NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|568974975|ref|XP_006533872|]
View 

solute carrier family 22 member 21 isoform X6 [Mus musculus]

Protein Classification

MFS transporter( domain architecture ID 1000272)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates; similar to Drosophila melanogaster organic cation transporter protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
2A0119 super family cl36765
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
 2-303 3.77e-137

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


The actual alignment was detected with superfamily member TIGR00898:

Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 399.01  E-value: 3.77e-137
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974975    2 LSKSVRIIFATLGvCIFFAFGFMVLPLFAYFIREWRRLLLAITLPGVLCGALWWFIPESPRWLISQGRIKEAEVIIRKAA 81
Cdd:TIGR00898 209 LPKKQRAIVGTLI-QVFFSLGLVLLPLVAYFIPDWRWLQLAVSLPTFLFFLLSWFVPESPRWLISQGRIEEALKILQRIA 287

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974975   82 KINGIVAPSTIFDPSETnklQDDSSKKPQsHHIYDLVRTPNIRILTIMSIILWLTISVGYFGLSLDTPNLNGNIYVNCFL 161
Cdd:TIGR00898 288 KINGKKLPAEVLSLSLE---KDLSSSKKQ-YSFLDLFRTPNLRKTTLCLMMLWFTTAFSYYGLVLDLGNLGGNIYLDLFI 363

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974975  162 LAAVEVPAYVLAWLLLQHVSRRYSMAGSLFLGGSVLLLVQLVPSDLHYLSTTLVMVGKFGITSAYSMVYVYTAELYPTVV 241
Cdd:TIGR00898 364 SGLVELPAKLITLLLIDRLGRRYTMAASLLLAGVALLLLLFVPVDLYFLRTALAVLGKFGITSAFQMVYLYTAELYPTVV 443

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568974975  242 RNMGVGVSSTASRLGSILSPYFVYLGAYDRRLPYILMGSLTILTAIITLFFPESSGVSLPET 303
Cdd:TIGR00898 444 RNLGVGVCSTMARVGSIISPFLVYLGEKWLFLPLVLFGGLALLAGILTLFLPETKGVPLPET 505
 
Name Accession Description Interval E-value
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
 2-303 3.77e-137

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 399.01  E-value: 3.77e-137
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974975    2 LSKSVRIIFATLGvCIFFAFGFMVLPLFAYFIREWRRLLLAITLPGVLCGALWWFIPESPRWLISQGRIKEAEVIIRKAA 81
Cdd:TIGR00898 209 LPKKQRAIVGTLI-QVFFSLGLVLLPLVAYFIPDWRWLQLAVSLPTFLFFLLSWFVPESPRWLISQGRIEEALKILQRIA 287

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974975   82 KINGIVAPSTIFDPSETnklQDDSSKKPQsHHIYDLVRTPNIRILTIMSIILWLTISVGYFGLSLDTPNLNGNIYVNCFL 161
Cdd:TIGR00898 288 KINGKKLPAEVLSLSLE---KDLSSSKKQ-YSFLDLFRTPNLRKTTLCLMMLWFTTAFSYYGLVLDLGNLGGNIYLDLFI 363

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974975  162 LAAVEVPAYVLAWLLLQHVSRRYSMAGSLFLGGSVLLLVQLVPSDLHYLSTTLVMVGKFGITSAYSMVYVYTAELYPTVV 241
Cdd:TIGR00898 364 SGLVELPAKLITLLLIDRLGRRYTMAASLLLAGVALLLLLFVPVDLYFLRTALAVLGKFGITSAFQMVYLYTAELYPTVV 443

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568974975  242 RNMGVGVSSTASRLGSILSPYFVYLGAYDRRLPYILMGSLTILTAIITLFFPESSGVSLPET 303
Cdd:TIGR00898 444 RNLGVGVCSTMARVGSIISPFLVYLGEKWLFLPLVLFGGLALLAGILTLFLPETKGVPLPET 505
MFS_SLC22A4_5_OCTN1_2 cd17376
Solute carrier family 22 members 4 and 5 (also called Organic cation/carnitine transporters 1 ...
 1-293 7.28e-118

Solute carrier family 22 members 4 and 5 (also called Organic cation/carnitine transporters 1 and 2) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 22 members 4 (SLC22A4) and 5 (SLC22A5), and similar proteins. SLC22A4 is also called ergothioneine transporter (ETT) or organic cation/carnitine transporter 1 (OCTN1). It is a sodium-ion dependent, low affinity carnitine transporter, and a highly specific transporter for the uptake of ergothioneine (ET), a thiolated derivative of histidine with antioxidant properties. ET is a natural compound produced only by certain fungi and bacteria and must be absorbed from the diet by humans and other vetebrates. SLC22A5, also called organic cation/carnitine transporter 2 (OCTN2), is a sodium-ion dependent, high affinity carnitine transporter involved in the active cellular uptake of carnitine. SLC22A4/5 belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340934 [Multi-domain]  Cd Length: 342  Bit Score: 344.06  E-value: 7.28e-118
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974975   1 MLSKSVRIIFATLGVCIFFAFGFMVLPLFAYFIREWRRLLLAITLPGVLCGALWWFIPesprwlisqgrikeaeviirka 80
Cdd:cd17376  116 ILGKSVRILFSTLGVCIFYAIGYMLLPLFAYFIRDWRMLLLALTLPGVLCVPLWWFIP---------------------- 173

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974975  81 akingivapstifdpsetnklqddsskkpqshhiydlvrtpnirILTIMSIILWLTISVGYFGLSLDTPNLNGNIYVNCF 160
Cdd:cd17376  174 --------------------------------------------ITTIMSLLLWMAISVGYFGLSLNTPNLHGDPYLNCF 209

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974975 161 LLAAVEVPAYVLAWLLLQHVSRRYSMAGSLFLGGSVLLLVQLVPSDLHYLSTTLVMVGKFGITSAYSMVYVYTAELYPTV 240
Cdd:cd17376  210 LSAVIEVPAYIIAWLLLRSLPRRYSIAATLVLGGGVLLFIQLVPTDLQVLATALVMLGKFGITAAFSMVYVYTAELYPTV 289

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 568974975 241 VRNMGVGVSSTASRLGSILSPYFVYLGAYDRRLPYILMGSLTILTAIITLFFP 293
Cdd:cd17376  290 VRNMGVGVCSTASRIGSIISPYFVYLGAYDRYLPYILMGSLTVLIGILTLFLP 342
Sugar_tr pfam00083
Sugar (and other) transporter;
17-307 2.49e-16

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 79.62  E-value: 2.49e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974975   17 IFFAFGFMVLPLFAYFIREWRRLLLAITLPGVLCGALWWFIPESPRWLISQGRIKEAEviiRKAAKINGIVAPSTIFDPS 96
Cdd:pfam00083 151 ILLAYIFGLGLNKTSNSDGWRIPLGLQLVPALLLIIGLLFLPESPRWLVEKGRLEEAR---EVLAKLRGVPDVDRELDEI 227

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974975   97 etnKLQDDSSKKPQSHHIYDLVRTPNIRILTIMSIILWLTI------SVGYFGLSL-DTPNLNGNIYVNcFLLAAVEVPA 169
Cdd:pfam00083 228 ---KDSLEAGQEAEKASWKELFSTKTRRQRLLIGVMLQIFQqltginAIFYYSTTIfENLGLSDSFLVT-IIVGVVNFVF 303

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974975  170 YVLAWLLLQHVSRRY-------SMAG-SLFLGGSVLLLVQLVPSdLHYLSTT--LVMVGKFGITSAySMVYVYTAELYPT 239
Cdd:pfam00083 304 TFIAIFLVDRFGRRPllllgaaGMAIcFVILGIVALLGVSKSDW-AGIVAIVfiALFIAFFAMGWG-PVPWVIVSELFPL 381

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568974975  240 VVRNMGVGVSSTASRLGSILSPYF--VYLGAYDRRLPYILMGSLTILTAIITLFF-PESSGVSLpETIDEM 307
Cdd:pfam00083 382 SVRSKAMALATAANWLANFLIGFLfpIITDAIGLGYTFFIFAGLLVLFIIFVFFFvPETKGRTL-EEIDEL 451
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
182-293 7.45e-08

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 53.34  E-value: 7.45e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974975 182 RRYSMAGSLFLGGSVLLLVQLVPSdlHYLSTTLVMVGKFGITSAYSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSP 261
Cdd:COG2271  247 RKLVLAIGLLLAALALLLLALLPS--PALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGP 324

                         90       100       110
                 ....*....|....*....|....*....|....
gi 568974975 262 YFV--YLGAYDRRLPYILMGSLTILTAIITLFFP 293
Cdd:COG2271  325 LLVgyLLDATGYQAAFLLLAALALLAALLALLLL 358
xylE PRK10077
D-xylose transporter XylE; Provisional
 21-85 2.58e-06

D-xylose transporter XylE; Provisional


Pssm-ID: 182225 [Multi-domain]  Cd Length: 479  Bit Score: 48.92  E-value: 2.58e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568974975  21 FGFMVLPLFAYFIRE-----------WRRLLLAITLPGVLCGALWWFIPESPRWLISQGRIKEAEVIIRkaaKING 85
Cdd:PRK10077 167 FGQLVVYFVNYFIARsgdaswlntdgWRYMFASEAIPALLFLMLLYFVPETPRYLMSRGKQEQAEGILR---KIMG 239
 
Name Accession Description Interval E-value
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
 2-303 3.77e-137

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 399.01  E-value: 3.77e-137
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974975    2 LSKSVRIIFATLGvCIFFAFGFMVLPLFAYFIREWRRLLLAITLPGVLCGALWWFIPESPRWLISQGRIKEAEVIIRKAA 81
Cdd:TIGR00898 209 LPKKQRAIVGTLI-QVFFSLGLVLLPLVAYFIPDWRWLQLAVSLPTFLFFLLSWFVPESPRWLISQGRIEEALKILQRIA 287

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974975   82 KINGIVAPSTIFDPSETnklQDDSSKKPQsHHIYDLVRTPNIRILTIMSIILWLTISVGYFGLSLDTPNLNGNIYVNCFL 161
Cdd:TIGR00898 288 KINGKKLPAEVLSLSLE---KDLSSSKKQ-YSFLDLFRTPNLRKTTLCLMMLWFTTAFSYYGLVLDLGNLGGNIYLDLFI 363

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974975  162 LAAVEVPAYVLAWLLLQHVSRRYSMAGSLFLGGSVLLLVQLVPSDLHYLSTTLVMVGKFGITSAYSMVYVYTAELYPTVV 241
Cdd:TIGR00898 364 SGLVELPAKLITLLLIDRLGRRYTMAASLLLAGVALLLLLFVPVDLYFLRTALAVLGKFGITSAFQMVYLYTAELYPTVV 443

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568974975  242 RNMGVGVSSTASRLGSILSPYFVYLGAYDRRLPYILMGSLTILTAIITLFFPESSGVSLPET 303
Cdd:TIGR00898 444 RNLGVGVCSTMARVGSIISPFLVYLGEKWLFLPLVLFGGLALLAGILTLFLPETKGVPLPET 505
MFS_SLC22A4_5_OCTN1_2 cd17376
Solute carrier family 22 members 4 and 5 (also called Organic cation/carnitine transporters 1 ...
 1-293 7.28e-118

Solute carrier family 22 members 4 and 5 (also called Organic cation/carnitine transporters 1 and 2) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 22 members 4 (SLC22A4) and 5 (SLC22A5), and similar proteins. SLC22A4 is also called ergothioneine transporter (ETT) or organic cation/carnitine transporter 1 (OCTN1). It is a sodium-ion dependent, low affinity carnitine transporter, and a highly specific transporter for the uptake of ergothioneine (ET), a thiolated derivative of histidine with antioxidant properties. ET is a natural compound produced only by certain fungi and bacteria and must be absorbed from the diet by humans and other vetebrates. SLC22A5, also called organic cation/carnitine transporter 2 (OCTN2), is a sodium-ion dependent, high affinity carnitine transporter involved in the active cellular uptake of carnitine. SLC22A4/5 belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340934 [Multi-domain]  Cd Length: 342  Bit Score: 344.06  E-value: 7.28e-118
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974975   1 MLSKSVRIIFATLGVCIFFAFGFMVLPLFAYFIREWRRLLLAITLPGVLCGALWWFIPesprwlisqgrikeaeviirka 80
Cdd:cd17376  116 ILGKSVRILFSTLGVCIFYAIGYMLLPLFAYFIRDWRMLLLALTLPGVLCVPLWWFIP---------------------- 173

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974975  81 akingivapstifdpsetnklqddsskkpqshhiydlvrtpnirILTIMSIILWLTISVGYFGLSLDTPNLNGNIYVNCF 160
Cdd:cd17376  174 --------------------------------------------ITTIMSLLLWMAISVGYFGLSLNTPNLHGDPYLNCF 209

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974975 161 LLAAVEVPAYVLAWLLLQHVSRRYSMAGSLFLGGSVLLLVQLVPSDLHYLSTTLVMVGKFGITSAYSMVYVYTAELYPTV 240
Cdd:cd17376  210 LSAVIEVPAYIIAWLLLRSLPRRYSIAATLVLGGGVLLFIQLVPTDLQVLATALVMLGKFGITAAFSMVYVYTAELYPTV 289

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 568974975 241 VRNMGVGVSSTASRLGSILSPYFVYLGAYDRRLPYILMGSLTILTAIITLFFP 293
Cdd:cd17376  290 VRNMGVGVCSTASRIGSIISPYFVYLGAYDRYLPYILMGSLTVLIGILTLFLP 342
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
 9-293 1.13e-72

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 228.23  E-value: 1.13e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974975   9 IFATLGVCIFFAFGFMVLPLFAYFIREWRRLLLAITLPGVLCGALWWFIPesprwlisqgrikeaeviirkaakingiva 88
Cdd:cd17317  113 SFVGILFGLFWALGYMLLALLAYLIRDWRWLQLAISLPGLLFLLLLWWLP------------------------------ 162

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974975  89 pstifdpsetnklqddsskkpqshhiydlvrtpnirILTIMSIILWLTISVGYFGLSLDTPNLNGNIYVNCFLLAAVEVP 168
Cdd:cd17317  163 ------------------------------------RRTIIVGLIWFVTSLVYYGLSLNSSNLGGNLYLNFFLSGLVEIP 206

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974975 169 AYVLAWLLLQHVSRRYSMAGSLFLGGSVLLLVQLVPSDLHYLSTTLVMVGKFGITSAYSMVYVYTAELYPTVVRNMGVGV 248
Cdd:cd17317  207 AYFLALLLLDRLGRRWTLSGSLLLAGLACLVTALLPDDENTLALTLALVGKFAISAAFSVIYLYTAELYPTVVRNTGVGL 286

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 568974975 249 SSTASRLGSILSPYFVYLGAYDRRLPYILMGSLTILTAIITLFFP 293
Cdd:cd17317  287 CSTVARVGAILAPFIVLLGKIGPLLPLIIFGVLALLGGLLTLLLP 331
MFS_OAT cd17374
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ...
 7-293 3.29e-47

Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340932 [Multi-domain]  Cd Length: 341  Bit Score: 162.85  E-value: 3.29e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974975   7 RIIFATLGVCiFFAFGFMVLPLFAYFIREWRRLLLAITLPGVLCGALWWFIPesprwlisqgrikeaeviirkaakingi 86
Cdd:cd17374  122 RALAITLTSC-FFSIGQMLLAGLAYAIRDWRLLQLVVSVPFFLFFLYSWWLP---------------------------- 172

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974975  87 vapstifdpsetnklqddsskkpqshhiydlvrtpniRILTIMSIIlWLTISVGYFGLSLDTPNLNGNIYVNCFLLAAVE 166
Cdd:cd17374  173 -------------------------------------KRTLILSFV-WFANSFSYYGLSLDLQHLGLNVFLLQFLFGAVE 214

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974975 167 VPAYVLAWLLLQHVSRRYSMAGSLFLGGSVLLLVQLVPSDLHYLSTTLVMVGKFGITSAYSMVYVYTAELYPTVVRNMGV 246
Cdd:cd17374  215 VPARCLALFLLNHMGRRISQAVLLLLAGLCILANIFVPQEMQTLRTVLAVLGKGSSAAAFTISYVYTAELFPTVLRQTGM 294

