NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|568956891|ref|XP_006531108|]
View 

carbohydrate sulfotransferase 4 isoform X1 [Mus musculus]

Protein Classification

sulfotransferase family protein( domain architecture ID 229543)

sulfotransferase family protein may utilize 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to its substrate(s)

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
Sulfotransfer_1 super family cl21551
Sulfotransferase domain;
181-357 1.12e-10

Sulfotransferase domain;


The actual alignment was detected with superfamily member pfam00685:

Pssm-ID: 473908 [Multi-domain]  Cd Length: 253  Bit Score: 61.59  E-value: 1.12e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568956891  181 LSLQALYPLLTDPslNLHVVHLVRDPRAVFRSREHTTieLMVDSHivlgqhletiKEEDQPYYAMKIICKSQV---DIVK 257
Cdd:pfam00685  79 LPLHLLPKSLWDP--NAKIIYLVRNPKDVAVSYYHFF--RMAKLL----------KAPGTPFEFVEDFLNGKVncgSYFD 144
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568956891  258 AIQT-LPEALQQRYLFLRYEDLVRAPLAQTTRLYKFVGLDFLP-----HLQTWVYNVTRGKGMGQHAFHTNARNALN--- 328
Cdd:pfam00685 145 HVKGwWKLRPPGNILFLRYEDLKKDPRGEIKKIAEFLGIPLTEeeldkIVKHLSFENMKGNPCLNYSKLPKEVSPFFrkg 224
                         170       180
                  ....*....|....*....|....*....
gi 568956891  329 VSQAWRWSLPYEKVSQLQDACGEAMDLLG 357
Cdd:pfam00685 225 LVGDWKNYFTPEQAEKFDEIYQEKMKGTG 253
Sulfotransfer_3 super family cl46325
Sulfotransferase family;
44-297 1.76e-07

Sulfotransferase family;


The actual alignment was detected with superfamily member pfam13469:

Pssm-ID: 480665  Cd Length: 173  Bit Score: 50.75  E-value: 1.76e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568956891   44 VLVLSSWRSGSSFVGQLFGQHPDVFYLMEpawhvwmtftsstawklhmavrdLLRSVFLCDmsvfdaymnpgPRKQSSLF 123
Cdd:pfam13469   1 IFIVGLPRSGTTLLHRLLAAHPDVRPPEE-----------------------TWFVIPRIL-----------ALLQAWGK 46
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568956891  124 QWEQSRALCS--APVCDFFPAHeisspkhckllcgqqpfdmvekacrshgfvvLKEVRFLSlqALYPlltdpslNLHVVH 201
Cdd:pfam13469  47 SLEALARVPSyaRWLCDKSPSH-------------------------------LFHLDLLL--KAFP-------DAKFIH 86
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568956891  202 LVRDP-RAVFRSREHTTIELMVDSHIVLGQHLEtikeedqpyYAMKIICKSQVDIVKAIQTLPEAlqqRYLFLRYEDLVR 280
Cdd:pfam13469  87 LHRDPvDTVISSYCSLFGFTLSSYSTAFLRDIG---------LALARWSRAYERLMAARARVPPG---RFLDVRYEDLVA 154
                         250
                  ....*....|....*..
gi 568956891  281 APLAQTTRLYKFVGLDF 297
Cdd:pfam13469 155 DPEGTLRRILEFLGLPW 171
 
Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
181-357 1.12e-10

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 61.59  E-value: 1.12e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568956891  181 LSLQALYPLLTDPslNLHVVHLVRDPRAVFRSREHTTieLMVDSHivlgqhletiKEEDQPYYAMKIICKSQV---DIVK 257
Cdd:pfam00685  79 LPLHLLPKSLWDP--NAKIIYLVRNPKDVAVSYYHFF--RMAKLL----------KAPGTPFEFVEDFLNGKVncgSYFD 144
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568956891  258 AIQT-LPEALQQRYLFLRYEDLVRAPLAQTTRLYKFVGLDFLP-----HLQTWVYNVTRGKGMGQHAFHTNARNALN--- 328
Cdd:pfam00685 145 HVKGwWKLRPPGNILFLRYEDLKKDPRGEIKKIAEFLGIPLTEeeldkIVKHLSFENMKGNPCLNYSKLPKEVSPFFrkg 224
                         170       180
                  ....*....|....*....|....*....
gi 568956891  329 VSQAWRWSLPYEKVSQLQDACGEAMDLLG 357
Cdd:pfam00685 225 LVGDWKNYFTPEQAEKFDEIYQEKMKGTG 253
Sulfotransfer_3 pfam13469
Sulfotransferase family;
44-297 1.76e-07

Sulfotransferase family;


Pssm-ID: 463887  Cd Length: 173  Bit Score: 50.75  E-value: 1.76e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568956891   44 VLVLSSWRSGSSFVGQLFGQHPDVFYLMEpawhvwmtftsstawklhmavrdLLRSVFLCDmsvfdaymnpgPRKQSSLF 123
Cdd:pfam13469   1 IFIVGLPRSGTTLLHRLLAAHPDVRPPEE-----------------------TWFVIPRIL-----------ALLQAWGK 46
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568956891  124 QWEQSRALCS--APVCDFFPAHeisspkhckllcgqqpfdmvekacrshgfvvLKEVRFLSlqALYPlltdpslNLHVVH 201
Cdd:pfam13469  47 SLEALARVPSyaRWLCDKSPSH-------------------------------LFHLDLLL--KAFP-------DAKFIH 86
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568956891  202 LVRDP-RAVFRSREHTTIELMVDSHIVLGQHLEtikeedqpyYAMKIICKSQVDIVKAIQTLPEAlqqRYLFLRYEDLVR 280
Cdd:pfam13469  87 LHRDPvDTVISSYCSLFGFTLSSYSTAFLRDIG---------LALARWSRAYERLMAARARVPPG---RFLDVRYEDLVA 154
                         250
                  ....*....|....*..
gi 568956891  281 APLAQTTRLYKFVGLDF 297
Cdd:pfam13469 155 DPEGTLRRILEFLGLPW 171
 
Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
181-357 1.12e-10

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 61.59  E-value: 1.12e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568956891  181 LSLQALYPLLTDPslNLHVVHLVRDPRAVFRSREHTTieLMVDSHivlgqhletiKEEDQPYYAMKIICKSQV---DIVK 257
Cdd:pfam00685  79 LPLHLLPKSLWDP--NAKIIYLVRNPKDVAVSYYHFF--RMAKLL----------KAPGTPFEFVEDFLNGKVncgSYFD 144
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568956891  258 AIQT-LPEALQQRYLFLRYEDLVRAPLAQTTRLYKFVGLDFLP-----HLQTWVYNVTRGKGMGQHAFHTNARNALN--- 328
Cdd:pfam00685 145 HVKGwWKLRPPGNILFLRYEDLKKDPRGEIKKIAEFLGIPLTEeeldkIVKHLSFENMKGNPCLNYSKLPKEVSPFFrkg 224
                         170       180
                  ....*....|....*....|....*....
gi 568956891  329 VSQAWRWSLPYEKVSQLQDACGEAMDLLG 357
Cdd:pfam00685 225 LVGDWKNYFTPEQAEKFDEIYQEKMKGTG 253
Sulfotransfer_3 pfam13469
Sulfotransferase family;
44-297 1.76e-07

Sulfotransferase family;


Pssm-ID: 463887  Cd Length: 173  Bit Score: 50.75  E-value: 1.76e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568956891   44 VLVLSSWRSGSSFVGQLFGQHPDVFYLMEpawhvwmtftsstawklhmavrdLLRSVFLCDmsvfdaymnpgPRKQSSLF 123
Cdd:pfam13469   1 IFIVGLPRSGTTLLHRLLAAHPDVRPPEE-----------------------TWFVIPRIL-----------ALLQAWGK 46
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568956891  124 QWEQSRALCS--APVCDFFPAHeisspkhckllcgqqpfdmvekacrshgfvvLKEVRFLSlqALYPlltdpslNLHVVH 201
Cdd:pfam13469  47 SLEALARVPSyaRWLCDKSPSH-------------------------------LFHLDLLL--KAFP-------DAKFIH 86
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568956891  202 LVRDP-RAVFRSREHTTIELMVDSHIVLGQHLEtikeedqpyYAMKIICKSQVDIVKAIQTLPEAlqqRYLFLRYEDLVR 280
Cdd:pfam13469  87 LHRDPvDTVISSYCSLFGFTLSSYSTAFLRDIG---------LALARWSRAYERLMAARARVPPG---RFLDVRYEDLVA 154
                         250
                  ....*....|....*..
gi 568956891  281 APLAQTTRLYKFVGLDF 297
Cdd:pfam13469 155 DPEGTLRRILEFLGLPW 171
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH