|
Name |
Accession |
Description |
Interval |
E-value |
| DEXHc_HARP_SMARCAL1 |
cd18010 |
DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin ... |
41-260 |
2.07e-105 |
|
DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1, also known as HARP) is recruited to stalled replication forks to promote repair and helps restart replication. It plays a role in DNA repair, telomere maintenance and replication fork stability in response to DNA replication stress. Mutations cause Schimke Immunoosseous Dysplasia. SMARCAL1 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350768 [Multi-domain] Cd Length: 213 Bit Score: 329.17 E-value: 2.07e-105
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 41 LLPFQKDGIVFALRRDGRCMVADEMGLGKTIQAIAIAYFYKEEWPLLIVVPSSLRYPWIEELEKWIPELEPEEINVVMNK 120
Cdd:cd18010 1 LLPFQREGVCFALRRGGRVLIADEMGLGKTVQAIAIAAYYREEWPLLIVCPSSLRLTWADEIERWLPSLPPDDIQVIVKS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 121 TDIGRIPGSRVTVLGYGLLTTDAETLLDalntQNFRVVIVDESHYMKSRTAARSKILLPMVQKARRAILLTGTPALGRPE 200
Cdd:cd18010 81 KDGLRDGDAKVVIVSYDLLRRLEKQLLA----RKFKVVICDESHYLKNSKAKRTKAALPLLKRAKRVILLSGTPALSRPI 156
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568908697 201 ELFMQIEALFPQKFGTWIEYAKRYCNAHvryFGKRRQWDCrGASNLSELHQLL-NDIMIRR 260
Cdd:cd18010 157 ELFTQLDALDPKLFGRFHDFGRRYCAAK---QGGFGWDYS-GSSNLEELHLLLlATIMIRR 213
|
|
| HepA |
COG0553 |
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ... |
28-468 |
9.58e-92 |
|
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];
Pssm-ID: 440319 [Multi-domain] Cd Length: 682 Bit Score: 309.08 E-value: 9.58e-92
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 28 TQLDFLPDKLRTKLLPFQKDGIVFALRRD---GRCMVADEMGLGKTIQAIAIAYFYKEE---WPLLIVVPSSLRYPWIEE 101
Cdd:COG0553 229 EALESLPAGLKATLRPYQLEGAAWLLFLRrlgLGGLLADDMGLGKTIQALALLLELKERglaRPVLIVAPTSLVGNWQRE 308
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 102 LEKWIPELEPEEINVVMN-KTDIGRIPGSRVTVLGYGLLTTDAETLLDalntQNFRVVIVDESHYMKSRTAARSKILlpM 180
Cdd:COG0553 309 LAKFAPGLRVLVLDGTRErAKGANPFEDADLVITSYGLLRRDIELLAA----VDWDLVILDEAQHIKNPATKRAKAV--R 382
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 181 VQKARRAILLTGTPALGRPEELFMQIEALFPQKFGTWIEYAKRYCNAHVRYfgkrrqwdcrGASNLSELHQLLNDIMIRR 260
Cdd:COG0553 383 ALKARHRLALTGTPVENRLEELWSLLDFLNPGLLGSLKAFRERFARPIEKG----------DEEALERLRRLLRPFLLRR 452
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 261 LKSEVLSQLPPKVRQRIPFDLPPA------AVKElnasfEEWQKLMRAPNSGAMETVMGLITRMfKQTAI---------- 324
Cdd:COG0553 453 TKEDVLKDLPEKTEETLYVELTPEqralyeAVLE-----YLRRELEGAEGIRRRGLILAALTRL-RQICShpallleega 526
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 325 ------AKAGAVKDYIKMLLQNDSlKFLVFAHHLSMLQACTEAVIESKSRYIRIDGSVPSSERIHLVNQFQKDPDTRVAI 398
Cdd:COG0553 527 elsgrsAKLEALLELLEELLAEGE-KVLVFSQFTDTLDLLEERLEERGIEYAYLHGGTSAEERDELVDRFQEGPEAPVFL 605
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 399 LSIQAAGQGLTFTAASHVVFAELYWDPGHIKQAEDRAHRIGQCSSVNIHYLIANGTLDSLMWAMLNRKAQ 468
Cdd:COG0553 606 ISLKAGGEGLNLTAADHVIHYDLWWNPAVEEQAIDRAHRIGQTRDVQVYKLVAEGTIEEKILELLEEKRA 675
|
|
| SF2_C_SNF |
cd18793 |
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) ... |
325-450 |
1.67e-44 |
|
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350180 [Multi-domain] Cd Length: 135 Bit Score: 157.25 E-value: 1.67e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 325 AKAGAVKDYIKMLLQNDSlKFLVFAHHLSMLQACTEAVIESKSRYIRIDGSVPSSERIHLVNQFQKDPDTRVAILSIQAA 404
Cdd:cd18793 11 GKLEALLELLEELREPGE-KVLIFSQFTDTLDILEEALRERGIKYLRLDGSTSSKERQKLVDRFNEDPDIRVFLLSTKAG 89
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 568908697 405 GQGLTFTAASHVVFAELYWDPGHIKQAEDRAHRIGQCSSVNIHYLI 450
Cdd:cd18793 90 GVGLNLTAANRVILYDPWWNPAVEEQAIDRAHRIGQKKPVVVYRLI 135
|
|
| SNF2-rel_dom |
pfam00176 |
SNF2-related domain; This domain is found in proteins involved in a variety of processes ... |
45-273 |
7.35e-34 |
|
SNF2-related domain; This domain is found in proteins involved in a variety of processes including transcription regulation (e.g., SNF2, STH1, brahma, MOT1), DNA repair (e.g., ERCC6, RAD16, RAD5), DNA recombination (e.g., RAD54), and chromatin unwinding (e.g., ISWI) as well as a variety of other proteins with little functional information (e.g., lodestar, ETL1). SNF2 functions as the ATPase component of the SNF2/SWI multisubunit complex, which utilizes energy derived from ATP hydrolysis to disrupt histone-DNA interactions, resulting in the increased accessibility of DNA to transcription factors.
Pssm-ID: 425504 [Multi-domain] Cd Length: 289 Bit Score: 132.04 E-value: 7.35e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 45 QKDGIVFALRRD---GR-CMVADEMGLGKTIQAIA-IAYFYKEE----WPLLIVVPSSLRYPWIEELEKWipeLEPEEIN 115
Cdd:pfam00176 2 QIEGVNWMLSLEnnlGRgGILADEMGLGKTLQTISlLLYLKHVDknwgGPTLIVVPLSLLHNWMNEFERW---VSPPALR 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 116 VVM---NKTDIGRIPGSRVTVLGYGLLTTDAETLL---DALNTQNFRVVIVDESHYMKSRTAARSKILLPMvqKARRAIL 189
Cdd:pfam00176 79 VVVlhgNKRPQERWKNDPNFLADFDVVITTYETLRkhkELLKKVHWHRIVLDEGHRLKNSKSKLSKALKSL--KTRNRWI 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 190 LTGTPALGRPEELFMQIEALFPQKFGTWIEYAKRYCNAHVRYFGKRRQWdcrgasnlsELHQLLNDIMIRRLKSEVLSQL 269
Cdd:pfam00176 157 LTGTPLQNNLEELWALLNFLRPGPFGSLSTFRNWFDRPIERGGGKKGVS---------RLHKLLKPFLLRRTKKDVEKSL 227
|
....
gi 568908697 270 PPKV 273
Cdd:pfam00176 228 PPKV 231
|
|
| PLN03142 |
PLN03142 |
Probable chromatin-remodeling complex ATPase chain; Provisional |
60-446 |
6.19e-23 |
|
Probable chromatin-remodeling complex ATPase chain; Provisional
Pssm-ID: 215601 [Multi-domain] Cd Length: 1033 Bit Score: 106.04 E-value: 6.19e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 60 MVADEMGLGKTIQAIA-IAYFYKEE---WPLLIVVPSSLRYPWIEELEKWIPELE-------PEEINVVMNKTdigRIPG 128
Cdd:PLN03142 192 ILADEMGLGKTLQTISlLGYLHEYRgitGPHMVVAPKSTLGNWMNEIRRFCPVLRavkfhgnPEERAHQREEL---LVAG 268
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 129 srvtvlGYGLLTTDAETLL---DALNTQNFRVVIVDESHYMKSRTAARSKILLPMVQKARraILLTGTPALGRPEELFMQ 205
Cdd:PLN03142 269 ------KFDVCVTSFEMAIkekTALKRFSWRYIIIDEAHRIKNENSLLSKTMRLFSTNYR--LLITGTPLQNNLHELWAL 340
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 206 IEALFPQKFGTwieyakrycnahvryFGKRRQWDCRGASN-----LSELHQLLNDIMIRRLKSEVLSQLPPKVRQRIPFD 280
Cdd:PLN03142 341 LNFLLPEIFSS---------------AETFDEWFQISGENdqqevVQQLHKVLRPFLLRRLKSDVEKGLPPKKETILKVG 405
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 281 LPPAAVKELNASFeewQKLMRAPNSGA-----METVMGL-------------------ITRMFKQTAIAKAGAVKDYIKM 336
Cdd:PLN03142 406 MSQMQKQYYKALL---QKDLDVVNAGGerkrlLNIAMQLrkccnhpylfqgaepgppyTTGEHLVENSGKMVLLDKLLPK 482
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 337 LLQNDSlKFLVFAHHLSMLQACTEAVIESKSRYIRIDGSVPSSERIHLVNQFQKDPDTR-VAILSIQAAGQGLTFTAASH 415
Cdd:PLN03142 483 LKERDS-RVLIFSQMTRLLDILEDYLMYRGYQYCRIDGNTGGEDRDASIDAFNKPGSEKfVFLLSTRAGGLGINLATADI 561
|
410 420 430
....*....|....*....|....*....|.
gi 568908697 416 VVFAELYWDPGHIKQAEDRAHRIGQCSSVNI 446
Cdd:PLN03142 562 VILYDSDWNPQVDLQAQDRAHRIGQKKEVQV 592
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
33-216 |
3.13e-21 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 92.94 E-value: 3.13e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 33 LPDKLRTKLLPFQKDGIVFALRRDGRCMVADEMGLGKTIQA-IAIAYFYKEE--WPLLIVVP-SSLRYPWIEELEKWIPE 108
Cdd:smart00487 1 IEKFGFEPLRPYQKEAIEALLSGLRDVILAAPTGSGKTLAAlLPALEALKRGkgGRVLVLVPtRELAEQWAEELKKLGPS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 109 LEPEEINVV--MNKTDIGRIPGSRVTVLgygLLTTDaETLLDAL-----NTQNFRVVIVDESHYMKSRTAARS-KILLPM 180
Cdd:smart00487 81 LGLKVVGLYggDSKREQLRKLESGKTDI---LVTTP-GRLLDLLendklSLSNVDLVILDEAHRLLDGGFGDQlEKLLKL 156
|
170 180 190
....*....|....*....|....*....|....*...
gi 568908697 181 VQKARRAILLTGTPALGRPE--ELFMQIEALFPQKFGT 216
Cdd:smart00487 157 LPKNVQLLLLSATPPEEIENllELFLNDPVFIDVGFTP 194
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
334-439 |
7.15e-15 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 71.47 E-value: 7.15e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 334 IKMLLQNDSLKFLVFAHHLSMLQaCTEAVIESKSRYIRIDGSVPSSERIHLVNQFqKDPDTRVaILSIQAAGQGLTFTAA 413
Cdd:pfam00271 7 LELLKKERGGKVLIFSQTKKTLE-AELLLEKEGIKVARLHGDLSQEEREEILEDF-RKGKIDV-LVATDVAERGLDLPDV 83
|
90 100
....*....|....*....|....*.
gi 568908697 414 SHVVFAELYWDPGHIKQAEDRAHRIG 439
Cdd:pfam00271 84 DLVINYDLPWNPASYIQRIGRAGRAG 109
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
368-439 |
6.68e-13 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 64.93 E-value: 6.68e-13
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568908697 368 RYIRIDGSVPSSERIHLVNQFQKDPdtRVAILSIQAAGQGLTFTAASHVVFAELYWDPGHIKQAEDRAHRIG 439
Cdd:smart00490 13 KVARLHGGLSQEEREEILDKFNNGK--IKVLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGRAGRAG 82
|
|
| DpdE |
NF041062 |
protein DpdE; |
58-200 |
2.65e-11 |
|
protein DpdE;
Pssm-ID: 468989 [Multi-domain] Cd Length: 1048 Bit Score: 68.07 E-value: 2.65e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 58 RCMVADEMGLGKTIQAIAIAYFYKEEWP---LLIVVPSSLRYPWIEELEkwipelepeeinvvmNKTDIGRIPGSRVTVL 134
Cdd:NF041062 172 RYLLADEVGLGKTIEAGLVIRQHLLDNPdarVLVLVPDALVRQWRRELR---------------DKFFLDDFPGARVRVL 236
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568908697 135 GYglltTDAETLLDalNTQNFRVVIVDESHYM-------KSRTAARSKILLPMVQKARRAILLTGTPALGRPE 200
Cdd:NF041062 237 SH----EEPERWEP--LLDAPDLLVVDEAHQLarlawsgDPPERARYRELAALAHAAPRLLLLSATPVLGNEE 303
|
|
| SSL2 |
COG1061 |
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair]; |
40-419 |
7.45e-11 |
|
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
Pssm-ID: 440681 [Multi-domain] Cd Length: 566 Bit Score: 66.20 E-value: 7.45e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 40 KLLPFQKDGI--VFALRRDG--RCMVADEMGLGKTIQAIAIAYFYKEEWPLLIVVPS-SLRYPWIEELEKWIPelepeEI 114
Cdd:COG1061 80 ELRPYQQEALeaLLAALERGggRGLVVAPTGTGKTVLALALAAELLRGKRVLVLVPRrELLEQWAEELRRFLG-----DP 154
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 115 NVVMNKTDIGRipgsRVTVLGYGLLTTDAEtlLDALNtQNFRVVIVDESHymksRTAARS-KILLPMVQKARRaILLTGT 193
Cdd:COG1061 155 LAGGGKKDSDA----PITVATYQSLARRAH--LDELG-DRFGLVIIDEAH----HAGAPSyRRILEAFPAAYR-LGLTAT 222
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 194 PAL--GRPEELFMqiealfpqkfgtwieyakrycnahvrYFGKRRQWDcrgasnlseLHQLLNDIMIRrlksevlsqlPP 271
Cdd:COG1061 223 PFRsdGREILLFL--------------------------FDGIVYEYS---------LKEAIEDGYLA----------PP 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 272 KVRQRipfdlppaavkelnasFEEWQKLMRapnsgAMETVMGLITRMFKQTAIAKAGAVKDYIKMLLQNDslKFLVFAHH 351
Cdd:COG1061 258 EYYGI----------------RVDLTDERA-----EYDALSERLREALAADAERKDKILRELLREHPDDR--KTLVFCSS 314
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568908697 352 LSMLQACTEAVIESKSRYIRIDGSVPSSERIHLVNQFQKDPDTrvAILSIQAAGQGLTFTAASHVVFA 419
Cdd:COG1061 315 VDHAEALAELLNEAGIRAAVVTGDTPKKEREEILEAFRDGELR--ILVTVDVLNEGVDVPRLDVAILL 380
|
|
| HNHc |
cd00085 |
HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic ... |
1025-1090 |
5.22e-08 |
|
HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and anaredoxins.
Pssm-ID: 238038 [Multi-domain] Cd Length: 57 Bit Score: 50.55 E-value: 5.22e-08
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568908697 1025 KSHRKSLLNAAWTAKLPLEqlnemlrnPGEGHFWQVDHIRPVyEGGGQCSLDNLQTLCTVCHKERT 1090
Cdd:cd00085 1 RSHRLVLLARDGLCPYCGK--------PGGTEGLEVDHIIPL-SDGGNNDLDNLVLLCRKCHRKKH 57
|
|
| McrA |
COG1403 |
5-methylcytosine-specific restriction endonuclease McrA [Defense mechanisms]; |
994-1087 |
6.03e-06 |
|
5-methylcytosine-specific restriction endonuclease McrA [Defense mechanisms];
Pssm-ID: 441013 [Multi-domain] Cd Length: 64 Bit Score: 44.97 E-value: 6.03e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 994 LRAQVFATEHGVCQHCGvdaqelflrmrdapkshrksllnaawtaklpleqlnemlrNPGEGHFWQVDHIRPVYEGGGQc 1073
Cdd:COG1403 10 LRRAVLKRDNGRCQYCG----------------------------------------RPFSGDALEVDHIIPRSRGGTD- 48
|
90
....*....|....
gi 568908697 1074 SLDNLQTLCTVCHK 1087
Cdd:COG1403 49 TWENLVLLCRRCNR 62
|
|
| HNH |
pfam01844 |
HNH endonuclease; His-Asn-His (HNH) proteins are a very common family of small nucleic ... |
1057-1092 |
7.24e-06 |
|
HNH endonuclease; His-Asn-His (HNH) proteins are a very common family of small nucleic acid-binding proteins that are generally associated with endonuclease activity.
Pssm-ID: 396422 [Multi-domain] Cd Length: 47 Bit Score: 43.88 E-value: 7.24e-06
10 20 30
....*....|....*....|....*....|....*.
gi 568908697 1057 FWQVDHIRPVYEGGGQcSLDNLQTLCTVCHKERTAQ 1092
Cdd:pfam01844 13 ALTVDHIIPLSDGGAD-DIENLILLCPSCHNKKHNR 47
|
|
| HNHc |
smart00507 |
HNH nucleases; |
1058-1086 |
2.01e-04 |
|
HNH nucleases;
Pssm-ID: 214702 [Multi-domain] Cd Length: 52 Bit Score: 40.13 E-value: 2.01e-04
10 20
....*....|....*....|....*....
gi 568908697 1058 WQVDHIRPvYEGGGQCSLDNLQTLCTVCH 1086
Cdd:smart00507 24 LEVDHIIP-LSDGGNDDLDNLVLLCPKCH 51
|
|
| ZnF_RBZ |
smart00547 |
Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. ... |
625-647 |
1.04e-03 |
|
Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. In RanBPs, this domain binds RanGDP.
Pssm-ID: 197784 [Multi-domain] Cd Length: 25 Bit Score: 37.30 E-value: 1.04e-03
|
| PRK01297 |
PRK01297 |
ATP-dependent RNA helicase RhlB; Provisional |
323-440 |
5.57e-03 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 234938 [Multi-domain] Cd Length: 475 Bit Score: 40.67 E-value: 5.57e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 323 AIAKAGAVKDYIKMLLQNDSLKFLVFAHHLSMLQACTEAVIESKSRYIRIDGSVPSSERIHLVNQFqKDPDTRVAIlSIQ 402
Cdd:PRK01297 316 AVAGSDKYKLLYNLVTQNPWERVMVFANRKDEVRRIEERLVKDGINAAQLSGDVPQHKRIKTLEGF-REGKIRVLV-ATD 393
|
90 100 110
....*....|....*....|....*....|....*...
gi 568908697 403 AAGQGLTFTAASHVVFAELYWDPghikqaEDRAHRIGQ 440
Cdd:PRK01297 394 VAGRGIHIDGISHVINFTLPEDP------DDYVHRIGR 425
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| DEXHc_HARP_SMARCAL1 |
cd18010 |
DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin ... |
41-260 |
2.07e-105 |
|
DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1, also known as HARP) is recruited to stalled replication forks to promote repair and helps restart replication. It plays a role in DNA repair, telomere maintenance and replication fork stability in response to DNA replication stress. Mutations cause Schimke Immunoosseous Dysplasia. SMARCAL1 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350768 [Multi-domain] Cd Length: 213 Bit Score: 329.17 E-value: 2.07e-105
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 41 LLPFQKDGIVFALRRDGRCMVADEMGLGKTIQAIAIAYFYKEEWPLLIVVPSSLRYPWIEELEKWIPELEPEEINVVMNK 120
Cdd:cd18010 1 LLPFQREGVCFALRRGGRVLIADEMGLGKTVQAIAIAAYYREEWPLLIVCPSSLRLTWADEIERWLPSLPPDDIQVIVKS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 121 TDIGRIPGSRVTVLGYGLLTTDAETLLDalntQNFRVVIVDESHYMKSRTAARSKILLPMVQKARRAILLTGTPALGRPE 200
Cdd:cd18010 81 KDGLRDGDAKVVIVSYDLLRRLEKQLLA----RKFKVVICDESHYLKNSKAKRTKAALPLLKRAKRVILLSGTPALSRPI 156
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568908697 201 ELFMQIEALFPQKFGTWIEYAKRYCNAHvryFGKRRQWDCrGASNLSELHQLL-NDIMIRR 260
Cdd:cd18010 157 ELFTQLDALDPKLFGRFHDFGRRYCAAK---QGGFGWDYS-GSSNLEELHLLLlATIMIRR 213
|
|
| HepA |
COG0553 |
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ... |
28-468 |
9.58e-92 |
|
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];
Pssm-ID: 440319 [Multi-domain] Cd Length: 682 Bit Score: 309.08 E-value: 9.58e-92
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 28 TQLDFLPDKLRTKLLPFQKDGIVFALRRD---GRCMVADEMGLGKTIQAIAIAYFYKEE---WPLLIVVPSSLRYPWIEE 101
Cdd:COG0553 229 EALESLPAGLKATLRPYQLEGAAWLLFLRrlgLGGLLADDMGLGKTIQALALLLELKERglaRPVLIVAPTSLVGNWQRE 308
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 102 LEKWIPELEPEEINVVMN-KTDIGRIPGSRVTVLGYGLLTTDAETLLDalntQNFRVVIVDESHYMKSRTAARSKILlpM 180
Cdd:COG0553 309 LAKFAPGLRVLVLDGTRErAKGANPFEDADLVITSYGLLRRDIELLAA----VDWDLVILDEAQHIKNPATKRAKAV--R 382
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 181 VQKARRAILLTGTPALGRPEELFMQIEALFPQKFGTWIEYAKRYCNAHVRYfgkrrqwdcrGASNLSELHQLLNDIMIRR 260
Cdd:COG0553 383 ALKARHRLALTGTPVENRLEELWSLLDFLNPGLLGSLKAFRERFARPIEKG----------DEEALERLRRLLRPFLLRR 452
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 261 LKSEVLSQLPPKVRQRIPFDLPPA------AVKElnasfEEWQKLMRAPNSGAMETVMGLITRMfKQTAI---------- 324
Cdd:COG0553 453 TKEDVLKDLPEKTEETLYVELTPEqralyeAVLE-----YLRRELEGAEGIRRRGLILAALTRL-RQICShpallleega 526
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 325 ------AKAGAVKDYIKMLLQNDSlKFLVFAHHLSMLQACTEAVIESKSRYIRIDGSVPSSERIHLVNQFQKDPDTRVAI 398
Cdd:COG0553 527 elsgrsAKLEALLELLEELLAEGE-KVLVFSQFTDTLDLLEERLEERGIEYAYLHGGTSAEERDELVDRFQEGPEAPVFL 605
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 399 LSIQAAGQGLTFTAASHVVFAELYWDPGHIKQAEDRAHRIGQCSSVNIHYLIANGTLDSLMWAMLNRKAQ 468
Cdd:COG0553 606 ISLKAGGEGLNLTAADHVIHYDLWWNPAVEEQAIDRAHRIGQTRDVQVYKLVAEGTIEEKILELLEEKRA 675
|
|
| SF2_C_SNF |
cd18793 |
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) ... |
325-450 |
1.67e-44 |
|
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350180 [Multi-domain] Cd Length: 135 Bit Score: 157.25 E-value: 1.67e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 325 AKAGAVKDYIKMLLQNDSlKFLVFAHHLSMLQACTEAVIESKSRYIRIDGSVPSSERIHLVNQFQKDPDTRVAILSIQAA 404
Cdd:cd18793 11 GKLEALLELLEELREPGE-KVLIFSQFTDTLDILEEALRERGIKYLRLDGSTSSKERQKLVDRFNEDPDIRVFLLSTKAG 89
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 568908697 405 GQGLTFTAASHVVFAELYWDPGHIKQAEDRAHRIGQCSSVNIHYLI 450
Cdd:cd18793 90 GVGLNLTAANRVILYDPWWNPAVEEQAIDRAHRIGQKKPVVVYRLI 135
|
|
| DEXHc_Snf |
cd17919 |
DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting ... |
41-212 |
2.06e-35 |
|
DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting (SNF) proteins DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350677 [Multi-domain] Cd Length: 182 Bit Score: 133.07 E-value: 2.06e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 41 LLPFQKDGIVFALRRD---GRCMVADEMGLGKTIQAIAIAYFYKEE----WPLLIVVPSSLRYPWIEELEKWIPEL---- 109
Cdd:cd17919 1 LRPYQLEGLNFLLELYengPGGILADEMGLGKTLQAIAFLAYLLKEgkerGPVLVVCPLSVLENWEREFEKWTPDLrvvv 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 110 ---EPEEINVVMNKTDIGRipgSRVTVLGYGLLTTDAETLLDalntQNFRVVIVDESHYMKSRTAARSKILLPMvqKARR 186
Cdd:cd17919 81 yhgSQRERAQIRAKEKLDK---FDVVLTTYETLRRDKASLRK----FRWDLVVVDEAHRLKNPKSQLSKALKAL--RAKR 151
|
170 180
....*....|....*....|....*.
gi 568908697 187 AILLTGTPALGRPEELFMQIEALFPQ 212
Cdd:cd17919 152 RLLLTGTPLQNNLEELWALLDFLDPP 177
|
|
| SNF2-rel_dom |
pfam00176 |
SNF2-related domain; This domain is found in proteins involved in a variety of processes ... |
45-273 |
7.35e-34 |
|
SNF2-related domain; This domain is found in proteins involved in a variety of processes including transcription regulation (e.g., SNF2, STH1, brahma, MOT1), DNA repair (e.g., ERCC6, RAD16, RAD5), DNA recombination (e.g., RAD54), and chromatin unwinding (e.g., ISWI) as well as a variety of other proteins with little functional information (e.g., lodestar, ETL1). SNF2 functions as the ATPase component of the SNF2/SWI multisubunit complex, which utilizes energy derived from ATP hydrolysis to disrupt histone-DNA interactions, resulting in the increased accessibility of DNA to transcription factors.
Pssm-ID: 425504 [Multi-domain] Cd Length: 289 Bit Score: 132.04 E-value: 7.35e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 45 QKDGIVFALRRD---GR-CMVADEMGLGKTIQAIA-IAYFYKEE----WPLLIVVPSSLRYPWIEELEKWipeLEPEEIN 115
Cdd:pfam00176 2 QIEGVNWMLSLEnnlGRgGILADEMGLGKTLQTISlLLYLKHVDknwgGPTLIVVPLSLLHNWMNEFERW---VSPPALR 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 116 VVM---NKTDIGRIPGSRVTVLGYGLLTTDAETLL---DALNTQNFRVVIVDESHYMKSRTAARSKILLPMvqKARRAIL 189
Cdd:pfam00176 79 VVVlhgNKRPQERWKNDPNFLADFDVVITTYETLRkhkELLKKVHWHRIVLDEGHRLKNSKSKLSKALKSL--KTRNRWI 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 190 LTGTPALGRPEELFMQIEALFPQKFGTWIEYAKRYCNAHVRYFGKRRQWdcrgasnlsELHQLLNDIMIRRLKSEVLSQL 269
Cdd:pfam00176 157 LTGTPLQNNLEELWALLNFLRPGPFGSLSTFRNWFDRPIERGGGKKGVS---------RLHKLLKPFLLRRTKKDVEKSL 227
|
....
gi 568908697 270 PPKV 273
Cdd:pfam00176 228 PPKV 231
|
|
| DEXDc_RapA |
cd18011 |
DEXH-box helicase domain of RapA; In bacteria, RapA is an RNA polymerase (RNAP)-associated ... |
41-214 |
1.43e-28 |
|
DEXH-box helicase domain of RapA; In bacteria, RapA is an RNA polymerase (RNAP)-associated SWI2/SNF2 (switch/sucrose non-fermentable) protein that mediates RNAP recycling during transcription. The ATPase activity of RapA is stimulated by its interaction with RNAP and inhibited by its N-terminal domain. The conformational changes of RapA and its interaction with RNAP are essential for RNAP recycling. RapA is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350769 [Multi-domain] Cd Length: 207 Bit Score: 114.31 E-value: 1.43e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 41 LLPFQKDGIVFALRRD-GRCMVADEMGLGKTIQAIAIAyfyKEEW------PLLIVVPSSLRYPWIEELEK--WIPELEP 111
Cdd:cd18011 1 PLPHQIDAVLRALRKPpVRLLLADEVGLGKTIEAGLII---KELLlrgdakRVLILCPASLVEQWQDELQDkfGLPFLIL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 112 EEINVVMNKTDIGRIPGSR-VTVLGYGLLTTDaETLLDALNTQNFRVVIVDESHYMKSRTAA----RSKILLPMVQKARR 186
Cdd:cd18011 78 DRETAAQLRRLIGNPFEEFpIVIVSLDLLKRS-EERRGLLLSEEWDLVVVDEAHKLRNSGGGketkRYKLGRLLAKRARH 156
|
170 180
....*....|....*....|....*...
gi 568908697 187 AILLTGTPALGRPEELFMQIEALFPQKF 214
Cdd:cd18011 157 VLLLTATPHNGKEEDFRALLSLLDPGRF 184
|
|
| DEXQc_arch_SWI2_SNF2 |
cd18012 |
DEAQ-box helicase domain of archaeal and bacterial SNF2-related proteins; Proteins belonging ... |
37-262 |
1.05e-26 |
|
DEAQ-box helicase domain of archaeal and bacterial SNF2-related proteins; Proteins belonging to SNF2 family of DNA dependent ATPases are important members of the chromatin remodeling complexes that are implicated in epigenetic control of gene expression. The Snf2 family comprises a large group of ATP-hydrolyzing proteins that are ubiquitous in eukaryotes, but also present in eubacteria and archaea. Archaeal SWI2 and SNF2 are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350770 [Multi-domain] Cd Length: 218 Bit Score: 109.19 E-value: 1.05e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 37 LRTKLLPFQKDGI--VFALRRDG-RCMVADEMGLGKTIQAIA-IAYFYKEEW--PLLIVVPSSLRYPWIEELEKWIPELE 110
Cdd:cd18012 1 LKATLRPYQKEGFnwLSFLRHYGlGGILADDMGLGKTLQTLAlLLSRKEEGRkgPSLVVAPTSLIYNWEEEAAKFAPELK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 111 PeeinVVMNKTD-----IGRIPGSRVTVLGYGLLTTDaetlLDALNTQNFRVVIVDESHYMKSRTAARSKILlpMVQKAR 185
Cdd:cd18012 81 V----LVIHGTKrkrekLRALEDYDLVITSYGLLRRD----IELLKEVKFHYLVLDEAQNIKNPQTKTAKAV--KALKAD 150
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568908697 186 RAILLTGTPALGRPEELFMQIEALFPQKFGTWIEYAKRYCNAHVRYFGKRRqwdcrgasnLSELHQLLNDIMIRRLK 262
Cdd:cd18012 151 HRLALTGTPIENHLGELWSIFDFLNPGLLGSYKRFKKRFAKPIEKDGDEEA---------LEELKKLISPFILRRLK 218
|
|
| DEXHc_CHD6_7_8_9 |
cd17995 |
DEXH-box helicase domain of the chromodomain helicase DNA binding protein 6, 7, 8 and 9; ... |
41-260 |
6.17e-26 |
|
DEXH-box helicase domain of the chromodomain helicase DNA binding protein 6, 7, 8 and 9; Chromodomain-helicase-DNA-binding protein 6-9 (CHD6, CHD7, CHD8, and CHD9) are members of the DEAD-like helicases superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350753 [Multi-domain] Cd Length: 223 Bit Score: 107.33 E-value: 6.17e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 41 LLPFQKDG---IVFALRRDGRCMVADEMGLGKTIQAIA----IAYFYKEEWPLLIVVPSSLRYPWIEELEKWIPelepee 113
Cdd:cd17995 1 LRDYQLEGvnwLLFNWYNRRNCILADEMGLGKTIQSIAflehLYQVEGIRGPFLVIAPLSTIPNWQREFETWTD------ 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 114 INVVM-----------------NKTDIGRiPGSRV---TVlgygLLTTdAETLL---DALNTQNFRVVIVDESHYMKSRT 170
Cdd:cd17995 75 MNVVVyhgsgesrqiiqqyemyFKDAQGR-KKKGVykfDV----LITT-YEMVIadaEELRKIPWRVVVVDEAHRLKNRN 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 171 AARSKILLPMVQKARraILLTGTPALGRPEELFMQIEALFPQKFGTWIEYAKRYCnahvryfgkrrqwDCRGASNLSELH 250
Cdd:cd17995 149 SKLLQGLKKLTLEHK--LLLTGTPLQNNTEELWSLLNFLEPEKFPSSEEFLEEFG-------------DLKTAEQVEKLQ 213
|
250
....*....|
gi 568908697 251 QLLNDIMIRR 260
Cdd:cd17995 214 ALLKPYMLRR 223
|
|
| PLN03142 |
PLN03142 |
Probable chromatin-remodeling complex ATPase chain; Provisional |
60-446 |
6.19e-23 |
|
Probable chromatin-remodeling complex ATPase chain; Provisional
Pssm-ID: 215601 [Multi-domain] Cd Length: 1033 Bit Score: 106.04 E-value: 6.19e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 60 MVADEMGLGKTIQAIA-IAYFYKEE---WPLLIVVPSSLRYPWIEELEKWIPELE-------PEEINVVMNKTdigRIPG 128
Cdd:PLN03142 192 ILADEMGLGKTLQTISlLGYLHEYRgitGPHMVVAPKSTLGNWMNEIRRFCPVLRavkfhgnPEERAHQREEL---LVAG 268
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 129 srvtvlGYGLLTTDAETLL---DALNTQNFRVVIVDESHYMKSRTAARSKILLPMVQKARraILLTGTPALGRPEELFMQ 205
Cdd:PLN03142 269 ------KFDVCVTSFEMAIkekTALKRFSWRYIIIDEAHRIKNENSLLSKTMRLFSTNYR--LLITGTPLQNNLHELWAL 340
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 206 IEALFPQKFGTwieyakrycnahvryFGKRRQWDCRGASN-----LSELHQLLNDIMIRRLKSEVLSQLPPKVRQRIPFD 280
Cdd:PLN03142 341 LNFLLPEIFSS---------------AETFDEWFQISGENdqqevVQQLHKVLRPFLLRRLKSDVEKGLPPKKETILKVG 405
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 281 LPPAAVKELNASFeewQKLMRAPNSGA-----METVMGL-------------------ITRMFKQTAIAKAGAVKDYIKM 336
Cdd:PLN03142 406 MSQMQKQYYKALL---QKDLDVVNAGGerkrlLNIAMQLrkccnhpylfqgaepgppyTTGEHLVENSGKMVLLDKLLPK 482
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 337 LLQNDSlKFLVFAHHLSMLQACTEAVIESKSRYIRIDGSVPSSERIHLVNQFQKDPDTR-VAILSIQAAGQGLTFTAASH 415
Cdd:PLN03142 483 LKERDS-RVLIFSQMTRLLDILEDYLMYRGYQYCRIDGNTGGEDRDASIDAFNKPGSEKfVFLLSTRAGGLGINLATADI 561
|
410 420 430
....*....|....*....|....*....|.
gi 568908697 416 VVFAELYWDPGHIKQAEDRAHRIGQCSSVNI 446
Cdd:PLN03142 562 VILYDSDWNPQVDLQAQDRAHRIGQKKEVQV 592
|
|
| DEXHc_SMARCAD1 |
cd17998 |
DEXH-box helicase domain of SMARCAD1; SWI/SNF-related matrix-associated actin-dependent ... |
59-214 |
3.15e-22 |
|
DEXH-box helicase domain of SMARCAD1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 (SMARCAD1, also known as ATP-dependent helicase 1 or Hel1) possesses intrinsic ATP-dependent nucleosome-remodeling activity and is required for both DNA repair and heterochromatin organization. SMARCAD1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350756 [Multi-domain] Cd Length: 187 Bit Score: 95.14 E-value: 3.15e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 59 CMVADEMGLGKTIQAIA-IAYFYK--EEWPLLIVVPSSLRYPWIEELEKWIPEL----------EPEEI--NVVMNKTDI 123
Cdd:cd17998 22 GILADEMGLGKTIQVIAfLAYLKEigIPGPHLVVVPSSTLDNWLREFKRWCPSLkvepyygsqeERKHLryDILKGLEDF 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 124 GripgsrVTVLGYGLLTTDAE--TLLDalnTQNFRVVIVDESHYMKSRTAARSKILlpMVQKARRAILLTGTPALGRPEE 201
Cdd:cd17998 102 D------VIVTTYNLATSNPDdrSFFK---RLKLNYVVYDEGHMLKNMTSERYRHL--MTINANFRLLLTGTPLQNNLLE 170
|
170
....*....|...
gi 568908697 202 LFMQIEALFPQKF 214
Cdd:cd17998 171 LMSLLNFIMPKPF 183
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
33-216 |
3.13e-21 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 92.94 E-value: 3.13e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 33 LPDKLRTKLLPFQKDGIVFALRRDGRCMVADEMGLGKTIQA-IAIAYFYKEE--WPLLIVVP-SSLRYPWIEELEKWIPE 108
Cdd:smart00487 1 IEKFGFEPLRPYQKEAIEALLSGLRDVILAAPTGSGKTLAAlLPALEALKRGkgGRVLVLVPtRELAEQWAEELKKLGPS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 109 LEPEEINVV--MNKTDIGRIPGSRVTVLgygLLTTDaETLLDAL-----NTQNFRVVIVDESHYMKSRTAARS-KILLPM 180
Cdd:smart00487 81 LGLKVVGLYggDSKREQLRKLESGKTDI---LVTTP-GRLLDLLendklSLSNVDLVILDEAHRLLDGGFGDQlEKLLKL 156
|
170 180 190
....*....|....*....|....*....|....*...
gi 568908697 181 VQKARRAILLTGTPALGRPE--ELFMQIEALFPQKFGT 216
Cdd:smart00487 157 LPKNVQLLLLSATPPEEIENllELFLNDPVFIDVGFTP 194
|
|
| DEXHc_CHD1_2 |
cd17993 |
DEXH-box helicase domain of the chromodomain helicase DNA binding proteins 1 and 2, and ... |
40-260 |
4.79e-21 |
|
DEXH-box helicase domain of the chromodomain helicase DNA binding proteins 1 and 2, and similar proteins; Chromodomain-helicase-DNA-binding protein 1 (CHD1) is an ATP-dependent chromatin-remodeling factor which functions as the substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. It regulates polymerase II transcription and is also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. It is not only involved in transcription-related chromatin-remodeling, but is also required to maintain a specific chromatin configuration across the genome. CHD1 is also associated with histone deacetylase (HDAC) activity. Chromodomain-helicase-DNA-binding protein 2 (CHD2) is a DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. It is involved in myogenesis via interaction with MYOD1; it binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression. Both are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350751 [Multi-domain] Cd Length: 218 Bit Score: 92.80 E-value: 4.79e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 40 KLLPFQKDGI---VFALRRDGRCMVADEMGLGKTIQAIA-IAYFYKEEW---PLLIVVPSSLRYPWIEELEKWIPELepe 112
Cdd:cd17993 1 ELRDYQLTGLnwlAHSWCKGNNGILADEMGLGKTVQTISfLSYLFHSQQqygPFLVVVPLSTMPAWQREFAKWAPDM--- 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 113 eiNVVmnkTDIGRIpGSRVTVLGY-------------GLLTTDAETLLD--ALNTQNFRVVIVDESHYMKSRTAARSKIL 177
Cdd:cd17993 78 --NVI---VYLGDI-KSRDTIREYefyfsqtkklkfnVLLTTYEIILKDkaFLGSIKWQYLAVDEAHRLKNDESLLYEAL 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 178 LPMVQKARraILLTGTPALGRPEELFMQIEALFPQKFGTWIEYAKRYCNAHVRYfgkrrqwdcrgasnLSELHQLLNDIM 257
Cdd:cd17993 152 KEFKTNNR--LLITGTPLQNSLKELWALLHFLMPGKFDIWEEFEEEHDEEQEKG--------------IADLHKELEPFI 215
|
...
gi 568908697 258 IRR 260
Cdd:cd17993 216 LRR 218
|
|
| DEXHc_CHD2 |
cd18054 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 2; ... |
55-260 |
1.33e-20 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 2; Chromodomain-helicase-DNA-binding protein 2 (CHD2) is a DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. It is involved in myogenesis via interaction with MYOD1; it binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression. CHD2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350812 [Multi-domain] Cd Length: 237 Bit Score: 91.99 E-value: 1.33e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 55 RDGRCMVADEMGLGKTIQAIA-IAYFYKEEW---PLLIVVPSSLRYPWIEELEKWIPelepeEINVVMNKTDIgripGSR 130
Cdd:cd18054 38 KNNSVILADEMGLGKTIQTISfLSYLFHQHQlygPFLLVVPLSTLTSWQREFEIWAP-----EINVVVYIGDL----MSR 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 131 VTV------------LGYGLLTTDAETLLD---ALNTQNFRVVIVDESHYMKSRTAARSKILLPMVQKARraILLTGTPA 195
Cdd:cd18054 109 NTIreyewihsqtkrLKFNALITTYEILLKdktVLGSINWAFLGVDEAHRLKNDDSLLYKTLIDFKSNHR--LLITGTPL 186
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568908697 196 LGRPEELFMQIEALFPQKFGTWIEYAKRYcnahvryfGKRRQwdcrgaSNLSELHQLLNDIMIRR 260
Cdd:cd18054 187 QNSLKELWSLLHFIMPEKFEFWEDFEEDH--------GKGRE------NGYQSLHKVLEPFLLRR 237
|
|
| DEXHc_RAD54 |
cd18004 |
DEXH-box helicase domain of RAD54; RAD54 proteins play a role in recombination. They are ... |
41-260 |
4.37e-20 |
|
DEXH-box helicase domain of RAD54; RAD54 proteins play a role in recombination. They are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350762 [Multi-domain] Cd Length: 240 Bit Score: 90.81 E-value: 4.37e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 41 LLPFQKDGIVFALRR-------DGR-CMVADEMGLGKTIQAIAIAyfykeeWPLL--------------IVVPSSLRYPW 98
Cdd:cd18004 1 LRPHQREGVQFLYDCltgrrgyGGGgAILADEMGLGKTLQAIALV------WTLLkqgpygkptakkalIVCPSSLVGNW 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 99 IEELEKWIPE-------LEPEEINVVMNKTDIGRIPGSRVTVLGYGLLTTDAETLldaLNTQNFRVVIVDESHYMKSRTA 171
Cdd:cd18004 75 KAEFDKWLGLrrikvvtADGNAKDVKASLDFFSSASTYPVLIISYETLRRHAEKL---SKKISIDLLICDEGHRLKNSES 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 172 ARSKILLPMvqKARRAILLTGTPALGRPEELFMQIEALFPQKFGTWIEYAKRY-----------CNAHVRYFGKRRQWdc 240
Cdd:cd18004 152 KTTKALNSL--PCRRRLLLTGTPIQNDLDEFFALVDFVNPGILGSLASFRKVFeepilrsrdpdASEEDKELGAERSQ-- 227
|
250 260
....*....|....*....|
gi 568908697 241 rgasnlsELHQLLNDIMIRR 260
Cdd:cd18004 228 -------ELSELTSRFILRR 240
|
|
| DEXDc_SHPRH-like |
cd18008 |
DEXH-box helicase domain of SHPRH-like proteins; The SHPRH-like subgroup belongs to the ... |
41-260 |
6.91e-20 |
|
DEXH-box helicase domain of SHPRH-like proteins; The SHPRH-like subgroup belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350766 [Multi-domain] Cd Length: 241 Bit Score: 90.04 E-value: 6.91e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 41 LLPFQKDGIVFALRRDGrcMVADEMGLGKTIQAIA-----------IAYFYKEEWPL----------LIVVPSSLRYPWI 99
Cdd:cd18008 1 LLPYQKQGLAWMLPRGG--ILADEMGLGKTIQALAlilatrpqdpkIPEELEENSSDpkklylskttLIVVPLSLLSQWK 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 100 EELEKWIpelEPEEINVVM-----NKTDIGRIPGSRVTVLGYGLLTTD------------AETLLDALNTQNFRVVIVDE 162
Cdd:cd18008 79 DEIEKHT---KPGSLKVYVyhgskRIKSIEELSDYDIVITTYGTLASEfpknkkgggrdsKEKEASPLHRIRWYRVILDE 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 163 SHYMKSRTAARSKillpMVQ--KARRAILLTGTPALGRPEELFMQIealfpqKFGtwieyakrycnaHVRYFGKRRQWDC 240
Cdd:cd18008 156 AHNIKNRSTKTSR----AVCalKAERRWCLTGTPIQNSLDDLYSLL------RFL------------RVEPFGDYPWFNS 213
|
250 260
....*....|....*....|....*...
gi 568908697 241 RGASNLSE--------LHQLLNDIMIRR 260
Cdd:cd18008 214 DISKPFSKndrkalerLQALLKPILLRR 241
|
|
| DEXHc_ERCC6L2 |
cd18005 |
DEXH-box helicase domain of ERCC6L2; ERCC excision repair 6 like 2 (ERCC6L2, also known as ... |
41-216 |
2.45e-19 |
|
DEXH-box helicase domain of ERCC6L2; ERCC excision repair 6 like 2 (ERCC6L2, also known as RAD26L) may play a role in DNA repair and mitochondrial function. In humans, mutations in the ERCC6L2 gene are associated with bone marrow failure syndrome 2. ERCC6L2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350763 [Multi-domain] Cd Length: 245 Bit Score: 88.59 E-value: 2.45e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 41 LLPFQKDGIVFALRR--DGR-CMVADEMGLGKTIQAIAI------------------AYFYKEEW------PLLIVVPSS 93
Cdd:cd18005 1 LRDYQREGVEFMYDLykNGRgGILGDDMGLGKTVQVIAFlaavlgktgtrrdrennrPRFKKKPPassakkPVLIVAPLS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 94 LRYPWIEELEKWiPELEPEEINVVMNKtdigRIPGSRVTVLGYGLLTTDAETL---LDALNTQNFRVVIVDESHYMKSRT 170
Cdd:cd18005 81 VLYNWKDELDTW-GHFEVGVYHGSRKD----DELEGRLKAGRLEVVVTTYDTLrrcIDSLNSINWSAVIADEAHRIKNPK 155
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 568908697 171 AARSKILLPMVQKARraILLTGTPALGRPEELFMQIEALFPQKFGT 216
Cdd:cd18005 156 SKLTQAMKELKCKVR--IGLTGTLLQNNMKELWCLLDWAVPGALGS 199
|
|
| DEXQc_INO80 |
cd18002 |
DEAQ-box helicase domain of INO80; INO80 is the catalytic ATPase subunit of the INO80 ... |
60-260 |
4.47e-19 |
|
DEAQ-box helicase domain of INO80; INO80 is the catalytic ATPase subunit of the INO80 chromatin remodeling complex. INO80 removes histone H3-containing nucleosomes from associated chromatin, promotes CENP-ACnp1 chromatin assembly at the centromere in a redundant manner with another chromatin-remodeling factor Chd1Hrp1. INO80 mutants have severe defects in oxygen consumption and promiscuous cell division that is no longer coupled with metabolic status. INO80 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350760 [Multi-domain] Cd Length: 229 Bit Score: 87.56 E-value: 4.47e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 60 MVADEMGLGKTIQAIAIAYFYKEE---W-PLLIVVPSSLRYPWIEELEKWIPELE-------PEEINVVMN----KTDIG 124
Cdd:cd18002 23 ILADEMGLGKTVQSIAVLAHLAEEhniWgPFLVIAPASTLHNWQQEISRFVPQFKvlpywgnPKDRKVLRKfwdrKNLYT 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 125 RIPGSRVTVLGYGLLTTDAETlldaLNTQNFRVVIVDESHYMKSRTAARSKILLPMvqKARRAILLTGTPALGRPEELFM 204
Cdd:cd18002 103 RDAPFHVVITSYQLVVQDEKY----FQRVKWQYMVLDEAQAIKSSSSSRWKTLLSF--HCRNRLLLTGTPIQNSMAELWA 176
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568908697 205 QIEALFPQKFGTWIEYAKrycnahvrYFGKRRQWDCRGASNLSE-----LHQLLNDIMIRR 260
Cdd:cd18002 177 LLHFIMPTLFDSHDEFNE--------WFSKDIESHAENKTGLNEhqlkrLHMILKPFMLRR 229
|
|
| DEXHc_CHD3_4_5 |
cd17994 |
DEAH-box helicase domain of the chromodomain helicase DNA binding proteins 3, 4 and 5; ... |
41-260 |
4.56e-19 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding proteins 3, 4 and 5; Chromodomain-helicase-DNA-binding protein 3 (CHD3) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. It is required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity. Chromodomain-helicase-DNA-binding protein 4 (CHD4) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromodomain-helicase-DNA-binding protein 5 (CHD5) is a chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. It is thought to specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3 and plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. As a tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa. CHD3, CHD4, and CHD5 are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350752 [Multi-domain] Cd Length: 196 Bit Score: 86.34 E-value: 4.56e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 41 LLPFQKDGI---VFALRRDGRCMVADEMGLGKTIQAIAIAY-FYKE---EWPLLIVVPSSLRYPWIEELEKWIPELEpee 113
Cdd:cd17994 1 LHPYQLEGLnwlRFSWAQGTDTILADEMGLGKTIQTIVFLYsLYKEghsKGPFLVSAPLSTIINWEREFEMWAPDFY--- 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 114 inVVMnktdigrIPGSRVTVLGYGLLTTDAETlldaLNTQNFRVVIVDESHYMKSRTAARSKILlpMVQKARRAILLTGT 193
Cdd:cd17994 78 --VVT-------YVGDHVLLTSYELISIDQAI----LGSIDWAVLVVDEAHRLKNNQSKFFRIL--NSYKIGYKLLLTGT 142
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568908697 194 PALGRPEELFMQIEALFPQKFGTWIEYAKRYCNahvryFGKRRQwdcrgasnLSELHQLLNDIMIRR 260
Cdd:cd17994 143 PLQNNLEELFHLLNFLTPERFNNLQGFLEEFAD-----ISKEDQ--------IKKLHDLLGPHMLRR 196
|
|
| DEXHc_SMARCA2_SMARCA4 |
cd17996 |
DEXH-box helicase domain of SMARCA2 and SMARCA4; SWI/SNF related, matrix associated, actin ... |
62-262 |
1.20e-18 |
|
DEXH-box helicase domain of SMARCA2 and SMARCA4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, members 2 and 4 (SMARCA2 and SMARCA4) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350754 [Multi-domain] Cd Length: 233 Bit Score: 86.27 E-value: 1.20e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 62 ADEMGLGKTIQAIA-IAYFY---KEEWPLLIVVPSSLRYPWIEELEKWIPELE-------PEEinvvmNKTDIGRIPGSR 130
Cdd:cd17996 28 ADEMGLGKTIQTISlITYLMekkKNNGPYLVIVPLSTLSNWVSEFEKWAPSVSkivykgtPDV-----RKKLQSQIRAGK 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 131 VTVlgygLLTTDAETLLD--ALNTQNFRVVIVDESHYMKSRTAARSKILLPMVQkARRAILLTGTPALGRPEELFMQIEA 208
Cdd:cd17996 103 FNV----LLTTYEYIIKDkpLLSKIKWKYMIIDEGHRMKNAQSKLTQTLNTYYH-ARYRLLLTGTPLQNNLPELWALLNF 177
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 568908697 209 LFPQKFGTwIEYAKRYCNAHVRYFGKRRQWDCRGASNL---SELHQLLNDIMIRRLK 262
Cdd:cd17996 178 LLPKIFKS-CKTFEQWFNTPFANTGEQVKIELNEEETLliiRRLHKVLRPFLLRRLK 233
|
|
| DEXHc_RAD54B |
cd18066 |
DEXH-box helicase domain of RAD54B; DNA repair and recombination protein RAD54B, also known as ... |
41-224 |
2.27e-18 |
|
DEXH-box helicase domain of RAD54B; DNA repair and recombination protein RAD54B, also known as RDH54, binds to double-stranded DNA, displays ATPase activity in the presence of DNA, and may have a role in meiotic and mitotic recombination. RAD54B is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350824 [Multi-domain] Cd Length: 235 Bit Score: 85.67 E-value: 2.27e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 41 LLPFQKDGIVF------ALRRDGR--CMVADEMGLGKTIQAIAIAYFYKEEWP---------LLIVVPSSLRYPWIEELE 103
Cdd:cd18066 1 LRPHQREGIEFlyecvmGMRVNERfgAILADEMGLGKTLQCISLIWTLLRQGPyggkpvikrALIVTPGSLVKNWKKEFQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 104 KWipeLEPEEINVVMNKTD-----IGRIPGSRVTVLGYGLLTTDaetlLDALNTQNFRVVIVDESHYMKSRTAARSKILL 178
Cdd:cd18066 81 KW---LGSERIKVFTVDQDhkveeFIASPLYSVLIISYEMLLRS----LDQISKLNFDLVICDEGHRLKNTSIKTTTALT 153
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 568908697 179 PMvqKARRAILLTGTPALGRPEELFMQIEALFPQKFGTWIEYAKRY 224
Cdd:cd18066 154 SL--SCERRIILTGTPIQNDLQEFFALIDFVNPGILGSLSTYRKVY 197
|
|
| DEXHc_SMARCA1_SMARCA5 |
cd17997 |
DEAH-box helicase domain of SMARCA1 and SMARCA5; SWI/SNF related, matrix associated, actin ... |
62-262 |
6.97e-18 |
|
DEAH-box helicase domain of SMARCA1 and SMARCA5; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 and 5 (SMARCA1 and SMARCA5) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350755 [Multi-domain] Cd Length: 222 Bit Score: 83.91 E-value: 6.97e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 62 ADEMGLGKTIQAIAIAYFYKE----EWPLLIVVPSSLRYPWIEELEKWIPELepeeiNVVM---NKTDIGRIPGSRVTVL 134
Cdd:cd17997 28 ADEMGLGKTLQTISLLGYLKHykniNGPHLIIVPKSTLDNWMREFKRWCPSL-----RVVVligDKEERADIIRDVLLPG 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 135 GYGLLTTDAETLL---DALNTQNFRVVIVDESHYMKSRTAARSKILLPMVQKARraILLTGTPALGRPEELFMQIEALFP 211
Cdd:cd17997 103 KFDVCITSYEMVIkekTVLKKFNWRYIIIDEAHRIKNEKSKLSQIVRLFNSRNR--LLLTGTPLQNNLHELWALLNFLLP 180
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 568908697 212 QKFGTWIEYakrycnahvryfgkrRQW----DCRGASN--LSELHQLLNDIMIRRLK 262
Cdd:cd17997 181 DVFTSSEDF---------------DEWfnvnNCDDDNQevVQRLHKVLRPFLLRRIK 222
|
|
| DEXHc_SMARCA5 |
cd18064 |
DEAH-box helicase domain of SMARCA5; SWI/SNF related, matrix associated, actin dependent ... |
40-272 |
1.49e-17 |
|
DEAH-box helicase domain of SMARCA5; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 (SMARCA5, also called SNF2H) is the catalytic subunit of the four known chromatin-remodeling complexes: CHRAC, RSF, ACF/WCRF, and WICH. SMARCA5 plays a major role organising arrays of nucleosomes adjacent to the binding sites for the architectural transcription factor CTCF sites and acts to promote CTCF binding SMARCA5 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350822 [Multi-domain] Cd Length: 244 Bit Score: 83.56 E-value: 1.49e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 40 KLLPFQKDGI--VFALRRDG-RCMVADEMGLGKTIQAIAIAYFYKE----EWPLLIVVPSSLRYPWIEELEKWIPELepE 112
Cdd:cd18064 15 KLRDYQVRGLnwLISLYENGiNGILADEMGLGKTLQTISLLGYMKHyrniPGPHMVLVPKSTLHNWMAEFKRWVPTL--R 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 113 EINVVMNKTDIGR------IPGS-RVTVLGYGLLTTDAETlldaLNTQNFRVVIVDESHYMKSRTAARSKILLPMvqKAR 185
Cdd:cd18064 93 AVCLIGDKDQRAAfvrdvlLPGEwDVCVTSYEMLIKEKSV----FKKFNWRYLVIDEAHRIKNEKSKLSEIVREF--KTT 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 186 RAILLTGTPALGRPEELFMQIEALFPQKFGTWIEYAKrycnahvrYFGKRrqwDCRGASNLSE-LHQLLNDIMIRRLKSE 264
Cdd:cd18064 167 NRLLLTGTPLQNNLHELWALLNFLLPDVFNSAEDFDS--------WFDTN---NCLGDQKLVErLHMVLRPFLLRRIKAD 235
|
....*...
gi 568908697 265 VLSQLPPK 272
Cdd:cd18064 236 VEKSLPPK 243
|
|
| DEXHc_HELLS_SMARCA6 |
cd18009 |
DEXH-box helicase domain of HELLS; HELLS (helicase, lymphoid specific, also known as Lsh or ... |
40-262 |
4.48e-17 |
|
DEXH-box helicase domain of HELLS; HELLS (helicase, lymphoid specific, also known as Lsh or SMARCA6) is a major epigenetic regulator crucial for normal heterochromatin structure and function. HELLS is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350767 [Multi-domain] Cd Length: 236 Bit Score: 81.66 E-value: 4.48e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 40 KLLPFQKDGI--VFALRRDG-RCMVADEMGLGKTIQAIAIAYFYKEE--W-PLLIVVPSSLRYPWIEELEKWIPEL---- 109
Cdd:cd18009 3 VMRPYQLEGMewLRMLWENGiNGILADEMGLGKTIQTIALLAHLRERgvWgPFLVIAPLSTLPNWVNEFARFTPSVpvll 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 110 ------EPEEINVVMNKTDiGRIPGSRVTVLGYGLLTTDAetllDALNTQNFRVVIVDESHYMKSrtaARSKIL--LPMV 181
Cdd:cd18009 83 yhgtkeERERLRKKIMKRE-GTLQDFPVVVTSYEIAMRDR----KALQHYAWKYLIVDEGHRLKN---LNCRLIqeLKTF 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 182 QKARRaILLTGTPALGRPEELFMQIEALFPQKFGTWIEYAKRY----CNAhvRYFGKRRQWDCRGASNLSELHQLLNDIM 257
Cdd:cd18009 155 NSDNR-LLLTGTPLQNNLSELWSLLNFLLPDVFDDLSSFESWFdfssLSD--NAADISNLSEEREQNIVHMLHAILKPFL 231
|
....*
gi 568908697 258 IRRLK 262
Cdd:cd18009 232 LRRLK 236
|
|
| DEXHc_ATRX-like |
cd18007 |
DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as ... |
41-194 |
7.56e-17 |
|
DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as transcriptional regulator ATRX (also called alpha thalassemia/mental retardation syndrome X-linked and X-linked nuclear protein or XNP) which is involved in transcriptional regulation and chromatin remodeling, and ARIP4 (also called androgen receptor-interacting protein 4, RAD54 like 2 or RAD54L2) which modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. They are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350765 [Multi-domain] Cd Length: 239 Bit Score: 81.18 E-value: 7.56e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 41 LLPFQKDGIVFALRR----------DGRCMVADEMGLGKTIQAIAIAYFYKEEWPL----LIVVPSSLRYPWIEELEKWI 106
Cdd:cd18007 1 LKPHQVEGVRFLWSNlvgtdvgsdeGGGCILAHTMGLGKTLQVITFLHTYLAAAPRrsrpLVLCPASTLYNWEDEFKKWL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 107 P-ELEPEEINVVMN--KTDIGRIP--------GSrVTVLGYGL---LTTDAET---------LLDALNTQNfrVVIVDES 163
Cdd:cd18007 81 PpDLRPLLVLVSLSasKRADARLRkinkwhkeGG-VLLIGYELfrnLASNATTdprlkqefiAALLDPGPD--LLVLDEG 157
|
170 180 190
....*....|....*....|....*....|.
gi 568908697 164 HYMKSRTAARSKILlpMVQKARRAILLTGTP 194
Cdd:cd18007 158 HRLKNEKSQLSKAL--SKVKTKRRILLTGTP 186
|
|
| DEXQc_SRCAP |
cd18003 |
DEXH/Q-box helicase domain of SRCAP; Snf2-related CBP activator (SRCAP, also known as SWR1 or ... |
62-261 |
3.08e-16 |
|
DEXH/Q-box helicase domain of SRCAP; Snf2-related CBP activator (SRCAP, also known as SWR1 or DOMO1) is the core catalytic component of the multiprotein chromatin-remodeling SRCAP complex, that is necessary for the incorporation of the histone variant H2A.Z into nucleosomes. SRCAP is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350761 [Multi-domain] Cd Length: 223 Bit Score: 78.93 E-value: 3.08e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 62 ADEMGLGKTIQAIA-IAYF--YKEEW-PLLIVVPSSLRYPWIEELEKWIPEL----------EPEEINVVMNKTDigrip 127
Cdd:cd18003 25 ADEMGLGKTIQTIAlLAHLacEKGNWgPHLIVVPTSVMLNWEMEFKRWCPGFkiltyygsakERKLKRQGWMKPN----- 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 128 GSRVTVLGYGLLTTDAEtlldALNTQNFRVVIVDESHYMKSRTAARSKILLPMvqKARRAILLTGTPALGRPEELFMQIE 207
Cdd:cd18003 100 SFHVCITSYQLVVQDHQ----VFKRKKWKYLILDEAHNIKNFKSQRWQTLLNF--NTQRRLLLTGTPLQNSLMELWSLMH 173
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 568908697 208 ALFPQKFGTWIEYakrycnahvryfgkrRQWDCRGASNLSELHQLLNDIMIRRL 261
Cdd:cd18003 174 FLMPHIFQSHQEF---------------KEWFSNPLTAMSEGSQEENEELVRRL 212
|
|
| DEXHc_Mot1 |
cd17999 |
DEXH-box helicase domain of Mot1; Modifier of transcription 1 (Mot1, also known as TAF172 in ... |
41-260 |
3.97e-16 |
|
DEXH-box helicase domain of Mot1; Modifier of transcription 1 (Mot1, also known as TAF172 in eukaryotes) regulates transcription in association with TATA binding protein (TBP). Mot1, Ino80C, and NC2 function coordinately to regulate pervasive transcription in yeast and mammals. Mot1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350757 [Multi-domain] Cd Length: 232 Bit Score: 78.93 E-value: 3.97e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 41 LLPFQKDGI---VFALRRDGRCMVADEMGLGKTIQAIAIAY---------FYKEEWPLLIVVPSSLRYPWIEELEKWIPE 108
Cdd:cd17999 1 LRPYQQEGInwlAFLNKYNLHGILCDDMGLGKTLQTLCILAsdhhkransFNSENLPSLVVCPPTLVGHWVAEIKKYFPN 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 109 LEPEEINVVMNKTDIGRIPG----SRVTVLGYGLLTTDAETLLDalntQNFRVVIVDESHYMKSrtaARSKILLPMVQ-K 183
Cdd:cd17999 81 AFLKPLAYVGPPQERRRLREqgekHNVIVASYDVLRNDIEVLTK----IEWNYCVLDEGHIIKN---SKTKLSKAVKQlK 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 184 ARRAILLTGTPALGRPEELFMQIEALFPQKFGTWIEYAKRYcnahVRYFGKRRQWDC------RGASNLSELHQLLNDIM 257
Cdd:cd17999 154 ANHRLILSGTPIQNNVLELWSLFDFLMPGYLGTEKQFQRRF----LKPILASRDSKAsakeqeAGALALEALHKQVLPFL 229
|
...
gi 568908697 258 IRR 260
Cdd:cd17999 230 LRR 232
|
|
| DEXHc_CHD1 |
cd18053 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 1; ... |
59-260 |
6.06e-16 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 1; Chromodomain-helicase-DNA-binding protein 1 (CHD1) is an ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. It regulates polymerase II transcription and is also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. It is not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. CHD1 is also associated with histone deacetylase (HDAC) activity. It is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350811 [Multi-domain] Cd Length: 237 Bit Score: 78.55 E-value: 6.06e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 59 CMVADEMGLGKTIQAIA-IAYFYKEEW---PLLIVVPSSLRYPWIEELEKWIPELepeeiNVVMNKTDIGRIPGSR---- 130
Cdd:cd18053 42 CILADEMGLGKTIQTISfLNYLFHEHQlygPFLLVVPLSTLTSWQREIQTWAPQM-----NAVVYLGDINSRNMIRthew 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 131 ----VTVLGYGLLTTDAETLLDA---LNTQNFRVVIVDESHYMKSRTAARSKILLPMvqKARRAILLTGTPALGRPEELF 203
Cdd:cd18053 117 mhpqTKRLKFNILLTTYEILLKDksfLGGLNWAFIGVDEAHRLKNDDSLLYKTLIDF--KSNHRLLITGTPLQNSLKELW 194
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 568908697 204 MQIEALFPQKFGTWIEYAKRYcnahvryfGKRRQwdcrgaSNLSELHQLLNDIMIRR 260
Cdd:cd18053 195 SLLHFIMPEKFSSWEDFEEEH--------GKGRE------YGYASLHKELEPFLLRR 237
|
|
| DEXHc_CHD1L |
cd18006 |
DEAH/Q-box helicase domain of CHD1L; Chromodomain helicase DNA binding protein 1 like (CHD1L, ... |
41-260 |
8.40e-16 |
|
DEAH/Q-box helicase domain of CHD1L; Chromodomain helicase DNA binding protein 1 like (CHD1L, also known as ALC1) is involved in DNA repair by regulating chromatin relaxation following DNA damage. CHD1L is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350764 [Multi-domain] Cd Length: 216 Bit Score: 77.48 E-value: 8.40e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 41 LLPFQKDGIVFALRRDGR---CMVADEMGLGKTIQAIAI----AYFYKEEWPLLIVVPSSLRYPWIEELEKWIPELE--- 110
Cdd:cd18006 1 LRPYQLEGVNWLLQCRAEqhgCILGDEMGLGKTCQTISLlwylAGRLKLLGPFLVLCPLSVLDNWKEELNRFAPDLSvit 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 111 ---PEEINVVMNKtDIGRIPGSRVtvlgygLLTTDAETLLDA--LNTQNFRVVIVDESHYMKSRTAARSKILLPmvQKAR 185
Cdd:cd18006 81 ymgDKEKRLDLQQ-DIKSTNRFHV------LLTTYEICLKDAsfLKSFPWASLVVDEAHRLKNQNSLLHKTLSE--FSVD 151
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568908697 186 RAILLTGTPALGRPEELFMQIEALFPQKFGtwIEYAKRYcnahVRYFGKRRqwdcRGASNLSELHQLLNDIMIRR 260
Cdd:cd18006 152 FRLLLTGTPIQNSLQELYALLSFIEPNVFP--KDKLDDF----IKAYSETD----DESETVEELHLLLQPFLLRR 216
|
|
| DEXHc_RAD54A |
cd18067 |
DEXH-box helicase domain of RAD54A; DNA repair and recombination protein RAD54A, also known as ... |
41-260 |
1.71e-15 |
|
DEXH-box helicase domain of RAD54A; DNA repair and recombination protein RAD54A, also known as RAD54L or RAD54, plays a role in homologous recombination related repair of DNA double-strand breaks. RAD54A is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350825 [Multi-domain] Cd Length: 243 Bit Score: 77.51 E-value: 1.71e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 41 LLPFQKDGIVFAL-----RRDGR---CMVADEMGLGKTIQAIAIAYFYKEEWP--------LLIVVPSSLRYPWIEELEK 104
Cdd:cd18067 1 LRPHQREGVKFLYrcvtgRRIRGshgCIMADEMGLGKTLQCITLMWTLLRQSPqckpeidkAIVVSPSSLVKNWANELGK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 105 WI-PELEPEEINVVMNKTDIGRIPGS---RVTVLGYGLLTTDAETL---LDALNTQNFRVVIVDESHYMKSRTAARSKIL 177
Cdd:cd18067 81 WLgGRLQPLAIDGGSKKEIDRKLVQWasqQGRRVSTPVLIISYETFrlhVEVLQKGEVGLVICDEGHRLKNSDNQTYQAL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 178 LPMvqKARRAILLTGTPALGRPEELFMQIEALFPQKFGTWIEYAKRYCNAHVRyfG-------KRRQwdcRGASNLSELH 250
Cdd:cd18067 161 DSL--NTQRRVLLSGTPIQNDLSEYFSLVNFVNPGILGTAAEFKKNFELPILK--GrdadaseKERQ---LGEEKLQELI 233
|
250
....*....|
gi 568908697 251 QLLNDIMIRR 260
Cdd:cd18067 234 SIVNRCIIRR 243
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
334-439 |
7.15e-15 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 71.47 E-value: 7.15e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 334 IKMLLQNDSLKFLVFAHHLSMLQaCTEAVIESKSRYIRIDGSVPSSERIHLVNQFqKDPDTRVaILSIQAAGQGLTFTAA 413
Cdd:pfam00271 7 LELLKKERGGKVLIFSQTKKTLE-AELLLEKEGIKVARLHGDLSQEEREEILEDF-RKGKIDV-LVATDVAERGLDLPDV 83
|
90 100
....*....|....*....|....*.
gi 568908697 414 SHVVFAELYWDPGHIKQAEDRAHRIG 439
Cdd:pfam00271 84 DLVINYDLPWNPASYIQRIGRAGRAG 109
|
|
| DEXHc_CHD8 |
cd18060 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 8; ... |
41-260 |
7.69e-15 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 8; Chromodomain-helicase-DNA-binding protein 8 (CHD8) is a DNA helicase that acts as a chromatin remodeling factor and regulates transcription. It also acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. It suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity and of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. It also acts as a negative regulator of Wnt signaling pathway and CTNNB1-targeted gene expression. CHD8 is also involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. It also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription. CHD8 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350818 [Multi-domain] Cd Length: 222 Bit Score: 75.09 E-value: 7.69e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 41 LLPFQKDGI---VFALRRDGRCMVADEMGLGKTIQAIAI---AYFYKEEWPLLIVVPSSLRYPWIEELEKWIpelepeEI 114
Cdd:cd18060 1 LREYQLEGVnwlLFNWYNRQNCILADEMGLGKTIQSIAFlqeVYNVGIHGPFLVIAPLSTITNWEREFNTWT------EM 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 115 NVVMN-----------------KTDIGR-IPGSrvtvLGYGLLTTDAETLLD---ALNTQNFRVVIVDESHYMKSRTAar 173
Cdd:cd18060 75 NTIVYhgslasrqmiqqyemycKDSRGRlIPGA----YKFDALITTFEMILSdcpELREIEWRCVIIDEAHRLKNRNC-- 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 174 sKIL--LPMVQKARRaILLTGTPALGRPEELFMQIEALFPQKFGTWIEYakrycnahVRYFGkrrqwDCRGASNLSELHQ 251
Cdd:cd18060 149 -KLLdsLKHMDLEHK-VLLTGTPLQNTVEELFSLLHFLEPSQFPSESEF--------LKDFG-----DLKTEEQVQKLQA 213
|
....*....
gi 568908697 252 LLNDIMIRR 260
Cdd:cd18060 214 ILKPMMLRR 222
|
|
| DEXHc_SMARCA2 |
cd18063 |
DEXH-box helicase domain of SMARCA2; SWI/SNF related, matrix associated, actin dependent ... |
60-262 |
1.00e-14 |
|
DEXH-box helicase domain of SMARCA2; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 (SMARCA2, also known as brahma homolog) is a component of the BAF complex. SMARCA2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350821 [Multi-domain] Cd Length: 251 Bit Score: 75.48 E-value: 1.00e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 60 MVADEMGLGKTIQAIAIAYFYKEE----WPLLIVVPSSLRYPWIEELEKWIPELEPEEI--NVVMNKTDIGRIPGSRVTV 133
Cdd:cd18063 46 ILADEMGLGKTIQTIALITYLMEHkrlnGPYLIIVPLSTLSNWTYEFDKWAPSVVKISYkgTPAMRRSLVPQLRSGKFNV 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 134 lgygLLTTDAETLLDA--LNTQNFRVVIVDESHYMKSRTAARSKILLPMVQKARRaILLTGTPALGRPEELFMQIEALFP 211
Cdd:cd18063 126 ----LLTTYEYIIKDKhiLAKIRWKYMIVDEGHRMKNHHCKLTQVLNTHYVAPRR-ILLTGTPLQNKLPELWALLNFLLP 200
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 568908697 212 QKFGTWIEYaKRYCNAHVRYFGKRRQWDCRGAS-NLSELHQLLNDIMIRRLK 262
Cdd:cd18063 201 TIFKSCSTF-EQWFNAPFAMTGERVDLNEEETIlIIRRLHKVLRPFLLRRLK 251
|
|
| DEXHc_ERCC6 |
cd18000 |
DEXH-box helicase domain of ERCC6; ERCC excision repair 6, chromatin remodeling factor (ERCC6, ... |
41-211 |
2.06e-14 |
|
DEXH-box helicase domain of ERCC6; ERCC excision repair 6, chromatin remodeling factor (ERCC6, also known Cockayne syndrome group B (CSB), Rad26 in Saccharomyces cerevisiae, and Rhp26 in Schizosaccharomyces pombe) is a DNA-binding protein that is important in transcription-coupled excision repair. ERCC6 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350758 [Multi-domain] Cd Length: 193 Bit Score: 72.74 E-value: 2.06e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 41 LLPFQKDGIVFALRRDGRC---MVADEMGLGKTIQAIA----IAYFYKEEWPLLIVVPSSLRYPWIEELEKWIPELEpee 113
Cdd:cd18000 1 LFKYQQTGVQWLWELHCQRvggILGDEMGLGKTIQIIAflaaLHHSKLGLGPSLIVCPATVLKQWVKEFHRWWPPFR--- 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 114 iNVVMNKTDIGRIPGS------------RVTVLGYGLLTTDAETLL---DALNTQNFRVVIVDESHYMKSRTAARSKIL- 177
Cdd:cd18000 78 -VVVLHSSGSGTGSEEklgsierksqliRKVVGDGGILITTYEGFRkhkDLLLNHNWQYVILDEGHKIRNPDAEITLACk 156
|
170 180 190
....*....|....*....|....*....|....*
gi 568908697 178 -LPMVQKarraILLTGTPALGRPEELFMQIEALFP 211
Cdd:cd18000 157 qLRTPHR----LILSGTPIQNNLKELWSLFDFVFP 187
|
|
| DEXHc_ERCC6L |
cd18001 |
DEXH-box helicase domain of ERCC6L; ERCC excision repair 6 like, spindle assembly checkpoint ... |
41-194 |
3.51e-14 |
|
DEXH-box helicase domain of ERCC6L; ERCC excision repair 6 like, spindle assembly checkpoint helicase (ERCC6L, also known as RAD26L) is an essential component of the mitotic spindle assembly checkpoint, by acting as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase. ERCC6L is proposed to stimulate cancer cell proliferation by promoting cell cycle through a way of RAB31-MAPK-CDK2. ERCC6L is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350759 [Multi-domain] Cd Length: 232 Bit Score: 73.17 E-value: 3.51e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 41 LLPFQKDGI-----VFALRRDGrcMVADEMGLGKTIQAIA-IAYFYKEEW--PLLIVVPSSLRYPWIEELEKWIPELEPE 112
Cdd:cd18001 1 LYPHQREGVawlwsLHDGGKGG--ILADDMGLGKTVQICAfLSGMFDSGLikSVLVVMPTSLIPHWVKEFAKWTPGLRVK 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 113 E---INVVMNKTDIGRIPGSRVTVLG-YGLLTTDAETlLDALNTQNFR--VVIVDESHYMKSRTAARSKILLPMVQKARr 186
Cdd:cd18001 79 VfhgTSKKERERNLERIQRGGGVLLTtYGMVLSNTEQ-LSADDHDEFKwdYVILDEGHKIKNSKTKSAKSLREIPAKNR- 156
|
....*...
gi 568908697 187 aILLTGTP 194
Cdd:cd18001 157 -IILTGTP 163
|
|
| DEXHc_SMARCA4 |
cd18062 |
DEXH-box helicase domain of SMARCA4; SWI/SNF related, matrix associated, actin dependent ... |
60-262 |
1.05e-13 |
|
DEXH-box helicase domain of SMARCA4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 (SMARCA4, also known as transcription activator BRG1) is a component of the CREST-BRG1 complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. Mutation of SMARCA4 (BRG1), the ATPase of BAF (mSWI/SNF) and PBAF complexes, contributes to a range of malignancies and neurologic disorders. SMARCA4 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350820 [Multi-domain] Cd Length: 251 Bit Score: 72.38 E-value: 1.05e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 60 MVADEMGLGKTIQAIAIAYFYKE----EWPLLIVVPSSLRYPWIEELEKWIPELepeeINVVMNKTDIGR---IPGSR-- 130
Cdd:cd18062 46 ILADEMGLGKTIQTIALITYLMEhkriNGPFLIIVPLSTLSNWVYEFDKWAPSV----VKVSYKGSPAARrafVPQLRsg 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 131 ---VTVLGYGLLTTDAETLLDAlntqNFRVVIVDESHYMKSRTAARSKILLPMVQKARRaILLTGTPALGRPEELFMQIE 207
Cdd:cd18062 122 kfnVLLTTYEYIIKDKQILAKI----RWKYMIVDEGHRMKNHHCKLTQVLNTHYVAPRR-LLLTGTPLQNKLPELWALLN 196
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 568908697 208 ALFPQKFGTWIEYaKRYCNAHVRYFGKRRQWDCRGAS-NLSELHQLLNDIMIRRLK 262
Cdd:cd18062 197 FLLPTIFKSCSTF-EQWFNAPFAMTGEKVDLNEEETIlIIRRLHKVLRPFLLRRLK 251
|
|
| DEXHc_ARIP4 |
cd18069 |
DEXH-box helicase domain of ARIP4; Androgen receptor-interacting protein 4 (ARIP4, also called ... |
44-224 |
1.94e-13 |
|
DEXH-box helicase domain of ARIP4; Androgen receptor-interacting protein 4 (ARIP4, also called RAD54 like 2 or RAD54L2 ) modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. ARIP4 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350827 [Multi-domain] Cd Length: 227 Bit Score: 71.00 E-value: 1.94e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 44 FQKDGIVFALRR----DG-RCMVADEMGLGKTIQAIAIAYFYKEEWPL---LIVVPSSLRYPWIEELEKWIPelEPEEIN 115
Cdd:cd18069 11 FLYDNIIESLERykgsSGfGCILAHSMGLGKTLQVISFLDVLLRHTGAktvLAIVPVNTLQNWLSEFNKWLP--PPEALP 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 116 VVMNKTdigripgSRVTVLGYGLLTTDAETLLDA----------LNTQNFR------VVIVDESHYMKSRTAARSKILLP 179
Cdd:cd18069 89 NVRPRP-------FKVFILNDEHKTTAARAKVIEdwvkdggvllMGYEMFRlrpgpdVVICDEGHRIKNCHASTSQALKN 161
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 568908697 180 MvqKARRAILLTGTPALGRPEELFMQIEALFPQKFGTWIEYAKRY 224
Cdd:cd18069 162 I--RSRRRIVLTGYPLQNNLIEYWCMVDFVRPDFLGTRQEFSNMF 204
|
|
| DEXHc_SMARCA1 |
cd18065 |
DEAH-box helicase domain of SMARCA1; SWI/SNF related, matrix associated, actin dependent ... |
60-262 |
2.01e-13 |
|
DEAH-box helicase domain of SMARCA1; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 (SMARCA1, also called SNF2L) is a component of NURF (nucleosome-remodeling factor) and CERF (CECR2-containing-remodeling factor) complexes which promote the perturbation of chromatin structure in an ATP-dependent manner. SMARCA1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350823 [Multi-domain] Cd Length: 233 Bit Score: 71.20 E-value: 2.01e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 60 MVADEMGLGKTIQAIAIAYFYKE----EWPLLIVVPSSLRYPWIEELEKWIPELE------PEEINVVMNKTDIgrIPGS 129
Cdd:cd18065 38 ILADEMGLGKTLQTIALLGYLKHyrniPGPHMVLVPKSTLHNWMNEFKRWVPSLRavcligDKDARAAFIRDVM--MPGE 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 130 -RVTVLGYGLLTTDAETlldaLNTQNFRVVIVDESHYMKSRTAARSKILLPMvqKARRAILLTGTPALGRPEELFMQIEA 208
Cdd:cd18065 116 wDVCVTSYEMVIKEKSV----FKKFNWRYLVIDEAHRIKNEKSKLSEIVREF--KTTNRLLLTGTPLQNNLHELWALLNF 189
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 568908697 209 LFPQKFGTWIEYAKrycnahvrYFGKRrqwDCRGASNLSE-LHQLLNDIMIRRLK 262
Cdd:cd18065 190 LLPDVFNSADDFDS--------WFDTK---NCLGDQKLVErLHAVLKPFLLRRIK 233
|
|
| DEXHc_CHD5 |
cd18057 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 5; ... |
41-260 |
3.27e-13 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 5; Chromodomain-helicase-DNA-binding protein 5 (CHD5) is a chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. It is thought to specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3 and plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. As a tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa. CHD5 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350815 [Multi-domain] Cd Length: 232 Bit Score: 70.48 E-value: 3.27e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 41 LLPFQKDGI---VFALRRDGRCMVADEMGLGKTIQAIAIAY-FYKE---EWPLLIVVPSSLRYPWIEELEKWIPEL---- 109
Cdd:cd18057 1 LHPYQLEGLnwlRFSWAQGTDTILADEMGLGKTVQTIVFLYsLYKEghsKGPYLVSAPLSTIINWEREFEMWAPDFyvvt 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 110 ------------EPE---EINVVMNKTDIGRIPGS-----RVTVLGYGLLTTDAETlldaLNTQNFRVVIVDESHYMKSR 169
Cdd:cd18057 81 ytgdkesrsvirENEfsfEDNAIRSGKKVFRMKKEaqikfHVLLTSYELITIDQAI----LGSIEWACLVVDEAHRLKNN 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 170 TAARSKILLPMvqKARRAILLTGTPALGRPEELFMQIEALFPQKFGTWIEYAKRYCnahvryfgkrrqwDCRGASNLSEL 249
Cdd:cd18057 157 QSKFFRVLNSY--KIDYKLLLTGTPLQNNLEELFHLLNFLTPERFNNLEGFLEEFA-------------DISKEDQIKKL 221
|
250
....*....|.
gi 568908697 250 HQLLNDIMIRR 260
Cdd:cd18057 222 HDLLGPHMLRR 232
|
|
| DEXHc_ATRX |
cd18068 |
DEXH-box helicase domain of ATRX; Transcriptional regulator ATRX (also called alpha ... |
41-226 |
3.39e-13 |
|
DEXH-box helicase domain of ATRX; Transcriptional regulator ATRX (also called alpha thalassemia/mental retardation syndrome X-linked and X-linked nuclear protein or XNP) is involved in transcriptional regulation and chromatin remodeling. Mutations in humans cause mental retardation, X-linked, syndromic, with hypotonic facies 1 (MRXSHF1) and alpha-thalassemia myelodysplasia syndrome (ATMDS). ATRX is part of the a DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350826 [Multi-domain] Cd Length: 246 Bit Score: 70.69 E-value: 3.39e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 41 LLPFQKDGIVF-----------ALRRDGR-CMVADEMGLGKTIQAIAIAY--FYKEEWP----LLIVVPSSLRYPWIEEL 102
Cdd:cd18068 1 LKPHQVDGVQFmwdccceslkkTKKSPGSgCILAHCMGLGKTLQVVTFLHtvLLCEKLEnfsrVLVVCPLNTVLNWLNEF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 103 EKWIPELEPEEINVVMNKTDIGRIPGSR-----------VTVLGYGL---LTTD---------AETLLDALNTQNFRVVI 159
Cdd:cd18068 81 EKWQEGLKDEEKIEVNELATYKRPQERSyklqrwqeeggVMIIGYDMyriLAQErnvksreklKEIFNKALVDPGPDFVV 160
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568908697 160 VDESHYMKSRTAARSKILLPMvqKARRAILLTGTPALGRPEELFMQIEALFPQKFGTWIEYAKRYCN 226
Cdd:cd18068 161 CDEGHILKNEASAVSKAMNSI--RTKRRIVLTGTPLQNNLIEYHCMVNFVKPNLLGTIKEFRNRFVN 225
|
|
| DEXHc_CHD6 |
cd18058 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 6; ... |
59-260 |
6.08e-13 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 6; Chromodomain-helicase-DNA-binding protein 6 (CHD6) is a DNA-dependent ATPase that plays a role in chromatin remodeling. It regulates transcription by disrupting nucleosomes in a largely non-sliding manner which strongly increases the accessibility of chromatin. It activates transcription of specific genes in response to oxidative stress through interaction with NFE2L2.2 and acts as a transcriptional repressor of different viruses including influenza virus or papillomavirus. During influenza virus infection, the viral polymerase complex localizes CHD6 to inactive chromatin where it gets degraded in a proteasome independent-manner. CHD6 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350816 [Multi-domain] Cd Length: 222 Bit Score: 69.30 E-value: 6.08e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 59 CMVADEMGLGKTIQAIAIAY---FYKEEWPLLIVVPSSLRYPWIEELEKWIpelepeEIN-VVMNKTDIgripgSRVTVL 134
Cdd:cd18058 22 CILADEMGLGKTIQSITFLSeifLMGIRGPFLIIAPLSTITNWEREFRTWT------EMNaIVYHGSQI-----SRQMIQ 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 135 GY-------------------GLLTTDAETLLDA--LNTQNFRVVIVDESHYMKSRTAARSKILLPMVQKARraILLTGT 193
Cdd:cd18058 91 QYemyyrdeqgnplsgifkfqVVITTFEMILADCpeLKKINWSCVIIDEAHRLKNRNCKLLEGLKLMALEHK--VLLTGT 168
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568908697 194 PALGRPEELFMQIEALFPQKFGTWIEYAKRycnahvryFGkrrqwDCRGASNLSELHQLLNDIMIRR 260
Cdd:cd18058 169 PLQNSVEELFSLLNFLEPSQFPSETTFLEE--------FG-----DLKTEEQVKKLQSILKPMMLRR 222
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
368-439 |
6.68e-13 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 64.93 E-value: 6.68e-13
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568908697 368 RYIRIDGSVPSSERIHLVNQFQKDPdtRVAILSIQAAGQGLTFTAASHVVFAELYWDPGHIKQAEDRAHRIG 439
Cdd:smart00490 13 KVARLHGGLSQEEREEILDKFNNGK--IKVLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGRAGRAG 82
|
|
| DEXHc_CHD7 |
cd18059 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 7; ... |
41-260 |
2.01e-12 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 7; Chromodomain-helicase-DNA-binding protein 7 (CHD7) is a probable transcription regulator. It may be involved in the 45S precursor rRNA production. CHD7 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350817 [Multi-domain] Cd Length: 222 Bit Score: 67.75 E-value: 2.01e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 41 LLPFQKDGI---VFALRRDGRCMVADEMGLGKTIQAIAIAY-FYKE--EWPLLIVVPSSLRYPWIEELEKWIpelepeEI 114
Cdd:cd18059 1 LREYQLEGVnwlLFNWYNTRNCILADEMGLGKTIQSITFLYeIYLKgiHGPFLVIAPLSTIPNWEREFRTWT------EL 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 115 NVVMNKTDIG------------RIPGSRVTVLGY---GLLTTDAETLLDALNTQN--FRVVIVDESHYMKSRTAarsKIL 177
Cdd:cd18059 75 NVVVYHGSQAsrrtiqlyemyfKDPQGRVIKGSYkfhAIITTFEMILTDCPELRNipWRCVVIDEAHRLKNRNC---KLL 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 178 --LPMVQKARRaILLTGTPALGRPEELFMQIEALFPQKFGTWIEYAKRycnahvryFGkrrqwDCRGASNLSELHQLLND 255
Cdd:cd18059 152 egLKMMDLEHK-VLLTGTPLQNTVEELFSLLHFLEPSRFPSETTFMQE--------FG-----DLKTEEQVQKLQAILKP 217
|
....*
gi 568908697 256 IMIRR 260
Cdd:cd18059 218 MMLRR 222
|
|
| DEXHc_CHD4 |
cd18056 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 4; ... |
41-260 |
2.71e-12 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 4; Chromodomain-helicase-DNA-binding protein 4 (CHD4) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. CHD4 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350814 [Multi-domain] Cd Length: 232 Bit Score: 67.78 E-value: 2.71e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 41 LLPFQKDGI---VFALRRDGRCMVADEMGLGKTIQAIAIAY-FYKE---EWPLLIVVPSSLRYPWIEELEKWIPEL---- 109
Cdd:cd18056 1 LHPYQLEGLnwlRFSWAQGTDTILADEMGLGKTVQTAVFLYsLYKEghsKGPFLVSAPLSTIINWEREFEMWAPDMyvvt 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 110 ------------EPE---EINVVMNKTDIGRIPGS-----RVTVLGYGLLTTDaetlLDALNTQNFRVVIVDESHYMKSR 169
Cdd:cd18056 81 yvgdkdsraiirENEfsfEDNAIRGGKKASRMKKEasvkfHVLLTSYELITID----MAILGSIDWACLIVDEAHRLKNN 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 170 TAARSKILLPMvqKARRAILLTGTPALGRPEELFMQIEALFPQKFGTWIEYAKRYCnahvryfgkrrqwDCRGASNLSEL 249
Cdd:cd18056 157 QSKFFRVLNGY--SLQHKLLLTGTPLQNNLEELFHLLNFLTPERFHNLEGFLEEFA-------------DIAKEDQIKKL 221
|
250
....*....|.
gi 568908697 250 HQLLNDIMIRR 260
Cdd:cd18056 222 HDMLGPHMLRR 232
|
|
| DEXQc_bact_SNF2 |
cd18013 |
DEXQ-box helicase domain of bacterial SNF2 family proteins; Proteins belonging to the SNF2 ... |
43-226 |
2.99e-12 |
|
DEXQ-box helicase domain of bacterial SNF2 family proteins; Proteins belonging to the SNF2 family of DNA dependent ATPases are important members of the chromatin remodeling complexes that are implicated in epigenetic control of gene expression. The Snf2 family comprise a large group of ATP-hydrolyzing proteins that are ubiquitous in eukaryotes, but also present in eubacteria and archaea. The bacterial SNF2 present in this family are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350771 [Multi-domain] Cd Length: 218 Bit Score: 67.37 E-value: 2.99e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 43 PFQKDGIVFALRRDGRCMVADeMGLGKT---IQAIAIAYFYKEEWPLLIVVPSSL-RYPWIEELEKWipELEPEEINVVM 118
Cdd:cd18013 3 PYQKVAINFIIEHPYCGLFLD-MGLGKTvttLTALSDLQLDDFTRRVLVIAPLRVaRSTWPDEVEKW--NHLRNLTVSVA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 119 NKTDIGRIP----GSRVTVLGYGLLttdaETLLDALNTQ-NFRVVIVDESHYMKSRTAARSKILLPMVQKARRAILLTGT 193
Cdd:cd18013 80 VGTERQRSKaantPADLYVINRENL----KWLVNKSGDPwPFDMVVIDELSSFKSPRSKRFKALRKVRPVIKRLIGLTGT 155
|
170 180 190
....*....|....*....|....*....|....*
gi 568908697 194 PALGRPEELFMQIEAL-FPQKFGTWIE-YAKRYCN 226
Cdd:cd18013 156 PSPNGLMDLWAQIALLdQGERLGRSITaYRERWFD 190
|
|
| DEXHc_HLTF1_SMARC3 |
cd18071 |
DEXH-box helicase domain of HLTF1; Helicase like transcription factor (HLTF1, also known as ... |
60-204 |
3.45e-12 |
|
DEXH-box helicase domain of HLTF1; Helicase like transcription factor (HLTF1, also known as HIP116 or SMARCA3) has both helicase and E3 ubiquitin ligase activities and ATP-dependent nucleosome-remodeling activity. HLTF1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350829 [Multi-domain] Cd Length: 239 Bit Score: 67.49 E-value: 3.45e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 60 MVADEMGLGKTIQAIAIAYFYkeewPLLIVVPSSLRYPWIEELEKWIpelEPEEINVVM----NKT-DIGRIPGSRVTVL 134
Cdd:cd18071 52 ILADDMGLGKTLTTISLILAN----FTLIVCPLSVLSNWETQFEEHV---KPGQLKVYTyhggERNrDPKLLSKYDIVLT 124
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568908697 135 GYGLLTTDAETLLDA-LNTQNFRVVIVDESHYMKSRTAARSKILLPMvqKARRAILLTGTPALGRPEELFM 204
Cdd:cd18071 125 TYNTLASDFGAKGDSpLHTINWLRVVLDEGHQIRNPNAQQTKAVLNL--SSERRWVLTGTPIQNSPKDLGS 193
|
|
| DpdE |
NF041062 |
protein DpdE; |
58-200 |
2.65e-11 |
|
protein DpdE;
Pssm-ID: 468989 [Multi-domain] Cd Length: 1048 Bit Score: 68.07 E-value: 2.65e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 58 RCMVADEMGLGKTIQAIAIAYFYKEEWP---LLIVVPSSLRYPWIEELEkwipelepeeinvvmNKTDIGRIPGSRVTVL 134
Cdd:NF041062 172 RYLLADEVGLGKTIEAGLVIRQHLLDNPdarVLVLVPDALVRQWRRELR---------------DKFFLDDFPGARVRVL 236
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568908697 135 GYglltTDAETLLDalNTQNFRVVIVDESHYM-------KSRTAARSKILLPMVQKARRAILLTGTPALGRPE 200
Cdd:NF041062 237 SH----EEPERWEP--LLDAPDLLVVDEAHQLarlawsgDPPERARYRELAALAHAAPRLLLLSATPVLGNEE 303
|
|
| DEXHc_CHD3 |
cd18055 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 3; ... |
60-260 |
4.01e-11 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 3; Chromodomain-helicase-DNA-binding protein 3 (CHD3) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. It is required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity. CHD3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350813 [Multi-domain] Cd Length: 232 Bit Score: 64.26 E-value: 4.01e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 60 MVADEMGLGKTIQAIAIAY-FYKE---EWPLLIVVPSSLRYPWIEELEKWIPEL----------------EPE---EINV 116
Cdd:cd18055 23 ILADEMGLGKTIQTIVFLYsLYKEghtKGPFLVSAPLSTIINWEREFQMWAPDFyvvtytgdkdsraiirENEfsfDDNA 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 117 VMNKTDIGRIPGS-----RVTVLGYGLLTTDAetllDALNTQNFRVVIVDESHYMKSRTAARSKILLPMvqKARRAILLT 191
Cdd:cd18055 103 VKGGKKAFKMKREaqvkfHVLLTSYELVTIDQ----AALGSIRWACLVVDEAHRLKNNQSKFFRVLNGY--KIDHKLLLT 176
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568908697 192 GTPALGRPEELFMQIEALFPQKFGTWIEYAKRYCnahvryfgkrrqwDCRGASNLSELHQLLNDIMIRR 260
Cdd:cd18055 177 GTPLQNNLEELFHLLNFLTPERFNNLEGFLEEFA-------------DISKEDQIKKLHDLLGPHMLRR 232
|
|
| DEXHc_CHD9 |
cd18061 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 9; ... |
41-260 |
7.07e-11 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 9; Chromodomain-helicase-DNA-binding protein 9 (CHD9) acts as a transcriptional coactivator for PPARA and possibly other nuclear receptors. It is proposed to be a ATP-dependent chromatin remodeling protein. CHD9 has DNA-dependent ATPase activity and binds to A/T-rich DNA. It also associates with A/T-rich regulatory regions in promoters of genes that participate in the differentiation of progenitors during osteogenesis. CHD9 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350819 [Multi-domain] Cd Length: 222 Bit Score: 63.49 E-value: 7.07e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 41 LLPFQKDGIVFAL-----RRDgrCMVADEMGLGKTIQAIAIAY-FYKE--EWPLLIVVPSSLRYPWIEELEKWIpelepe 112
Cdd:cd18061 1 LREYQLEGLNWLLfnwynRRN--CILADEMGLGKTIQSITFLYeILLTgiRGPFLIIAPLSTIANWEREFRTWT------ 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 113 EINVVMNKTDI------------GRIPGSRVTVLGYGL--LTTDAETLLDA---LNTQNFRVVIVDESHYMKSRTAARSK 175
Cdd:cd18061 73 DLNVVVYHGSLisrqmiqqyemyFRDSQGRIIRGAYRFqaIITTFEMILGGcpeLNAIDWRCVIIDEAHRLKNKNCKLLE 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 176 ILLPMvqKARRAILLTGTPALGRPEELFMQIEALFPQKFGTWieyakrycNAHVRYFGkrrqwDCRGASNLSELHQLLND 255
Cdd:cd18061 153 GLKLM--NLEHKVLLTGTPLQNTVEELFSLLHFLEPLRFPSE--------STFMQEFG-----DLKTEEQVQKLQAILKP 217
|
....*
gi 568908697 256 IMIRR 260
Cdd:cd18061 218 MMLRR 222
|
|
| SSL2 |
COG1061 |
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair]; |
40-419 |
7.45e-11 |
|
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
Pssm-ID: 440681 [Multi-domain] Cd Length: 566 Bit Score: 66.20 E-value: 7.45e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 40 KLLPFQKDGI--VFALRRDG--RCMVADEMGLGKTIQAIAIAYFYKEEWPLLIVVPS-SLRYPWIEELEKWIPelepeEI 114
Cdd:COG1061 80 ELRPYQQEALeaLLAALERGggRGLVVAPTGTGKTVLALALAAELLRGKRVLVLVPRrELLEQWAEELRRFLG-----DP 154
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 115 NVVMNKTDIGRipgsRVTVLGYGLLTTDAEtlLDALNtQNFRVVIVDESHymksRTAARS-KILLPMVQKARRaILLTGT 193
Cdd:COG1061 155 LAGGGKKDSDA----PITVATYQSLARRAH--LDELG-DRFGLVIIDEAH----HAGAPSyRRILEAFPAAYR-LGLTAT 222
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 194 PAL--GRPEELFMqiealfpqkfgtwieyakrycnahvrYFGKRRQWDcrgasnlseLHQLLNDIMIRrlksevlsqlPP 271
Cdd:COG1061 223 PFRsdGREILLFL--------------------------FDGIVYEYS---------LKEAIEDGYLA----------PP 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 272 KVRQRipfdlppaavkelnasFEEWQKLMRapnsgAMETVMGLITRMFKQTAIAKAGAVKDYIKMLLQNDslKFLVFAHH 351
Cdd:COG1061 258 EYYGI----------------RVDLTDERA-----EYDALSERLREALAADAERKDKILRELLREHPDDR--KTLVFCSS 314
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568908697 352 LSMLQACTEAVIESKSRYIRIDGSVPSSERIHLVNQFQKDPDTrvAILSIQAAGQGLTFTAASHVVFA 419
Cdd:COG1061 315 VDHAEALAELLNEAGIRAAVVTGDTPKKEREEILEAFRDGELR--ILVTVDVLNEGVDVPRLDVAILL 380
|
|
| HNHc |
cd00085 |
HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic ... |
1025-1090 |
5.22e-08 |
|
HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and anaredoxins.
Pssm-ID: 238038 [Multi-domain] Cd Length: 57 Bit Score: 50.55 E-value: 5.22e-08
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568908697 1025 KSHRKSLLNAAWTAKLPLEqlnemlrnPGEGHFWQVDHIRPVyEGGGQCSLDNLQTLCTVCHKERT 1090
Cdd:cd00085 1 RSHRLVLLARDGLCPYCGK--------PGGTEGLEVDHIIPL-SDGGNNDLDNLVLLCRKCHRKKH 57
|
|
| DEXHc_RE |
cd17926 |
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family ... |
41-194 |
8.67e-08 |
|
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family is composed of helicase restriction enzymes and similar proteins such as TFIIH basal transcription factor complex helicase XPB subunit. These proteins are part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350684 [Multi-domain] Cd Length: 146 Bit Score: 52.31 E-value: 8.67e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 41 LLPFQKDGI--VFALRRDGRCMVADEMGLGKTIQAIA-IAYFYKEewPLLIVVPS-SLRYPWIEELEKWIPELEPEEINV 116
Cdd:cd17926 1 LRPYQEEALeaWLAHKNNRRGILVLPTGSGKTLTALAlIAYLKEL--RTLIVVPTdALLDQWKERFEDFLGDSSIGLIGG 78
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568908697 117 VMNKTDIGRIpgsrVTVLGYGLLTTDAETLLDALNtqNFRVVIVDESHYMKSRTAARskiLLPMVQKARRaILLTGTP 194
Cdd:cd17926 79 GKKKDFDDAN----VVVATYQSLSNLAEEEKDLFD--QFGLLIVDEAHHLPAKTFSE---ILKELNAKYR-LGLTATP 146
|
|
| McrA |
COG1403 |
5-methylcytosine-specific restriction endonuclease McrA [Defense mechanisms]; |
994-1087 |
6.03e-06 |
|
5-methylcytosine-specific restriction endonuclease McrA [Defense mechanisms];
Pssm-ID: 441013 [Multi-domain] Cd Length: 64 Bit Score: 44.97 E-value: 6.03e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 994 LRAQVFATEHGVCQHCGvdaqelflrmrdapkshrksllnaawtaklpleqlnemlrNPGEGHFWQVDHIRPVYEGGGQc 1073
Cdd:COG1403 10 LRRAVLKRDNGRCQYCG----------------------------------------RPFSGDALEVDHIIPRSRGGTD- 48
|
90
....*....|....
gi 568908697 1074 SLDNLQTLCTVCHK 1087
Cdd:COG1403 49 TWENLVLLCRRCNR 62
|
|
| HNH |
pfam01844 |
HNH endonuclease; His-Asn-His (HNH) proteins are a very common family of small nucleic ... |
1057-1092 |
7.24e-06 |
|
HNH endonuclease; His-Asn-His (HNH) proteins are a very common family of small nucleic acid-binding proteins that are generally associated with endonuclease activity.
Pssm-ID: 396422 [Multi-domain] Cd Length: 47 Bit Score: 43.88 E-value: 7.24e-06
10 20 30
....*....|....*....|....*....|....*.
gi 568908697 1057 FWQVDHIRPVYEGGGQcSLDNLQTLCTVCHKERTAQ 1092
Cdd:pfam01844 13 ALTVDHIIPLSDGGAD-DIENLILLCPSCHNKKHNR 47
|
|
| ResIII |
pfam04851 |
Type III restriction enzyme, res subunit; |
66-194 |
8.39e-06 |
|
Type III restriction enzyme, res subunit;
Pssm-ID: 398492 [Multi-domain] Cd Length: 162 Bit Score: 47.28 E-value: 8.39e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 66 GLGKTIQAIAIAYFYKEEWPL---LIVVPS-SLRYPWIEELEKWIPELEPEEINVVMNKTDIGRiPGSRVTVLGYGLLTT 141
Cdd:pfam04851 33 GSGKTLTAAKLIARLFKKGPIkkvLFLVPRkDLLEQALEEFKKFLPNYVEIGEIISGDKKDESV-DDNKIVVTTIQSLYK 111
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 568908697 142 DAETLLDALNTQNFRVVIVDESHymksRTAARS-KILLPMVQKARRaILLTGTP 194
Cdd:pfam04851 112 ALELASLELLPDFFDVIIIDEAH----RSGASSyRNILEYFKPAFL-LGLTATP 160
|
|
| DEXQc_SHPRH |
cd18070 |
DEXQ-box helicase domain of SHPRH; E3 ubiquitin-protein ligase SHPRH is a ubiquitously ... |
41-107 |
1.77e-04 |
|
DEXQ-box helicase domain of SHPRH; E3 ubiquitin-protein ligase SHPRH is a ubiquitously expressed protein that contains motifs characteristic of several DNA repair proteins, transcription factors, and helicases. SHPRH is a functional homolog of S. cerevisiae RAD5 and is involved in DNA repair. SHPRH is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350828 [Multi-domain] Cd Length: 257 Bit Score: 44.64 E-value: 1.77e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 41 LLPFQKDGIVFALRRDGrcMVADEMGLGKTIQAIAI-------------AYFYKEEWPL----------------LIVVP 91
Cdd:cd18070 1 LLPYQRRAVNWMLVPGG--ILADEMGLGKTVEVLALillhprpdndldaADDDSDEMVCcpdclvaetpvsskatLIVCP 78
|
90
....*....|....*.
gi 568908697 92 SSLRYPWIEELEKWIP 107
Cdd:cd18070 79 SAILAQWLDEINRHVP 94
|
|
| HNHc |
smart00507 |
HNH nucleases; |
1058-1086 |
2.01e-04 |
|
HNH nucleases;
Pssm-ID: 214702 [Multi-domain] Cd Length: 52 Bit Score: 40.13 E-value: 2.01e-04
10 20
....*....|....*....|....*....
gi 568908697 1058 WQVDHIRPvYEGGGQCSLDNLQTLCTVCH 1086
Cdd:smart00507 24 LEVDHIIP-LSDGGNDDLDNLVLLCPKCH 51
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
61-193 |
3.80e-04 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 42.01 E-value: 3.80e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 61 VADEMGLGKTIQA--IAIAYFYKEEWPLLIVVP-SSLRYPWIEELEKWIPELEPEEINVVMN--KTDIG-RIPGSRVTVL 134
Cdd:cd00046 6 ITAPTGSGKTLAAllAALLLLLKKGKKVLVLVPtKALALQTAERLRELFGPGIRVAVLVGGSsaEEREKnKLGDADIIIA 85
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568908697 135 GYGLLTTDAETLlDALNTQNFRVVIVDESHYMKSRTAARSKILLPMVQKAR---RAILLTGT 193
Cdd:cd00046 86 TPDMLLNLLLRE-DRLFLKDLKLIIVDEAHALLIDSRGALILDLAVRKAGLknaQVILLSAT 146
|
|
| DEXHc_viral_Ns3 |
cd17931 |
DEXH-box helicase domain of NS3 protease-helicase; NS3 is a nonstructural multifunctional ... |
66-195 |
7.33e-04 |
|
DEXH-box helicase domain of NS3 protease-helicase; NS3 is a nonstructural multifunctional protein found in pestiviruses that contains an N-terminal protease and a C-terminal helicase. The N-terminal domain is a chymotrypsin-like serine protease, which is responsible for most of the maturation cleavages of the polyprotein precursor in the cytosolic side of the endoplasmic reticulum membrane. The C-terminal domain, about two-thirds of NS3, is a helicase belonging to superfamily 2 (SF2) thought to be important for unwinding highly structured regions of the RNA genome during replication. NS3 plays an essential role in viral polyprotein processing and genome replication. NS3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350689 [Multi-domain] Cd Length: 151 Bit Score: 41.38 E-value: 7.33e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 66 GLGKTIQAIA--IAYFYKEEWPLLIVVPSSLRypwIEELEKWIPELEPEEINVVMNKTDIGRIPgsrVTVLGYGLLTtda 143
Cdd:cd17931 11 GAGKTTRVLPqiIREAIKKRLRTLVLAPTRVV---AAEMYEALRGLPIRYRTGAVKEEHGGNEI---VDYMCHGTFT--- 81
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 568908697 144 ETLLDALNTQNFRVVIVDESHYMKSRT-AARSKILLPMVQKARRAILLTGTPA 195
Cdd:cd17931 82 CRLLSPKRVPNYNLIIMDEAHFTDPASiAARGYIHTRVEMGEAAVIFMTATPP 134
|
|
| ZnF_RBZ |
smart00547 |
Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. ... |
625-647 |
1.04e-03 |
|
Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. In RanBPs, this domain binds RanGDP.
Pssm-ID: 197784 [Multi-domain] Cd Length: 25 Bit Score: 37.30 E-value: 1.04e-03
|
| PRK01297 |
PRK01297 |
ATP-dependent RNA helicase RhlB; Provisional |
323-440 |
5.57e-03 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 234938 [Multi-domain] Cd Length: 475 Bit Score: 40.67 E-value: 5.57e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908697 323 AIAKAGAVKDYIKMLLQNDSLKFLVFAHHLSMLQACTEAVIESKSRYIRIDGSVPSSERIHLVNQFqKDPDTRVAIlSIQ 402
Cdd:PRK01297 316 AVAGSDKYKLLYNLVTQNPWERVMVFANRKDEVRRIEERLVKDGINAAQLSGDVPQHKRIKTLEGF-REGKIRVLV-ATD 393
|
90 100 110
....*....|....*....|....*....|....*...
gi 568908697 403 AAGQGLTFTAASHVVFAELYWDPghikqaEDRAHRIGQ 440
Cdd:PRK01297 394 VAGRGIHIDGISHVINFTLPEDP------DDYVHRIGR 425
|
|
| |
