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Conserved domains on  [gi|578825190|ref|XP_006719980|]
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cilium assembly protein DZIP1 isoform X3 [Homo sapiens]

Protein Classification

ATP-binding protein; MDR family MFS transporter( domain architecture ID 13845362)

ATP-binding protein containing an AAA (ATPases Associated with various cellular Activities) domain, may function as the toxin for a type IV toxin-antitoxin resistance system| MDR (multi-drug resistance) family major facilitator superfamily (MFS) transporter confers resistance to specific drugs/toxins through their active efflux from the cell

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Dzip-like_N pfam13815
Iguana/Dzip1-like DAZ-interacting protein N-terminal; The DAZ gene-product - Deleted in ...
104-224 5.36e-47

Iguana/Dzip1-like DAZ-interacting protein N-terminal; The DAZ gene-product - Deleted in Azoospermia - and a closely related sequence are required early in germ-cell development in order to maintain germ-cell populations. This family is the N-terminal region that is the only part of the protein in some fungi and lower metazoa.


:

Pssm-ID: 433498 [Multi-domain]  Cd Length: 118  Bit Score: 163.26  E-value: 5.36e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825190  104 FQFRPRLESVDWRRLSAIDVDKVAGAVDVLTLQENIMNITFCKLEDEKCPHcqsGVDPVLLKLIRLAQFTIEYLLHSQEF 183
Cdd:pfam13815   1 FQFRPRSERLDWRKLASVDVDRVARDTDVDTLQRNIENITFCNLTREEAPH---FVDPHFLKLFRLAQLTIEYLLHSQEC 77
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 578825190  184 LTSQLHTLEERLRLSHCDGEQSKKLLTKQAGEIKTLKEECK 224
Cdd:pfam13815  78 LATILVKLEERLQEAQQRAEELEKELGRLEEELKKLKKESR 118
PRK03918 super family cl35229
DNA double-strand break repair ATPase Rad50;
190-486 1.32e-04

DNA double-strand break repair ATPase Rad50;


The actual alignment was detected with superfamily member PRK03918:

Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 45.83  E-value: 1.32e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825190 190 TLEERLRLSHCDGEQSKK---LLTKQAGEIKTLKEECKRRKKMISTQQLMIEAKANyyqchfCDKAFMNQAFLQSHIQRR 266
Cdd:PRK03918 256 KLEEKIRELEERIEELKKeieELEEKVKELKELKEKAEEYIKLSEFYEEYLDELRE------IEKRLSRLEEEINGIEER 329
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825190 267 HTEENShfeyqKNAQIEKLRSEIVVLKEELqltrSELEAAHhasavrfsKEYEMQKTKEEDFLKLFDRWKEEEKEKLV-- 344
Cdd:PRK03918 330 IKELEE-----KEERLEELKKKLKELEKRL----EELEERH--------ELYEEAKAKKEELERLKKRLTGLTPEKLEke 392
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825190 345 -DEMEKVKEMFMKEFKELTSKNSALEYQLSEIQKSNMQIKSNIGT------LKDAHEFKEDRSPYPQDFHNV---MQLLD 414
Cdd:PRK03918 393 lEELEKAKEEIEEEISKITARIGELKKEIKELKKAIEELKKAKGKcpvcgrELTEEHRKELLEEYTAELKRIekeLKEIE 472
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 578825190 415 SQESKWTARVQAIHQEHKKEkgRLLSHIEKLRTSMIDDLNASNVFYKKRIEELGQRLQEQNELIITQRQQIK 486
Cdd:PRK03918 473 EKERKLRKELRELEKVLKKE--SELIKLKELAEQLKELEEKLKKYNLEELEKKAEEYEKLKEKLIKLKGEIK 542
 
Name Accession Description Interval E-value
Dzip-like_N pfam13815
Iguana/Dzip1-like DAZ-interacting protein N-terminal; The DAZ gene-product - Deleted in ...
104-224 5.36e-47

Iguana/Dzip1-like DAZ-interacting protein N-terminal; The DAZ gene-product - Deleted in Azoospermia - and a closely related sequence are required early in germ-cell development in order to maintain germ-cell populations. This family is the N-terminal region that is the only part of the protein in some fungi and lower metazoa.