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 568974975 247 GVSSTASRLGSILSPYFVYLGAYDRRLPYILMGSLTILTAIITLFFP 293
Cdd:cd17374  295 GLNSMFARIGGILAPLIMLLGVYSPLLPMIIYGVLPILAGLLALLLP 341
MFS_SLC22A16_CT2 cd17375
Solute carrier family 22 member 16 (also called Carnitine transporter 2) of the Major ...
 127-293 4.81e-41

Solute carrier family 22 member 16 (also called Carnitine transporter 2) of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 16 (SLC22A16) is also called carnitine transporter 2 (CT2), fly-like putative transporter 2 (FLIPT2), organic cation transporter OKB1, or organic cation/carnitine transporter 6 (OCT6). It is a partially sodium-ion dependent high affinity carnitine transporter. It also transports organic cations such as tetraethylammonium (TEA) and doxorubicin. It is one of several organic cation transporters (OCTs) that falls into the SLC22 (solute carrier 22) family. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. SLC22A16 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340933 [Multi-domain]  Cd Length: 341  Bit Score: 146.43  E-value: 4.81e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974975 127 TIMSIILWLTISVGYFGLSLDTPNLNGNIYVNCFLLAAVEVPAYVLAWLLLQHVSRRYSMAGSLFLGGSVLLLVQLVPSD 206
Cdd:cd17375  175 TITVWLIWFTGSLGYYVFSLGSVNLGGNEYLNLFLVGAVEIPSYIIACIGMDKLGRRNTLAPFLLLSALACMLIMVIPQD 254

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974975 207 LHYLSTTLVMVGKFGITSAYSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFVYLGAYDRRLPYILMGSLTILTA 286
Cdd:cd17375  255 YEVLTIVLSMTGKFAIAIAFGLIYLYTAELYPTIVRSLAVGSGSMMCRVGSVVAPFCVYLSDVWIFLPQLLVGIMAFLSG 334


                 ....*..
gi 568974975 287 IITLFFP 293
Cdd:cd17375  335 ILTLMLP 341
MFS_SLC22A1_2_3 cd17379
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ...
 17-293 2.93e-38

Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340937 [Multi-domain]  Cd Length: 340  Bit Score: 139.02  E-value: 2.93e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974975  17 IFFAFGFMVLPLFAYFIREWRRLLLAITLPGVLCGALWWFIPESprwlisqgrikeaeviirkaakingivapstifdps 96
Cdd:cd17379  129 MFFTLGLLILPGIAYFIPHWRWLQLAVTLPNFLFLLYYWFIPKH------------------------------------ 172

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974975  97 etnklqddsskkpqshhiydlvrtpnirilTIMSIILWLTISVGYFGLSLDTPNLNGNIYVNCFLLAAVEVPAYVLAWLL 176
Cdd:cd17379  173 ------------------------------TFILMYAWFTSAVVYQGLIMRLGITGGNLYLDFFISALVELPAAFIILLT 222

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974975 177 LQHVSRRYSMAGSLFLGGSVLLLVQLVPSDLHYLSTTLVMVGKFGITSAYSMVYVYTAELYPTVVRNMGVGVSSTASRLG 256
Cdd:cd17379  223 IDRIGRRLPFAASNIVAGAACLITAFIPPDLHWLKTTIACVGRLGITMAFEIVCLVNTELYPTFLRNLGVSVCSSLCDIG 302

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 568974975 257 SILSPYFVY-LGAYDRRLPYILMGSLTILTAIITLFFP 293
Cdd:cd17379  303 GIIAPFLLYrLAEIWLELPLIVFGVLALVAGGLVLLLP 340
MFS_SLC22A15 cd17377
Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; ...
 17-293 3.46e-37

Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 15 (SLC22A15) is also called fly-like putative transporter 1 (FLIPT1). It is expressed at the highest levels in the kidney and brain. It is a member of the SLC22 family of transporters, which includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A15 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340935 [Multi-domain]  Cd Length: 353  Bit Score: 136.45  E-value: 3.46e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974975  17 IFFAFGFMVLPLFAYFIREWRRLLLAITLPGVLCGALWWFIPesprwlisqGRikeaeviirkaakingivapstifdps 96
Cdd:cd17377  135 LFFAVGIAQYALLGYFIRSWRTLAVVVNLQGTLVFLLSLFIP---------GR--------------------------- 178

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974975  97 etnklqddsskkpqshhiydlvrtpnirilTIMSIILWLTISVGYFGLSLDTPNLNGNIYVNCFLLAAVEVPAYVLAWLL 176
Cdd:cd17377  179 ------------------------------TLILMYVWFVCSLVYYGLTLNAGDLGGNIYLNLALSGLVELPAYPLCIYL 228

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974975 177 LQH--VSRRYSMAGSLFLGGSVLLLVQLVP--SDLHYL----STTLVMVGKFGITSAYSMVYVYTAELYPTVVRNMGVGV 248
Cdd:cd17377  229 INQkwSGRRRTLAGFLFLGGIACLLVMFVPekKDSGVFavvnSTSLSLLGKLTISAAFNIVYIYTSELYPTVVRNAGLGV 308

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 568974975 249 SSTASRLGSILSPYFVYLGAYDRRLPYILMGSLTILTAIITLFFP 293
Cdd:cd17377  309 CSMFSRVGGIIAPFIPSLKSVQWSLPFIVFGASGLSAGLLSLLLP 353
MFS_SLC22A7_OAT2 cd17447
Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major ...
 10-293 1.31e-35

Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 7 (SLC22A7), also called organic anion transporter 2 (OAT2) mediates sodium-independent transport of a variety of organic anions including prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate, allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha-ketoglutarate. It also plays a role in renal uric acid uptake from blood as a first step of tubular secretion. OAT2 belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS)of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341005 [Multi-domain]  Cd Length: 341  Bit Score: 132.16  E-value: 1.31e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974975  10 FATLGVCIFFAFGFMVLPLFAYFIREWRRLLLAITLPGVLCGALWWFIPEsprwlisqgrikeaeviirkaakingivap 89
Cdd:cd17447  124 VAGVLISLFWTVGNMLLALVAYLIRDWRWLILAVTLPCAPGIITWWWVPK------------------------------ 173

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974975  90 stifdpsetnklqddsskkpqshhiydlvrtpniriLTIMSIILWLTISVGYFGLSLDTPNLNGNIYVNCFLLAAVEVPA 169
Cdd:cd17447  174 ------------------------------------ISLCTGIVWFGVAFTYYGISFNISGFGLNVYLTQFIYGAIELPA 217

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974975 170 YVLAWLLLQHVSRRYSMAGSLFLGGSVLLLVQLVPSDLHYLSTTLVMVGKFGITSAYSMVYVYTAELYPTVVRNMGVGVS 249
Cdd:cd17447  218 KLLAYLLLDRIGRRLTQAGSLILTGLSIGINILIPSEFTVVRTVIAVLGKGFSEAAFTTVFLYTSELYPTVLRQNGMGYT 297

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 568974975 250 STASRLGSILSPYFVYLGAYDRRLPYILMGSLTILTAIITLFFP 293
Cdd:cd17447  298 SFIARLGGSLAPLVILLDDVWLSLPQVIFCGVALLAGGVAFLLP 341
MFS_SLC22A6_OAT1_like cd17446
Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar ...
 6-293 6.66e-34

Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar transporters of the Major Facilitator Superfamily; This subfamily includes solute carrier family 22 member 6 (SLC22A6, also called organic anion transporter 1 or OAT1 or para-aminohippurate (PAH) transporter), SLC22A8 (or OAT3), and SLC22A20 (or OAT6). OAT1 and OAT3 are involved in the renal elimination of endogenous and exogenous organic anions (OAs). They function as OA exchangers, coupling the uptake of OAs against an electrochemical gradient with the efflux of intracellular dicarboxylates. SLC22A20 is an OA transporter that mediates the uptake of estrone sulfate. The OAT1-like subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341004 [Multi-domain]  Cd Length: 339  Bit Score: 127.53  E-value: 6.66e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974975   6 VRIIFATL-GVCifFAFGFMVLPLFAYFIREWRRLLLAITLPGVLCGALWWFIPEsprwlisqgrikeaeviirkaakin 84
Cdd:cd17446  119 VRAVVGTLlGYC--YTLGQLILAGVAYAIRDWRWLQLAVSLPFFIFFLYSWWFPR------------------------- 171

