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Conserved domains on  [gi|568937583|ref|XP_006530574|]
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trichoplein keratin filament-binding protein isoform X2 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TPH super family cl38442
Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of ...
 1-279 8.03e-17

Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of eukaryotic proteins. Trichoplein or mitostatin, was first defined as a meiosis-specific nuclear structural protein. It has since been linked with mitochondrial movement. It is associated with the mitochondrial outer membrane, and over-expression leads to reduction in mitochondrial motility whereas lack of it enhances mitochondrial movement. The activity appears to be mediated through binding the mitochondria to the actin intermediate filaments (IFs). The family is in the trichohyalin-plectin-homology domain.


The actual alignment was detected with superfamily member pfam13868:

Pssm-ID: 464007 [Multi-domain]  Cd Length: 341  Bit Score: 79.19  E-value: 8.03e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568937583    1 MRVEEERRQLEGRLQAEALRQQMEELKQKEMEATKLKKEQENLLRQRWELERLEEERRQMAALRRKTELGRFLKHQYNAQ 80
Cdd:pfam13868  60 EEEKEEERKEERKRYRQELEEQIEEREQKRQEEYEEKLQEREQMDEIVERIQEEDQAEAEEKLEKQRQLREEIDEFNEEQ 139

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568937583   81 LNRRTQEIQEELEVDGRILQALLEKEGELQQVELARREQARADAAWMKQVIEEQLQLEKAREAE---LQQLLREEAKEMW 157
Cdd:pfam13868 140 AEWKELEKEEEREEDERILEYLKEKAEREEEREAEREEIEEEKEREIARLRAQQEKAQDEKAERdelRAKLYQEEQERKE 219

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568937583  158 EKREAEWAREQVARDRLMSEvltGRQQQILEKIEQNRRAQEETLKHREKLIRSLEEGKQLAQRAKEESEELKLARKQELE 237
Cdd:pfam13868 220 RQKEREEAEKKARQRQELQQ---AREEQIELKERRLAEEAEREEEEFERMLRKQAEDEEIEQEEAEKRRMKRLEHRRELE 296

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 568937583  238 AQVAERQGQEWEAARQEEEEEEEARQAEEHSNALLQQEAKTM 279
Cdd:pfam13868 297 KQIEEREEQRAAEREEELEEGERLREEEAERRERIEEERQKK 338
 
Name Accession Description Interval E-value
TPH pfam13868
Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of ...
 1-279 8.03e-17

Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of eukaryotic proteins. Trichoplein or mitostatin, was first defined as a meiosis-specific nuclear structural protein. It has since been linked with mitochondrial movement. It is associated with the mitochondrial outer membrane, and over-expression leads to reduction in mitochondrial motility whereas lack of it enhances mitochondrial movement. The activity appears to be mediated through binding the mitochondria to the actin intermediate filaments (IFs). The family is in the trichohyalin-plectin-homology domain.


Pssm-ID: 464007 [Multi-domain]  Cd Length: 341  Bit Score: 79.19  E-value: 8.03e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568937583    1 MRVEEERRQLEGRLQAEALRQQMEELKQKEMEATKLKKEQENLLRQRWELERLEEERRQMAALRRKTELGRFLKHQYNAQ 80
Cdd:pfam13868  60 EEEKEEERKEERKRYRQELEEQIEEREQKRQEEYEEKLQEREQMDEIVERIQEEDQAEAEEKLEKQRQLREEIDEFNEEQ 139

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568937583   81 LNRRTQEIQEELEVDGRILQALLEKEGELQQVELARREQARADAAWMKQVIEEQLQLEKAREAE---LQQLLREEAKEMW 157
Cdd:pfam13868 140 AEWKELEKEEEREEDERILEYLKEKAEREEEREAEREEIEEEKEREIARLRAQQEKAQDEKAERdelRAKLYQEEQERKE 219

