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Conserved domains on  [gi|578805879|ref|XP_006713131|]
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glycerol-3-phosphate dehydrogenase 1-like protein isoform X1 [Homo sapiens]

Protein Classification

glycerol-3-phosphate dehydrogenase family protein( domain architecture ID 11496765)

glycerol-3-phosphate dehydrogenase family protein is similar to human L-alpha-glycerol-3-phosphate dehydrogenase 1 (GPD1), which catalyzes the reversible biological conversion of dihydroxyacetone (DHAP) to glycerol-3-phosphate

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
glycerol3P_DH TIGR03376
glycerol-3-phosphate dehydrogenase (NAD(+)); Members of this protein family are the eukaryotic ...
 7-297 6.67e-151

glycerol-3-phosphate dehydrogenase (NAD(+)); Members of this protein family are the eukaryotic enzyme, glycerol-3-phosphate dehydrogenase (NAD(+)) (EC 1.1.1.8). Enzymatic activity for 1.1.1.8 is defined as sn-glycerol 3-phosphate + NAD(+) = glycerone phosphate + NADH. Note the very similar reactions of enzymes defined as EC 1.1.1.94 and 1.1.99.5, assigned to families of proteins in the bacteria.


:

Pssm-ID: 274551 [Multi-domain]  Cd Length: 342  Bit Score: 426.37  E-value: 6.67e-151
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578805879    7 KVCIVGSGNWGSAVAKIIGNNVKKL-QKFASTVKMWVFEETVNGRKLTDIINNDHENVKYLPGHKLPENV---------- 75
Cdd:TIGR03376   1 RVAVVGSGNWGTAIAKIVAENARALpELFEESVRMWVFEEEIEGRNLTEIINTTHENVKYLPGIKLPANLvavpdlveaa 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578805879   76 -------------------------------------GIDEGPEGLKLISDIIREKMGIDISVLMGANIANEVAAEKFCE 118
Cdd:TIGR03376  81 kgadilvfviphqflegickqlkghvkpnaraiscikGLEVSKDGVKLLSDIIEEELGIPCGVLSGANLANEVAKEKFSE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578805879  119 TTIGSKVMEN----GLLFKELLQTPNFRITVVDDADTVELCGALKNIVAVGAGFCDGLRCGDNTKAAVIRLGLMEMIAFA 194
Cdd:TIGR03376 161 TTVGYRDPADfdvdARVLKALFHRPYFRVNVVDDVAGVEIAGALKNVVAIAAGFVDGLGWGDNAKAAVMRRGLLEMIKFA 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578805879  195 RIFCKGQVSTATFlESCGVADLITTCYGGRNRRVAEAFARTGKTIEELEKEMLNGQKLQGPQTSAEVYRILKQKGLLDKF 274
Cdd:TIGR03376 241 RMFFPTGEVTFTF-ESCGVADLITTCLGGRNFKVGRAFAKTGKSLEELEKELLNGQSLQGVATAKEVHELLKNKNKDDEF 319

                         330       340
                  ....*....|....*....|...
gi 578805879  275 PLFTAVYQICYESRPVQEMLSCL 297
Cdd:TIGR03376 320 PLFEAVYQILYEGLPPKKLPECL 342
 
Name Accession Description Interval E-value
glycerol3P_DH TIGR03376
glycerol-3-phosphate dehydrogenase (NAD(+)); Members of this protein family are the eukaryotic ...
 7-297 6.67e-151

glycerol-3-phosphate dehydrogenase (NAD(+)); Members of this protein family are the eukaryotic enzyme, glycerol-3-phosphate dehydrogenase (NAD(+)) (EC 1.1.1.8). Enzymatic activity for 1.1.1.8 is defined as sn-glycerol 3-phosphate + NAD(+) = glycerone phosphate + NADH. Note the very similar reactions of enzymes defined as EC 1.1.1.94 and 1.1.99.5, assigned to families of proteins in the bacteria.


Pssm-ID: 274551 [Multi-domain]  Cd Length: 342  Bit Score: 426.37  E-value: 6.67e-151
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578805879    7 KVCIVGSGNWGSAVAKIIGNNVKKL-QKFASTVKMWVFEETVNGRKLTDIINNDHENVKYLPGHKLPENV---------- 75
Cdd:TIGR03376   1 RVAVVGSGNWGTAIAKIVAENARALpELFEESVRMWVFEEEIEGRNLTEIINTTHENVKYLPGIKLPANLvavpdlveaa 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578805879   76 -------------------------------------GIDEGPEGLKLISDIIREKMGIDISVLMGANIANEVAAEKFCE 118
Cdd:TIGR03376  81 kgadilvfviphqflegickqlkghvkpnaraiscikGLEVSKDGVKLLSDIIEEELGIPCGVLSGANLANEVAKEKFSE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578805879  119 TTIGSKVMEN----GLLFKELLQTPNFRITVVDDADTVELCGALKNIVAVGAGFCDGLRCGDNTKAAVIRLGLMEMIAFA 194
Cdd:TIGR03376 161 TTVGYRDPADfdvdARVLKALFHRPYFRVNVVDDVAGVEIAGALKNVVAIAAGFVDGLGWGDNAKAAVMRRGLLEMIKFA 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578805879  195 RIFCKGQVSTATFlESCGVADLITTCYGGRNRRVAEAFARTGKTIEELEKEMLNGQKLQGPQTSAEVYRILKQKGLLDKF 274
Cdd:TIGR03376 241 RMFFPTGEVTFTF-ESCGVADLITTCLGGRNFKVGRAFAKTGKSLEELEKELLNGQSLQGVATAKEVHELLKNKNKDDEF 319

                         330       340
                  ....*....|....*....|...
gi 578805879  275 PLFTAVYQICYESRPVQEMLSCL 297
Cdd:TIGR03376 320 PLFEAVYQILYEGLPPKKLPECL 342
PTZ00345 PTZ00345
glycerol-3-phosphate dehydrogenase; Provisional
 3-297 8.00e-131

glycerol-3-phosphate dehydrogenase; Provisional


Pssm-ID: 240373 [Multi-domain]  Cd Length: 365  Bit Score: 376.28  E-value: 8.00e-131
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578805879   3 AAPLKVCIVGSGNWGSAVAKIIGNNVKKLQKFASTVKMWVFEETVNGRKLTDIINNDHENVKYLPGHKLPENV------- 75
Cdd:PTZ00345   9 CGPLKVSVIGSGNWGSAISKVVGENTQRNYIFHNEVRMWVLEEIVEGEKLSDIINTKHENVKYLPGIKLPDNIvavsdlk 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578805879  76 -------------------------------------------GIDEGPEgLKLISDIIREKMGIDISVLMGANIANEVA 112
Cdd:PTZ00345  89 eavedadllifviphqflesvlsqikennnlkkharaisltkgIIVENGK-PVLCSDVIEEELGIPCCALSGANVANDVA 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578805879 113 AEKFCETTIGSKVMENGLLFKELLQTPNFRITVVDDADTVELCGALKNIVAVGAGFCDGLRCGDNTKAAVIRLGLMEMIA 192
Cdd:PTZ00345 168 REEFSEATIGCEDKDDALIWQRLFDRPYFKINCVPDVIGVEVCGALKNIIALAAGFCDGLGLGTNTKSAIIRIGLEEMKL 247

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578805879 193 FARIFCKgQVSTATFLESCGVADLITTCYGGRNRRVAEAFARTG--KTIEELEKEMLNGQKLQGPQTSAEVYRILKQKGL 270
Cdd:PTZ00345 248 FGKIFFP-NVMDETFFESCGLADLITTCLGGRNVRCAAEFAKRNgkKSWEEIEAELLNGQKLQGTVTLKEVYEVLESHDL 326

                        330       340
                 ....*....|....*....|....*..
gi 578805879 271 LDKFPLFTAVYQICYESRPVQEMLSCL 297
Cdd:PTZ00345 327 KKEFPLFTVTYKIAFEGADPSSLIDVL 353
GpsA COG0240
Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Glycerol-3-phosphate ...
 7-301 8.93e-69

Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Glycerol-3-phosphate dehydrogenase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 440010 [Multi-domain]  Cd Length: 327  Bit Score: 216.83  E-value: 8.93e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578805879   7 KVCIVGSGNWGSAVAKIIGNNvkklqkfASTVKMWVFEETVngrklTDIINNDHENVKYLPGHKLPENV----------- 75
Cdd:COG0240    2 KIAVLGAGSWGTALAKVLARN-------GHEVTLWGRDPEV-----AEEINETRENPRYLPGVKLPENLratsdleeala 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578805879  76 ------------------------------------GIDegPEGLKLISDIIREKMGID--ISVLMGANIANEVAAEKFC 117
Cdd:COG0240   70 gadlvllavpsqalrevleqlapllppgapvvsatkGIE--PGTGLLMSEVIAEELPGAlrIAVLSGPSFAEEVARGLPT 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578805879 118 ETTIGSKVMENGLLFKELLQTPNFRITVVDDADTVELCGALKNIVAVGAGFCDGLRCGDNTKAAVIRLGLMEMIAFARIF 197
Cdd:COG0240  148 AVVVASEDEEVAERLQELLSTPYFRVYTSDDVIGVELGGALKNVIAIAAGIADGLGLGDNARAALITRGLAEMTRLGVAL 227

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578805879 198 ckgQVSTATFLESCGVADLITTCYG--GRNRRVAEAFARtGKTIEELEKEMlnGQKLQGPQTSAEVYRILKQKGLldKFP 275
Cdd:COG0240  228 ---GARPETFMGLAGLGDLVLTCTSdlSRNRRFGLALGK-GKSLEEALAEM--GMVAEGVYTAKAVYELAEKLGV--EMP 299

                        330       340
                 ....*....|....*....|....*.
gi 578805879 276 LFTAVYQICYESRPVQEMLSCLQSHP 301
Cdd:COG0240  300 ITEAVYAVLYEGKSPREAVEALMARP 325
NAD_Gly3P_dh_C pfam07479
NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; NAD-dependent ...
 148-294 3.26e-63

NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; NAD-dependent glycerol-3-phosphate dehydrogenase (GPDH) catalyzes the interconversion of dihydroxyacetone phosphate and L-glycerol-3-phosphate. This family represents the C-terminal substrate-binding domain.


Pssm-ID: 462178 [Multi-domain]  Cd Length: 142  Bit Score: 196.07  E-value: 3.26e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578805879  148 DADTVELCGALKNIVAVGAGFCDGLRCGDNTKAAVIRLGLMEMIAFARIFCKgqvSTATFLESCGVADLITTCYGG--RN 225
Cdd:pfam07479   1 DVIGVELGGALKNVIAIAAGIADGLGLGDNAKAALITRGLAEMIRLGKALGA---KPETFFGLAGLGDLIVTCTSGlsRN 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 578805879  226 RRVAEAFARtGKTIEELEKEMlnGQKLQGPQTSAEVYRILKQKGLldKFPLFTAVYQICYESRPVQEML 294
Cdd:pfam07479  78 RRFGEALGK-GKSLEEAEKEL--GQVAEGVYTAKAVYELAKKLGV--EMPIFEAVYRILYEGKSPEEAL 141
 
Name Accession Description Interval E-value
glycerol3P_DH TIGR03376
glycerol-3-phosphate dehydrogenase (NAD(+)); Members of this protein family are the eukaryotic ...
 7-297 6.67e-151

glycerol-3-phosphate dehydrogenase (NAD(+)); Members of this protein family are the eukaryotic enzyme, glycerol-3-phosphate dehydrogenase (NAD(+)) (EC 1.1.1.8). Enzymatic activity for 1.1.1.8 is defined as sn-glycerol 3-phosphate + NAD(+) = glycerone phosphate + NADH. Note the very similar reactions of enzymes defined as EC 1.1.1.94 and 1.1.99.5, assigned to families of proteins in the bacteria.


Pssm-ID: 274551 [Multi-domain]  Cd Length: 342  Bit Score: 426.37  E-value: 6.67e-151
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578805879    7 KVCIVGSGNWGSAVAKIIGNNVKKL-QKFASTVKMWVFEETVNGRKLTDIINNDHENVKYLPGHKLPENV---------- 75
Cdd:TIGR03376   1 RVAVVGSGNWGTAIAKIVAENARALpELFEESVRMWVFEEEIEGRNLTEIINTTHENVKYLPGIKLPANLvavpdlveaa 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578805879   76 -------------------------------------GIDEGPEGLKLISDIIREKMGIDISVLMGANIANEVAAEKFCE 118
Cdd:TIGR03376  81 kgadilvfviphqflegickqlkghvkpnaraiscikGLEVSKDGVKLLSDIIEEELGIPCGVLSGANLANEVAKEKFSE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578805879  119 TTIGSKVMEN----GLLFKELLQTPNFRITVVDDADTVELCGALKNIVAVGAGFCDGLRCGDNTKAAVIRLGLMEMIAFA 194
Cdd:TIGR03376 161 TTVGYRDPADfdvdARVLKALFHRPYFRVNVVDDVAGVEIAGALKNVVAIAAGFVDGLGWGDNAKAAVMRRGLLEMIKFA 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578805879  195 RIFCKGQVSTATFlESCGVADLITTCYGGRNRRVAEAFARTGKTIEELEKEMLNGQKLQGPQTSAEVYRILKQKGLLDKF 274
Cdd:TIGR03376 241 RMFFPTGEVTFTF-ESCGVADLITTCLGGRNFKVGRAFAKTGKSLEELEKELLNGQSLQGVATAKEVHELLKNKNKDDEF 319

                         330       340
                  ....*....|....*....|...
gi 578805879  275 PLFTAVYQICYESRPVQEMLSCL 297
Cdd:TIGR03376 320 PLFEAVYQILYEGLPPKKLPECL 342
PTZ00345 PTZ00345
glycerol-3-phosphate dehydrogenase; Provisional
 3-297 8.00e-131

glycerol-3-phosphate dehydrogenase; Provisional


Pssm-ID: 240373 [Multi-domain]  Cd Length: 365  Bit Score: 376.28  E-value: 8.00e-131
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578805879   3 AAPLKVCIVGSGNWGSAVAKIIGNNVKKLQKFASTVKMWVFEETVNGRKLTDIINNDHENVKYLPGHKLPENV------- 75
Cdd:PTZ00345   9 CGPLKVSVIGSGNWGSAISKVVGENTQRNYIFHNEVRMWVLEEIVEGEKLSDIINTKHENVKYLPGIKLPDNIvavsdlk 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578805879  76 -------------------------------------------GIDEGPEgLKLISDIIREKMGIDISVLMGANIANEVA 112
Cdd:PTZ00345  89 eavedadllifviphqflesvlsqikennnlkkharaisltkgIIVENGK-PVLCSDVIEEELGIPCCALSGANVANDVA 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578805879 113 AEKFCETTIGSKVMENGLLFKELLQTPNFRITVVDDADTVELCGALKNIVAVGAGFCDGLRCGDNTKAAVIRLGLMEMIA 192
Cdd:PTZ00345 168 REEFSEATIGCEDKDDALIWQRLFDRPYFKINCVPDVIGVEVCGALKNIIALAAGFCDGLGLGTNTKSAIIRIGLEEMKL 247

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578805879 193 FARIFCKgQVSTATFLESCGVADLITTCYGGRNRRVAEAFARTG--KTIEELEKEMLNGQKLQGPQTSAEVYRILKQKGL 270
Cdd:PTZ00345 248 FGKIFFP-NVMDETFFESCGLADLITTCLGGRNVRCAAEFAKRNgkKSWEEIEAELLNGQKLQGTVTLKEVYEVLESHDL 326

                        330       340
                 ....*....|....*....|....*..
gi 578805879 271 LDKFPLFTAVYQICYESRPVQEMLSCL 297
Cdd:PTZ00345 327 KKEFPLFTVTYKIAFEGADPSSLIDVL 353
GpsA COG0240
Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Glycerol-3-phosphate ...
 7-301 8.93e-69

Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Glycerol-3-phosphate dehydrogenase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 440010 [Multi-domain]  Cd Length: 327  Bit Score: 216.83  E-value: 8.93e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578805879   7 KVCIVGSGNWGSAVAKIIGNNvkklqkfASTVKMWVFEETVngrklTDIINNDHENVKYLPGHKLPENV----------- 75
Cdd:COG0240    2 KIAVLGAGSWGTALAKVLARN-------GHEVTLWGRDPEV-----AEEINETRENPRYLPGVKLPENLratsdleeala 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578805879  76 ------------------------------------GIDegPEGLKLISDIIREKMGID--ISVLMGANIANEVAAEKFC 117
Cdd:COG0240   70 gadlvllavpsqalrevleqlapllppgapvvsatkGIE--PGTGLLMSEVIAEELPGAlrIAVLSGPSFAEEVARGLPT 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578805879 118 ETTIGSKVMENGLLFKELLQTPNFRITVVDDADTVELCGALKNIVAVGAGFCDGLRCGDNTKAAVIRLGLMEMIAFARIF 197
Cdd:COG0240  148 AVVVASEDEEVAERLQELLSTPYFRVYTSDDVIGVELGGALKNVIAIAAGIADGLGLGDNARAALITRGLAEMTRLGVAL 227

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578805879 198 ckgQVSTATFLESCGVADLITTCYG--GRNRRVAEAFARtGKTIEELEKEMlnGQKLQGPQTSAEVYRILKQKGLldKFP 275
Cdd:COG0240  228 ---GARPETFMGLAGLGDLVLTCTSdlSRNRRFGLALGK-GKSLEEALAEM--GMVAEGVYTAKAVYELAEKLGV--EMP 299

                        330       340
                 ....*....|....*....|....*.
gi 578805879 276 LFTAVYQICYESRPVQEMLSCLQSHP 301
Cdd:COG0240  300 ITEAVYAVLYEGKSPREAVEALMARP 325
NAD_Gly3P_dh_C pfam07479
NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; NAD-dependent ...
 148-294 3.26e-63

NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; NAD-dependent glycerol-3-phosphate dehydrogenase (GPDH) catalyzes the interconversion of dihydroxyacetone phosphate and L-glycerol-3-phosphate. This family represents the C-terminal substrate-binding domain.


Pssm-ID: 462178 [Multi-domain]  Cd Length: 142  Bit Score: 196.07  E-value: 3.26e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578805879  148 DADTVELCGALKNIVAVGAGFCDGLRCGDNTKAAVIRLGLMEMIAFARIFCKgqvSTATFLESCGVADLITTCYGG--RN 225
Cdd:pfam07479   1 DVIGVELGGALKNVIAIAAGIADGLGLGDNAKAALITRGLAEMIRLGKALGA---KPETFFGLAGLGDLIVTCTSGlsRN 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 578805879  226 RRVAEAFARtGKTIEELEKEMlnGQKLQGPQTSAEVYRILKQKGLldKFPLFTAVYQICYESRPVQEML 294
Cdd:pfam07479  78 RRFGEALGK-GKSLEEAEKEL--GQVAEGVYTAKAVYELAKKLGV--EMPIFEAVYRILYEGKSPEEAL 141
gpsA PRK00094
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase;
7-297 1.32e-60

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase;


Pssm-ID: 234629 [Multi-domain]  Cd Length: 325  Bit Score: 195.67  E-value: 1.32e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578805879   7 KVCIVGSGNWGSAVAKIIGNNVKKlqkfastVKMWVFEETVngrklTDIINNDHENVKYLPGHKLPENV----------- 75
Cdd:PRK00094   3 KIAVLGAGSWGTALAIVLARNGHD-------VTLWARDPEQ-----AAEINADRENPRYLPGIKLPDNLrattdlaeala 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578805879  76 ------------------------------------GIDEGPegLKLISDIIREKMG--IDISVLMGANIANEVAAEKFC 117
Cdd:PRK00094  71 dadlilvavpsqalrevlkqlkpllppdapivwatkGIEPGT--GKLLSEVLEEELPdlAPIAVLSGPSFAKEVARGLPT 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578805879 118 ETTIGSKVMENGLLFKELLQTPNFRITVVDDADTVELCGALKNIVAVGAGFCDGLRCGDNTKAAVIRLGLMEMIAFARIF 197
Cdd:PRK00094 149 AVVIASTDEELAERVQELFHSPYFRVYTNTDVIGVELGGALKNVIAIAAGIADGLGLGDNARAALITRGLAEITRLGVAL 228

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578805879 198 -CKgqvsTATFLESCGVADLITTCYG--GRNRRVAEAFARtGKTIEELEKEMlnGQKLQGPQTSAEVYRILKQKGLldKF 274
Cdd:PRK00094 229 gAN----PETFLGLAGLGDLVLTCTSplSRNRRFGLALGQ-GKSLEEALAEI--GMVAEGVRTAKAVYELAKKLGV--EM 299

                        330       340
                 ....*....|....*....|...
gi 578805879 275 PLFTAVYQICYESRPVQEMLSCL 297
Cdd:PRK00094 300 PITEAVYAVLYEGKDPREAVEDL 322
NAD_Gly3P_dh_N pfam01210
NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; NAD-dependent ...
 7-128 1.64e-32

NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; NAD-dependent glycerol-3-phosphate dehydrogenase (GPDH) catalyzes the interconversion of dihydroxyacetone phosphate and L-glycerol-3-phosphate. This family represents the N-terminal NAD-binding domain.


Pssm-ID: 395967 [Multi-domain]  Cd Length: 158  Bit Score: 117.68  E-value: 1.64e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578805879    7 KVCIVGSGNWGSAVAKIIGNNvkklqkfASTVKMWVFEEtvngrKLTDIINNDHENVKYLPGHKLPENV----------- 75
Cdd:pfam01210   1 KIAVLGAGSWGTALAKVLADN-------GHEVRLWGRDE-----ELIEEINTTHENVRYLPGIKLPENLkattdlaealk 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578805879   76 ------------------------------------GIDEGpeGLKLISDIIREKMGI--DISVLMGANIANEVAAEKFC 117
Cdd:pfam01210  69 gadiivivvpsqalrevlkqlkgllkpdailvslskGIEPG--TLKLLSEVIEEELGIqpPIAVLSGPSHAEEVAQGLPT 146

                         170
                  ....*....|.
gi 578805879  118 ETTIGSKVMEN 128
Cdd:pfam01210 147 ATVIASKDEEA 157
PRK12439 PRK12439
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional
 1-270 3.92e-30

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional


Pssm-ID: 171500 [Multi-domain]  Cd Length: 341  Bit Score: 116.42  E-value: 3.92e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578805879   1 MAAA--PLKVCIVGSGNWGSAVAKIIGNNVKKLQkfastvkmWV-FEETVNGrkltdiINNDHENVKYLP-GHKLPENV- 75
Cdd:PRK12439   1 MAAAkrEPKVVVLGGGSWGTTVASICARRGPTLQ--------WVrSAETADD------INDNHRNSRYLGnDVVLSDTLr 66

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578805879  76 ----------------------------------------------GIDEGPEglKLISDIIREKM-GIDISVLMGANIA 108
Cdd:PRK12439  67 attdfaeaancadvvvmgvpshgfrgvltelakelrpwvpvvslvkGLEQGTN--MRMSQIIEEVLpGHPAGILAGPNIA 144

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578805879 109 NEVAAEKFCETTIGSKVMENGLLFKELLQTPNFRITVVDDADTVELCGALKNIVAVGAGFCDGLRCGDNTKAAVIRLGLM 188
Cdd:PRK12439 145 REVAEGYAAAAVLAMPDQHLATRLSPLFRTRRFRVYTTDDVVGVEMAGALKNVFAIAVGMGYSLGIGENTRAMVIARALR 224

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578805879 189 EMiafARIFCKGQVSTATFLESCGVADLITTCYG--GRNRRVAEAFARtGKTIEELEKEMlnGQKLQGPQTSAEVYRILK 266
Cdd:PRK12439 225 EM---TKLGVAMGGNPETFAGLAGMGDLIVTCTSqrSRNRHVGEQLGA-GKPIDEIIASM--NQVAEGVKAASVVMEFAD 298


                 ....
gi 578805879 267 QKGL 270
Cdd:PRK12439 299 EYGL 302
PRK14618 PRK14618
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional
 8-302 3.77e-27

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional


Pssm-ID: 237770 [Multi-domain]  Cd Length: 328  Bit Score: 108.03  E-value: 3.77e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578805879   8 VCIVGSGNWGSAVAKIignnvkkLQKFASTVKMWVFEETVNGRkltdiINNDHENVKYLPGHKLPENV------------ 75
Cdd:PRK14618   7 VAVLGAGAWGTALAVL-------AASKGVPVRLWARRPEFAAA-----LAAERENREYLPGVALPAELyptadpeealag 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578805879  76 -------------------------------GIDEGPEGLKLISDIIREKMGIDISVLMGANIANEVAAEKFCETTIGSK 124
Cdd:PRK14618  75 adfavvavpskalretlaglpralgyvscakGLAPDGGRLSELARVLEFLTQARVAVLSGPNHAEEIARFLPAATVVASP 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578805879 125 VMENGLLFKELLQTPNFRITVVDDADTVELCGALKNIVAVGAGFCDGLRCGDNTKAAVIRLGLMEMIAFARIFCKGQvst 204
Cdd:PRK14618 155 EPGLARRVQAAFSGPSFRVYTSRDRVGVELGGALKNVIALAAGMVDGLKLGDNAKAALITRGLREMVRFGVALGAEE--- 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578805879 205 ATFLESCGVADLITTCYG--GRNRRVAEAFARtgktieelekemlnGQKLQGPQTSAEVYRILKQKGLLDKF-------- 274
Cdd:PRK14618 232 ATFYGLSGLGDLIATATSphSRNRAAGEAIVR--------------GVDREHLEAGGKVVEGLYTVKALDAWakahghdl 297

                        330       340
                 ....*....|....*....|....*....
gi 578805879 275 PLFTAVYQICY-ESRPVQEMLSCLQSHPE 302
Cdd:PRK14618 298 PIVEAVARVARgGWDPLAGLRSLMGREAK 326
PRK14619 PRK14619
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional
 5-297 1.31e-21

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional


Pssm-ID: 237771 [Multi-domain]  Cd Length: 308  Bit Score: 92.36  E-value: 1.31e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578805879   5 PLKVCIVGSGNWGSAVAKIIGNNvkklqkfASTVKMW------VFEETVNGrklTDII---------NNDHENVKYLPgh 69
Cdd:PRK14619   4 PKTIAILGAGAWGSTLAGLASAN-------GHRVRVWsrrsglSLAAVLAD---ADVIvsavsmkgvRPVAEQVQALN-- 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578805879  70 kLPENV-------GIDegPEGLKLISDIIREKMGI-DISVLMGANIANEVAAEKFCETTIGSKVMENGLLFKELLQTPNF 141
Cdd:PRK14619  72 -LPPETiivtatkGLD--PETTRTPSQIWQAAFPNhPVVVLSGPNLSKEIQQGLPAATVVASRDLAAAETVQQIFSSERF 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578805879 142 RITVVDDADTVELCGALKNIVAVGAGFCDGLRCGDNTKAAVIRLGLMEMIafaRIFCKGQVSTATFLESCGVADLITTCY 221
Cdd:PRK14619 149 RVYTNSDPLGTELGGTLKNVIAIAAGVCDGLQLGTNAKAALVTRALPEMI---RVGTHLGAQTETFYGLSGLGDLLATCT 225

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 578805879 222 G--GRNRRVAEAFARtGKTIEE-LEKemLNGQKlQGPQTSAEVYRILKQKGLldKFPLFTAVYQICYESRPVQEMLSCL 297
Cdd:PRK14619 226 SplSRNYQVGYGLAQ-GKSLEQiLAE--LEGTA-EGVNTANVLVQLAQQQNI--AVPITEQVYRLLQGEITPQQALEEL 298
PRK14620 PRK14620
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional
 6-299 4.88e-20

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional


Pssm-ID: 173083 [Multi-domain]  Cd Length: 326  Bit Score: 88.35  E-value: 4.88e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578805879   6 LKVCIVGSGNWGSAVAKIIGNNvkklqkfASTVKMWvfeetvnGRKLTDI--INNDHENVKYLPGHKLPENV----GIDE 79
Cdd:PRK14620   1 MKISILGAGSFGTAIAIALSSK-------KISVNLW-------GRNHTTFesINTKRKNLKYLPTCHLPDNIsvksAIDE 66

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578805879  80 -----------------------------------------GPE--GLKLISDIIREKMGID-ISVLMGANIANEVAAEK 115
Cdd:PRK14620  67 vlsdnatciilavptqqlrticqqlqdchlkkntpilicskGIEksSLKFPSEIVNEILPNNpIAILSGPSFAKEIAEKL 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578805879 116 FCETTIGSKVMENGLLFKELLQTPNFRITVVDDADTVELCGALKNIVAVGAGFCDGLRCGDNTKAAVIRLGlMEMIAFAR 195
Cdd:PRK14620 147 PCSIVLAGQNETLGSSLISKLSNENLKIIYSQDIIGVQIGAALKNIIAIACGIVLGKNLGNNAHAAVITKG-MNEIKTLY 225

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578805879 196 IFCKGQVSTATFLESCGVADLITTCYGGRNRRVAEAFA-RTGKTIEELEKEmlNGQKLQGPQTSAEVYRILKQkgLLDKF 274
Cdd:PRK14620 226 SAKNGSIDLNTLIGPSCLGDLILTCTTLHSRNMSFGFKiGNGFNINQILSE--GKSVIEGFSTVKPLISLAKK--LNIEL 301

                        330       340
                 ....*....|....*....|....*
gi 578805879 275 PLFTAVYQICYESRPVQEMLSCLQS 299
Cdd:PRK14620 302 PICESIYNLLYENISLEKTISVILS 326
GPD_NAD_C_bact pfam20618
Bacterial GPD, NAD-dependent C-terminal; This is the C-terminal domain of NAD-dependent ...
 211-280 6.38e-07

Bacterial GPD, NAD-dependent C-terminal; This is the C-terminal domain of NAD-dependent glycerol-3-phosphate dehydrogenase (GPD) from bacteria and archaea. GPD catalyzes the reversible reduction of dihydroxyacetone phosphate to glycerol-3-phosphate.


Pssm-ID: 466767 [Multi-domain]  Cd Length: 66  Bit Score: 45.95  E-value: 6.38e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 578805879  211 CGVADLITTCYGG--RNRRVAEAFARtGKTIEELEKEMLngqkLQGPQTSAEVYRILKQKGLLDkFPLFTAV 280
Cdd:pfam20618   1 AGLGDLVLTCTSDlsRNRTFGLLLGK-GMTLAEAGNGQV----AEGVRTAKAVAAILARAHNVE-MPILEAV 66
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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