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974975  85 givapstifdpsetnklqddsskkpqshhiydlvrtpniriLTIMSIILWLTISVGYFGLSLDTPNLNGNIYVNCFLLAA 164
Cdd:cd17446  172 -----------------------------------------ITFCLSLVWFSTSFAYYGLAMDLQKFGVSIYLIQIIFGA 210

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974975 165 VEVPAYVLAWLLLQHVSRRYSMAGSLFLGGSVLLLVQLVPSDLHYLSTTLVMVGKFGITSAYSMVYVYTAELYPTVVRNM 244
Cdd:cd17446  211 VDIPAKFISTLTMSYLGRRPTQAAALILAGIMILANIFVPQDLQTVRTALAVFGKGCLAASFNCVYLYTGELYPTVIRQT 290

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 568974975 245 GVGVSSTASRLGSILSPYFVYLGAYDRRLPYILMGSLTILTAIITLFFP 293
Cdd:cd17446  291 GMGLGSTMARLGGIVAPLVKMLGEYYPFLPLIIYGAAPILSGIAACFLP 339
MFS_OCT_plant cd17378
Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of ...
 18-293 3.12e-31

Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of transporters; Plant organic cation/carnitine transporters (OCTs) are sequence-similar to their animal counterparts, which are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. Little is know about plant OCTs. In Arabidopsis, there are six genes belonging to this family that show distinct, organ-specific expression pattern of the individual genes. AtOCT1 has been found to affect root development and carnitine-related responses in Arabidopsis. AtOCT4, 5 and 6 are up-regulated during drought stress, AtOCT3 and 5 during cold stress and AtOCT5 and 6 during salt stress treatments. Plant OCTs belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340936 [Multi-domain]  Cd Length: 342  Bit Score: 120.54  E-value: 3.12e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974975  18 FFAFGFMVLPLFAYFI-REWRRLLLAITLPGVLCGALWWFIPEsprwlisqgrikeaeviirkaakingivapstifdps 96
Cdd:cd17378  131 FFVLGFMSLPGIAYLNgSSWRVLYFWTSIPALIYCILVYLFAR------------------------------------- 173

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974975  97 etnklqddsskkpqshhiydlvrtpniRILTIMsiILWLTISVGYFGLSLDTPNLNGNIYVNCFLLAAVEVPAYVLAWLL 176
Cdd:cd17378  174 ---------------------------RLLAVM--VIGFGIGMVYYGIPLAVGNLKFNIYLSVALNALSELPAFVITAFL 224

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974975 177 LQHVSRRYSMAGSLFLGGSVLLLVQLVPSDLH-YLSTTLVMVGKFGITSAYSMVYVYTAELYPTVVRNMGVGVSSTASRL 255
Cdd:cd17378  225 LDRFGRRPSLLGFTLLSGASCLLCFVLSIGGTtSLQIALELVGFFGAAGAFNLLYIYTVELFPTCVRNAALGMLRQALVV 304

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 568974975 256 GSILSPYFVYLGAYDRRLPYILMGSLTILTAIITLFFP 293
Cdd:cd17378  305 GGIFAPFIVSLGRKNAALSFGVFGVAILLLGLFALGLP 342
Sugar_tr pfam00083
Sugar (and other) transporter;
17-307 2.49e-16

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 79.62  E-value: 2.49e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974975   17 IFFAFGFMVLPLFAYFIREWRRLLLAITLPGVLCGALWWFIPESPRWLISQGRIKEAEviiRKAAKINGIVAPSTIFDPS 96
Cdd:pfam00083 151 ILLAYIFGLGLNKTSNSDGWRIPLGLQLVPALLLIIGLLFLPESPRWLVEKGRLEEAR---EVLAKLRGVPDVDRELDEI 227

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974975   97 etnKLQDDSSKKPQSHHIYDLVRTPNIRILTIMSIILWLTI------SVGYFGLSL-DTPNLNGNIYVNcFLLAAVEVPA 169
Cdd:pfam00083 228 ---KDSLEAGQEAEKASWKELFSTKTRRQRLLIGVMLQIFQqltginAIFYYSTTIfENLGLSDSFLVT-IIVGVVNFVF 303

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974975  170 YVLAWLLLQHVSRRY-------SMAG-SLFLGGSVLLLVQLVPSdLHYLSTT--LVMVGKFGITSAySMVYVYTAELYPT 239
Cdd:pfam00083 304 TFIAIFLVDRFGRRPllllgaaGMAIcFVILGIVALLGVSKSDW-AGIVAIVfiALFIAFFAMGWG-PVPWVIVSELFPL 381

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568974975  240 VVRNMGVGVSSTASRLGSILSPYF--VYLGAYDRRLPYILMGSLTILTAIITLFF-PESSGVSLpETIDEM 307
Cdd:pfam00083 382 SVRSKAMALATAANWLANFLIGFLfpIITDAIGLGYTFFIFAGLLVLFIIFVFFFvPETKGRTL-EEIDEL 451
SP TIGR00879
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ...
 5-303 3.53e-16

MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273317 [Multi-domain]  Cd Length: 481  Bit Score: 79.31  E-value: 3.53e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974975    5 SVRIIFATLGvcIFFAFGFMVLPLFAYFIREWRRLLLAITLPGVLCGALWWFIPESPRWLISQGRIKEAEVIIRKAAKiN 84
Cdd:TIGR00879 166 SLYQLAITFG--ILVAYGFGSGKVSLNNTLGWRIPLGLQLIPAGLLFLGLFFLPESPRWLVGKGRVEEARKSLARLRG-T 242

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974975   85 GIVAPS--TIFDPSETNKLQDDSSKKPQSHHIYDLVRTPNIRILTI--MSIILWLT-ISVGYF---------GLSLDTPn 150
Cdd:TIGR00879 243 SGEDKEllDELELIDIKRSIEKRSVQPSWGSLFSSTRRIRRRLFLGvvLQWFQQFTgINAIMYysptifenaGVSTDHA- 321

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974975  151 lngniYVNCFLLAAVEVPAYVLAWLLLQHVSRR--------YSMAGSLFLGGSVLLLVQLVPSDLHYLSTTLVMVGKFGI 222
Cdd:TIGR00879 322 -----FLVSIIVGAVNFAFTFVAIFLVDRFGRRpllligaaGMAICLFVLGILGASFVTGSSKSSGNVAIVFILLFIAFF 396

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974975  223 -TSAYSMVYVYTAELYPTVVRNMGVGVSSTASRLGSIL-SPYFVY-LGAYDRRLPYILMGSLTILTAIITLFF-PESSGV 298
Cdd:TIGR00879 397 aMGWGPVPWVIVSEIFPLSLRPKGISIAVAANWLANFIvGFLFPTmLESIGVGGVFIFFGGLNVLGLIFVYFFlPETKGR 476


                  ....*
gi 568974975  299 SLPET 303
Cdd:TIGR00879 477 TLEEI 481
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 123-291 1.85e-15

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 76.49  E-value: 1.85e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974975 123 IRILTIMSIILWLTISVGYFGLSLDTPNL--------NGNIYVNCFLLAAVEVPAYVLAWLLLQHVSRRYSMAGSLFLGG 194
Cdd:cd17316  175 LRRRTLLLILLWFFISFGYYGLTTFLPTYlqtvlglsPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSG 254

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974975 195 SVLLLVQLVPSDLHYLSTTLVMVGKFGITSAYSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFV--YLGAYDRR 272
Cdd:cd17316  255 ILALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIalLLASTGGT 334

                        170
                 ....*....|....*....
gi 568974975 273 LPYILMGSLTILTAIITLF 291
Cdd:cd17316  335 GVPALILALLAIVALIVAL 353
MFS_SVOP_like cd17372
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ...
 127-292 1.21e-10

Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340930 [Multi-domain]  Cd Length: 367  Bit Score: 62.17  E-value: 1.21e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974975 127 TIMSIILWLTISVGYFGLSLDTPNLN--GNI-------------------------YVNCFLLAAVEVPAYVLAWLLLQH 179
Cdd:cd17372  176 TLLLWVIWFGNAFAYYGVVLLTTELNnsHNVcgsksdsdsgesptekqcrnsndvdYRDVFIATFAEFPGLLISAAMIDR 255