Pssm-ID: 433498 [Multi-domain]  Cd Length: 118  Bit Score: 163.26  E-value: 5.36e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825190  104 FQFRPRLESVDWRRLSAIDVDKVAGAVDVLTLQENIMNITFCKLEDEKCPHcqsGVDPVLLKLIRLAQFTIEYLLHSQEF 183
Cdd:pfam13815   1 FQFRPRSERLDWRKLASVDVDRVARDTDVDTLQRNIENITFCNLTREEAPH---FVDPHFLKLFRLAQLTIEYLLHSQEC 77
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 578825190  184 LTSQLHTLEERLRLSHCDGEQSKKLLTKQAGEIKTLKEECK 224
Cdd:pfam13815  78 LATILVKLEERLQEAQQRAEELEKELGRLEEELKKLKKESR 118
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
190-486 1.32e-04

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 45.83  E-value: 1.32e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825190 190 TLEERLRLSHCDGEQSKK---LLTKQAGEIKTLKEECKRRKKMISTQQLMIEAKANyyqchfCDKAFMNQAFLQSHIQRR 266
Cdd:PRK03918 256 KLEEKIRELEERIEELKKeieELEEKVKELKELKEKAEEYIKLSEFYEEYLDELRE------IEKRLSRLEEEINGIEER 329
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825190 267 HTEENShfeyqKNAQIEKLRSEIVVLKEELqltrSELEAAHhasavrfsKEYEMQKTKEEDFLKLFDRWKEEEKEKLV-- 344
Cdd:PRK03918 330 IKELEE-----KEERLEELKKKLKELEKRL----EELEERH--------ELYEEAKAKKEELERLKKRLTGLTPEKLEke 392
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825190 345 -DEMEKVKEMFMKEFKELTSKNSALEYQLSEIQKSNMQIKSNIGT------LKDAHEFKEDRSPYPQDFHNV---MQLLD 414
Cdd:PRK03918 393 lEELEKAKEEIEEEISKITARIGELKKEIKELKKAIEELKKAKGKcpvcgrELTEEHRKELLEEYTAELKRIekeLKEIE 472
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 578825190 415 SQESKWTARVQAIHQEHKKEkgRLLSHIEKLRTSMIDDLNASNVFYKKRIEELGQRLQEQNELIITQRQQIK 486
Cdd:PRK03918 473 EKERKLRKELRELEKVLKKE--SELIKLKELAEQLKELEEKLKKYNLEELEKKAEEYEKLKEKLIKLKGEIK 542
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
270-489 1.18e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 42.74  E-value: 1.18e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825190   270 ENSHFEYQKNaqIEKLRSEIVVLKEELQLTRSELEAAHHAsavrfskeyemQKTKEEDFLKLfdRWKEEEKEKLVDEMEK 349
Cdd:TIGR02168  669 NSSILERRRE--IEELEEKIEELEEKIAELEKALAELRKE-----------LEELEEELEQL--RKELEELSRQISALRK 733
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825190   350 VKEMFMKEFKELTSKNSALEYQLSEIQKSNMQIKSNIGTLKDA-HEFKEDRSPYPQDFHNVMQLLDSQESKWTArVQAIH 428
Cdd:TIGR02168  734 DLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEElAEAEAEIEELEAQIEQLKEELKALREALDE-LRAEL 812
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 578825190   429 QEHKKEKGRLLSHIEKLRTSMIDdlnasnvfYKKRIEELGQRLQEQNELIITQRQQIKDFT 489
Cdd:TIGR02168  813 TLLNEEAANLRERLESLERRIAA--------TERRLEDLEEQIEELSEDIESLAAEIEELE 865
COG5022 COG5022
Myosin heavy chain [General function prediction only];
224-477 4.61e-03

Myosin heavy chain [General function prediction only];


Pssm-ID: 227355 [Multi-domain]  Cd Length: 1463  Bit Score: 40.83  E-value: 4.61e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825190  224 KRRKKMISTQQLMieaKANYYQCHFCDKAFMNQAFlqsHIQRRHTEENSHFEY-QKNAQIEKLRSEIV---VLKEELQLT 299
Cdd:COG5022   766 QALKRIKKIQVIQ---HGFRLRRLVDYELKWRLFI---KLQPLLSLLGSRKEYrSYLACIIKLQKTIKrekKLRETEEVE 839
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825190  300 RSELEAAHHASAVRFSKEYEMQKTKEEDFLKLFDRWKEEEKEK-LVDEMEKVKEmfmkeFKELTSKNSALEYQLSEI--- 375
Cdd:COG5022   840 FSLKAEVLIQKFGRSLKAKKRFSLLKKETIYLQSAQRVELAERqLQELKIDVKS-----ISSLKLVNLELESEIIELkks 914
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825190  376 QKSNMQIKSnigtlkdahEFKEDRSPYPQDFHNVMQLLDSQEskwtarvqaIHQEHKKEKGRLLSHIEKLRTS------M 449
Cdd:COG5022   915 LSSDLIENL---------EFKTELIARLKKLLNNIDLEEGPS---------IEYVKLPELNKLHEVESKLKETseeyedL 976
                         250       260
                  ....*....|....*....|....*...
gi 578825190  450 IDDLNASNVFYKKRIEELGQRLQEQNEL 477
Cdd:COG5022   977 LKKSTILVREGNKANSELKNFKKELAEL 1004
 
Name Accession Description Interval E-value
Dzip-like_N pfam13815
Iguana/Dzip1-like DAZ-interacting protein N-terminal; The DAZ gene-product - Deleted in ...
104-224 5.36e-47

Iguana/Dzip1-like DAZ-interacting protein N-terminal; The DAZ gene-product - Deleted in Azoospermia - and a closely related sequence are required early in germ-cell development in order to maintain germ-cell populations. This family is the N-terminal region that is the only part of the protein in some fungi and lower metazoa.


Pssm-ID: 433498 [Multi-domain]  Cd Length: 118  Bit Score: 163.26  E-value: 5.36e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825190  104 FQFRPRLESVDWRRLSAIDVDKVAGAVDVLTLQENIMNITFCKLEDEKCPHcqsGVDPVLLKLIRLAQFTIEYLLHSQEF 183
Cdd:pfam13815   1 FQFRPRSERLDWRKLASVDVDRVARDTDVDTLQRNIENITFCNLTREEAPH---FVDPHFLKLFRLAQLTIEYLLHSQEC 77
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 578825190  184 LTSQLHTLEERLRLSHCDGEQSKKLLTKQAGEIKTLKEECK 224
Cdd:pfam13815  78 LATILVKLEERLQEAQQRAEELEKELGRLEEELKKLKKESR 118
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
190-486 1.32e-04

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 45.83  E-value: 1.32e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825190 190 TLEERLRLSHCDGEQSKK---LLTKQAGEIKTLKEECKRRKKMISTQQLMIEAKANyyqchfCDKAFMNQAFLQSHIQRR 266
Cdd:PRK03918 256 KLEEKIRELEERIEELKKeieELEEKVKELKELKEKAEEYIKLSEFYEEYLDELRE------IEKRLSRLEEEINGIEER 329
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825190 267 HTEENShfeyqKNAQIEKLRSEIVVLKEELqltrSELEAAHhasavrfsKEYEMQKTKEEDFLKLFDRWKEEEKEKLV-- 344
Cdd:PRK03918 330 IKELEE-----KEERLEELKKKLKELEKRL----EELEERH--------ELYEEAKAKKEELERLKKRLTGLTPEKLEke 392
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825190 345 -DEMEKVKEMFMKEFKELTSKNSALEYQLSEIQKSNMQIKSNIGT------LKDAHEFKEDRSPYPQDFHNV---MQLLD 414
Cdd:PRK03918 393 lEELEKAKEEIEEEISKITARIGELKKEIKELKKAIEELKKAKGKcpvcgrELTEEHRKELLEEYTAELKRIekeLKEIE 472
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 578825190 415 SQESKWTARVQAIHQEHKKEkgRLLSHIEKLRTSMIDDLNASNVFYKKRIEELGQRLQEQNELIITQRQQIK 486
Cdd:PRK03918 473 EKERKLRKELRELEKVLKKE--SELIKLKELAEQLKELEEKLKKYNLEELEKKAEEYEKLKEKLIKLKGEIK 542
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
270-489 1.18e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 42.74  E-value: 1.18e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825190   270 ENSHFEYQKNaqIEKLRSEIVVLKEELQLTRSELEAAHHAsavrfskeyemQKTKEEDFLKLfdRWKEEEKEKLVDEMEK 349
Cdd:TIGR02168  669 NSSILERRRE--IEELEEKIEELEEKIAELEKALAELRKE-----------LEELEEELEQL--RKELEELSRQISALRK 733
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825190   350 VKEMFMKEFKELTSKNSALEYQLSEIQKSNMQIKSNIGTLKDA-HEFKEDRSPYPQDFHNVMQLLDSQESKWTArVQAIH 428
Cdd:TIGR02168  734 DLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEElAEAEAEIEELEAQIEQLKEELKALREALDE-LRAEL 812
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 578825190   429 QEHKKEKGRLLSHIEKLRTSMIDdlnasnvfYKKRIEELGQRLQEQNELIITQRQQIKDFT 489
Cdd:TIGR02168  813 TLLNEEAANLRERLESLERRIAA--------TERRLEDLEEQIEELSEDIESLAAEIEELE 865
COG5022 COG5022
Myosin heavy chain [General function prediction only];
224-477 4.61e-03

Myosin heavy chain [General function prediction only];


Pssm-ID: 227355 [Multi-domain]  Cd Length: 1463  Bit Score: 40.83  E-value: 4.61e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825190  224 KRRKKMISTQQLMieaKANYYQCHFCDKAFMNQAFlqsHIQRRHTEENSHFEY-QKNAQIEKLRSEIV---VLKEELQLT 299
Cdd:COG5022   766 QALKRIKKIQVIQ---HGFRLRRLVDYELKWRLFI---KLQPLLSLLGSRKEYrSYLACIIKLQKTIKrekKLRETEEVE 839
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825190  300 RSELEAAHHASAVRFSKEYEMQKTKEEDFLKLFDRWKEEEKEK-LVDEMEKVKEmfmkeFKELTSKNSALEYQLSEI--- 375
Cdd:COG5022   840 FSLKAEVLIQKFGRSLKAKKRFSLLKKETIYLQSAQRVELAERqLQELKIDVKS-----ISSLKLVNLELESEIIELkks 914
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825190  376 QKSNMQIKSnigtlkdahEFKEDRSPYPQDFHNVMQLLDSQEskwtarvqaIHQEHKKEKGRLLSHIEKLRTS------M 449
Cdd:COG5022   915 LSSDLIENL---------EFKTELIARLKKLLNNIDLEEGPS---------IEYVKLPELNKLHEVESKLKETseeyedL 976
                         250       260
                  ....*....|....*....|....*...
gi 578825190  450 IDDLNASNVFYKKRIEELGQRLQEQNEL 477
Cdd:COG5022   977 LKKSTILVREGNKANSELKNFKKELAEL 1004
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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