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Conserved domains on  [gi|568908714|ref|XP_006529479|]
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DNA annealing helicase and endonuclease ZRANB3 isoform X6 [Mus musculus]

Protein Classification

DEAD/DEAH box helicase( domain architecture ID 12785020)

DEAD/DEAH box containing ATP-dependent helicase catalyzes the unwinding of DNA or RNA

CATH:  3.40.50.300
EC:  3.6.4.-
Gene Ontology:  GO:0016887|GO:0003676|GO:0004386|GO:0005524
PubMed:  20206133|20225155

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DEXHc_HARP_SMARCAL1 cd18010
DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin ...
 41-260 7.39e-110

DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1, also known as HARP) is recruited to stalled replication forks to promote repair and helps restart replication. It plays a role in DNA repair, telomere maintenance and replication fork stability in response to DNA replication stress. Mutations cause Schimke Immunoosseous Dysplasia. SMARCAL1 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


:

Pssm-ID: 350768 [Multi-domain]  Cd Length: 213  Bit Score: 325.70  E-value: 7.39e-110
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714  41 LLPFQKDGIVFALRRDGRCMVADEMGLGKTIQAIAIAYFYKEEWPLLIVVPSSLRYPWIEELEKWIPELEPEEINVVMNK 120
Cdd:cd18010    1 LLPFQREGVCFALRRGGRVLIADEMGLGKTVQAIAIAAYYREEWPLLIVCPSSLRLTWADEIERWLPSLPPDDIQVIVKS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714 121 TDIGRIPGSRVTVLGYGLLTTDAETLLDalntQNFRVVIVDESHYMKSRTAARSKILLPMVQKARRAILLTGTPALGRPE 200
Cdd:cd18010   81 KDGLRDGDAKVVIVSYDLLRRLEKQLLA----RKFKVVICDESHYLKNSKAKRTKAALPLLKRAKRVILLSGTPALSRPI 156

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714 201 ELFMQIEALFPQKFGTWIEYAKRYCNAHvryFGKRRQWDCRGASNLSELHQLLNDIMIRR 260
Cdd:cd18010  157 ELFTQLDALDPKLFGRFHDFGRRYCAAK---QGGFGWDYSGSSNLEELHLLLLATIMIRR 213
HepA COG0553
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ...
 28-468 7.10e-94

Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];


:

Pssm-ID: 440319 [Multi-domain]  Cd Length: 682  Bit Score: 300.22  E-value: 7.10e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714  28 TQLDFLPDKLRTKLLPFQKDGIVFALRRD---GRCMVADEMGLGKTIQAIAIAYFYKEE---WPLLIVVPSSLRYPWIEE 101
Cdd:COG0553  229 EALESLPAGLKATLRPYQLEGAAWLLFLRrlgLGGLLADDMGLGKTIQALALLLELKERglaRPVLIVAPTSLVGNWQRE 308

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714 102 LEKWIPELEPEEINVVMN-KTDIGRIPGSRVTVLGYGLLTTDAETLLDalntQNFRVVIVDESHYMKSRTAARSKILlpM 180
Cdd:COG0553  309 LAKFAPGLRVLVLDGTRErAKGANPFEDADLVITSYGLLRRDIELLAA----VDWDLVILDEAQHIKNPATKRAKAV--R 382

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714 181 VQKARRAILLTGTPALGRPEELFMQIEALFPQKFGTWIEYAKRYCNAHVRYfgkrrqwdcrGASNLSELHQLLNDIMIRR 260
Cdd:COG0553  383 ALKARHRLALTGTPVENRLEELWSLLDFLNPGLLGSLKAFRERFARPIEKG----------DEEALERLRRLLRPFLLRR 452

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714 261 LKSEVLSQLPPKVRQRIPFDLPPA------AVKElnasfEEWQKLMRAPNSGAMETVMGLITRMfKQTAI---------- 324
Cdd:COG0553  453 TKEDVLKDLPEKTEETLYVELTPEqralyeAVLE-----YLRRELEGAEGIRRRGLILAALTRL-RQICShpallleega 526

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714 325 ------AKAGAVKDYIKMLLQNDSlKFLVFAHHLSMLQACTEAVIESKSRYIRIDGSVPSSERIHLVNQFQKDPDTRVAI 398
Cdd:COG0553  527 elsgrsAKLEALLELLEELLAEGE-KVLVFSQFTDTLDLLEERLEERGIEYAYLHGGTSAEERDELVDRFQEGPEAPVFL 605

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714 399 LSIQAAGQGLTFTAASHVVFAELYWDPGHIKQAEDRAHRIGQCSSVNIHYLIANGTLDSLMWAMLNRKAQ 468
Cdd:COG0553  606 ISLKAGGEGLNLTAADHVIHYDLWWNPAVEEQAIDRAHRIGQTRDVQVYKLVAEGTIEEKILELLEEKRA 675
 
Name Accession Description Interval E-value
DEXHc_HARP_SMARCAL1 cd18010
DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin ...
 41-260 7.39e-110

DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1, also known as HARP) is recruited to stalled replication forks to promote repair and helps restart replication. It plays a role in DNA repair, telomere maintenance and replication fork stability in response to DNA replication stress. Mutations cause Schimke Immunoosseous Dysplasia. SMARCAL1 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350768 [Multi-domain]  Cd Length: 213  Bit Score: 325.70  E-value: 7.39e-110
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714  41 LLPFQKDGIVFALRRDGRCMVADEMGLGKTIQAIAIAYFYKEEWPLLIVVPSSLRYPWIEELEKWIPELEPEEINVVMNK 120
Cdd:cd18010    1 LLPFQREGVCFALRRGGRVLIADEMGLGKTVQAIAIAAYYREEWPLLIVCPSSLRLTWADEIERWLPSLPPDDIQVIVKS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714 121 TDIGRIPGSRVTVLGYGLLTTDAETLLDalntQNFRVVIVDESHYMKSRTAARSKILLPMVQKARRAILLTGTPALGRPE 200
Cdd:cd18010   81 KDGLRDGDAKVVIVSYDLLRRLEKQLLA----RKFKVVICDESHYLKNSKAKRTKAALPLLKRAKRVILLSGTPALSRPI 156

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714 201 ELFMQIEALFPQKFGTWIEYAKRYCNAHvryFGKRRQWDCRGASNLSELHQLLNDIMIRR 260
Cdd:cd18010  157 ELFTQLDALDPKLFGRFHDFGRRYCAAK---QGGFGWDYSGSSNLEELHLLLLATIMIRR 213
HepA COG0553
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ...
 28-468 7.10e-94

Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];


Pssm-ID: 440319 [Multi-domain]  Cd Length: 682  Bit Score: 300.22  E-value: 7.10e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714  28 TQLDFLPDKLRTKLLPFQKDGIVFALRRD---GRCMVADEMGLGKTIQAIAIAYFYKEE---WPLLIVVPSSLRYPWIEE 101
Cdd:COG0553  229 EALESLPAGLKATLRPYQLEGAAWLLFLRrlgLGGLLADDMGLGKTIQALALLLELKERglaRPVLIVAPTSLVGNWQRE 308

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714 102 LEKWIPELEPEEINVVMN-KTDIGRIPGSRVTVLGYGLLTTDAETLLDalntQNFRVVIVDESHYMKSRTAARSKILlpM 180
Cdd:COG0553  309 LAKFAPGLRVLVLDGTRErAKGANPFEDADLVITSYGLLRRDIELLAA----VDWDLVILDEAQHIKNPATKRAKAV--R 382

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714 181 VQKARRAILLTGTPALGRPEELFMQIEALFPQKFGTWIEYAKRYCNAHVRYfgkrrqwdcrGASNLSELHQLLNDIMIRR 260
Cdd:COG0553  383 ALKARHRLALTGTPVENRLEELWSLLDFLNPGLLGSLKAFRERFARPIEKG----------DEEALERLRRLLRPFLLRR 452

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714 261 LKSEVLSQLPPKVRQRIPFDLPPA------AVKElnasfEEWQKLMRAPNSGAMETVMGLITRMfKQTAI---------- 324
Cdd:COG0553  453 TKEDVLKDLPEKTEETLYVELTPEqralyeAVLE-----YLRRELEGAEGIRRRGLILAALTRL-RQICShpallleega 526

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714 325 ------AKAGAVKDYIKMLLQNDSlKFLVFAHHLSMLQACTEAVIESKSRYIRIDGSVPSSERIHLVNQFQKDPDTRVAI 398
Cdd:COG0553  527 elsgrsAKLEALLELLEELLAEGE-KVLVFSQFTDTLDLLEERLEERGIEYAYLHGGTSAEERDELVDRFQEGPEAPVFL 605

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714 399 LSIQAAGQGLTFTAASHVVFAELYWDPGHIKQAEDRAHRIGQCSSVNIHYLIANGTLDSLMWAMLNRKAQ 468
Cdd:COG0553  606 ISLKAGGEGLNLTAADHVIHYDLWWNPAVEEQAIDRAHRIGQTRDVQVYKLVAEGTIEEKILELLEEKRA 675
SF2_C_SNF cd18793
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) ...
 325-450 6.52e-45

C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350180 [Multi-domain]  Cd Length: 135  Bit Score: 154.56  E-value: 6.52e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714 325 AKAGAVKDYIKMLLQNDSlKFLVFAHHLSMLQACTEAVIESKSRYIRIDGSVPSSERIHLVNQFQKDPDTRVAILSIQAA 404
Cdd:cd18793   11 GKLEALLELLEELREPGE-KVLIFSQFTDTLDILEEALRERGIKYLRLDGSTSSKERQKLVDRFNEDPDIRVFLLSTKAG 89

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 568908714 405 GQGLTFTAASHVVFAELYWDPGHIKQAEDRAHRIGQCSSVNIHYLI 450
Cdd:cd18793   90 GVGLNLTAANRVILYDPWWNPAVEEQAIDRAHRIGQKKPVVVYRLI 135
SNF2-rel_dom pfam00176
SNF2-related domain; This domain is found in proteins involved in a variety of processes ...
 45-273 5.32e-34

SNF2-related domain; This domain is found in proteins involved in a variety of processes including transcription regulation (e.g., SNF2, STH1, brahma, MOT1), DNA repair (e.g., ERCC6, RAD16, RAD5), DNA recombination (e.g., RAD54), and chromatin unwinding (e.g., ISWI) as well as a variety of other proteins with little functional information (e.g., lodestar, ETL1). SNF2 functions as the ATPase component of the SNF2/SWI multisubunit complex, which utilizes energy derived from ATP hydrolysis to disrupt histone-DNA interactions, resulting in the increased accessibility of DNA to transcription factors.


Pssm-ID: 425504 [Multi-domain]  Cd Length: 289  Bit Score: 130.11  E-value: 5.32e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714   45 QKDGIVFALRRD---GR-CMVADEMGLGKTIQAIA-IAYFYKEE----WPLLIVVPSSLRYPWIEELEKWipeLEPEEIN 115
Cdd:pfam00176   2 QIEGVNWMLSLEnnlGRgGILADEMGLGKTLQTISlLLYLKHVDknwgGPTLIVVPLSLLHNWMNEFERW---VSPPALR 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714  116 VVM---NKTDIGRIPGSRVTVLGYGLLTTDAETLL---DALNTQNFRVVIVDESHYMKSRTAARSKILLPMvqKARRAIL 189
Cdd:pfam00176  79 VVVlhgNKRPQERWKNDPNFLADFDVVITTYETLRkhkELLKKVHWHRIVLDEGHRLKNSKSKLSKALKSL--KTRNRWI 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714  190 LTGTPALGRPEELFMQIEALFPQKFGTWIEYAKRYCNAHVRYFGKRRQWdcrgasnlsELHQLLNDIMIRRLKSEVLSQL 269
Cdd:pfam00176 157 LTGTPLQNNLEELWALLNFLRPGPFGSLSTFRNWFDRPIERGGGKKGVS---------RLHKLLKPFLLRRTKKDVEKSL 227


                  ....
gi 568908714  270 PPKV 273
Cdd:pfam00176 228 PPKV 231
PLN03142 PLN03142
Probable chromatin-remodeling complex ATPase chain; Provisional
 60-446 2.78e-24

Probable chromatin-remodeling complex ATPase chain; Provisional


Pssm-ID: 215601 [Multi-domain]  Cd Length: 1033  Bit Score: 107.58  E-value: 2.78e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714   60 MVADEMGLGKTIQAIA-IAYFYKEE---WPLLIVVPSSLRYPWIEELEKWIPELE-------PEEINVVMNKTdigRIPG 128
Cdd:PLN03142  192 ILADEMGLGKTLQTISlLGYLHEYRgitGPHMVVAPKSTLGNWMNEIRRFCPVLRavkfhgnPEERAHQREEL---LVAG 268

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714  129 srvtvlGYGLLTTDAETLL---DALNTQNFRVVIVDESHYMKSRTAARSKILLPMVQKARraILLTGTPALGRPEELFMQ 205
Cdd:PLN03142  269 ------KFDVCVTSFEMAIkekTALKRFSWRYIIIDEAHRIKNENSLLSKTMRLFSTNYR--LLITGTPLQNNLHELWAL 340

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714  206 IEALFPQKFGTwieyakrycnahvryFGKRRQWDCRGASN-----LSELHQLLNDIMIRRLKSEVLSQLPPKvRQRIpfd 280
Cdd:PLN03142  341 LNFLLPEIFSS---------------AETFDEWFQISGENdqqevVQQLHKVLRPFLLRRLKSDVEKGLPPK-KETI--- 401

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714  281 lPPAAVKELNASFEE--WQKLMRAPNSGA-----METVMGL-------------------ITRMFKQTAIAKAGAVKDYI 334
Cdd:PLN03142  402 -LKVGMSQMQKQYYKalLQKDLDVVNAGGerkrlLNIAMQLrkccnhpylfqgaepgppyTTGEHLVENSGKMVLLDKLL 480

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714  335 KMLLQNDSlKFLVFAHHLSMLQACTEAVIESKSRYIRIDGSVPSSERIHLVNQFQKDPDTR-VAILSIQAAGQGLTFTAA 413
Cdd:PLN03142  481 PKLKERDS-RVLIFSQMTRLLDILEDYLMYRGYQYCRIDGNTGGEDRDASIDAFNKPGSEKfVFLLSTRAGGLGINLATA 559

                         410       420       430
                  ....*....|....*....|....*....|...
gi 568908714  414 SHVVFAELYWDPGHIKQAEDRAHRIGQCSSVNI 446
Cdd:PLN03142  560 DIVILYDSDWNPQVDLQAQDRAHRIGQKKEVQV 592
DEXDc smart00487
DEAD-like helicases superfamily;
33-216 2.61e-20

DEAD-like helicases superfamily;


Pssm-ID: 214692 [Multi-domain]  Cd Length: 201  Bit Score: 89.09  E-value: 2.61e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714    33 LPDKLRTKLLPFQKDGIVFALRRDGRCMVADEMGLGKTIQA-IAIAYFYKEE--WPLLIVVP-SSLRYPWIEELEKWIPE 108
Cdd:smart00487   1 IEKFGFEPLRPYQKEAIEALLSGLRDVILAAPTGSGKTLAAlLPALEALKRGkgGRVLVLVPtRELAEQWAEELKKLGPS 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714   109 LEPEEINVV--MNKTDIGRIPGSRVTVLgygLLTTDaETLLDAL-----NTQNFRVVIVDESHYMKSRTAARS-KILLPM 180
Cdd:smart00487  81 LGLKVVGLYggDSKREQLRKLESGKTDI---LVTTP-GRLLDLLendklSLSNVDLVILDEAHRLLDGGFGDQlEKLLKL 156

                          170       180       190
                   ....*....|....*....|....*....|....*...
gi 568908714   181 VQKARRAILLTGTPALGRPE--ELFMQIEALFPQKFGT 216
Cdd:smart00487 157 LPKNVQLLLLSATPPEEIENllELFLNDPVFIDVGFTP 194
Helicase_C pfam00271
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ...
 334-439 7.43e-15

Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.


Pssm-ID: 459740 [Multi-domain]  Cd Length: 109  Bit Score: 70.70  E-value: 7.43e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714  334 IKMLLQNDSLKFLVFAHHLSMLQaCTEAVIESKSRYIRIDGSVPSSERIHLVNQFqKDPDTRVaILSIQAAGQGLTFTAA 413
Cdd:pfam00271   7 LELLKKERGGKVLIFSQTKKTLE-AELLLEKEGIKVARLHGDLSQEEREEILEDF-RKGKIDV-LVATDVAERGLDLPDV 83

                          90       100
                  ....*....|....*....|....*.
gi 568908714  414 SHVVFAELYWDPGHIKQAEDRAHRIG 439
Cdd:pfam00271  84 DLVINYDLPWNPASYIQRIGRAGRAG 109
HELICc smart00490
helicase superfamily c-terminal domain;
368-439 4.43e-13

helicase superfamily c-terminal domain;


Pssm-ID: 197757 [Multi-domain]  Cd Length: 82  Bit Score: 64.54  E-value: 4.43e-13
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568908714   368 RYIRIDGSVPSSERIHLVNQFQKDPdtRVAILSIQAAGQGLTFTAASHVVFAELYWDPGHIKQAEDRAHRIG 439
Cdd:smart00490  13 KVARLHGGLSQEEREEILDKFNNGK--IKVLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGRAGRAG 82
DpdE NF041062
protein DpdE;
58-200 1.41e-11

protein DpdE;


Pssm-ID: 468989 [Multi-domain]  Cd Length: 1048  Bit Score: 67.30  E-value: 1.41e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714   58 RCMVADEMGLGKTIQAIAIAYFYKEEWP---LLIVVPSSLRYPWIEELEkwipelepeeinvvmNKTDIGRIPGSRVTVL 134
Cdd:NF041062  172 RYLLADEVGLGKTIEAGLVIRQHLLDNPdarVLVLVPDALVRQWRRELR---------------DKFFLDDFPGARVRVL 236

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568908714  135 GYglltTDAETLLDalNTQNFRVVIVDESHYM-------KSRTAARSKILLPMVQKARRAILLTGTPALGRPE 200
Cdd:NF041062  237 SH----EEPERWEP--LLDAPDLLVVDEAHQLarlawsgDPPERARYRELAALAHAAPRLLLLSATPVLGNEE 303
SSL2 COG1061
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
40-210 1.73e-10

Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];


Pssm-ID: 440681 [Multi-domain]  Cd Length: 566  Bit Score: 63.51  E-value: 1.73e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714  40 KLLPFQKDGI--VFALRRDG--RCMVADEMGLGKTIQAIAIAYFYKEEWPLLIVVPS-SLRYPWIEELEKWIPelepeEI 114
Cdd:COG1061   80 ELRPYQQEALeaLLAALERGggRGLVVAPTGTGKTVLALALAAELLRGKRVLVLVPRrELLEQWAEELRRFLG-----DP 154

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714 115 NVVMNKTDIGRipgsRVTVLGYGLLTTDAEtlLDALNtQNFRVVIVDESHymksRTAARS-KILLPMVQKARRaILLTGT 193
Cdd:COG1061  155 LAGGGKKDSDA----PITVATYQSLARRAH--LDELG-DRFGLVIIDEAH----HAGAPSyRRILEAFPAAYR-LGLTAT 222

                        170
                 ....*....|....*....
gi 568908714 194 PAL--GRPEELFMQIEALF 210
Cdd:COG1061  223 PFRsdGREILLFLFDGIVY 241
PRK01297 PRK01297
ATP-dependent RNA helicase RhlB; Provisional
 323-440 2.20e-03

ATP-dependent RNA helicase RhlB; Provisional


Pssm-ID: 234938 [Multi-domain]  Cd Length: 475  Bit Score: 40.67  E-value: 2.20e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714 323 AIAKAGAVKDYIKMLLQNDSLKFLVFAHHLSMLQACTEAVIESKSRYIRIDGSVPSSERIHLVNQFqKDPDTRVAIlSIQ 402
Cdd:PRK01297 316 AVAGSDKYKLLYNLVTQNPWERVMVFANRKDEVRRIEERLVKDGINAAQLSGDVPQHKRIKTLEGF-REGKIRVLV-ATD 393

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 568908714 403 AAGQGLTFTAASHVVFAELYWDPghikqaEDRAHRIGQ 440
Cdd:PRK01297 394 VAGRGIHIDGISHVINFTLPEDP------DDYVHRIGR 425
 
Name Accession Description Interval E-value
DEXHc_HARP_SMARCAL1 cd18010
DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin ...
 41-260 7.39e-110

DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1, also known as HARP) is recruited to stalled replication forks to promote repair and helps restart replication. It plays a role in DNA repair, telomere maintenance and replication fork stability in response to DNA replication stress. Mutations cause Schimke Immunoosseous Dysplasia. SMARCAL1 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350768 [Multi-domain]  Cd Length: 213  Bit Score: 325.70  E-value: 7.39e-110
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714  41 LLPFQKDGIVFALRRDGRCMVADEMGLGKTIQAIAIAYFYKEEWPLLIVVPSSLRYPWIEELEKWIPELEPEEINVVMNK 120
Cdd:cd18010    1 LLPFQREGVCFALRRGGRVLIADEMGLGKTVQAIAIAAYYREEWPLLIVCPSSLRLTWADEIERWLPSLPPDDIQVIVKS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714 121 TDIGRIPGSRVTVLGYGLLTTDAETLLDalntQNFRVVIVDESHYMKSRTAARSKILLPMVQKARRAILLTGTPALGRPE 200
Cdd:cd18010   81 KDGLRDGDAKVVIVSYDLLRRLEKQLLA----RKFKVVICDESHYLKNSKAKRTKAALPLLKRAKRVILLSGTPALSRPI 156

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714 201 ELFMQIEALFPQKFGTWIEYAKRYCNAHvryFGKRRQWDCRGASNLSELHQLLNDIMIRR 260
Cdd:cd18010  157 ELFTQLDALDPKLFGRFHDFGRRYCAAK---QGGFGWDYSGSSNLEELHLLLLATIMIRR 213
HepA COG0553
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ...
 28-468 7.10e-94

Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];


Pssm-ID: 440319 [Multi-domain]  Cd Length: 682  Bit Score: 300.22  E-value: 7.10e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714  28 TQLDFLPDKLRTKLLPFQKDGIVFALRRD---GRCMVADEMGLGKTIQAIAIAYFYKEE---WPLLIVVPSSLRYPWIEE 101
Cdd:COG0553  229 EALESLPAGLKATLRPYQLEGAAWLLFLRrlgLGGLLADDMGLGKTIQALALLLELKERglaRPVLIVAPTSLVGNWQRE 308

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714 102 LEKWIPELEPEEINVVMN-KTDIGRIPGSRVTVLGYGLLTTDAETLLDalntQNFRVVIVDESHYMKSRTAARSKILlpM 180
Cdd:COG0553  309 LAKFAPGLRVLVLDGTRErAKGANPFEDADLVITSYGLLRRDIELLAA----VDWDLVILDEAQHIKNPATKRAKAV--R 382

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714 181 VQKARRAILLTGTPALGRPEELFMQIEALFPQKFGTWIEYAKRYCNAHVRYfgkrrqwdcrGASNLSELHQLLNDIMIRR 260
Cdd:COG0553  383 ALKARHRLALTGTPVENRLEELWSLLDFLNPGLLGSLKAFRERFARPIEKG----------DEEALERLRRLLRPFLLRR 452

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714 261 LKSEVLSQLPPKVRQRIPFDLPPA------AVKElnasfEEWQKLMRAPNSGAMETVMGLITRMfKQTAI---------- 324
Cdd:COG0553  453 TKEDVLKDLPEKTEETLYVELTPEqralyeAVLE-----YLRRELEGAEGIRRRGLILAALTRL-RQICShpallleega 526

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714 325 ------AKAGAVKDYIKMLLQNDSlKFLVFAHHLSMLQACTEAVIESKSRYIRIDGSVPSSERIHLVNQFQKDPDTRVAI 398
Cdd:COG0553  527 elsgrsAKLEALLELLEELLAEGE-KVLVFSQFTDTLDLLEERLEERGIEYAYLHGGTSAEERDELVDRFQEGPEAPVFL 605

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714 399 LSIQAAGQGLTFTAASHVVFAELYWDPGHIKQAEDRAHRIGQCSSVNIHYLIANGTLDSLMWAMLNRKAQ 468
Cdd:COG0553  606 ISLKAGGEGLNLTAADHVIHYDLWWNPAVEEQAIDRAHRIGQTRDVQVYKLVAEGTIEEKILELLEEKRA 675
SF2_C_SNF cd18793
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) ...
 325-450 6.52e-45

C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350180 [Multi-domain]  Cd Length: 135  Bit Score: 154.56  E-value: 6.52e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714 325 AKAGAVKDYIKMLLQNDSlKFLVFAHHLSMLQACTEAVIESKSRYIRIDGSVPSSERIHLVNQFQKDPDTRVAILSIQAA 404
Cdd:cd18793   11 GKLEALLELLEELREPGE-KVLIFSQFTDTLDILEEALRERGIKYLRLDGSTSSKERQKLVDRFNEDPDIRVFLLSTKAG 89

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 568908714 405 GQGLTFTAASHVVFAELYWDPGHIKQAEDRAHRIGQCSSVNIHYLI 450
Cdd:cd18793   90 GVGLNLTAANRVILYDPWWNPAVEEQAIDRAHRIGQKKPVVVYRLI 135
DEXHc_Snf cd17919
DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting ...
 41-212 4.03e-35

DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting (SNF) proteins DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350677 [Multi-domain]  Cd Length: 182  Bit Score: 129.99  E-value: 4.03e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714  41 LLPFQKDGIVFALRRD---GRCMVADEMGLGKTIQAIAIAYFYKEE----WPLLIVVPSSLRYPWIEELEKWIPEL---- 109
Cdd:cd17919    1 LRPYQLEGLNFLLELYengPGGILADEMGLGKTLQAIAFLAYLLKEgkerGPVLVVCPLSVLENWEREFEKWTPDLrvvv 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714 110 ---EPEEINVVMNKTDIGRipgSRVTVLGYGLLTTDAETLLDalntQNFRVVIVDESHYMKSRTAARSKILLPMvqKARR 186
Cdd:cd17919   81 yhgSQRERAQIRAKEKLDK---FDVVLTTYETLRRDKASLRK----FRWDLVVVDEAHRLKNPKSQLSKALKAL--RAKR 151

                        170       180
                 ....*....|....*....|....*.
gi 568908714 187 AILLTGTPALGRPEELFMQIEALFPQ 212
Cdd:cd17919  152 RLLLTGTPLQNNLEELWALLDFLDPP 177
SNF2-rel_dom pfam00176
SNF2-related domain; This domain is found in proteins involved in a variety of processes ...
 45-273 5.32e-34

SNF2-related domain; This domain is found in proteins involved in a variety of processes including transcription regulation (e.g., SNF2, STH1, brahma, MOT1), DNA repair (e.g., ERCC6, RAD16, RAD5), DNA recombination (e.g., RAD54), and chromatin unwinding (e.g., ISWI) as well as a variety of other proteins with little functional information (e.g., lodestar, ETL1). SNF2 functions as the ATPase component of the SNF2/SWI multisubunit complex, which utilizes energy derived from ATP hydrolysis to disrupt histone-DNA interactions, resulting in the increased accessibility of DNA to transcription factors.


Pssm-ID: 425504 [Multi-domain]  Cd Length: 289  Bit Score: 130.11  E-value: 5.32e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714   45 QKDGIVFALRRD---GR-CMVADEMGLGKTIQAIA-IAYFYKEE----WPLLIVVPSSLRYPWIEELEKWipeLEPEEIN 115
Cdd:pfam00176   2 QIEGVNWMLSLEnnlGRgGILADEMGLGKTLQTISlLLYLKHVDknwgGPTLIVVPLSLLHNWMNEFERW---VSPPALR 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714  116 VVM---NKTDIGRIPGSRVTVLGYGLLTTDAETLL---DALNTQNFRVVIVDESHYMKSRTAARSKILLPMvqKARRAIL 189
Cdd:pfam00176  79 VVVlhgNKRPQERWKNDPNFLADFDVVITTYETLRkhkELLKKVHWHRIVLDEGHRLKNSKSKLSKALKSL--KTRNRWI 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714  190 LTGTPALGRPEELFMQIEALFPQKFGTWIEYAKRYCNAHVRYFGKRRQWdcrgasnlsELHQLLNDIMIRRLKSEVLSQL 269
Cdd:pfam00176 157 LTGTPLQNNLEELWALLNFLRPGPFGSLSTFRNWFDRPIERGGGKKGVS---------RLHKLLKPFLLRRTKKDVEKSL 227


                  ....
gi 568908714  270 PPKV 273
Cdd:pfam00176 228 PPKV 231
DEXDc_RapA cd18011
DEXH-box helicase domain of RapA; In bacteria, RapA is an RNA polymerase (RNAP)-associated ...
 41-214 4.76e-28

DEXH-box helicase domain of RapA; In bacteria, RapA is an RNA polymerase (RNAP)-associated SWI2/SNF2 (switch/sucrose non-fermentable) protein that mediates RNAP recycling during transcription. The ATPase activity of RapA is stimulated by its interaction with RNAP and inhibited by its N-terminal domain. The conformational changes of RapA and its interaction with RNAP are essential for RNAP recycling. RapA is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350769 [Multi-domain]  Cd Length: 207  Bit Score: 111.23  E-value: 4.76e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714  41 LLPFQKDGIVFALRRD-GRCMVADEMGLGKTIQAIAIAyfyKEEW------PLLIVVPSSLRYPWIEELEK--WIPELEP 111
Cdd:cd18011    1 PLPHQIDAVLRALRKPpVRLLLADEVGLGKTIEAGLII---KELLlrgdakRVLILCPASLVEQWQDELQDkfGLPFLIL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714 112 EEINVVMNKTDIGRIPGSR-VTVLGYGLLTTDaETLLDALNTQNFRVVIVDESHYMKSRTAA----RSKILLPMVQKARR 186
Cdd:cd18011   78 DRETAAQLRRLIGNPFEEFpIVIVSLDLLKRS-EERRGLLLSEEWDLVVVDEAHKLRNSGGGketkRYKLGRLLAKRARH 156

                        170       180
                 ....*....|....*....|....*...
gi 568908714 187 AILLTGTPALGRPEELFMQIEALFPQKF 214
Cdd:cd18011  157 VLLLTATPHNGKEEDFRALLSLLDPGRF 184
DEXQc_arch_SWI2_SNF2 cd18012
DEAQ-box helicase domain of archaeal and bacterial SNF2-related proteins; Proteins belonging ...
 37-262 2.14e-26

DEAQ-box helicase domain of archaeal and bacterial SNF2-related proteins; Proteins belonging to SNF2 family of DNA dependent ATPases are important members of the chromatin remodeling complexes that are implicated in epigenetic control of gene expression. The Snf2 family comprises a large group of ATP-hydrolyzing proteins that are ubiquitous in eukaryotes, but also present in eubacteria and archaea. Archaeal SWI2 and SNF2 are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350770 [Multi-domain]  Cd Length: 218  Bit Score: 106.88  E-value: 2.14e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714  37 LRTKLLPFQKDGI--VFALRRDG-RCMVADEMGLGKTIQAIA-IAYFYKEEW--PLLIVVPSSLRYPWIEELEKWIPELE 110
Cdd:cd18012    1 LKATLRPYQKEGFnwLSFLRHYGlGGILADDMGLGKTLQTLAlLLSRKEEGRkgPSLVVAPTSLIYNWEEEAAKFAPELK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714 111 PeeinVVMNKTD-----IGRIPGSRVTVLGYGLLTTDaetlLDALNTQNFRVVIVDESHYMKSRTAARSKILlpMVQKAR 185
Cdd:cd18012   81 V----LVIHGTKrkrekLRALEDYDLVITSYGLLRRD----IELLKEVKFHYLVLDEAQNIKNPQTKTAKAV--KALKAD 150

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568908714 186 RAILLTGTPALGRPEELFMQIEALFPQKFGTWIEYAKRYCNAHVRYFGKRRqwdcrgasnLSELHQLLNDIMIRRLK 262
Cdd:cd18012  151 HRLALTGTPIENHLGELWSIFDFLNPGLLGSYKRFKKRFAKPIEKDGDEEA---------LEELKKLISPFILRRLK 218
DEXHc_CHD6_7_8_9 cd17995
DEXH-box helicase domain of the chromodomain helicase DNA binding protein 6, 7, 8 and 9; ...
 41-260 8.83e-26

DEXH-box helicase domain of the chromodomain helicase DNA binding protein 6, 7, 8 and 9; Chromodomain-helicase-DNA-binding protein 6-9 (CHD6, CHD7, CHD8, and CHD9) are members of the DEAD-like helicases superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350753 [Multi-domain]  Cd Length: 223  Bit Score: 105.41  E-value: 8.83e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714  41 LLPFQKDG---IVFALRRDGRCMVADEMGLGKTIQAIA----IAYFYKEEWPLLIVVPSSLRYPWIEELEKWIPelepee 113
Cdd:cd17995    1 LRDYQLEGvnwLLFNWYNRRNCILADEMGLGKTIQSIAflehLYQVEGIRGPFLVIAPLSTIPNWQREFETWTD------ 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714 114 INVVM-----------------NKTDIGRiPGSRVT-----VLGYGLLTTDAETLLDAlntqNFRVVIVDESHYMKSRTA 171
Cdd:cd17995   75 MNVVVyhgsgesrqiiqqyemyFKDAQGR-KKKGVYkfdvlITTYEMVIADAEELRKI----PWRVVVVDEAHRLKNRNS 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714 172 ARSKILLPMVQKARraILLTGTPALGRPEELFMQIEALFPQKFGTWIEYAKRYCnahvryfgkrrqwDCRGASNLSELHQ 251
Cdd:cd17995  150 KLLQGLKKLTLEHK--LLLTGTPLQNNTEELWSLLNFLEPEKFPSSEEFLEEFG-------------DLKTAEQVEKLQA 214


                 ....*....
gi 568908714 252 LLNDIMIRR 260
Cdd:cd17995  215 LLKPYMLRR 223
PLN03142 PLN03142
Probable chromatin-remodeling complex ATPase chain; Provisional
 60-446 2.78e-24

Probable chromatin-remodeling complex ATPase chain; Provisional


Pssm-ID: 215601 [Multi-domain]  Cd Length: 1033  Bit Score: 107.58  E-value: 2.78e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714   60 MVADEMGLGKTIQAIA-IAYFYKEE---WPLLIVVPSSLRYPWIEELEKWIPELE-------PEEINVVMNKTdigRIPG 128
Cdd:PLN03142  192 ILADEMGLGKTLQTISlLGYLHEYRgitGPHMVVAPKSTLGNWMNEIRRFCPVLRavkfhgnPEERAHQREEL---LVAG 268

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714  129 srvtvlGYGLLTTDAETLL---DALNTQNFRVVIVDESHYMKSRTAARSKILLPMVQKARraILLTGTPALGRPEELFMQ 205
Cdd:PLN03142  269 ------KFDVCVTSFEMAIkekTALKRFSWRYIIIDEAHRIKNENSLLSKTMRLFSTNYR--LLITGTPLQNNLHELWAL 340

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714  206 IEALFPQKFGTwieyakrycnahvryFGKRRQWDCRGASN-----LSELHQLLNDIMIRRLKSEVLSQLPPKvRQRIpfd 280
Cdd:PLN03142  341 LNFLLPEIFSS---------------AETFDEWFQISGENdqqevVQQLHKVLRPFLLRRLKSDVEKGLPPK-KETI--- 401

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714  281 lPPAAVKELNASFEE--WQKLMRAPNSGA-----METVMGL-------------------ITRMFKQTAIAKAGAVKDYI 334
Cdd:PLN03142  402 -LKVGMSQMQKQYYKalLQKDLDVVNAGGerkrlLNIAMQLrkccnhpylfqgaepgppyTTGEHLVENSGKMVLLDKLL 480

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714  335 KMLLQNDSlKFLVFAHHLSMLQACTEAVIESKSRYIRIDGSVPSSERIHLVNQFQKDPDTR-VAILSIQAAGQGLTFTAA 413
Cdd:PLN03142  481 PKLKERDS-RVLIFSQMTRLLDILEDYLMYRGYQYCRIDGNTGGEDRDASIDAFNKPGSEKfVFLLSTRAGGLGINLATA 559

                         410       420       430
                  ....*....|....*....|....*....|...
gi 568908714  414 SHVVFAELYWDPGHIKQAEDRAHRIGQCSSVNI 446
Cdd:PLN03142  560 DIVILYDSDWNPQVDLQAQDRAHRIGQKKEVQV 592
DEXHc_SMARCAD1 cd17998
DEXH-box helicase domain of SMARCAD1; SWI/SNF-related matrix-associated actin-dependent ...
 59-214 2.54e-22

DEXH-box helicase domain of SMARCAD1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 (SMARCAD1, also known as ATP-dependent helicase 1 or Hel1) possesses intrinsic ATP-dependent nucleosome-remodeling activity and is required for both DNA repair and heterochromatin organization. SMARCAD1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350756 [Multi-domain]  Cd Length: 187  Bit Score: 94.37  E-value: 2.54e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714  59 CMVADEMGLGKTIQAIA-IAYFYK--EEWPLLIVVPSSLRYPWIEELEKWIPEL----------EPEEI--NVVMNKTDI 123
Cdd:cd17998   22 GILADEMGLGKTIQVIAfLAYLKEigIPGPHLVVVPSSTLDNWLREFKRWCPSLkvepyygsqeERKHLryDILKGLEDF 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714 124 GripgsrVTVLGYGLLTTDAETlLDALNTQNFRVVIVDESHYMKSRTAARSKILlpMVQKARRAILLTGTPALGRPEELF 203
Cdd:cd17998  102 D------VIVTTYNLATSNPDD-RSFFKRLKLNYVVYDEGHMLKNMTSERYRHL--MTINANFRLLLTGTPLQNNLLELM 172

                        170
                 ....*....|.
gi 568908714 204 MQIEALFPQKF 214
Cdd:cd17998  173 SLLNFIMPKPF 183
DEXHc_CHD2 cd18054
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 2; ...
 55-260 4.83e-21

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 2; Chromodomain-helicase-DNA-binding protein 2 (CHD2) is a DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. It is involved in myogenesis via interaction with MYOD1; it binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression. CHD2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350812 [Multi-domain]  Cd Length: 237  Bit Score: 91.99  E-value: 4.83e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714  55 RDGRCMVADEMGLGKTIQAIA-IAYFYKEEW---PLLIVVPSSLRYPWIEELEKWIPelepeEINVVMNKTDIgripGSR 130
Cdd:cd18054   38 KNNSVILADEMGLGKTIQTISfLSYLFHQHQlygPFLLVVPLSTLTSWQREFEIWAP-----EINVVVYIGDL----MSR 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714 131 VTV------------LGYGLLTTDAETLLD---ALNTQNFRVVIVDESHYMKSRTAARSKILLPMVQKARraILLTGTPA 195
Cdd:cd18054  109 NTIreyewihsqtkrLKFNALITTYEILLKdktVLGSINWAFLGVDEAHRLKNDDSLLYKTLIDFKSNHR--LLITGTPL 186

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568908714 196 LGRPEELFMQIEALFPQKFGTWIEYAKRYcnahvryfGKRRQwdcrgaSNLSELHQLLNDIMIRR 260
Cdd:cd18054  187 QNSLKELWSLLHFIMPEKFEFWEDFEEDH--------GKGRE------NGYQSLHKVLEPFLLRR 237
DEXHc_CHD1_2 cd17993
DEXH-box helicase domain of the chromodomain helicase DNA binding proteins 1 and 2, and ...
 40-260 9.56e-21

DEXH-box helicase domain of the chromodomain helicase DNA binding proteins 1 and 2, and similar proteins; Chromodomain-helicase-DNA-binding protein 1 (CHD1) is an ATP-dependent chromatin-remodeling factor which functions as the substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. It regulates polymerase II transcription and is also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. It is not only involved in transcription-related chromatin-remodeling, but is also required to maintain a specific chromatin configuration across the genome. CHD1 is also associated with histone deacetylase (HDAC) activity. Chromodomain-helicase-DNA-binding protein 2 (CHD2) is a DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. It is involved in myogenesis via interaction with MYOD1; it binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression. Both are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350751 [Multi-domain]  Cd Length: 218  Bit Score: 90.88  E-value: 9.56e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714  40 KLLPFQKDGI---VFALRRDGRCMVADEMGLGKTIQAIA-IAYFYKEEW---PLLIVVPSSLRYPWIEELEKWIPELepe 112
Cdd:cd17993    1 ELRDYQLTGLnwlAHSWCKGNNGILADEMGLGKTVQTISfLSYLFHSQQqygPFLVVVPLSTMPAWQREFAKWAPDM--- 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714 113 eiNVVmnkTDIGRIpGSRVTVLGY-------------GLLTTDAETLLD--ALNTQNFRVVIVDESHYMKSRTAARSKIL 177
Cdd:cd17993   78 --NVI---VYLGDI-KSRDTIREYefyfsqtkklkfnVLLTTYEIILKDkaFLGSIKWQYLAVDEAHRLKNDESLLYEAL 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714 178 LPMVQKARraILLTGTPALGRPEELFMQIEALFPQKFGTWIEYAKRYCNAHVRYfgkrrqwdcrgasnLSELHQLLNDIM 257
Cdd:cd17993  152 KEFKTNNR--LLITGTPLQNSLKELWALLHFLMPGKFDIWEEFEEEHDEEQEKG--------------IADLHKELEPFI 215


                 ...
gi 568908714 258 IRR 260
Cdd:cd17993  216 LRR 218
DEXHc_RAD54 cd18004
DEXH-box helicase domain of RAD54; RAD54 proteins play a role in recombination. They are ...
 41-260 2.16e-20

DEXH-box helicase domain of RAD54; RAD54 proteins play a role in recombination. They are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350762 [Multi-domain]  Cd Length: 240  Bit Score: 90.42  E-value: 2.16e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714  41 LLPFQKDGIVFALRR-------DGR-CMVADEMGLGKTIQAIAIAyfykeeWPLL--------------IVVPSSLRYPW 98
Cdd:cd18004    1 LRPHQREGVQFLYDCltgrrgyGGGgAILADEMGLGKTLQAIALV------WTLLkqgpygkptakkalIVCPSSLVGNW 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714  99 IEELEKWIPE-------LEPEEINVVMNKTDIGRIPGSRVTVLGYGLLTTDAETLldaLNTQNFRVVIVDESHYMKSRTA 171
Cdd:cd18004   75 KAEFDKWLGLrrikvvtADGNAKDVKASLDFFSSASTYPVLIISYETLRRHAEKL---SKKISIDLLICDEGHRLKNSES 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714 172 ARSKILLPMvqKARRAILLTGTPALGRPEELFMQIEALFPQKFGTWIEYAKRY-----------CNAHVRYFGKRRQWdc 240
Cdd:cd18004  152 KTTKALNSL--PCRRRLLLTGTPIQNDLDEFFALVDFVNPGILGSLASFRKVFeepilrsrdpdASEEDKELGAERSQ-- 227

                        250       260
                 ....*....|....*....|
gi 568908714 241 rgasnlsELHQLLNDIMIRR 260
Cdd:cd18004  228 -------ELSELTSRFILRR 240
DEXDc smart00487
DEAD-like helicases superfamily;
33-216 2.61e-20

DEAD-like helicases superfamily;


Pssm-ID: 214692 [Multi-domain]  Cd Length: 201  Bit Score: 89.09  E-value: 2.61e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714    33 LPDKLRTKLLPFQKDGIVFALRRDGRCMVADEMGLGKTIQA-IAIAYFYKEE--WPLLIVVP-SSLRYPWIEELEKWIPE 108
Cdd:smart00487   1 IEKFGFEPLRPYQKEAIEALLSGLRDVILAAPTGSGKTLAAlLPALEALKRGkgGRVLVLVPtRELAEQWAEELKKLGPS 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714   109 LEPEEINVV--MNKTDIGRIPGSRVTVLgygLLTTDaETLLDAL-----NTQNFRVVIVDESHYMKSRTAARS-KILLPM 180
Cdd:smart00487  81 LGLKVVGLYggDSKREQLRKLESGKTDI---LVTTP-GRLLDLLendklSLSNVDLVILDEAHRLLDGGFGDQlEKLLKL 156

                          170       180       190
                   ....*....|....*....|....*....|....*...
gi 568908714   181 VQKARRAILLTGTPALGRPE--ELFMQIEALFPQKFGT 216
Cdd:smart00487 157 LPKNVQLLLLSATPPEEIENllELFLNDPVFIDVGFTP 194
DEXDc_SHPRH-like cd18008
DEXH-box helicase domain of SHPRH-like proteins; The SHPRH-like subgroup belongs to the ...
 41-260 1.32e-19

DEXH-box helicase domain of SHPRH-like proteins; The SHPRH-like subgroup belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350766 [Multi-domain]  Cd Length: 241  Bit Score: 88.11  E-value: 1.32e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714  41 LLPFQKDGIVFALRRDGrcMVADEMGLGKTIQAIA-----------IAYFYKEEWPL----------LIVVPSSLRYPWI 99
Cdd:cd18008    1 LLPYQKQGLAWMLPRGG--ILADEMGLGKTIQALAlilatrpqdpkIPEELEENSSDpkklylskttLIVVPLSLLSQWK 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714 100 EELEKWIpelEPEEINVVM-----NKTDIGRIPGSRVTVLGYGLLTTD------------AETLLDALNTQNFRVVIVDE 162
Cdd:cd18008   79 DEIEKHT---KPGSLKVYVyhgskRIKSIEELSDYDIVITTYGTLASEfpknkkgggrdsKEKEASPLHRIRWYRVILDE 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714 163 SHYMKSRTAARSKillpMVQ--KARRAILLTGTPALGRPEELFMQIealfpqKFGtwieyakrycnaHVRYFGKRRQWDC 240
Cdd:cd18008  156 AHNIKNRSTKTSR----AVCalKAERRWCLTGTPIQNSLDDLYSLL------RFL------------RVEPFGDYPWFNS 213

                        250       260
                 ....*....|....*....|....*...
gi 568908714 241 RGASNLSE--------LHQLLNDIMIRR 260
Cdd:cd18008  214 DISKPFSKndrkalerLQALLKPILLRR 241
DEXHc_ERCC6L2 cd18005
DEXH-box helicase domain of ERCC6L2; ERCC excision repair 6 like 2 (ERCC6L2, also known as ...
 41-216 2.16e-19

DEXH-box helicase domain of ERCC6L2; ERCC excision repair 6 like 2 (ERCC6L2, also known as RAD26L) may play a role in DNA repair and mitochondrial function. In humans, mutations in the ERCC6L2 gene are associated with bone marrow failure syndrome 2. ERCC6L2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350763 [Multi-domain]  Cd Length: 245  Bit Score: 87.43  E-value: 2.16e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714  41 LLPFQKDGIVFALRR--DGR-CMVADEMGLGKTIQAIAI------------------AYFYKEEW------PLLIVVPSS 93
Cdd:cd18005    1 LRDYQREGVEFMYDLykNGRgGILGDDMGLGKTVQVIAFlaavlgktgtrrdrennrPRFKKKPPassakkPVLIVAPLS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714  94 LRYPWIEELEKWiPELEPEEINVVMNKtdigRIPGSRVTVLGYGLLTTDAETL---LDALNTQNFRVVIVDESHYMKSRT 170
Cdd:cd18005   81 VLYNWKDELDTW-GHFEVGVYHGSRKD----DELEGRLKAGRLEVVVTTYDTLrrcIDSLNSINWSAVIADEAHRIKNPK 155

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 568908714 171 AARSKILLPMVQKARraILLTGTPALGRPEELFMQIEALFPQKFGT 216
Cdd:cd18005  156 SKLTQAMKELKCKVR--IGLTGTLLQNNMKELWCLLDWAVPGALGS 199
DEXQc_INO80 cd18002
DEAQ-box helicase domain of INO80; INO80 is the catalytic ATPase subunit of the INO80 ...
 60-260 8.48e-19

DEAQ-box helicase domain of INO80; INO80 is the catalytic ATPase subunit of the INO80 chromatin remodeling complex. INO80 removes histone H3-containing nucleosomes from associated chromatin, promotes CENP-ACnp1 chromatin assembly at the centromere in a redundant manner with another chromatin-remodeling factor Chd1Hrp1. INO80 mutants have severe defects in oxygen consumption and promiscuous cell division that is no longer coupled with metabolic status. INO80 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350760 [Multi-domain]  Cd Length: 229  Bit Score: 85.63  E-value: 8.48e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714  60 MVADEMGLGKTIQAIAIAYFYKEE---W-PLLIVVPSSLRYPWIEELEKWIPELE-------PEEINVVMN----KTDIG 124
Cdd:cd18002   23 ILADEMGLGKTVQSIAVLAHLAEEhniWgPFLVIAPASTLHNWQQEISRFVPQFKvlpywgnPKDRKVLRKfwdrKNLYT 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714 125 RIPGSRVTVLGYGLLTTDAETlldaLNTQNFRVVIVDESHYMKSRTAARSKILLPMvqKARRAILLTGTPALGRPEELFM 204
Cdd:cd18002  103 RDAPFHVVITSYQLVVQDEKY----FQRVKWQYMVLDEAQAIKSSSSSRWKTLLSF--HCRNRLLLTGTPIQNSMAELWA 176

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568908714 205 QIEALFPQKFGTWIEYAKrycnahvrYFGKRRQWDCRGASNLSE-----LHQLLNDIMIRR 260
Cdd:cd18002  177 LLHFIMPTLFDSHDEFNE--------WFSKDIESHAENKTGLNEhqlkrLHMILKPFMLRR 229
DEXHc_CHD3_4_5 cd17994
DEAH-box helicase domain of the chromodomain helicase DNA binding proteins 3, 4 and 5; ...
 41-260 1.03e-18

DEAH-box helicase domain of the chromodomain helicase DNA binding proteins 3, 4 and 5; Chromodomain-helicase-DNA-binding protein 3 (CHD3) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. It is required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity. Chromodomain-helicase-DNA-binding protein 4 (CHD4) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromodomain-helicase-DNA-binding protein 5 (CHD5) is a chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. It is thought to specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3 and plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. As a tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa. CHD3, CHD4, and CHD5 are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350752 [Multi-domain]  Cd Length: 196  Bit Score: 84.41  E-value: 1.03e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714  41 LLPFQKDGI---VFALRRDGRCMVADEMGLGKTIQAIAIAY-FYKE---EWPLLIVVPSSLRYPWIEELEKWIPELEpee 113
Cdd:cd17994    1 LHPYQLEGLnwlRFSWAQGTDTILADEMGLGKTIQTIVFLYsLYKEghsKGPFLVSAPLSTIINWEREFEMWAPDFY--- 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714 114 inVVMnktdigrIPGSRVTVLGYGLLTTDAETlldaLNTQNFRVVIVDESHYMKSRTAARSKILLPMvqKARRAILLTGT 193
Cdd:cd17994   78 --VVT-------YVGDHVLLTSYELISIDQAI----LGSIDWAVLVVDEAHRLKNNQSKFFRILNSY--KIGYKLLLTGT 142

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568908714 194 PALGRPEELFMQIEALFPQKFGTWIEYAKRYCNahvryFGKRRQwdcrgasnLSELHQLLNDIMIRR 260
Cdd:cd17994  143 PLQNNLEELFHLLNFLTPERFNNLQGFLEEFAD-----ISKEDQ--------IKKLHDLLGPHMLRR 196
DEXHc_RAD54B cd18066
DEXH-box helicase domain of RAD54B; DNA repair and recombination protein RAD54B, also known as ...
 41-224 1.17e-18

DEXH-box helicase domain of RAD54B; DNA repair and recombination protein RAD54B, also known as RDH54, binds to double-stranded DNA, displays ATPase activity in the presence of DNA, and may have a role in meiotic and mitotic recombination. RAD54B is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350824 [Multi-domain]  Cd Length: 235  Bit Score: 85.28  E-value: 1.17e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714  41 LLPFQKDGIVF------ALRRDGR--CMVADEMGLGKTIQAIAIAYFYKEEWP---------LLIVVPSSLRYPWIEELE 103
Cdd:cd18066    1 LRPHQREGIEFlyecvmGMRVNERfgAILADEMGLGKTLQCISLIWTLLRQGPyggkpvikrALIVTPGSLVKNWKKEFQ 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714 104 KWipeLEPEEINVVMNKTD-----IGRIPGSRVTVLGYGLLTTDaetlLDALNTQNFRVVIVDESHYMKSRTAARSKILL 178
Cdd:cd18066   81 KW---LGSERIKVFTVDQDhkveeFIASPLYSVLIISYEMLLRS----LDQISKLNFDLVICDEGHRLKNTSIKTTTALT 153

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 568908714 179 PMvqKARRAILLTGTPALGRPEELFMQIEALFPQKFGTWIEYAKRY 224
Cdd:cd18066  154 SL--SCERRIILTGTPIQNDLQEFFALIDFVNPGILGSLSTYRKVY 197
DEXHc_SMARCA2_SMARCA4 cd17996
DEXH-box helicase domain of SMARCA2 and SMARCA4; SWI/SNF related, matrix associated, actin ...
 62-262 3.02e-18

DEXH-box helicase domain of SMARCA2 and SMARCA4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, members 2 and 4 (SMARCA2 and SMARCA4) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350754 [Multi-domain]  Cd Length: 233  Bit Score: 83.96  E-value: 3.02e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714  62 ADEMGLGKTIQAIA-IAYFY---KEEWPLLIVVPSSLRYPWIEELEKWIPELE-------PEEinvvmNKTDIGRIPGSR 130
Cdd:cd17996   28 ADEMGLGKTIQTISlITYLMekkKNNGPYLVIVPLSTLSNWVSEFEKWAPSVSkivykgtPDV-----RKKLQSQIRAGK 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714 131 VTVlgygLLTTDAETLLD--ALNTQNFRVVIVDESHYMKSRTAARSKILLPMVQkARRAILLTGTPALGRPEELFMQIEA 208
Cdd:cd17996  103 FNV----LLTTYEYIIKDkpLLSKIKWKYMIIDEGHRMKNAQSKLTQTLNTYYH-ARYRLLLTGTPLQNNLPELWALLNF 177

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 568908714 209 LFPQKFGTwIEYAKRYCNAHVRYFGKRRQWDCRGASNL---SELHQLLNDIMIRRLK 262
Cdd:cd17996  178 LLPKIFKS-CKTFEQWFNTPFANTGEQVKIELNEEETLliiRRLHKVLRPFLLRRLK 233
DEXHc_SMARCA5 cd18064
DEAH-box helicase domain of SMARCA5; SWI/SNF related, matrix associated, actin dependent ...
 40-272 8.81e-18

DEAH-box helicase domain of SMARCA5; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 (SMARCA5, also called SNF2H) is the catalytic subunit of the four known chromatin-remodeling complexes: CHRAC, RSF, ACF/WCRF, and WICH. SMARCA5 plays a major role organising arrays of nucleosomes adjacent to the binding sites for the architectural transcription factor CTCF sites and acts to promote CTCF binding SMARCA5 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350822 [Multi-domain]  Cd Length: 244  Bit Score: 82.79  E-value: 8.81e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714  40 KLLPFQKDGI--VFALRRDG-RCMVADEMGLGKTIQAIAIAYFYKE----EWPLLIVVPSSLRYPWIEELEKWIPELepE 112
Cdd:cd18064   15 KLRDYQVRGLnwLISLYENGiNGILADEMGLGKTLQTISLLGYMKHyrniPGPHMVLVPKSTLHNWMAEFKRWVPTL--R 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714 113 EINVVMNKTDIGR------IPGS-RVTVLGYGLLTTDAETlldaLNTQNFRVVIVDESHYMKSRTAARSKILLPMvqKAR 185
Cdd:cd18064   93 AVCLIGDKDQRAAfvrdvlLPGEwDVCVTSYEMLIKEKSV----FKKFNWRYLVIDEAHRIKNEKSKLSEIVREF--KTT 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714 186 RAILLTGTPALGRPEELFMQIEALFPQKFGTWIEYAKrycnahvrYFGKRrqwDCRGASNLSE-LHQLLNDIMIRRLKSE 264
Cdd:cd18064  167 NRLLLTGTPLQNNLHELWALLNFLLPDVFNSAEDFDS--------WFDTN---NCLGDQKLVErLHMVLRPFLLRRIKAD 235


                 ....*...
gi 568908714 265 VLSQLPPK 272
Cdd:cd18064  236 VEKSLPPK 243
DEXHc_SMARCA1_SMARCA5 cd17997
DEAH-box helicase domain of SMARCA1 and SMARCA5; SWI/SNF related, matrix associated, actin ...
 62-262 1.15e-17

DEAH-box helicase domain of SMARCA1 and SMARCA5; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 and 5 (SMARCA1 and SMARCA5) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350755 [Multi-domain]  Cd Length: 222  Bit Score: 81.98  E-value: 1.15e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714  62 ADEMGLGKTIQAIAIAYFYKE----EWPLLIVVPSSLRYPWIEELEKWIPELepeeiNVVM---NKTDIGRIPGSRVTVL 134
Cdd:cd17997   28 ADEMGLGKTLQTISLLGYLKHykniNGPHLIIVPKSTLDNWMREFKRWCPSL-----RVVVligDKEERADIIRDVLLPG 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714 135 GYGLLTTDAETLL---DALNTQNFRVVIVDESHYMKSRTAARSKILLPMVQKARraILLTGTPALGRPEELFMQIEALFP 211
Cdd:cd17997  103 KFDVCITSYEMVIkekTVLKKFNWRYIIIDEAHRIKNEKSKLSQIVRLFNSRNR--LLLTGTPLQNNLHELWALLNFLLP 180

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 568908714 212 QKFGTWIEYakrycnahvryfgkrRQW----DCRGASN--LSELHQLLNDIMIRRLK 262
Cdd:cd17997  181 DVFTSSEDF---------------DEWfnvnNCDDDNQevVQRLHKVLRPFLLRRIK 222
DEXHc_HELLS_SMARCA6 cd18009
DEXH-box helicase domain of HELLS; HELLS (helicase, lymphoid specific, also known as Lsh or ...
 40-262 7.59e-17

DEXH-box helicase domain of HELLS; HELLS (helicase, lymphoid specific, also known as Lsh or SMARCA6) is a major epigenetic regulator crucial for normal heterochromatin structure and function. HELLS is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350767 [Multi-domain]  Cd Length: 236  Bit Score: 79.74  E-value: 7.59e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714  40 KLLPFQKDGI--VFALRRDG-RCMVADEMGLGKTIQAIAIAYFYKEE--W-PLLIVVPSSLRYPWIEELEKWIPEL---- 109
Cdd:cd18009    3 VMRPYQLEGMewLRMLWENGiNGILADEMGLGKTIQTIALLAHLRERgvWgPFLVIAPLSTLPNWVNEFARFTPSVpvll 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714 110 ------EPEEINVVMNKTDiGRIPGSRVTVLGYGLLTTDAetllDALNTQNFRVVIVDESHYMKSrtaARSKIL--LPMV 181
Cdd:cd18009   83 yhgtkeERERLRKKIMKRE-GTLQDFPVVVTSYEIAMRDR----KALQHYAWKYLIVDEGHRLKN---LNCRLIqeLKTF 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714 182 QKARRaILLTGTPALGRPEELFMQIEALFPQKFGTWIEYAKRY----CNAhvRYFGKRRQWDCRGASNLSELHQLLNDIM 257
Cdd:cd18009  155 NSDNR-LLLTGTPLQNNLSELWSLLNFLLPDVFDDLSSFESWFdfssLSD--NAADISNLSEEREQNIVHMLHAILKPFL 231


                 ....*
gi 568908714 258 IRRLK 262
Cdd:cd18009  232 LRRLK 236
DEXHc_ATRX-like cd18007
DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as ...
 41-194 1.23e-16

DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as transcriptional regulator ATRX (also called alpha thalassemia/mental retardation syndrome X-linked and X-linked nuclear protein or XNP) which is involved in transcriptional regulation and chromatin remodeling, and ARIP4 (also called androgen receptor-interacting protein 4, RAD54 like 2 or RAD54L2) which modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. They are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350765 [Multi-domain]  Cd Length: 239  Bit Score: 79.26  E-value: 1.23e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714  41 LLPFQKDGIVFALRR----------DGRCMVADEMGLGKTIQAIAIAYFYKEEWPL----LIVVPSSLRYPWIEELEKWI 106
Cdd:cd18007    1 LKPHQVEGVRFLWSNlvgtdvgsdeGGGCILAHTMGLGKTLQVITFLHTYLAAAPRrsrpLVLCPASTLYNWEDEFKKWL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714 107 P-ELEPEEINVVMN--KTDIGRIP--------GSrVTVLGYGL---LTTDAETLLDALNTQNFR-------VVIVDESHY 165
Cdd:cd18007   81 PpDLRPLLVLVSLSasKRADARLRkinkwhkeGG-VLLIGYELfrnLASNATTDPRLKQEFIAAlldpgpdLLVLDEGHR 159

                        170       180
                 ....*....|....*....|....*....
gi 568908714 166 MKSRTAARSKILlpMVQKARRAILLTGTP 194
Cdd:cd18007  160 LKNEKSQLSKAL--SKVKTKRRILLTGTP 186
DEXHc_Mot1 cd17999
DEXH-box helicase domain of Mot1; Modifier of transcription 1 (Mot1, also known as TAF172 in ...
 41-260 3.03e-16

DEXH-box helicase domain of Mot1; Modifier of transcription 1 (Mot1, also known as TAF172 in eukaryotes) regulates transcription in association with TATA binding protein (TBP). Mot1, Ino80C, and NC2 function coordinately to regulate pervasive transcription in yeast and mammals. Mot1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350757 [Multi-domain]  Cd Length: 232  Bit Score: 78.16  E-value: 3.03e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714  41 LLPFQKDGI---VFALRRDGRCMVADEMGLGKTIQAIAIAY---------FYKEEWPLLIVVPSSLRYPWIEELEKWIPE 108
Cdd:cd17999    1 LRPYQQEGInwlAFLNKYNLHGILCDDMGLGKTLQTLCILAsdhhkransFNSENLPSLVVCPPTLVGHWVAEIKKYFPN 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714 109 LEPEEINVVMNKTDIGRIPG----SRVTVLGYGLLTTDAETLLDalntQNFRVVIVDESHYMKSrtaARSKILLPMVQ-K 183
Cdd:cd17999   81 AFLKPLAYVGPPQERRRLREqgekHNVIVASYDVLRNDIEVLTK----IEWNYCVLDEGHIIKN---SKTKLSKAVKQlK 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714 184 ARRAILLTGTPALGRPEELFMQIEALFPQKFGTWIEYAKRYcnahVRYFGKRRQWDC------RGASNLSELHQLLNDIM 257
Cdd:cd17999  154 ANHRLILSGTPIQNNVLELWSLFDFLMPGYLGTEKQFQRRF----LKPILASRDSKAsakeqeAGALALEALHKQVLPFL 229


                 ...
gi 568908714 258 IRR 260
Cdd:cd17999  230 LRR 232
DEXHc_RAD54A cd18067
DEXH-box helicase domain of RAD54A; DNA repair and recombination protein RAD54A, also known as ...
 41-260 4.02e-16

DEXH-box helicase domain of RAD54A; DNA repair and recombination protein RAD54A, also known as RAD54L or RAD54, plays a role in homologous recombination related repair of DNA double-strand breaks. RAD54A is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350825 [Multi-domain]  Cd Length: 243  Bit Score: 77.90  E-value: 4.02e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714  41 LLPFQKDGIVFAL-----RRDGR---CMVADEMGLGKTIQAIAIAYFYKEEWP--------LLIVVPSSLRYPWIEELEK 104
Cdd:cd18067    1 LRPHQREGVKFLYrcvtgRRIRGshgCIMADEMGLGKTLQCITLMWTLLRQSPqckpeidkAIVVSPSSLVKNWANELGK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714 105 WI-PELEPEEINVVMNKTDIGRIPGS---RVTVLGYGLLTTDAETL---LDALNTQNFRVVIVDESHYMKSRTAARSKIL 177
Cdd:cd18067   81 WLgGRLQPLAIDGGSKKEIDRKLVQWasqQGRRVSTPVLIISYETFrlhVEVLQKGEVGLVICDEGHRLKNSDNQTYQAL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714 178 LPMvqKARRAILLTGTPALGRPEELFMQIEALFPQKFGTWIEYAKRYCNAHVRyfG-------KRRQwdcRGASNLSELH 250
Cdd:cd18067  161 DSL--NTQRRVLLSGTPIQNDLSEYFSLVNFVNPGILGTAAEFKKNFELPILK--GrdadaseKERQ---LGEEKLQELI 233

                        250
                 ....*....|
gi 568908714 251 QLLNDIMIRR 260
Cdd:cd18067  234 SIVNRCIIRR 243
DEXQc_SRCAP cd18003
DEXH/Q-box helicase domain of SRCAP; Snf2-related CBP activator (SRCAP, also known as SWR1 or ...
 62-261 6.04e-16

DEXH/Q-box helicase domain of SRCAP; Snf2-related CBP activator (SRCAP, also known as SWR1 or DOMO1) is the core catalytic component of the multiprotein chromatin-remodeling SRCAP complex, that is necessary for the incorporation of the histone variant H2A.Z into nucleosomes. SRCAP is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350761 [Multi-domain]  Cd Length: 223  Bit Score: 77.01  E-value: 6.04e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714  62 ADEMGLGKTIQAIA-IAYF--YKEEW-PLLIVVPSSLRYPWIEELEKWIPEL----------EPEEINVVMNKTDigrip 127
Cdd:cd18003   25 ADEMGLGKTIQTIAlLAHLacEKGNWgPHLIVVPTSVMLNWEMEFKRWCPGFkiltyygsakERKLKRQGWMKPN----- 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714 128 GSRVTVLGYGLLTTDAEtlldALNTQNFRVVIVDESHYMKSRTAARSKILLPMvqKARRAILLTGTPALGRPEELFMQIE 207
Cdd:cd18003  100 SFHVCITSYQLVVQDHQ----VFKRKKWKYLILDEAHNIKNFKSQRWQTLLNF--NTQRRLLLTGTPLQNSLMELWSLMH 173

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 568908714 208 ALFPQKFGTWIEYakrycnahvryfgkrRQWDCRGASNLSELHQLLNDIMIRRL 261
Cdd:cd18003  174 FLMPHIFQSHQEF---------------KEWFSNPLTAMSEGSQEENEELVRRL 212
DEXHc_CHD1L cd18006
DEAH/Q-box helicase domain of CHD1L; Chromodomain helicase DNA binding protein 1 like (CHD1L, ...
 41-260 7.36e-16

DEAH/Q-box helicase domain of CHD1L; Chromodomain helicase DNA binding protein 1 like (CHD1L, also known as ALC1) is involved in DNA repair by regulating chromatin relaxation following DNA damage. CHD1L is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350764 [Multi-domain]  Cd Length: 216  Bit Score: 76.71  E-value: 7.36e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714  41 LLPFQKDGIVFALRRDGR---CMVADEMGLGKTIQAIAI----AYFYKEEWPLLIVVPSSLRYPWIEELEKWIPELepEE 113
Cdd:cd18006    1 LRPYQLEGVNWLLQCRAEqhgCILGDEMGLGKTCQTISLlwylAGRLKLLGPFLVLCPLSVLDNWKEELNRFAPDL--SV 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714 114 INVVMNKTDIGRIPGSRVTVLGYG-LLTTDAETLLDA--LNTQNFRVVIVDESHYMKSRTAARSKILLPmvQKARRAILL 190
Cdd:cd18006   79 ITYMGDKEKRLDLQQDIKSTNRFHvLLTTYEICLKDAsfLKSFPWASLVVDEAHRLKNQNSLLHKTLSE--FSVDFRLLL 156

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714 191 TGTPALGRPEELFMQIEALFPQKFGtwIEYAKRYcnahVRYFGKRRqwdcRGASNLSELHQLLNDIMIRR 260
Cdd:cd18006  157 TGTPIQNSLQELYALLSFIEPNVFP--KDKLDDF----IKAYSETD----DESETVEELHLLLQPFLLRR 216
DEXHc_CHD1 cd18053
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 1; ...
 59-260 7.88e-16

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 1; Chromodomain-helicase-DNA-binding protein 1 (CHD1) is an ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. It regulates polymerase II transcription and is also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. It is not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. CHD1 is also associated with histone deacetylase (HDAC) activity. It is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350811 [Multi-domain]  Cd Length: 237  Bit Score: 77.01  E-value: 7.88e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714  59 CMVADEMGLGKTIQAIA-IAYFYKEEW---PLLIVVPSSLRYPWIEELEKWIPELepeeiNVVMNKTDIGRIPGSR---- 130
Cdd:cd18053   42 CILADEMGLGKTIQTISfLNYLFHEHQlygPFLLVVPLSTLTSWQREIQTWAPQM-----NAVVYLGDINSRNMIRthew 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714 131 ----VTVLGYGLLTTDAETLL---DALNTQNFRVVIVDESHYMKSRTAARSKILLPMvqKARRAILLTGTPALGRPEELF 203
Cdd:cd18053  117 mhpqTKRLKFNILLTTYEILLkdkSFLGGLNWAFIGVDEAHRLKNDDSLLYKTLIDF--KSNHRLLITGTPLQNSLKELW 194

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 568908714 204 MQIEALFPQKFGTWIEYAKRYcnahvryfGKRRQwdcrgaSNLSELHQLLNDIMIRR 260
Cdd:cd18053  195 SLLHFIMPEKFSSWEDFEEEH--------GKGRE------YGYASLHKELEPFLLRR 237
DEXHc_CHD8 cd18060
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 8; ...
 41-260 5.23e-15

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 8; Chromodomain-helicase-DNA-binding protein 8 (CHD8) is a DNA helicase that acts as a chromatin remodeling factor and regulates transcription. It also acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. It suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity and of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. It also acts as a negative regulator of Wnt signaling pathway and CTNNB1-targeted gene expression. CHD8 is also involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. It also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription. CHD8 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350818 [Multi-domain]  Cd Length: 222  Bit Score: 74.32  E-value: 5.23e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714  41 LLPFQKDGI---VFALRRDGRCMVADEMGLGKTIQAIAI---AYFYKEEWPLLIVVPSSLRYPWIEELEKWIpelepeEI 114
Cdd:cd18060    1 LREYQLEGVnwlLFNWYNRQNCILADEMGLGKTIQSIAFlqeVYNVGIHGPFLVIAPLSTITNWEREFNTWT------EM 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714 115 NVVMN-----------------KTDIGR-IPGSrvtvLGYGLLTTDAETLLD---ALNTQNFRVVIVDESHYMKSRTAar 173
Cdd:cd18060   75 NTIVYhgslasrqmiqqyemycKDSRGRlIPGA----YKFDALITTFEMILSdcpELREIEWRCVIIDEAHRLKNRNC-- 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714 174 sKIL--LPMVQKARRaILLTGTPALGRPEELFMQIEALFPQKFGTWIEYakrycnahVRYFGkrrqwDCRGASNLSELHQ 251
Cdd:cd18060  149 -KLLdsLKHMDLEHK-VLLTGTPLQNTVEELFSLLHFLEPSQFPSESEF--------LKDFG-----DLKTEEQVQKLQA 213


                 ....*....
gi 568908714 252 LLNDIMIRR 260
Cdd:cd18060  214 ILKPMMLRR 222
Helicase_C pfam00271
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ...
 334-439 7.43e-15

Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.


Pssm-ID: 459740 [Multi-domain]  Cd Length: 109  Bit Score: 70.70  E-value: 7.43e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714  334 IKMLLQNDSLKFLVFAHHLSMLQaCTEAVIESKSRYIRIDGSVPSSERIHLVNQFqKDPDTRVaILSIQAAGQGLTFTAA 413
Cdd:pfam00271   7 LELLKKERGGKVLIFSQTKKTLE-AELLLEKEGIKVARLHGDLSQEEREEILEDF-RKGKIDV-LVATDVAERGLDLPDV 83

                          90       100
                  ....*....|....*....|....*.
gi 568908714  414 SHVVFAELYWDPGHIKQAEDRAHRIG 439
Cdd:pfam00271  84 DLVINYDLPWNPASYIQRIGRAGRAG 109
DEXHc_SMARCA2 cd18063
DEXH-box helicase domain of SMARCA2; SWI/SNF related, matrix associated, actin dependent ...
 60-262 2.09e-14

DEXH-box helicase domain of SMARCA2; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 (SMARCA2, also known as brahma homolog) is a component of the BAF complex. SMARCA2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350821 [Multi-domain]  Cd Length: 251  Bit Score: 73.17  E-value: 2.09e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714  60 MVADEMGLGKTIQAIAIAYFYKEE----WPLLIVVPSSLRYPWIEELEKWIPELEPEEI--NVVMNKTDIGRIPGSRVTV 133
Cdd:cd18063   46 ILADEMGLGKTIQTIALITYLMEHkrlnGPYLIIVPLSTLSNWTYEFDKWAPSVVKISYkgTPAMRRSLVPQLRSGKFNV 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714 134 lgygLLTTDAETLLDA--LNTQNFRVVIVDESHYMKSRTAARSKILLPMVQKARRaILLTGTPALGRPEELFMQIEALFP 211
Cdd:cd18063  126 ----LLTTYEYIIKDKhiLAKIRWKYMIVDEGHRMKNHHCKLTQVLNTHYVAPRR-ILLTGTPLQNKLPELWALLNFLLP 200

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 568908714 212 QKFGTWIEYaKRYCNAHVRYFGKRRQWDCRGAS-NLSELHQLLNDIMIRRLK 262
Cdd:cd18063  201 TIFKSCSTF-EQWFNAPFAMTGERVDLNEEETIlIIRRLHKVLRPFLLRRLK 251
DEXHc_ERCC6 cd18000
DEXH-box helicase domain of ERCC6; ERCC excision repair 6, chromatin remodeling factor (ERCC6, ...
 41-211 3.28e-14

DEXH-box helicase domain of ERCC6; ERCC excision repair 6, chromatin remodeling factor (ERCC6, also known Cockayne syndrome group B (CSB), Rad26 in Saccharomyces cerevisiae, and Rhp26 in Schizosaccharomyces pombe) is a DNA-binding protein that is important in transcription-coupled excision repair. ERCC6 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350758 [Multi-domain]  Cd Length: 193  Bit Score: 71.20  E-value: 3.28e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714  41 LLPFQKDGIVFALRRDGRC---MVADEMGLGKTIQAIA----IAYFYKEEWPLLIVVPSSLRYPWIEELEKWIPELEpee 113
Cdd:cd18000    1 LFKYQQTGVQWLWELHCQRvggILGDEMGLGKTIQIIAflaaLHHSKLGLGPSLIVCPATVLKQWVKEFHRWWPPFR--- 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714 114 iNVVMNKTDIGRIPGS------------RVTVLGYGLLTTDAETLL---DALNTQNFRVVIVDESHYMKSRTAARSKIL- 177
Cdd:cd18000   78 -VVVLHSSGSGTGSEEklgsierksqliRKVVGDGGILITTYEGFRkhkDLLLNHNWQYVILDEGHKIRNPDAEITLACk 156

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 568908714 178 -LPMVQKarraILLTGTPALGRPEELFMQIEALFP 211
Cdd:cd18000  157 qLRTPHR----LILSGTPIQNNLKELWSLFDFVFP 187
DEXHc_ERCC6L cd18001
DEXH-box helicase domain of ERCC6L; ERCC excision repair 6 like, spindle assembly checkpoint ...
 41-194 3.44e-14

DEXH-box helicase domain of ERCC6L; ERCC excision repair 6 like, spindle assembly checkpoint helicase (ERCC6L, also known as RAD26L) is an essential component of the mitotic spindle assembly checkpoint, by acting as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase. ERCC6L is proposed to stimulate cancer cell proliferation by promoting cell cycle through a way of RAB31-MAPK-CDK2. ERCC6L is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350759 [Multi-domain]  Cd Length: 232  Bit Score: 72.02  E-value: 3.44e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714  41 LLPFQKDGI-----VFALRRDGrcMVADEMGLGKTIQAIA-IAYFYKEEW--PLLIVVPSSLRYPWIEELEKWIPELEPE 112
Cdd:cd18001    1 LYPHQREGVawlwsLHDGGKGG--ILADDMGLGKTVQICAfLSGMFDSGLikSVLVVMPTSLIPHWVKEFAKWTPGLRVK 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714 113 E---INVVMNKTDIGRIPGSRVTVLG-YGLLTTDAETlLDALNTQNFR--VVIVDESHYMKSRTAARSKILLPMVQKARr 186
Cdd:cd18001   79 VfhgTSKKERERNLERIQRGGGVLLTtYGMVLSNTEQ-LSADDHDEFKwdYVILDEGHKIKNSKTKSAKSLREIPAKNR- 156


                 ....*...
gi 568908714 187 aILLTGTP 194
Cdd:cd18001  157 -IILTGTP 163
DEXHc_ATRX cd18068
DEXH-box helicase domain of ATRX; Transcriptional regulator ATRX (also called alpha ...
 41-226 4.76e-14

DEXH-box helicase domain of ATRX; Transcriptional regulator ATRX (also called alpha thalassemia/mental retardation syndrome X-linked and X-linked nuclear protein or XNP) is involved in transcriptional regulation and chromatin remodeling. Mutations in humans cause mental retardation, X-linked, syndromic, with hypotonic facies 1 (MRXSHF1) and alpha-thalassemia myelodysplasia syndrome (ATMDS). ATRX is part of the a DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350826 [Multi-domain]  Cd Length: 246  Bit Score: 71.84  E-value: 4.76e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714  41 LLPFQKDGIVF-----------ALRRDGR-CMVADEMGLGKTIQAIAIAY--FYKEEWP----LLIVVPSSLRYPWIEEL 102
Cdd:cd18068    1 LKPHQVDGVQFmwdccceslkkTKKSPGSgCILAHCMGLGKTLQVVTFLHtvLLCEKLEnfsrVLVVCPLNTVLNWLNEF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714 103 EKWIPELEPEEINVVMNKTDIGRIPGSR-----------VTVLGYGL---LTTD---------AETLLDALNTQNFRVVI 159
Cdd:cd18068   81 EKWQEGLKDEEKIEVNELATYKRPQERSyklqrwqeeggVMIIGYDMyriLAQErnvksreklKEIFNKALVDPGPDFVV 160

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568908714 160 VDESHYMKSRTAARSKILLPMvqKARRAILLTGTPALGRPEELFMQIEALFPQKFGTWIEYAKRYCN 226
Cdd:cd18068  161 CDEGHILKNEASAVSKAMNSI--RTKRRIVLTGTPLQNNLIEYHCMVNFVKPNLLGTIKEFRNRFVN 225
DEXHc_ARIP4 cd18069
DEXH-box helicase domain of ARIP4; Androgen receptor-interacting protein 4 (ARIP4, also called ...
 44-224 9.46e-14

DEXH-box helicase domain of ARIP4; Androgen receptor-interacting protein 4 (ARIP4, also called RAD54 like 2 or RAD54L2 ) modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. ARIP4 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350827 [Multi-domain]  Cd Length: 227  Bit Score: 70.61  E-value: 9.46e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714  44 FQKDGIVFALRR----DG-RCMVADEMGLGKTIQAIAIAYFYKEEWPL---LIVVPSSLRYPWIEELEKWIPelEPEEIN 115
Cdd:cd18069   11 FLYDNIIESLERykgsSGfGCILAHSMGLGKTLQVISFLDVLLRHTGAktvLAIVPVNTLQNWLSEFNKWLP--PPEALP 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714 116 VVMNKTdigripgSRVTVLGYGLLTTDAETLLDA----------LNTQNFR------VVIVDESHYMKSRTAARSKILLP 179
Cdd:cd18069   89 NVRPRP-------FKVFILNDEHKTTAARAKVIEdwvkdggvllMGYEMFRlrpgpdVVICDEGHRIKNCHASTSQALKN 161

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 568908714 180 MvqKARRAILLTGTPALGRPEELFMQIEALFPQKFGTWIEYAKRY 224
Cdd:cd18069  162 I--RSRRRIVLTGYPLQNNLIEYWCMVDFVRPDFLGTRQEFSNMF 204
DEXHc_SMARCA1 cd18065
DEAH-box helicase domain of SMARCA1; SWI/SNF related, matrix associated, actin dependent ...
 60-262 1.77e-13

DEAH-box helicase domain of SMARCA1; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 (SMARCA1, also called SNF2L) is a component of NURF (nucleosome-remodeling factor) and CERF (CECR2-containing-remodeling factor) complexes which promote the perturbation of chromatin structure in an ATP-dependent manner. SMARCA1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350823 [Multi-domain]  Cd Length: 233  Bit Score: 70.05  E-value: 1.77e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714  60 MVADEMGLGKTIQAIAIAYFYKE----EWPLLIVVPSSLRYPWIEELEKWIPELE------PEEINVVMNKTDIgrIPGS 129
Cdd:cd18065   38 ILADEMGLGKTLQTIALLGYLKHyrniPGPHMVLVPKSTLHNWMNEFKRWVPSLRavcligDKDARAAFIRDVM--MPGE 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714 130 -RVTVLGYGLLTTDAETlldaLNTQNFRVVIVDESHYMKSRTAARSKILLPMvqKARRAILLTGTPALGRPEELFMQIEA 208
Cdd:cd18065  116 wDVCVTSYEMVIKEKSV----FKKFNWRYLVIDEAHRIKNEKSKLSEIVREF--KTTNRLLLTGTPLQNNLHELWALLNF 189

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 568908714 209 LFPQKFGTWIEYAKrycnahvrYFGKRrqwDCRGASNLSE-LHQLLNDIMIRRLK 262
Cdd:cd18065  190 LLPDVFNSADDFDS--------WFDTK---NCLGDQKLVErLHAVLKPFLLRRIK 233
DEXHc_SMARCA4 cd18062
DEXH-box helicase domain of SMARCA4; SWI/SNF related, matrix associated, actin dependent ...
 60-262 2.42e-13

DEXH-box helicase domain of SMARCA4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 (SMARCA4, also known as transcription activator BRG1) is a component of the CREST-BRG1 complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. Mutation of SMARCA4 (BRG1), the ATPase of BAF (mSWI/SNF) and PBAF complexes, contributes to a range of malignancies and neurologic disorders. SMARCA4 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350820 [Multi-domain]  Cd Length: 251  Bit Score: 70.07  E-value: 2.42e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714  60 MVADEMGLGKTIQAIAIAYFYKE----EWPLLIVVPSSLRYPWIEELEKWIPELepeeINVVMNKTDIGR---IPGSR-- 130
Cdd:cd18062   46 ILADEMGLGKTIQTIALITYLMEhkriNGPFLIIVPLSTLSNWVYEFDKWAPSV----VKVSYKGSPAARrafVPQLRsg 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714 131 ---VTVLGYGLLTTDAETLLDAlntqNFRVVIVDESHYMKSRTAARSKILLPMVQKARRaILLTGTPALGRPEELFMQIE 207
Cdd:cd18062  122 kfnVLLTTYEYIIKDKQILAKI----RWKYMIVDEGHRMKNHHCKLTQVLNTHYVAPRR-LLLTGTPLQNKLPELWALLN 196

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 568908714 208 ALFPQKFGTWIEYaKRYCNAHVRYFGKRRQWDCRGAS-NLSELHQLLNDIMIRRLK 262
Cdd:cd18062  197 FLLPTIFKSCSTF-EQWFNAPFAMTGEKVDLNEEETIlIIRRLHKVLRPFLLRRLK 251
DEXHc_CHD5 cd18057
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 5; ...
 41-260 3.27e-13

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 5; Chromodomain-helicase-DNA-binding protein 5 (CHD5) is a chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. It is thought to specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3 and plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. As a tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa. CHD5 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350815 [Multi-domain]  Cd Length: 232  Bit Score: 69.32  E-value: 3.27e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714  41 LLPFQKDGI---VFALRRDGRCMVADEMGLGKTIQAIAIAY-FYKE---EWPLLIVVPSSLRYPWIEELEKWIPEL---- 109
Cdd:cd18057    1 LHPYQLEGLnwlRFSWAQGTDTILADEMGLGKTVQTIVFLYsLYKEghsKGPYLVSAPLSTIINWEREFEMWAPDFyvvt 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714 110 ------------EPE---EINVVMNKTDIGRIPGS-----RVTVLGYGLLTTDAETlldaLNTQNFRVVIVDESHYMKSR 169
Cdd:cd18057   81 ytgdkesrsvirENEfsfEDNAIRSGKKVFRMKKEaqikfHVLLTSYELITIDQAI----LGSIEWACLVVDEAHRLKNN 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714 170 TAARSKILLPMvqKARRAILLTGTPALGRPEELFMQIEALFPQKFGTWIEYAKRYCnahvryfgkrrqwDCRGASNLSEL 249
Cdd:cd18057  157 QSKFFRVLNSY--KIDYKLLLTGTPLQNNLEELFHLLNFLTPERFNNLEGFLEEFA-------------DISKEDQIKKL 221

                        250
                 ....*....|.
gi 568908714 250 HQLLNDIMIRR 260
Cdd:cd18057  222 HDLLGPHMLRR 232
HELICc smart00490
helicase superfamily c-terminal domain;
368-439 4.43e-13

helicase superfamily c-terminal domain;


Pssm-ID: 197757 [Multi-domain]  Cd Length: 82  Bit Score: 64.54  E-value: 4.43e-13
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568908714   368 RYIRIDGSVPSSERIHLVNQFQKDPdtRVAILSIQAAGQGLTFTAASHVVFAELYWDPGHIKQAEDRAHRIG 439
Cdd:smart00490  13 KVARLHGGLSQEEREEILDKFNNGK--IKVLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGRAGRAG 82
DEXHc_CHD6 cd18058
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 6; ...
 59-260 6.60e-13

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 6; Chromodomain-helicase-DNA-binding protein 6 (CHD6) is a DNA-dependent ATPase that plays a role in chromatin remodeling. It regulates transcription by disrupting nucleosomes in a largely non-sliding manner which strongly increases the accessibility of chromatin. It activates transcription of specific genes in response to oxidative stress through interaction with NFE2L2.2 and acts as a transcriptional repressor of different viruses including influenza virus or papillomavirus. During influenza virus infection, the viral polymerase complex localizes CHD6 to inactive chromatin where it gets degraded in a proteasome independent-manner. CHD6 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350816 [Multi-domain]  Cd Length: 222  Bit Score: 68.14  E-value: 6.60e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714  59 CMVADEMGLGKTIQAIAIAY---FYKEEWPLLIVVPSSLRYPWIEELEKWIpelepeEIN-VVMNKTDIgripgSRVTVL 134
Cdd:cd18058   22 CILADEMGLGKTIQSITFLSeifLMGIRGPFLIIAPLSTITNWEREFRTWT------EMNaIVYHGSQI-----SRQMIQ 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714 135 GY-------------------GLLTTDAETLLDA--LNTQNFRVVIVDESHYMKSRTAARSKILLPMVQKARraILLTGT 193
Cdd:cd18058   91 QYemyyrdeqgnplsgifkfqVVITTFEMILADCpeLKKINWSCVIIDEAHRLKNRNCKLLEGLKLMALEHK--VLLTGT 168

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568908714 194 PALGRPEELFMQIEALFPQKFGTWIEYAKRycnahvryFGkrrqwDCRGASNLSELHQLLNDIMIRR 260
Cdd:cd18058  169 PLQNSVEELFSLLNFLEPSQFPSETTFLEE--------FG-----DLKTEEQVKKLQSILKPMMLRR 222
DEXHc_HLTF1_SMARC3 cd18071
DEXH-box helicase domain of HLTF1; Helicase like transcription factor (HLTF1, also known as ...
 60-204 2.00e-12

DEXH-box helicase domain of HLTF1; Helicase like transcription factor (HLTF1, also known as HIP116 or SMARCA3) has both helicase and E3 ubiquitin ligase activities and ATP-dependent nucleosome-remodeling activity. HLTF1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350829 [Multi-domain]  Cd Length: 239  Bit Score: 67.11  E-value: 2.00e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714  60 MVADEMGLGKTIQAIAIAYFYkeewPLLIVVPSSLRYPWIEELEKWIpelEPEEINVVM----NKT-DIGRIPGSRVTVL 134
Cdd:cd18071   52 ILADDMGLGKTLTTISLILAN----FTLIVCPLSVLSNWETQFEEHV---KPGQLKVYTyhggERNrDPKLLSKYDIVLT 124

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568908714 135 GYGLLTTDAETLLDA-LNTQNFRVVIVDESHYMKSRTAARSKILLPMvqKARRAILLTGTPALGRPEELFM 204
Cdd:cd18071  125 TYNTLASDFGAKGDSpLHTINWLRVVLDEGHQIRNPNAQQTKAVLNL--SSERRWVLTGTPIQNSPKDLGS 193
DEXHc_CHD7 cd18059
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 7; ...
 41-260 2.59e-12

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 7; Chromodomain-helicase-DNA-binding protein 7 (CHD7) is a probable transcription regulator. It may be involved in the 45S precursor rRNA production. CHD7 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350817 [Multi-domain]  Cd Length: 222  Bit Score: 66.21  E-value: 2.59e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714  41 LLPFQKDGI---VFALRRDGRCMVADEMGLGKTIQAIAIAY-FYKE--EWPLLIVVPSSLRYPWIEELEKWIpelepeEI 114
Cdd:cd18059    1 LREYQLEGVnwlLFNWYNTRNCILADEMGLGKTIQSITFLYeIYLKgiHGPFLVIAPLSTIPNWEREFRTWT------EL 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714 115 NVVMNKTDIG------------RIPGSRVTVLGY---GLLTTDAETLLDALNTQN--FRVVIVDESHYMKSRTAARSKIL 177
Cdd:cd18059   75 NVVVYHGSQAsrrtiqlyemyfKDPQGRVIKGSYkfhAIITTFEMILTDCPELRNipWRCVVIDEAHRLKNRNCKLLEGL 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714 178 LPMvqKARRAILLTGTPALGRPEELFMQIEALFPQKFGTWIEYAKRycnahvryFGkrrqwDCRGASNLSELHQLLNDIM 257
Cdd:cd18059  155 KMM--DLEHKVLLTGTPLQNTVEELFSLLHFLEPSRFPSETTFMQE--------FG-----DLKTEEQVQKLQAILKPMM 219


                 ...
gi 568908714 258 IRR 260
Cdd:cd18059  220 LRR 222
DEXHc_CHD4 cd18056
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 4; ...
 41-260 3.40e-12

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 4; Chromodomain-helicase-DNA-binding protein 4 (CHD4) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. CHD4 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350814 [Multi-domain]  Cd Length: 232  Bit Score: 66.24  E-value: 3.40e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714  41 LLPFQKDGI---VFALRRDGRCMVADEMGLGKTIQAIAIAY-FYKE---EWPLLIVVPSSLRYPWIEELEKWIPEL---- 109
Cdd:cd18056    1 LHPYQLEGLnwlRFSWAQGTDTILADEMGLGKTVQTAVFLYsLYKEghsKGPFLVSAPLSTIINWEREFEMWAPDMyvvt 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714 110 ------------EPE---EINVVMNKTDIGRIPGS-----RVTVLGYGLLTTDaetlLDALNTQNFRVVIVDESHYMKSR 169
Cdd:cd18056   81 yvgdkdsraiirENEfsfEDNAIRGGKKASRMKKEasvkfHVLLTSYELITID----MAILGSIDWACLIVDEAHRLKNN 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714 170 TAARSKILLPMvqKARRAILLTGTPALGRPEELFMQIEALFPQKFGTWIEYAKRYCnahvryfgkrrqwDCRGASNLSEL 249
Cdd:cd18056  157 QSKFFRVLNGY--SLQHKLLLTGTPLQNNLEELFHLLNFLTPERFHNLEGFLEEFA-------------DIAKEDQIKKL 221

                        250
                 ....*....|.
gi 568908714 250 HQLLNDIMIRR 260
Cdd:cd18056  222 HDMLGPHMLRR 232
DEXQc_bact_SNF2 cd18013
DEXQ-box helicase domain of bacterial SNF2 family proteins; Proteins belonging to the SNF2 ...
 43-226 7.71e-12

DEXQ-box helicase domain of bacterial SNF2 family proteins; Proteins belonging to the SNF2 family of DNA dependent ATPases are important members of the chromatin remodeling complexes that are implicated in epigenetic control of gene expression. The Snf2 family comprise a large group of ATP-hydrolyzing proteins that are ubiquitous in eukaryotes, but also present in eubacteria and archaea. The bacterial SNF2 present in this family are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350771 [Multi-domain]  Cd Length: 218  Bit Score: 64.68  E-value: 7.71e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714  43 PFQKDGIVFALRRDGRCMVADeMGLGKT---IQAIAIAYFYKEEWPLLIVVPSSL-RYPWIEELEKWipELEPEEINVVM 118
Cdd:cd18013    3 PYQKVAINFIIEHPYCGLFLD-MGLGKTvttLTALSDLQLDDFTRRVLVIAPLRVaRSTWPDEVEKW--NHLRNLTVSVA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714 119 NKTDIGRIP----GSRVTVLGYGLLttdaETLLDALNTQ-NFRVVIVDESHYMKSRTAARSKILLPMVQKARRAILLTGT 193
Cdd:cd18013   80 VGTERQRSKaantPADLYVINRENL----KWLVNKSGDPwPFDMVVIDELSSFKSPRSKRFKALRKVRPVIKRLIGLTGT 155

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 568908714 194 PALGRPEELFMQIEAL-FPQKFGTWIE-YAKRYCN 226
Cdd:cd18013  156 PSPNGLMDLWAQIALLdQGERLGRSITaYRERWFD 190
DpdE NF041062
protein DpdE;
58-200 1.41e-11

protein DpdE;


Pssm-ID: 468989 [Multi-domain]  Cd Length: 1048  Bit Score: 67.30  E-value: 1.41e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714   58 RCMVADEMGLGKTIQAIAIAYFYKEEWP---LLIVVPSSLRYPWIEELEkwipelepeeinvvmNKTDIGRIPGSRVTVL 134
Cdd:NF041062  172 RYLLADEVGLGKTIEAGLVIRQHLLDNPdarVLVLVPDALVRQWRRELR---------------DKFFLDDFPGARVRVL 236

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568908714  135 GYglltTDAETLLDalNTQNFRVVIVDESHYM-------KSRTAARSKILLPMVQKARRAILLTGTPALGRPE 200
Cdd:NF041062  237 SH----EEPERWEP--LLDAPDLLVVDEAHQLarlawsgDPPERARYRELAALAHAAPRLLLLSATPVLGNEE 303
DEXHc_CHD3 cd18055
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 3; ...
 60-260 5.52e-11

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 3; Chromodomain-helicase-DNA-binding protein 3 (CHD3) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. It is required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity. CHD3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350813 [Multi-domain]  Cd Length: 232  Bit Score: 62.72  E-value: 5.52e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714  60 MVADEMGLGKTIQAIAIAY-FYKE---EWPLLIVVPSSLRYPWIEELEKWIPEL----------------EPE---EINV 116
Cdd:cd18055   23 ILADEMGLGKTIQTIVFLYsLYKEghtKGPFLVSAPLSTIINWEREFQMWAPDFyvvtytgdkdsraiirENEfsfDDNA 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714 117 VMNKTDIGRIPGS-----RVTVLGYGLLTTDAetllDALNTQNFRVVIVDESHYMKSRTAARSKILLPMvqKARRAILLT 191
Cdd:cd18055  103 VKGGKKAFKMKREaqvkfHVLLTSYELVTIDQ----AALGSIRWACLVVDEAHRLKNNQSKFFRVLNGY--KIDHKLLLT 176

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568908714 192 GTPALGRPEELFMQIEALFPQKFGTWIEYAKRYCnahvryfgkrrqwDCRGASNLSELHQLLNDIMIRR 260
Cdd:cd18055  177 GTPLQNNLEELFHLLNFLTPERFNNLEGFLEEFA-------------DISKEDQIKKLHDLLGPHMLRR 232
DEXHc_CHD9 cd18061
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 9; ...
 59-260 8.43e-11

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 9; Chromodomain-helicase-DNA-binding protein 9 (CHD9) acts as a transcriptional coactivator for PPARA and possibly other nuclear receptors. It is proposed to be a ATP-dependent chromatin remodeling protein. CHD9 has DNA-dependent ATPase activity and binds to A/T-rich DNA. It also associates with A/T-rich regulatory regions in promoters of genes that participate in the differentiation of progenitors during osteogenesis. CHD9 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350819 [Multi-domain]  Cd Length: 222  Bit Score: 61.95  E-value: 8.43e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714  59 CMVADEMGLGKTIQAIAIAY-FYKE--EWPLLIVVPSSLRYPWIEELEKWIpelepeEINVVMNKTDI------------ 123
Cdd:cd18061   22 CILADEMGLGKTIQSITFLYeILLTgiRGPFLIIAPLSTIANWEREFRTWT------DLNVVVYHGSLisrqmiqqyemy 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714 124 GRIPGSRVTVLGYGL--LTTDAETLLDA---LNTQNFRVVIVDESHYMKSRTAARSKILLPMvqKARRAILLTGTPALGR 198
Cdd:cd18061   96 FRDSQGRIIRGAYRFqaIITTFEMILGGcpeLNAIDWRCVIIDEAHRLKNKNCKLLEGLKLM--NLEHKVLLTGTPLQNT 173

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568908714 199 PEELFMQIEALFPQKFGTWieyakrycNAHVRYFGkrrqwDCRGASNLSELHQLLNDIMIRR 260
Cdd:cd18061  174 VEELFSLLHFLEPLRFPSE--------STFMQEFG-----DLKTEEQVQKLQAILKPMMLRR 222
SSL2 COG1061
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
40-210 1.73e-10

Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];


Pssm-ID: 440681 [Multi-domain]  Cd Length: 566  Bit Score: 63.51  E-value: 1.73e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714  40 KLLPFQKDGI--VFALRRDG--RCMVADEMGLGKTIQAIAIAYFYKEEWPLLIVVPS-SLRYPWIEELEKWIPelepeEI 114
Cdd:COG1061   80 ELRPYQQEALeaLLAALERGggRGLVVAPTGTGKTVLALALAAELLRGKRVLVLVPRrELLEQWAEELRRFLG-----DP 154

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714 115 NVVMNKTDIGRipgsRVTVLGYGLLTTDAEtlLDALNtQNFRVVIVDESHymksRTAARS-KILLPMVQKARRaILLTGT 193
Cdd:COG1061  155 LAGGGKKDSDA----PITVATYQSLARRAH--LDELG-DRFGLVIIDEAH----HAGAPSyRRILEAFPAAYR-LGLTAT 222

                        170
                 ....*....|....*....
gi 568908714 194 PAL--GRPEELFMQIEALF 210
Cdd:COG1061  223 PFRsdGREILLFLFDGIVY 241
DEXHc_RE cd17926
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family ...
 41-194 6.16e-08

DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family is composed of helicase restriction enzymes and similar proteins such as TFIIH basal transcription factor complex helicase XPB subunit. These proteins are part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350684 [Multi-domain]  Cd Length: 146  Bit Score: 51.92  E-value: 6.16e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714  41 LLPFQKDGI--VFALRRDGRCMVADEMGLGKTIQAIA-IAYFYKEewPLLIVVPS-SLRYPWIEELEKWIPELEPEEINV 116
Cdd:cd17926    1 LRPYQEEALeaWLAHKNNRRGILVLPTGSGKTLTALAlIAYLKEL--RTLIVVPTdALLDQWKERFEDFLGDSSIGLIGG 78

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568908714 117 VMNKTDIGRIpgsrVTVLGYGLLTTDAETLLDALNtqNFRVVIVDESHYMKSRTAARskiLLPMVQKARRaILLTGTP 194
Cdd:cd17926   79 GKKKDFDDAN----VVVATYQSLSNLAEEEKDLFD--QFGLLIVDEAHHLPAKTFSE---ILKELNAKYR-LGLTATP 146
ResIII pfam04851
Type III restriction enzyme, res subunit;
66-194 1.07e-05

Type III restriction enzyme, res subunit;


Pssm-ID: 398492 [Multi-domain]  Cd Length: 162  Bit Score: 45.74  E-value: 1.07e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714   66 GLGKTIQAIAIAYFYKEEWPL---LIVVPS-SLRYPWIEELEKWIPELEPEEINVVMNKTDIGRiPGSRVTVLGYGLLTT 141
Cdd:pfam04851  33 GSGKTLTAAKLIARLFKKGPIkkvLFLVPRkDLLEQALEEFKKFLPNYVEIGEIISGDKKDESV-DDNKIVVTTIQSLYK 111

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 568908714  142 DAETLLDALNTQNFRVVIVDESHymksRTAARS-KILLPMVQKARRaILLTGTP 194
Cdd:pfam04851 112 ALELASLELLPDFFDVIIIDEAH----RSGASSyRNILEYFKPAFL-LGLTATP 160
DEXQc_SHPRH cd18070
DEXQ-box helicase domain of SHPRH; E3 ubiquitin-protein ligase SHPRH is a ubiquitously ...
 41-107 1.16e-04

DEXQ-box helicase domain of SHPRH; E3 ubiquitin-protein ligase SHPRH is a ubiquitously expressed protein that contains motifs characteristic of several DNA repair proteins, transcription factors, and helicases. SHPRH is a functional homolog of S. cerevisiae RAD5 and is involved in DNA repair. SHPRH is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350828 [Multi-domain]  Cd Length: 257  Bit Score: 43.87  E-value: 1.16e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714  41 LLPFQKDGIVFALRRDGrcMVADEMGLGKTIQAIAI-------------AYFYKEEWPL----------------LIVVP 91
Cdd:cd18070    1 LLPYQRRAVNWMLVPGG--ILADEMGLGKTVEVLALillhprpdndldaADDDSDEMVCcpdclvaetpvsskatLIVCP 78

                         90
                 ....*....|....*.
gi 568908714  92 SSLRYPWIEELEKWIP 107
Cdd:cd18070   79 SAILAQWLDEINRHVP 94
SF2-N cd00046
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ...
 61-193 2.92e-04

N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.


Pssm-ID: 350668 [Multi-domain]  Cd Length: 146  Bit Score: 41.23  E-value: 2.92e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714  61 VADEMGLGKTIQA--IAIAYFYKEEWPLLIVVP-SSLRYPWIEELEKWIPELEPEEINVVMN--KTDIG-RIPGSRVTVL 134
Cdd:cd00046    6 ITAPTGSGKTLAAllAALLLLLKKGKKVLVLVPtKALALQTAERLRELFGPGIRVAVLVGGSsaEEREKnKLGDADIIIA 85

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568908714 135 GYGLLTTDAETLlDALNTQNFRVVIVDESHYMKSRTAARSKILLPMVQKAR---RAILLTGT 193
Cdd:cd00046   86 TPDMLLNLLLRE-DRLFLKDLKLIIVDEAHALLIDSRGALILDLAVRKAGLknaQVILLSAT 146
DEXHc_viral_Ns3 cd17931
DEXH-box helicase domain of NS3 protease-helicase; NS3 is a nonstructural multifunctional ...
 66-195 3.17e-04

DEXH-box helicase domain of NS3 protease-helicase; NS3 is a nonstructural multifunctional protein found in pestiviruses that contains an N-terminal protease and a C-terminal helicase. The N-terminal domain is a chymotrypsin-like serine protease, which is responsible for most of the maturation cleavages of the polyprotein precursor in the cytosolic side of the endoplasmic reticulum membrane. The C-terminal domain, about two-thirds of NS3, is a helicase belonging to superfamily 2 (SF2) thought to be important for unwinding highly structured regions of the RNA genome during replication. NS3 plays an essential role in viral polyprotein processing and genome replication. NS3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350689 [Multi-domain]  Cd Length: 151  Bit Score: 41.38  E-value: 3.17e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714  66 GLGKTIQAIA--IAYFYKEEWPLLIVVPSSLRypwIEELEKWIPELEPEEINVVMNKTDIGRIPgsrVTVLGYGLLTtda 143
Cdd:cd17931   11 GAGKTTRVLPqiIREAIKKRLRTLVLAPTRVV---AAEMYEALRGLPIRYRTGAVKEEHGGNEI---VDYMCHGTFT--- 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 568908714 144 ETLLDALNTQNFRVVIVDESHYMKSRT-AARSKILLPMVQKARRAILLTGTPA 195
Cdd:cd17931   82 CRLLSPKRVPNYNLIIMDEAHFTDPASiAARGYIHTRVEMGEAAVIFMTATPP 134
PRK01297 PRK01297
ATP-dependent RNA helicase RhlB; Provisional
 323-440 2.20e-03

ATP-dependent RNA helicase RhlB; Provisional


Pssm-ID: 234938 [Multi-domain]  Cd Length: 475  Bit Score: 40.67  E-value: 2.20e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908714 323 AIAKAGAVKDYIKMLLQNDSLKFLVFAHHLSMLQACTEAVIESKSRYIRIDGSVPSSERIHLVNQFqKDPDTRVAIlSIQ 402
Cdd:PRK01297 316 AVAGSDKYKLLYNLVTQNPWERVMVFANRKDEVRRIEERLVKDGINAAQLSGDVPQHKRIKTLEGF-REGKIRVLV-ATD 393

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 568908714 403 AAGQGLTFTAASHVVFAELYWDPghikqaEDRAHRIGQ 440
Cdd:PRK01297 394 VAGRGIHIDGISHVINFTLPEDP------DDYVHRIGR 425
SF2_C cd18785
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ...
 397-450 5.10e-03

C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350172 [Multi-domain]  Cd Length: 77  Bit Score: 36.14  E-value: 5.10e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 568908714 397 AILSIQAAGQGLTFTAASHVVFAELYWDPGHIKQAEDRAHRIGQCSSVnIHYLI 450
Cdd:cd18785   25 ILVATNVLGEGIDVPSLDTVIFFDPPSSAASYIQRVGRAGRGGKDEGE-VILFV 77
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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