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974975 180 VSRRYSMAGSLFLGGSVLLLVQLVPSdlHYLSTTLVMVGKFGITSAYSMVYVYTAELYPTVVRNMGVGVSSTASRLGSIL 259
Cdd:cd17372  256 LGRKASMASMLFTCCIFLLLLLICQS--PFILTVLLFGGRACISAAFTVVYIYTPEVYPTAVRALGVGTGSSVGRIGAIL 333

                        170       180       190
                 ....*....|....*....|....*....|...
gi 568974975 260 SPYFVYLGAYDRRLPYILMGSLTILTAIITLFF 292
Cdd:cd17372  334 CPFIAQVLVHGSQTIALLLFSVVCLVSAICVCL 366
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 12-261 8.43e-10

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 59.68  E-value: 8.43e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974975   12 TLGVCIFFAFGFMVLPLFAyfireWRRL-LLAITLPGVLCGALWWFIPESPRWLISQGRikeaeviiRKAAKINGIVAPS 90
Cdd:TIGR00895 151 PIGAAVGGFLAGWLIPVFG-----WRSLfYVGGIAPLLLLLLLMRFLPESIDFLVSKRP--------ETVRRIVNAIAPQ 217

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974975   91 TIFDPSETnkLQDDSSKKPQSHHIYDLVRTPnirILTIMSIILWLTIS---VGYFGLSLDTPNL----NGNIYVNCFLLA 163
Cdd:TIGR00895 218 MQAEAQSA--LPEQKSTQGTKRSVFKALFQG---KTARITVLLWLLYFmllVGVYFLTNWLPKLmvelGFSLSLAATGGA 292

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974975  164 AVEVPAYVLAWL---LLQHVSRRYSMAGSLFLGGSVLLLVQLVPSDLHYLsTTLVMVGKFgITSAYSMVYVYTAELYPTV 240
Cdd:TIGR00895 293 LFNFGGVIGSIIfgwLADRLGPRVTALLLLLGAVFAVLVGSTLFSPTLLL-LLGAIAGFF-VNGGQSGLYALMALFYPTA 370

                         250       260
                  ....*....|....*....|.
gi 568974975  241 VRNMGVGVSSTASRLGSILSP 261
Cdd:TIGR00895 371 IRATGVGWAIGIGRLGAIIGP 391
MFS_GLUT_Class1_2_like cd17357
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ...
 16-303 1.11e-09

Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340915 [Multi-domain]  Cd Length: 447  Bit Score: 59.20  E-value: 1.11e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974975  16 CIFFAFGFMVLPLFAY-FI----REWRRLLLAITLPGVLCGALWWFIPESPRWL-ISQGRIKEAEVIIRKAAKINGIVAP 89
Cdd:cd17357  147 QIGVTLGILLGQVFGLpSVlgteTLWPYLLFFPGIPALLQLAALPFFPESPKFLlISKGDEEEAEKSLKFLRGIEDDVDQ 226

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974975  90 STifdpsETNKLQDDSSKKPQSHHIYDLVRTPNIRILTIMSIILWLTI-----------SVGYF---GLSLDTPnlngnI 155
Cdd:cd17357  227 EL-----EEIKKESEQMGDQKQVSLMQLLRDPSLRLPLLLVLVVSASQqfsginaiffySTFIFenaGFSPQLA-----E 296

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974975 156 YVNcFLLAAVEVPAYVLAWLLLQHVSRRYSMAGSLFL--GGSVLLLVQLVPSDLHYLSTTLVMVGKFGITSAYSMV---- 229
Cdd:cd17357  297 WAN-LGIGIVNVLSTIVGPFLIEKVGRRPLLLISLSVcaVALLLMSVFLFLSEQNSWMSYGCIVAIFLFIFFFAIGlgpi 375

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568974975 230 -YVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFVYLgaydrrLPYILMGSLTILTAIITLFFPESSGVSLPET 303
Cdd:cd17357  376 pWFIGAELFPQAPRSAAQSLGSSVNWTSNFIVGMAFPP------LQSIGGGFVFIIFAIPCALFLLYLYRYLPET 444
MFS_GLUT6_8_Class3_like cd17358
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ...
 9-302 2.60e-09

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340916 [Multi-domain]  Cd Length: 436  Bit Score: 57.97  E-value: 2.60e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974975   9 IFATLGVCIFFAFGFMVlplfayfirEWRRLLLAITLPGVLCGALWWFIPESPRWLISQGRIKEAEVIIRKAAKINGIVA 88
Cdd:cd17358  137 LLVNIGILLGYVLGSFL---------PWRTLALIGAIPPVVFLILLFFIPESPRWLAKKGREEEAEKSLQFLRGKDADIS 207

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974975  89 PSTIFDPSETNKLQDDSSKKPQShhiyDLVRTPNIRILTIMSIILWLTISVGYFGLS------LDTPNLNGNIYVNCFLL 162
Cdd:cd17358  208 KEAAEIQEELAELEKEAKESSFS----DLFQRKYLKPLVIGLGLMLFQQLSGINAVIfyassiFDEAGSGLDPNTATIII 283

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974975 163 AAVEVPAYVLAWLLLQHVSRRYSM--------AGSLFLGGSVLL-LVQLVPSDLHYLSTTLVMVGKFGITSA-YSMVYVY 232
Cdd:cd17358  284 GVVQVVGTLVATLLVDRLGRRPLLlvsaigmgIGLLALGLYFYLqEHGALLSSVSWLPLVGLVIYIISFSIGlGPLPWVI 363

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568974975 233 TAELYPTVVRNMGVGVSSTASRLGSILSPYF-----VYLGAYdrrLPYILMGSLTILTAIITLFF-PESSGVSLPE 302
Cdd:cd17358  364 MSEIFPAKIKGLAGSLVTLVNWLFAFIVTKTfpfltLAWGAS---GTFWIFAGICGLALVFVLLFvPETKGKSLEE 436
MFS_SVOPL cd17442
Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) of the Major Facilitator Superfamily; ...
 175-262 1.93e-08

Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) or SVOP-like protein is a transporter-like protein that shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. It belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341000 [Multi-domain]  Cd Length: 375  Bit Score: 55.20  E-value: 1.93e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974975 175 LLLQHVSRRYSMAGSLFLGGSVLLLVQLVPSDLHYlsTTLVMVGKFGITSAYSMVYVYTAELYPTVVRNMGVGVSSTASR 254
Cdd:cd17442  258 LGINFLGRRLSLVITMGLTAIFFLLLNICTSSAGL--TIFLFMLRALVSANFNTVYIYTAEVYPTTMRALGMGTSGSLCR 335


                 ....*...
gi 568974975 255 LGSILSPY 262
Cdd:cd17442  336 IGAMVAPF 343
MFS_SVOP cd17441
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic ...
 166-293 5.81e-08

Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein (SVOP) is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. This SVOP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340999 [Multi-domain]  Cd Length: 372  Bit Score: 53.66  E-value: 5.81e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974975 166 EVPAYVLAWLLLQHVSRRYSMAGSLFLGGSVLLLVQLVPSdlHYLSTTLVMVGKFGITSAYSMVYVYTAELYPTVVRNMG 245
Cdd:cd17441  246 EFPGLLVTLWIIDRFGRKKTMALCFFVFSFCTLLLFSCVG--RFSLTVLLFIARAFISGGFQAAYVYTPEVYPTATRALG 323

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 568974975 246 VGVSSTASRLGSILSPYFV-YLGAYDRRLPYILMGSLTILTAIITLFFP 293
Cdd:cd17441  324 LGTCSGMARVGALITPFIAqVMLESSVYLTLSVYSGCCLLAAIASCFLP 372
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
182-293 7.45e-08

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 53.34  E-value: 7.45e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974975 182 RRYSMAGSLFLGGSVLLLVQLVPSdlHYLSTTLVMVGKFGITSAYSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSP 261
Cdd:COG2271  247 RKLVLAIGLLLAALALLLLALLPS--PALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGP 324

                         90       100       110
                 ....*....|....*....|....*....|....
gi 568974975 262 YFV--YLGAYDRRLPYILMGSLTILTAIITLFFP 293
Cdd:COG2271  325 LLVgyLLDATGYQAAFLLLAALALLAALLALLLL 358
synapt_SV2 TIGR01299
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ...
 30-194 2.23e-07

synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.


