Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.

                          10        20
                  ....*....|....*....|...
gi 568946318  350 YSCSVCGKRFSLKHQMETHYRVH 372
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946318   23 RLRPALCDTLITVGGLEFPAHSLVLAGASPRL---------GCRGRWALVEDISPSTFAQILTFVYGESIeLQPGELGDL 93
Cdd:pfam00651   5 REQGELCDVTLVVGDKEFRAHKAVLAACSPYFkalfsgqesESSVSEITLDDVSPEDFEALLEFMYTGKL-ISEENVDDL 83

                          90
                  ....*....|....*.
gi 568946318   94 EEAAKALGVQALEEAC 109
Cdd:pfam00651  84 LAAADKLQIPSLVDKC 99

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.

                          10        20
                  ....*....|....*....|...
gi 568946318  350 YSCSVCGKRFSLKHQMETHYRVH 372
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946318  28 LCDTLITVGGLEFPAHSLVLAGASPRL----------GCRGRWALvEDISPSTFAQILTFVYGESIELQPGELGDLEEAA 97
Cdd:cd18186    1 LCDVTLVVGGREFPAHRAVLAARSPYFramfssgmkeSSSSEIEL-DDVSPEAFEALLDYIYTGELELSEENVEELLAAA 79

                 ...
gi 568946318  98 KAL 100
Cdd:cd18186   80 DKL 82

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946318   23 RLRPALCDTLITVGGLEFPAHSLVLAGASPRL---------GCRGRWALVEDISPSTFAQILTFVYGESIeLQPGELGDL 93
Cdd:pfam00651   5 REQGELCDVTLVVGDKEFRAHKAVLAACSPYFkalfsgqesESSVSEITLDDVSPEDFEALLEFMYTGKL-ISEENVDDL 83

                          90
                  ....*....|....*.
gi 568946318   94 EEAAKALGVQALEEAC 109
Cdd:pfam00651  84 LAAADKLQIPSLVDKC 99

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946318  28 LCDTLITVGGLEFPAHSLVLAGASPRL---------GCRGRWALVEDISPSTFAQILTFVYGESIELQPGELGDLEEAAK 98
Cdd:cd18306   18 FCDVILQVGGHEIPAHRAVLACASPYLfelfssdsdGESILTVKLDGLDPDAVEVLVNYAYTSRLEVPADLVKSVYSAAK 97

                         90
                 ....*....|.
gi 568946318  99 ALGVQALEEAC 109
Cdd:cd18306   98 KLKMDRVKKAC 108

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 38 (ZBTB38); ZBTB38, also termed CIBZ, is a transcriptional regulator with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3', as well as E-box elements (5'-CACGTG-3'). It can also bind specifically to a single methyl-CpG pair. ZBTB38 represses transcription in a methyl-CpG-dependent manner. It is a negative regulator of endoplasmic reticulum stress-associated apoptosis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946318  23 RLRPALCDTLITVGGLEFPAHSLVLAGAS---------PRLGCRGRWALVEDISPSTFAQILTFVYGESIEL-QPGELGD 92
Cdd:cd18223   13 RIQGILCDVTIVVEDTKFKAHKNVLAASSlyfknafssQEIWISSHVLELPDLKAEVFAEILNFIYSSKVVVkRQETVTD 92

                         90
                 ....*....|....
gi 568946318  93 LEEAAKALGVQALE 106
Cdd:cd18223   93 LVAAGKKLGITFLE 106

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946318  28 LCDTLITVGGLEFPAHSLVLAGASPRLG--------CRGRWALVEDISPSTFAQILTFVYGESIELQPGELGDLEEAAKA 99
Cdd:cd18315    1 LVDVTLACEGGSLKAHKLVLAAASPYFAallketppDEHPVIILPDVPYSELKALLDFIYTGEVNVSQEQLESLLKLAEL 80

                 ...
gi 568946318 100 LGV 102
Cdd:cd18315   81 LQI 83

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 10 (KLHL10); KLHL10 is a substrate-specific adaptor of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins specifically in the testis during spermatogenesis. Haploinsufficiency of Klhl10 causes infertility in male mice. KLHL10 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946318  21 AARLRPALCDTLITVGGLEFPAHSLVLAGASP--RLGCRGRWA-------LVEDISPSTFAQILTFVYGESIELQPGELG 91
Cdd:cd18240   10 ELRLEGKLCDVVIRVNGVEFPAHRNILCACSPyfRALFTNGWNetekkvyKIPGVSPEMMELIIEYAYTRTVPITAENVE 89

