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Conserved domains on  [gi|568920784|ref|XP_006535467|]
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guanine nucleotide-binding protein subunit beta-4 isoform X1 [Mus musculus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 10077586)

WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 8-251 2.38e-66

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 207.19  E-value: 2.38e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920784   8 SSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREgnvrVSRELPGHTGYLSCCRFLDDGQIITSSG-DTTCALWDIETGQ 86
Cdd:cd00200   51 TGPVRDVAASADGTYLASGSSDKTIRLWDLETGE----CVRTLTGHTSYVSSVAFSPDGRILSSSSrDKTIKVWDVETGK 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920784  87 QTTTFTGHSGDVMSLSLSPDlKTFVSGAC-DASSKLWDIRDGMCRQSFTGHISDINAVSFFPSGYAFATGSDDATCRLFD 165
Cdd:cd00200  127 CLTTLRGHTDWVNSVAFSPD-GTFVASSSqDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWD 205

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920784 166 LRADQEL-LLYSHDNIICgitSVAFSKSGRLLLAGYDDFNCSVWDALKGGRSGVLAGHDNRVSCLGVTDDGMAVATGSWD 244
Cdd:cd00200  206 LSTGKCLgTLRGHENGVN---SVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSAD 282


                 ....*..
gi 568920784 245 SFLRIWN 251
Cdd:cd00200  283 GTIRIWD 289
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 8-251 2.38e-66

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 207.19  E-value: 2.38e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920784   8 SSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREgnvrVSRELPGHTGYLSCCRFLDDGQIITSSG-DTTCALWDIETGQ 86
Cdd:cd00200   51 TGPVRDVAASADGTYLASGSSDKTIRLWDLETGE----CVRTLTGHTSYVSSVAFSPDGRILSSSSrDKTIKVWDVETGK 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920784  87 QTTTFTGHSGDVMSLSLSPDlKTFVSGAC-DASSKLWDIRDGMCRQSFTGHISDINAVSFFPSGYAFATGSDDATCRLFD 165
Cdd:cd00200  127 CLTTLRGHTDWVNSVAFSPD-GTFVASSSqDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWD 205

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920784 166 LRADQEL-LLYSHDNIICgitSVAFSKSGRLLLAGYDDFNCSVWDALKGGRSGVLAGHDNRVSCLGVTDDGMAVATGSWD 244
Cdd:cd00200  206 LSTGKCLgTLRGHENGVN---SVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSAD 282


                 ....*..
gi 568920784 245 SFLRIWN 251
Cdd:cd00200  283 GTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
8-251 1.05e-50

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 170.48  E-value: 1.05e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920784   8 SSWVMTCAYAPSGNYVACGGLDNICSIYNLKTRegnvRVSRELPGHTGYLSCCRFLDDGQII-TSSGDTTCALWDIETGQ 86
Cdd:COG2319  120 TGAVRSVAFSPDGKTLASGSADGTVRLWDLATG----KLLRTLTGHSGAVTSVAFSPDGKLLaSGSDDGTVRLWDLATGK 195

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920784  87 QTTTFTGHSGDVMSLSLSPDLKTFVSGACDASSKLWDIRDGMCRQSFTGHISDINAVSFFPSGYAFATGSDDATCRLFDL 166
Cdd:COG2319  196 LLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDL 275

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920784 167 RADQELLLYSHDNiiCGITSVAFSKSGRLLLAGYDDFNCSVWDALKGGRSGVLAGHDNRVSCLGVTDDGMAVATGSWDSF 246
Cdd:COG2319  276 ATGELLRTLTGHS--GGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGT 353


                 ....*
gi 568920784 247 LRIWN 251
Cdd:COG2319  354 VRLWD 358
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 8-242 4.77e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 47.39  E-value: 4.77e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920784   8 SSWVMTCAYAPSGNYVACGGLDNICSIYNLKT-----REGNVRVSrELPGHTGYLSCC-RFLDDGQIITSSGDTTCALWD 81
Cdd:PLN00181 483 SNLVCAIGFDRDGEFFATAGVNKKIKIFECESiikdgRDIHYPVV-ELASRSKLSGICwNSYIKSQVASSNFEGVVQVWD 561

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920784  82 IETGQQTTTFTGHSGDVMSLSLSP-DLKTFVSGACDASSKLWDIRDGMCRQSFTGHiSDINAVSfFPS--GYAFATGSDD 158
Cdd:PLN00181 562 VARSQLVTEMKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQGVSIGTIKTK-ANICCVQ-FPSesGRSLAFGSAD 639

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920784 159 ATCRLFDLRADQELL--LYSHDNIicgITSVAFSKSGRLLLAGYDDfNCSVWDaLKGGRSGV-------LAGHDNRVSCL 229
Cdd:PLN00181 640 HKVYYYDLRNPKLPLctMIGHSKT---VSYVRFVDSSTLVSSSTDN-TLKLWD-LSMSISGInetplhsFMGHTNVKNFV 714

                        250
                 ....*....|...
gi 568920784 230 GVTDDGMAVATGS 242
Cdd:PLN00181 715 GLSVSDGYIATGS 727
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 126-165 1.04e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.53  E-value: 1.04e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 568920784   126 DGMCRQSFTGHISDINAVSFFPSGYAFATGSDDATCRLFD 165
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
127-165 5.65e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.64  E-value: 5.65e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 568920784  127 GMCRQSFTGHISDINAVSFFPSGYAFATGSDDATCRLFD 165
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 8-251 2.38e-66

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 207.19  E-value: 2.38e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920784   8 SSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREgnvrVSRELPGHTGYLSCCRFLDDGQIITSSG-DTTCALWDIETGQ 86
Cdd:cd00200   51 TGPVRDVAASADGTYLASGSSDKTIRLWDLETGE----CVRTLTGHTSYVSSVAFSPDGRILSSSSrDKTIKVWDVETGK 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920784  87 QTTTFTGHSGDVMSLSLSPDlKTFVSGAC-DASSKLWDIRDGMCRQSFTGHISDINAVSFFPSGYAFATGSDDATCRLFD 165
Cdd:cd00200  127 CLTTLRGHTDWVNSVAFSPD-GTFVASSSqDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWD 205

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920784 166 LRADQEL-LLYSHDNIICgitSVAFSKSGRLLLAGYDDFNCSVWDALKGGRSGVLAGHDNRVSCLGVTDDGMAVATGSWD 244
Cdd:cd00200  206 LSTGKCLgTLRGHENGVN---SVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSAD 282


                 ....*..
gi 568920784 245 SFLRIWN 251
Cdd:cd00200  283 GTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
8-251 1.05e-50

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 170.48  E-value: 1.05e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920784   8 SSWVMTCAYAPSGNYVACGGLDNICSIYNLKTRegnvRVSRELPGHTGYLSCCRFLDDGQII-TSSGDTTCALWDIETGQ 86
Cdd:COG2319  120 TGAVRSVAFSPDGKTLASGSADGTVRLWDLATG----KLLRTLTGHSGAVTSVAFSPDGKLLaSGSDDGTVRLWDLATGK 195

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920784  87 QTTTFTGHSGDVMSLSLSPDLKTFVSGACDASSKLWDIRDGMCRQSFTGHISDINAVSFFPSGYAFATGSDDATCRLFDL 166
Cdd:COG2319  196 LLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDL 275

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920784 167 RADQELLLYSHDNiiCGITSVAFSKSGRLLLAGYDDFNCSVWDALKGGRSGVLAGHDNRVSCLGVTDDGMAVATGSWDSF 246
Cdd:COG2319  276 ATGELLRTLTGHS--GGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGT 353


                 ....*
gi 568920784 247 LRIWN 251
Cdd:COG2319  354 VRLWD 358
WD40 COG2319
WD40 repeat [General function prediction only];
8-251 3.73e-50

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 168.94  E-value: 3.73e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920784   8 SSWVMTCAYAPSGNYVACGGLDNICSIYNLKTRegnvRVSRELPGHTGYLSCCRFLDDGQII-TSSGDTTCALWDIETGQ 86
Cdd:COG2319  162 SGAVTSVAFSPDGKLLASGSDDGTVRLWDLATG----KLLRTLTGHTGAVRSVAFSPDGKLLaSGSADGTVRLWDLATGK 237

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920784  87 QTTTFTGHSGDVMSLSLSPDLKTFVSGACDASSKLWDIRDGMCRQSFTGHISDINAVSFFPSGYAFATGSDDATCRLFDL 166
Cdd:COG2319  238 LLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDL 317

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920784 167 RADQelLLYSHDNIICGITSVAFSKSGRLLLAGYDDFNCSVWDALKGGRSGVLAGHDNRVSCLGVTDDGMAVATGSWDSF 246
Cdd:COG2319  318 ATGK--LLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGT 395


                 ....*
gi 568920784 247 LRIWN 251
Cdd:COG2319  396 VRLWD 400
WD40 COG2319
WD40 repeat [General function prediction only];
8-251 3.16e-42

