadherin domain;
605-693 8.36e-21

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 87.74  E-value: 8.36e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011005   605 YNFYVPESLPKHGTVGLITVTDPDYGENSAVTLSIL--DVNDQFTIDPQSGVIRPNISFDRERQESYTFYVKAEDGGRVS 682
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILggGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|.
gi 569011005   683 RSSTARVTINV 693
Cdd:pfam00028   81 LSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
501-591 1.43e-20

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 87.36  E-value: 1.43e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011005   501 ISLSVPENNSPGAQLTKISATDADSGQNAEISY-MLGFDAPPEFNLDQRTGILTAVKKLDREKQEKYYFTVLAQDNGIPP 579
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYsILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|..
gi 569011005   580 LMSNATVFVTVL 591
Cdd:pfam00028   81 LSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 173-275 2.13e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 83.90  E-value: 2.13e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011005  173 VINISIPENSAINSRYSLPAAIDPDIGINGVQNYQLIkSQNIFGLDVIETPEGDkmpqLIVQKELDREEKDTYVMKVKVE 252
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIV-SGNEDGLFSIDPSTGE----ITTAKPLDREEQSSYTLTVTAT 75

                          90       100
                  ....*....|....*....|...
gi 569011005  253 DGGFPQRSSTAILQVSVADTNDN 275
Cdd:cd11304    76 DGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 710-802 6.15e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 74.27  E-value: 6.15e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011005  710 YSFEwVLPSTNPGTVVFKVVAIDDDIGMNAEVLYSIVGGNTKGLFMIEQTSGNITLKEKCMVSDLGLHRVIVKANDLGQP 789
Cdd:cd11304     2 YEVS-VPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                          90
                  ....*....|...
gi 569011005  790 dSLFNVVNVNFFI 802
Cdd:cd11304    81 -PLSSTATVTITV 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 193-277 9.84e-16

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 73.15  E-value: 9.84e-16
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011005    193 AIDPDIGINGVQNYQlIKSQNIFGLDVIETPEGdkmpQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVADT 272
Cdd:smart00112    2 ATDADSGENGKVTYS-ILSGNDDGLFSIDPETG----EITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDV 76


                    ....*
gi 569011005    273 NDNHP 277
Cdd:smart00112   77 NDNAP 81
Cadherin pfam00028
Cadherin domain;
174-269 5.96e-11

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 60.01  E-value: 5.96e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011005   174 INISIPENSAINSRYSLPAAIDPDIGINGVQNYqLIKSQNIFGLDVIETPEGDkmpqLIVQKELDREEKDTYVMKVKVED 253
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFY-SILGGGPGGNFRIDPDTGD----ISTTKPLDRESIGEYELTVEATD 75

                           90
                   ....*....|....*.
gi 569011005   254 GGFPQRSSTAILQVSV 269
Cdd:pfam00028   76 SGGPPLSSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 414-494 1.08e-10

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 58.90  E-value: 1.08e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011005    414 TVMDKDSEHNGRVTCF---TDHEVPFRLRPvfsNQFLLETAAFLDFESTREYAIKLLAADAGKPPLNQSSMLLIKVKDEN 490
Cdd:smart00112    1 SATDADSGENGKVTYSilsGNDDGLFSIDP---ETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                    ....
gi 569011005    491 DNAP 494
Cdd:smart00112   78 DNAP 81
Cadherin pfam00028
Cadherin domain;
400-486 1.20e-08

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 53.46  E-value: 1.20e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011005   400 LSENAPLNTKIALITVMDKDSEHNGRVTcftdhevpFR-LRPVFSNQF-------LLETAAFLDFESTREYAIKLLAADA 471
Cdd:pfam00028    5 VPENAPVGTEVLTVTATDPDLGPNGRIF--------YSiLGGGPGGNFridpdtgDISTTKPLDRESIGEYELTVEATDS 76

                           90
                   ....*....|....*
gi 569011005   472 GKPPLNQSSMLLIKV 486
Cdd:pfam00028   77 GGPPLSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
721-802 1.32e-08

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 53.07  E-value: 1.32e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011005   721 PGTVVFKVVAIDDDIGMNAEVLYSIVGGNTKGLFMIEQTSGNITLKEKCMVSDLGLHRVIVKANDLGQPdSLFNVVNVNF 800
Cdd:pfam00028   11 VGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGP-PLSSTATVTI 89


                   ..
gi 569011005   801 FI 802
Cdd:pfam00028   90 TV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 729-802 2.32e-07

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 49.27  E-value: 2.32e-07
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 569011005    729 VAIDDDIGMNAEVLYSIVGGNTKGLFMIEQTSGNITLKEKCMVSDLGLHRVIVKANDLGQPdSLFNVVNVNFFI 802
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGP-PLSSTATVTITV 73
Cadherin_2 pfam08266
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 58-129 2.00e-05

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


Pssm-ID: 462413  Cd Length: 83  Bit Score: 43.67  E-value: 2.00e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 569011005    58 YTVREEMPENVLIGDLLKDLNLSLipdKSLTTpMQFKLVYKtGDVPLIRIEEGTGEIFTTGaRIDREKLCAG 129
Cdd:pfam08266    4 YSVPEETERGSFVGNLAKDLGLEV---GELAA-RGARVVSK-GNKQYFQLNPETGDLLLNE-KLDREELCGS 69
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 57-165 8.75e-03

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 36.91  E-value: 8.75e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011005   57 NYTVREEMPENVLIGDLL-KDlnlsliPDKSLTTPMQFKLVYKTGDvPLIRIEEGTGEIFTTGaRIDREKlcagivldaR 135
Cdd:cd11304     3 EVSVPENAPPGTVVLTVSaTD------PDSGENGEVTYSIVSGNED-GLFSIDPSTGEITTAK-PLDREE---------Q 65

                          90       100       110
                  ....*....|....*....|....*....|...
gi 569011005  136 CFYEVEVAVLPDEIFRL---VKIRFLIEDINDN 165
Cdd:cd11304    66 SSYTLTVTATDGGGPPLsstATVTITVLDVNDN 98
 
Name Accession Description Interval E-value
Protocadherin pfam08374
Protocadherin; The structure of protocadherins is similar to that of classic cadherins ...
 805-1007 1.71e-89

Protocadherin; The structure of protocadherins is similar to that of classic cadherins (pfam00028), but particularly on the cytoplasmic domains they also have some unique features. They are expressed in a variety of organizms and are found in high concentrations in the brain where they seem to be localized mainly at cell-cell contact sites. Their expression seems to be developmentally regulated.


Pssm-ID: 462451  Cd Length: 217  Bit Score: 285.87  E-value: 1.71e-89
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011005   805 SVPNATLIYELVRRSIDAPANQNT-ETTSASSPTTDYVKIMVAIVAGTITVVLVIFITAVVR-CRQP--PHLKASQKnkQ 880
Cdd:pfam08374    1 SLANATLVEELVRRSLETPLDRDIaGDPDYSSLGKDYLKILIAILAGAMTVILVIFIVVLVRyCRQKekPGYKAGKK--Q 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011005   881 NSEWVTPNPENRQMIMMKKKKKKKKKHP--PKNLLLNFVTIEEAKPDDGENERNSVTLDLPIeleeqtmgkynwgTTPTT 958
Cdd:pfam08374   79 NSDWVTPNPENKQMKGKKKKKKKRPKPAklPKSLLLNLVTIEESKPDDVENEGDSPRIDLPI-------------TLPTT 145

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|.
gi 569011005   959 FKPDSPDLARHYKSASPQPAFQIQPETPLN-SKHHIIQELPLDNTFVG-CD 1007
Cdd:pfam08374  146 FKPDSPDLARHYKSNSPLPAFQLQPESPSAsKKHQAVQELPLDNTFVGtGD 196
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 283-381 5.93e-33

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 122.81  E-value: 5.93e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011005  283 EIEVSIPENAPIGSSVTQLHATDADIGENARIHFYfsnLVSNIAKRLFHLNTTTGLITVKEPLDREESPSHKLLVLATDG 362
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYS---IVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                          90       100
                  ....*....|....*....|.
gi 569011005  363 GSTP--ARATVLVNVTDINDN 381
Cdd:cd11304    78 GGPPlsSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 604-699 1.54e-31

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 118.57  E-value: 1.54e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011005  604 EYNFYVPESLPKHGTVGLITVTDPDYGENSAVTLSILDVNDQ--FTIDPQSGVIRPNISFDRERQESYTFYVKAEDGGRV 681
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDglFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                          90
                  ....*....|....*...
gi 569011005  682 SRSSTARVTINVVDVNDN 699
Cdd:cd11304    81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 501-596 2.42e-31

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 118.18  E-value: 2.42e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011005  501 ISLSVPENNSPGAQLTKISATDADSGQNAEISY-MLGFDAPPEFNLDQRTGILTAVKKLDREKQEKYYFTVLAQDNGIPP 579
Cdd:cd11304     2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYsIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                          90
                  ....*....|....*..
gi 569011005  580 LMSNATVFVTVLDQNDN 596
Cdd:cd11304    82 LSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 519-598 2.83e-24

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 97.42  E-value: 2.83e-24
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011005    519 SATDADSGQNAEISY-MLGFDAPPEFNLDQRTGILTAVKKLDREKQEKYYFTVLAQDNGIPPLMSNATVFVTVLDQNDNS 597
Cdd:smart00112    1 SATDADSGENGKVTYsILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 569011005    598 P 598
Cdd:smart00112   81 P 81
Cadherin pfam00028
Cadherin domain;
284-376 1.86e-23

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 95.45  E-value: 1.86e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011005   284 IEVSIPENAPIGSSVTQLHATDADIGENARIHFyfsNLVSNIAKRLFHLNTTTGLITVKEPLDREESPSHKLLVLATDGG 363
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFY---SILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSG 77

                           90
                   ....*....|...
gi 569011005   364 STPARATVLVNVT 376
Cdd:pfam00028   78 GPPLSSTATVTIT 90
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 623-701 1.61e-22

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 92.41  E-value: 1.61e-22
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011005    623 TVTDPDYGENSAVTLSILD--VNDQFTIDPQSGVIRPNISFDRERQESYTFYVKAEDGGRVSRSSTARVTINVVDVNDNK 700
Cdd:smart00112    1 SATDADSGENGKVTYSILSgnDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 569011005    701 P 701
Cdd:smart00112   81 P 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 302-383 5.63e-22

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 90.87  E-value: 5.63e-22
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011005    302 HATDADIGENARIHFYfsnLVSNIAKRLFHLNTTTGLITVKEPLDREESPSHKLLVLATDGGSTP--ARATVLVNVTDIN 379
Cdd:smart00112    1 SATDADSGENGKVTYS---ILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPlsSTATVTITVLDVN 77


                    ....
gi 569011005    380 DNVP 383
Cdd:smart00112   78 DNAP 81
Cadherin pfam00028
Cadherin domain;
605-693 8.36e-21

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 87.74  E-value: 8.36e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011005   605 YNFYVPESLPKHGTVGLITVTDPDYGENSAVTLSIL--DVNDQFTIDPQSGVIRPNISFDRERQESYTFYVKAEDGGRVS 682
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILggGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|.
gi 569011005   683 RSSTARVTINV 693
Cdd:pfam00028   81 LSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
501-591 1.43e-20

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 87.36  E-value: 1.43e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011005   501 ISLSVPENNSPGAQLTKISATDADSGQNAEISY-MLGFDAPPEFNLDQRTGILTAVKKLDREKQEKYYFTVLAQDNGIPP 579
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYsILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|..
gi 569011005   580 LMSNATVFVTVL 591
Cdd:pfam00028   81 LSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 173-275 2.13e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 83.90  E-value: 2.13e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011005  173 VINISIPENSAINSRYSLPAAIDPDIGINGVQNYQLIkSQNIFGLDVIETPEGDkmpqLIVQKELDREEKDTYVMKVKVE 252
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIV-SGNEDGLFSIDPSTGE----ITTAKPLDREEQSSYTLTVTAT 75

                          90       100
                  ....*....|....*....|...
gi 569011005  253 DGGFPQRSSTAILQVSVADTNDN 275
Cdd:cd11304    76 DGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 710-802 6.15e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 74.27  E-value: 6.15e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011005  710 YSFEwVLPSTNPGTVVFKVVAIDDDIGMNAEVLYSIVGGNTKGLFMIEQTSGNITLKEKCMVSDLGLHRVIVKANDLGQP 789
Cdd:cd11304     2 YEVS-VPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                          90
                  ....*....|...
gi 569011005  790 dSLFNVVNVNFFI 802
Cdd:cd11304    81 -PLSSTATVTITV 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 193-277 9.84e-16

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 73.15  E-value: 9.84e-16
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011005    193 AIDPDIGINGVQNYQlIKSQNIFGLDVIETPEGdkmpQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVADT 272
Cdd:smart00112    2 ATDADSGENGKVTYS-ILSGNDDGLFSIDPETG----EITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDV 76


                    ....*
gi 569011005    273 NDNHP 277
Cdd:smart00112   77 NDNAP 81
Cadherin pfam00028
Cadherin domain;
174-269 5.96e-11

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 60.01  E-value: 5.96e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011005   174 INISIPENSAINSRYSLPAAIDPDIGINGVQNYqLIKSQNIFGLDVIETPEGDkmpqLIVQKELDREEKDTYVMKVKVED 253
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFY-SILGGGPGGNFRIDPDTGD----ISTTKPLDRESIGEYELTVEATD 75

                           90
                   ....*....|....*.
gi 569011005   254 GGFPQRSSTAILQVSV 269
Cdd:pfam00028   76 SGGPPLSSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 414-494 1.08e-10

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 58.90  E-value: 1.08e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011005    414 TVMDKDSEHNGRVTCF---TDHEVPFRLRPvfsNQFLLETAAFLDFESTREYAIKLLAADAGKPPLNQSSMLLIKVKDEN 490
Cdd:smart00112    1 SATDADSGENGKVTYSilsGNDDGLFSIDP---ETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                    ....
gi 569011005    491 DNAP 494
Cdd:smart00112   78 DNAP 81
Cadherin pfam00028
Cadherin domain;
400-486 1.20e-08

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 53.46  E-value: 1.20e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011005   400 LSENAPLNTKIALITVMDKDSEHNGRVTcftdhevpFR-LRPVFSNQF-------LLETAAFLDFESTREYAIKLLAADA 471
Cdd:pfam00028    5 VPENAPVGTEVLTVTATDPDLGPNGRIF--------YSiLGGGPGGNFridpdtgDISTTKPLDRESIGEYELTVEATDS 76

                           90
                   ....*....|....*
gi 569011005   472 GKPPLNQSSMLLIKV 486
Cdd:pfam00028   77 GGPPLSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
721-802 1.32e-08

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 53.07  E-value: 1.32e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011005   721 PGTVVFKVVAIDDDIGMNAEVLYSIVGGNTKGLFMIEQTSGNITLKEKCMVSDLGLHRVIVKANDLGQPdSLFNVVNVNF 800
Cdd:pfam00028   11 VGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGP-PLSSTATVTI 89


                   ..
gi 569011005   801 FI 802
Cdd:pfam00028   90 TV 91
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 501-596 2.51e-08

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 52.73  E-value: 2.51e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011005  501 ISLSVPENNSPGAQLTKI-SATDADSGQNAEISYMlGFDAPPE-FNLDQRTGILTAVKKLDREKQEKYYFTVLAQDNGIP 578
Cdd:cd00031     2 PDGSAVEGRSRGSFRVSIpTDLIASSGEIIKISAA-GKEALPSwLHWEPHSGILEGLEKLDREDKGVHYISVSAASLGAN 80

                          90
                  ....*....|....*...
gi 569011005  579 PLMSNATVFVTVLDQNDN 596
Cdd:cd00031    81 VPQTSSVFSIEVYDENDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 729-802 2.32e-07

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 49.27  E-value: 2.32e-07
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 569011005    729 VAIDDDIGMNAEVLYSIVGGNTKGLFMIEQTSGNITLKEKCMVSDLGLHRVIVKANDLGQPdSLFNVVNVNFFI 802
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGP-PLSSTATVTITV 73
Cadherin_2 pfam08266
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 284-349 2.57e-06

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


Pssm-ID: 462413  Cd Length: 83  Bit Score: 46.37  E-value: 2.57e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 569011005   284 IEVSIPENAPIGSSVTQLhATD--ADIGE----NARIhfyfsnlVSNIAKRLFHLNTTTGLITVKEPLDREE 349
Cdd:pfam08266    2 IRYSVPEETERGSFVGNL-AKDlgLEVGElaarGARV-------VSKGNKQYFQLNPETGDLLLNEKLDREE 65
Cadherin_2 pfam08266
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 58-129 2.00e-05

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


Pssm-ID: 462413  Cd Length: 83  Bit Score: 43.67  E-value: 2.00e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 569011005    58 YTVREEMPENVLIGDLLKDLNLSLipdKSLTTpMQFKLVYKtGDVPLIRIEEGTGEIFTTGaRIDREKLCAG 129
Cdd:pfam08266    4 YSVPEETERGSFVGNLAKDLGLEV---GELAA-RGARVVSK-GNKQYFQLNPETGDLLLNE-KLDREELCGS 69
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 284-381 1.78e-03

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 38.86  E-value: 1.78e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011005  284 IEVSIPENAPIGSSVTQLHAT-DADIGENARIhfyfSNLVSNIAKRLFHLNTTTGLITVKEPLDREESPSHKLLVLA-TD 361
Cdd:cd00031     2 PDGSAVEGRSRGSFRVSIPTDlIASSGEIIKI----SAAGKEALPSWLHWEPHSGILEGLEKLDREDKGVHYISVSAaSL 77

                          90       100
                  ....*....|....*....|.
gi 569011005  362 GGSTPARATVLV-NVTDINDN 381
Cdd:cd00031    78 GANVPQTSSVFSiEVYDENDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 57-165 8.75e-03

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 36.91  E-value: 8.75e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011005   57 NYTVREEMPENVLIGDLL-KDlnlsliPDKSLTTPMQFKLVYKTGDvPLIRIEEGTGEIFTTGaRIDREKlcagivldaR 135
Cdd:cd11304     3 EVSVPENAPPGTVVLTVSaTD------PDSGENGEVTYSIVSGNED-GLFSIDPSTGEITTAK-PLDREE---------Q 65

                          90       100       110
                  ....*....|....*....|....*....|...
gi 569011005  136 CFYEVEVAVLPDEIFRL---VKIRFLIEDINDN 165
Cdd:cd11304    66 SSYTLTVTATDGGGPPLsstATVTITVLDVNDN 98
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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