                         90
                 ....*....|....*...
gi 568946318  92 DLEEAAKALGVQALEEAC 109
Cdd:cd18240   90 ELLPAADQFNIMGIVKAC 107

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37); ZBTB37 may be involved in transcriptional regulation. It is differentially expressed in aryl hydrocarbon receptor (AhR)-KO mice compared with WT mice, and may potentially contribute to the aging phenotype of AhR-KO mice. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946318  23 RLRPALCDTLITVGGLEFPAHSLVLAGASPRLgcRGRWALVE----DIS----PSTFAQILTFVYGESIELQPGELGDLE 94
Cdd:cd18222   20 RMQGRLCDIVVNVQGQSFRAHKVVLAASSPYF--RDHMSLNEmstvSISviknPTVFEQLLSFCYTGRICLQLADIISYL 97

                         90       100
                 ....*....|....*....|.
gi 568946318  95 EAAKALGVQALEEACQRAQKG 115
Cdd:cd18222   98 TAASFLQMQHIIDKCTQILEG 118

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 41 (ZBTB41); ZBTB41, also called FRBZ1, may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946318  15 DRLVQlaarlrPALCDTLITVGGLEFPAHSLVLA-GASPRLGCRGR-----WALVEDISPSTFAQILTFVYGESIELQPG 88
Cdd:cd18226   15 DRQKQ------SSFCDLVITVEGKEFSAHKVVVAvGSSYFHACLSKnpntdAVTLDHVSYSVFQHLLEFLYTSEFFVYEN 88

                         90
                 ....*....|....
gi 568946318  89 ELGDLEEAAKALGV 102
Cdd:cd18226   89 EIPLVLEAAKFLDI 102

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog (BACH) proteins; This subfamily includes BACH1 (also called BTB-basic leucine zipper transcription factor 1), BACH2 (also called BTB-basic leucine zipper transcription factor 2), and similar proteins. They belong to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). Subfamily members contain a BTB domain and a basic leucine zipper (bZIP) domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946318  28 LCDTLITVGGLEFPAHSLVLAGASPRLGCRGRW--------ALVEDISPSTFAQILTFVYGESIELQPGELGDLEEAAKA 99
Cdd:cd18955    1 LCDVTIVVEDQRFRAHRAVLAACSDYFLSRVVGqtdgdlviTLPEEVTVKGFEPLLQFAYTAKLLLSKENVLEVCRCAEF 80

                         90
                 ....*....|
gi 568946318 100 LGVQALEEAC 109
Cdd:cd18955   81 LGVHNIEKAC 90

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7 (ZBTB7); There are three ZBTB7 isoforms: ZBTB7A, ZBTB7B, and ZBTB7C. ZBTB7A is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. ZBTB7B is a transcriptional regulator of extracellular matrix gene expression. ZBTB7C is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. ZBTB7 isoforms contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946318  28 LCDTLITVGGLEFPAHSLVLAGASPRL------GCRGRWALVEDI---SPSTFAQILTFVYGESIELQPGELGDLEEAAK 98
Cdd:cd18198   25 LCDVVILVQGREYRTHRSVLAACSQYFkklftsGAVVDQQNVYEIdfvSPEALTALLEFAYTATLTVSTANVGDILSAAR 104

                         90
                 ....*....|.
gi 568946318  99 ALGVQALEEAC 109
Cdd:cd18198  105 LLEIPCVSHVC 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in rabankyrin-5 (Rank-5); Rank-5, also called ankyrin repeat and FYVE domain-containing protein 1 (ANKFY1) or ankyrin repeats hooked to a zinc finger motif (ANKHZN), is a Rab5 effector that regulates and coordinates different endocytic mechanisms. It contains an N-terminal BTB domain, followed by a BACK domain, several ankyrin (ANK) repeats and a C-terminal FYVE domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946318  16 RLVQLAARL--RPALCDTLITVGGLEFPAHSLVLAGAS----PRLGCRGRWALVEDISPSTFAQILTFVYGESIELQ--P 87
Cdd:cd18303    4 RLLKTVASLfdKELYSDITIKLADKSIPAHKFVLAARSekwsNENLASTNELDLSDISYEVVLALLRWLYTDELDLTldD 83

