NCBI Conserved Domain Search

Conserved domains on [gi|568973129|ref|XP_006532997|]

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sphingosine-1-phosphate transporter SPNS2 isoform X1 [Mus musculus]

Protein Classification

spinster family MFS transporter( domain architecture ID 13023647)

spinster family major facilitator superfamily (MFS) transporter may function as a sphingolipid transporter that plays a central role in endosome and/or lysosome storage

CATH: 1.20.1250.20

Gene Ontology: GO:0022857|GO:0055085|GO:0006869

PubMed: 26758938|26098515

SCOP: 3000310

TCDB: 2.A.1.49

Graphical summary

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List of domain hits

Name

Accession

Description

Interval

E-value

MFS_spinster_like

cd17328

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...

106-520

0e+00

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 561.47 E-value: 0e+00

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 106 AILSLGNVLNYLDRYTVAGVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSS 185
Cdd:cd17328    2 AVLFLINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLS 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 186 SFIPqqYFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGDWHWALRV 265
Cdd:cd17328   82 SFAP--NFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATGGWRWAFRV 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 266 SPVLGMITGTLILILVPATKRGHADQLGGQLKARTSWLRDMKALIRNRSYVFSSLATSAVSFATGALGMWIPLYLHRAQV 345
Cdd:cd17328  160 TGVLGVLLAILLLLFVREPPRGAAEGGVMAKSTATSFLADLKALAKNPSFILSTLGFTAVSFVTGALAFWAPTFFLRAFG 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 346 VqktaetcnSPPCGAKDSLIFGAITCFTGFLGVVTGAGATRWCRLRTQRADPLVCAVGMLGSAIFICLIFVAAKTSIVGA 425
Cdd:cd17328  240 V--------GDLSSADVGLIFGAITCIAGVLGVLLGGILADRLRRKTPRADPLVCAVGLLAAAPFLFLALVLALSNLLLA 311

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 426 YICIFVGETLLFSNWAITADILMYVVIPTRRATAVALQSFTSHLLGDAGSPYLIGFISDLIRQStKDSPLWEFLSLGYAL 505
Cdd:cd17328  312 WVLLFLGEFLLSLNWAPVFAILLYVVIPTRRSTASAIQILLSHLLGDAGSPYLIGLISDLLRQN-KDSPLAEAASLQYAL 390

                        410
                 ....*....|....*
gi 568973129 506 MLCPFVVVLGGMFFL 520
Cdd:cd17328  391 LLCSFVLVLGGFFFL 405

Name

Accession

Description

Interval

E-value

MFS_spinster_like

cd17328

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...

106-520

0e+00

Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 561.47 E-value: 0e+00

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 106 AILSLGNVLNYLDRYTVAGVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSS 185
Cdd:cd17328    2 AVLFLINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLS 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 186 SFIPqqYFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGDWHWALRV 265
Cdd:cd17328   82 SFAP--NFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATGGWRWAFRV 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 266 SPVLGMITGTLILILVPATKRGHADQLGGQLKARTSWLRDMKALIRNRSYVFSSLATSAVSFATGALGMWIPLYLHRAQV 345
Cdd:cd17328  160 TGVLGVLLAILLLLFVREPPRGAAEGGVMAKSTATSFLADLKALAKNPSFILSTLGFTAVSFVTGALAFWAPTFFLRAFG 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 346 VqktaetcnSPPCGAKDSLIFGAITCFTGFLGVVTGAGATRWCRLRTQRADPLVCAVGMLGSAIFICLIFVAAKTSIVGA 425
Cdd:cd17328  240 V--------GDLSSADVGLIFGAITCIAGVLGVLLGGILADRLRRKTPRADPLVCAVGLLAAAPFLFLALVLALSNLLLA 311

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 426 YICIFVGETLLFSNWAITADILMYVVIPTRRATAVALQSFTSHLLGDAGSPYLIGFISDLIRQStKDSPLWEFLSLGYAL 505
Cdd:cd17328  312 WVLLFLGEFLLSLNWAPVFAILLYVVIPTRRSTASAIQILLSHLLGDAGSPYLIGLISDLLRQN-KDSPLAEAASLQYAL 390

                        410
                 ....*....|....*
gi 568973129 506 MLCPFVVVLGGMFFL 520
Cdd:cd17328  391 LLCSFVLVLGGFFFL 405

UhpC

COG2271

Sugar phosphate permease [Carbohydrate transport and metabolism];

95-520

1.61e-38

Sugar phosphate permease [Carbohydrate transport and metabolism];

Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 146.94 E-value: 1.61e-38

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129  95 ASLGRGRGAAAAILSLGNVLNYLDRYTVAGVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCG 174
Cdd:COG2271    2 RAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 175 IFFWSAVTFSSSFIPqqYFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQ 254
Cdd:COG2271   82 LLLWGLATLLFGFAT--SFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 255 AAGdWHWALRVSPVLGMITGTLILILVpatkrghadqlggqlkartswlrdmkalirnrsyvfsSLATSAVSFATGALGM 334
Cdd:COG2271  160 AFG-WRAAFLILGLPGLLLALLRFWLL-------------------------------------ALAYFLVYFALYGFLT 201

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 335 WIPLYLHRAQVVqktaetcnsppcGAKDSLIFGAITCFTGFLGVVTGAgatrWCRLRTQRADPLVCAVGMLGSAIFICLI 414
Cdd:COG2271  202 WLPTYLVEVRGL------------SLAQAGLLLSLPFLAGIVGSLLGG----WLSDRLGRRRKLVLAIGLLLAALALLLL 265

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 415 FVAakTSIVGAYICIFVGETLLFSNWAITADILMYVVIPTRRATAVALQSfTSHLLGDAGSPYLIGFISDLirqstkdsp 494
Cdd:COG2271  266 ALL--PSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVN-TFGFLGGALGPLLVGYLLDA--------- 333

                        410       420
                 ....*....|....*....|....*.
gi 568973129 495 lwefLSLGYALMLCPFVVVLGGMFFL 520
Cdd:COG2271  334 ----TGYQAAFLLLAALALLAALLAL 355

MFS_1

pfam07690

Major Facilitator Superfamily;

108-469

1.65e-29

Major Facilitator Superfamily;

Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 120.22 E-value: 1.65e-29

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129  108 LSLGNVLNYLDRYTVAGVL-LDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSS 186
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALpLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129  187 FIPQqyFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGdWHWALRVS 266
Cdd:pfam07690  81 FASS--LWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFG-WRAAFLIL 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129  267 PVLGMITGTLILILVPATKRGHADQLGGQLKARTSWLRDmkalIRNRSYVFSSLATSAVSFATGALGMWIPLYLHRAQVV 346
Cdd:pfam07690 158 AILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKA----LLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLS 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129  347 QKTAetcnsppcgakdSLIFGAITCFTGFLGVVTGAGATRWCRLRTQRadpLVCAVGMLGSAIFICLIFVAAKTSIVGAY 426
Cdd:pfam07690 234 ALLA------------GLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLL---LALLLLILAALGLLLLSLTLSSLWLLLAL 298

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|...
gi 568973129  427 ICIFVGETLLFSNWAItadILMYVVIPTRRATAVALQSFTSHL 469
Cdd:pfam07690 299 LLLGFGFGLVFPALNA---LVSDLAPKEERGTASGLYNTAGSL 338

2A0114

TIGR00893

D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ...

110-514

7.66e-20

D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]

Pssm-ID: 273326 [Multi-domain] Cd Length: 399 Bit Score: 92.40 E-value: 7.66e-20

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129  110 LGNVLNYLDRYTVAGVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIp 189
Cdd:TIGR00893   1 LVTVINYLDRANLSFAAPMLQEDLGLSAAQYGYVFSAFSWGYVVGQFPGGWLLDRFGARKTLAVFIVIWGVFTGLQAFA- 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129  190 qQYFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGY-ITGSSVkqAAGDWHWALRVSPV 268
Cdd:TIGR00893  80 -GAYVSLYILRVLLGAAEAPFFPGIILIVASWFPASERATAVSIFNSAQGLGGIIGGpLVGWIL--IHFSWQWAFIIEGV 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129  269 LGMITGTLILILVP----------------ATKRGHADQLGGQlkARTSWLRDMKALIRNRSYVFSSLATSAVSFATGAL 332
Cdd:TIGR00893 157 LGIIWGVLWLKFIPdppqkakwlteeekyiVVGGLLAEQQGKG--PSTPKKYQIKELLKDRRVWGLALGQFLVNIGLGFF 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129  333 GMWIPLYLHRAQVVQktaetcnsppcgAKDSLIFGAITCFTGFLGVVTGAGATRWCRLRTQR---ADPLVCAVGMLGS-A 408
Cdd:TIGR00893 235 LTWFPTYLVQERGLS------------ILEAGFMASLPGIVGFIGMILGGRLSDLLLRRGKSlvfARKTAIIAGLVLSlL 302

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129  409 IFICLIFVAAKTSIVGAYICIFvGETLLFSNWAITADILmyvvipTRRATAVALQSFtsHLLGDAGS---PYLIGFIsdl 485
Cdd:TIGR00893 303 MFATNYVNIPYAALALVALGFF-GLGAGAIGWALISDNA------PGNIAGLTGGLI--NSLGNLGGivgPIVIGAI--- 370

                         410       420
                  ....*....|....*....|....*....
gi 568973129  486 irQSTKDSPLWEFLSLGYALMLCPFVVVL 514
Cdd:TIGR00893 371 --AATTGSFAGALMVVAALALIGALSYLL 397

PRK11102

Bcr/CflA family multidrug efflux MFS transporter;

126-328

1.00e-04

Bcr/CflA family multidrug efflux MFS transporter;

Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 45.29 E-value: 1.00e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 126 LLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIP--QQYFWLlvlsRGLV 203
Cdd:PRK11102  14 LPVIAADFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQtiDQLIYM----RFLH 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 204 GIGEASYSTIAPTIIGDLFTKNTRTLMLS----VFYFAiPLgsgLGYITGSSVKQAAGdWHWALRVSPVLGMITGTLILI 279
Cdd:PRK11102  90 GLAAAAASVVINALMRDMFPKEEFSRMMSfvtlVMTIA-PL---LAPIIGGWLLVWFS-WHAIFWVLALAAILAAALVFF 164

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 568973129 280 LVPATkrgHADQLGGQLKARTSwLRDMKALIRNRSyVFSSLATSAVSFA 328
Cdd:PRK11102 165 FIPET---LPKERRQPFHLRTT-IRNFASLFRHKR-VLGYMLASGFSFA 208

Name

Accession

Description

Interval

E-value

MFS_spinster_like

cd17328

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...

106-520

0e+00

Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 561.47 E-value: 0e+00

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 106 AILSLGNVLNYLDRYTVAGVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSS 185
Cdd:cd17328    2 AVLFLINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLS 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 186 SFIPqqYFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGDWHWALRV 265
Cdd:cd17328   82 SFAP--NFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATGGWRWAFRV 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 266 SPVLGMITGTLILILVPATKRGHADQLGGQLKARTSWLRDMKALIRNRSYVFSSLATSAVSFATGALGMWIPLYLHRAQV 345
Cdd:cd17328  160 TGVLGVLLAILLLLFVREPPRGAAEGGVMAKSTATSFLADLKALAKNPSFILSTLGFTAVSFVTGALAFWAPTFFLRAFG 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 346 VqktaetcnSPPCGAKDSLIFGAITCFTGFLGVVTGAGATRWCRLRTQRADPLVCAVGMLGSAIFICLIFVAAKTSIVGA 425
Cdd:cd17328  240 V--------GDLSSADVGLIFGAITCIAGVLGVLLGGILADRLRRKTPRADPLVCAVGLLAAAPFLFLALVLALSNLLLA 311

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 426 YICIFVGETLLFSNWAITADILMYVVIPTRRATAVALQSFTSHLLGDAGSPYLIGFISDLIRQStKDSPLWEFLSLGYAL 505
Cdd:cd17328  312 WVLLFLGEFLLSLNWAPVFAILLYVVIPTRRSTASAIQILLSHLLGDAGSPYLIGLISDLLRQN-KDSPLAEAASLQYAL 390

                        410
                 ....*....|....*
gi 568973129 506 MLCPFVVVLGGMFFL 520
Cdd:cd17328  391 LLCSFVLVLGGFFFL 405

UhpC

COG2271

Sugar phosphate permease [Carbohydrate transport and metabolism];

95-520

1.61e-38

Sugar phosphate permease [Carbohydrate transport and metabolism];

Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 146.94 E-value: 1.61e-38

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129  95 ASLGRGRGAAAAILSLGNVLNYLDRYTVAGVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCG 174
Cdd:COG2271    2 RAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 175 IFFWSAVTFSSSFIPqqYFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQ 254
Cdd:COG2271   82 LLLWGLATLLFGFAT--SFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 255 AAGdWHWALRVSPVLGMITGTLILILVpatkrghadqlggqlkartswlrdmkalirnrsyvfsSLATSAVSFATGALGM 334
Cdd:COG2271  160 AFG-WRAAFLILGLPGLLLALLRFWLL-------------------------------------ALAYFLVYFALYGFLT 201

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 335 WIPLYLHRAQVVqktaetcnsppcGAKDSLIFGAITCFTGFLGVVTGAgatrWCRLRTQRADPLVCAVGMLGSAIFICLI 414
Cdd:COG2271  202 WLPTYLVEVRGL------------SLAQAGLLLSLPFLAGIVGSLLGG----WLSDRLGRRRKLVLAIGLLLAALALLLL 265

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 415 FVAakTSIVGAYICIFVGETLLFSNWAITADILMYVVIPTRRATAVALQSfTSHLLGDAGSPYLIGFISDLirqstkdsp 494
Cdd:COG2271  266 ALL--PSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVN-TFGFLGGALGPLLVGYLLDA--------- 333

                        410       420
                 ....*....|....*....|....*.
gi 568973129 495 lwefLSLGYALMLCPFVVVLGGMFFL 520
Cdd:COG2271  334 ----TGYQAAFLLLAALALLAALLAL 355

MFS

cd06174

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...

