NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|568931246|ref|XP_006538930|]
View 

nephrocystin-4 isoform X1 [Mus musculus]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
NPHP4 cd22239
Nephrocystin-4; Nephrocystin-4 (NPHP4), also known as nephroretinin, is a component of the ...
55-1429 0e+00

Nephrocystin-4; Nephrocystin-4 (NPHP4), also known as nephroretinin, is a component of the nephronophthisis (NPHP) module which is part of the transition zone (TZ) of the cilia. NPHP4 forms complexes with alpha-tubulin, NPHP1 and RPGRIP1. The interaction with NPHP1 is crucial for cell-cell and cell-matrix adhesion signaling. Mutations in NPHP4 have been shown to cause nephronophthisis (NPHP), an autosomal recessive cause of kidney failure and earlier stages of chronic kidney disease among adults.


:

Pssm-ID: 412072  Cd Length: 904  Bit Score: 1222.57  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931246   55 ECHLRVTLFDVTYKHFFGRTWKTTVKPTNQPSKQPPRITFNEPLYFHTTLSHPSIVAVVEVVTEGRKRDGTLQLLSCGFG 134
Cdd:cd22239     1 EYQLRVSLFDSTYKHFFGRTWKSPSVTLKSSQGQKIKLLFNEPVYFHTSLNDPSIVAVVEVVAVEKDKDGIKNRTSCGWG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931246  135 ILRIFGNKPESP-TSAAQDKRLRLYHGTPRALLHPLLQDPIEQNKFMrlMENCSLQYTLKPHPPLEPAFHLLPENLLVSG 213
Cdd:cd22239    81 LLRIFKVSQEPPdTLVSQVKRLDLYHGTPRALLHPDLPIETNENIKV--VEGCQLLYTLRTHKALEKIFHLLPENVLVGG 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931246  214 FQQIPGLLPPHGDtgklpvdlttvdSGDALRKPRFQKPTTWHLDDLFFTLYPSLEKFEEELVQLLISDR--EGVGLLDSG 291
Cdd:cd22239   159 SDKIPGILPISSD------------SGLALTKPKLLKTFICYLDKIQITLPPSIEKFEEELCKLLNEDRlnKDGGDTDGN 226
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931246  292 TLEVLERRLHVCVHNGLGFVQRPQvvvlvpemdvaltrsasfsrkisassknssgnqaLVLRSHLRLPEMVSHPAFAIVF 371
Cdd:cd22239   227 SVIILERRLRVGVHNGWCYVQKPQ----------------------------------LVLRSRVQLPEMVQDPDFAVVF 272
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931246  372 QLEYVFNSPSGADGGASSptSISSVACMHMVRWAVWNPDLEVGPGKVTLPLQGGVQQNPSRCLVYKvpsasmsseevkqv 451
Cdd:cd22239   273 QLEYVFSVPVAASGRKAS--TLSSAAYMVLVRWAAWSPFSEGGSSEVTLPLRGGPSPNPDNLLVYK-------------- 336
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931246  452 esgtiqfqfslssdgptehangprvgrrssrkmpaspsgtpapaardlaatqdspvgpglslsqltasplspalqssskp 531
Cdd:cd22239       --------------------------------------------------------------------------------
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931246  532 plqppdssqspegpqlqaesvlesrvshleadlsqpaslqgtpavehlqelpftplhapivvgaqtrssrsqLSRAAMVL 611
Cdd:cd22239   337 ------------------------------------------------------------------------LSRAAYAR 344
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931246  612 LQSSGFPEILDASQQPVEAVNPIDPVRFNPQKEESDCLRGNEIVLQFLAFSRAAQDCPGTPWPQTVYFTFQFYRFPPETT 691
Cdd:cd22239   345 LYTSGFPEILDRNGEPAEVVDPSDPVNFDLQREEADPLQTNEIILQFLAFSRIAQDKSESRWPKSLFFTFQFYRFPPVTT 424
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931246  692 PrlqlvkldgtgksgsgslshilvpinkdgsfdagspGLQLRYMVDPGFLKPGEQRWFAHYLAAQTLQVDVWDGDSLLLI 771
Cdd:cd22239   425 E------------------------------------GLQLKYVVDPSFLKPGEARLFLQYLAVQTLHIDVWDGDSLLLI 468
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931246  772 GSAGVQMKHLLRQGRPAVQVSHELEVVAteyeqemmavsgdvagfgsvkpigvhtvvkgrlhltlanvghaceprargsn 851
Cdd:cd22239   469 GSAAVPLKHLLRQGRDAVQVSHELDVID---------------------------------------------------- 496
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931246  852 llppsrsrvisndgasffsggsllipggpkrkrvvqaqrladvdselaamllthtragqgpqaagqeadavhkRKLERMR 931
Cdd:cd22239   497 -------------------------------------------------------------------------RKLARMQ 503
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931246  932 LVRLQEAGGDSDSRRISLLAQHSVRAQHSRDLQVIDAYRERTKAESIAGVLSQAITTHHTLYATLGTAEFFEFALKNPHN 1011
Cdd:cd22239   504 AVRQQESPNEDPSFGNRVLAEKEERTQRTRDLQTIEAYRERTKREFILSMLSQAITTEHTIHPSFGTAEFFEFVLKNPYN 583
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931246 1012 TQHTVAIEIDSPELSIILDSQEWRYFKEATGLHTPLEEDMFHLRG-SLAPQLYLRPRETAHIPLKFQsfsvgplaptqap 1090
Cdd:cd22239   584 VQHTVTIEIDDPELSVITDAREWRYFKELNNVTTPLEENMFHLNPdTLRPQVFLRPKETVHIPFKYQ------------- 650
                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931246 1091 aevitekdaesgplwkcsamptkhakvlfrvetgqliavlcltvepqPHVVDQVFRFYHPELTFLKKAIRLPPWHTLPGA 1170
Cdd:cd22239   651 -----------------------------------------------PHVVDQTFRFYHPEQSFLKKSIRLPPFHTLPGA 683
                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931246 1171 PVGmPGEDPPVHVRCSDPNVICEAQNVGPGEPRDVFLKVASGPSPEIKDFFVVIYADRWLAVPVQTWQVCLHSLQRVDVS 1250
Cdd:cd22239   684 PVG-PGGLRQVHVRCSDPNVICETRNLTPGEPQDVFIKVASGPSPQIKKFFVLIYSDPYLARPIQIWQFYVHALQRVDVS 762
                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931246 1251 CVAGQLTRLSLVLRGTQTVRKVraftshpqelktdpagvfvlpphgvqdlhvgvrprraGSRFVHLNLVDIDYHQLVASW 1330
Cdd:cd22239   763 CVEGQTSRFSLVLRGTQSSRVV-------------------------------------GSKFLYVNVVDTETHQLVRSW 805
                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931246 1331 LVCLSCRQPLISKAFEITMAAGDEKGTNKRITYTNPYPSRRTYRLHSDRPELLRFKEDSFQVAGGETYTIGLRFLPSGSA 1410
Cdd:cd22239   806 LVCISCRQPVISKAFEIQLPVGGGKGCNKRISYTNPYPNRKTFHLRTNRSDLLQFKETRLEVGAGETYTIGLRFAPSQTP 885
                        1370
                  ....*....|....*....
gi 568931246 1411 GQEEILIYINDHEDKNEET 1429
Cdd:cd22239   886 GKEEILIFINDEEDKNEET 904
PHA03247 super family cl33720
large tegument protein UL36; Provisional
459-641 7.58e-04

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.16  E-value: 7.58e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931246  459 QFSLSSDGPTEHANGPRVGRRSSRKMPASPSGTPAPAARDLAATQDSPVGPGLSLSQLTASPLSPALQSSSKPPLQP--- 535
Cdd:PHA03247 2675 QASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPggp 2754
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931246  536 --PDSSQSPEGPqlQAESVLESRVSHLEADLSQPASLQGTPAVEHLqELPFTPLHAPIVVGAQTRSSRSQLSRAAMVLLQ 613
Cdd:PHA03247 2755 arPARPPTTAGP--PAPAPPAAPAAGPPRRLTRPAVASLSESRESL-PSPWDPADPPAAVLAPAAALPPAASPAGPLPPP 2831
                         170       180       190
                  ....*....|....*....|....*....|....*
gi 568931246  614 SSGFPEILDASQQPVE-------AVNPIDPVRFNP 641
Cdd:PHA03247 2832 TSAQPTAPPPPPGPPPpslplggSVAPGGDVRRRP 2866
 
Name Accession Description Interval E-value
NPHP4 cd22239
Nephrocystin-4; Nephrocystin-4 (NPHP4), also known as nephroretinin, is a component of the ...
55-1429 0e+00

Nephrocystin-4; Nephrocystin-4 (NPHP4), also known as nephroretinin, is a component of the nephronophthisis (NPHP) module which is part of the transition zone (TZ) of the cilia. NPHP4 forms complexes with alpha-tubulin, NPHP1 and RPGRIP1. The interaction with NPHP1 is crucial for cell-cell and cell-matrix adhesion signaling. Mutations in NPHP4 have been shown to cause nephronophthisis (NPHP), an autosomal recessive cause of kidney failure and earlier stages of chronic kidney disease among adults.


Pssm-ID: 412072  Cd Length: 904  Bit Score: 1222.57  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931246   55 ECHLRVTLFDVTYKHFFGRTWKTTVKPTNQPSKQPPRITFNEPLYFHTTLSHPSIVAVVEVVTEGRKRDGTLQLLSCGFG 134
Cdd:cd22239     1 EYQLRVSLFDSTYKHFFGRTWKSPSVTLKSSQGQKIKLLFNEPVYFHTSLNDPSIVAVVEVVAVEKDKDGIKNRTSCGWG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931246  135 ILRIFGNKPESP-TSAAQDKRLRLYHGTPRALLHPLLQDPIEQNKFMrlMENCSLQYTLKPHPPLEPAFHLLPENLLVSG 213
Cdd:cd22239    81 LLRIFKVSQEPPdTLVSQVKRLDLYHGTPRALLHPDLPIETNENIKV--VEGCQLLYTLRTHKALEKIFHLLPENVLVGG 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931246  214 FQQIPGLLPPHGDtgklpvdlttvdSGDALRKPRFQKPTTWHLDDLFFTLYPSLEKFEEELVQLLISDR--EGVGLLDSG 291
Cdd:cd22239   159 SDKIPGILPISSD------------SGLALTKPKLLKTFICYLDKIQITLPPSIEKFEEELCKLLNEDRlnKDGGDTDGN 226
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931246  292 TLEVLERRLHVCVHNGLGFVQRPQvvvlvpemdvaltrsasfsrkisassknssgnqaLVLRSHLRLPEMVSHPAFAIVF 371
Cdd:cd22239   227 SVIILERRLRVGVHNGWCYVQKPQ----------------------------------LVLRSRVQLPEMVQDPDFAVVF 272
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931246  372 QLEYVFNSPSGADGGASSptSISSVACMHMVRWAVWNPDLEVGPGKVTLPLQGGVQQNPSRCLVYKvpsasmsseevkqv 451
Cdd:cd22239   273 QLEYVFSVPVAASGRKAS--TLSSAAYMVLVRWAAWSPFSEGGSSEVTLPLRGGPSPNPDNLLVYK-------------- 336
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931246  452 esgtiqfqfslssdgptehangprvgrrssrkmpaspsgtpapaardlaatqdspvgpglslsqltasplspalqssskp 531
Cdd:cd22239       --------------------------------------------------------------------------------
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931246  532 plqppdssqspegpqlqaesvlesrvshleadlsqpaslqgtpavehlqelpftplhapivvgaqtrssrsqLSRAAMVL 611
Cdd:cd22239   337 ------------------------------------------------------------------------LSRAAYAR 344
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931246  612 LQSSGFPEILDASQQPVEAVNPIDPVRFNPQKEESDCLRGNEIVLQFLAFSRAAQDCPGTPWPQTVYFTFQFYRFPPETT 691
Cdd:cd22239   345 LYTSGFPEILDRNGEPAEVVDPSDPVNFDLQREEADPLQTNEIILQFLAFSRIAQDKSESRWPKSLFFTFQFYRFPPVTT 424
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931246  692 PrlqlvkldgtgksgsgslshilvpinkdgsfdagspGLQLRYMVDPGFLKPGEQRWFAHYLAAQTLQVDVWDGDSLLLI 771
Cdd:cd22239   425 E------------------------------------GLQLKYVVDPSFLKPGEARLFLQYLAVQTLHIDVWDGDSLLLI 468
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931246  772 GSAGVQMKHLLRQGRPAVQVSHELEVVAteyeqemmavsgdvagfgsvkpigvhtvvkgrlhltlanvghaceprargsn 851
Cdd:cd22239   469 GSAAVPLKHLLRQGRDAVQVSHELDVID---------------------------------------------------- 496
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931246  852 llppsrsrvisndgasffsggsllipggpkrkrvvqaqrladvdselaamllthtragqgpqaagqeadavhkRKLERMR 931
Cdd:cd22239   497 -------------------------------------------------------------------------RKLARMQ 503
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931246  932 LVRLQEAGGDSDSRRISLLAQHSVRAQHSRDLQVIDAYRERTKAESIAGVLSQAITTHHTLYATLGTAEFFEFALKNPHN 1011
Cdd:cd22239   504 AVRQQESPNEDPSFGNRVLAEKEERTQRTRDLQTIEAYRERTKREFILSMLSQAITTEHTIHPSFGTAEFFEFVLKNPYN 583
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931246 1012 TQHTVAIEIDSPELSIILDSQEWRYFKEATGLHTPLEEDMFHLRG-SLAPQLYLRPRETAHIPLKFQsfsvgplaptqap 1090
Cdd:cd22239   584 VQHTVTIEIDDPELSVITDAREWRYFKELNNVTTPLEENMFHLNPdTLRPQVFLRPKETVHIPFKYQ------------- 650
                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931246 1091 aevitekdaesgplwkcsamptkhakvlfrvetgqliavlcltvepqPHVVDQVFRFYHPELTFLKKAIRLPPWHTLPGA 1170
Cdd:cd22239   651 -----------------------------------------------PHVVDQTFRFYHPEQSFLKKSIRLPPFHTLPGA 683
                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931246 1171 PVGmPGEDPPVHVRCSDPNVICEAQNVGPGEPRDVFLKVASGPSPEIKDFFVVIYADRWLAVPVQTWQVCLHSLQRVDVS 1250
Cdd:cd22239   684 PVG-PGGLRQVHVRCSDPNVICETRNLTPGEPQDVFIKVASGPSPQIKKFFVLIYSDPYLARPIQIWQFYVHALQRVDVS 762
                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931246 1251 CVAGQLTRLSLVLRGTQTVRKVraftshpqelktdpagvfvlpphgvqdlhvgvrprraGSRFVHLNLVDIDYHQLVASW 1330
Cdd:cd22239   763 CVEGQTSRFSLVLRGTQSSRVV-------------------------------------GSKFLYVNVVDTETHQLVRSW 805
                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931246 1331 LVCLSCRQPLISKAFEITMAAGDEKGTNKRITYTNPYPSRRTYRLHSDRPELLRFKEDSFQVAGGETYTIGLRFLPSGSA 1410
Cdd:cd22239   806 LVCISCRQPVISKAFEIQLPVGGGKGCNKRISYTNPYPNRKTFHLRTNRSDLLQFKETRLEVGAGETYTIGLRFAPSQTP 885
                        1370
                  ....*....|....*....
gi 568931246 1411 GQEEILIYINDHEDKNEET 1429
Cdd:cd22239   886 GKEEILIFINDEEDKNEET 904
PHA03247 PHA03247
large tegument protein UL36; Provisional
459-641 7.58e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.16  E-value: 7.58e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931246  459 QFSLSSDGPTEHANGPRVGRRSSRKMPASPSGTPAPAARDLAATQDSPVGPGLSLSQLTASPLSPALQSSSKPPLQP--- 535
Cdd:PHA03247 2675 QASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPggp 2754
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931246  536 --PDSSQSPEGPqlQAESVLESRVSHLEADLSQPASLQGTPAVEHLqELPFTPLHAPIVVGAQTRSSRSQLSRAAMVLLQ 613
Cdd:PHA03247 2755 arPARPPTTAGP--PAPAPPAAPAAGPPRRLTRPAVASLSESRESL-PSPWDPADPPAAVLAPAAALPPAASPAGPLPPP 2831
                         170       180       190
                  ....*....|....*....|....*....|....*
gi 568931246  614 SSGFPEILDASQQPVE-------AVNPIDPVRFNP 641
Cdd:PHA03247 2832 TSAQPTAPPPPPGPPPpslplggSVAPGGDVRRRP 2866
DUF1631 pfam07793
Protein of unknown function (DUF1631); The members of this family are sequences derived from a ...
463-582 8.76e-03

Protein of unknown function (DUF1631); The members of this family are sequences derived from a group of hypothetical proteins expressed by certain bacterial species. The region concerned is approximately 440 amino acid residues in length.


Pssm-ID: 429661  Cd Length: 742  Bit Score: 40.77  E-value: 8.76e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931246   463 SSDGPTEHANGPRVGRRSSRKMPASPSGTPAPAARDLAATQDSPVGPGLSLSQLtaSPLSPALQSSSKPPLQPPDSSQSP 542
Cdd:pfam07793  217 QSRRASASPAGAAGGNPDSQAAPAAAATAPAGGAGAQGAAAAAPEGPGALFSAL--QQLLSAARSQRAPAAQAAGAPPAP 294
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 568931246   543 eGPQLQAESVLeSRVSHLE----ADLSQPASLQGTPAVEHLQEL 582
Cdd:pfam07793  295 -APALSSAELL-QALSRLQqgpaAEQAAGAGADIPDLRERLVNV 336
 
Name Accession Description Interval E-value
NPHP4 cd22239
Nephrocystin-4; Nephrocystin-4 (NPHP4), also known as nephroretinin, is a component of the ...
55-1429 0e+00

Nephrocystin-4; Nephrocystin-4 (NPHP4), also known as nephroretinin, is a component of the nephronophthisis (NPHP) module which is part of the transition zone (TZ) of the cilia. NPHP4 forms complexes with alpha-tubulin, NPHP1 and RPGRIP1. The interaction with NPHP1 is crucial for cell-cell and cell-matrix adhesion signaling. Mutations in NPHP4 have been shown to cause nephronophthisis (NPHP), an autosomal recessive cause of kidney failure and earlier stages of chronic kidney disease among adults.


Pssm-ID: 412072  Cd Length: 904  Bit Score: 1222.57  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931246   55 ECHLRVTLFDVTYKHFFGRTWKTTVKPTNQPSKQPPRITFNEPLYFHTTLSHPSIVAVVEVVTEGRKRDGTLQLLSCGFG 134
Cdd:cd22239     1 EYQLRVSLFDSTYKHFFGRTWKSPSVTLKSSQGQKIKLLFNEPVYFHTSLNDPSIVAVVEVVAVEKDKDGIKNRTSCGWG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931246  135 ILRIFGNKPESP-TSAAQDKRLRLYHGTPRALLHPLLQDPIEQNKFMrlMENCSLQYTLKPHPPLEPAFHLLPENLLVSG 213
Cdd:cd22239    81 LLRIFKVSQEPPdTLVSQVKRLDLYHGTPRALLHPDLPIETNENIKV--VEGCQLLYTLRTHKALEKIFHLLPENVLVGG 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931246  214 FQQIPGLLPPHGDtgklpvdlttvdSGDALRKPRFQKPTTWHLDDLFFTLYPSLEKFEEELVQLLISDR--EGVGLLDSG 291
Cdd:cd22239   159 SDKIPGILPISSD------------SGLALTKPKLLKTFICYLDKIQITLPPSIEKFEEELCKLLNEDRlnKDGGDTDGN 226
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931246  292 TLEVLERRLHVCVHNGLGFVQRPQvvvlvpemdvaltrsasfsrkisassknssgnqaLVLRSHLRLPEMVSHPAFAIVF 371
Cdd:cd22239   227 SVIILERRLRVGVHNGWCYVQKPQ----------------------------------LVLRSRVQLPEMVQDPDFAVVF 272
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931246  372 QLEYVFNSPSGADGGASSptSISSVACMHMVRWAVWNPDLEVGPGKVTLPLQGGVQQNPSRCLVYKvpsasmsseevkqv 451
Cdd:cd22239   273 QLEYVFSVPVAASGRKAS--TLSSAAYMVLVRWAAWSPFSEGGSSEVTLPLRGGPSPNPDNLLVYK-------------- 336
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931246  452 esgtiqfqfslssdgptehangprvgrrssrkmpaspsgtpapaardlaatqdspvgpglslsqltasplspalqssskp 531
Cdd:cd22239       --------------------------------------------------------------------------------
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931246  532 plqppdssqspegpqlqaesvlesrvshleadlsqpaslqgtpavehlqelpftplhapivvgaqtrssrsqLSRAAMVL 611
Cdd:cd22239   337 ------------------------------------------------------------------------LSRAAYAR 344
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931246  612 LQSSGFPEILDASQQPVEAVNPIDPVRFNPQKEESDCLRGNEIVLQFLAFSRAAQDCPGTPWPQTVYFTFQFYRFPPETT 691
Cdd:cd22239   345 LYTSGFPEILDRNGEPAEVVDPSDPVNFDLQREEADPLQTNEIILQFLAFSRIAQDKSESRWPKSLFFTFQFYRFPPVTT 424
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931246  692 PrlqlvkldgtgksgsgslshilvpinkdgsfdagspGLQLRYMVDPGFLKPGEQRWFAHYLAAQTLQVDVWDGDSLLLI 771
Cdd:cd22239   425 E------------------------------------GLQLKYVVDPSFLKPGEARLFLQYLAVQTLHIDVWDGDSLLLI 468
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931246  772 GSAGVQMKHLLRQGRPAVQVSHELEVVAteyeqemmavsgdvagfgsvkpigvhtvvkgrlhltlanvghaceprargsn 851
Cdd:cd22239   469 GSAAVPLKHLLRQGRDAVQVSHELDVID---------------------------------------------------- 496
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931246  852 llppsrsrvisndgasffsggsllipggpkrkrvvqaqrladvdselaamllthtragqgpqaagqeadavhkRKLERMR 931
Cdd:cd22239   497 -------------------------------------------------------------------------RKLARMQ 503
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931246  932 LVRLQEAGGDSDSRRISLLAQHSVRAQHSRDLQVIDAYRERTKAESIAGVLSQAITTHHTLYATLGTAEFFEFALKNPHN 1011
Cdd:cd22239   504 AVRQQESPNEDPSFGNRVLAEKEERTQRTRDLQTIEAYRERTKREFILSMLSQAITTEHTIHPSFGTAEFFEFVLKNPYN 583
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931246 1012 TQHTVAIEIDSPELSIILDSQEWRYFKEATGLHTPLEEDMFHLRG-SLAPQLYLRPRETAHIPLKFQsfsvgplaptqap 1090
Cdd:cd22239   584 VQHTVTIEIDDPELSVITDAREWRYFKELNNVTTPLEENMFHLNPdTLRPQVFLRPKETVHIPFKYQ------------- 650
                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931246 1091 aevitekdaesgplwkcsamptkhakvlfrvetgqliavlcltvepqPHVVDQVFRFYHPELTFLKKAIRLPPWHTLPGA 1170
Cdd:cd22239   651 -----------------------------------------------PHVVDQTFRFYHPEQSFLKKSIRLPPFHTLPGA 683
                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931246 1171 PVGmPGEDPPVHVRCSDPNVICEAQNVGPGEPRDVFLKVASGPSPEIKDFFVVIYADRWLAVPVQTWQVCLHSLQRVDVS 1250
Cdd:cd22239   684 PVG-PGGLRQVHVRCSDPNVICETRNLTPGEPQDVFIKVASGPSPQIKKFFVLIYSDPYLARPIQIWQFYVHALQRVDVS 762
                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931246 1251 CVAGQLTRLSLVLRGTQTVRKVraftshpqelktdpagvfvlpphgvqdlhvgvrprraGSRFVHLNLVDIDYHQLVASW 1330
Cdd:cd22239   763 CVEGQTSRFSLVLRGTQSSRVV-------------------------------------GSKFLYVNVVDTETHQLVRSW 805
                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931246 1331 LVCLSCRQPLISKAFEITMAAGDEKGTNKRITYTNPYPSRRTYRLHSDRPELLRFKEDSFQVAGGETYTIGLRFLPSGSA 1410
Cdd:cd22239   806 LVCISCRQPVISKAFEIQLPVGGGKGCNKRISYTNPYPNRKTFHLRTNRSDLLQFKETRLEVGAGETYTIGLRFAPSQTP 885
                        1370
                  ....*....|....*....
gi 568931246 1411 GQEEILIYINDHEDKNEET 1429
Cdd:cd22239   886 GKEEILIFINDEEDKNEET 904
PHA03247 PHA03247
large tegument protein UL36; Provisional
459-641 7.58e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.16  E-value: 7.58e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931246  459 QFSLSSDGPTEHANGPRVGRRSSRKMPASPSGTPAPAARDLAATQDSPVGPGLSLSQLTASPLSPALQSSSKPPLQP--- 535
Cdd:PHA03247 2675 QASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPggp 2754
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931246  536 --PDSSQSPEGPqlQAESVLESRVSHLEADLSQPASLQGTPAVEHLqELPFTPLHAPIVVGAQTRSSRSQLSRAAMVLLQ 613
Cdd:PHA03247 2755 arPARPPTTAGP--PAPAPPAAPAAGPPRRLTRPAVASLSESRESL-PSPWDPADPPAAVLAPAAALPPAASPAGPLPPP 2831
                         170       180       190
                  ....*....|....*....|....*....|....*
gi 568931246  614 SSGFPEILDASQQPVE-------AVNPIDPVRFNP 641
Cdd:PHA03247 2832 TSAQPTAPPPPPGPPPpslplggSVAPGGDVRRRP 2866
DUF1631 pfam07793
Protein of unknown function (DUF1631); The members of this family are sequences derived from a ...
463-582 8.76e-03

Protein of unknown function (DUF1631); The members of this family are sequences derived from a group of hypothetical proteins expressed by certain bacterial species. The region concerned is approximately 440 amino acid residues in length.


Pssm-ID: 429661  Cd Length: 742  Bit Score: 40.77  E-value: 8.76e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931246   463 SSDGPTEHANGPRVGRRSSRKMPASPSGTPAPAARDLAATQDSPVGPGLSLSQLtaSPLSPALQSSSKPPLQPPDSSQSP 542
Cdd:pfam07793  217 QSRRASASPAGAAGGNPDSQAAPAAAATAPAGGAGAQGAAAAAPEGPGALFSAL--QQLLSAARSQRAPAAQAAGAPPAP 294
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 568931246   543 eGPQLQAESVLeSRVSHLE----ADLSQPASLQGTPAVEHLQEL 582
Cdd:pfam07793  295 -APALSSAELL-QALSRLQqgpaAEQAAGAGADIPDLRERLVNV 336
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH