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Conserved domains on  [gi|568926915|ref|XP_006538092|]
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centlein isoform X5 [Mus musculus]

Protein Classification

coiled-coil domain-containing protein( domain architecture ID 1000095)

coiled-coil domain-containing protein contains a region with alpha-helical coiled-coil sequence signatures that is being annotated by a variety of protein family models, not necessarily indicating family membership

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SMC_prok_B super family cl37069
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 66-841 9.87e-15

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


The actual alignment was detected with superfamily member TIGR02168:

Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 78.95  E-value: 9.87e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926915    66 KLKKAERKIENLEKTLQLKSQENDELRDAHEKRKERLQMLHTNYRAVKEQLKQWEEDsgmaesRQMKRAEPHQLRQEdSD 145
Cdd:TIGR02168  247 ELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQ------KQILRERLANLERQ-LE 319

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926915   146 AVWNELAYFKRENQELMVQKMTLQDELDELKMHMSIDKTTIQELN--RCMAEKREEQLFRQHEDAEVKKSTPEKNEKAIS 223
Cdd:TIGR02168  320 ELEAQLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEaeLEELESRLEELEEQLETLRSKVAQLELQIASLN 399

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926915   224 EEtlqkVIELENRLKSFEKNSRKLKEESKRLKKEndFLKSHLKHYQEDSEAREKELEQLLRVSKDVEHDKSELQTKITAL 303
Cdd:TIGR02168  400 NE----IERLEARLERLEDRRERLQQEIEELLKK--LEEAELKELQAELEELEEELEELQEELERLEEALEELREELEEA 473

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926915   304 ETEVTTLRRQVTEAKALRGKDEEVvcpEERAHRPTDKAKSEMATTDVRARRCDCKTATTKV--KFKAAKRK-CSVGRHHT 380
Cdd:TIGR02168  474 EQALDAAERELAQLQARLDSLERL---QENLEGFSEGVKALLKNQSGLSGILGVLSELISVdeGYEAAIEAaLGGRLQAV 550

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926915   381 VLNHSIKVMSHVENLSKdgwedvsegsSDSETQTFQNLGTI----IVETSQNISPIEDGRNQKEIDQTEGSCAQQRAMQ- 455
Cdd:TIGR02168  551 VVENLNAAKKAIAFLKQ----------NELGRVTFLPLDSIkgteIQGNDREILKNIEGFLGVAKDLVKFDPKLRKALSy 620

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926915   456 ----TYSCEDIKAPQSIShNKNTKKMTFQKKSGSLQKSLHSALPARVNREkcknlpaqkssSSTISLRERIVSLQQQNSL 531
Cdd:TIGR02168  621 llggVLVVDDLDNALELA-KKLRPGYRIVTLDGDLVRPGGVITGGSAKTN-----------SSILERRREIEELEEKIEE 688

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926915   532 LQNARRAAEASAKEYKEANEKLLHQQQVSDHRFQTSRQTIKKLTLDLAELRKEKEDLLKKVESSSDIMSLAEEVSRIMAP 611
Cdd:TIGR02168  689 LEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEE 768

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926915   612 QIKVTTLGPSRSMDlEMKQLQCKLKNATNELTKQSSNVKSLRMELLAKDDHIKEMHERTSRMERDITMKRHLIEDLKFRQ 691
Cdd:TIGR02168  769 RLEEAEEELAEAEA-EIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQI 847

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926915   692 KVNSESNESFNEMLETLEKKVKSLTEEcsnkkvsvdslkqrLNVAVKEKSQYEQMYQKTKEELEKKDlkmsvliSKLNDT 771
Cdd:TIGR02168  848 EELSEDIESLAAEIEELEELIEELESE--------------LEALLNERASLEEALALLRSELEELS-------EELREL 906

                          730       740       750       760       770       780       790
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568926915   772 ETAMAQIETAASEqLQGLALQSEQVLEGAQKKLLSANEKI-EEFTV---FVKALVNELQSDVHGTRHQIRELKK 841
Cdd:TIGR02168  907 ESKRSELRRELEE-LREKLAQLELRLEGLEVRIDNLQERLsEEYSLtleEAEALENKIEDDEEEARRRLKRLEN 979
 
Name Accession Description Interval E-value
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 66-841 9.87e-15

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 78.95  E-value: 9.87e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926915    66 KLKKAERKIENLEKTLQLKSQENDELRDAHEKRKERLQMLHTNYRAVKEQLKQWEEDsgmaesRQMKRAEPHQLRQEdSD 145
Cdd:TIGR02168  247 ELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQ------KQILRERLANLERQ-LE 319

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926915   146 AVWNELAYFKRENQELMVQKMTLQDELDELKMHMSIDKTTIQELN--RCMAEKREEQLFRQHEDAEVKKSTPEKNEKAIS 223
Cdd:TIGR02168  320 ELEAQLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEaeLEELESRLEELEEQLETLRSKVAQLELQIASLN 399

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926915   224 EEtlqkVIELENRLKSFEKNSRKLKEESKRLKKEndFLKSHLKHYQEDSEAREKELEQLLRVSKDVEHDKSELQTKITAL 303
Cdd:TIGR02168  400 NE----IERLEARLERLEDRRERLQQEIEELLKK--LEEAELKELQAELEELEEELEELQEELERLEEALEELREELEEA 473

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926915   304 ETEVTTLRRQVTEAKALRGKDEEVvcpEERAHRPTDKAKSEMATTDVRARRCDCKTATTKV--KFKAAKRK-CSVGRHHT 380
Cdd:TIGR02168  474 EQALDAAERELAQLQARLDSLERL---QENLEGFSEGVKALLKNQSGLSGILGVLSELISVdeGYEAAIEAaLGGRLQAV 550

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926915   381 VLNHSIKVMSHVENLSKdgwedvsegsSDSETQTFQNLGTI----IVETSQNISPIEDGRNQKEIDQTEGSCAQQRAMQ- 455
Cdd:TIGR02168  551 VVENLNAAKKAIAFLKQ----------NELGRVTFLPLDSIkgteIQGNDREILKNIEGFLGVAKDLVKFDPKLRKALSy 620

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926915   456 ----TYSCEDIKAPQSIShNKNTKKMTFQKKSGSLQKSLHSALPARVNREkcknlpaqkssSSTISLRERIVSLQQQNSL 531
Cdd:TIGR02168  621 llggVLVVDDLDNALELA-KKLRPGYRIVTLDGDLVRPGGVITGGSAKTN-----------SSILERRREIEELEEKIEE 688

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926915   532 LQNARRAAEASAKEYKEANEKLLHQQQVSDHRFQTSRQTIKKLTLDLAELRKEKEDLLKKVESSSDIMSLAEEVSRIMAP 611
Cdd:TIGR02168  689 LEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEE 768

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926915   612 QIKVTTLGPSRSMDlEMKQLQCKLKNATNELTKQSSNVKSLRMELLAKDDHIKEMHERTSRMERDITMKRHLIEDLKFRQ 691
Cdd:TIGR02168  769 RLEEAEEELAEAEA-EIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQI 847

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926915   692 KVNSESNESFNEMLETLEKKVKSLTEEcsnkkvsvdslkqrLNVAVKEKSQYEQMYQKTKEELEKKDlkmsvliSKLNDT 771
Cdd:TIGR02168  848 EELSEDIESLAAEIEELEELIEELESE--------------LEALLNERASLEEALALLRSELEELS-------EELREL 906

                          730       740       750       760       770       780       790
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568926915   772 ETAMAQIETAASEqLQGLALQSEQVLEGAQKKLLSANEKI-EEFTV---FVKALVNELQSDVHGTRHQIRELKK 841
Cdd:TIGR02168  907 ESKRSELRRELEE-LREKLAQLELRLEGLEVRIDNLQERLsEEYSLtleEAEALENKIEDDEEEARRRLKRLEN 979
PRK00409 PRK00409
recombination and DNA strand exchange inhibitor protein; Reviewed
 691-813 2.29e-05

recombination and DNA strand exchange inhibitor protein; Reviewed


Pssm-ID: 234750 [Multi-domain]  Cd Length: 782  Bit Score: 48.28  E-value: 2.29e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926915 691 QKVNSESNESFNEM---LETLEKKVKSLTEECSNKKVSVDSLKQRLNvavKEKSQYEQMYQKTKEELEKKdLKMSVLISK 767
Cdd:PRK00409 508 KKLIGEDKEKLNELiasLEELERELEQKAEEAEALLKEAEKLKEELE---EKKEKLQEEEDKLLEEAEKE-AQQAIKEAK 583

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 568926915 768 lndtETAMAQIETAASEQLQGLALQSEQVLEGAQKKLLSANEKIEE 813
Cdd:PRK00409 584 ----KEADEIIKELRQLQKGGYASVKAHELIEARKRLNKANEKKEK 625
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 62-327 1.32e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 42.62  E-value: 1.32e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926915  62 EELR-KLKKAERKIENLEKTLQLKSQENDELRDAHEKRKERLQMLHTNYRAVKEQLKQWEEdsgmaesrqmkraephqlr 140
Cdd:COG1196  270 EELRlELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEE------------------- 330

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926915 141 qedsdavwnELAYFKRENQELMVQKMTLQDELDELKMHMSIDKTTIQELNRCMAEKREEQLFRQHEDAEVKKSTpeknek 220
Cdd:COG1196  331 ---------ELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAA------ 395

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926915 221 aisEETLQKVIELENRLKSFEKNSRKLKEESKRLKKENDFLKSHLKHYQEDSEAREKELEQLLRVSKDVEHDKSELQTKI 300
Cdd:COG1196  396 ---AELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEA 472

                        250       260
                 ....*....|....*....|....*..
gi 568926915 301 TALETEVTTLRRQVTEAKALRGKDEEV 327
Cdd:COG1196  473 ALLEAALAELLEELAEAAARLLLLLEA 499
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 62-319 1.89e-03

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 42.03  E-value: 1.89e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926915   62 EELRKLKKAERKIENLEKTLQLKSQEN-----DELRDAHEKRKERLQMLHTNYRAVKEQLKQWEEDSGMAESRQMKRAEP 136
Cdd:pfam17380 306 EEKAREVERRRKLEEAEKARQAEMDRQaaiyaEQERMAMERERELERIRQEERKRELERIRQEEIAMEISRMRELERLQM 385

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926915  137 HqlRQEDSDAVWNEL-AYFKRENQELMVQKMTLQDELDELKMHMSIDKTTIQELNRCMAEK-------REEQLFRQHEDA 208
Cdd:pfam17380 386 E--RQQKNERVRQELeAARKVKILEEERQRKIQQQKVEMEQIRAEQEEARQREVRRLEEERaremervRLEEQERQQQVE 463

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926915  209 EVKKSTPEKNEKAIS---EETLQKVIELENRL---KSFEKNSRKLKEESKRLKKENDFLKSHLKHYQEDSEAREKELEQl 282
Cdd:pfam17380 464 RLRQQEEERKRKKLElekEKRDRKRAEEQRRKileKELEERKQAMIEEERKRKLLEKEMEERQKAIYEEERRREAEEER- 542

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 568926915  283 lRVSKDVEHDK---------SELQTKITALETEVTTLRRQVTEAKA 319
Cdd:pfam17380 543 -RKQQEMEERRriqeqmrkaTEERSRLEAMEREREMMRQIVESEKA 587
 
Name Accession Description Interval E-value
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 66-841 9.87e-15

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 78.95  E-value: 9.87e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926915    66 KLKKAERKIENLEKTLQLKSQENDELRDAHEKRKERLQMLHTNYRAVKEQLKQWEEDsgmaesRQMKRAEPHQLRQEdSD 145
Cdd:TIGR02168  247 ELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQ------KQILRERLANLERQ-LE 319

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926915   146 AVWNELAYFKRENQELMVQKMTLQDELDELKMHMSIDKTTIQELN--RCMAEKREEQLFRQHEDAEVKKSTPEKNEKAIS 223
Cdd:TIGR02168  320 ELEAQLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEaeLEELESRLEELEEQLETLRSKVAQLELQIASLN 399

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926915   224 EEtlqkVIELENRLKSFEKNSRKLKEESKRLKKEndFLKSHLKHYQEDSEAREKELEQLLRVSKDVEHDKSELQTKITAL 303
Cdd:TIGR02168  400 NE----IERLEARLERLEDRRERLQQEIEELLKK--LEEAELKELQAELEELEEELEELQEELERLEEALEELREELEEA 473

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926915   304 ETEVTTLRRQVTEAKALRGKDEEVvcpEERAHRPTDKAKSEMATTDVRARRCDCKTATTKV--KFKAAKRK-CSVGRHHT 380
Cdd:TIGR02168  474 EQALDAAERELAQLQARLDSLERL---QENLEGFSEGVKALLKNQSGLSGILGVLSELISVdeGYEAAIEAaLGGRLQAV 550

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926915   381 VLNHSIKVMSHVENLSKdgwedvsegsSDSETQTFQNLGTI----IVETSQNISPIEDGRNQKEIDQTEGSCAQQRAMQ- 455
Cdd:TIGR02168  551 VVENLNAAKKAIAFLKQ----------NELGRVTFLPLDSIkgteIQGNDREILKNIEGFLGVAKDLVKFDPKLRKALSy 620

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926915   456 ----TYSCEDIKAPQSIShNKNTKKMTFQKKSGSLQKSLHSALPARVNREkcknlpaqkssSSTISLRERIVSLQQQNSL 531
Cdd:TIGR02168  621 llggVLVVDDLDNALELA-KKLRPGYRIVTLDGDLVRPGGVITGGSAKTN-----------SSILERRREIEELEEKIEE 688

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926915   532 LQNARRAAEASAKEYKEANEKLLHQQQVSDHRFQTSRQTIKKLTLDLAELRKEKEDLLKKVESSSDIMSLAEEVSRIMAP 611
Cdd:TIGR02168  689 LEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEE 768

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926915   612 QIKVTTLGPSRSMDlEMKQLQCKLKNATNELTKQSSNVKSLRMELLAKDDHIKEMHERTSRMERDITMKRHLIEDLKFRQ 691
Cdd:TIGR02168  769 RLEEAEEELAEAEA-EIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQI 847

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926915   692 KVNSESNESFNEMLETLEKKVKSLTEEcsnkkvsvdslkqrLNVAVKEKSQYEQMYQKTKEELEKKDlkmsvliSKLNDT 771
Cdd:TIGR02168  848 EELSEDIESLAAEIEELEELIEELESE--------------LEALLNERASLEEALALLRSELEELS-------EELREL 906

                          730       740       750       760       770       780       790
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568926915   772 ETAMAQIETAASEqLQGLALQSEQVLEGAQKKLLSANEKI-EEFTV---FVKALVNELQSDVHGTRHQIRELKK 841
Cdd:TIGR02168  907 ESKRSELRRELEE-LREKLAQLELRLEGLEVRIDNLQERLsEEYSLtleEAEALENKIEDDEEEARRRLKRLEN 979
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 65-326 3.57e-08

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 57.76  E-value: 3.57e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926915    65 RKLKKAERKIENLEKTLQLKSQENDELRDAHEKRKERLqmlhtnyravkEQLKQWEEDSGMAESRQMKRAEPHQLRQEDS 144
Cdd:TIGR02168  677 REIEELEEKIEELEEKIAELEKALAELRKELEELEEEL-----------EQLRKELEELSRQISALRKDLARLEAEVEQL 745

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926915   145 DAVWNELayfKRENQELMVQKMTLQDELDELKMHMSIDKTTIQELNRCMAEKREEqlFRQHEDAEVKKSTPEKNEKAISE 224
Cdd:TIGR02168  746 EERIAQL---SKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEE--LKALREALDELRAELTLLNEEAA 820

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926915   225 ETLQKVIELENRLKSFEKNSRKLKEESKRLKKENDFLKSHLKHYQEDSEAREKELEQLLRVSKDVEHDKSELQTKITALE 304
Cdd:TIGR02168  821 NLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNERASLEEALALLRSELEELS 900

                          250       260
                   ....*....|....*....|..
gi 568926915   305 TEVTTLRRQVTEAKALRGKDEE 326
Cdd:TIGR02168  901 EELRELESKRSELRRELEELRE 922
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 65-328 6.97e-08

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 56.61  E-value: 6.97e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926915    65 RKLKKAERKIENLEKTL----QLKSQENDELRDAHEKRKERLQmlhTNYRAVKEQLKQWEEDSGMAESRQMKRAEPHQLR 140
Cdd:TIGR02169  251 EELEKLTEEISELEKRLeeieQLLEELNKKIKDLGEEEQLRVK---EKIGELEAEIASLERSIAEKERELEDAEERLAKL 327

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926915   141 QEDSDAVWNELAYFKRENQELMVQKMTLQDELDELKMHMSIDKTTIQELNRCMAEKREEQLFRQHEDAEVKKstpEKNEK 220
Cdd:TIGR02169  328 EAEIDKLLAEIEELEREIEEERKRRDKLTEEYAELKEELEDLRAELEEVDKEFAETRDELKDYREKLEKLKR---EINEL 404

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926915   221 AISEETLQkvieleNRLKSFEKNSRKLKEESKRLKKENDFLKSHLKHYQEDSEAREKELEQLLRVSKDVEHDKSELQTKI 300
Cdd:TIGR02169  405 KRELDRLQ------EELQRLSEELADLNAAIAGIEAKINELEEEKEDKALEIKKQEWKLEQLAADLSKYEQELYDLKEEY 478

                          250       260
                   ....*....|....*....|....*...
gi 568926915   301 TALETEVTTLRRQVTEAKALRGKDEEVV 328
Cdd:TIGR02169  479 DRVEKELSKLQRELAEAEAQARASEERV 506
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 48-316 1.15e-06

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 52.76  E-value: 1.15e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926915    48 RSRSLSPKSSFMgSEELRKLKKA-ERKIENLEKTLQLKSQENDELRDAHEKRKE---RLQMLHTNYRAVKEQLKQWEED- 122
Cdd:TIGR02169  668 FSRSEPAELQRL-RERLEGLKRElSSLQSELRRIENRLDELSQELSDASRKIGEiekEIEQLEQEEEKLKERLEELEEDl 746

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926915   123 ----SGMAESRQMKRAEPHQLRQEDSDAVWNELAYFKRENQELMVQKMTLQDELDELK-MHMSIDKTTI---QELNRCMA 194
Cdd:TIGR02169  747 ssleQEIENVKSELKELEARIEELEEDLHKLEEALNDLEARLSHSRIPEIQAELSKLEeEVSRIEARLReieQKLNRLTL 826

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926915   195 EKREEQLFRQHEDAEVKKSTPEKNEKAISEETLQKVI-ELENRLKSFEKNSRKLKEESKRLKKENDFLKSHLKHYQEDSE 273
Cdd:TIGR02169  827 EKEYLEKEIQELQEQRIDLKEQIKSIEKEIENLNGKKeELEEELEELEAALRDLESRLGDLKKERDELEAQLRELERKIE 906

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|...
gi 568926915   274 AREKELEQLlrvskdvEHDKSELQTKITALETEVTTLRRQVTE 316
Cdd:TIGR02169  907 ELEAQIEKK-------RKRLSELKAKLEALEEELSEIEDPKGE 942
PRK00409 PRK00409
recombination and DNA strand exchange inhibitor protein; Reviewed
 691-813 2.29e-05

recombination and DNA strand exchange inhibitor protein; Reviewed


Pssm-ID: 234750 [Multi-domain]  Cd Length: 782  Bit Score: 48.28  E-value: 2.29e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926915 691 QKVNSESNESFNEM---LETLEKKVKSLTEECSNKKVSVDSLKQRLNvavKEKSQYEQMYQKTKEELEKKdLKMSVLISK 767
Cdd:PRK00409 508 KKLIGEDKEKLNELiasLEELERELEQKAEEAEALLKEAEKLKEELE---EKKEKLQEEEDKLLEEAEKE-AQQAIKEAK 583

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 568926915 768 lndtETAMAQIETAASEQLQGLALQSEQVLEGAQKKLLSANEKIEE 813
Cdd:PRK00409 584 ----KEADEIIKELRQLQKGGYASVKAHELIEARKRLNKANEKKEK 625
PTZ00121 PTZ00121
MAEBL; Provisional
 33-344 1.07e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 46.29  E-value: 1.07e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926915   33 SEKGTEGKHKEPPVKRSRSLSPKSS-FMGSEELRKLKKAERKIENLEKTLQLKSQENDELRDAHEKRKERLQMLHTNYRA 111
Cdd:PTZ00121 1443 AKKADEAKKKAEEAKKAEEAKKKAEeAKKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKAAEAKKKADEAKKAEEAK 1522

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926915  112 VKEQLKQWEEDSGMAESR---------------------QMKRAEPHQLRQEDSDAVWNELAYFKRENQELMVQKMTLQD 170
Cdd:PTZ00121 1523 KADEAKKAEEAKKADEAKkaeekkkadelkkaeelkkaeEKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYE 1602

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926915  171 ELDELKMHMSI----DKTTIQELNRCMAEKREEQLFRQHEDAEVKKSTPEKNEKaisEETLQKVIELENRLKSFEKNSRK 246
Cdd:PTZ00121 1603 EEKKMKAEEAKkaeeAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAE---EENKIKAAEEAKKAEEDKKKAEE 1679

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926915  247 LKEESKRLKKENDFLKSHLKHYQEDSEAREKELEQlLRVSKDVEHDKSELQTKITALETEVTTLRRQVTEAKALRGKDEE 326
Cdd:PTZ00121 1680 AKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEE-KKKAEELKKAEEENKIKAEEAKKEAEEDKKKAEEAKKDEEEKKK 1758

                         330
                  ....*....|....*...
gi 568926915  327 VVCPEERAHRPTDKAKSE 344
Cdd:PTZ00121 1759 IAHLKKEEEKKAEEIRKE 1776
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
62-323 6.86e-04

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 43.51  E-value: 6.86e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926915  62 EELRKLKKA----ERKIENLEKTLQLKSQENDELRDAHEKRKERLQMLHTNYRAVKEQLKQWEEDSGMAESRQMKRAEPH 137
Cdd:PRK03918 179 ERLEKFIKRteniEELIKEKEKELEEVLREINEISSELPELREELEKLEKEVKELEELKEEIEELEKELESLEGSKRKLE 258

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926915 138 QLRQEDSDAVwNELAYFKRENQELMVQKMTLQDELDELKMHMSIDKTTIQELNRcmAEKREEQLFRQHEDAEVKKSTPEK 217
Cdd:PRK03918 259 EKIRELEERI-EELKKEIEELEEKVKELKELKEKAEEYIKLSEFYEEYLDELRE--IEKRLSRLEEEINGIEERIKELEE 335

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926915 218 NEKAIsEETLQKVIELENRLKSFEKNSRKLkEESKRLKKENDFLKSHLKHYQedSEAREKELEQLLRVSKDVEHDKSELQ 297
Cdd:PRK03918 336 KEERL-EELKKKLKELEKRLEELEERHELY-EEAKAKKEELERLKKRLTGLT--PEKLEKELEELEKAKEEIEEEISKIT 411

                        250       260
                 ....*....|....*....|....*.
gi 568926915 298 TKITALETEVTTLRRQVTEAKALRGK 323
Cdd:PRK03918 412 ARIGELKKEIKELKKAIEELKKAKGK 437
PRK05771 PRK05771
V-type ATP synthase subunit I; Validated
 161-310 1.07e-03

V-type ATP synthase subunit I; Validated


Pssm-ID: 235600 [Multi-domain]  Cd Length: 646  Bit Score: 42.99  E-value: 1.07e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926915 161 LMVQKM------TLQDELDElkmhmsidktTIQELnrcmaekREEQLFrQHEDAEVKKSTpEKNEKAISEetLQKVIELE 234
Cdd:PRK05771   1 LAPVRMkkvlivTLKSYKDE----------VLEAL-------HELGVV-HIEDLKEELSN-ERLRKLRSL--LTKLSEAL 59

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568926915 235 NRLKSFEKNSRKLKEESKRLKKENdflkshlkhYQEDSEAREKELEQLLRVSKDVEHDKSELQTKITALETEVTTL 310
Cdd:PRK05771  60 DKLRSYLPKLNPLREEKKKVSVKS---------LEELIKDVEEELEKIEKEIKELEEEISELENEIKELEQEIERL 126
PTZ00121 PTZ00121
MAEBL; Provisional
 62-891 1.08e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 43.21  E-value: 1.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926915   62 EELRKLKKAeRKIENLEKTLQLKSQEndELRDAHEKRKERLQMLHTNYRAVkEQLKQWEEDSGMAESRQMKRAEPHQLRQ 141
Cdd:PTZ00121 1167 EEARKAEDA-KKAEAARKAEEVRKAE--ELRKAEDARKAEAARKAEEERKA-EEARKAEDAKKAEAVKKAEEAKKDAEEA 1242

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926915  142 EDSDAVWNELAYFKRENQELMVQKMTLQDELDElkmhmsiDKTTIQELNRCMAEKREEQLFRQHEDAEVKKSTPEKNEKA 221
Cdd:PTZ00121 1243 KKAEEERNNEEIRKFEEARMAHFARRQAAIKAE-------EARKADELKKAEEKKKADEAKKAEEKKKADEAKKKAEEAK 1315

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926915  222 ISEETLQKVIELENRLKSFEKNSRKLKEESKRLKKENDFLKSHLKHYQEDSEAREKELEQLLR----VSKDVEHDKSELQ 297
Cdd:PTZ00121 1316 KADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKkadaAKKKAEEKKKADE 1395

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926915  298 TKITALET-----EVTTLRRQVTEAKALRGKDEEVVCPEERAHRPTDKAKSEMATtdvrarrcdcKTATTKVKFKAAKRK 372
Cdd:PTZ00121 1396 AKKKAEEDkkkadELKKAAAAKKKADEAKKKAEEKKKADEAKKKAEEAKKADEAK----------KKAEEAKKAEEAKKK 1465

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926915  373 CSVGRHHTVLNHSIKVMSHVENLSKDGWEDVSEGSSDSETQtfqnlgtiivETSQNISPIEDGRNQKEIDQTEGSCAQQR 452
Cdd:PTZ00121 1466 AEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKAA----------EAKKKADEAKKAEEAKKADEAKKAEEAKK 1535

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926915  453 AMQTYSCEDIKAPQSISHNKNTKKMTFQKKSGSLQKSlhsalparvnrEKCKNLPAQKSSSSTISLRERIVSLQQQNSLL 532
Cdd:PTZ00121 1536 ADEAKKAEEKKKADELKKAEELKKAEEKKKAEEAKKA-----------EEDKNMALRKAEEAKKAEEARIEEVMKLYEEE 1604

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926915  533 QNARRAAEASAKEYKEANEKLLHQQQVsdhrfqtsRQTIKKLTLDLAELRKEKEDLLKkvesssdimslAEEVSRIMAPQ 612
Cdd:PTZ00121 1605 KKMKAEEAKKAEEAKIKAEELKKAEEE--------KKKVEQLKKKEAEEKKKAEELKK-----------AEEENKIKAAE 1665

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926915  613 ikvttlgpsrsmdleMKQLQCKLKNATNELTKQSSNVKSLRMELLAKDDHIKEMHERTSRMERDITMKrhliEDLKFRQK 692
Cdd:PTZ00121 1666 ---------------EAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKKKA----EELKKAEE 1726

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926915  693 VNSESNESFNEMLETLEKKVKSLTEECSNKKVSVDSLKQRLNVAVKEKSQYEQMyqkTKEELEKKDLKMSVLISKlndte 772
Cdd:PTZ00121 1727 ENKIKAEEAKKEAEEDKKKAEEAKKDEEEKKKIAHLKKEEEKKAEEIRKEKEAV---IEEELDEEDEKRRMEVDK----- 1798

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926915  773 tamaqietaaseQLQGLALQSEQVLEGAQKKLLSANEKIEEFTVFVKALVNELQSdvhgTRHQIRELKKMQKSRHACKTS 852
Cdd:PTZ00121 1799 ------------KIKDIFDNFANIIEGGKEGNLVINDSKEMEDSAIKEVADSKNM----QLEEADAFEKHKFNKNNENGE 1862

                         810       820       830
                  ....*....|....*....|....*....|....*....
gi 568926915  853 THKAQTLAASILNISRSDLEEILDTEDELEIEKTKIDIE 891
Cdd:PTZ00121 1863 DGNKEADFNKEKDLKEDDEEEIEEADEIEKIDKDDIERE 1901
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 62-327 1.32e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 42.62  E-value: 1.32e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926915  62 EELR-KLKKAERKIENLEKTLQLKSQENDELRDAHEKRKERLQMLHTNYRAVKEQLKQWEEdsgmaesrqmkraephqlr 140
Cdd:COG1196  270 EELRlELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEE------------------- 330

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926915 141 qedsdavwnELAYFKRENQELMVQKMTLQDELDELKMHMSIDKTTIQELNRCMAEKREEQLFRQHEDAEVKKSTpeknek 220
Cdd:COG1196  331 ---------ELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAA------ 395

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926915 221 aisEETLQKVIELENRLKSFEKNSRKLKEESKRLKKENDFLKSHLKHYQEDSEAREKELEQLLRVSKDVEHDKSELQTKI 300
Cdd:COG1196  396 ---AELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEA 472

                        250       260
                 ....*....|....*....|....*..
gi 568926915 301 TALETEVTTLRRQVTEAKALRGKDEEV 327
Cdd:COG1196  473 ALLEAALAELLEELAEAAARLLLLLEA 499
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 62-319 1.89e-03

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 42.03  E-value: 1.89e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926915   62 EELRKLKKAERKIENLEKTLQLKSQEN-----DELRDAHEKRKERLQMLHTNYRAVKEQLKQWEEDSGMAESRQMKRAEP 136
Cdd:pfam17380 306 EEKAREVERRRKLEEAEKARQAEMDRQaaiyaEQERMAMERERELERIRQEERKRELERIRQEEIAMEISRMRELERLQM 385

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926915  137 HqlRQEDSDAVWNEL-AYFKRENQELMVQKMTLQDELDELKMHMSIDKTTIQELNRCMAEK-------REEQLFRQHEDA 208
Cdd:pfam17380 386 E--RQQKNERVRQELeAARKVKILEEERQRKIQQQKVEMEQIRAEQEEARQREVRRLEEERaremervRLEEQERQQQVE 463

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926915  209 EVKKSTPEKNEKAIS---EETLQKVIELENRL---KSFEKNSRKLKEESKRLKKENDFLKSHLKHYQEDSEAREKELEQl 282
Cdd:pfam17380 464 RLRQQEEERKRKKLElekEKRDRKRAEEQRRKileKELEERKQAMIEEERKRKLLEKEMEERQKAIYEEERRREAEEER- 542

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 568926915  283 lRVSKDVEHDK---------SELQTKITALETEVTTLRRQVTEAKA 319
Cdd:pfam17380 543 -RKQQEMEERRriqeqmrkaTEERSRLEAMEREREMMRQIVESEKA 587
PTZ00121 PTZ00121
MAEBL; Provisional
 3-356 2.29e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 42.05  E-value: 2.29e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926915    3 SQKSEIEYLQKKLKVANEKLMANRSCDQDFSEkgTEGKHKEPPVKRSRSLSPKSSFMGSEELRKL----KKAE--RKIEN 76
Cdd:PTZ00121 1242 AKKAEEERNNEEIRKFEEARMAHFARRQAAIK--AEEARKADELKKAEEKKKADEAKKAEEKKKAdeakKKAEeaKKADE 1319

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926915   77 LEKTLQLKSQENDELRDAHEKRKERLQMLHTNYRAVKEQLKQWEEDSGMAE---SRQMKRAEPHQLRQEDsdavwnelay 153
Cdd:PTZ00121 1320 AKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEkkkEEAKKKADAAKKKAEE---------- 1389

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926915  154 fKRENQELMVQKMTLQDELDELKMHMSIDKTTIQELNRCMAEKREEQLFRQHEDAEVKKSTPEKNEKAISEETLQKVIEL 233
Cdd:PTZ00121 1390 -KKKADEAKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKAEEAKKKAEE 1468

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926915  234 ENRLKSFEKNSRKlKEESKRLKKENDFLKSHLKHYQEDSEAREK--ELEQLLRVSKDVEHDKSELQTKitALETEVTTLR 311
Cdd:PTZ00121 1469 AKKADEAKKKAEE-AKKADEAKKKAEEAKKKADEAKKAAEAKKKadEAKKAEEAKKADEAKKAEEAKK--ADEAKKAEEK 1545

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*
gi 568926915  312 RQVTEAKalrgKDEEVVCPEERahRPTDKAKSEMATTDVRARRCD 356
Cdd:PTZ00121 1546 KKADELK----KAEELKKAEEK--KKAEEAKKAEEDKNMALRKAE 1584
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
53-285 2.31e-03

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 41.68  E-value: 2.31e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926915  53 SPKSSFMGSEELRKLKKAERKIENLEKTLQLKSQENDELRDAHEKRKERLQMLHTNYRAVKEQLKQWEEDSGMAESRQmK 132
Cdd:COG4717   34 AGKSTLLAFIRAMLLERLEKEADELFKPQGRKPELNLKELKELEEELKEAEEKEEEYAELQEELEELEEELEELEAEL-E 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926915 133 RAEPHQLRQEDSDAVWNELAYFKRENQELMvqkmTLQDELDELKMHMsidkTTIQELNRCMAEKREEQLFRQHEDAEVKK 212
Cdd:COG4717  113 ELREELEKLEKLLQLLPLYQELEALEAELA----ELPERLEELEERL----EELRELEEELEELEAELAELQEELEELLE 184

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568926915 213 STPEKNEKAIsEETLQKVIELENRLKSFEKNSRKLKEESKRLKKENDFLKSHLKHYQEdsEAREKELEQLLRV 285
Cdd:COG4717  185 QLSLATEEEL-QDLAEELEELQQRLAELEEELEEAQEELEELEEELEQLENELEAAAL--EERLKEARLLLLI 254
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 101-814 2.61e-03

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 41.75  E-value: 2.61e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926915   101 RLQMLHTNYRA--VKEQLKQWEEDSGMAESRQ---MKRAEPHQLRQE---DSDAVWNELAYFKRENQELMVQKMTLQDE- 171
Cdd:pfam12128  259 RLSHLHFGYKSdeTLIASRQEERQETSAELNQllrTLDDQWKEKRDElngELSAADAAVAKDRSELEALEDQHGAFLDAd 338

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926915   172 LDELKMHMSIDKTTIQELNrcMAEKREEQLFRQHEDAEVKKstpEKNEKAISEETLQKVIELENRL-KSFEKNSRKLKEE 250
Cdd:pfam12128  339 IETAAADQEQLPSWQSELE--NLEERLKALTGKHQDVTAKY---NRRRSKIKEQNNRDIAGIKDKLaKIREARDRQLAVA 413

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926915   251 SKRLKKENDFLKShlKHYQEDSEAREKELEQLLRVSkdvehDKSELQTKITALETEVTTLRRQVTEAKALRGKDEEVVCP 330
Cdd:pfam12128  414 EDDLQALESELRE--QLEAGKLEFNEEEYRLKSRLG-----ELKLRLNQATATPELLLQLENFDERIERAREEQEAANAE 486

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926915   331 EERAHRPTDKAKSEMATTDVRARRCDcktattkvkFKAAKRKCSVGRHHTVLNHSIKVMSHVENLSKDGWEdvsegssds 410
Cdd:pfam12128  487 VERLQSELRQARKRRDQASEALRQAS---------RRLEERQSALDELELQLFPQAGTLLHFLRKEAPDWE--------- 548

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926915   411 etqtfQNLGTIIvetsqniSPIEDGRNQKEIDQTEGSCAQQRAMQ--TYSCEDIKAPQSISHNKNTKKMTFQKKSG---- 484
Cdd:pfam12128  549 -----QSIGKVI-------SPELLHRTDLDPEVWDGSVGGELNLYgvKLDLKRIDVPEWAASEEELRERLDKAEEAlqsa 616

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926915   485 -SLQKSLHSALP-ARVNREKCK---NLPAQKSSSSTISLRERIVSLQQQNSLLQNARRAAEASAKEYKEaneKLLHQQQV 559
Cdd:pfam12128  617 rEKQAAAEEQLVqANGELEKASreeTFARTALKNARLDLRRLFDEKQSEKDKKNKALAERKDSANERLN---SLEAQLKQ 693

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926915   560 SDHRFQTSRQTIKKltlDLAELRKEKEDLLKKVESSSDImSLAEEVSRIMAPQIkvttlgpsrSMDLEMKQLQCKLKNAT 639
Cdd:pfam12128  694 LDKKHQAWLEEQKE---QKREARTEKQAYWQVVEGALDA-QLALLKAAIAARRS---------GAKAELKALETWYKRDL 760

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926915   640 NELTKQSSNVKSLRMEllakddhIKEMHERTSRMERditmkrhliedlkFRQKVNsesnESFNEMLETLEKKVKSLTEEC 719
Cdd:pfam12128  761 ASLGVDPDVIAKLKRE-------IRTLERKIERIAV-------------RRQEVL----RYFDWYQETWLQRRPRLATQL 816

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926915   720 SNKKVSVDSLKQRLNVAVKEKSQYEQMYQKTKEELEKKDLKMSVLISKLNDTETAMAQI-ETAASEQLQGLALQSEQVLE 798
Cdd:pfam12128  817 SNIERAISELQQQLARLIADTKLRRAKLEMERKASEKQQVRLSENLRGLRCEMSKLATLkEDANSEQAQGSIGERLAQLE 896

                          730
                   ....*....|....*.
gi 568926915   799 GAQKKLLSANEKIEEF 814
Cdd:pfam12128  897 DLKLKRDYLSESVKKY 912
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
89-337 3.62e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 41.44  E-value: 3.62e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926915   89 DELRDAHEKRK--ERLQMLHTNYRAVKEQLkqweedsgmAESRQMKRAEPHQLRQEDSDAVWNELAYFKRENQELMVQKM 166
Cdd:COG4913   242 EALEDAREQIEllEPIRELAERYAAARERL---------AELEYLRAALRLWFAQRRLELLEAELEELRAELARLEAELE 312

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926915  167 TLQDELDElkmhmsidkttiqelnrcmAEKREEQLFRQHEDAEVKKSTPEKNEKAISEETLQkviELENRLKSFEKNSRK 246
Cdd:COG4913   313 RLEARLDA-------------------LREELDELEAQIRGNGGDRLEQLEREIERLERELE---ERERRRARLEALLAA 370

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926915  247 LKEESKRLKKENDFLKSHLKHYQEDSEAREKELEQ----LLRVSKDVEHDKSELQTKITALET-------EVTTLRRQVt 315
Cdd:COG4913   371 LGLPLPASAEEFAALRAEAAALLEALEEELEALEEalaeAEAALRDLRRELRELEAEIASLERrksnipaRLLALRDAL- 449

                         250       260       270
                  ....*....|....*....|....*....|
gi 568926915  316 eAKALRGKDEEV--------VCPEERAHRP 337
Cdd:COG4913   450 -AEALGLDEAELpfvgelieVRPEEERWRG 478
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
 127-321 3.95e-03

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 40.65  E-value: 3.95e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926915  127 ESRQMKRAEPHQLRQEDSDAVWNELAYFKRENQELMVQKMTLQDELDELKMHMSIDKTTIQELNR----------CMAEK 196
Cdd:pfam07888  37 EECLQERAELLQAQEAANRQREKEKERYKRDREQWERQRRELESRVAELKEELRQSREKHEELEEkykelsasseELSEE 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926915  197 ReEQLFRQHEDAEVKKSTPEKNEKAISEETLQKVIELENRLKSFEKNSRKLKEEskrlKKENDFLKSHLKHYQEDSEARE 276
Cdd:pfam07888 117 K-DALLAQRAAHEARIRELEEDIKTLTQRVLERETELERMKERAKKAGAQRKEE----EAERKQLQAKLQQTEEELRSLS 191

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 568926915  277 KELEQLLRVSKDVEHDKSELQTKITALETEVTTLRRQVTEAKALR 321
Cdd:pfam07888 192 KEFQELRNSLAQRDTQVLQLQDTITTLTQKLTTAHRKEAENEALL 236
Cast pfam10174
RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part ...
 65-304 4.07e-03

RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.


Pssm-ID: 431111 [Multi-domain]  Cd Length: 766  Bit Score: 40.96  E-value: 4.07e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926915   65 RKLKKAERKIENLEKTLQLKSQENDELrdahekrKERLQMLHTNYRAVKEQLKQWEEdsGMAESRQMKRAEPHQLRQEDS 144
Cdd:pfam10174 394 RKINVLQKKIENLQEQLRDKDKQLAGL-------KERVKSLQTDSSNTDTALTTLEE--ALSEKERIIERLKEQREREDR 464

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926915  145 DAVwNELAYFKRENQELMVQKMTLQDELDELKMHMSIDKTTIQELNRCMaekreeqlfrqhedaeVKKSTPEKNEKAISE 224
Cdd:pfam10174 465 ERL-EELESLKKENKDLKEKVSALQPELTEKESSLIDLKEHASSLASSG----------------LKKDSKLKSLEIAVE 527

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926915  225 ETLQKVIELENRLK---SFEKNSRKLKEESKRLKKendfLKSHLKHYQEDSEAREKELEQLLRVSKDVEHDKSELQTKIT 301
Cdd:pfam10174 528 QKKEECSKLENQLKkahNAEEAVRTNPEINDRIRL----LEQEVARYKEESGKAQAEVERLLGILREVENEKNDKDKKIA 603


                  ...
gi 568926915  302 ALE 304
Cdd:pfam10174 604 ELE 606
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 65-257 4.21e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 40.52  E-value: 4.21e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926915  65 RKLKKAERKIENLEKTLQLKSQENDELRDAHEKRKERL-QMLHTNYRavkeqlkqweedsgmaesrqMKRAEPHQ--LRQ 141
Cdd:COG4942   69 RRIRALEQELAALEAELAELEKEIAELRAELEAQKEELaELLRALYR--------------------LGRQPPLAllLSP 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926915 142 EDSDAVWNELAYFKRENQELMVQKMTLQDELDELkmhmsidKTTIQELNRCMAEKREEQLFRQHEDAEVKKstpEKNEKA 221
Cdd:COG4942  129 EDFLDAVRRLQYLKYLAPARREQAEELRADLAEL-------AALRAELEAERAELEALLAELEEERAALEA---LKAERQ 198

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 568926915 222 ISEETLQKVI-ELENRLKSFEKNSRKLKEESKRLKKE 257
Cdd:COG4942  199 KLLARLEKELaELAAELAELQQEAEELEALIARLEAE 235
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
580-931 4.49e-03

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 40.82  E-value: 4.49e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926915 580 ELRKEKEDLLKKVESSSDIMSLAEEVSRIMAPQIKVTTLGPSRSMDLEMKqlQCKLKNATNELTKQSSNVKSLRMELLAK 659
Cdd:PRK03918 173 EIKRRIERLEKFIKRTENIEELIKEKEKELEEVLREINEISSELPELREE--LEKLEKEVKELEELKEEIEELEKELESL 250

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926915 660 DDHIKEMHERTSRMERDITMKRHLIEDLKFRQKvNSESNESFNEMLETLEKKVKSLTEECSNKKVSVDSLKQRLNV---A 736
Cdd:PRK03918 251 EGSKRKLEEKIRELEERIEELKKEIEELEEKVK-ELKELKEKAEEYIKLSEFYEEYLDELREIEKRLSRLEEEINGieeR 329

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926915 737 VKEKSQYEQMYQKTKEELEKKDLKMSVLISKLNDTETAMaQIETAASEQLQGLALQSEQVLEGAQKKLLSANEKIEEFTV 816
Cdd:PRK03918 330 IKELEEKEERLEELKKKLKELEKRLEELEERHELYEEAK-AKKEELERLKKRLTGLTPEKLEKELEELEKAKEEIEEEIS 408

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926915 817 FVKALVNELQSDVHGTRHQIRELKKMQKSRHACK---TSTHKAQTLAASILNISR--SDLEEILDTEDELEIEKTKIDIE 891
Cdd:PRK03918 409 KITARIGELKKEIKELKKAIEELKKAKGKCPVCGrelTEEHRKELLEEYTAELKRieKELKEIEEKERKLRKELRELEKV 488

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|.
gi 568926915 892 NDKEWMLYIQKLLEGQLPFASYLLEAV-LEKIKENKKLTEG 931
Cdd:PRK03918 489 LKKESELIKLKELAEQLKELEEKLKKYnLEELEKKAEEYEK 529
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 71-847 5.01e-03

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 40.73  E-value: 5.01e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926915    71 ERKIENLEKTLQLKSQENDELRDAHEKRKERLQMLHTN---YRAVKEQLKQWEEDSGMAESRQMKRAEphQLRQEDSDAV 147
Cdd:pfam02463  169 RKKKEALKKLIEETENLAELIIDLEELKLQELKLKEQAkkaLEYYQLKEKLELEEEYLLYLDYLKLNE--ERIDLLQELL 246

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926915   148 WNELAYFKRENQELMVQKMTLQDELDELKMHMSIDKTTIQELNRCMAEKREEQLFRQHEDAEVKKstpEKNEKAISEETL 227
Cdd:pfam02463  247 RDEQEEIESSKQEIEKEEEKLAQVLKENKEEEKEKKLQEEELKLLAKEEEELKSELLKLERRKVD---DEEKLKESEKEK 323

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926915   228 QKVIELENRLKSFEKNSRKLKEESKRLKKENDFLKSHLKHYQEDSEAREKELEQLLRVSKDVEHDKSELQTKITALETEV 307
Cdd:pfam02463  324 KKAEKELKKEKEEIEELEKELKELEIKREAEEEEEEELEKLQEKLEQLEEELLAKKKLESERLSSAAKLKEEELELKSEE 403

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926915   308 TTLRRQVTEAKALRGKDEEVVCPEERAHRPTDKAKSEMATTDVRARRCDCKTATTKVKFKAAKRKCSVGRHHTVLNHSIK 387
Cdd:pfam02463  404 EKEAQLLLELARQLEDLLKEEKKEELEILEEEEESIELKQGKLTEEKEELEKQELKLLKDELELKKSEDLLKETQLVKLQ 483

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926915   388 VMSHVENLSKDGWEDVSEGSSDSETQTFQNLGTIIVETSQNISPIEDGRNQKEIDQTEgSCAQQRAMQTYSCEDIKAPQS 467
Cdd:pfam02463  484 EQLELLLSRQKLEERSQKESKARSGLKVLLALIKDGVGGRIISAHGRLGDLGVAVENY-KVAISTAVIVEVSATADEVEE 562

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926915   468 ISHNKNTKKMTFQKKSGSLQKSLHSALPARVNREKCKNLPAQKSSSSTISLRERiVSLQQQNSLLQNARRAAEASAKEYK 547
Cdd:pfam02463  563 RQKLVRALTELPLGARKLRLLIPKLKLPLKSIAVLEIDPILNLAQLDKATLEAD-EDDKRAKVVEGILKDTELTKLKESA 641

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926915   548 EANEKLLhQQQVSDHRFQTSRQTIKKLTLDLAELRKEKEDLLKKVESSSDIMSLAEEVSRIMAPQIKVTTlgpsrsmdlE 627
Cdd:pfam02463  642 KAKESGL-RKGVSLEEGLAEKSEVKASLSELTKELLEIQELQEKAESELAKEEILRRQLEIKKKEQREKE---------E 711

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926915   628 MKQLQCKLKNATNELTKQSSNVKSLRMELLAKDDHIKEMHERTSRMERDITMKRHLIEDLKFRQKVNSESNESFNEMLET 707
Cdd:pfam02463  712 LKKLKLEAEELLADRVQEAQDKINEELKLLKQKIDEEEEEEEKSRLKKEEKEEEKSELSLKEKELAEEREKTEKLKVEEE 791

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926915   708 LEKKVKSLTEECSNKKVSVDSLKQRLNVAVKEKSQYEQMYQKTKEELEkKDLKMSVLISKLNDTETAMAQIETAASEQLQ 787
Cdd:pfam02463  792 KEEKLKAQEEELRALEEELKEEAELLEEEQLLIEQEEKIKEEELEELA-LELKEEQKLEKLAEEELERLEEEITKEELLQ 870

                          730       740       750       760       770       780
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926915   788 GLALQSEQVLEGAQKKLLSanEKIEEFTVFVKALVNELQSDVHGTRHQIRELKKMQKSRH 847
Cdd:pfam02463  871 ELLLKEEELEEQKLKDELE--SKEEKEKEEKKELEEESQKLNLLEEKENEIEERIKEEAE 928
COG4026 COG4026
Uncharacterized conserved protein, contains TOPRIM domain, potential nuclease [General ...
 227-306 5.32e-03

Uncharacterized conserved protein, contains TOPRIM domain, potential nuclease [General function prediction only];


Pssm-ID: 443204 [Multi-domain]  Cd Length: 287  Bit Score: 39.71  E-value: 5.32e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926915 227 LQKVIELENRLKSFEKNSRKLKEESKRLKKENDFLKSHLKHYQEDSEAREKELEQLLRVSKDVEHDKSELQTKITALETE 306
Cdd:COG4026  127 IPEYNELREELLELKEKIDEIAKEKEKLTKENEELESELEELREEYKKLREENSILEEEFDNIKSEYSDLKSRFEELLKK 206
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 99-319 6.07e-03

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 40.44  E-value: 6.07e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926915    99 KERLQMLhtnyRAVKEQLKQwEEDSGMAESRQMKRaEPHQLRQEDSDAvwnelayfKRENQELMVQKMTLQDELDELKMH 178
Cdd:TIGR02169  673 PAELQRL----RERLEGLKR-ELSSLQSELRRIEN-RLDELSQELSDA--------SRKIGEIEKEIEQLEQEEEKLKER 738

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926915   179 MSIDKTTIQELNRCMAEKREEQlfrqhedAEVKKSTPEKNEKAISEETLQKVIE---LENRLKSFEKNSRKLKEESKRLK 255
Cdd:TIGR02169  739 LEELEEDLSSLEQEIENVKSEL-------KELEARIEELEEDLHKLEEALNDLEarlSHSRIPEIQAELSKLEEEVSRIE 811

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568926915   256 KENDFLKSHLKHYQEDSEAREKELEQLLRVSKDVEHDKSELQTKITALETEVTTLRRQVTEAKA 319
Cdd:TIGR02169  812 ARLREIEQKLNRLTLEKEYLEKEIQELQEQRIDLKEQIKSIEKEIENLNGKKEELEEELEELEA 875
COG2433 COG2433
Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];
212-318 8.40e-03

Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];


Pssm-ID: 441980 [Multi-domain]  Cd Length: 644  Bit Score: 39.84  E-value: 8.40e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926915 212 KSTPEKNEKAISEETlqkviELENRLKSFEKNSRKLKEESKRLKKENDFLKSHLkhyqEDSEAREKELEQLLRVSKDVEH 291
Cdd:COG2433  388 KELPEEEPEAEREKE-----HEERELTEEEEEIRRLEEQVERLEAEVEELEAEL----EEKDERIERLERELSEARSEER 458

                         90       100
                 ....*....|....*....|....*..
gi 568926915 292 DKSELQTKITALETEVTTLRRQVTEAK 318
Cdd:COG2433  459 REIRKDREISRLDREIERLERELEEER 485
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 577-808 8.79e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 39.36  E-value: 8.79e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926915 577 DLAELRKEKEDLLKKVESSSDIMSLAEEVSRIMAPQIKvttlgpsrSMDLEMKQLQCKLKNATNELTKQSSNVKSLRMEL 656
Cdd:COG4942   21 AAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLA--------ALERRIAALARRIRALEQELAALEAELAELEKEI 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926915 657 LAKDDHIKEMHERTSRMERDI-TMKRHLIEDLKFRQKVNSESNESFnEMLETLEKKVKSLTEECSNKKVSVDSLKQRLNV 735
Cdd:COG4942   93 AELRAELEAQKEELAELLRALyRLGRQPPLALLLSPEDFLDAVRRL-QYLKYLAPARREQAEELRADLAELAALRAELEA 171

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568926915 736 AVKEKSQYEQMYQKTKEELEKKDLKMSVLISKLNDTET---AMAQIETAASEQLQGLALQSEQVLEGAQKKLLSAN 808
Cdd:COG4942  172 ERAELEALLAELEEERAALEALKAERQKLLARLEKELAelaAELAELQQEAEELEALIARLEAEAAAAAERTPAAG 247
PLN02939 PLN02939
transferase, transferring glycosyl groups
 534-763 9.17e-03

transferase, transferring glycosyl groups


Pssm-ID: 215507 [Multi-domain]  Cd Length: 977  Bit Score: 39.89  E-value: 9.17e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926915 534 NARRAAEASAKEYKEANEKLLHQ-QQVSDHRFQTSRQTIKKLTLDLAELRKEKEdLLKkvessSDIMSLAEEVSRIMAPQ 612
Cdd:PLN02939 183 DARIKLAAQEKIHVEILEEQLEKlRNELLIRGATEGLCVHSLSKELDVLKEENM-LLK-----DDIQFLKAELIEVAETE 256

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926915 613 IKVTTLGPSRS-MDLEMKQLQCKLKNATNELTKQSSnvksLRME-LLAKDDHIKEMHER-TSRMERDITMkrhLIEDLKF 689
Cdd:PLN02939 257 ERVFKLEKERSlLDASLRELESKFIVAQEDVSKLSP----LQYDcWWEKVENLQDLLDRaTNQVEKAALV---LDQNQDL 329

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926915 690 RQKVN--SESNESFN------EMLETLEKKVKSLTEecsnkkvsvdslkqRLNVAVKEKSQYEQMYQ-----------KT 750
Cdd:PLN02939 330 RDKVDklEASLKEANvskfssYKVELLQQKLKLLEE--------------RLQASDHEIHSYIQLYQesikefqdtlsKL 395

                        250
                 ....*....|...
gi 568926915 751 KEELEKKDLKMSV 763
Cdd:PLN02939 396 KEESKKRSLEHPA 408
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 627-895 9.63e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 39.92  E-value: 9.63e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926915 627 EMKQLQCKLKNATNELTKQSSNVKSLRMELLAKDDHIKEMHE-------RTSRMERDItmkRHLIEDLKFRQkvnsesne 699
Cdd:COG1196  247 ELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAeeyellaELARLEQDI---ARLEERRRELE-------- 315

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926915 700 sfnEMLETLEKKVKSLTEECSNKKVSVDSLKQRLNVAVKEKSQYEQMYQKTKEELEKKDLKMSVLISKLNDTETAMAQIE 779
Cdd:COG1196  316 ---ERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEAL 392

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926915 780 TAASEQLQGL--ALQSEQVLEGAQKKLLSANEKIEEftvfvkALVNELQSDVHGTRHQIRELKKMQKSRHACKTSTHKAQ 857
Cdd:COG1196  393 RAAAELAAQLeeLEEAEEALLERLERLEEELEELEE------ALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLA 466

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 568926915 858 TLAASILNISRSDLEEILDTEDELEIEKTKIDIENDKE 895
Cdd:COG1196  467 ELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYE 504
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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