108-520

1.67e-34

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.

Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 135.63 E-value: 1.67e-34

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 108 LSLGNVLNYLDRYTVAGVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSF 187
Cdd:cd06174    1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 188 IPQqyFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAG-DWHWALRVS 266
Cdd:cd06174   81 APS--FWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGfGWRAVFLIA 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 267 PVLGMITGTLILILVPATKrgHADQLGGQLKARTSWLRDMKALIRNRSYVFSSLATSAVSFATGALGMWIPLYLHRAQVv 346
Cdd:cd06174  159 AALALLAAILLLLVVPDPP--ESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGG- 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 347 qktaetcnsppCGAKDSLIFGAITCFTGFLGVVTGAGATRWCRLRTQradplVCAVGMLGSAIFICLIFVAA-KTSIVGA 425
Cdd:cd06174  236 -----------LSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKP-----LLLIGLLLMALGLALLLLAPsLLLLLLL 299

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 426 YICIFVGETLLfsnWAITADILMYVVIPTRRATAVALQSFTSHlLGDAGSPYLIGFISDlirqstkdsplwEFLSLGYAL 505
Cdd:cd06174  300 LLLLGFGLGGL---LPLSFALIAELFPPEIRGTAFGLLNTFGF-LGGAIGPLLAGFLLA------------ATFGLTGAF 363

                        410
                 ....*....|....*
gi 568973129 506 MLCPFVVVLGGMFFL 520
Cdd:cd06174  364 LVLAVLLLLAAILLL 378

AraJ

COG2814

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];

95-473

3.09e-32

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];

Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 128.17 E-value: 3.09e-32

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129  95 ASLGRGRGAAAAILSLGNVLNYLDRYTVAGVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCG 174
Cdd:COG2814    2 PATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 175 IFFWSAVTFSSSFIPQqyFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQ 254
Cdd:COG2814   82 LLLFALGSLLCALAPS--LWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLAD 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 255 AAGdWHWALRVSPVLGMITGTLILILVPATKRghadqlggqlKARTSWLRDMKALIRNRSYVFSSLATSAVSFATGALGM 334
Cdd:COG2814  160 LFG-WRWVFLVNAVLALLALLLLLRLLPESRP----------AARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFT 228

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 335 WIPLYLHraqvvqktaETCNSPPCGAkdSLIFGAITCFTGFLGVVTGAGATRWCRLRtqradplVCAVGMLGSAIFICLI 414
Cdd:COG2814  229 YLPLYLQ---------EVLGLSASAA--GLLLALFGLGGVLGALLAGRLADRFGRRR-------LLLIGLLLLALGLLLL 290

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 568973129 415 FVAakTSIVGAYICIFVGETLLFSNWAITADILMYVVIPTRRATAVALQSFTSHLLGDA 473
Cdd:COG2814  291 ALA--GSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPL 347

MFS_1

pfam07690

Major Facilitator Superfamily;

108-469

1.65e-29

Major Facilitator Superfamily;

Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 120.22 E-value: 1.65e-29

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129  108 LSLGNVLNYLDRYTVAGVL-LDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSS 186
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALpLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129  187 FIPQqyFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGdWHWALRVS 266
Cdd:pfam07690  81 FASS--LWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFG-WRAAFLIL 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129  267 PVLGMITGTLILILVPATKRGHADQLGGQLKARTSWLRDmkalIRNRSYVFSSLATSAVSFATGALGMWIPLYLHRAQVV 346
Cdd:pfam07690 158 AILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKA----LLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLS 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129  347 QKTAetcnsppcgakdSLIFGAITCFTGFLGVVTGAGATRWCRLRTQRadpLVCAVGMLGSAIFICLIFVAAKTSIVGAY 426
Cdd:pfam07690 234 ALLA------------GLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLL---LALLLLILAALGLLLLSLTLSSLWLLLAL 298

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|...
gi 568973129  427 ICIFVGETLLFSNWAItadILMYVVIPTRRATAVALQSFTSHL 469
Cdd:pfam07690 299 LLLGFGFGLVFPALNA---LVSDLAPKEERGTASGLYNTAGSL 338

MFS_MdtG_SLC18_like

cd17325

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...

131-515

1.08e-28

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 118.45 E-value: 1.08e-28

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 131 QHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIPQqyFWLLVLSRGLVGIGEASY 210
Cdd:cd17325   24 ESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATS--YWQLLLARFLQGLASAAV 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 211 STIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGdWHWALRVSPVLGMITGTLILILVPATKRGHAD 290
Cdd:cd17325  102 WPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALG-YRAPFLVCAALALLALVLALLLLPEPRPPPNK 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 291 QLGGQLKARTSwlrdMKALIRNRSYVFSSLATSAVSFATGALGMWIPLYLhrAQVVQKTAETCnsppcgakdSLIFGAIT 370
Cdd:cd17325  181 RAVSAARLRSG----LRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYA--AELGGLSPAQI---------GLLFGAQG 245

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 371 CFTGFLGVVTGAGATRWCRLRtqradplVCAVGMLGSAI-FICLIFVAAKTSIVGAYICIFVGETLLFSnwAITAdILMY 449
Cdd:cd17325  246 LASALSQPPAGKLSDRIGRKP-------LILIGLLLSAVaLLLLPLATSFWLLLLLLALLGLGLGLVFP--ATLA-LLAD 315

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568973129 450 VVIPTRRATAVAL-QSFTShlLGDAGSPYLIGFISDLIrqstkdSPLWEFLSLGYALMLCPFVVVLG 515
Cdd:cd17325  316 IVPPEGRGTAMGLfNTAFS--LGMVLGPLLGGFLYDAF------GFATPFLAAAALLLLAAVLFLLL 374

MFS_ExuT_GudP_like

cd17319

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...

106-514

8.55e-25

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 106.50 E-value: 8.55e-25

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 106 AILSLGNVLNYLDRYTVAGVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSS 185
Cdd:cd17319    6 PLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALT 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 186 SFIpqQYFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVkQAAGDWHWALRV 265
Cdd:cd17319   86 GFA--TSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWL-LLLFGWRWAFII 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 266 SPVLGMITGTLILILVpatkrghadqlggqlkartswlrdmkalirnRSYVFSSLATSAVSFATGALGMWIPLYLHRAqv 345
Cdd:cd17319  163 EGLLGLLLAVLWWFYL-------------------------------RQVWGLALGYFGINYALYGLLTWLPTYLKQA-- 209

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 346 vqktaetcnsppcGAKDSLIFGAITCFTGFLGVVTGAGATRWCRLRTQRADPLVCAVGMLGSAIFICLIFVAakTSIVGA 425
Cdd:cd17319  210 -------------RGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRGARRLVIIIGLLLAAVGLLLAYLT--TSPVVA 274

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 426 YICIFVGETLLFSNWAITADILMYVVIPTRRATAVALQSFTSHLLGdAGSPYLIGFISDlirqsTKDSPLWEFLSLGyAL 505
Cdd:cd17319  275 VILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGG-FVAPLLIGYLVD-----ATGSYTAAFLFLA-AV 347


                 ....*....
gi 568973129 506 MLCPFVVVL 514
Cdd:cd17319  348 ALLAALLVL 356

ProP

COG0477

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...

94-384

1.50e-21

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];

Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 95.65 E-value: 1.50e-21

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129  94 PASLGRGRGAAAAILSLGNVLNYLDRYTVAGVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSC 173
Cdd:COG0477    5 DAAPTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLI 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 174 GIFFWSAVTFSSSFIPQqyFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVK 253
Cdd:COG0477   85 GLLLFGLASLLCGLAPS--PELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLV 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 254 QAAGdWHWALRVSPVLGMItGTLILILVPATKRGHADQLGGQLKARTSWLRDMKALIRNRSYVFSSLATSAVSFATGALG 333
Cdd:COG0477  163 AALG-WRWIFLINAPLGLL-ALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALL 240

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 568973129 334 MWIPLYLHRAQVVQKTAETCNSPPCGAKDSLIFGAITCFTGFLGVVTGAGA 384
Cdd:COG0477  241 LLLALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLL 291

MFS_NepI_like

cd17324

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...

107-342

5.15e-20

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 92.61 E-value: 5.15e-20

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 107 ILSLGNVLNYLDRYTVAGVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSS 186
Cdd:cd17324    3 ALALAAFAIGTTEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAA 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 187 FIPQqyFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGdWHWALRVS 266
Cdd:cd17324   83 LAPS--FALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLG-WRAAFLAI 159

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568973129 267 PVLGMITGTLILILVPATKRGHADQLGgqlkartsWLRDMKALIRNRSYVFSSLATSAVSFATGALGMWIPLYLHR 342
Cdd:cd17324  160 AVLALLAALLLWRLLPSLPPKKPGSLG--------LLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTD 227

2A0114

TIGR00893

D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ...

110-514

7.66e-20

D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]

Pssm-ID: 273326 [Multi-domain] Cd Length: 399 Bit Score: 92.40 E-value: 7.66e-20

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129  110 LGNVLNYLDRYTVAGVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIp 189
Cdd:TIGR00893   1 LVTVINYLDRANLSFAAPMLQEDLGLSAAQYGYVFSAFSWGYVVGQFPGGWLLDRFGARKTLAVFIVIWGVFTGLQAFA- 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129  190 qQYFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGY-ITGSSVkqAAGDWHWALRVSPV 268
Cdd:TIGR00893  80 -GAYVSLYILRVLLGAAEAPFFPGIILIVASWFPASERATAVSIFNSAQGLGGIIGGpLVGWIL--IHFSWQWAFIIEGV 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129  269 LGMITGTLILILVP----------------ATKRGHADQLGGQlkARTSWLRDMKALIRNRSYVFSSLATSAVSFATGAL 332
Cdd:TIGR00893 157 LGIIWGVLWLKFIPdppqkakwlteeekyiVVGGLLAEQQGKG--PSTPKKYQIKELLKDRRVWGLALGQFLVNIGLGFF 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129  333 GMWIPLYLHRAQVVQktaetcnsppcgAKDSLIFGAITCFTGFLGVVTGAGATRWCRLRTQR---ADPLVCAVGMLGS-A 408
Cdd:TIGR00893 235 LTWFPTYLVQERGLS------------ILEAGFMASLPGIVGFIGMILGGRLSDLLLRRGKSlvfARKTAIIAGLVLSlL 302

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129  409 IFICLIFVAAKTSIVGAYICIFvGETLLFSNWAITADILmyvvipTRRATAVALQSFtsHLLGDAGS---PYLIGFIsdl 485
Cdd:TIGR00893 303 MFATNYVNIPYAALALVALGFF-GLGAGAIGWALISDNA------PGNIAGLTGGLI--NSLGNLGGivgPIVIGAI--- 370

                         410       420
                  ....*....|....*....|....*....
gi 568973129  486 irQSTKDSPLWEFLSLGYALMLCPFVVVL 514
Cdd:TIGR00893 371 --AATTGSFAGALMVVAALALIGALSYLL 397

NarK

COG2223

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];

99-537

3.90e-19

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];

Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 90.33 E-value: 3.90e-19

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129  99 RGRGAAAAILSLGNVLNYLDRYTVAGVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFW 178
Cdd:COG2223    1 SGRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 179 SAVTFSSSFIPQqyFWLLVLSRGLVGIGE-ASYSTIAPTiIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAG 257
Cdd:COG2223   81 GIGLLLLALAVS--YWLLLLLGLLLGIGGgGSFAVGIAL-VSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFG 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 258 dWHWALRVSPVLGMITGTLILILVPATKRGHADqlggqlKARTSwLRDMKALIRNRSYVFSSLATSAVSFATGALGMWIP 337
Cdd:COG2223  158 -WRNAFLILGILLLVVAVLAWLFLRDPPAGAAA------AAKAS-LRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLP 229

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 338 LYLH-RAQVVQKTAetcnsppcgakdSLIFGAITCFTGFLGVVTGAGATRWCRLRTqradplvcAVGMLGSAIFICLIFV 416
Cdd:COG2223  230 PYLVdQFGLSAATA------------GLLAALFALLGALGRPLGGWLSDRIGGRRV--------LLIVFALMALGLLLLA 289

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 417 AAKTSIVGAYICIFVgetlLFSNWAITADILMYVV---IPTRRATAVALQSFTSHLLGDAGSPYLIGFISDlirqstkds 493
Cdd:COG2223  290 LALGSLWLFLVLFLL----LGLALGGGNGAVFALVpdiFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLD--------- 356

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....
gi 568973129 494 plwefLSLGYALmlcPFVVVLGGMFFLATALFFLSDRAKAEQQA 537
Cdd:COG2223  357 -----ATGSYTA---AFLVFAVLALVALVLTLLLYRRPRRAAAA 392

MFS_SV2_like

cd17316

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...

107-483

6.76e-19

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 88.81 E-value: 6.76e-19

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 107 ILSLGNVLNYLDRYTVAGVLLDIQQHF--GVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFS 184
Cdd:cd17316    3 LAGLGWFFDAYDFFLIGFVAPVLAAEFslGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 185 SSFIPQqyFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGDWhWALR 264
Cdd:cd17316   83 IGLLPT--PILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSGD-WGWR 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 265 VSPVLGMITGTLILilvpatkrghadqlggqlkartsWLRdmkalirnRSYVFSSLATSAVSFATGALGMWIPLYLhraq 344
Cdd:cd17316  160 ILFLIGALPALLAL-----------------------LLR--------RRTLLLILLWFFISFGYYGLTTFLPTYL---- 204

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 345 vvqktAETCNSPPcgAKDSLIFGAITCFTGFLGVVTGAGATRWCRLRTQradplvcAVGMLGSAIFICLIFVAAKTSI-- 422
Cdd:cd17316  205 -----QTVLGLSP--ATSSLYLLLISLGALVGALIAGLLSDRIGRKKTL-------VIGLILSGILALPLFYLLSGSPtl 270

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568973129 423 VGAYICIFVGETLLFSNwaiTADILMYVVIPTR-RATAVALQSFTSHLLGdAGSPYLIGFIS 483
Cdd:cd17316  271 LLLLLFILSFFVGGVWG---ALYAYLAELFPTEvRATGVGLSYNLGRLGG-GGAPPLIALLL 328

FucP

COG0738

Fucose permease [Carbohydrate transport and metabolism];

121-520

7.65e-19

Fucose permease [Carbohydrate transport and metabolism];

Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 89.14 E-value: 7.65e-19

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 121 TVAGVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIPQqyFWLLVLSR 200
Cdd:COG0738   26 LWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPS--YPLLLLAL 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 201 GLVGIGEASYSTIAPTIIGDLFTKNTRTLMlSVFYFAIPLGSGLGYITGSSV--KQAAGDWHWALrvspvlgMITGTLIL 278
Cdd:COG0738  104 FLLGLGLGLLDVAANPYVAALGPETAASRL-NLLHAFFSLGALLGPLLGGLLilLGLSLSWHLPY-------LILAVLLL 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 279 ILVPATKRGHADQLGGQLKARTSWLRDMKALIRNRSYVFSSLATSAVSFATGALGMWIPLYLHRAQvvqktaetcnsppc 358
Cdd:COG0738  176 LLALLFLRSKLPEIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVL-------------- 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 359 GAKDSLIFGAITCFTG--FLGVVTGAGATRWCRLRTqradplVCAVGMLGSAIFIcLIFVAAKTSIVGAYICIFVGetLL 436
Cdd:COG0738  242 GLSEATAALGLSLFWGgmTIGRFLGGFLLKRFGPVR------LLRLSALLAAVGL-LLALLAPGPWLALIGLALVG--LG 312

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 437 FSN-----WAITADILmyvviPTRRATAVALQSFTShLLGDAGSPYLIGFISDLIRqstkdsplwefLSLGYALMLCPFV 511
Cdd:COG0738  313 LSLmfptiFSLALDGL-----GKRTAAAVSAVLIMG-IVGGAIGPPLIGFLADAFG-----------LRAAFLVPLVCYL 375


                 ....*....
gi 568973129 512 VVLGGMFFL 520
Cdd:COG0738  376 LILLLALAL 384

MFS_YfmO_like

cd17474

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...

102-514

2.57e-17

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 84.54 E-value: 2.57e-17

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 102 GAAAAILSLGNVLnyldrytVAGVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAV 181
Cdd:cd17474    5 FFATLLAVLGVSI-------VDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIG 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 182 TFSSSFIPQqyFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVkqAAGDWHW 261
Cdd:cd17474   78 GLLCGLSDS--FALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLL--AAISWRY 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 262 ALRVSPVLGMITGTLILILVPATKRghadqlgGQLKARTSWLRDMKALIRNRSYVFSSLATSAVSFATGALGMWIPLYLH 341
Cdd:cd17474  154 PFFLLAALIPVAFLAILFLLPEPKE-------KAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLE 226

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 342 RAQVVqktaetcnsppcgakDSLIFGAITCFTGFLGVVTGAGATRWCRLRTQRADPLVcaVGMLGSAIFICLIFVAakTS 421
Cdd:cd17474  227 LLYGI---------------SPIIIGLLFAGWSVLLALGSLFVGRLLKKRFGARRILV--IGLLLYALSLLLLGFV--PS 287

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 422 IVGAYICIFVGETLLFSNWAITADILMYVVIPTRRATAVALQSFTsHLLGDAGSPYLIGFISDLIrqstkdSPLWEFLSL 501
Cdd:cd17474  288 LALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFV-RFLGQAVGPLLFGLLLEIF------GLSAPFLVG 360

                        410
                 ....*....|...
gi 568973129 502 GyALMLCPFVVVL 514
Cdd:cd17474  361 A-AIALAAAVLLA 372

MFS_SLC17A9_like

cd17380

Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ...

106-432

1.36e-16

Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 82.22 E-value: 1.36e-16

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 106 AILSLGNVLNYLDRYTVAGVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSS 185
Cdd:cd17380    2 ILLFLATCICYADRVNMPIAIVPMAKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLLT 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 186 SFIPQQYFWLLVLSRGLVGIGEA-SYSTIApTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGdWHWALR 264
Cdd:cd17380   82 PLLAYSSLPLLILSRILLGLGEGvHFPSMT-SLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYG-WPSVFY 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 265 VSPVLGMITGTLILILVPATkrghadqlggqlkartsWlrdmkALIrnrsyvfssLATSAVSFATGALGMWIPLYLHRAQ 344
Cdd:cd17380  160 FFGLLGLLWALVWLIYLPPV-----------------W-----AII---------VAHFCMNWGFYILLSWLPTYFHEVL 208

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 345 VVQktaetcnsppcgaKDSLIFGAITCFTGFL-GVVTGAGATRWC--RLRTQRADPLVCAVGMLGSAifICLIFVAAKTS 421
Cdd:cd17380  209 VPL-------------AKGWVFNVVPWLVMFPsSNVAGWLADHLIsrGWTVTSVRKLMQSIGFLGPA--LFLLLLSHTDS 273

                        330
                 ....*....|.
gi 568973129 422 IVGAYICIFVG 432
Cdd:cd17380  274 FSLALLCMSVA 284

MFS_arabinose_efflux_permease_like

cd17473

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...

121-483

8.09e-14

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 73.76 E-value: 8.09e-14

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 121 TVAGVLLDIQQHF-GVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIPQqyFWLLVLS 199
Cdd:cd17473   17 AIAPALPAIAQHFvPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDS--LYALLAS 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 200 RGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVkqAAGDWHWalrvsPVLGMITGTLILI 279
Cdd:cd17473   95 RALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGAL--AEIGWRA-----PFLVYLLALPVLI 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 280 LV------PATKRGHADQLGGQLKARTSWLRdmKALIrnrsyVFSSLATSAVSFatgALGMWIPLYLHRAQVVqktaetc 353
Cdd:cd17473  168 LVllflpePARKSKSAASPGAATAAALPWKR--VLPI-----YFLAFLAMLLFY---VIPIQLPFLLQERGGG------- 230

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 354 nsppcgakDSLIFGAITCFTGFLGVVtgaGATRWCRLRTQRADPLVCAVGMLGSAI-FICLIFVAAKTSIVGAYICIFVG 432
Cdd:cd17473  231 --------SAALIGLALAIASLAGAI---GALLFGRLKRRLGKRRLLAIGFALMALgFLLLALASGLWVVLLGAILAGLG 299

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|.
gi 568973129 433 ETLLFSNwaiTADILMYVVIPTRRATAVALQSfTSHLLGDAGSPYLIGFIS 483
Cdd:cd17473  300 FGLLLPT---LNSWAMSLVPPELRGRAMGIVT-SAFFLGQFLSPLVLGPLV 346

CynX

COG2807

Cyanate permease [Inorganic ion transport and metabolism];

87-485

1.03e-13

Cyanate permease [Inorganic ion transport and metabolism];

Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 73.75 E-value: 1.03e-13

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129  87 PSAPQPKPASLGRGRGAAAAILSLGNVLnyldRYTVAGV---LLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGD 163
Cdd:COG2807    3 TTSSSARRSRRAGRWLLLLAIVLVALNL----RPAITSVgplLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLAR 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 164 RFNRKVILSCGIFFWSAVTFSSSFIPQqyFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNtRTLMLSVFYFAIPLGSG 243
Cdd:COG2807   79 RFGLERTLLLALLLLAAGLLLRSLAPS--VALLLAGTALIGAGIAVGNVLLPGLIKRWFPDR-VGLMTGLYTAAMGLGAA 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 244 LGYITGSSVKQAAGdWHWALRVSPVLGMITgtlILILVPATKRGHADQlggqlkARTSWLRDMKALIRNRSYVFSSLATS 323
Cdd:COG2807  156 LAAGLTVPLAAALG-WRGALAVWALLALLA---LLLWLPLLRRRPAAA------AAAPAAASLRSLWRSPLAWLLTLFFG 225

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 324 AVSFATGALGMWIPLYLHRAQVVQKTAetcnsppcgakdslifGAITCFTGFLGVVTGAGATRWC-RLRTQRadPLVCAV 402
Cdd:COG2807  226 LQSLLYYAVVAWLPPILRDAGLSAATA----------------GLLLSLFQLAGIPGSLLVPLLAdRLGDRR--PLLLLL 287

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 403 GMLGSAIFICLIFVAAKTSIVGAyICIFVGETLLFSnwAITADILMYVVIPTRRATAVAL-QSFTShlLGDAGSPYLIGF 481
Cdd:COG2807  288 GLLGLAGLLGLLLAPGSLPWLWA-VLLGLGQGGLFP--LALTLIGLRARTPAEAAALSGMaQSVGY--LLAALGPLLVGA 362


                 ....
gi 568973129 482 ISDL 485
Cdd:COG2807  363 LHDA 366

MFS_FsR

cd17478

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...

108-520

1.83e-13

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 72.59 E-value: 1.83e-13

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 108 LSLGNVLNylDRYT--VAGVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSS 185
Cdd:cd17478    1 LSLGHFLN--DFYQgfLPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLL 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 186 SFIPQqyFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNtRTLMLSVFYFAIPLGSGLGYITGSSVKQaagdwHWALRV 265
Cdd:cd17478   79 GFAPN--YWLLLLLVALAGIGSAAFHPEGARLASQAAGGR-RGLAMSIFSVGGNLGFALGPLIAAALVA-----LFGGLG 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 266 SPVLGMITGTLILIL---VPATKRGHADQLGGQLKARTSWLRDMKALIR------NRSYVFSSLATsavsfatgalgmWI 336
Cdd:cd17478  151 LLILLIIPGLAVALLllrLRPLKKPEAKKAAAKSSARSTLKGVWRALLLlliivfLRSWVLSSLTT------------FL 218

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 337 PLYLHRAQVVQKTAETCNSPpcgakdSLIFGAITCFTGflgvvtGAGATRWCRLRtqradplVCAVGMLGSAIFICLIFV 416
Cdd:cd17478  219 PFYLVQRGYSLVFAGLLLSL------FLFAGAIGTLIG------GPLSDRFGRRR-------VIIASLLLAAPFLLLFLL 279

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 417 aakTSIVGAYICIFVGETLLFSNWAITadiLMYV--VIPTRRATAVALQ---SFTshlLGDAGSPyLIGFISDLIrqstk 491
Cdd:cd17478  280 ---TPGIWSYILLVLAGFLLFASFPVT---VVLAqeLLPGNVGLASGLMmglSFG---LGGIGAP-VLGALADAF----- 344

                        410       420
                 ....*....|....*....|....*....
gi 568973129 492 dsplweflSLGYALMLCPFVVVLGGMFFL 520
Cdd:cd17478  345 --------GLESVLLILALLPLLGALLAF 365

MelB

COG2211

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];

80-299

3.86e-12

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];

Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 69.16 E-value: 3.86e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129  80 CAAAAKGPSAPQPKPASLGRGRGAAAA-----ILSLGNVLNYLDRYTVAGVLL-DIQQHFGVKDRGAGLLQSVFICSFMV 153
Cdd:COG2211  200 TFFGTKERPVPEEEKVSLKESLKALLKnrpflLLLLAYLLFFLALALVAALLLyYFKYVLGLSAALVGLLLALYFLAALL 279

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 154 AAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIPQQYFWLLVLSRGLVGIGEASYSTIAPTIIGDL-------FTKNT 226
Cdd:COG2211  280 GAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGNLWLLLVLAALAGIGLGAILVLPWAMLADVvdydewkTGRRR 359

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 227 RTLMLSVFYFAIPLGSGLGYITGSSVKQAAG---------DWHWALRVS----PVLGMITGTLILILVPATKRGHAdQLG 293
Cdd:COG2211  360 EGLYFGIFTFAIKLGQALAGALAGLLLALFGyvagaaqspSALTGIRLLffllPAVLLLLAALLLLFYPLTRERHA-EIR 438


                 ....*.
gi 568973129 294 GQLKAR 299
Cdd:COG2211  439 AELAAR 444

Sugar_tr

pfam00083

Sugar (and other) transporter;

104-286

7.80e-12

Sugar (and other) transporter;

Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 68.07 E-value: 7.80e-12

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129  104 AAAILSLGNVLNYLDRYTVAGV--LLDIQQHFGVKDR-----GAGLLQSVFICSFMVAAPI----FGYLGDRFNRKVILS 172
Cdd:pfam00083   1 VALVAALGGFLFGYDTGVIGAFltLIDFFKNFGLSKSvsslaALSVLSGLIVSIFSVGCFIgslfAGKLGDRFGRKKSLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129  173 CGIFFWSAVTFSSSFIPQQY-FWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSS 251
Cdd:pfam00083  81 IANVLFVIGAVLQGAAKGKWsVYQLIVGRVLVGIGVGGASVLAPMYISEIAPKKLRGALGSLYQLAITFGILLAYIFGLG 160

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 568973129  252 VKQAAGDWHWalRVSPVLGMITGTLILIL---VPATKR 286
Cdd:pfam00083 161 LNKTSNSDGW--RIPLGLQLVPALLLIIGllfLPESPR 196

MFS_Tpo1_MDR_like

cd17323

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...

123-282

9.32e-12

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 67.60 E-value: 9.32e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 123 AGVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIPQqyFWLLVLSRGL 202
Cdd:cd17323   19 SPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPN--IAMLIILRFL 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 203 VGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGdWHWALRVSPVLGMITGTLILILVP 282
Cdd:cd17323   97 QGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLG-WRWIFWFLAIISGFCLILIFLFLP 175

MelB

COG2211

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];

152-544

1.04e-11

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];

Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 67.62 E-value: 1.04e-11

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 152 MVAAPIFGYLGDRFNRKV----------ILSCGIFFWsAVTFSSSFIPQQYFWLLVLSRGLVGIG----EASYSTIAPTI 217
Cdd:COG2211   60 AITDPLIGALSDRTRTRWgrrrpwiligAIPLALSFV-LLFTAPDLSPTGKLIYALVTYLLLGLAytlvNIPYSALGAEL 138

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 218 IGDlftKNTRTLMLSVFYFAIPLGSGLGYITGSS-VKQAAGDWHWALRVSPVLGMITGTL-ILILVPATKRGHADQlggq 295
Cdd:COG2211  139 TPD---YEERTRLSSWRFAFAGLGGLLASVLPPPlVAAFGGDAALGYRLTALIFAVLGLLaFLLTFFGTKERPVPE---- 211

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 296 lKARTSWLRDMKALIRNRSYVFSSLATSAVSFATGALGMWIPLYLhrAQVVQKTAETcnsppcgakdSLIFGAITCFTGF 375
Cdd:COG2211  212 -EEKVSLKESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYF--KYVLGLSAAL----------VGLLLALYFLAAL 278

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 376 LGV-VTGAGATRWCRLRTqradplvCAVGMLGSAIFICLIFVAAKTSIVGAYICIFV---GETLLFSN-WAITADILMYV 450
Cdd:COG2211  279 LGApLWPRLAKRFGKKKA-------FIIGLLLAALGLLLLFFLGPGNLWLLLVLAALagiGLGAILVLpWAMLADVVDYD 351

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 451 VIPT---RRATAVALQSFTSHlLGDAGSPYLIGFISDLIR-QSTKDSPLWEFLSLGYALMLCPFVVVLGGMFFLataLFF 526
Cdd:COG2211  352 EWKTgrrREGLYFGIFTFAIK-LGQALAGALAGLLLALFGyVAGAAQSPSALTGIRLLFFLLPAVLLLLAALLL---LFY 427

                        410
                 ....*....|....*...
gi 568973129 527 LSDRAKAEQQADEVPAQR 544
Cdd:COG2211  428 PLTRERHAEIRAELAARR 445

2A0104

TIGR00881

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...

110-485

1.45e-11

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]

Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 67.02 E-value: 1.45e-11

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129  110 LGNVLNYLDRYTVAGVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIP 189
Cdd:TIGR00881   2 IGYAAYYLVRKNFALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFST 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129  190 QqyFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGDWHWALRVSPVL 269
Cdd:TIGR00881  82 S--LWVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFGIAELYSWHWVFIVPGII 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129  270 GMITGTLILILV---PATK----------RGHADQLGGQLKARTSWLRDMKALIRNRSYVFSSLATSAVSFATGALGMWI 336
Cdd:TIGR00881 160 AIIVSLICFLLLrdsPQSCglppaeempnEEPDGDAEKKEEELTKKQIFLQYVLLNKVLWYISLGYVFVYVVRTGILDWS 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129  337 PLYLhrAQVVQKTAETCNSppcgakdslifgAITCFtgFLGVVTGAGATRWCrlrtqrADPLVCAVGMLGSAIFICLIFV 416
Cdd:TIGR00881 240 PLYL--TQEKGFSKEKASW------------AFTLY--ELGGLVGTLLAGWL------SDKLFNGRRGPLAVFFMALIIV 297

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568973129  417 A-------AKTSIVGAYICIFVGETLLFSNWAITADILMYVVIPTRRATAVALQSFTSHLLGDAgSPYLIGFISDL 485
Cdd:TIGR00881 298 SllvywlnPAANPLMDLICLFALGFLVYGPQMLIGVIASELAPKKAAGTAAGFVGFFAYLGGIL-AGLPLGYLADG 372

OATP

pfam03137

Organic Anion Transporter Polypeptide (OATP) family; This family consists of several ...

129-416

6.94e-11

Organic Anion Transporter Polypeptide (OATP) family; This family consists of several eukaryotic Organic-Anion-Transporting Polypeptides (OATPs). Several have been identified mostly in human and rat. Different OATPs vary in tissue distribution and substrate specificity. Since the numbering of different OATPs in particular species was based originally on the order of discovery, similarly numbered OATPs in humans and rats did not necessarily correspond in function, tissue distribution and substrate specificity (in spite of the name, some OATPs also transport organic cations and neutral molecules). Thus, Tamai et al. initiated the current scheme of using digits for rat OATPs and letters for human ones. Prostaglandin transporter (PGT) proteins are also considered to be OATP family members. In addition, the methotrexate transporter OATK is closely related to OATPs. This family also includes several predicted proteins from Caenorhabditis elegans and Drosophila melanogaster. This similarity was not previously noted. Note: Members of this family are described (in the Swiss-Prot database) as belonging to the SLC21 family of transporters.

Pssm-ID: 460821 [Multi-domain] Cd Length: 526 Bit Score: 65.30 E-value: 6.94e-11

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129  129 IQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAvtfsSSFI---PqqYFWLLVLSRGLVGI 205
Cdd:pfam03137  27 IEKRFGLPSSLSGLISSSYDIGNLLLIVFVSYFGGKGHRPRWIGVGALLMGL----GSLLfalP--HFLSFFLGQLLLGI 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129  206 GEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGDWH-WALRVSPV---------LGMITGT 275
Cdd:pfam03137 101 GGTPIYTLGISYIDDNVKKKNSPLYLGILYAVRVLGPALGFLLGSLCLRIYVDIGkVSITLTPKdprwvgawwLGFLIAG 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129  276 LILILV------------------------PATKRGHADQLGGQLKARTSWLRD----MKALIRNRSYVFSSLATsaVSF 327
Cdd:pfam03137 181 LLLLLTaipffffpkslpgaakrrakkkkePHSQDIADLKKTKSLKKLGPSLKDfpkaLKRLLKNPVYMLLTLAS--VFE 258

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129  328 ATGALGMWI--PLYLhrAQVVQKTAetcnsppcgAKDSLIFGAITCFTGFLGVVTGAGATRWCRLRTQRADPLVCAVGML 405
Cdd:pfam03137 259 FLLIAGYATflPKYI--ETQFGLSA---------STANLLTGVVAIPGAALGILLGGLIIKKFKLSAKGLAKFNVITSLV 327

                         330
                  ....*....|.
gi 568973129  406 GSAIFICLIFV 416
Cdd:pfam03137 328 SLLLSLLLFFL 338

MFS_FucP_MFSD4_like

cd17333

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ...

121-512

7.47e-11

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 64.65 E-value: 7.47e-11

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 121 TVAGVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRK--VILSCGIFfwsaVTFSSSFIPQQYFWLLVL 198
Cdd:cd17333   14 LLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRrtLILGLLLI----SLALALIFATPSIYLFVV 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 199 SRGLVGIGEASYSTIAPTIIGDLFtKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGDWHWALrvspvlgMITGTLIL 278
Cdd:cd17333   90 LMFLAGLGAGILDTGANTFVGALF-EESSATRLNVLHGFFGLGALIGPLIATSLLTSELSWSWAY-------LIIGLIYL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 279 ILVPATKRGHADQLGG---QLKARTSWLRDMKALIRNRSYVFSSLATSAVSFATGALGMWIPLYLHRAQVVqktaetcns 355
Cdd:cd17333  162 LLAILILLTLFPELPSarnPQQSVGAFSASASRLLRNPSIILGALALFLYVGAETAFSSWVPSYLVEKKHV--------- 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 356 ppcGAKDSLIFGAITCFTGFLGVVTGAGATRwcrlrtqRADPLVCAVGMLGSAIFICLIFVAAKTSIVGAYICIFVGetL 435
Cdd:cd17333  233 ---SDGLAGYLLSGFWVGITIGRLLGGPISR-------RIKPHTLLVLSGSGALLGLLILLLAPTLVVGLVATALLG--L 300

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568973129 436 LFSNWAITADILMYVVIPTRRATAVALQSfTSHLLGDAGSPYLIGFIsdlIRQSTKDSPLWEFLSLgYALMLCPFVV 512
Cdd:cd17333  301 FMAALFPTILSLGISNLPYAKGKGTSVLL-AAGSIGGAIIPFIMGFI---AEAVGIQTAMLLITIL-YAIIFVLALL 372

MFS_MMR_MDR_like

cd17504

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...

122-277

7.49e-11

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 64.52 E-value: 7.49e-11

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 122 VAGVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIPQqyFWLLVLSRG 201
Cdd:cd17504   15 LSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPN--LPVLIAGRA 92

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568973129 202 LVGIGEASYsTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGdWHWALRVSPVLGMITGTLI 277
Cdd:cd17504   93 LQGIGGAVF-PLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLG-WRWIFWTAAPVAVLLAALV 166

MFS_MdtH_MDR_like

cd17329

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...

153-485

8.22e-11

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 64.56 E-value: 8.22e-11

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 153 VAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIPQqyFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLS 232
Cdd:cd17329   50 VASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHS--PWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFS 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 233 VFYFAIPLGSGLGYITGSSVKQAAGDW-HWALRVSPVLGMItgtLILILVPATKRGHADQlggqlkARTSWLRDMKALIR 311
Cdd:cd17329  128 LLYWAINLGVAIGPLLGGLLLLYSFRLlFLAAAVLFLLAAL---VLLFLLPETRPKRRAA------EKTEILRGYKIVLR 198

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 312 NRSYVFSSLATSAVSFATGALGMWIPLYLHRAQVVQktaetcnsppcgakdSLIFGAITCFTGFLGVVTGAGATRWCRLR 391
Cdd:cd17329  199 DRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLG---------------ESLLGLLLALNALLIVLLQFPVARLVERF 263

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 392 TQRADPLVCAVGMlgSAIFICLIFVAAKTSIVGAYICIFVGETLLFSnwaiTADILMYVVIPTRRA---TAVALQSFTsh 468
Cdd:cd17329  264 RLRKILMIGILLF--AIGFAVLAFANTLAVLILAMIVLTLGEMLVFP----AVQTLVAALAPPDKRgsyMGFYALAWG-- 335

                        330
                 ....*....|....*..
gi 568973129 469 lLGDAGSPYLIGFISDL 485
Cdd:cd17329  336 -LGRAIGPLVGGLLLDL 351

MFS_YfcJ_like

cd17489

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...

131-339

1.07e-10

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 64.15 E-value: 1.07e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 131 QHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIPQqyFWLLVLSRGLVGIGEASY 210
Cdd:cd17489   24 HDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATS--VALLLVLRLIHGIGWGAF 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 211 STIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGdwHWALRVSPVLGMITGTLILILVPATKRGHad 290
Cdd:cd17489  102 TTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLG--FAVLFIVAAVLALLALLLVFLVKDPPPVA-- 177

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 568973129 291 qlggqlKARTSWLRDMKALIRNRSYVFSSLATSAVSFATGALGMWIPLY 339
Cdd:cd17489  178 ------AEEAEAGTRAFRRLVEKKVLPPALILFLASIAYGAISTFLPLY 220

MFS_MdtG_SLC18_like

cd17325

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...

127-281

1.36e-10

Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 63.75 E-value: 1.36e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 127 LDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIPQqyFWLLVLSRGLVGIG 206
Cdd:cd17325  224 LYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATS--FWLLLLLLALLGLG 301

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568973129 207 EASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGdWHWALRVSPVLGMITGTLILILV 281
Cdd:cd17325  302 LGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFG-FATPFLAAAALLLLAAVLFLLLR 375

MFS_MucK

cd17371

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...

110-522

1.83e-10

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 63.48 E-value: 1.83e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 110 LGNVLNYLDRYTVAGVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIp 189
Cdd:cd17371    6 LGWALDGFDLLLLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFA- 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 190 qQYFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGDwHWALRVSPVL 269
Cdd:cd17371   85 -QNYWQLLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLFPLLPP-EIAWRVLFLL 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 270 GMITGTLILIL---VPATKRGHADQLGGQLKARTSWLRDMKALIRNRSYVFSSLATSAVSFATGALGMWIPLYLHRAQVV 346
Cdd:cd17371  163 GALPALLVLFIrrfVKEPPQWQAARAARRHFADRPSLRELFSPPLLRTTLLASLLATGALGGYYGITTWLPSYLTGERGL 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 347 QktaetcnsppcgAKDSLIFGAITCFTGFLG-VVTGAGATRWCRLRTqradplvCAVGMLGSAIFICLIFVAAKTSIVGA 425
Cdd:cd17371  243 S------------FEGSAGYLVVTILGGFLGyLAGGFLADRIGRRNN-------FALFALGSAISILLYFFLPLSPTLIL 303

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 426 YICIFVGETL--LFSNWAitadILMYVVIPTR-RATAVALQSFTSHLLGdAGSPYLIGFISDLIrqstkdsplweflSLG 502
Cdd:cd17371  304 ILGFPLGFFAsgPFSGMG----AYLTELFPTAvRATAQGFCYNVGRIIG-ALFPFLVGFLATSG-------------SLG 365

                        410       420
                 ....*....|....*....|...
gi 568973129 503 YALML---CPFVVVLGGMFFLAT 522
Cdd:cd17371  366 TAIAVfaaVYYIAGLVLALLLPE 388

MFS_MMR_MDR_like

cd17321

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...

108-469

2.40e-09

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 59.88 E-value: 2.40e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 108 LSLGNVLNYLDRYTVAGVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSF 187
Cdd:cd17321    1 LLLAVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCAL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 188 IPQqyFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGdWHWALRVSP 267
Cdd:cd17321   81 APS--LAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFG-WRWIFLINV 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 268 VLGMItgtlILILVpatkrghadqlggqlkartswlrdmkalirnRSYVFSSLATSAVSFATGALGMWIPLYLhraQVVQ 347
Cdd:cd17321  158 PIGLV----ALLLA-------------------------------RTFSGAVLAAFLLGAALGGLLFLLPLYL---QGVL 199

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 348 ktaetcNSPPCGAkdSLIFGAITCFTGFLGVVTGAGATRWCRLRTQRADPLVCAVGMLGSAIficLIFVAAKTSIVGAYI 427
Cdd:cd17321  200 ------GYSPLQA--GLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLAL---LGADSSVWLLLPGLV 268

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|..
gi 568973129 428 CIFVGETLLfsnWAITADILMYVVIPTRRATAVALQSFTSHL 469
Cdd:cd17321  269 LLGLGLGLF---ATPLTNAALSSVPKEKAGAASGILNTARQL 307

MFS_HMIT_like

cd17360

H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ...

122-286

3.55e-09

H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340918 [Multi-domain] Cd Length: 362 Bit Score: 59.21 E-value: 3.55e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 122 VAGVLLDIQQHFGVKDRGAG---LLQSVFICSFMVAAPIFGYLGDRFNRK--VILSCGIFFWSAVTFSSSfipqQYFWLL 196
Cdd:cd17360   16 ISGALLYIKDDLGEVVLSTGwqeLIVSSTVAGAAVGAAIGGWLNDRFGRRpcILLADALFTIGAIVMAAA----PNKEVL 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 197 VLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGDWHWALRVSPVLGMITGTL 276
Cdd:cd17360   92 IVGRVLVGLGVGIASMTVPLYIAEAAPPRIRGRLVTINVLFITGGQFVAYVINGAFSYLPGGWRWMLGLAAVPAVLQFIG 171

                        170
                 ....*....|
gi 568973129 277 ILILvPATKR 286
Cdd:cd17360  172 LLFL-PESPR 180

MFS_SLC46_TetA_like

cd17330

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...

140-286

1.03e-08

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 57.59 E-value: 1.03e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 140 AGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFwSAVTFSSSFIpQQYFWLLVLSRGLVGIGeASYSTIAPTIIG 219
Cdd:cd17330   36 VGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAG-SAVSYVLLGL-SRNLWLLFLARFLDGLT-GGNVSVAQAYIA 112

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568973129 220 DLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGDwHWALRVSPVLGMITGTLILILVPATKR 286
Cdd:cd17330  113 DITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGY-ALPFLVAAALALLNLVLVLFFLPPLRR 178

MFS_PcaK_like

cd17365

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...

108-284

1.20e-08

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 57.60 E-value: 1.20e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 108 LSLGNVLNYLDRY--TVAGVLL-DIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFS 184
Cdd:cd17365    1 LALCFLIIVLDGFdlAVMGFVApALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 185 SSFIPQqyFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGdWHWALr 264
Cdd:cd17365   81 TAFAQS--VLQLALLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFG-WRSVF- 156

                        170       180
                 ....*....|....*....|
gi 568973129 265 vspVLGMITGTLILILVPAT 284
Cdd:cd17365  157 ---LLGGVPPLILLPLLRGT 173

MFS_SLC22

cd17317

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...

144-250

1.45e-08

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 57.21 E-value: 1.45e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 144 QSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIPqqYFWLLVLSRGLVGIGEASYSTIAPTIIGDLFT 223
Cdd:cd17317   31 QTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSP--SYELFLVLRFLVGVTSAGIFTVGFVLGMEIVG 108

                         90       100       110
                 ....*....|....*....|....*....|.
gi 568973129 224 KNTRTLMLSVFYFAIPLG----SGLGYITGS 250
Cdd:cd17317  109 PKYRSFVGILFGLFWALGymllALLAYLIRD 139

MFS_GLUT_like

cd17315

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...

109-280

1.48e-08

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 57.20 E-value: 1.48e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 109 SLGNVLNYLDRYTVAGVLLDIQQHFGVKdrGAGLLQSVFICSFMVAAPI----FGYLGDRFNRKVILSCGIFFWSAVTFS 184
Cdd:cd17315    3 ALGGLLFGYDLGVINGALLYIAKDLGFG--LSTSLQGLVVSSLLLGAAIgslfGGPLADRFGRRKSLLIAAVLYVIGALL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 185 SSFIPQqyFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQ-AAGDWHWAL 263
Cdd:cd17315   81 SALAPN--VWVLIVGRFLLGLGVGLASVLVPLYISEIAPAKIRGALGTLNQLMITFGILLAYLLGLALSLsPPGWWRLMF 158

                        170
                 ....*....|....*..
gi 568973129 264 RVSPVLGMITGTLILIL 280
Cdd:cd17315  159 ALAAVPALLQLLLMFFL 175

MFS_SLCO_OATP

cd17336

Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; ...

124-250

1.75e-08

Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; Solute carrier organic anion transporters (SLCOs) are also called organic anion transporting polypeptides (OATPs) or SLC21 (Solute carrier family 21) proteins. They are sodium-independent transporters that mediate the transport of a broad range of endo- as well as xenobiotics. Their substrates are mainly amphipathic organic anions with a molecular weight of more than 300Da, although there are a few known neutral or positively charged substrates. These include drugs including statins, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, antibiotics, antihistaminics, antihypertensives, and anticancer drugs. SLCOs/OATPs can be classified into 6 families (SLCO1-6 or OATP1-6) and each family may have subfamilies (e.g. OATP1A, OATP1B, OATP1C). Within the subfamilies, individual members are numbered according to the chronology of their identification and if there is already an ortholog known, they are given the same number. For example, the first SLCO identified, is rat OATP1A1 (encoded by the Slco1a1 gene). The second SLCO identified is the first human SLCO from the same subfamily and is called OATP1A2 (encoded by the SLCO1A2 gene). There are 11 human SLCOs/OATPs. SLCOs belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340894 [Multi-domain] Cd Length: 411 Bit Score: 57.25 E-value: 1.75e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 124 GVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFwSAVTFSSSFIPQqyfwLLVLSRGLV 203
Cdd:cd17336   24 STITTIEKRFGLSSSQSGLILSANDIGQLLAVLLVSYFGGRGHRPRWIGIGSIL-MGLGCFLLALPH----FLFVGQFLL 98

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 568973129 204 GIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGS 250
Cdd:cd17336   99 GIGSSPLYTLGITYIDDNVSKKNSPLYIGILYAMRVLGPALGFLLGS 145

2A0119

TIGR00898

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]

140-280

8.98e-08

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]

Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 55.41 E-value: 8.98e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129  140 AGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIPqQYFWLLVLsRGLVGIGEASYSTIAPTIIG 219
Cdd:TIGR00898 129 VDLTQSCFFVGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSP-NYTVFLVF-RLLVGMGIGGIWVQAVVLNT 206

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568973129  220 DLFTKNTRTL--MLSVFYFAIplgsglGYITGSSVKQAAGDWHWALRVSPVLGMITGTLILIL 280
Cdd:TIGR00898 207 EFLPKKQRAIvgTLIQVFFSL------GLVLLPLVAYFIPDWRWLQLAVSLPTFLFFLLSWFV 263

MFS_DtpA_like

cd17346

Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily ...

140-280

1.20e-07

Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily of transporters; The DtpA-like subfamily includes four Escherichia coli proteins: dipeptide and tripeptide permeases A (DtpA, TppB or YdgR), B (DtpB or YhiP), C (DtpC or YjdL), and D (DtpD or YbgH). They are proton-dependent permeases that transport di- and tripeptides. DtpA and DtpB display a preference for di- and tripeptides composed of L-amino acids. DtpC shows higher specificity for dipeptides compared to tripeptides, and prefers dipeptides containing a C-terminal lysine residue. The DtpA-like subfamily belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340904 [Multi-domain] Cd Length: 399 Bit Score: 54.50 E-value: 1.20e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 140 AGLLQSVFiCSFMVAAPIF-GYLGDRF--NRKVILSCGIFFwsAVTFSSSFIPQQYFWLLVLSRGLVGIGEASYSTIAPT 216
Cdd:cd17346   42 AASIYGAY-TALVYLTPIIgGWLADKVlgARRTVFIGGILM--ALGYLLLALSPFSVSMLYLGLALIIVGNGLFKPNISS 118

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568973129 217 IIGDLFTKN--TRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGdWHWALRVSPVlGMITGTLILIL 280
Cdd:cd17346  119 LVGKLYDENdpRRDSGFSIFYMGINLGAFLAPLLCGTLGDNYG-YHYGFGLAAV-GMLLGLLIFLL 182

MFS_OPA_SLC37

cd17312

Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ...

110-281

1.53e-07

Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 54.20 E-value: 1.53e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 110 LGNVLNYLDRYTVAGVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIP 189
Cdd:cd17312   10 LGYAAYYVCRKNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFST 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 190 QqyFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQaAGDWHWALRVSPVL 269
Cdd:cd17312   90 S--LWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLAS-YYGWRAAFLVPGIV 166

                        170
                 ....*....|..
gi 568973129 270 GMITGTLILILV 281
Cdd:cd17312  167 GLVVAIILFFFL 178

UhpC

COG2271

Sugar phosphate permease [Carbohydrate transport and metabolism];

107-286

2.13e-07

Sugar phosphate permease [Carbohydrate transport and metabolism];

Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 53.72 E-value: 2.13e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 107 ILSLGNVLNYLDRYTVAGVLLDI-QQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSS 185
Cdd:COG2271  184 LLALAYFLVYFALYGFLTWLPTYlVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALALL 263

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 186 SFIPQQYFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGdWHWALRV 265
Cdd:COG2271  264 LLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATG-YQAAFLL 342

                        170       180
                 ....*....|....*....|.
gi 568973129 266 SPVLGMITGTLILILVPATKR 286
Cdd:COG2271  343 LAALALLAALLALLLLRETRK 363

MFS_LmrB_MDR_like

cd17503

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...

121-527

2.30e-07

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 53.73 E-value: 2.30e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 121 TVAGVLL-DIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKvilscGIFFWSAVTF-SSSFIP--QQYFWLL 196
Cdd:cd17503   13 TIVNVALpTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTR-----RLFLTALALFtLGSLLCglAPNLASL 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 197 VLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGdWHWALRVSPVLGMItgtl 276
Cdd:cd17503   88 IIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLS-WRWIFYINLPIGIL---- 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 277 ILILVPatkrghadqlggqlkartswLRDMKALiRNRSYVFSSLATSAVSFATGALGMWIPLYLhraQVVQK-TAETcns 355
Cdd:cd17503  163 ALLLAP--------------------LLDLRLF-KDRNFTLGLLLSFLLGLGLFGAMFLLPLYL---QNVLGySAFE--- 215

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 356 ppcgAKDSLIFGAItcFTGFLGVVTGAgatrwcrlRTQRADP-LVCAVGMLGSAIFICLIFVAAKTS----IVGAYICIF 430
Cdd:cd17503  216 ----SGLVLAPGGL--ASAILSPLVGR--------LLDKFGPrLLLLAGLLLLALGTLLLAFLTPDTslwlIILPLFIRG 281

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 431 VGETLLFSnwAITADILMYVViPTRRATAVALQSFTSHLLGDAGSPYLIGFISDLIRQSTKDSPLWEFLSLGYALMLCPF 510
Cdd:cd17503  282 LGMGLVFM--PLNTLALNSLP-PEQIGDATALFNTIRQLGGSIGTALLATLLTNRTQFHHSRLSELLAQQVQKQALIIAF 358

                        410
                 ....*....|....*....
gi 568973129 511 VV--VLGGMFFLATALFFL 527
Cdd:cd17503  359 NDafLVSAILLLVGLLLAL 377

MFS_GLUT6_8_Class3_like

cd17358

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ...

152-304

2.66e-07

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340916 [Multi-domain] Cd Length: 436 Bit Score: 53.73 E-value: 2.66e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 152 MVAAPIFGYLGDRFNRK-VILSCGIFF---WSAVTFSSSFipqqyfWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTR 227
Cdd:cd17358   55 LIGALLSGKLADRIGRKrTLLISAIPCilgWLLIAFAKDV------WMLYLGRFLAGFGGGAASVVVPVYIAEIAPKNVR 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 228 TLMLSVFYFAIPLGSGLGYITGSSVkqaagdwHWalRVSPVLGMI---TGTLILILVPAT-----KRGHADQLGGQLKar 299
Cdd:cd17358  129 GALGSLNQLLVNIGILLGYVLGSFL-------PW--RTLALIGAIppvVFLILLFFIPESprwlaKKGREEEAEKSLQ-- 197


                 ....*
gi 568973129 300 tsWLR 304
Cdd:cd17358  198 --FLR 200

MFS_MdfA_MDR_like

cd17320

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...

118-484

3.43e-07

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 52.96 E-value: 3.43e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 118 DRYTVAgvLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIPQqyFWLLV 197
Cdd:cd17320   16 DMYLPA--LPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASS--IEQLL 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 198 LSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLS----VFYFAIPLGSGLGyitgsSVKQAAGDWHWALRVSPVLGMIT 273
Cdd:cd17320   92 IARFLQGLGAAAGSVVARAIVRDLYSGAELAKIFSllmmILAIAPALAPLLG-----GLLLLFFGWRAIFVFLALLGLLL 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 274 GTLILILVPATKRGHAdqlGGQLKARTswLRDMKALIRNR---SYVFSSLATSAVSFATGALGMWI---PLYLHRAQVvq 347
Cdd:cd17320  167 LLLVLLFLPETLPEEK---RKPLLSSL--LRAYKRVLKNRrflGYALALGLSFAGLFAYLAAAPFIyieQLGLSPAQF-- 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 348 ktaetcnsppcgakdSLIFGAItcftgFLGVVTGAGATRwcRLRTQRADPLVCAVGMLGSAIFICLIFVAAKT------S 421
Cdd:cd17320  240 ---------------GLLFALN-----AIALILGSLLNG--RLVRRFGPRRLLRLGLLLLLAAALVLLLAALLgglslwP 297

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568973129 422 IVGAYICIFVGETLLFSNwaitADILMYVVIPTRRATAVALQSFTSHLLGDAGSpYLIGFISD 484
Cdd:cd17320  298 LVAPLFLIFFGFGLIFPN----ATSLALEPFPHVAGTASALLGFLQFLIGALAG-ALVGLLPN 355

MFS_XylE_like

cd17359

D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ...

122-286

5.46e-07

D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 52.57 E-value: 5.46e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 122 VAGVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRK--VILSCGIFFWSAV--TFSSSFipqqyfWLLV 197
Cdd:cd17359   20 INGALPFLQTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRktLLISAVLFFISALgsAFSPNF------TIFI 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 198 LSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGD-------WHWALRVSPVLG 270
Cdd:cd17359   94 IARIIGGLAVGGASALVPMYIAEVAPAEIRGRLVSLNQLMIVFGQLLAYIVNYLIANAGGAdwlgaegWRWMLGLEAIPA 173

                        170
                 ....*....|....*.
gi 568973129 271 MITGtLILILVPATKR 286
Cdd:cd17359  174 ILFL-LGMLFIPESPR 188

MFS_MT3072_like

cd17475

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...

129-501

1.10e-06

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 51.47 E-value: 1.10e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 129 IQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFipQQYFWLLVLSRGLVGIGea 208
Cdd:cd17475   22 LQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMAL--VGSYPVLLVLLFLVGAG-- 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 209 sYSTIAPT---IIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGdWHWALRVSPVLGMITGTLILilvpatk 285
Cdd:cd17475   98 -YGSVQPGggrAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYG-WRAAFVVAGLVSILAAVLFW------- 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 286 RGHADQLGGQLKARTS--WLRDMKALIRNRSYVFSSLATSAVSFATGALGMWIPLYLHRAQVVqktaetcnSPPCGAkds 363
Cdd:cd17475  169 LFYREPPAASAATESAstLLRSLKEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGL--------SVVAAG--- 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 364 lIFGAITCFTGFLGVVTGAGATRwcRLRTQRADPLVCAVGMLGSAIFICLIFVAAKTSIVGAY-ICIFVGetLLFSNWAI 442
Cdd:cd17475  238 -ALLAVAQLGGALGRIGLGRVSD--RVFGGRRRPVLVITAAIAAAALLVLSLLSPGTPLWLLVlLLILLG--LFAIGWNG 312

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 443 TADILMYVVIPTRRA-TAVALqSFTSHLLGDAGSPYLIGFISDlirQSTKDSPLWEFLSL 501
Cdd:cd17475  313 LYLTLVAESAGPEQAgTALGL-ANTINFIGIAIGPPLFGLLVD---ATHSYAPAWLALAL 368

MFS_MJ1317_like

cd17370

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...

103-252

2.18e-06

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 50.62 E-value: 2.18e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 103 AAAAILSLGNvlnyldrYTVAGVLLDIQQhFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVT 182
Cdd:cd17370  207 LAVALFALGN-------FSFAFLILRAQE-LGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAY 278

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 183 FssSFIPQQYFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFaiplGSGLGYITGSSV 252
Cdd:cd17370  279 L--GFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGLFNT----VVGIGWLLASLI 342

MFS_OAT

cd17374

Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ...

144-261

4.00e-06

Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340932 [Multi-domain] Cd Length: 341 Bit Score: 49.60 E-value: 4.00e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 144 QSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIPQqyFWLLVLSRGLVGIGEASYSTIAPTIIGDLFT 223
Cdd:cd17374   41 QSIFMAGLLVGALIFGHLSDRFGRKFILLLSLLQLAIFGTCAAFAPT--FPVYCVLRFLAGFAVSGISINTLILGTEWTT 118

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 568973129 224 KNTRTLM--LSVFYFAIplgsglGYITGSSVKQAAGDWHW 261
Cdd:cd17374  119 PRHRALAitLTSCFFSI------GQMLLAGLAYAIRDWRL 152

2A0115

TIGR00895

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...

94-461

9.49e-06

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]

Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 48.51 E-value: 9.49e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129   94 PASLGRGRGAAAAILSLGNVLNYLDRYTVAGVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSC 173
Cdd:TIGR00895   8 KQPLSRYQWRAIILSFLIMLMDGYDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLW 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129  174 GIFFWSAVTFSSSFipQQYFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLG-SGLGYITGSSV 252
Cdd:TIGR00895  88 SILLFSVFTLLCAL--ATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGaAVGGFLAGWLI 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129  253 kqAAGDWHWALRVSPVLGMITGTLILILVP----------------------ATKRGHADQLGGQLKARTSWLRDMKALI 310
Cdd:TIGR00895 166 --PVFGWRSLFYVGGIAPLLLLLLLMRFLPesidflvskrpetvrrivnaiaPQMQAEAQSALPEQKSTQGTKRSVFKAL 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129  311 ----RNRSYVFSSLATSAVSFATGALGMWIPLYlhraqvvqkTAETCNSPpcgaKDSLIFGAITCFTGFLGVVTGAGAtr 386
Cdd:TIGR00895 244 fqgkTARITVLLWLLYFMLLVGVYFLTNWLPKL---------MVELGFSL----SLAATGGALFNFGGVIGSIIFGWL-- 308

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568973129  387 wcrlrTQRADPLVCAVGMLGSAIFICLIFVAAKTSIVGAYICIFVGetlLFSNWAITADI-LMYVVIPTR-RATAVA 461
Cdd:TIGR00895 309 -----ADRLGPRVTALLLLLGAVFAVLVGSTLFSPTLLLLLGAIAG---FFVNGGQSGLYaLMALFYPTAiRATGVG 377

MFS_SVOP_like

cd17372

Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ...

106-272

1.12e-05

Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340930 [Multi-domain] Cd Length: 367 Bit Score: 48.30 E-value: 1.12e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 106 AILSLGNVLNYLDRYTVAGVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGiFFWSAV-TFS 184
Cdd:cd17372    2 AYAGMGWVAEAMEMMLLSFVGPAVQCEWNLSAWQVALITSVVFAGMMIGSYLWGIVSDKYGRRKGLIIS-ALWTFYaGFL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 185 SSFIPqQYFWLLVLsRGLVGIGEASYSTIApTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGdWHWALR 264
Cdd:cd17372   81 SAFAP-NYMWLIIL-RCLVGLGLGGGPQLA-SWYLEFLPAKSRGTWMVLFSVFWTVGTIFEASLAWLVMPRLG-WRWLLA 156


                 ....*...
gi 568973129 265 VSPVLGMI 272
Cdd:cd17372  157 FSSVPSSL 164

MFS_FEN2_like

cd17327

Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ...

107-282

2.05e-05

Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 47.63 E-value: 2.05e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 107 ILSLGNVLNYLDRYTVA-GVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSS 185
Cdd:cd17327    9 LLCILYFLQYLDKSNISnAAVMGMKEDLKLVGNQYNWGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGLLTLLT 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 186 SFIpqQYFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGS--------GLGYITGSSVKQaag 257
Cdd:cd17327   89 AAV--KNFGGLIALRFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLGSifggllayGVFKILGVGGLA--- 163

                        170       180
                 ....*....|....*....|....*
gi 568973129 258 DWHWALRVSPVLGMITGTLILILVP 282
Cdd:cd17327  164 GWRWLFIIEGLITIIIGLVIFFWLP 188

MFS_1

pfam07690

Major Facilitator Superfamily;

129-245

3.95e-05

Major Facilitator Superfamily;

Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 46.64 E-value: 3.95e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129  129 IQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIP-QQYFWLLVLSRGLVGIGE 207
Cdd:pfam07690 226 YQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSlTLSSLWLLLALLLLGFGF 305

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 568973129  208 ASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLG 245
Cdd:pfam07690 306 GLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALG 343

MFS_MFSD6

cd17335

Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ...

131-215

4.58e-05

Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 46.42 E-value: 4.58e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 131 QHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFN-RKVILSCGIFFWSAVTFSSSFIPQQYFWLLVlsrgLVGIGEAS 209
Cdd:cd17335   25 KQLGLSPTQIGILIGIRPFVRFLSAPLWGALADRFGkRKALLLLSLLAAVLFFLSLFFVAQIFWLLLL----LVILGAFF 100


                 ....*.
gi 568973129 210 YSTIAP 215
Cdd:cd17335  101 SAPVVP 106

MFS_SLCO5_OATP5

cd17404

Solute carrier organic anion transporter 5 family of the Major Facilitator Superfamily of ...

123-250

4.92e-05

Solute carrier organic anion transporter 5 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 5 (SLCO5) or Organic anion transporting polypeptide 5 (OATP5) family contains only one subfamily, OATP5A, which contains only one mammalian member OATP5A1 (encoded by SLCO5A1). Deletion of the SLCO5A1 gene has been implicated in the pathogenesis of Mesomelia-synostoses syndrome (MSS), a rare autosomal-dominant disorder characterized by mesomelic limb shortening, acral synostoses, and multiple congenital malformations. OATP5A1 may be a non-classical OATP which is involved in biological processes that require the reorganization of the cell shape, such as differentiation and migration. It seems to affect intracellular transport of drugs and may participate in chemoresistance of small cell lung cancer (SCLC by sequestration), rather than mediating cellular uptake. The SLCO5/OATP5 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340962 [Multi-domain] Cd Length: 425 Bit Score: 46.58 E-value: 4.92e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 123 AGVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWS--AVTFSssfIPQqyfwLLVLSR 200
Cdd:cd17404   23 NSVITTIEKRYSLKSSESGLIVSSYEIGSLLTVVFVSYFGGRGHRPRWIAVGGVLIAlgSFLFS---LPH----FFILAQ 95

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 568973129 201 GLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGS 250
Cdd:cd17404   96 ILIGMGGTPIFTLGTTYLDDHVKKESSSLYLAIMYVMGALGPAAGFLLGG 145

MFS_GLUT_Class1_2_like

cd17357

Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ...

145-286

4.93e-05

Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 46.49 E-value: 4.93e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 145 SVFICSFMVAAPIFGYLGDRFNRKVIL---SCGIFFWSAVTFSSSFIPqqYFWLLVLSRGLVGIGEASYSTIAPTIIGDL 221
Cdd:cd17357   56 SIFFIGGAIGSFISAFLANRFGRKNGLlisNALLVVSSLLMFLSKSAK--SPELLIFGRFLVGIACGLSTGFVPMYLQEI 133

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568973129 222 FTKNTRTLMlSVFY-----FAIPLGSGLG--YITGSSVKqaagdWHWALrVSPVLGMITGTLILILVPATKR 286
Cdd:cd17357  134 SPSELRGAL-GSLTqigvtLGILLGQVFGlpSVLGTETL-----WPYLL-FFPGIPALLQLAALPFFPESPK 198

MFS_SVOPL

cd17442

Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) of the Major Facilitator Superfamily; ...

151-281

5.91e-05

Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) or SVOP-like protein is a transporter-like protein that shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. It belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341000 [Multi-domain] Cd Length: 375 Bit Score: 45.95 E-value: 5.91e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 151 FMVAAPIFGYLGDRFNRKVILScGIFFWSA-VTFSSSFIPqQYFWLLVLsRGLVGIGEASYSTiAPTIIGDLFTKNTRTL 229
Cdd:cd17442   49 YMVFSILLGLLADRYGRWKILL-LSFVWGAyFSLLTSFAP-SYIWFVFL-RCMVGCGVSGHSQ-GLIIKTEFLPTKYRGY 124

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 568973129 230 ML---SVFYFAiplGSGLGYITGSSVKQAAGdWHWALRVSPVLGmitgtLILILV 281
Cdd:cd17442  125 MLplsQIFWLA---GSLLIIGLASVVIPTLG-WRWLIRFASIPG-----IILIVV 170

MFS_MefA_like

cd06173

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...

140-431

6.04e-05

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 46.07 E-value: 6.04e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 140 AGLLQSVFICSFMVAAPIFGYLGDRFNRKVIL---SCGIFFWSAVTFSSSFIPQQYFWLLVLSRGLVGIGEASYSTIAPT 216
Cdd:cd06173   36 VGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLilaDLLRALLAAVLALLALLGSLSLWLLLVLAFLLGIASAFFGPARQA 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 217 IIGDLFTKNTRT----LMLSVFYFAIPLGSGLGyitgsSVKQAAGDWHWALRVSPVLGMITGTLILILVPATKRghadql 292
Cdd:cd06173  116 LLPELVPKEQLVranaLNSLATQLARIIGPALG-----GLLVALLGPGGAFAINALSFLLSALLLLFIRRPPPA------ 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 293 gGQLKARTSWLRDMKA----LIRNRSYVFSSLATSAVSFATGALGMWIPLYlhraqvvqktaetcnsppcgAKDSLIFGA 368
Cdd:cd06173  185 -APGESSSLLLRDLREglryLRRSPLLRLLLLALALFALLGGALTVLLPLL--------------------AKEVLGGGA 243

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568973129 369 ITcfTGFLGVVTGAGA---TRWC-RLRTQRADPLVCAVGMLGSAIFicLIFVAAKTSIVGAYICIFV 431
Cdd:cd06173  244 AG--YGLLLAAFGVGAllgALLLgRLSKRRRRGRLLLIGALLLGLA--LLVLGLSPSLWLLLAALFL 306

MFS_Azr1_MDR_like

cd17502

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...

108-261

6.49e-05

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 45.63 E-value: 6.49e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 108 LSLGNVLNYLDRYTVAGVLLDIQQHFGVKDRgAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFF------WSAV 181
Cdd:cd17502    1 LMLALFLAALDQTIVATALPTIVAEFGGLSL-VSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIfelgslLCGL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 182 TFSSsfipqqyfWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGdWHW 261
Cdd:cd17502   80 APNM--------TMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLS-WRW 150

MFS_TRI12_like

cd06179

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ...

153-297

7.63e-05

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 46.08 E-value: 7.63e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 153 VAAPIFGYLGDRFNRKVILSCGIFFW---SAVTFSSSFIPQqyfwlLVLSRGLVGIGeASYSTIAPTIIGDLFTKNTRTL 229
Cdd:cd06179   47 VLGPIVGRLSDLFGRRWFFIGGNLLGvvgSIVAGTAKSVNM-----LIGGQALIGIG-AGTQGLGAAVASELVPNKYRGL 120

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568973129 230 MLSVFYFAIPLGSGLG-YITGSSVKQAAGDWHWALRVSPVLGMITGTLILILV--PATKRGHADQLGGQLK 297
Cdd:cd06179  121 VQGVVNLVASPGSALGpLIAGALVEANAAGWRWIFYINAIFNALALILLFFFYhpPPRPQLHGSSTRQKLK 191

PRK11102

Bcr/CflA family multidrug efflux MFS transporter;

126-328

1.00e-04

Bcr/CflA family multidrug efflux MFS transporter;

Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 45.29 E-value: 1.00e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 126 LLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIP--QQYFWLlvlsRGLV 203
Cdd:PRK11102  14 LPVIAADFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQtiDQLIYM----RFLH 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 204 GIGEASYSTIAPTIIGDLFTKNTRTLMLS----VFYFAiPLgsgLGYITGSSVKQAAGdWHWALRVSPVLGMITGTLILI 279
Cdd:PRK11102  90 GLAAAAASVVINALMRDMFPKEEFSRMMSfvtlVMTIA-PL---LAPIIGGWLLVWFS-WHAIFWVLALAAILAAALVFF 164

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 568973129 280 LVPATkrgHADQLGGQLKARTSwLRDMKALIRNRSyVFSSLATSAVSFA 328
Cdd:PRK11102 165 FIPET---LPKERRQPFHLRTT-IRNFASLFRHKR-VLGYMLASGFSFA 208

MFS_SLCO4_OATP4

cd17403

Solute carrier organic anion transporter 4 family of the Major Facilitator Superfamily of ...

129-445

1.11e-04

Solute carrier organic anion transporter 4 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 4 (SLCO4) or Organic anion transporting polypeptide 4 (OATP4) family contains two families: OATP4A and OATP4C, each containing one mammalian member, OATP4A1 and OATP4C1, respectively. OATP4A1 (encoded by SLCO4A1), is ubiquitously expressed and mediates the Na(+)-independent transport of the thyroid hormones T3 (triiodo-L-thyronine), T4 (thyroxine) and rT3, and other organic anions such as estrone sulfate and taurocholate. OATP4C1 (encoded by SLCO4C1) is capable of transporting pharmacological substances such as digoxin, ouabain, thyroxine, methotrexate, cAMP, and uremic toxins, which accumulate in patients with chronic kidney diseases (CKDs). The SLCO4/OATP4 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340961 [Multi-domain] Cd Length: 420 Bit Score: 45.32 E-value: 1.11e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 129 IQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWS--AVTFSssfIPQqyFWLLVLSRGLVGIG 206
Cdd:cd17403   30 IEKRFGLTSTQTGLIASSYDIASVLLLLFVSYFGGRGHKPRWLGIGAFIMGigSLVFA---LPH--FTVFILAQLLHGAG 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 207 EASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGDWHwalrvspvlgmiTGTLILILVPATKR 286
Cdd:cd17403  105 ATPLYTLGVTYLDENVSTKMSPLYIGIFYAMAILGPAIGYVLGGFLLNLYTDID------------QVDSELGLTPDDPR 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 287 --GhADQLGGQLKARTSWLRDMKALIRNRSYVFSSLATSAVSFATGALGMWIPLYLHraqvvqktaETCNSPPCGAkdSL 364
Cdd:cd17403  173 wvG-AWWLGFLISGALALIIAFPLLGFPPTFMFLNLAGASEGMLLAGFATFLPKLIE---------SQFSLSASLA--AL 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 365 IFGAITCFTGFLGVVTGAGATRWCRLRTQRADPLVCAVGMLGSAIFICLIFVAAKTSIVGayICIFVGETLLFSNWAITA 444
Cdd:cd17403  241 LVGVVVVPGGILGTFLGGLIVKKLKLKCKGILKFCIVCSIVAFLFSFILLIYCPNAPFAG--VTVPYGNSPLEGTSNLTS 318


                 .
gi 568973129 445 D 445
Cdd:cd17403  319 T 319

MFS_HXT

cd17356

Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ...

105-286

2.43e-04

Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340914 [Multi-domain] Cd Length: 403 Bit Score: 44.16 E-value: 2.43e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 105 AAILSLGNVLNYLDRYTVAGVL--LDIQQHFGVKDRGAGLLQSV--FICSFMVAAPIFG-----YLGDRFNRKVILSCGI 175
Cdd:cd17356    3 CAFVSLGGFLFGYDTGSISGILnmKSFQKYFADNTGTYYPSSSRqgLIVSIVNLGSFFGalissFLSDRIGRKKSIQIGC 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 176 FFWS-AVTFSSSFIPQQyfWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQ 254
Cdd:cd17356   83 VIYIiGAIIQVAAIGKW--YQLIVGRIIAGLGVGFASVLVPVYQSEVAPKHIRGTLVSLYQLAITIGILVAYCINYGTHK 160

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 568973129 255 AAGDWHWalRVSPVLGMITGTLILI---LVPATKR 286
Cdd:cd17356  161 LDGSAQW--RIPLGLQIVWGLLLLIgmfFLPESPR 193

TRI12

pfam06609

Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific ...

103-279

2.76e-04

Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific trichothecene efflux pump proteins. Many of the genes involved in trichothecene toxin biosynthesis in Fusarium sporotrichioides are present within a gene cluster.It has been suggested that TRI12 may play a role in F. sporotrichioides self-protection against trichothecenes.

Pssm-ID: 115279 [Multi-domain] Cd Length: 598 Bit Score: 44.27 E-value: 2.76e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129  103 AAAAILSLGNVLNYLDRYTVAGVLLDIQQHFGvKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRK--VILSCGIFFWSA 180
Cdd:pfam06609  44 ASFAAFSLNVCATYFVLQASASALPNILQDIG-QSENQGLFSTLWTMGQAVSILMMGRLTDRFGRRpfVIATHIIGLVGA 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129  181 VTFSSSfipqQYFWLLVLSRGLVGIGeASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVkQAAGDWH 260
Cdd:pfam06609 123 IVGCTA----NKFNTLLAAMTLLGVA-AGPAGASPLFIGELMSNKTKFLGLLIVSAPTIAMNGAGPYFGQRL-AIQGNWR 196

                         170
                  ....*....|....*....
gi 568973129  261 WALRVSPVLGMITGTLILI 279
Cdd:pfam06609 197 WIFYIYIIMSAIAVLLIII 215

MFS_PhT

cd17364

Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ...

140-252

4.57e-04

Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340922 [Multi-domain] Cd Length: 389 Bit Score: 43.42 E-value: 4.57e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 140 AGLLQSVFICSFMVAAPIFGYLGDRFNRK-------VILSCGIFfwsAVTFSSSFIPQQYFWLLVLSRGLVGIGEASYST 212
Cdd:cd17364   41 SGLVNAAALVGTIIGQLFFGFLGDRFGRKrvygvelIIMIIGTI---LSALSPGSTPLGVMGWLIFFRFLLGIGIGGDYP 117

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 568973129 213 IAPTIIGDLFTKNTR-TLMLSVFYFaiplgSGLGYITGSSV 252
Cdd:cd17364  118 LSATIMSEYANKKRRgALIAAVFAM-----QGFGILAGAIV 153

PTR2

pfam00854

POT family; The POT (proton-dependent oligopeptide transport) family all appear to be proton ...

175-280

5.85e-04

POT family; The POT (proton-dependent oligopeptide transport) family all appear to be proton dependent transporters.

Pssm-ID: 425909 [Multi-domain] Cd Length: 392 Bit Score: 43.08 E-value: 5.85e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129  175 IFFWSAVtfsSSFIPQQYFWLLVLSRGLVGIGeasYSTIAPTI---IGDLFTKNT---RTLMLSVFYFAIPLGSGLGYIT 248
Cdd:pfam00854  17 LLALSAI---PSLRPPVHVALFFIGLALIALG---TGGIKPNVssfGGDQFEETDprrRSRFFSIFYFSINAGSLISTII 90

                          90       100       110
                  ....*....|....*....|....*....|..
gi 568973129  249 GSSVKQAAGdWHWALRVsPVLGMITGTLILIL 280
Cdd:pfam00854  91 TPYLQQNYG-YPLGFGL-PAVGMIIALLVFLL 120

MFS_MFSD9

cd17390

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ...

140-249

7.43e-04

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 42.60 E-value: 7.43e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 140 AGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFF----WSAVTFSSSFIpqqyfwLLVLSRGLVGIGEASySTIAP 215
Cdd:cd17390   33 IGLIGSVYGALQLFSSPLVGSWSDVVGRRPVLLICLLLtalgYVLLGFSTSLA------LLFLSRIPLGIFKHT-QSLCK 105

                         90       100       110
                 ....*....|....*....|....*....|....
gi 568973129 216 TIIGDLFTKNTRTLMLSVFYFAiplgSGLGYITG 249
Cdd:cd17390  106 AYLSDLVSEQERSRVLGRFNAA----SSLGFILG 135

MFS_OFA_like

cd17353

Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ...

122-280

9.43e-04

Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 42.21 E-value: 9.43e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 122 VAGVLLDIQQHFGVKDRGAGLLqSVFICSFMVAA--PIFGYLGDRFNRK----VILSCGIFFWSAVTFSSSfipqqYFWL 195
Cdd:cd17353  232 LIGQAKPIGQEFAGLDAGIAAL-AVSILSIFNGGgrPFWGWLSDKIGRKntlsIAFLIQGVAMFLLPFIGS-----VAVL 305

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 196 LVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQaAGDWHWALRVSPVLGMITGT 275
Cdd:cd17353  306 FVLGVALIGFCYGGGFALFPALTADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAAYVLY-TGGYNAAFIIAAALSLVALA 384


                 ....*
gi 568973129 276 LILIL 280
Cdd:cd17353  385 LALLL 389

MFS_GlpT

cd17345

Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ...

141-485

1.62e-03

Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 41.46 E-value: 1.62e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 141 GLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIP--QQYFWLLVLSRGLVGI-----GEASYSTI 213
Cdd:cd17345   41 GLIGSALSIAYGLSKFVMGNLSDRSNPKRFLAIGLILSAIINILIGFVPsaTSSVGLMFILLFLNGWfqgmgWPPSGRTM 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 214 AptiigDLFTKNTRTLMLSVFYFAIPLGSGL--GYITGSSVKQAAGDWHWALRVSPVLGMITGTLILILVPAT------- 284
Cdd:cd17345  121 V-----HWFSKKERGTWTSIWNISHNVGGGLvgPLAGLGLAIFGDGWWRGAFIFPAIIAIIVAVIVLFLGKDTpeseglp 195

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 285 -------KRGHADQLGGQLKARTSWLRDMKALIRNRSYVFSSLATSAVSFATGALGMWIPLYLhrAQVVQKTAETcnspp 357
Cdd:cd17345  196 pieeykgDYPEEADGEEEEQELSAWEIFVKYVLKNKLLWYIAIANVFVYLVRYGILDWAPTYL--SEVKGFSKAQ----- 268

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 358 cGAKDSLIF--GAI--TCFTGFLGVVTGAGatrwcrlrtQRAdpLVCAVGMLGsaIFICLIFVAAKTSIVGAYICIFVGE 433
Cdd:cd17345  269 -AMWAFSLFewAAIpgTLLAGWLSDKLFKG---------RRA--PTGIIFMIL--VIVALIVYWLAPNVLVDLIALIALG 334

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|..
gi 568973129 434 TLLFSNWAITADILMYVVIPTRRATAVALQSFTSHLLGDAGSPYLIGFISDL 485
Cdd:cd17345  335 FLIYGPVMLIGLQALELVPKKAAGTAAGLTGLFGYLGGSVLATALIGIIVDH 386

MFS_MFSD10

cd17389

Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ...

141-227

2.20e-03

Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340947 [Multi-domain] Cd Length: 391 Bit Score: 41.11 E-value: 2.20e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 141 GLLQSVFicSFM--VAAPIFGYLGDRFNRK-VILSC--GIFFWSAV-TFSSSFIpqqyfwLLVLSRGLVGIGEASYStIA 214
Cdd:cd17389   67 GLIGSLF--SLLqfLSSPITGAASDVYGRKpVLLLTmiGLAISYALwAVSRSFT------IFLLSRIVGGISKGNVS-LS 137

                         90
                 ....*....|...
gi 568973129 215 PTIIGDLFTKNTR 227
Cdd:cd17389  138 TAIVADVTSPKKR 150

PRK12307

MFS transporter;

110-442

2.44e-03

MFS transporter;

Pssm-ID: 237051 [Multi-domain] Cd Length: 426 Bit Score: 41.07 E-value: 2.44e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 110 LGNVLNYLDRYTVAGVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIP 189
Cdd:PRK12307  25 LGYVFDGFDFMLIFYIMYLIKADLGLTDMEGAFLATAAFIGRPFGGALFGLLADKFGRKPLMMWSIVAYSVGTGLSGLAS 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 190 QQYfwLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTlMLSVFYFAiplGSGLGYITGSS-VKQAAGDWHWalRVSPV 268
Cdd:PRK12307 105 GVI--MLTLSRFIVGMGMAGEYACASTYAVESWPKHLKS-KASAFLVS---GFGIGNIIAAYfMPSFAEAYGW--RAAFF 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 269 LGMITGTLILIL---VPATKRGHADQLGGQLK----ARTSWLRDMKALIrNRSYVFSSLATSAVSF----ATGALGMWIP 337
Cdd:PRK12307 177 VGLLPVLLVIYIrarAPESKEWEEAKLSGKGKhsqsAWSVFSLSMKGLF-NRAQFPLTLCVFIVLFsifgANWPIFGLLP 255

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 338 LYLHRAQVvqktaetcnsppcgakDSLIFGAITCFTGFlGVVTGAGATRWCRLRTQRADPLVcaVGMLGSAIFIC-LIFV 416
Cdd:PRK12307 256 TYLAGEGF----------------DTGVVSNLMTAAAF-GTVLGNIVWGLCADRIGLKKTFS--IGLLMSFLFIFpLFRI 316

                        330       340
                 ....*....|....*....|....*..
gi 568973129 417 AAK-TSIVGAyiCIFvgeTLLFSNWAI 442
Cdd:PRK12307 317 PQDnYLLLGA--CLF---GLMATNVGV 338

MFS_GLUT10_12_Class3_like

cd17362

Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ...

141-285

2.86e-03

Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340920 [Multi-domain] Cd Length: 389 Bit Score: 40.80 E-value: 2.86e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 141 GLLQSVFICSFMVAAPIFGYLGDRFNRK--VILSCGIFFWSAVTFSssfIPQQYFWLLVlSRGLVGIGEASYSTIAPTII 218
Cdd:cd17362   42 GLVVSGSLLGALLGSLVAGALIDRLGRRkeLILAALLYLVGSLVTG---LAPSYPVLLV-GRLIYGVGIGLAMHAAPVYI 117

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568973129 219 GDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGDWHWALRVSPVLGMITGTLILILVPATK 285
Cdd:cd17362  118 AETSPSHIRGLLVSLKELFIVLGILLGYVSGYAFADVVGGWRYMYGLAAPPALLLGIGMWFLPPSPR 184

MFS_SLC22A16_CT2

cd17375

Solute carrier family 22 member 16 (also called Carnitine transporter 2) of the Major ...

140-203

3.21e-03

Solute carrier family 22 member 16 (also called Carnitine transporter 2) of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 16 (SLC22A16) is also called carnitine transporter 2 (CT2), fly-like putative transporter 2 (FLIPT2), organic cation transporter OKB1, or organic cation/carnitine transporter 6 (OCT6). It is a partially sodium-ion dependent high affinity carnitine transporter. It also transports organic cations such as tetraethylammonium (TEA) and doxorubicin. It is one of several organic cation transporters (OCTs) that falls into the SLC22 (solute carrier 22) family. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. SLC22A16 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340933 [Multi-domain] Cd Length: 341 Bit Score: 40.50 E-value: 3.21e-03

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568973129 140 AGLLQSVFICSFMVAAPIFGYLGDRFNRKVIL----SCGIFFWSAVTFSS---SFIPQQYFWLLVLSRGLV 203
Cdd:cd17375   37 AKLIQPIFMLGVLLGAVIFGDIADRIGRRPVLwftsTGQFVFGIAVAFTFdyySFVIVRFLLAMVSSGYLV 107

MFS_SLCO2B_OATP2B

cd17460

Solute carrier organic anion transporter 2B subfamily of the Major Facilitator Superfamily of ...

129-252

5.66e-03

Solute carrier organic anion transporter 2B subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 2B (SLCO2B), also called Organic anion-transporting polypeptide 2B (OATP2B), subfamily has one mammalian member, OATP2B1 (encoded by SLCO2B1). It mediates the Na(+)-independent transport of various organic anions such as taurocholate, the prostaglandins PGD2, PGE1, PGE2, leukotriene C4, thromboxane B2 and iloprost. It also mediates the transport of endogenous sex steroid conjugates such as dehydroepiandrosterone sulfate (DHEAS). SLCO2B1 variations result in differential expression and uptake of DHEAS, which impacts subsequent resistance to androgen-deprivation therapy (ADT), the primary treatment of metastatic prostate cancer. The SLCO2B/OATP2B subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341018 [Multi-domain] Cd Length: 479 Bit Score: 39.75 E-value: 5.66e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 129 IQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSS---FIPQQY-FWLLVLSRGLVG 204
Cdd:cd17460   29 IEKRFGLSSQTSGLLASFNEVGNTVLIVFVSYFGSRVHRPRFIGCGAILVSLAGFLMAlphFISEPYeYGILFLGQLLLG 108

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 568973129 205 IGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSV 252
Cdd:cd17460  109 IGGVPIQPFGISYIDDFASESNSPLYLGILFAVTVLGPGFGFMLGSAM 156

synapt_SV2

TIGR01299

synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ...

98-208

5.71e-03

synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.

Pssm-ID: 130366 [Multi-domain] Cd Length: 742 Bit Score: 39.96 E-value: 5.71e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129   98 GRGRGAAAAILSLGNVL--NYLDRYTVAGVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGI 175
Cdd:TIGR01299 160 GHGRFQWALFFVLGLALmaDGVEVFVVGFVLPSAEKDLCIPDSGKGMLGLIVYLGMMVGAFFWGGLADKLGRKQCLLICL 239

                          90       100       110
                  ....*....|....*....|....*....|...
gi 568973129  176 FFWSAVTFSSSFIPQQYFWLLVLSRGLVGIGEA 208
Cdd:TIGR01299 240 SVNGFFAFFSSFVQGYGFFLFCRLLSGFGIGGA 272

MFS_SLC37A3

cd17342

Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute ...

141-252

6.80e-03

Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 3 (SLC37A3) is also called sugar phosphate exchanger 3 (SPX3), and is one of four SLC37 family proteins in vertebrates. It's function and activity is unknown. The best characterized SLC37 family member is SLC37A4, also called the glucose-6-phosphate transporter (G6PT), a phosphate (Pi)-linked G6P antiporter. SLC37A3 is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340900 [Multi-domain] Cd Length: 399 Bit Score: 39.60 E-value: 6.80e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 141 GLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIPQqyfWLLVLSRGLVGIGEASY----STIAP- 215
Cdd:cd17342   66 GVLDTIFLFSYAIGLFISGWLGDRLNLRLVLAFGMCSSAITVFLFGVLTE---WLHFYNKYLYCILWVLNgllqSTGWPc 142

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 568973129 216 --TIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSV 252
Cdd:cd17342  143 vvAIMGNWFGKSSRGFVLGLWSACASVGNIIGALLASSV 181

MFS_YcxA_like

cd17355

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...

119-485

6.93e-03

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 39.56 E-value: 6.93e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 119 RYTVAGVLLDIQQHFGVkDRGA-GLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIPQqyFWLLV 197
Cdd:cd17355   19 RYYFGVFIIPIIAEFGW-SRAViSLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATS--LWQLY 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 198 LSRGLVGIGEAS--YSTIAPTIIGDLFTKNtRTLMLSVfyfaIPLGSGLGYITGSSVKQAAGD---WHWALRVSPVLGMI 272
Cdd:cd17355   96 LLWGLLGGGGAGtlAAVAFATVAAWWFERR-RGLALGI----LTAGGGLGSLVFLPLGAALIEafgWRTALLVLALLALL 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 273 TgTLILILVPATKRGHADQLGGQLKARTSWLRDMKALIRNRSYVFSSLATSAVSFATGALGMWIPLYLhraqvvqktaET 352
Cdd:cd17355  171 V-LVPVLLLLRRRPADLALRAYDDASPASPGSTLKEALRSASFWLLALAFFLCGFAVVGLIVHLVPYL----------AD 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 353 CNSPPCGAkdSLIFGAITCFTGFLGVVTGAGATRWCRlrtqradPLVCAVGMLGSAIFICLIFVAAKTSIVGAYICIFVG 432
Cdd:cd17355  240 RGISPAAA--AVALALIGLFNIVGRLLSGWLGDRYSP-------RRLLAASYALRALGLALLLLLPFPPLALLLFAALFG 310

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 568973129 433 ETllfsnWAITADILMYVV---IPTRRATAVALQSFTSHLLGDAGSPYLIGFISDL 485
Cdd:cd17355  311 LG-----WGATVPLTAALAaryFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDR 361

MFS_SLC22A6_OAT1_like

cd17446

Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar ...

142-239

8.36e-03

Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar transporters of the Major Facilitator Superfamily; This subfamily includes solute carrier family 22 member 6 (SLC22A6, also called organic anion transporter 1 or OAT1 or para-aminohippurate (PAH) transporter), SLC22A8 (or OAT3), and SLC22A20 (or OAT6). OAT1 and OAT3 are involved in the renal elimination of endogenous and exogenous organic anions (OAs). They function as OA exchangers, coupling the uptake of OAs against an electrochemical gradient with the efflux of intracellular dicarboxylates. SLC22A20 is an OA transporter that mediates the uptake of estrone sulfate. The OAT1-like subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341004 [Multi-domain] Cd Length: 339 Bit Score: 38.94 E-value: 8.36e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 142 LLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFW----SAVTFSSSFIPQQYFWLLVlSRGLVGIGEASYS------ 211
Cdd:cd17446   37 LAQSIYMAGVLVGAIVFGGLSDRFGRRPLLIWSYLQMavsgTCAAFSPSFPIYCVFRFLT-GMALSGIVLNSVSlnvewm 115

                         90       100       110
                 ....*....|....*....|....*....|...
gi 568973129 212 -----TIAPTIIGDLFTknTRTLMLSVFYFAIP 239
Cdd:cd17446  116 ptrvrAVVGTLLGYCYT--LGQLILAGVAYAIR 146

MFS_SLC22A7_OAT2

cd17447

Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major ...

142-273

9.37e-03

Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 7 (SLC22A7), also called organic anion transporter 2 (OAT2) mediates sodium-independent transport of a variety of organic anions including prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate, allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha-ketoglutarate. It also plays a role in renal uric acid uptake from blood as a first step of tubular secretion. OAT2 belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS)of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341005 [Multi-domain] Cd Length: 341 Bit Score: 38.94 E-value: 9.37e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973129 142 LLQSVFICSFMVAAPIFGYLGDRFNRKVILS----CGIFFWSAVTFSSSFIpqqyfwLLVLSRGLVGIGEASYSTIAPTI 217
Cdd:cd17447   39 ATATFFFAGVTMGAVAFGYLSDRFGRKRMLLvayvLSLVFGLASAFSVSYV------MFAITRTLTGFALTGFSIISMVL 112

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 568973129 218 IGDLFTKNTRTlmlsVFYFAIPLGSGLGYITGSSVKQAAGDWHWALRV--SP-VLGMIT 273
Cdd:cd17447  113 CVEWVDIEHRT----VAGVLISLFWTVGNMLLALVAYLIRDWRWLILAvtLPcAPGIIT 167

Blast search parameters

Data Source:	Precalculated data, version = cdd.v.3.21
Preset Options:	Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01