Pssm-ID: 130366 [Multi-domain]  Cd Length: 742  Bit Score: 52.67  E-value: 2.23e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974975   30 AYFIREWRRLLLAITLPGVLCGALWWFIPESPRWLISQGRIKEAEVIIRKAAKIN-----------GIVAPSTIFDPSET 98
Cdd:TIGR01299 327 AYQFHSWRVFVIVCAFPCVFAIGALTFMPESPRFFLENGKHDEAWMILKLIHDTNmrakghpekvfSVNHIKTIHQEDEL 406

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974975   99 NKLQDDSSKKPQSHHIYDLVR------------TPNIRILTIMSIILWLTISVGYFGLSLDTPNLNGNIYVNCFLLAAVE 166
Cdd:TIGR01299 407 IEIESDTGTWYQRCFVRALSEgggiwgnflrcfNPEVREITIKLMGVWFTLSFGYYGLSVWFPDMIKHLQADDYAALTKN 486

                         170       180
                  ....*....|....*....|....*...
gi 568974975  167 VPAYVLAwlllqHVSRRYSMAGSLFLGG 194
Cdd:TIGR01299 487 FPGDKVA-----HFSFNFTLENQIHRGG 509
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 169-261 8.09e-07

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 50.28  E-value: 8.09e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974975 169 AYVLAWLLLqHVSRRYSMAGSLFLGGSVLLLVQLVPSDLHYLSTTLVMVGkFGITSAYSMVYVYTAELYPTVVRNMGVGV 248
Cdd:cd17365  223 SLLLGWLAD-RFGPKRVLALFFALGAVSLALLGVSPASLVLLYVLVFLAG-ACVNGAQVGLYALAARFYPTEVRATGVGW 300

                         90
                 ....*....|...
gi 568974975 249 SSTASRLGSILSP 261
Cdd:cd17365  301 ALGVGRLGAILGP 313
MFS_SV2C cd17440
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; ...
 30-151 1.38e-06

Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2C exhibits enriched expression in several basal ganglia nuclei, and has been found to be involved in normal operation of the basal ganglia network and could be also be involved in system adaptation in basal ganglia pathological conditions. SV2C belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340998 [Multi-domain]  Cd Length: 479  Bit Score: 49.91  E-value: 1.38e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974975  30 AYFIREWRRLLLAITLPGVLCGALWWFIPESPRWLISQGRIKEAEVIIRKAAKINGIV--APSTIFdpsETNKLQDDSsk 107
Cdd:cd17440  159 AYQFHSWRVFVIVCALPCVSSVVALTFMPESPRFLLEVGKHDEAWMILKQIHDTNMRArgQPEKVF---TVNRIKKDN-- 233

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 568974975 108 kpqshhiydlvrtpnirilTIMSIILWLTISVGYFGLSLDTPNL 151
Cdd:cd17440  234 -------------------TIKLTIVWLTLSFGYYGLSVWFPDV 258
MFS_SV2 cd17363
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic ...
 30-295 1.40e-06

Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. The SV2 family belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340921 [Multi-domain]  Cd Length: 474  Bit Score: 49.79  E-value: 1.40e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974975  30 AYFIREWRRLLLAITLPGVLCGALWWFIPESPRWLISQGRIKEAEVIIRKAAKIN--GIVAPSTIFDPSETNklqddssk 107
Cdd:cd17363  159 AYQFHSWRVFVIVCALPSVASVVALTFMPESPRFLLEVGKHDEAWMILKQVHDTNmrAKGHPERVFTVSHIK-------- 230

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974975 108 kpqshhiydlvrtpniRILTIMSIILWLTISVGYFGLS------------------------------------------ 145
Cdd:cd17363  231 ----------------RMNTLFLAIVWFTMSFSYYGLTvwfpdmikylqfedslfeecyfedvtstntffenctfintvf 294

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974975 146 ----------LDTPNLNGN--------------------IYVNCFLLAAVEVPAYVLAWLLLQHVSRRYSMAGSLFLGGS 195
Cdd:cd17363  295 yntdlfeykfIDSRFLNSTfflkekcgchlnddeenaylIYLVSFLGSLSVLPGNIVSALLMDKIGRLKMIGGSMLLSAV 374

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974975 196 VLLLVQLVPSDlhylSTTLVMVGKFGITS--AYSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPY-FVYLGAYDRR 272
Cdd:cd17363  375 CCFFLFFGNSE----SAMIGLQCLFCGVSiaAWNALDVVTVELYPTDKRATAFGFLNGLCKLAAILGNSiFGSFVGITKV 450

                        330       340
                 ....*....|....*....|...
gi 568974975 273 LPYILMGSLTILTAIITLFFPES 295
Cdd:cd17363  451 IPILLASAALVCGGLLALKLPET 473
xylE PRK10077
D-xylose transporter XylE; Provisional
 21-85 2.58e-06

D-xylose transporter XylE; Provisional


Pssm-ID: 182225 [Multi-domain]  Cd Length: 479  Bit Score: 48.92  E-value: 2.58e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568974975  21 FGFMVLPLFAYFIRE-----------WRRLLLAITLPGVLCGALWWFIPESPRWLISQGRIKEAEVIIRkaaKING 85
Cdd:PRK10077 167 FGQLVVYFVNYFIARsgdaswlntdgWRYMFASEAIPALLFLMLLYFVPETPRYLMSRGKQEQAEGILR---KIMG 239
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 9-290 2.98e-06

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 48.58  E-value: 2.98e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974975   9 IFATLGVCIFFAFGFMVLPLFAYFIREWRRLLLAITLPGVLCGALWWFIPESPRWLISQGRIKEaeviirkaakingiva 88
Cdd:cd06174  124 LLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIAAALALLAAILLLLVVPDPPESARAKNEEA---------------- 187

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974975  89 pstifdpsetnklqddsSKKPQSHHIYDLVRTPNIRILTIMSII----------LWLTISVGYFGLSLDTPNLNGNIYVN 158
Cdd:cd06174  188 -----------------SSKSVLKLLKRVLKNPGLWLLLLAIFLvnlayysfstLLPLFLLDLGGLSVAVAGLLLSLFGL 250

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974975 159 CFLLAAVevpayVLAWLLLQHVSRRYSMAGSLFLGGSVLLLVQLVPSdlHYLSTTLVMVGKFGITSAYSMVYVYTAELYP 238
Cdd:cd06174  251 AGALGSL-----LLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPS--LLLLLLLLLLLGFGLGGLLPLSFALIAELFP 323

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 568974975 239 TVVRNMGVGVSSTASRLGSILSPY---FVYLGAYDRRLPYILMGSLTILTAIITL 290
Cdd:cd06174  324 PEIRGTAFGLLNTFGFLGGAIGPLlagFLLAATFGLTGAFLVLAVLLLLAAILLL 378
MFS_XylE_like cd17359
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ...
 36-69 5.34e-05

D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340917 [Multi-domain]  Cd Length: 383  Bit Score: 44.48  E-value: 5.34e-05
                         10        20        30
                 ....*....|....*....|....*....|....
gi 568974975  36 WRRLLLAITLPGVLCGALWWFIPESPRWLISQGR 69
Cdd:cd17359  162 WRWMLGLEAIPAILFLLGMLFIPESPRWLVSKGK 195
MFS_GLUT8_Class3 cd17433
Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of ...
 9-302 6.19e-05

Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 8 (GLUT8) is also called Solute carrier family 2, facilitated glucose transporter member 8 (SLC2A8) or glucose transporter type X1 (GLUTX1). It is classified as a Class 3 GLUT protein and is an insulin-regulated facilitative glucose transporter predominantly expressed in testis and brain. It can also transport fructose and galactose. SLC2A8 knockout mice were viable, developed normally, and display only a very mild phenotype, including mild alterations in the brain (increased proliferation of hippocampal neurons), heart (impaired transmission of electrical wave through the atrium), and sperm cells (reduced number of motile sperm cells). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340991 [Multi-domain]  Cd Length: 416  Bit Score: 44.48  E-value: 6.19e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974975   9 IFATLGVCI--FFAFGFMVLPLFAYFIrEWRRLLLAITLPGVLCGALWWFIPESPRWLISQGRIKEAEVIIRkaaKINGI 86
Cdd:cd17433  127 VRGTLGSCVqlMVVIGIMGAYLAGLVL-DWRWLAVLGSIPPTLMLLLMCFMPETPRFLLTQHRRQEAMAALR---FLRGP 202

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974975  87 VAPSTifdpSETNKLQDDSSKKPQSHHIYDLvRTPNIRILTIMSIILWL------TISVGYFGLSLDTPNLNGNIYVNCF 160
Cdd:cd17433  203 DQGWE----WECIGIEQSFHLEEQSFSLALL-KQPGIYKPLIIGVSLMAfqqltgINAVMFYAETIFEEAKFKDSSVASV 277

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974975 161 LLAAVEVPAYVLAWLLLQHVSRRYsmagSLFLGGSVLLLVQLVPSDLHYLSTTLVMVGkFGITSAySMVYVYTAELYPTV 240
Cdd:cd17433  278 IVAAIQVLFTAVAALIMDRAGRKV----LLVLSGVVMVFSTAAFGWLAVGSMGFFIAG-FAVGWG-PIPWLVMSEIFPLH 351

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568974975 241 VRNMGVG------------VSSTASRLGSILSPYfvylGAydrrlpYILMGSLTILTAIITLFF-PESSGVSLPE 302
Cdd:cd17433  352 VRGVASGicvltnwlmaflVTKEFSSLMEVLSSY----GT------FWLFSAFCAFSVLFTLFCvPETKGKTLEQ 416
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
17-260 8.45e-05

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 43.81  E-value: 8.45e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974975  17 IFFAFGFMVLPLFAYFIRE---WRRLLLAITLPGVLCGAL-WWFIPESPRwlisqgrikeaeviirkaakingivapsti 92
Cdd:COG2814  141 AGLGLGPALGPLLGGLLADlfgWRWVFLVNAVLALLALLLlLRLLPESRP------------------------------ 190

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974975  93 fdpsetnklqddSSKKPQSHHIYDLVRTPNIRILTIMSIILWLTISVGYFGLSL---DTPNLNGNIYVNCFLLAAV-EVP 168
Cdd:COG2814  191 ------------AARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLylqEVLGLSASAAGLLLALFGLgGVL 258

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974975 169 AYVLAWLLLQHVSRRYSMAGSLFLGGSVLLLVQLVPSDLHYLSTTLVMVgkFGITSAYSMVYVYTAELYPTVVRNMGVGV 248
Cdd:COG2814  259 GALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLG--FGFGLLFPLLQALVAELAPPEARGRASGL 336

                        250
                 ....*....|..
gi 568974975 249 SSTASRLGSILS 260
Cdd:COG2814  337 YNSAFFLGGPLA 348
MFS_PhT cd17364
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ...
 161-296 1.10e-04

Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340922 [Multi-domain]  Cd Length: 389  Bit Score: 43.81  E-value: 1.10e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974975 161 LLAAVEVPAYVLAWLLLQHVSRRY-SMAGslFLGGSVLLLVQLVPSDLHYLSTTLVMV--------GKFGitsAYSMVYV 231
Cdd:cd17364  248 IALAGTVPGYWFTVFLIDRIGRKKiQMMG--FFGMTIFLLILAGPYDHWKISTIGFFVlygltfffSNFG---PNTTTFI 322

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568974975 232 YTAELYPTVVRNMGVGVSSTASRLGSILSPY-FVYLGA-YDRRLPYILMGSLTILTAIITLFFPESS 296
Cdd:cd17364  323 VPAEVFPARVRSTCHGISAASGKIGAIVGSFlFLSLTQnIGVRNVLIILAGVALLGIILTLLFPEEK 389
MFS_HXT cd17356
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ...
 217-307 1.64e-04

Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340914 [Multi-domain]  Cd Length: 403  Bit Score: 43.01  E-value: 1.64e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974975 217 VGKFGITSAySMVYVYTAELYPTVVRNMGVGVSSTASRLG----SILSPYFVylGAYDRRLPYILMGSLTILTAIITLFF 292
Cdd:cd17356  312 IFSFATTWG-PIAWVYVAEVFPLRVRSKGMALATAFNWLWnfliSFFTPFII--GSIGFKYYYIFAGCNLLAFIVVFFFV 388

                         90
                 ....*....|....*
gi 568974975 293 PESSGVSLpETIDEM 307
Cdd:cd17356  389 PETKGLTL-EEIDEL 402
MFS_SLC22A17 cd17445
Solute carrier family 22, member 17 of the Major Facilitator Superfamily; Solute carrier ...
 159-293 1.68e-04

Solute carrier family 22, member 17 of the Major Facilitator Superfamily; Solute carrier family 22, member 17 (SLC22A17) is also called 24p3 receptor (24p3R), lipocalin-2 receptor, or neutrophil gelatinase-associated lipocalin (NGAL) receptor (NGALR). It functions as a cell surface receptor for lipocalin-2 (LCN2), also called NGAL or 24p3, which plays a key role in iron homeostasis and transport. LCN2 is a secreted protein of the lipocalin family that induces apoptosis in some types of cells and inhibits bacterial growth by sequestration of the iron-laden bacterial siderophore. Over-expressions of NGAL and NGALR have been found to be correlated with unfavorable clinicopathologic features and poor prognosis of patients with hepatocellular carcinoma. SLC22A17 is a member of the SLC22 family of organic cation/anion/zwitterion transporters, which includes organic cation transporters (OCTs/OCTNs) and organic anion transporters (OATs). It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341003 [Multi-domain]  Cd Length: 346  Bit Score: 42.84  E-value: 1.68e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974975 159 CFLLAaveVPAYVLAWLLLQHVSRRYSMAGSLFL-----GGSVLLLVQLVPSDLHYLSTTLVMVGKFGITSAYSMVYVYT 233
Cdd:cd17445  210 SYLLS---TGTAGLACLFLCATVDRFGRRGILLLamtltGIASLILLGLMDYLNDAAIKTFSILGLFSSQAAASLSILFA 286

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974975 234 AELYPTVVRNMGVGVSSTASRLGSILSPYFVYLGAYDRRLPYILMGSLTILTAIITLFFP 293
Cdd:cd17445  287 AEVIPTVIRGSGLGLIMALGSLGGLSSPLMRLRNQHGYFLHHVVLASLALLAILSIMLLP 346
MFS_SV2A cd17439
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; ...
 30-151 1.93e-04

Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. It is unclear how SV2A is involved in correct SV function, but it has been suggested to either act as a transporter or a regulator of exocytosis by mediating Ca2+ dynamics. SV2A has been identified as the molecular target of the antiepileptic drug levetiracetam (LEV). Its expression is decreased in patients with epilepsy and in epileptic animal models. SV2A belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340997 [Multi-domain]  Cd Length: 478  Bit Score: 43.10  E-value: 1.93e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974975  30 AYFIREWRRLLLAITLPGVLCGALWWFIPESPRWLISQGRIKEAEVIIRKAakingivapstifdpsetnklqDDSSKKP 109
Cdd:cd17439  159 AYQFHSWRVFVLVCAFPSVFAIGALTTMPESPRFFLENGKHDEAWMVLKQV----------------------HDTNMRA 216

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 568974975 110 QSHHIYDLVRTPNIRILTIMSIILWLTISVGYFGLSLDTPNL 151
Cdd:cd17439  217 KGHPERVFSVTHIKRRITLMMMAVWFTMSFSYYGLTVWFPDM 258
synapt_SV2 TIGR01299
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ...
 155-297 2.62e-04

synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.


Pssm-ID: 130366 [Multi-domain]  Cd Length: 742  Bit Score: 42.66  E-value: 2.62e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974975  155 IYVNCFLLAAVEVPAYVLAWLLLQHVSRRYSMAGSLFLGGSVLLLVQLVPSDlhylSTTLVMVGKFG--ITSAYSMVYVY 232
Cdd:TIGR01299 597 IYFVNFLGTLAVLPGNIVSALLMDKIGRLRMLAGSMVLSCISCFFLSFGNSE----SAMIALLCLFGglSIAAWNALDVL 672

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568974975  233 TAELYPTVVRNMGVGVSSTASRLGSILS-PYFVYLGAYDRRLPYILMGSLTILTAIITLFFPESSG 297
Cdd:TIGR01299 673 TVELYPSDKRATAFGFLNALCKAAAVLGiLIFGSFVGITKAAPILFASAALACGGLLALKLPDTRG 738
MFS_SLC22A31 cd17443
Solute carrier family 22, member 31 of the Major Facilitator Superfamily; Solute carrier ...
 156-293 3.99e-04

Solute carrier family 22, member 31 of the Major Facilitator Superfamily; Solute carrier family 22, member 31 (SLC22A31) is an uncharacterized member of the SLC22 family of transporters, which includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A31 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341001 [Multi-domain]  Cd Length: 343  Bit Score: 41.69  E-value: 3.99e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974975 156 YVNCFLLAAVEVPAYVLAWLLLQHVSRR-YSMAGSLFLGGSVLLLVQLVPSDLHYLSTTLVMVGKFGiTSAYSMVYV-YT 233
Cdd:cd17443  205 YLPYFLQAGLEALACIFLCLTVDRCGRRgVLLLGTIVTGLSSLLLLALTQYLHGGLVLVLSVVGLLA-SHAVSMLSMfFA 283

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974975 234 AELYPTVVRNMGVGVSSTASRLGSILSPYFVYLGAYDRRLPYILMGSLTILTAIITLFFP 293
Cdd:cd17443  284 AEVLPTVIRGAGLGLIMGAGFLGRAAGPLMELQNKQGYFLHHVVFASFAVLSVLCILLLP 343
2A0109 TIGR00887
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the ...
 36-302 6.51e-04

phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the major facilitator superfamily (pfam00083). [Transport and binding proteins, Anions]


Pssm-ID: 129965 [Multi-domain]  Cd Length: 502  Bit Score: 41.25  E-value: 6.51e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974975   36 WRRLLLAITLPGvlCGALWW--FIPESPRWLISQGRIKEAEVIIRKAAKINGIVAPSTIFDPSETNKLQDDSSKKPQSHH 113
Cdd:TIGR00887 203 WRILIGFGAVPA--LLALYFrlTIPETPRYTADVAKDVEQAASDMSAVLQVKIEAEPDEVEKASTAVEVPKASWSDFFTH 280

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974975  114 iYDLVRTPNIRILTIMSiilWLTISVGYFGLSLD-----------TPNLNGNIY--------VNCFLLAAVEVPAYVLAW 174
Cdd:TIGR00887 281 -FFKWRHGKHLLGTAGS---WFLLDIAFYGVNLNqkvilsaigysPPAATNNAYeelyktavGNLIIALAGTVPGYWVTV 356

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974975  175 LLLQHVSRRY-SMAGSLFLGgsVLLLVQLVPSD---LHYLSTTLVMVGKFGITSAYSMVYVYTAELYPTVVRNMGVGVSS 250
Cdd:TIGR00887 357 FLVDIIGRKPiQLMGFFILT--VLFFVLGFAYNhlsTHGFLAIYVLAQFFANFGPNATTFIVPGEVFPTRYRSTAHGISA 434

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568974975  251 TASRLGSILSPY-FVYL----GAYDRRLPYILMGSLTILTAII-------TLFFPESSGVSLPE 302
Cdd:TIGR00887 435 ASGKAGAIIGQFgFLYLaqhgDPTKGYPTGIWMGHVLEIFALFmflgilfTLLIPETKGKSLEE 498
MFS_SV2B cd17438
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ...
 31-295 6.53e-04

Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340996 [Multi-domain]  Cd Length: 477  Bit Score: 41.45  E-value: 6.53e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974975  31 YFIREWRRLLLAITLPGVLCGALWWFIPESPRWLISQGRIKEAEVIIRKAAKIN--GIVAPSTIFDPSETNKLQddsskk 108
Cdd:cd17438  160 YHFHSWRVFVIICALPCIASIIALKFMPESPRFLLEMGKHDEAWMILKNIHDTNmrAKGTPEKVFTVSNIKRKN------ 233

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974975 109 pqshhiydlvrtpnirilTIMSIILWLTISVGYFGLSLDTPNL-------------------------NGNIYVNC---- 159
Cdd:cd17438  234 ------------------TLFLAVVWFTMAFSYYGLTVWFPDMirylqkhvtfedslfdecyfedvtsTDTYFKNCties 295

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974975 160 ----------------------------------------------FLLAAVEVPAYVLAWLLLQHVSRRYSMAGSLFLG 193
Cdd:cd17438  296 tifyntdlyehkfidcrfinstfleqkegchmdfeedndfliylvsFLGSLSVLPGNIISALLMDKIGRIKMIGGSMLIS 375

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974975 194 GSVLLLVQLVPSDLHYLSTTLVMVGKfgITSAYSMVYVYTAELYPTVVRNMGVGVSSTASRLGSIL-SPYFVYLGAYDRR 272
Cdd:cd17438  376 AVCCFFLFFGNSESAMIGWQCLFCGT--SIAAWNALDVITVELYPTNKRATAFGILNGLCKFAAILgNSIFASFVGITKV 453

                        330       340
                 ....*....|....*....|...
gi 568974975 273 LPYILMGSLTILTAIITLFFPES 295
Cdd:cd17438  454 IPILLASTALVGGGLISLRLPET 476
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 175-294 1.51e-03

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 39.87  E-value: 1.51e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974975 175 LLLQHVSRRYSMAGSLFLGGSVLLLVQLVPSDLHYLSTTLVMvgkfGITSAYSMV--YVYTAELYPTVVRNMGVGVSSTA 252
Cdd:cd17325   53 RLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQ----GLASAAVWPaaMALIADIAPPEERGRAMGIFSSA 128

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 568974975 253 SRLGSILSPYF--VYLGAYDRRLPYILMGSLTILTAIITLFFPE 294
Cdd:cd17325  129 IGLGFLIGPLLggLLADALGYRAPFLVCAALALLALVLALLLLP 172
MFS_1 pfam07690
Major Facilitator Superfamily;
176-306 2.84e-03

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 39.32  E-value: 2.84e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974975  176 LLQHVSRRYSMAGSLFLGGSVLLLVQLVPSDLhYLSTTLVMVGkFGITSAYSMVYVYTAELYPTVVRNMGVGVSSTASRL 255
Cdd:pfam07690  55 LSDRFGRRRVLLIGLLLFALGLLLLLFASSLW-LLLVLRVLQG-LGAGALFPAALALIADWFPPEERGRALGLVSAGFGL 132

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 568974975  256 GSILSPYFVYL--GAYDRRLPYILMGSLTILTAIITLFFPESSGVSLPETIDE 306
Cdd:pfam07690 133 GAALGPLLGGLlaSLFGWRAAFLILAILSLLAAVLLLLPRPPPESKRPKPAEE 185
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 160-295 7.22e-03

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 37.79  E-value: 7.22e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974975 160 FLLAAVEVPAYVLAWL---LLQHVSRRYSMAGSLFLGGSVLLLVQLVPSDLHYLSTTLVmvGKFGITSAYSMVYVYTAEL 236
Cdd:cd06174   35 LLFALFSLGYALLQPLaglLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLLGRFL--LGLGSGLIDPAVLALIADL 112

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568974975 237 YPTVVRNMGVGVSSTASRLGSILSP----YFVYLGAYDRRLPYILMGSLTILTAIITLFFPES 295
Cdd:cd06174  113 FPERERGRALGLLQAFGSVGGILGPllggILASSLGFGWRAVFLIAAALALLAAILLLLVVPD 175
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 160-292 7.44e-03

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 37.94  E-value: 7.44e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974975 160 FLLAAVevpAYVLAWLLLQHVSRRYSMAGSLFLGGSVLLLVQLVPSdlHYLSTTLVMVGKFGITSAYSMVYVYTAELYPT 239
Cdd:cd17474  245 VLLALG---SLFVGRLLKKRFGARRILVIGLLLYALSLLLLGFVPS--LALLLIAIVLFGLGLGLNLPLLTTLVTELAPE 319

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 568974975 240 VVRNMGVGVSSTASRLGSILSPYF--VYLGAYDRRLPYILMGSLTILTAIITLFF 292
Cdd:cd17474  320 EERGTASSLYNFVRFLGQAVGPLLfgLLLEIFGLSAPFLVGAAIALAAAVLLALL 374
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH