|
Name |
Accession |
Description |
Interval |
E-value |
| Ten_N |
pfam06484 |
Teneurin Intracellular Region; This family is found in the intracellular N-terminal region of ... |
10-374 |
0e+00 |
|
Teneurin Intracellular Region; This family is found in the intracellular N-terminal region of the Teneurin family of proteins. These proteins are 'pair-rule' genes and are involved in tissue patterning, specifically probably neural patterning. The intracellular domain is cleaved in response to homophilic interaction of the extracellular domain, and translocates to the nucleus. Here it probably carries out to some transcriptional regulatory activity. The length of this region and the conservation suggests that there may be two structural domains here (personal obs:C Yeats).
Pssm-ID: 461932 [Multi-domain] Cd Length: 367 Bit Score: 646.26 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973899 10 SLTRGRCGKECRYTSSSLDSEDCRVPTQKSYSSSETLKAYDHDSRMHYGNRVTDLVHRESDEFSRQGTNFTLAELGICEP 89
Cdd:pfam06484 1 SLTKRRRDKERRYTSSSADSEECRVPTQKSYSSSETLKAFDHDSRMLYGNRVKDMVHKEADEFSRQGQNFSLRELGICEP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973899 90 SP-HRSGYCSDMGILHQGYSLSTGSDADSDTEGGMSPEHAIRLWGRGIKSRRSSGLSSRENSALTLTDSDNENKSDDDNG 168
Cdd:pfam06484 81 SPrHGLAYCTEMGLPHRGYSISTGSDADTETDGPMSPEHAVRLWGRGTKSGRSSCLSSRSNSALTLTDTEHENKSDNENG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973899 169 RPIPPTSSSSLLPsaqlpSSHNPPP---VSCQMPLLDSNTSHQIMDTNPDEEFSPNSYLLRACSGPQQASSSGPPNHHSQ 245
Cdd:pfam06484 161 PPIPPSSSSSSPV-----EQHSPPPpslNENQRPLLGNNASHPILDSDPDEEFSPNSYLVRTGSGPQSAPSEQPPNFQNH 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973899 246 STLRPPLPP-PHNHT-LSHHHSSANSLNRNSLTNRRSQIHAP-APAPNDLATTPESVQLQDSWVLNSNVPLETRHFLFKT 322
Cdd:pfam06484 236 SRLRTPPPPlPPPHKqNQHHHPSINSLNRSSLTNRRNPSPAPtASLPAELQSTQESVQLQDSWVLNSNVPLETRHFLFKT 315
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 568973899 323 SSGSTPLFSSSSPGYPLTSGTVYTPPPRLLPRNTFSRKAFKLKKPSKYCSWK 374
Cdd:pfam06484 316 GTGTTPLFCTASPGYPLTSGTVYSPPPRPLPRNTFSRPAFKLKKPYKYCSWK 367
|
|
| NHL_like_1 |
cd14953 |
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ... |
1231-1554 |
1.04e-46 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271323 [Multi-domain] Cd Length: 323 Bit Score: 171.94 E-value: 1.04e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973899 1231 PVALAVGIDGSLFVGDF--NYIRRIFPSRNVTSIL---------------ELrNSPghkYYLAVDPvTGSLYVSDTNSRR 1293
Cdd:cd14953 25 PSGVAVDAAGNLYVADRgnHRIRKITPDGVVTTVAgtgtagfadgggaaaQF-NTP---SGVAVDA-AGNLYVADTGNHR 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973899 1294 IYRVkslsgakDLAGNSEVVAGTGEqclpfdeARCGDGGKAVDATLMSPRGIAVDKNGLMYFVDAT--MIRKVDQNGIIS 1371
Cdd:cd14953 100 IRKI-------TPDGVVSTLAGTGT-------AGFSDDGGATAAQFNYPTGVAVDAAGNLYVADTGnhRIRKITPDGVVT 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973899 1372 TLLGsndlTAVRPLSCDSSMDVAQVRleWPTDLAVNPMDNsLYVLE--NNVILRITENHQVSIIAGRPmhcqvpGIDYSL 1449
Cdd:cd14953 166 TVAG----TGGAGYAGDGPATAAQFN--NPTGVAVDAAGN-LYVADrgNHRIRKITPDGVVTTVAGTG------TAGFSG 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973899 1450 SKLAIHSALESASAIAISHTGVLYITETDEkkiNRLRQVTTNGEICLLAGAASDcdckndvncicYSGDDAYATDAILNS 1529
Cdd:cd14953 233 DGGATAAQLNNPTGVAVDAAGNLYVADSGN---HRIRKITPAGVVTTVAGGGAG-----------FSGDGGPATSAQFNN 298
|
330 340
....*....|....*....|....*
gi 568973899 1530 PSSLAVAPDGTIYIADLGNIRIRAV 1554
Cdd:cd14953 299 PTGVAVDAAGNLYVADTGNNRIRKI 323
|
|
| Tox-GHH |
pfam15636 |
GHH signature containing HNH/Endo VII superfamily nuclease toxin; A predicted toxin of the HNH ... |
2674-2751 |
4.18e-37 |
|
GHH signature containing HNH/Endo VII superfamily nuclease toxin; A predicted toxin of the HNH/Endonuclease VII fold present in bacterial polymorphic toxin systems with a characteriztic sG[HQ]H signature motif. In bacterial polymorphic toxin systems, the toxin is exported by the type 2, type 6, type 7 or TcdB/TcaC-type secretion system. The metazoan teneurin proteins possess an inactive of this domain at their C-terminus.
Pssm-ID: 464783 Cd Length: 78 Bit Score: 135.05 E-value: 4.18e-37
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568973899 2674 EEKARVLDQARQRALGTAWAKEQQKARDGREGSRLWTEGEKQQLLSTGRVQGYEGYYVLPVEQYPELADSSSNIQFLR 2751
Cdd:pfam15636 1 EERKRLLEHAKKRAVREAWHRERQLLRNGLPGSRDWTDEEKEELLSTGSVPGYDGEYIHPVEQYPELADDPSNIRFRK 78
|
|
| RhsA |
COG3209 |
Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction ... |
1515-2452 |
2.12e-31 |
|
Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only];
Pssm-ID: 442442 [Multi-domain] Cd Length: 1103 Bit Score: 135.65 E-value: 2.12e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973899 1515 YSGDDAYATDAILNSPSSLAVAPDGTIYIADLGNIRIRAVSKNKPVLNAFNQYEAASP---GEQELYVFNADGIHQYTVS 1591
Cdd:COG3209 105 LTGLAAATASAGRLVSTGAGAGGTVTAATGGTLGATAGSATTGSTDGGRGGVAVTGLAgggASAYGLTLGGAAAGPATGV 184
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973899 1592 LVTGEYLYNFTYSADNDVTELIDNNGNSLKIRRDSSGMPRHLLMPDNQIITLTVGTNGGLKAVSTQNLELGLMTYDGNTG 1671
Cdd:COG3209 185 GTGAVTLATGLAGSALLALGSGAILGGLAGAYSGSATTATGTALGTPASVAATVTGSATGAAGAGAAVATAATTLGGTTG 264
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973899 1672 LLATKSDETGWTTFYDYDHEGRLTNVTRPTGVVTSLHREMEKSITIDIENSNRDDDVTVITNLSSVEASYTVVQDQVRNS 1751
Cdd:COG3209 265 AGTGASGAGLDASTGTGGAGGSNAAATAGGLGGAGLGSGGAGGGGTAGGTTTAAGTTGTAAVSGAADAGTTTTTGTGTGG 344
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973899 1752 YQLCNNGTLRVMYANGMAVSFHSEPHVLAGTITPTIGRCNISLPMENGLNSIEWRLRKEQIKGKVTIFGRKLRVHGRNLL 1831
Cdd:COG3209 345 TTTTVGGGGSLTLGGYGAAGGLTTSVGAGGGGSTSGSTTTVGGGGTATGSGGGSSTTGVGAGTTTTSTTGGDGGPATAAG 424
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973899 1832 SIDYDRNIRTEKIYDDHRKFTLRIIYDQVGRPFLWLPSSGLAAVNVSYFFNGRLAGLQRGAMSERTDIDKQGRIVSRMFA 1911
Cdd:COG3209 425 ALTAGGTATGTGTGGGGTTAGTDATTTTGGAGASGTLTTTGGAATGATTGGGTEAGTGGGTLTSGSAGATTLGTDTTLDD 504
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973899 1912 DGKVWSYSYLDKSMVLLLQSQRQYIF--------EYDSSDRLHAVTMPSVARHSMSTHTSIGYIRNIYNPPESNASVIFD 1983
Cdd:COG3209 505 TLGGTTTTTAGARGLVVTTGTTLTLGttttatlsATDATGTGDTTTTGTVGTGTSTGTGGTGTVTTTGDGTGGASTTTGT 584
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973899 1984 YSDDGRILKTSFLGTGRQVFYKYGKLSKLSEIVYDSTAVTFGYDETTGVLKMVNLQSGGFSCTIRYRKVGPLVDKQIYRF 2063
Cdd:COG3209 585 TGGTATTTTVTTTTTTSTAGTTTTTTSGYTRAGLTLTLGTGTASGLERATASTGSTTGGTTGTGVTTTGTTTTRATGTTG 664
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973899 2064 SEEGMINARFDYTYHDNSFRIASikpVISETPLPVDLYRYDEISGKVEHFGKFGVIYYDINQIITTAVMTLSKHFDTHGR 2143
Cdd:COG3209 665 TGTGVTAGLTTLATGGTTVGGGT---GTTSTATTGATTGGTETGTTVTTLAGGTTTRLGTTTTGGGGGTTTDGTGTGGTT 741
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973899 2144 IKEVQYEMF-RSLMYWMTVQYDSMGRVIKRELKLGPYANTTKYTYDYDGDGQLQSVAVNDRPTWRYSYDLNGNLH----- 2217
Cdd:COG3209 742 GTLTTTSTTtTTTAGALTYTYDALGRLTSETTPGGVTQGTYTTRYTYDALGRLTSVTYPDGETVTYTYDALGRLTsvitv 821
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973899 2218 LLNPGNSARLMPLRYDLRDRITRLGDVQykidDDGYLCQRgsdiFEYNSKGLLTRAynKASGWSVQYRYDGVGRRASyKT 2297
Cdd:COG3209 822 GSGGGTDLQDRTYTYDAAGNITSITDAL----RAGTLTQT----YTYDALGRLTSA--TDPGTTESYTYDANGNLTS-RT 890
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973899 2298 NLGHHlQYFYSDLHNPTRITHvynhSNSEITSLYYDLQGHlfamesssgeeyyvaSDNTGTPLAVFSINGLMIKQLQYTA 2377
Cdd:COG3209 891 DGGTT-TYTYDALGRLVSVTK----PDGTTTTYTYDALGH---------------TDHLGSVRALTDASGQVVWRYDYDP 950
|
890 900 910 920 930 940 950
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568973899 2378 YGEIYYDSNPDFQMVIGFHGGLYDPLTKLVHFTQRDYDVLAGRWTSPDytmwrNVGKEPAPfNLYMFKNNNPLSN 2452
Cdd:COG3209 951 FGNLLAETSGAAANPLRFTGQEYDAETGLYYNGARYYDPALGRFLSPD-----PIGLAGGL-NLYAYVGNNPVNY 1019
|
|
| Vgb |
COG4257 |
Streptogramin lyase [Defense mechanisms]; |
1231-1554 |
5.91e-13 |
|
Streptogramin lyase [Defense mechanisms];
Pssm-ID: 443399 [Multi-domain] Cd Length: 270 Bit Score: 71.59 E-value: 5.91e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973899 1231 PVALAVGIDGSLFVGDF--NYIRRIFP-SRNVTSILELRNSPGHKyyLAVDPvTGSLYVSDTNSRRIYRVkslsGAKDla 1307
Cdd:COG4257 19 PRDVAVDPDGAVWFTDQggGRIGRLDPaTGEFTEYPLGGGSGPHG--IAVDP-DGNLWFTDNGNNRIGRI----DPKT-- 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973899 1308 GNSEVVAGTGEQCLPFdearcgdggkavdatlmsprGIAVDKNGLMYFVDAT--MIRKVD-QNGIISTLlgsndltavrP 1384
Cdd:COG4257 90 GEITTFALPGGGSNPH--------------------GIAFDPDGNLWFTDQGgnRIGRLDpATGEVTEF----------P 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973899 1385 LSCDSSMdvaqvrlewPTDLAVNPmDNSLYV--LENNVILRI-TENHQVSIIAGrpmhcqvpgidyslsklaiHSALESA 1461
Cdd:COG4257 140 LPTGGAG---------PYGIAVDP-DGNLWVtdFGANAIGRIdPDTGTLTEYAL-------------------PTPGAGP 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973899 1462 SAIAISHTGVLYITETDEKKINRLRqvTTNGEIcllagaasdcdckndvncicysgdDAYATDAILNSPSSLAVAPDGTI 1541
Cdd:COG4257 191 RGLAVDPDGNLWVADTGSGRIGRFD--PKTGTV------------------------TEYPLPGGGARPYGVAVDGDGRV 244
|
330
....*....|...
gi 568973899 1542 YIADLGNIRIRAV 1554
Cdd:COG4257 245 WFAESGANRIVRF 257
|
|
| Rhs_assc_core |
TIGR03696 |
RHS repeat-associated core domain; This model represents a conserved unique core sequence ... |
2375-2452 |
7.51e-10 |
|
RHS repeat-associated core domain; This model represents a conserved unique core sequence shared by large numbers of proteins. It is occasional in the Archaea Methanosarcina barkeri) but common in bacteria and eukaryotes. Most fall into two large classes. One class consists of long proteins in which two classes of repeats are abundant: an FG-GAP repeat (pfam01839) class, and an RHS repeat (pfam05593) or YD repeat (TIGR01643). This class includes secreted bacterial insecticidal toxins and intercellular signalling proteins such as the teneurins in animals. The other class consists of uncharacterized proteins shorter than 400 amino acids, where this core domain of about 75 amino acids tends to occur in the N-terminal half. Over twenty such proteins are found in Pseudomonas putida alone; little sequence similarity or repeat structure is found among these proteins outside the region modeled by this domain.
Pssm-ID: 274730 [Multi-domain] Cd Length: 77 Bit Score: 57.51 E-value: 7.51e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973899 2375 YTAYGEIYYDSNPDFQmVIGFHGGLYDPLTKLVHFTQRDYDVLAGRWTSPDytmwrnvgkePA----PFNLYMFKNNNPL 2450
Cdd:TIGR03696 1 YDPYGEVLSESGAAPN-PLRFTGQYYDAETGLYYNGARYYDPELGRFLSPD----------PIglggGLNLYAYVGNNPV 69
|
..
gi 568973899 2451 SN 2452
Cdd:TIGR03696 70 NW 71
|
|
| acid_disulf_rpt |
NF033662 |
acidic double-disulfide repeat; The acidic double-disulfide repeat is an Asp-rich repeat with ... |
834-864 |
4.11e-08 |
|
acidic double-disulfide repeat; The acidic double-disulfide repeat is an Asp-rich repeat with four nearly invariant Cys residues in a repeat length of about 35 amino acids.
Pssm-ID: 411265 [Multi-domain] Cd Length: 32 Bit Score: 50.98 E-value: 4.11e-08
10 20 30
....*....|....*....|....*....|.
gi 568973899 834 AMETSCADNKDNEGDGLVDCLDPDCCLQSAC 864
Cdd:NF033662 2 ATDTTCSDGIDNDGDGLTDCADPDCAGNPVC 32
|
|
| PLN02919 |
PLN02919 |
haloacid dehalogenase-like hydrolase family protein |
1256-1552 |
2.40e-07 |
|
haloacid dehalogenase-like hydrolase family protein
Pssm-ID: 215497 [Multi-domain] Cd Length: 1057 Bit Score: 56.78 E-value: 2.40e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973899 1256 SRNVTSILELrnsPGHkyyLAVDPVTGSLYVSDTNSRRIYrvkslsgAKDLAGNSEV-VAGTGEQCL---PFDearcgdg 1331
Cdd:PLN02919 560 PRLLTSPLKF---PGK---LAIDLLNNRLFISDSNHNRIV-------VTDLDGNFIVqIGSTGEEGLrdgSFE------- 619
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973899 1332 gkavDATLMSPRGIAVD-KNGLMYFVDAT--MIRKVD-QNGIISTLLGS----NDLTAVRPLScdssmdvAQVrLEWPTD 1403
Cdd:PLN02919 620 ----DATFNRPQGLAYNaKKNLLYVADTEnhALREIDfVNETVRTLAGNgtkgSDYQGGKKGT-------SQV-LNSPWD 687
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973899 1404 LAVNPMDNSLYVlennvilRITENHQV---SIIAGRPMHCQVPGIDYSLS-KLAIHSALESASAIAIS-HTGVLYITETD 1478
Cdd:PLN02919 688 VCFEPVNEKVYI-------AMAGQHQIweyNISDGVTRVFSGDGYERNLNgSSGTSTSFAQPSGISLSpDLKELYIADSE 760
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568973899 1479 EKKINRLrQVTTNGEIcLLAGAasdcDCKNDVNCICYSGDDAYATDAILNSPSSLAVAPDGTIYIADLGNIRIR 1552
Cdd:PLN02919 761 SSSIRAL-DLKTGGSR-LLAGG----DPTFSDNLFKFGDHDGVGSEVLLQHPLGVLCAKDGQIYVADSYNHKIK 828
|
|
| DUF5885 |
pfam19232 |
Family of unknown function (DUF5885); This is a family of uncharacterized proteins of unknown ... |
575-734 |
6.82e-07 |
|
Family of unknown function (DUF5885); This is a family of uncharacterized proteins of unknown function found in viruses.
Pssm-ID: 437064 Cd Length: 265 Bit Score: 53.47 E-value: 6.82e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973899 575 DCPRNCHGNGECVSGLCH--------------CFPGFLGADCAKAAC--PVLCsGNGQ----------YSKGTCQ----C 624
Cdd:pfam19232 11 DCTPPCGGTQVCIDRQCKdntlacttdaqcgtCMTCVAGACTPKASCcgGVTC-GAGQtcdaktntcvYVKGYCSadhpC 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973899 625 YSGwkgAECDVPMNQCI-DPSCG-GHGS-CIDG-----------------NCVCAAG--YKGEH-CEEV--------DCL 673
Cdd:pfam19232 90 PSG---SACDTAKNACIaQPPYGpDSGKgCVRGfgawiweldpatnsgvwRCRCANGslYNSAHeCSPLadqtlcaaENL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973899 674 DPTC---------------SSHGVCVN-------------GECLCSPGWGGLNCELARvqcpdQCSGHGTYLPDSGLCSC 725
Cdd:pfam19232 167 DPNAlvpassvpafaaygwGNQPVLINkstagaavpsplaGVCPCKPGWAGGSCTEDR-----TCNGRGTWNETTGQCAC 241
|
250 260
....*....|....*....|....
gi 568973899 726 ------------DPN---WMGPDC 734
Cdd:pfam19232 242 nidfsghnscgdDNNctsWTGPRC 265
|
|
| C_rich_MXAN6577 |
NF041328 |
MXAN_6577-like cysteine-rich domain; |
644-790 |
7.74e-07 |
|
MXAN_6577-like cysteine-rich domain;
Pssm-ID: 469225 [Multi-domain] Cd Length: 145 Bit Score: 50.91 E-value: 7.74e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973899 644 SCGGHGS-CIDGNCVCaagykGEHCeeVDC-LDP--------TCSSHGVCVNGECLCSPGwgglncelaRVQCPDQCSgh 713
Cdd:NF041328 13 GCPEPGAvCPEGLSVC-----GGAC--VDLrSDPsncgacgvACGAGQTCVAGACGCGPG---------TVACGGACV-- 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973899 714 gtylpdsgLCSCDPNWMGpdcsveVCSVDCGTHGVCIGGACR--CEEGWT--GAAC-DQRVCHPRCIEHGT-CKDGKcEC 787
Cdd:NF041328 75 --------DTASDPAHCG------ACGAACAPGQVCEGGACReaCSEGLTrcGGACvDLATDPLHCGACGVaCDPGE-SC 139
|
...
gi 568973899 788 REG 790
Cdd:NF041328 140 RGG 142
|
|
| RHS_repeat |
pfam05593 |
RHS Repeat; RHS proteins contain extended repeat regions. These repeats often appear to be ... |
1666-1702 |
6.59e-05 |
|
RHS Repeat; RHS proteins contain extended repeat regions. These repeats often appear to be involved in ligand binding. Note that this model may not find all the repeats in a protein and that it covers two RHS repeats. The 3D structure of an RHS-repeat-containing protein (the B and C components of an ABC toxin complex) has been determined. The RHS repeats form an extended strip of beta-sheet that spirals around to form a hollow shell, encapsulating the variable C-terminal domain.
Pssm-ID: 461685 [Multi-domain] Cd Length: 37 Bit Score: 42.20 E-value: 6.59e-05
10 20 30
....*....|....*....|....*....|....*..
gi 568973899 1666 YDGNtGLLATKSDETGWTTFYDYDHEGRLTNVTRPTG 1702
Cdd:pfam05593 1 YDAA-GRLTSVTDPDGRVTTYTYDAAGRLTAVTDPDG 36
|
|
| DSL |
pfam01414 |
Delta serrate ligand; This family has been redefined to correspond to the EGF-like domain ... |
756-798 |
1.81e-03 |
|
Delta serrate ligand; This family has been redefined to correspond to the EGF-like domain defined by structure.
Pssm-ID: 460202 Cd Length: 46 Bit Score: 38.37 E-value: 1.81e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*.
gi 568973899 756 CEEGWTGAACDqRVCHPR--CIEHGTC-KDGKCECREGWNGEHCTI 798
Cdd:pfam01414 1 CDENYYGSTCS-KFCRPRddKFGHYTCdANGNKVCLPGWTGPYCDK 45
|
|
| EGF_CA |
cd00054 |
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
671-700 |
2.59e-03 |
|
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.
Pssm-ID: 238011 Cd Length: 38 Bit Score: 37.62 E-value: 2.59e-03
10 20 30
....*....|....*....|....*....|....*
gi 568973899 671 DCLDPT-CSSHGVCVNGE----CLCSPGWGGLNCE 700
Cdd:cd00054 4 ECASGNpCQNGGTCVNTVgsyrCSCPPGYTGRNCE 38
|
|
| EGF_CA |
cd00054 |
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
798-831 |
4.16e-03 |
|
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.
Pssm-ID: 238011 Cd Length: 38 Bit Score: 37.23 E-value: 4.16e-03
10 20 30
....*....|....*....|....*....|....*.
gi 568973899 798 IDGC--PDLCNGNGRCTLGQNSWQCVCQTGWRGPGC 831
Cdd:cd00054 2 IDECasGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
|
|
| C_rich_MXAN6577 |
NF041328 |
MXAN_6577-like cysteine-rich domain; |
739-811 |
4.35e-03 |
|
MXAN_6577-like cysteine-rich domain;
Pssm-ID: 469225 [Multi-domain] Cd Length: 145 Bit Score: 40.13 E-value: 4.35e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973899 739 CSVDCGTHGVCIGGACRCEEGWT--GAACDQRV--------CHPRCIEHGTCKDGKCE--CREGWngEHCTiDGCPDLCN 806
Cdd:NF041328 45 CGVACGAGQTCVAGACGCGPGTVacGGACVDTAsdpahcgaCGAACAPGQVCEGGACReaCSEGL--TRCG-GACVDLAT 121
|
....*
gi 568973899 807 GNGRC 811
Cdd:NF041328 122 DPLHC 126
|
|
| NHL_like_5 |
cd14963 |
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ... |
1527-1618 |
8.82e-03 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271333 [Multi-domain] Cd Length: 268 Bit Score: 40.74 E-value: 8.82e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973899 1527 LNSPSSLAVAPDGTIYIADLGNIRIRAVSKNKPVLNAFNQYE----AASPG-----EQELYVFNADGiHQYTVSLVTGEY 1597
Cdd:cd14963 55 FKYPYGIAVDSDGNIYVADLYNGRIQVFDPDGKFLKYFPEKKdrvkLISPAglaidDGKLYVSDVKK-HKVIVFDLEGKL 133
|
90 100
....*....|....*....|....*....
gi 568973899 1598 LYNF--------TYSADNDVTelIDNNGN 1618
Cdd:cd14963 134 LLEFgkpgsepgELSYPNGIA--VDEDGN 160
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| Ten_N |
pfam06484 |
Teneurin Intracellular Region; This family is found in the intracellular N-terminal region of ... |
10-374 |
0e+00 |
|
Teneurin Intracellular Region; This family is found in the intracellular N-terminal region of the Teneurin family of proteins. These proteins are 'pair-rule' genes and are involved in tissue patterning, specifically probably neural patterning. The intracellular domain is cleaved in response to homophilic interaction of the extracellular domain, and translocates to the nucleus. Here it probably carries out to some transcriptional regulatory activity. The length of this region and the conservation suggests that there may be two structural domains here (personal obs:C Yeats).
Pssm-ID: 461932 [Multi-domain] Cd Length: 367 Bit Score: 646.26 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973899 10 SLTRGRCGKECRYTSSSLDSEDCRVPTQKSYSSSETLKAYDHDSRMHYGNRVTDLVHRESDEFSRQGTNFTLAELGICEP 89
Cdd:pfam06484 1 SLTKRRRDKERRYTSSSADSEECRVPTQKSYSSSETLKAFDHDSRMLYGNRVKDMVHKEADEFSRQGQNFSLRELGICEP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973899 90 SP-HRSGYCSDMGILHQGYSLSTGSDADSDTEGGMSPEHAIRLWGRGIKSRRSSGLSSRENSALTLTDSDNENKSDDDNG 168
Cdd:pfam06484 81 SPrHGLAYCTEMGLPHRGYSISTGSDADTETDGPMSPEHAVRLWGRGTKSGRSSCLSSRSNSALTLTDTEHENKSDNENG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973899 169 RPIPPTSSSSLLPsaqlpSSHNPPP---VSCQMPLLDSNTSHQIMDTNPDEEFSPNSYLLRACSGPQQASSSGPPNHHSQ 245
Cdd:pfam06484 161 PPIPPSSSSSSPV-----EQHSPPPpslNENQRPLLGNNASHPILDSDPDEEFSPNSYLVRTGSGPQSAPSEQPPNFQNH 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973899 246 STLRPPLPP-PHNHT-LSHHHSSANSLNRNSLTNRRSQIHAP-APAPNDLATTPESVQLQDSWVLNSNVPLETRHFLFKT 322
Cdd:pfam06484 236 SRLRTPPPPlPPPHKqNQHHHPSINSLNRSSLTNRRNPSPAPtASLPAELQSTQESVQLQDSWVLNSNVPLETRHFLFKT 315
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 568973899 323 SSGSTPLFSSSSPGYPLTSGTVYTPPPRLLPRNTFSRKAFKLKKPSKYCSWK 374
Cdd:pfam06484 316 GTGTTPLFCTASPGYPLTSGTVYSPPPRPLPRNTFSRPAFKLKKPYKYCSWK 367
|
|
| NHL_like_1 |
cd14953 |
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ... |
1231-1554 |
1.04e-46 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271323 [Multi-domain] Cd Length: 323 Bit Score: 171.94 E-value: 1.04e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973899 1231 PVALAVGIDGSLFVGDF--NYIRRIFPSRNVTSIL---------------ELrNSPghkYYLAVDPvTGSLYVSDTNSRR 1293
Cdd:cd14953 25 PSGVAVDAAGNLYVADRgnHRIRKITPDGVVTTVAgtgtagfadgggaaaQF-NTP---SGVAVDA-AGNLYVADTGNHR 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973899 1294 IYRVkslsgakDLAGNSEVVAGTGEqclpfdeARCGDGGKAVDATLMSPRGIAVDKNGLMYFVDAT--MIRKVDQNGIIS 1371
Cdd:cd14953 100 IRKI-------TPDGVVSTLAGTGT-------AGFSDDGGATAAQFNYPTGVAVDAAGNLYVADTGnhRIRKITPDGVVT 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973899 1372 TLLGsndlTAVRPLSCDSSMDVAQVRleWPTDLAVNPMDNsLYVLE--NNVILRITENHQVSIIAGRPmhcqvpGIDYSL 1449
Cdd:cd14953 166 TVAG----TGGAGYAGDGPATAAQFN--NPTGVAVDAAGN-LYVADrgNHRIRKITPDGVVTTVAGTG------TAGFSG 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973899 1450 SKLAIHSALESASAIAISHTGVLYITETDEkkiNRLRQVTTNGEICLLAGAASDcdckndvncicYSGDDAYATDAILNS 1529
Cdd:cd14953 233 DGGATAAQLNNPTGVAVDAAGNLYVADSGN---HRIRKITPAGVVTTVAGGGAG-----------FSGDGGPATSAQFNN 298
|
330 340
....*....|....*....|....*
gi 568973899 1530 PSSLAVAPDGTIYIADLGNIRIRAV 1554
Cdd:cd14953 299 PTGVAVDAAGNLYVADTGNNRIRKI 323
|
|
| NHL_like_1 |
cd14953 |
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ... |
1275-1555 |
1.84e-40 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271323 [Multi-domain] Cd Length: 323 Bit Score: 153.84 E-value: 1.84e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973899 1275 LAVDPvTGSLYVSDTNSRRIYRVkslsgakDLAGNSEVVAGTGEqclpfdEARCGDGGKAvdATLMSPRGIAVDKNGLMY 1354
Cdd:cd14953 28 VAVDA-AGNLYVADRGNHRIRKI-------TPDGVVTTVAGTGT------AGFADGGGAA--AQFNTPSGVAVDAAGNLY 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973899 1355 FVDAT--MIRKVDQNGIISTLLGsndlTAVRPLSCDSSMDVAQvrLEWPTDLAVNPMDNsLYVLE--NNVILRITENHQV 1430
Cdd:cd14953 92 VADTGnhRIRKITPDGVVSTLAG----TGTAGFSDDGGATAAQ--FNYPTGVAVDAAGN-LYVADtgNHRIRKITPDGVV 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973899 1431 SIIAGRPmhcqVPGidYSLSKLAIHSALESASAIAISHTGVLYITETDEkkiNRLRQVTTNGEICLLAGAASDcdckndv 1510
Cdd:cd14953 165 TTVAGTG----GAG--YAGDGPATAAQFNNPTGVAVDAAGNLYVADRGN---HRIRKITPDGVVTTVAGTGTA------- 228
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 568973899 1511 ncicYSGDDAYATDAILNSPSSLAVAPDGTIYIADLGNIRIRAVS 1555
Cdd:cd14953 229 ----GFSGDGGATAAQLNNPTGVAVDAAGNLYVADSGNHRIRKIT 269
|
|
| Tox-GHH |
pfam15636 |
GHH signature containing HNH/Endo VII superfamily nuclease toxin; A predicted toxin of the HNH ... |
2674-2751 |
4.18e-37 |
|
GHH signature containing HNH/Endo VII superfamily nuclease toxin; A predicted toxin of the HNH/Endonuclease VII fold present in bacterial polymorphic toxin systems with a characteriztic sG[HQ]H signature motif. In bacterial polymorphic toxin systems, the toxin is exported by the type 2, type 6, type 7 or TcdB/TcaC-type secretion system. The metazoan teneurin proteins possess an inactive of this domain at their C-terminus.
Pssm-ID: 464783 Cd Length: 78 Bit Score: 135.05 E-value: 4.18e-37
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568973899 2674 EEKARVLDQARQRALGTAWAKEQQKARDGREGSRLWTEGEKQQLLSTGRVQGYEGYYVLPVEQYPELADSSSNIQFLR 2751
Cdd:pfam15636 1 EERKRLLEHAKKRAVREAWHRERQLLRNGLPGSRDWTDEEKEELLSTGSVPGYDGEYIHPVEQYPELADDPSNIRFRK 78
|
|
| NHL_like_1 |
cd14953 |
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ... |
1312-1555 |
6.02e-32 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271323 [Multi-domain] Cd Length: 323 Bit Score: 128.80 E-value: 6.02e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973899 1312 VVAGTGeqclpfdeARCGDGGKAVDATLMSPRGIAVDKNGLMYFVDAT--MIRKVDQNGIISTLL-----GSNDLTAvrp 1384
Cdd:cd14953 3 TVAGSG--------TAGFSGGGGTAARFNSPSGVAVDAAGNLYVADRGnhRIRKITPDGVVTTVAgtgtaGFADGGG--- 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973899 1385 lscdssmdvAQVRLEWPTDLAVNPMDNsLYV--LENNVILRITENHQVSIIAGRPmhcqVPGidYSLSKLAIHSALESAS 1462
Cdd:cd14953 72 ---------AAAQFNTPSGVAVDAAGN-LYVadTGNHRIRKITPDGVVSTLAGTG----TAG--FSDDGGATAAQFNYPT 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973899 1463 AIAISHTGVLYITETDEkkiNRLRQVTTNGEICLLAGAASDcdckndvncicYSGDDAYATDAILNSPSSLAVAPDGTIY 1542
Cdd:cd14953 136 GVAVDAAGNLYVADTGN---HRIRKITPDGVVTTVAGTGGA-----------GYAGDGPATAAQFNNPTGVAVDAAGNLY 201
|
250
....*....|...
gi 568973899 1543 IADLGNIRIRAVS 1555
Cdd:cd14953 202 VADRGNHRIRKIT 214
|
|
| RhsA |
COG3209 |
Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction ... |
1515-2452 |
2.12e-31 |
|
Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only];
Pssm-ID: 442442 [Multi-domain] Cd Length: 1103 Bit Score: 135.65 E-value: 2.12e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973899 1515 YSGDDAYATDAILNSPSSLAVAPDGTIYIADLGNIRIRAVSKNKPVLNAFNQYEAASP---GEQELYVFNADGIHQYTVS 1591
Cdd:COG3209 105 LTGLAAATASAGRLVSTGAGAGGTVTAATGGTLGATAGSATTGSTDGGRGGVAVTGLAgggASAYGLTLGGAAAGPATGV 184
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973899 1592 LVTGEYLYNFTYSADNDVTELIDNNGNSLKIRRDSSGMPRHLLMPDNQIITLTVGTNGGLKAVSTQNLELGLMTYDGNTG 1671
Cdd:COG3209 185 GTGAVTLATGLAGSALLALGSGAILGGLAGAYSGSATTATGTALGTPASVAATVTGSATGAAGAGAAVATAATTLGGTTG 264
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973899 1672 LLATKSDETGWTTFYDYDHEGRLTNVTRPTGVVTSLHREMEKSITIDIENSNRDDDVTVITNLSSVEASYTVVQDQVRNS 1751
Cdd:COG3209 265 AGTGASGAGLDASTGTGGAGGSNAAATAGGLGGAGLGSGGAGGGGTAGGTTTAAGTTGTAAVSGAADAGTTTTTGTGTGG 344
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973899 1752 YQLCNNGTLRVMYANGMAVSFHSEPHVLAGTITPTIGRCNISLPMENGLNSIEWRLRKEQIKGKVTIFGRKLRVHGRNLL 1831
Cdd:COG3209 345 TTTTVGGGGSLTLGGYGAAGGLTTSVGAGGGGSTSGSTTTVGGGGTATGSGGGSSTTGVGAGTTTTSTTGGDGGPATAAG 424
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973899 1832 SIDYDRNIRTEKIYDDHRKFTLRIIYDQVGRPFLWLPSSGLAAVNVSYFFNGRLAGLQRGAMSERTDIDKQGRIVSRMFA 1911
Cdd:COG3209 425 ALTAGGTATGTGTGGGGTTAGTDATTTTGGAGASGTLTTTGGAATGATTGGGTEAGTGGGTLTSGSAGATTLGTDTTLDD 504
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973899 1912 DGKVWSYSYLDKSMVLLLQSQRQYIF--------EYDSSDRLHAVTMPSVARHSMSTHTSIGYIRNIYNPPESNASVIFD 1983
Cdd:COG3209 505 TLGGTTTTTAGARGLVVTTGTTLTLGttttatlsATDATGTGDTTTTGTVGTGTSTGTGGTGTVTTTGDGTGGASTTTGT 584
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973899 1984 YSDDGRILKTSFLGTGRQVFYKYGKLSKLSEIVYDSTAVTFGYDETTGVLKMVNLQSGGFSCTIRYRKVGPLVDKQIYRF 2063
Cdd:COG3209 585 TGGTATTTTVTTTTTTSTAGTTTTTTSGYTRAGLTLTLGTGTASGLERATASTGSTTGGTTGTGVTTTGTTTTRATGTTG 664
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973899 2064 SEEGMINARFDYTYHDNSFRIASikpVISETPLPVDLYRYDEISGKVEHFGKFGVIYYDINQIITTAVMTLSKHFDTHGR 2143
Cdd:COG3209 665 TGTGVTAGLTTLATGGTTVGGGT---GTTSTATTGATTGGTETGTTVTTLAGGTTTRLGTTTTGGGGGTTTDGTGTGGTT 741
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973899 2144 IKEVQYEMF-RSLMYWMTVQYDSMGRVIKRELKLGPYANTTKYTYDYDGDGQLQSVAVNDRPTWRYSYDLNGNLH----- 2217
Cdd:COG3209 742 GTLTTTSTTtTTTAGALTYTYDALGRLTSETTPGGVTQGTYTTRYTYDALGRLTSVTYPDGETVTYTYDALGRLTsvitv 821
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973899 2218 LLNPGNSARLMPLRYDLRDRITRLGDVQykidDDGYLCQRgsdiFEYNSKGLLTRAynKASGWSVQYRYDGVGRRASyKT 2297
Cdd:COG3209 822 GSGGGTDLQDRTYTYDAAGNITSITDAL----RAGTLTQT----YTYDALGRLTSA--TDPGTTESYTYDANGNLTS-RT 890
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973899 2298 NLGHHlQYFYSDLHNPTRITHvynhSNSEITSLYYDLQGHlfamesssgeeyyvaSDNTGTPLAVFSINGLMIKQLQYTA 2377
Cdd:COG3209 891 DGGTT-TYTYDALGRLVSVTK----PDGTTTTYTYDALGH---------------TDHLGSVRALTDASGQVVWRYDYDP 950
|
890 900 910 920 930 940 950
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568973899 2378 YGEIYYDSNPDFQMVIGFHGGLYDPLTKLVHFTQRDYDVLAGRWTSPDytmwrNVGKEPAPfNLYMFKNNNPLSN 2452
Cdd:COG3209 951 FGNLLAETSGAAANPLRFTGQEYDAETGLYYNGARYYDPALGRFLSPD-----PIGLAGGL-NLYAYVGNNPVNY 1019
|
|
| NHL |
cd05819 |
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ... |
1226-1552 |
1.16e-17 |
|
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.
Pssm-ID: 271320 [Multi-domain] Cd Length: 269 Bit Score: 85.45 E-value: 1.16e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973899 1226 NKLLAPVALAVGIDGSLFVGDFNYIR-RIFPSRN--VTSILELRNSPGHKYY---LAVDPvTGSLYVSDTNSRRIYRVks 1299
Cdd:cd05819 5 GELNNPQGIAVDSSGNIYVADTGNNRiQVFDPDGnfITSFGSFGSGDGQFNEpagVAVDS-DGNLYVADTGNHRIQKF-- 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973899 1300 lsgakDLAGNSEVVAGTGeqclpfdearcGDGgkavDATLMSPRGIAVDKNGLMYFVDAT--MIRKVDQNGIISTLLGSN 1377
Cdd:cd05819 82 -----DPDGNFLASFGGS-----------GDG----DGEFNGPRGIAVDSSGNIYVADTGnhRIQKFDPDGEFLTTFGSG 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973899 1378 dltavrplscdsSMDVAQvrLEWPTDLAVNPmDNSLYVLE--NNVILRITENHQVSIIAGRPmhCQVPGidyslsklaih 1455
Cdd:cd05819 142 ------------GSGPGQ--FNGPTGVAVDS-DGNIYVADtgNHRIQVFDPDGNFLTTFGST--GTGPG----------- 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973899 1456 sALESASAIAISHTGVLYITETDEkkiNRLRQVTTNGEICLLAGaasdcdckndvncicysgdDAYATDAILNSPSSLAV 1535
Cdd:cd05819 194 -QFNYPTGIAVDSDGNIYVADSGN---NRVQVFDPDGAGFGGNG-------------------NFLGSDGQFNRPSGLAV 250
|
330
....*....|....*..
gi 568973899 1536 APDGTIYIADLGNIRIR 1552
Cdd:cd05819 251 DSDGNLYVADTGNNRIQ 267
|
|
| NHL |
cd05819 |
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ... |
1275-1573 |
1.24e-17 |
|
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.
Pssm-ID: 271320 [Multi-domain] Cd Length: 269 Bit Score: 85.45 E-value: 1.24e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973899 1275 LAVDPvTGSLYVSDTNSRRIYRVkslsgakDLAGNSEVVAGTGeqclpfdearcGDGgkavDATLMSPRGIAVDKNGLMY 1354
Cdd:cd05819 13 IAVDS-SGNIYVADTGNNRIQVF-------DPDGNFITSFGSF-----------GSG----DGQFNEPAGVAVDSDGNLY 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973899 1355 FVDAT--MIRKVDQNGIISTLLGSNDLTavrplscdssmdvaQVRLEWPTDLAVNPMDNsLYVL--ENNVILRITENHQV 1430
Cdd:cd05819 70 VADTGnhRIQKFDPDGNFLASFGGSGDG--------------DGEFNGPRGIAVDSSGN-IYVAdtGNHRIQKFDPDGEF 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973899 1431 SIIAGrpmhcqvpgidyslSKLAIHSALESASAIAISHTGVLYITETDEkkiNRLRQVTTNGEICLLAGaasdcdckndv 1510
Cdd:cd05819 135 LTTFG--------------SGGSGPGQFNGPTGVAVDSDGNIYVADTGN---HRIQVFDPDGNFLTTFG----------- 186
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568973899 1511 ncicysgdDAYATDAILNSPSSLAVAPDGTIYIADLGNIRIRAVSKNKPVLNAFNQYEAASPG 1573
Cdd:cd05819 187 --------STGTGPGQFNYPTGIAVDSDGNIYVADSGNNRVQVFDPDGAGFGGNGNFLGSDGQ 241
|
|
| NHL_like_1 |
cd14953 |
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ... |
1201-1364 |
1.31e-17 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271323 [Multi-domain] Cd Length: 323 Bit Score: 86.43 E-value: 1.31e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973899 1201 IITSIMGNGRRRSiscpSCNGLAEGNKLLAPVALAVGIDGSLFVGDF--NYIRRIFPSRNVTSILELR------------ 1266
Cdd:cd14953 163 VVTTVAGTGGAGY----AGDGPATAAQFNNPTGVAVDAAGNLYVADRgnHRIRKITPDGVVTTVAGTGtagfsgdggata 238
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973899 1267 ---NSPghkYYLAVDPvTGSLYVSDTNSRRIYRVkslsgakDLAGNSEVVAGTGeQCLPfdearcGDGGKAVDATLMSPR 1343
Cdd:cd14953 239 aqlNNP---TGVAVDA-AGNLYVADSGNHRIRKI-------TPAGVVTTVAGGG-AGFS------GDGGPATSAQFNNPT 300
|
170 180
....*....|....*....|...
gi 568973899 1344 GIAVDKNGLMYFVDAT--MIRKV 1364
Cdd:cd14953 301 GVAVDAAGNLYVADTGnnRIRKI 323
|
|
| NHL |
cd05819 |
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ... |
1220-1424 |
6.84e-15 |
|
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.
Pssm-ID: 271320 [Multi-domain] Cd Length: 269 Bit Score: 77.36 E-value: 6.84e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973899 1220 NGLAEGNkLLAPVALAVGIDGSLFVGDF--NYIRRIFPSRNVTSIL--------ELrNSPghkYYLAVDPvTGSLYVSDT 1289
Cdd:cd05819 94 SGDGDGE-FNGPRGIAVDSSGNIYVADTgnHRIQKFDPDGEFLTTFgsggsgpgQF-NGP---TGVAVDS-DGNIYVADT 167
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973899 1290 NSRRIYRVKSlsgakdlagNSEVVAGTGEQClpfdearcgdggkAVDATLMSPRGIAVDKNGLMYFVDATM--IRKVDQN 1367
Cdd:cd05819 168 GNHRIQVFDP---------DGNFLTTFGSTG-------------TGPGQFNYPTGIAVDSDGNIYVADSGNnrVQVFDPD 225
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 568973899 1368 GIISTLLGSNdltavrplscdssmDVAQVRLEWPTDLAVNPmDNSLYVLE--NNVILRI 1424
Cdd:cd05819 226 GAGFGGNGNF--------------LGSDGQFNRPSGLAVDS-DGNLYVADtgNNRIQVF 269
|
|
| NHL |
cd05819 |
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ... |
1336-1567 |
7.87e-15 |
|
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.
Pssm-ID: 271320 [Multi-domain] Cd Length: 269 Bit Score: 77.36 E-value: 7.87e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973899 1336 DATLMSPRGIAVDKNGLMYFVDATM--IRKVDQNGIISTLLGSNDltavrplscdssmdVAQVRLEWPTDLAVNPmDNSL 1413
Cdd:cd05819 4 PGELNNPQGIAVDSSGNIYVADTGNnrIQVFDPDGNFITSFGSFG--------------SGDGQFNEPAGVAVDS-DGNL 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973899 1414 YVL--ENNVILRITENHQVSIIAGRPmhcqvpGIDYSlsklaihsALESASAIAISHTGVLYITETDEkkiNRLRQVTTN 1491
Cdd:cd05819 69 YVAdtGNHRIQKFDPDGNFLASFGGS------GDGDG--------EFNGPRGIAVDSSGNIYVADTGN---HRIQKFDPD 131
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568973899 1492 GEIcllagaasdcdckndVNCICYSGddayATDAILNSPSSLAVAPDGTIYIADLGNIRIRAVSKNKPVLNAFNQY 1567
Cdd:cd05819 132 GEF---------------LTTFGSGG----SGPGQFNGPTGVAVDSDGNIYVADTGNHRIQVFDPDGNFLTTFGST 188
|
|
| NHL |
cd05819 |
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ... |
1227-1485 |
3.11e-13 |
|
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.
Pssm-ID: 271320 [Multi-domain] Cd Length: 269 Bit Score: 72.35 E-value: 3.11e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973899 1227 KLLAPVALAVGIDGSLFVGDFNYIR-RIFPS--RNVTSILELRNSPGHKYY---LAVDPvTGSLYVSDTNSRRIYRVksl 1300
Cdd:cd05819 53 QFNEPAGVAVDSDGNLYVADTGNHRiQKFDPdgNFLASFGGSGDGDGEFNGprgIAVDS-SGNIYVADTGNHRIQKF--- 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973899 1301 sgakDLAGNSEVVAGtgeqclpfdearcgdGGKAVDATLMSPRGIAVDKNGLMYFVDAT--MIRKVDQNGIISTLLGSNd 1378
Cdd:cd05819 129 ----DPDGEFLTTFG---------------SGGSGPGQFNGPTGVAVDSDGNIYVADTGnhRIQVFDPDGNFLTTFGST- 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973899 1379 ltavrplscdssmDVAQVRLEWPTDLAVNPMDNsLYVLE--NNVILRITENHQVSIIAGrpmhcqvpgidyslSKLAIHS 1456
Cdd:cd05819 189 -------------GTGPGQFNYPTGIAVDSDGN-IYVADsgNNRVQVFDPDGAGFGGNG--------------NFLGSDG 240
|
250 260
....*....|....*....|....*....
gi 568973899 1457 ALESASAIAISHTGVLYITETDEKKINRL 1485
Cdd:cd05819 241 QFNRPSGLAVDSDGNLYVADTGNNRIQVF 269
|
|
| Vgb |
COG4257 |
Streptogramin lyase [Defense mechanisms]; |
1231-1554 |
5.91e-13 |
|
Streptogramin lyase [Defense mechanisms];
Pssm-ID: 443399 [Multi-domain] Cd Length: 270 Bit Score: 71.59 E-value: 5.91e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973899 1231 PVALAVGIDGSLFVGDF--NYIRRIFP-SRNVTSILELRNSPGHKyyLAVDPvTGSLYVSDTNSRRIYRVkslsGAKDla 1307
Cdd:COG4257 19 PRDVAVDPDGAVWFTDQggGRIGRLDPaTGEFTEYPLGGGSGPHG--IAVDP-DGNLWFTDNGNNRIGRI----DPKT-- 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973899 1308 GNSEVVAGTGEQCLPFdearcgdggkavdatlmsprGIAVDKNGLMYFVDAT--MIRKVD-QNGIISTLlgsndltavrP 1384
Cdd:COG4257 90 GEITTFALPGGGSNPH--------------------GIAFDPDGNLWFTDQGgnRIGRLDpATGEVTEF----------P 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973899 1385 LSCDSSMdvaqvrlewPTDLAVNPmDNSLYV--LENNVILRI-TENHQVSIIAGrpmhcqvpgidyslsklaiHSALESA 1461
Cdd:COG4257 140 LPTGGAG---------PYGIAVDP-DGNLWVtdFGANAIGRIdPDTGTLTEYAL-------------------PTPGAGP 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973899 1462 SAIAISHTGVLYITETDEKKINRLRqvTTNGEIcllagaasdcdckndvncicysgdDAYATDAILNSPSSLAVAPDGTI 1541
Cdd:COG4257 191 RGLAVDPDGNLWVADTGSGRIGRFD--PKTGTV------------------------TEYPLPGGGARPYGVAVDGDGRV 244
|
330
....*....|...
gi 568973899 1542 YIADLGNIRIRAV 1554
Cdd:COG4257 245 WFAESGANRIVRF 257
|
|
| Vgb |
COG4257 |
Streptogramin lyase [Defense mechanisms]; |
1226-1494 |
3.64e-10 |
|
Streptogramin lyase [Defense mechanisms];
Pssm-ID: 443399 [Multi-domain] Cd Length: 270 Bit Score: 63.50 E-value: 3.64e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973899 1226 NKLLAPVALAVGIDGSLFVGD--FNYIRRIFPSRNVTSILELRNSPGHKYYLAVDPvTGSLYVSDTNSRRIYRVkslsga 1303
Cdd:COG4257 56 GGGSGPHGIAVDPDGNLWFTDngNNRIGRIDPKTGEITTFALPGGGSNPHGIAFDP-DGNLWFTDQGGNRIGRL------ 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973899 1304 kDLAGNsEVVAGTgeqcLPFDEARcgdggkavdatlmsPRGIAVDKNGLMYFVD--ATMIRKVD-QNGIISTLLGSNDLT 1380
Cdd:COG4257 129 -DPATG-EVTEFP----LPTGGAG--------------PYGIAVDPDGNLWVTDfgANAIGRIDpDTGTLTEYALPTPGA 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973899 1381 AvrplscdssmdvaqvrlewPTDLAVNPmDNSLYVLE--NNVILRITENhqvsiiagrpmhcqvpgiDYSLSKLAIHSAL 1458
Cdd:COG4257 189 G-------------------PRGLAVDP-DGNLWVADtgSGRIGRFDPK------------------TGTVTEYPLPGGG 230
|
250 260 270
....*....|....*....|....*....|....*.
gi 568973899 1459 ESASAIAISHTGVLYITETDekkINRLRQVTTNGEI 1494
Cdd:COG4257 231 ARPYGVAVDGDGRVWFAESG---ANRIVRFDPDTEL 263
|
|
| Rhs_assc_core |
TIGR03696 |
RHS repeat-associated core domain; This model represents a conserved unique core sequence ... |
2375-2452 |
7.51e-10 |
|
RHS repeat-associated core domain; This model represents a conserved unique core sequence shared by large numbers of proteins. It is occasional in the Archaea Methanosarcina barkeri) but common in bacteria and eukaryotes. Most fall into two large classes. One class consists of long proteins in which two classes of repeats are abundant: an FG-GAP repeat (pfam01839) class, and an RHS repeat (pfam05593) or YD repeat (TIGR01643). This class includes secreted bacterial insecticidal toxins and intercellular signalling proteins such as the teneurins in animals. The other class consists of uncharacterized proteins shorter than 400 amino acids, where this core domain of about 75 amino acids tends to occur in the N-terminal half. Over twenty such proteins are found in Pseudomonas putida alone; little sequence similarity or repeat structure is found among these proteins outside the region modeled by this domain.
Pssm-ID: 274730 [Multi-domain] Cd Length: 77 Bit Score: 57.51 E-value: 7.51e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973899 2375 YTAYGEIYYDSNPDFQmVIGFHGGLYDPLTKLVHFTQRDYDVLAGRWTSPDytmwrnvgkePA----PFNLYMFKNNNPL 2450
Cdd:TIGR03696 1 YDPYGEVLSESGAAPN-PLRFTGQYYDAETGLYYNGARYYDPELGRFLSPD----------PIglggGLNLYAYVGNNPV 69
|
..
gi 568973899 2451 SN 2452
Cdd:TIGR03696 70 NW 71
|
|
| Vgb |
COG4257 |
Streptogramin lyase [Defense mechanisms]; |
1273-1584 |
4.39e-09 |
|
Streptogramin lyase [Defense mechanisms];
Pssm-ID: 443399 [Multi-domain] Cd Length: 270 Bit Score: 60.03 E-value: 4.39e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973899 1273 YYLAVDPvTGSLYVSDTNSRRIYRVkslsgakDLAgnsevvagTGEqclpFDEARCGDGGkavdatlmSPRGIAVDKNGL 1352
Cdd:COG4257 20 RDVAVDP-DGAVWFTDQGGGRIGRL-------DPA--------TGE----FTEYPLGGGS--------GPHGIAVDPDGN 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973899 1353 MYFVD--ATMIRKVD-QNGIISTLLGSNDLTAvrplscdssmdvaqvrlewPTDLAVNPmDNSLYV--LENNVILRIT-E 1426
Cdd:COG4257 72 LWFTDngNNRIGRIDpKTGEITTFALPGGGSN-------------------PHGIAFDP-DGNLWFtdQGGNRIGRLDpA 131
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973899 1427 NHQVSIIAGRPMHCQvpgidyslsklaihsalesASAIAISHTGVLYITETdekKINRLRQVTT-NGEIcllagaasdcd 1505
Cdd:COG4257 132 TGEVTEFPLPTGGAG-------------------PYGIAVDPDGNLWVTDF---GANAIGRIDPdTGTL----------- 178
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973899 1506 ckndvncicysgdDAYATDAILNSPSSLAVAPDGTIYIADLGNIRIRAVSknkPVLNAFNQYeAASPGEQELY--VFNAD 1583
Cdd:COG4257 179 -------------TEYALPTPGAGPRGLAVDPDGNLWVADTGSGRIGRFD---PKTGTVTEY-PLPGGGARPYgvAVDGD 241
|
.
gi 568973899 1584 G 1584
Cdd:COG4257 242 G 242
|
|
| acid_disulf_rpt |
NF033662 |
acidic double-disulfide repeat; The acidic double-disulfide repeat is an Asp-rich repeat with ... |
834-864 |
4.11e-08 |
|
acidic double-disulfide repeat; The acidic double-disulfide repeat is an Asp-rich repeat with four nearly invariant Cys residues in a repeat length of about 35 amino acids.
Pssm-ID: 411265 [Multi-domain] Cd Length: 32 Bit Score: 50.98 E-value: 4.11e-08
10 20 30
....*....|....*....|....*....|.
gi 568973899 834 AMETSCADNKDNEGDGLVDCLDPDCCLQSAC 864
Cdd:NF033662 2 ATDTTCSDGIDNDGDGLTDCADPDCAGNPVC 32
|
|
| NHL_like_5 |
cd14963 |
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ... |
1224-1422 |
5.20e-08 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271333 [Multi-domain] Cd Length: 268 Bit Score: 56.92 E-value: 5.20e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973899 1224 EGNKLLAPVALAVgIDGSLFVGDFNYIRRIFPSRNVTSILELRN---SPGHKYY---LAVDPvTGSLYVSDTNSRRIyrv 1297
Cdd:cd14963 97 DRVKLISPAGLAI-DDGKLYVSDVKKHKVIVFDLEGKLLLEFGKpgsEPGELSYpngIAVDE-DGNIYVADSGNGRI--- 171
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973899 1298 kslsgakdlagnsevvagtgeQCLPFDE--ARCGDGGKAVDATLMSPRGIAVDKNGLMYFVD--ATMIRKVDQNGIISTL 1373
Cdd:cd14963 172 ---------------------QVFDKNGkfIKELNGSPDGKSGFVNPRGIAVDPDGNLYVVDnlSHRVYVFDEQGKELFT 230
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 568973899 1374 LGsndltavrplscdsSMDVAQVRLEWPTDLAVNPmDNSLYV--LENNVIL 1422
Cdd:cd14963 231 FG--------------GRGKDDGQFNLPNGLFIDD-DGRLYVtdRENNRVA 266
|
|
| NHL_PKND_like |
cd14952 |
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ... |
1275-1551 |
7.09e-08 |
|
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271322 [Multi-domain] Cd Length: 247 Bit Score: 56.06 E-value: 7.09e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973899 1275 LAVDPvTGSLYVSDTNSRRIYRvkslsgakdLAgnsevvAGTGEQC-LPFDEarcgdggkavdatLMSPRGIAVDKNGLM 1353
Cdd:cd14952 15 VAVDA-AGNVYVADSGNNRVLK---------LA------AGSTTQTvLPFTG-------------LYQPQGVAVDAAGTV 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973899 1354 YFVDAtmirkvDQNGIISTLLGSNDLTAVrPLScdssmdvaqvRLEWPTDLAVNPMDNsLYVLE--NNVILRITenhqvs 1431
Cdd:cd14952 66 YVTDF------GNNRVLKLAAGSTTQTVL-PFT----------GLNDPTGVAVDAAGN-VYVADtgNNRVLKLA------ 121
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973899 1432 iiAGRPMHCQVPGIDyslsklaihsaLESASAIAISHTGVLYITETDEKKINRLRQVTT-------NGeicLLAGAASDC 1504
Cdd:cd14952 122 --AGSNTQTVLPFTG-----------LSNPDGVAVDGAGNVYVTDTGNNRVLKLAAGSTtqtvlpfTG---LNSPSGVAV 185
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568973899 1505 DCKNDVncicYSGD---------DAYATDAI------LNSPSSLAVAPDGTIYIADLGNIRI 1551
Cdd:cd14952 186 DTAGNV----YVTDhgnnrvlklAAGSTTPTvlpftgLNGPLGVAVDAAGNVYVADRGNDRV 243
|
|
| PLN02919 |
PLN02919 |
haloacid dehalogenase-like hydrolase family protein |
1256-1552 |
2.40e-07 |
|
haloacid dehalogenase-like hydrolase family protein
Pssm-ID: 215497 [Multi-domain] Cd Length: 1057 Bit Score: 56.78 E-value: 2.40e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973899 1256 SRNVTSILELrnsPGHkyyLAVDPVTGSLYVSDTNSRRIYrvkslsgAKDLAGNSEV-VAGTGEQCL---PFDearcgdg 1331
Cdd:PLN02919 560 PRLLTSPLKF---PGK---LAIDLLNNRLFISDSNHNRIV-------VTDLDGNFIVqIGSTGEEGLrdgSFE------- 619
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973899 1332 gkavDATLMSPRGIAVD-KNGLMYFVDAT--MIRKVD-QNGIISTLLGS----NDLTAVRPLScdssmdvAQVrLEWPTD 1403
Cdd:PLN02919 620 ----DATFNRPQGLAYNaKKNLLYVADTEnhALREIDfVNETVRTLAGNgtkgSDYQGGKKGT-------SQV-LNSPWD 687
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973899 1404 LAVNPMDNSLYVlennvilRITENHQV---SIIAGRPMHCQVPGIDYSLS-KLAIHSALESASAIAIS-HTGVLYITETD 1478
Cdd:PLN02919 688 VCFEPVNEKVYI-------AMAGQHQIweyNISDGVTRVFSGDGYERNLNgSSGTSTSFAQPSGISLSpDLKELYIADSE 760
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568973899 1479 EKKINRLrQVTTNGEIcLLAGAasdcDCKNDVNCICYSGDDAYATDAILNSPSSLAVAPDGTIYIADLGNIRIR 1552
Cdd:PLN02919 761 SSSIRAL-DLKTGGSR-LLAGG----DPTFSDNLFKFGDHDGVGSEVLLQHPLGVLCAKDGQIYVADSYNHKIK 828
|
|
| DUF5885 |
pfam19232 |
Family of unknown function (DUF5885); This is a family of uncharacterized proteins of unknown ... |
575-734 |
6.82e-07 |
|
Family of unknown function (DUF5885); This is a family of uncharacterized proteins of unknown function found in viruses.
Pssm-ID: 437064 Cd Length: 265 Bit Score: 53.47 E-value: 6.82e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973899 575 DCPRNCHGNGECVSGLCH--------------CFPGFLGADCAKAAC--PVLCsGNGQ----------YSKGTCQ----C 624
Cdd:pfam19232 11 DCTPPCGGTQVCIDRQCKdntlacttdaqcgtCMTCVAGACTPKASCcgGVTC-GAGQtcdaktntcvYVKGYCSadhpC 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973899 625 YSGwkgAECDVPMNQCI-DPSCG-GHGS-CIDG-----------------NCVCAAG--YKGEH-CEEV--------DCL 673
Cdd:pfam19232 90 PSG---SACDTAKNACIaQPPYGpDSGKgCVRGfgawiweldpatnsgvwRCRCANGslYNSAHeCSPLadqtlcaaENL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973899 674 DPTC---------------SSHGVCVN-------------GECLCSPGWGGLNCELARvqcpdQCSGHGTYLPDSGLCSC 725
Cdd:pfam19232 167 DPNAlvpassvpafaaygwGNQPVLINkstagaavpsplaGVCPCKPGWAGGSCTEDR-----TCNGRGTWNETTGQCAC 241
|
250 260
....*....|....*....|....
gi 568973899 726 ------------DPN---WMGPDC 734
Cdd:pfam19232 242 nidfsghnscgdDNNctsWTGPRC 265
|
|
| C_rich_MXAN6577 |
NF041328 |
MXAN_6577-like cysteine-rich domain; |
644-790 |
7.74e-07 |
|
MXAN_6577-like cysteine-rich domain;
Pssm-ID: 469225 [Multi-domain] Cd Length: 145 Bit Score: 50.91 E-value: 7.74e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973899 644 SCGGHGS-CIDGNCVCaagykGEHCeeVDC-LDP--------TCSSHGVCVNGECLCSPGwgglncelaRVQCPDQCSgh 713
Cdd:NF041328 13 GCPEPGAvCPEGLSVC-----GGAC--VDLrSDPsncgacgvACGAGQTCVAGACGCGPG---------TVACGGACV-- 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973899 714 gtylpdsgLCSCDPNWMGpdcsveVCSVDCGTHGVCIGGACR--CEEGWT--GAAC-DQRVCHPRCIEHGT-CKDGKcEC 787
Cdd:NF041328 75 --------DTASDPAHCG------ACGAACAPGQVCEGGACReaCSEGLTrcGGACvDLATDPLHCGACGVaCDPGE-SC 139
|
...
gi 568973899 788 REG 790
Cdd:NF041328 140 RGG 142
|
|
| NHL_like_2 |
cd14957 |
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ... |
1339-1618 |
6.64e-06 |
|
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271327 [Multi-domain] Cd Length: 280 Bit Score: 50.34 E-value: 6.64e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973899 1339 LMSPRGIAVDKNGLMYFVDA--TMIRKVDQNGIISTLLGSNDLTavrplscdssmdvaQVRLEWPTDLAVNPMDNsLYVL 1416
Cdd:cd14957 17 FNTPRGIAVDSAGNIYVADTgnNRIQVFTSSGVYSYSIGSGGTG--------------SGQFNSPYGIAVDSNGN-IYVA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973899 1417 EnnvilriTENHQVSII--AGrpmhcqvpGIDYSL-SKLAIHSALESASAIAISHTGVLYITETDEkkiNRLRQVTTNGE 1493
Cdd:cd14957 82 D-------TDNNRIQVFnsSG--------VYQYSIgTGGSGDGQFNGPYGIAVDSNGNIYVADTGN---HRIQVFTSSGT 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973899 1494 ICllagaasdcdckndvncicYSGDDAYATDAILNSPSSLAVAPDGTIYIADLGNIRIRavsknkpvlnafnqyeaaspg 1573
Cdd:cd14957 144 FS-------------------YSIGSGGTGPGQFNGPQGIAVDSDGNIYVADTGNHRIQ--------------------- 183
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 568973899 1574 eqelyVFNADGIHQYTV-SLVTGEYLYNFTYsadnDVTelIDNNGN 1618
Cdd:cd14957 184 -----VFTSSGTFQYTFgSSGSGPGQFSDPY----GIA--VDSDGN 218
|
|
| NHL_like_2 |
cd14957 |
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ... |
1231-1357 |
8.24e-06 |
|
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271327 [Multi-domain] Cd Length: 280 Bit Score: 50.34 E-value: 8.24e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973899 1231 PVALAVGIDGSLFVGD-FNYIRRIFPSRNVT--SILELRNSPGHKYYL---AVDPvTGSLYVSDTNSRRIyRVKSLSGAK 1304
Cdd:cd14957 114 PYGIAVDSNGNIYVADtGNHRIQVFTSSGTFsySIGSGGTGPGQFNGPqgiAVDS-DGNIYVADTGNHRI-QVFTSSGTF 191
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 568973899 1305 DLAgnsevVAGTGEqclpfdearcGDGGkavdatLMSPRGIAVDKNGLMYFVD 1357
Cdd:cd14957 192 QYT-----FGSSGS----------GPGQ------FSDPYGIAVDSDGNIYVAD 223
|
|
| NHL_PKND_like |
cd14952 |
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ... |
1228-1415 |
1.48e-05 |
|
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271322 [Multi-domain] Cd Length: 247 Bit Score: 49.13 E-value: 1.48e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973899 1228 LLAPVALAVGIDGSLFVGDFNYIR--RIFPSRNVTSILELR--NSPGHkyyLAVDPVtGSLYVSDTNSRRIYRVKS---- 1299
Cdd:cd14952 51 LYQPQGVAVDAAGTVYVTDFGNNRvlKLAAGSTTQTVLPFTglNDPTG---VAVDAA-GNVYVADTGNNRVLKLAAgsnt 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973899 1300 --------LSGAKDLA------------GNSEVV---AGTGEQC-LPFDEarcgdggkavdatLMSPRGIAVDKNGLMYF 1355
Cdd:cd14952 127 qtvlpftgLSNPDGVAvdgagnvyvtdtGNNRVLklaAGSTTQTvLPFTG-------------LNSPSGVAVDTAGNVYV 193
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973899 1356 VDAtmirkvDQNGIISTLLGSNDLTAVrPLScdssmdvaqvRLEWPTDLAVNPmDNSLYV 1415
Cdd:cd14952 194 TDH------GNNRVLKLAAGSTTPTVL-PFT----------GLNGPLGVAVDA-AGNVYV 235
|
|
| NHL_like_1 |
cd14953 |
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ... |
1516-1557 |
2.01e-05 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271323 [Multi-domain] Cd Length: 323 Bit Score: 49.45 E-value: 2.01e-05
10 20 30 40
....*....|....*....|....*....|....*....|..
gi 568973899 1516 SGDDAYATDAILNSPSSLAVAPDGTIYIADLGNIRIRAVSKN 1557
Cdd:cd14953 11 GFSGGGGTAARFNSPSGVAVDAAGNLYVADRGNHRIRKITPD 52
|
|
| RHS_repeat |
pfam05593 |
RHS Repeat; RHS proteins contain extended repeat regions. These repeats often appear to be ... |
1666-1702 |
6.59e-05 |
|
RHS Repeat; RHS proteins contain extended repeat regions. These repeats often appear to be involved in ligand binding. Note that this model may not find all the repeats in a protein and that it covers two RHS repeats. The 3D structure of an RHS-repeat-containing protein (the B and C components of an ABC toxin complex) has been determined. The RHS repeats form an extended strip of beta-sheet that spirals around to form a hollow shell, encapsulating the variable C-terminal domain.
Pssm-ID: 461685 [Multi-domain] Cd Length: 37 Bit Score: 42.20 E-value: 6.59e-05
10 20 30
....*....|....*....|....*....|....*..
gi 568973899 1666 YDGNtGLLATKSDETGWTTFYDYDHEGRLTNVTRPTG 1702
Cdd:pfam05593 1 YDAA-GRLTSVTDPDGRVTTYTYDAAGRLTAVTDPDG 36
|
|
| NHL_like_2 |
cd14957 |
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ... |
1231-1552 |
7.06e-05 |
|
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271327 [Multi-domain] Cd Length: 280 Bit Score: 47.26 E-value: 7.06e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973899 1231 PVALAVGIDGSLFVGDFNYIR-RIFPSRNV--TSILELRNSPGH---KYYLAVDPvTGSLYVSDTNSRRIyRVKSLSGAK 1304
Cdd:cd14957 20 PRGIAVDSAGNIYVADTGNNRiQVFTSSGVysYSIGSGGTGSGQfnsPYGIAVDS-NGNIYVADTDNNRI-QVFNSSGVY 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973899 1305 DLAgnsevVAGTGEQCLPFDEarcgdggkavdatlmsPRGIAVDKNGLMYFVDA--TMIRKVDQNGIISTLLGSndltav 1382
Cdd:cd14957 98 QYS-----IGTGGSGDGQFNG----------------PYGIAVDSNGNIYVADTgnHRIQVFTSSGTFSYSIGS------ 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973899 1383 rplscdSSMDVAQVRLewPTDLAVNPMDNsLYVLENNvilriteNHQVSII--AGRPmhcqvpgiDYSL-SKLAIHSALE 1459
Cdd:cd14957 151 ------GGTGPGQFNG--PQGIAVDSDGN-IYVADTG-------NHRIQVFtsSGTF--------QYTFgSSGSGPGQFS 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973899 1460 SASAIAISHTGVLYITETDEKKInrlrQVTTNgeicllagaasdcdckndvncicySGDDAYA------TDAILNSPSSL 1533
Cdd:cd14957 207 DPYGIAVDSDGNIYVADTGNHRI----QVFTS------------------------SGAYQYSigtsgsGNGQFNYPYGI 258
|
330
....*....|....*....
gi 568973899 1534 AVAPDGTIYIADLGNIRIR 1552
Cdd:cd14957 259 AVDNDGKIYVADSNNNRIQ 277
|
|
| Keratin_B2 |
pfam01500 |
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ... |
667-785 |
2.78e-04 |
|
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.
Pssm-ID: 366678 [Multi-domain] Cd Length: 161 Bit Score: 44.01 E-value: 2.78e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973899 667 CEEVDCLDPTCSSHGVCvnGECLCSPGWGGLNCelarvqCPDQCSGHGTYLPDSGLCSCDPNWMGPDCSVEVCSVDCGTH 746
Cdd:pfam01500 4 CGTSFCGFPTCSTGGTC--GSGCCQPCCCQSSC------CRPSCCQTSCCQPTTFQSSCCRPTCQPCCQTSCCQPTCCQT 75
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 568973899 747 GVCIGGACRCEEGWTGAA----CDQRVCHPRCIEHGTCKDGKC 785
Cdd:pfam01500 76 SSCQTGCGGIGYGQEGSSgavsSRTRWCRPDCRVEGTCLPPCC 118
|
|
| EGF_2 |
pfam07974 |
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins. |
580-602 |
7.40e-04 |
|
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
Pssm-ID: 400365 Cd Length: 26 Bit Score: 38.87 E-value: 7.40e-04
|
| YvrE |
COG3386 |
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ... |
1234-1387 |
1.01e-03 |
|
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway
Pssm-ID: 442613 [Multi-domain] Cd Length: 266 Bit Score: 43.73 E-value: 1.01e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973899 1234 LAVGIDGSLFVGDFNY------IRRIFPSRNVTSILE-LRNSPGhkyyLAVDPVTGSLYVSDTNSRRIYRVkslsgakDL 1306
Cdd:COG3386 98 GVVDPDGRLYFTDMGEylptgaLYRVDPDGSLRVLADgLTFPNG----IAFSPDGRTLYVADTGAGRIYRF-------DL 166
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973899 1307 AGNSEVVAGTgeqclPFDEARCGDGGkavdatlmsPRGIAVDKNGLMY--FVDATMIRKVDQNGiisTLLGSNDLTAVRP 1384
Cdd:COG3386 167 DADGTLGNRR-----VFADLPDGPGG---------PDGLAVDADGNLWvaLWGGGGVVRFDPDG---ELLGRIELPERRP 229
|
...
gi 568973899 1385 LSC 1387
Cdd:COG3386 230 TNV 232
|
|
| DSL |
pfam01414 |
Delta serrate ligand; This family has been redefined to correspond to the EGF-like domain ... |
756-798 |
1.81e-03 |
|
Delta serrate ligand; This family has been redefined to correspond to the EGF-like domain defined by structure.
Pssm-ID: 460202 Cd Length: 46 Bit Score: 38.37 E-value: 1.81e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*.
gi 568973899 756 CEEGWTGAACDqRVCHPR--CIEHGTC-KDGKCECREGWNGEHCTI 798
Cdd:pfam01414 1 CDENYYGSTCS-KFCRPRddKFGHYTCdANGNKVCLPGWTGPYCDK 45
|
|
| EGF_2 |
pfam07974 |
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins. |
645-667 |
2.57e-03 |
|
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
Pssm-ID: 400365 Cd Length: 26 Bit Score: 37.33 E-value: 2.57e-03
|
| EGF_CA |
cd00054 |
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
671-700 |
2.59e-03 |
|
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.
Pssm-ID: 238011 Cd Length: 38 Bit Score: 37.62 E-value: 2.59e-03
10 20 30
....*....|....*....|....*....|....*
gi 568973899 671 DCLDPT-CSSHGVCVNGE----CLCSPGWGGLNCE 700
Cdd:cd00054 4 ECASGNpCQNGGTCVNTVgsyrCSCPPGYTGRNCE 38
|
|
| NHL_like_6 |
cd14962 |
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ... |
1273-1477 |
3.14e-03 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271332 [Multi-domain] Cd Length: 271 Bit Score: 42.19 E-value: 3.14e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973899 1273 YYLAVDPvTGSLYVSDTNSRRIYRvkslsgakdlagnsevvagtgeqclpFDEARcgdG-----GKAVDATLMSPRGIAV 1347
Cdd:cd14962 15 YGVAADG-RGRIYVADTGRGAVFV--------------------------FDLPN---GkvfviGNAGPNRFVSPIGVAI 64
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973899 1348 DKNGLMYFVDAT--MIRKVDQNGIISTLLGSNDLtavrplscdssmdvaQVRlewPTDLAVNPMDNSLYVLEnnvilriT 1425
Cdd:cd14962 65 DANGNLYVSDAElgKVFVFDRDGKFLRAIGAGAL---------------FKR---PTGIAVDPAGKRLYVVD-------T 119
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 568973899 1426 ENHQVSIIAGRPMHCQVPGIDYSlsklaIHSALESASAIAISHTGVLYITET 1477
Cdd:cd14962 120 LAHKVKVFDLDGRLLFDIGKRGS-----GPGEFNLPTDLAVDRDGNLYVTDT 166
|
|
| EGF_2 |
pfam07974 |
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins. |
710-734 |
3.56e-03 |
|
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
Pssm-ID: 400365 Cd Length: 26 Bit Score: 36.94 E-value: 3.56e-03
|
| EGF_CA |
cd00054 |
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
638-668 |
3.70e-03 |
|
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.
Pssm-ID: 238011 Cd Length: 38 Bit Score: 37.23 E-value: 3.70e-03
10 20 30
....*....|....*....|....*....|....*.
gi 568973899 638 NQCIDPS-CGGHGSCIDG----NCVCAAGYKGEHCE 668
Cdd:cd00054 3 DECASGNpCQNGGTCVNTvgsyRCSCPPGYTGRNCE 38
|
|
| YD_repeat_2x |
TIGR01643 |
YD repeat (two copies); This model describes two tandem copies of a 21-residue extracellular ... |
1666-1708 |
3.76e-03 |
|
YD repeat (two copies); This model describes two tandem copies of a 21-residue extracellular repeat found in Gram-negative, Gram-positive, and animal proteins. The repeat is named for a YD dipeptide, the most strongly conserved motif of the repeat. These repeats appear in general to be involved in binding carbohydrate; the chicken teneurin-1 YD-repeat region has been shown to bind heparin.
Pssm-ID: 273728 [Multi-domain] Cd Length: 42 Bit Score: 37.18 E-value: 3.76e-03
10 20 30 40
....*....|....*....|....*....|....*....|...
gi 568973899 1666 YDGNtGLLATKSDETGWTTFYDYDHEGRLTNVTRPTGVVTSLH 1708
Cdd:TIGR01643 1 YDAA-GRLTGSTDADGTTTRYTYDAAGRLVEITDADGGSTRYE 42
|
|
| EGF_CA |
cd00054 |
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
798-831 |
4.16e-03 |
|
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.
Pssm-ID: 238011 Cd Length: 38 Bit Score: 37.23 E-value: 4.16e-03
10 20 30
....*....|....*....|....*....|....*.
gi 568973899 798 IDGC--PDLCNGNGRCTLGQNSWQCVCQTGWRGPGC 831
Cdd:cd00054 2 IDECasGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
|
|
| C_rich_MXAN6577 |
NF041328 |
MXAN_6577-like cysteine-rich domain; |
739-811 |
4.35e-03 |
|
MXAN_6577-like cysteine-rich domain;
Pssm-ID: 469225 [Multi-domain] Cd Length: 145 Bit Score: 40.13 E-value: 4.35e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973899 739 CSVDCGTHGVCIGGACRCEEGWT--GAACDQRV--------CHPRCIEHGTCKDGKCE--CREGWngEHCTiDGCPDLCN 806
Cdd:NF041328 45 CGVACGAGQTCVAGACGCGPGTVacGGACVDTAsdpahcgaCGAACAPGQVCEGGACReaCSEGL--TRCG-GACVDLAT 121
|
....*
gi 568973899 807 GNGRC 811
Cdd:NF041328 122 DPLHC 126
|
|
| SOBP |
pfam15279 |
Sine oculis-binding protein; SOBP is associated with syndromic and nonsyndromic intellectual ... |
185-349 |
5.75e-03 |
|
Sine oculis-binding protein; SOBP is associated with syndromic and nonsyndromic intellectual disability. It carries a zinc-finger of the zf-C2H2 type at the N-terminus, and a highly characteriztic C-terminal PhPhPhPhPhPh motif. The deduced 873-amino acid protein contains an N-terminal nuclear localization signal (NLS), followed by 2 FCS-type zinc finger motifs, a proline-rich region (PR1), a putative RNA-binding motif region, and a C-terminal NLS embedded in a second proline-rich motif. SOBP is expressed in various human tissues, including developing mouse brain at embryonic day 14. In postnatal and adult mouse brain SOBP is expressed in all neurons, with intense staining in the limbic system. Highest expression is in layer V cortical neurons, hippocampus, pyriform cortex, dorsomedial nucleus of thalamus, amygdala, and hypothalamus. Postnatal expression of SOBP in the limbic system corresponds to a time of active synaptogenesis. the family is also referred to as Jackson circler, JXC1. In seven affected siblings from a consanguineous Israeli Arab family with mental retardation, anterior maxillary protrusion, and strabismus mutations were found in this protein.
Pssm-ID: 464609 [Multi-domain] Cd Length: 325 Bit Score: 41.72 E-value: 5.75e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973899 185 LPSSHNPPPVScQMPLLDSNTSHQIMDTNPDEEF----SPNSYLLRACSGPQQ---ASSSGPPNHHSQSTLRPPLPPPhn 257
Cdd:pfam15279 127 APKPHEPPSLP-PPPLPPKKGRRHRPGLHPPLGRppgsPPMSMTPRGLLGKPQqhpPPSPLPAFMEPSSMPPPFLRPP-- 203
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973899 258 htlsHHHSSANSlnrnSLTNRRSQIHAPAPAP-NDLATTPEsvqlqdswvlnsnvPLEtRHFLFKTSSGSTPLFSSSSPG 336
Cdd:pfam15279 204 ----PSIPQPNS----PLSNPMLPGIGPPPKPpRNLGPPSN--------------PMH-RPPFSPHHPPPPPTPPGPPPG 260
|
170
....*....|...
gi 568973899 337 YPLTSGTVYTPPP 349
Cdd:pfam15279 261 LPPPPPRGFTPPF 273
|
|
| NHL-2_like |
cd14951 |
NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL ... |
1469-1554 |
8.28e-03 |
|
NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL repeat-containing protein 2 (NHLRC2) and related bacterial proteins; members of this eukaryotic and bacterial family are uncharacterized, the NHL repeat domain is found C-terminally of a thioredoxin domain. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271321 [Multi-domain] Cd Length: 334 Bit Score: 41.02 E-value: 8.28e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973899 1469 TGVLYITETDEKKINRL----RQVTTngeiclLAGaasdcdckndvncicySGDDAYA-TDAILNSPSSLAVAPDGTIYI 1543
Cdd:cd14951 206 DGSVYVADTYNHKIKRVdpatGEVST------LAG----------------TGKAGYKdLEAQFSEPSGLVVDGDGRLYV 263
|
90
....*....|.
gi 568973899 1544 ADLGNIRIRAV 1554
Cdd:cd14951 264 ADTNNHRIRRL 274
|
|
| NHL_like_5 |
cd14963 |
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ... |
1527-1618 |
8.82e-03 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271333 [Multi-domain] Cd Length: 268 Bit Score: 40.74 E-value: 8.82e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973899 1527 LNSPSSLAVAPDGTIYIADLGNIRIRAVSKNKPVLNAFNQYE----AASPG-----EQELYVFNADGiHQYTVSLVTGEY 1597
Cdd:cd14963 55 FKYPYGIAVDSDGNIYVADLYNGRIQVFDPDGKFLKYFPEKKdrvkLISPAglaidDGKLYVSDVKK-HKVIVFDLEGKL 133
|
90 100
....*....|....*....|....*....
gi 568973899 1598 LYNF--------TYSADNDVTelIDNNGN 1618
Cdd:cd14963 134 LLEFgkpgsepgELSYPNGIA--VDEDGN 160
|
|
| |