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 148.14  E-value: 3.16e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920784   8 SSWVMTCAYAPSGNYVACGGLDNIcsiyNLKTREGNVRVSRELPGHTGYLSCCRFLDDGQII-TSSGDTTCALWDIETGQ 86
Cdd:COG2319   36 AAAVASLAASPDGARLAAGAGDLT----LLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLaSASADGTVRLWDLATGL 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920784  87 QTTTFTGHSGDVMSLSLSPDLKTFVSGACDASSKLWDIRDGMCRQSFTGHISDINAVSFFPSGYAFATGSDDATCRLFDL 166
Cdd:COG2319  112 LLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDL 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920784 167 RADQELL-LYSHDNiicGITSVAFSKSGRLLLAGYDDFNCSVWDALKGGRSGVLAGHDNRVSCLGVTDDGMAVATGSWDS 245
Cdd:COG2319  192 ATGKLLRtLTGHTG---AVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADG 268


                 ....*.
gi 568920784 246 FLRIWN 251
Cdd:COG2319  269 TVRLWD 274
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 47-251 2.05e-39

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 137.85  E-value: 2.05e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920784  47 SRELPGHTGYLSCCRFLDDGQ-IITSSGDTTCALWDIETGQQTTTFTGHSGDVMSLSLSPDLKTFVSGACDASSKLWDIR 125
Cdd:cd00200    2 RRTLKGHTGGVTCVAFSPDGKlLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920784 126 DGMCRQSFTGHISDINAVSFFPSGYAFATGSDDATCRLFDLRADQEL-LLYSHDniiCGITSVAFSKSGRLLLAGYDDFN 204
Cdd:cd00200   82 TGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLtTLRGHT---DWVNSVAFSPDGTFVASSSQDGT 158

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 568920784 205 CSVWDALKGGRSGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLRIWN 251
Cdd:cd00200  159 IKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWD 205
WD40 COG2319
WD40 repeat [General function prediction only];
2-210 1.73e-38

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 138.51  E-value: 1.73e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920784   2 HAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREgnvrVSRELPGHTGYLSCCRFLDDGQII-TSSGDTTCALW 80
Cdd:COG2319  198 RTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGK----LLRTLTGHSGSVRSVAFSPDGRLLaSGSADGTVRLW 273

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920784  81 DIETGQQTTTFTGHSGDVMSLSLSPDLKTFVSGACDASSKLWDIRDGMCRQSFTGHISDINAVSFFPSGYAFATGSDDAT 160
Cdd:COG2319  274 DLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGT 353

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 568920784 161 CRLFDLRADQELL-LYSHDNiicGITSVAFSKSGRLLLAGYDDFNCSVWDA 210
Cdd:COG2319  354 VRLWDLATGELLRtLTGHTG---AVTSVAFSPDGRTLASGSADGTVRLWDL 401
WD40 COG2319
WD40 repeat [General function prediction only];
37-251 6.05e-36

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 131.57  E-value: 6.05e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920784  37 LKTREGNVRVSRELPGHTGYLSCCRFLDDGQIITSSGDTTCALWDIETGQQTTTFTGHSGDVMSLSLSPDLKTFVSGACD 116
Cdd:COG2319   20 LLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASAD 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920784 117 ASSKLWDIRDGMCRQSFTGHISDINAVSFFPSGYAFATGSDDATCRLFDLRADQELL-LYSHDNiicGITSVAFSKSGRL 195
Cdd:COG2319  100 GTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRtLTGHSG---AVTSVAFSPDGKL 176

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 568920784 196 LLAGYDDFNCSVWDALKGGRSGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLRIWN 251
Cdd:COG2319  177 LASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWD 232
WD40 COG2319
WD40 repeat [General function prediction only];
2-167 6.52e-29

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 112.70  E-value: 6.52e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920784   2 HAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREgnvrVSRELPGHTGYLSCCRFLDDGQ-IITSSGDTTCALW 80
Cdd:COG2319  240 RTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGE----LLRTLTGHSGGVNSVAFSPDGKlLASGSDDGTVRLW 315

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920784  81 DIETGQQTTTFTGHSGDVMSLSLSPDLKTFVSGACDASSKLWDIRDGMCRQSFTGHISDINAVSFFPSGYAFATGSDDAT 160
Cdd:COG2319  316 DLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGT 395


                 ....*..
gi 568920784 161 CRLFDLR 167
Cdd:COG2319  396 VRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
61-251 6.50e-25

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 101.53  E-value: 6.50e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920784  61 RFLDDGQIITSSGDTTCALWDIETGQQTTTFTGHSGDVMSLSLSPDLKTFVSGACDASSKLWDIRDGMCRQSFTGHISDI 140
Cdd:COG2319    2 LSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920784 141 NAVSFFPSGYAFATGSDDATCRLFDLRADQEL-LLYSHDNiicGITSVAFSKSGRLLLAGYDDFNCSVWDALKGGRSGVL 219
Cdd:COG2319   82 LSVAFSPDGRLLASASADGTVRLWDLATGLLLrTLTGHTG---AVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTL 158

                        170       180       190
                 ....*....|....*....|....*....|..
gi 568920784 220 AGHDNRVSCLGVTDDGMAVATGSWDSFLRIWN 251
Cdd:COG2319  159 TGHSGAVTSVAFSPDGKLLASGSDDGTVRLWD 190
WD40 COG2319
WD40 repeat [General function prediction only];
8-126 2.15e-17

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 80.73  E-value: 2.15e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920784   8 SSWVMTCAYAPSGNYVACGGLDNICSIYNLKTRegnvRVSRELPGHTGYLSCCRFLDDGQ-IITSSGDTTCALWDIETGQ 86
Cdd:COG2319  288 SGGVNSVAFSPDGKLLASGSDDGTVRLWDLATG----KLLRTLTGHTGAVRSVAFSPDGKtLASGSDDGTVRLWDLATGE 363

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 568920784  87 QTTTFTGHSGDVMSLSLSPDLKTFVSGACDASSKLWDIRD 126
Cdd:COG2319  364 LLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 129-251 2.86e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 78.92  E-value: 2.86e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920784 129 CRQSFTGHISDINAVSFFPSGYAFATGSDDATCRLFDLRADQELL-LYSHDNiicGITSVAFSKSGRLLLAGYDDFNCSV 207
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRtLKGHTG---PVRDVAASADGTYLASGSSDKTIRL 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 568920784 208 WDALKGGRSGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLRIWN 251
Cdd:cd00200   78 WDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWD 121
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 8-242 4.77e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 47.39  E-value: 4.77e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920784   8 SSWVMTCAYAPSGNYVACGGLDNICSIYNLKT-----REGNVRVSrELPGHTGYLSCC-RFLDDGQIITSSGDTTCALWD 81
Cdd:PLN00181 483 SNLVCAIGFDRDGEFFATAGVNKKIKIFECESiikdgRDIHYPVV-ELASRSKLSGICwNSYIKSQVASSNFEGVVQVWD 561

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920784  82 IETGQQTTTFTGHSGDVMSLSLSP-DLKTFVSGACDASSKLWDIRDGMCRQSFTGHiSDINAVSfFPS--GYAFATGSDD 158
Cdd:PLN00181 562 VARSQLVTEMKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQGVSIGTIKTK-ANICCVQ-FPSesGRSLAFGSAD 639

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568920784 159 ATCRLFDLRADQELL--LYSHDNIicgITSVAFSKSGRLLLAGYDDfNCSVWDaLKGGRSGV-------LAGHDNRVSCL 229
Cdd:PLN00181 640 HKVYYYDLRNPKLPLctMIGHSKT---VSYVRFVDSSTLVSSSTDN-TLKLWD-LSMSISGInetplhsFMGHTNVKNFV 714

                        250
                 ....*....|...
gi 568920784 230 GVTDDGMAVATGS 242
Cdd:PLN00181 715 GLSVSDGYIATGS 727
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 126-165 1.04e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.53  E-value: 1.04e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 568920784   126 DGMCRQSFTGHISDINAVSFFPSGYAFATGSDDATCRLFD 165
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
127-165 5.65e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.64  E-value: 5.65e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 568920784  127 GMCRQSFTGHISDINAVSFFPSGYAFATGSDDATCRLFD 165
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
217-251 3.44e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.32  E-value: 3.44e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 568920784  217 GVLAGHDNRVSCLGVTDDGMAVATGSWDSFLRIWN 251
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 218-251 6.19e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.52  E-value: 6.19e-04
                           10        20        30
                   ....*....|....*....|....*....|....
gi 568920784   218 VLAGHDNRVSCLGVTDDGMAVATGSWDSFLRIWN 251
Cdd:smart00320   7 TLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 222-250 3.45e-03

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 38.13  E-value: 3.45e-03
                          10        20
                  ....*....|....*....|....*....
gi 568920784  222 HDNRVSCLGVTDDGMAVATGSWDSFLRIW 250
Cdd:pfam20426 123 HKDVVSCVAVTSDGSILATGSYDTTVMVW 151
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 45-81 5.37e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 33.83  E-value: 5.37e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 568920784    45 RVSRELPGHTGYLSCCRFLDDGQ-IITSSGDTTCALWD 81
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKyLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
48-81 7.86e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 33.47  E-value: 7.86e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 568920784   48 RELPGHTGYLSCCRFLDDGQ-IITSSGDTTCALWD 81
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSPDGKlLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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