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568937583  158 EKREAEWAREQVARDRLMSEvltGRQQQILEKIEQNRRAQEETLKHREKLIRSLEEGKQLAQRAKEESEELKLARKQELE 237
Cdd:pfam13868 220 RQKEREEAEKKARQRQELQQ---AREEQIELKERRLAEEAEREEEEFERMLRKQAEDEEIEQEEAEKRRMKRLEHRRELE 296

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 568937583  238 AQVAERQGQEWEAARQEEEEEEEARQAEEHSNALLQQEAKTM 279
Cdd:pfam13868 297 KQIEEREEQRAAEREEELEEGERLREEEAERRERIEEERQKK 338
PTZ00121 PTZ00121
MAEBL; Provisional
 2-287 5.72e-10

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 60.15  E-value: 5.72e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568937583    2 RVEEERRQLEGRLQAEALRQQMEELKQKEMEATKLKKEQENLLRQRWELERLEEERRQMAALRRKTELGRFLKHQYNAQL 81
Cdd:PTZ00121 1471 KADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKAAEAKKKADEAKKAEEAKKADEAKKAEEAKKADEAKKAEEKKKADE 1550

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568937583   82 NRRTQEIQ--------EELEVDGRILQALLEKEGELQQVELARREQARADAAWMKQVIEEQLQLEKAREAELQQLLREE- 152
Cdd:PTZ00121 1551 LKKAEELKkaeekkkaEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEe 1630

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568937583  153 ---------AKEMWEKREAEWAREQVARDRLMSEVLTGRQQQILEKIEQNRRAQEETLKHREKLIRSLEEGKQLAQRAKE 223
Cdd:PTZ00121 1631 ekkkveqlkKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKK 1710

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568937583  224 ESEELKLARKQELEAQVAERQGQEWEAARQEEEEEEEARQAEEHSNALLQQEAKTMAEKGYQPK 287
Cdd:PTZ00121 1711 EAEEKKKAEELKKAEEENKIKAEEAKKEAEEDKKKAEEAKKDEEEKKKIAHLKKEEEKKAEEIR 1774
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 2-294 2.94e-08

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 54.94  E-value: 2.94e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568937583   2 RVEEERRQLEGRLQAEALRQQmeeLKQKEMEATKLKKEQENLLRQRwELERLEEERRQMAALRRKTELGRFLKHQYNAQL 81
Cdd:COG1196  243 ELEAELEELEAELEELEAELA---ELEAELEELRLELEELELELEE-AQAEEYELLAELARLEQDIARLEERRRELEERL 318

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568937583  82 NRRTQEIQEELEVDGRILQALLEKEGELQQVELARREQARAdaawMKQVIEEQLQLEKAREAELQQLLREEAKEMWEKRE 161
Cdd:COG1196  319 EELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAE----LAEAEEALLEAEAELAEAEEELEELAEELLEALRA 394

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568937583 162 AEWAREQVARDRLMSEVLTGRQQQILEKIEQNRRAQEETLKHREKLIRSLEEGKQLAQRAKEESEELKLARKQEL-EAQV 240
Cdd:COG1196  395 AAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLeEAAL 474

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 568937583 241 AERQGQEWEAARQEEEEEEEARQAEEHSNALLQQEAKTMAEKGYQPKLHGHLRI 294
Cdd:COG1196  475 LEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLLAGLRGLAGAVAV 528
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 17-242 1.92e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 39.65  E-value: 1.92e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568937583    17 EALRQQMEELKQKEMEATKLKKEQENLLRQRWELERLEEERRQMAALRRKTELGRFLKHQYNAQLNRRTQEIQEELEVDG 96
Cdd:TIGR02168  684 EKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEI 763

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568937583    97 RILQALLEKEGELQQVELARREQARADAawmkQVIEEQLQLEKAREAELQQLLREEAKEMWEKRE-AEWAREQVARDRLM 175
Cdd:TIGR02168  764 EELEERLEEAEEELAEAEAEIEELEAQI----EQLKEELKALREALDELRAELTLLNEEAANLRErLESLERRIAATERR 839

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568937583   176 SEVLTGRQQQILEKIEQNRRAQEETLKHREKLIRSLEEGKQLAQRAKEESEELKLaRKQELEAQVAE 242
Cdd:TIGR02168  840 LEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNERASLEEALALLRS-ELEELSEELRE 905
 
Name Accession Description Interval E-value
TPH pfam13868
Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of ...
 1-279 8.03e-17

Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of eukaryotic proteins. Trichoplein or mitostatin, was first defined as a meiosis-specific nuclear structural protein. It has since been linked with mitochondrial movement. It is associated with the mitochondrial outer membrane, and over-expression leads to reduction in mitochondrial motility whereas lack of it enhances mitochondrial movement. The activity appears to be mediated through binding the mitochondria to the actin intermediate filaments (IFs). The family is in the trichohyalin-plectin-homology domain.


Pssm-ID: 464007 [Multi-domain]  Cd Length: 341  Bit Score: 79.19  E-value: 8.03e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568937583    1 MRVEEERRQLEGRLQAEALRQQMEELKQKEMEATKLKKEQENLLRQRWELERLEEERRQMAALRRKTELGRFLKHQYNAQ 80
Cdd:pfam13868  60 EEEKEEERKEERKRYRQELEEQIEEREQKRQEEYEEKLQEREQMDEIVERIQEEDQAEAEEKLEKQRQLREEIDEFNEEQ 139

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568937583   81 LNRRTQEIQEELEVDGRILQALLEKEGELQQVELARREQARADAAWMKQVIEEQLQLEKAREAE---LQQLLREEAKEMW 157
Cdd:pfam13868 140 AEWKELEKEEEREEDERILEYLKEKAEREEEREAEREEIEEEKEREIARLRAQQEKAQDEKAERdelRAKLYQEEQERKE 219

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568937583  158 EKREAEWAREQVARDRLMSEvltGRQQQILEKIEQNRRAQEETLKHREKLIRSLEEGKQLAQRAKEESEELKLARKQELE 237
Cdd:pfam13868 220 RQKEREEAEKKARQRQELQQ---AREEQIELKERRLAEEAEREEEEFERMLRKQAEDEEIEQEEAEKRRMKRLEHRRELE 296

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 568937583  238 AQVAERQGQEWEAARQEEEEEEEARQAEEHSNALLQQEAKTM 279
Cdd:pfam13868 297 KQIEEREEQRAAEREEELEEGERLREEEAERRERIEEERQKK 338
PTZ00121 PTZ00121
MAEBL; Provisional
 2-287 5.72e-10

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 60.15  E-value: 5.72e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568937583    2 RVEEERRQLEGRLQAEALRQQMEELKQKEMEATKLKKEQENLLRQRWELERLEEERRQMAALRRKTELGRFLKHQYNAQL 81
Cdd:PTZ00121 1471 KADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKAAEAKKKADEAKKAEEAKKADEAKKAEEAKKADEAKKAEEKKKADE 1550

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568937583   82 NRRTQEIQ--------EELEVDGRILQALLEKEGELQQVELARREQARADAAWMKQVIEEQLQLEKAREAELQQLLREE- 152
Cdd:PTZ00121 1551 LKKAEELKkaeekkkaEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEe 1630

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568937583  153 ---------AKEMWEKREAEWAREQVARDRLMSEVLTGRQQQILEKIEQNRRAQEETLKHREKLIRSLEEGKQLAQRAKE 223
Cdd:PTZ00121 1631 ekkkveqlkKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKK 1710

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568937583  224 ESEELKLARKQELEAQVAERQGQEWEAARQEEEEEEEARQAEEHSNALLQQEAKTMAEKGYQPK 287
Cdd:PTZ00121 1711 EAEEKKKAEELKKAEEENKIKAEEAKKEAEEDKKKAEEAKKDEEEKKKIAHLKKEEEKKAEEIR 1774
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 2-294 2.94e-08

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 54.94  E-value: 2.94e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568937583   2 RVEEERRQLEGRLQAEALRQQmeeLKQKEMEATKLKKEQENLLRQRwELERLEEERRQMAALRRKTELGRFLKHQYNAQL 81
Cdd:COG1196  243 ELEAELEELEAELEELEAELA---ELEAELEELRLELEELELELEE-AQAEEYELLAELARLEQDIARLEERRRELEERL 318

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568937583  82 NRRTQEIQEELEVDGRILQALLEKEGELQQVELARREQARAdaawMKQVIEEQLQLEKAREAELQQLLREEAKEMWEKRE 161
Cdd:COG1196  319 EELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAE----LAEAEEALLEAEAELAEAEEELEELAEELLEALRA 394

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568937583 162 AEWAREQVARDRLMSEVLTGRQQQILEKIEQNRRAQEETLKHREKLIRSLEEGKQLAQRAKEESEELKLARKQEL-EAQV 240
Cdd:COG1196  395 AAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLeEAAL 474

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 568937583 241 AERQGQEWEAARQEEEEEEEARQAEEHSNALLQQEAKTMAEKGYQPKLHGHLRI 294
Cdd:COG1196  475 LEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLLAGLRGLAGAVAV 528
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 5-295 1.29e-07

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 52.63  E-value: 1.29e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568937583   5 EERRQLEGRLQAEALRQQMEELKQKEMEATKLKKEQENLLRQ-RWELERLEEERRQMAALRRKTELGRFLKHQYNAQLNR 83
Cdd:COG1196  220 EELKELEAELLLLKLRELEAELEELEAELEELEAELEELEAElAELEAELEELRLELEELELELEEAQAEEYELLAELAR 299

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568937583  84 RTQEIQEELEVDGRILQALLEKEGELQQVELARREQARADAAWMKQVIE---EQLQLEKAREAELQQLLREEAKEmwEKR 160
Cdd:COG1196  300 LEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEaeeELEEAEAELAEAEEALLEAEAEL--AEA 377

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568937583 161 EAEWAREQVARDRLMSE--VLTGRQQQILEKIEQNRRAQEETLKHREKLIRSLEEGKQLAQRAKEESEELKLARKQELEA 238
Cdd:COG1196  378 EEELEELAEELLEALRAaaELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEE 457

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 568937583 239 QVAERQGQEWEAARQEEEEEEEARQAEEHSNALLQQEAKTMAEKGYQPKLHGHLRIA 295
Cdd:COG1196  458 EEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAAL 514
PTZ00121 PTZ00121
MAEBL; Provisional
 1-235 1.27e-06

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 49.75  E-value: 1.27e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568937583    1 MRVEEERRQLEGRLQAEALRQQMEelkQKEMEATKLKKEQENLLRQRWELERLEEERRQMAALRRKTELGRFLKHQYNAQ 80
Cdd:PTZ00121 1539 AKKAEEKKKADELKKAEELKKAEE---KKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKA 1615

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568937583   81 LNRR--TQEIQEELEVDGRILQALLEKEGELQQVELARREQARAD---AAWMKQVIEEQLQLEKAREAELQQLLREEA-- 153
Cdd:PTZ00121 1616 EEAKikAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKikaAEEAKKAEEDKKKAEEAKKAEEDEKKAAEAlk 1695

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568937583  154 KEMWEKREAEWAREQVARDRLMSEVLTGRQQQILEKIEQNRRAQEETLKHREKLIRSLEEGKQLAQRAKEESEELKLARK 233
Cdd:PTZ00121 1696 KEAEEAKKAEELKKKEAEEKKKAEELKKAEEENKIKAEEAKKEAEEDKKKAEEAKKDEEEKKKIAHLKKEEEKKAEEIRK 1775


                  ..
gi 568937583  234 QE 235
Cdd:PTZ00121 1776 EK 1777
PTZ00121 PTZ00121
MAEBL; Provisional
 1-229 1.76e-06

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 49.37  E-value: 1.76e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568937583    1 MRVEEERRQLEGRLQAEALRQQMEELKQKEMEATKLKKEQENLLRQrwelerleeERRQMAALRRKTELGRFLKHQYNAQ 80
Cdd:PTZ00121 1527 AKKAEEAKKADEAKKAEEKKKADELKKAEELKKAEEKKKAEEAKKA---------EEDKNMALRKAEEAKKAEEARIEEV 1597

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568937583   81 LNRRTQEIQEELEvdgrilQALLEKEGELQQVELARREQARADAAWMKQVIEEQL----QLEKAREAELQQLLREEAKEM 156
Cdd:PTZ00121 1598 MKLYEEEKKMKAE------EAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKkkaeELKKAEEENKIKAAEEAKKAE 1671

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568937583  157 WEKREAEWAREQVARDRLMSEVLTgRQQQILEKIEQNRRAQEETLKHREKLIRSLEEGKQLAQRAKEESEELK 229
Cdd:PTZ00121 1672 EDKKKAEEAKKAEEDEKKAAEALK-KEAEEAKKAEELKKKEAEEKKKAEELKKAEEENKIKAEEAKKEAEEDK 1743
PTZ00121 PTZ00121
MAEBL; Provisional
 2-287 3.03e-06

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 48.60  E-value: 3.03e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568937583    2 RVEEERRQLEGRLQAEALRQQMEELKQKEMEATKLKKEQENLLR---QRWELERLEEERRQMAALRRKTELGRFLKHQYN 78
Cdd:PTZ00121 1498 KADEAKKAAEAKKKADEAKKAEEAKKADEAKKAEEAKKADEAKKaeeKKKADELKKAEELKKAEEKKKAEEAKKAEEDKN 1577

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568937583   79 AQLnRRTQEIQEELEVDGRILQALLEKEGELQQVELARREQARADAAWMKQVIEEQLQLEKAREAELQQLLREE----AK 154
Cdd:PTZ00121 1578 MAL-RKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEelkkAE 1656

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568937583  155 EMWEKREAEWAREQvARDRLMSEVLTGRQQQILEKIEQNRRAQEETLKHREKLIRSLEEGKQLAQRAKEESEELKLARKQ 234
Cdd:PTZ00121 1657 EENKIKAAEEAKKA-EEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKKKAEELKKAEEENKIKAEEA 1735

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 568937583  235 ELEAQVAERQGQEWEAARQEEEEEEEARQAEEHSNALLQQEAKTMAEKGYQPK 287
Cdd:PTZ00121 1736 KKEAEEDKKKAEEAKKDEEEKKKIAHLKKEEEKKAEEIRKEKEAVIEEELDEE 1788
PTZ00121 PTZ00121
MAEBL; Provisional
 2-282 7.41e-05

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 44.36  E-value: 7.41e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568937583    2 RVEEERRQLEGRLQAEALRQQMEELKQKEMEATKLKKEQENllrQRWELERLEEERRQMAALRRKTELGRFLKHQYNAQL 81
Cdd:PTZ00121 1110 KAEEARKAEEAKKKAEDARKAEEARKAEDARKAEEARKAED---AKRVEIARKAEDARKAEEARKAEDAKKAEAARKAEE 1186

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568937583   82 NRRTQEIQEELEVDGRILQALLEKEGELQQV---ELARREQARADAAWMKQVIEEQLQLEKAREAELQQLLREEAKEMWE 158
Cdd:PTZ00121 1187 VRKAEELRKAEDARKAEAARKAEEERKAEEArkaEDAKKAEAVKKAEEAKKDAEEAKKAEEERNNEEIRKFEEARMAHFA 1266

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568937583  159 KREAEWAREQVARDRLMSEVLTGRQQQILEKIEQNRRAQEETLKHREKliRSLEEGKQLAQRAKEESEEL-KLARKQELE 237
Cdd:PTZ00121 1267 RRQAAIKAEEARKADELKKAEEKKKADEAKKAEEKKKADEAKKKAEEA--KKADEAKKKAEEAKKKADAAkKKAEEAKKA 1344

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 568937583  238 AQVAERQGQEWEAARQEEEEEEEARQAEEHSNALLQQEAKTMAEK 282
Cdd:PTZ00121 1345 AEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEE 1389
PTZ00121 PTZ00121
MAEBL; Provisional
 2-261 4.62e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 41.67  E-value: 4.62e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568937583    2 RVEEERRQLEGRLQAEALR----QQMEELKQKEMEATKLKKEQENLLRQRWELERLEEERRQMAALRrktelgrflkhqy 77
Cdd:PTZ00121 1207 KAEEERKAEEARKAEDAKKaeavKKAEEAKKDAEEAKKAEEERNNEEIRKFEEARMAHFARRQAAIK------------- 1273

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568937583   78 nAQLNRRTQEIQEELEVdgrilqallEKEGELQQVELARR-EQARADAAWMKQVIEEQLQLEKAREAelQQLLREEAKEM 156
Cdd:PTZ00121 1274 -AEEARKADELKKAEEK---------KKADEAKKAEEKKKaDEAKKKAEEAKKADEAKKKAEEAKKK--ADAAKKKAEEA 1341

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568937583  157 WEKREAEWAREQVARDRLMSevlTGRQQQILEKIEQNRRAQEETLKHREKLIRSLEEGKQLAQRAKEESEELKLARKQEL 236
Cdd:PTZ00121 1342 KKAAEAAKAEAEAAADEAEA---AEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKKKADELKKAAAAKK 1418

                         250       260
                  ....*....|....*....|....*
gi 568937583  237 EAQVAERQGQEWEAARQEEEEEEEA 261
Cdd:PTZ00121 1419 KADEAKKKAEEKKKADEAKKKAEEA 1443
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 17-242 1.92e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 39.65  E-value: 1.92e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568937583    17 EALRQQMEELKQKEMEATKLKKEQENLLRQRWELERLEEERRQMAALRRKTELGRFLKHQYNAQLNRRTQEIQEELEVDG 96
Cdd:TIGR02168  684 EKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEI 763

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568937583    97 RILQALLEKEGELQQVELARREQARADAawmkQVIEEQLQLEKAREAELQQLLREEAKEMWEKRE-AEWAREQVARDRLM 175
Cdd:TIGR02168  764 EELEERLEEAEEELAEAEAEIEELEAQI----EQLKEELKALREALDELRAELTLLNEEAANLRErLESLERRIAATERR 839

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568937583   176 SEVLTGRQQQILEKIEQNRRAQEETLKHREKLIRSLEEGKQLAQRAKEESEELKLaRKQELEAQVAE 242
Cdd:TIGR02168  840 LEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNERASLEEALALLRS-ELEELSEELRE 905
PTZ00121 PTZ00121
MAEBL; Provisional
 1-215 2.65e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 39.35  E-value: 2.65e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568937583    1 MRVEEERRQLEGRLQAEALRQQMEELKQKEMEAtklKKEQENLLRQRWELERLEEERRQMAALRRKTElgrflkhqynaQ 80
Cdd:PTZ00121 1607 MKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLK---KKEAEEKKKAEELKKAEEENKIKAAEEAKKAE-----------E 1672

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568937583   81 LNRRTQEIQEELEVDGRILQALLEKEGELQQVELARREQARAdaawmKQVIEEQLQLEKAREAELQQLLREEAKEmweKR 160
Cdd:PTZ00121 1673 DKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEE-----KKKAEELKKAEEENKIKAEEAKKEAEED---KK 1744

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 568937583  161 EAEWAREQVARDRLMSEVLTGRQQQILEKIEQNRRAQEETLKHREKLIRSLEEGK 215
Cdd:PTZ00121 1745 KAEEAKKDEEEKKKIAHLKKEEEKKAEEIRKEKEAVIEEELDEEDEKRRMEVDKK 1799
PTZ00121 PTZ00121
MAEBL; Provisional
 2-261 3.79e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 38.97  E-value: 3.79e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568937583    2 RVEEERRQLEGRLQAEALRQQMEELKQKEMEATKLKKEQENLLRQRWELERLEEERRQMAALRRKTELGRFLKHQYNAQL 81
Cdd:PTZ00121 1310 KAEEAKKADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEE 1389

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568937583   82 NRRTQEIQEELEVDGRILQALLEKEGELQQVElarreQARADAAWMKQVIEEQLQLEKAREAElqqllrEEAKEMWEKRE 161
Cdd:PTZ00121 1390 KKKADEAKKKAEEDKKKADELKKAAAAKKKAD-----EAKKKAEEKKKADEAKKKAEEAKKAD------EAKKKAEEAKK 1458

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568937583  162 AEWAREQVARDRLMSEVLTGRQQQilEKIEQNRRAQEETLKHREKLIRSLEEGKQLAQ-RAKEESEELKLARKQELEAQV 240
Cdd:PTZ00121 1459 AEEAKKKAEEAKKADEAKKKAEEA--KKADEAKKKAEEAKKKADEAKKAAEAKKKADEaKKAEEAKKADEAKKAEEAKKA 1536

                         250       260
                  ....*....|....*....|.
gi 568937583  241 AERQGQEWEAARQEEEEEEEA 261
Cdd:PTZ00121 1537 DEAKKAEEKKKADELKKAEEL 1557
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 2-244 4.33e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 38.76  E-value: 4.33e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568937583   2 RVEEERRQLEGRLQAEALRQQMEELKQKEMEATKLKKEQENLLRQRWELERLEEERRQMAALRRKTELGRFLKHQYNAQL 81
Cdd:COG1196  367 LLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEE 446

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568937583  82 NRRTQEIQEELEVDGRILQALLEKEGELQQVELARREQARADAAWMKQVIEEQLQLEKAREAELQQLLREEAKEMWEKRE 161
Cdd:COG1196  447 AAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLLAGLRGLAGAV 526

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568937583 162 AEWAREQVARDRLMSEVLTGRQQQILEKIEQNRRAQEETLKHREKLIRSLEEGKQLAQRAKEESEELKLARKQELEAQVA 241
Cdd:COG1196  527 AVLIGVEAAYEAALEAALAAALQNIVVEDDEVAAAAIEYLKAAKAGRATFLPLDKIRARAALAAALARGAIGAAVDLVAS 606


                 ...
gi 568937583 242 ERQ 244
Cdd:COG1196  607 DLR 609
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 2-274 5.36e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 38.50  E-value: 5.36e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568937583     2 RVEEERRQLEGRLQAEALRQQMEELKQKEMEATKLKKEQENLLRQ-RWELERLEEERRQMAALRRKTELGRFLKHQYNAQ 80
Cdd:TIGR02168  217 ELKAELRELELALLVLRLEELREELEELQEELKEAEEELEELTAElQELEEKLEELRLEVSELEEEIEELQKELYALANE 296

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568937583    81 LNRRTQEIQEELEVDGRILQALLEKEGELQQVElARREQARADAAWMKQVIEEQLQLEKAREAELqqllrEEAKEMWEKR 160
Cdd:TIGR02168  297 ISRLEQQKQILRERLANLERQLEELEAQLEELE-SKLDELAEELAELEEKLEELKEELESLEAEL-----EELEAELEEL 370

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568937583   161 EAEWAREQVARDRLMSEV--LTGRQQQILEKIEQNRRAQEETLKHREKLIRSLEEGKQLAQRAKEESEELKLARKQELEA 238
Cdd:TIGR02168  371 ESRLEELEEQLETLRSKVaqLELQIASLNNEIERLEARLERLEDRRERLQQEIEELLKKLEEAELKELQAELEELEEELE 450

                          250       260       270
                   ....*....|....*....|....*....|....*.
gi 568937583   239 QVAERQGQEWEAARQEEEEEEEARQAEEHSNALLQQ 274
Cdd:TIGR02168  451 ELQEELERLEEALEELREELEEAEQALDAAERELAQ 486
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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