                         90       100
                 ....*....|....*....|....*
gi 568946318  88 GELGDLEEAAKALGVQALEEACQRA 112
Cdd:cd18303   84 EFLLELMKAAKRFQLTDLVERCERA 108

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946318  28 LCDTLITVGGLEFPAHSLVLAGASP--------RLG-CRGRWALVEDISPSTFAQILTFVYGESIELQPGELGDLEEAAK 98
Cdd:cd18238   15 LCDVTLKVGEKSIHCHRLVLACVSPyframftsEMAeSKQDSITIKDIDEEAVELLVDFAYTGKLTLTVDNVQSLLYAAS 94

                         90       100
                 ....*....|....*....|....*
gi 568946318  99 ALGVQALEEACQRAQKgkdeDELDP 123
Cdd:cd18238   95 LLQVEEVAKACCEFMK----DHLHP 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5 (KBTBD5) or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy. KLHL40 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946318  30 DTLITVGGLEFPAHSLVLAGASPRLGC---------RGRWALVEDISPSTFAQILTFVYGESIELQPGELGDLEEAAKAL 100
Cdd:cd18340   29 DCVLKIKEKEFPCHRLVLAACSPYFRAmflsdleesKKREIVLEDVDPDVMGKILHYIYTSEIEITEQNVQDIFAAANMF 108

                 ....*....
gi 568946318 101 GVQALEEAC 109
Cdd:cd18340  109 QIPSIFTVC 117

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 35 (KLHL35); KLHL35 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Significant differences in DNA methylation of the KLHL35 gene in abdominal aortic aneurysm (AAA) patients compared to non-AAA controls suggest a potential role in AAA pathology. Hypermethylation of the KLHL35 gene has also been associated with the development of hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946318  28 LCDTLITVGGLEFPAHSLVLAGASP---------RLGCRGRWALVEDISPSTFAQILTFVYGESIELQPGELGDLEEAAK 98
Cdd:cd18265   23 FTDVVLLVDGKDFPCHRATLSANSAyframfgghLKESRQAVVEIQKVSAAAMEVLLDYMYGGGLRIQEDNVESVLEASD 102

                         90
                 ....*....|...
gi 568946318  99 ALGVQALEEACQR 111
Cdd:cd18265  103 LLQVSKLREACVR 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also called actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GLUR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in actin-based neuronal function. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946318  23 RLRPALCDTLITVGGLEFPAHSLVLAGASPR---------LGCRGRWALVEDISPSTFAQILTFVYGESIELQPGELGDL 93
Cdd:cd18246   34 RQRGLLCDIVLHVGTKEIKAHKVVLASCSPYfhamftnemSESRQTHVTLHDIDPQALEQLVQYAYTAEIVVGEGNVQTL 113

                         90
                 ....*....|....*.
gi 568946318  94 EEAAKALGVQALEEAC 109
Cdd:cd18246  114 LPAASLLQLNGVRDAC 129

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in myoneurin; Myoneurin, also called zinc finger and BTB domain-containing protein 31 (ZBTB31), is a novel member of the BTB/POZ-zinc finger family highly expressed in the neuromuscular system and is associated with neuromuscular junctions during the late embryonic period. It may function as a synaptic gene regulator. Myoneurin contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946318  28 LCDTLITVGGLEFPAHSLVLAGASPRLGCRGRWAL-------VEDISPSTFAQILTFVYGESIELQPGELGDLEEAAKAL 100
Cdd:cd18217   18 LCDCTIVIGQFQFKAHRNVLAAFSEYFGAQYKDTEdnivfldQSQVSADGFQKLLEFIYTGNLNLDSWNVAEIHQAASYL 97

                         90
                 ....*....|
gi 568946318 101 GVQALEEACQ 110
Cdd:cd18217   98 GMEEVVAKCK 107

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL40 and KLHL41; This family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568946318  30 DTLITVGGLEFPAHSLVLAGASPRLGC---------RGRWALVEDISPSTFAQILTFVYGESIELQPGELGDLEEAA 97
Cdd:cd18269   29 DCVLKIGDKEFPCHRLVLAACSPYFRAmflsdleesKKKEVVLEDVDPDVMGMILKYLYTSEIDLNDQNVQDIFALA 105

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6) or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946318  14 SDRLVQLAARLRPALC--DTLITVGGLEFPAHSLVLAGASP---RLGCRG----RWALVE--DISPSTFAQILTFVYGES 82
Cdd:cd18253    2 SESILQVFNEFRDSRLftDVIICVEGREFPCHRAILSACSSyfrAMFCNDhresREMLVEinGILAEAMDCFLQYVYTGK 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 568946318  83 IELQPGELGDLEEAAKALGVQALEEACQRAQkgkdEDELDPG 124
Cdd:cd18253   82 VKITTENVQYLFETSSLFQISPLRDACAKFL----EEQLDPC 119

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946318  30 DTLITVGGLEFPAHSLVLAGASP---------RLGCRGRWALVEDISPSTFAQILTFVYGESIELQPGELGDLEEAAKAL 100
Cdd:cd18314    8 DVVLCVGDRKFFAHRIVLCARSPvfrsmltgsMIESNLKEVTLEDVEPEIFETVLKYMYTGQVTLSEENVLDLLMLASKY 87

                 ....*....
gi 568946318 101 GVQALEEAC 109
Cdd:cd18314   88 QVPDLEKLC 96

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946318  23 RLRPALCDTLITVGGLEFPAHSLVLAGASPRLGC-------RGRWALVE--DISPSTFAQILTFVYGESIELQPGELGDL 93
Cdd:cd18237   16 RKQKTLCDVILIVEGREIKAHRVVLAAASHFFHLmftsnmtESKSSEVElkDAEPDIIELLVEFAYTARISVNSNNVQSL 95

                         90
                 ....*....|....*.
gi 568946318  94 EEAAKALGVQALEEAC 109
Cdd:cd18237   96 LDAANQYQIEPVKKMC 111

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 30 (KLHL30); KLHL30 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946318  23 RLRPALCDTLITVGGLEFPAHSLVLAGASPRLGCRGRWALVEDIS---------PSTFAQILTFVYGESIELQPGELGDL 93
Cdd:cd18259   27 RSNPKLSDVTLLVGGREFPCHRSVLALCSHYFNAMFTGDFVESISarveikdvdPAVMESLIDFAYTGKLTINQGNVEAL 106

                         90
                 ....*....|....*...
gi 568946318  94 EEAAKALGVQALEEACQR 111
Cdd:cd18259  107 IRTSNRLQFPTVRKVCSR 124

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 1 (BACH1); BACH1, also called BTB-basic leucine zipper transcription factor 1, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. It can act as repressor or activator. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. It is also a negative regulator of nuclear factor erythroid 2-related factor 2 (Nrf2) that controls antioxidant response elements (ARE)-dependent gene expressions. BACH1 binds to NF-E2 binding sites in vitro, and plays important roles in coordinating transcription activation and repression by MafK. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946318  23 RLRPALCDTLITVGGLEFPAHSLVLAGASPRLGCR--GRW------ALVEDISPSTFAQILTFVYGESIELQPGELGDLE 94
Cdd:cd18277   22 RKKDVLCDVTILVEGQRFRAHRSVLAACSSYFHSRivGQAdaelniTLPEEVTVKGFEPLIQFAYTAKLILSKDNVDEVC 101

                         90
                 ....*....|....*
gi 568946318  95 EAAKALGVQALEEAC 109
Cdd:cd18277  102 KCVEFLSVHNIEESC 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins; This family includes speckle-type POZ protein (SPOP), speckle-type POZ protein-like (SPOPL), TD and POZ domain-containing proteins (TDPOZ), Drosophila melanogaster protein roadkill and similar proteins. Both, SPOP and SPOPL, serve as adaptors of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and proteasomal degradation of target proteins. TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domains. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946318  30 DTLITVGGLEFPAHSLVLAGASPRLGC----------RGRWAlVEDISPSTFAQILTFVY-GESIELQpGELGDLEEAAK 98
Cdd:cd18279   20 DCCLCVGGQEFQAHKAILAARSPVFSAmfehemeeskKNRVE-INDVDPEVFKEMMRFIYtGKAPNLD-KMADDLLAAAD 97

                         90
                 ....*....|....
gi 568946318  99 ALGVQALEEACQRA 112
Cdd:cd18279   98 KYALERLKVMCEDA 111

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 4 (KBTBD4); KBTBD4, also called BTB and kelch domain-containing protein 4 (BKLHD4), is a BTB-BACK-Kelch domain protein belonging to a large family of cullin-RING ubiquitin ligase adaptors that facilitate the ubiquitination of target substrates. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946318  30 DTLITVGGLEFPAHSLVLAG---------ASPRLGCRGRWALVEDISPSTFAQILTFVYGESIELQPGELGDLEEAAKAL 100
Cdd:cd18272   34 DVTISVEGKEFQLHRLVLSAqscffrsmfTSNLKEARNRVIELKDVSESVFQLLVDYIYHGTVKLRVEELQETYEVADMY 113

                         90
                 ....*....|.
gi 568946318 101 GVQALEEACQR 111
Cdd:cd18272  114 QLTALFEECSR 124

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 1 protein (Hic-1); Hic-1, also called zinc finger and BTB domain-containing protein 29 (ZBTB29), is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. It may act as a tumor suppressor, and is involved in regulatory loops modulating P53-dependent and E2F1-dependent cell survival, growth control, and stress responses. It also regulates intestinal immunity and homeostasis. Hic-1 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946318  17 LVQL-AARLRPALCDTLITVGGLEFPAHSLVLAGASPRLgcrgRWALVED---------ISPSTFAQILTFVY-GESIEL 85
Cdd:cd18333    9 LLQLnTQRTKGFLCDVIIVVQNALFRAHKNILAASSVYL----KSLVVHDnlinldhemVSPGIFRLILDYIYtGRLSEG 84

                         90       100       110
                 ....*....|....*....|....*....|..
gi 568946318  86 QPG---ELGDLEEAAKALGVQALEEACQRAQK 114
Cdd:cd18333   85 DPGseqNLGAVLAAASYLQIPDLVALCKKKLK 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in plant BTB/POZ-MATH (BPM) protein family; The BPM protein family includes Arabidopsis thaliana BTB/POZ and MATH domain-containing proteins, AtBPM1-6, and similar proteins from other plants. BPM protein, also called protein BTB-POZ and MATH domain, may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946318  29 CDTLITVGGLEFPAHSLVLAGASPRL---------GCRGRWALVEDISPSTFAQILTFVYGESI-ELQPGELGDLEEAAK 98
Cdd:cd18280   15 ADVTFNVDGEKFRAHKLVLAARSPVFrsmlfgpmrEENEGEIVIEDVEPPVFKALLHFIYKDELpDDVEPAGSDSSSLDT 94

                         90
                 ....*....|
gi 568946318  99 ALGVQALEEA 108
Cdd:cd18280   95 TMAQHLLAAA 104

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946318  30 DTLITVGGLEFPAHSLVLAGASP----RLGCRGRWALVE-----DISPSTFAQILTFVYGESIELQPGELGDLEEAAKAL 100
Cdd:cd18250   23 DVTLCAGGREFPCHRTVLAAASSyfraMFAGELRESRADrvvlhGVSAEILGLLLDFSYTGRVTVTQDNVEALLRAADLF 102

                 ....*....
gi 568946318 101 GVQALEEAC 109
Cdd:cd18250  103 QFPSVKEAC 111

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946318  26 PALCDTLITVGGLEFPAHSLVLAGASPRL-------GCRGRWALVE--DISPSTFAQILTFVYG---ESIELQPGELGDL 93
Cdd:cd18297   10 PEMSDVTFLVEGRPFYAHKIVLVTASDRFksmlssgSTEAQTPVIEipDIRYDIFQLMMQYLYTggvESLDVAQDDALEL 89

                         90
                 ....*....|....*....
gi 568946318  94 EEAAKALGVQALEEACQRA 112
Cdd:cd18297   90 LRAASFFQLDGLKRHCEIL 108