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Conserved domains on  [gi|578825921|ref|XP_006720248|]
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F-box only protein 34 isoform X2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
F-box_FBXO34 cd22176
F-box domain found in F-box only protein 34 (FBXO34) and similar proteins; FBXO34, also called ...
 575-622 1.04e-28

F-box domain found in F-box only protein 34 (FBXO34) and similar proteins; FBXO34, also called FBX34, likely functions as the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


:

Pssm-ID: 438947  Cd Length: 48  Bit Score: 108.39  E-value: 1.04e-28
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 578825921 575 MAFLPHHIMVKIFRLLPTKSLVALKCTCCYFKFIIEYYNIRPADSRWV 622
Cdd:cd22176    1 MAFLPHHILVKIFRFLPTRTLAALKCTCHYFKFIIENYDIRPADSRWV 48
 
Name Accession Description Interval E-value
F-box_FBXO34 cd22176
F-box domain found in F-box only protein 34 (FBXO34) and similar proteins; FBXO34, also called ...
 575-622 1.04e-28

F-box domain found in F-box only protein 34 (FBXO34) and similar proteins; FBXO34, also called FBX34, likely functions as the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438947  Cd Length: 48  Bit Score: 108.39  E-value: 1.04e-28
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 578825921 575 MAFLPHHIMVKIFRLLPTKSLVALKCTCCYFKFIIEYYNIRPADSRWV 622
Cdd:cd22176    1 MAFLPHHILVKIFRFLPTRTLAALKCTCHYFKFIIENYDIRPADSRWV 48
F-box-like pfam12937
F-box-like; This is an F-box-like family.
 575-609 2.53e-04

F-box-like; This is an F-box-like family.


Pssm-ID: 463757 [Multi-domain]  Cd Length: 45  Bit Score: 39.00  E-value: 2.53e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 578825921  575 MAFLPHHIMVKIFRLLPTKSLVALKCTCCYFKFII 609
Cdd:pfam12937   1 LSSLPDEILLQIFSYLDPKDLLRLALVCRRWRELA 35
FBOX smart00256
A Receptor for Ubiquitination Targets;
578-611 1.11e-03

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 37.03  E-value: 1.11e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 578825921   578 LPHHIMVKIFRLLPTKSLVALKCTCCYFKFIIEY 611
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLIDS 34
 
Name Accession Description Interval E-value
F-box_FBXO34 cd22176
F-box domain found in F-box only protein 34 (FBXO34) and similar proteins; FBXO34, also called ...
 575-622 1.04e-28

F-box domain found in F-box only protein 34 (FBXO34) and similar proteins; FBXO34, also called FBX34, likely functions as the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438947  Cd Length: 48  Bit Score: 108.39  E-value: 1.04e-28
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 578825921 575 MAFLPHHIMVKIFRLLPTKSLVALKCTCCYFKFIIEYYNIRPADSRWV 622
Cdd:cd22176    1 MAFLPHHILVKIFRFLPTRTLAALKCTCHYFKFIIENYDIRPADSRWV 48
F-box_FBXO34-like cd22105
F-box domain found in F-box only protein 34 (FBXO34), F-box only protein 46 (FBXO46) and ...
 575-621 8.12e-25

F-box domain found in F-box only protein 34 (FBXO34), F-box only protein 46 (FBXO46) and similar proteins; This family includes FBXO34 (also called FBX34) and FBXO46 (also called FBX46), both of which are substrate-recognition components of SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. The SCF(FBOX46) complex mediates degradation of the tumor suppressor FBXO31 and thereby prevents premature cellular senescence. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438877  Cd Length: 47  Bit Score: 97.47  E-value: 8.12e-25
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 578825921 575 MAFLPHHIMVKIFRLLPTKSLVALKCTCCYFKFIIEYYNIRPADSRW 621
Cdd:cd22105    1 FLLLPDHVLSKIFSHLPTRSLAALKCTCKDFKWLIEMFDVRGSDSRW 47
F-box_FBXO46 cd22177
F-box domain found in F-box only protein 46 (FBXO46) and similar proteins; FBXO46, also called ...
 575-621 1.64e-17

F-box domain found in F-box only protein 46 (FBXO46) and similar proteins; FBXO46, also called FBX46, or F-box only protein 34-like, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex that mediates degradation of the tumor suppressor FBXO31 and thereby prevents premature cellular senescence. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438948  Cd Length: 47  Bit Score: 76.49  E-value: 1.64e-17
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 578825921 575 MAFLPHHIMVKIFRLLPTKSLVALKCTCCYFKFIIEYYNIRPADSRW 621
Cdd:cd22177    1 MLLLPDHILVNIFSYLPTRSLAALKCSCHHFKDIIETYGVRATDSRW 47
F-box_SF cd09917
F-box domain superfamily; This short domain is commonly found at the N-terminus of various ...
 578-610 2.23e-04

F-box domain superfamily; This short domain is commonly found at the N-terminus of various proteins, and typically co-occurs with one or more other conserved domains or motifs, such as leucine rich repeats, WD40 repeats, kelch, tub, spry, and others. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. One of the best researched roles of F-box proteins is their participation in SCF (Skp1-Cul1-F-box protein), a multi-protein complex that functions as a ubiquitin E3 ligase, where the role of the F-box protein is to recruit target substrates. Gene families containing the F-box are found greatly expanded in narrow taxonomic lineages, such as flowering plants and nematodes. In this hierarchical classification, many of the subfamilies are named according to their domain architectures.


Pssm-ID: 438852  Cd Length: 35  Bit Score: 38.96  E-value: 2.23e-04
                         10        20        30
                 ....*....|....*....|....*....|...
gi 578825921 578 LPHHIMVKIFRLLPTKSLVALKCTCCYFKFIIE 610
Cdd:cd09917    3 LPDEILLKILSYLDPRDLLRLSLVCKRWRELAS 35
F-box-like pfam12937
F-box-like; This is an F-box-like family.
 575-609 2.53e-04

F-box-like; This is an F-box-like family.


Pssm-ID: 463757 [Multi-domain]  Cd Length: 45  Bit Score: 39.00  E-value: 2.53e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 578825921  575 MAFLPHHIMVKIFRLLPTKSLVALKCTCCYFKFII 609
Cdd:pfam12937   1 LSSLPDEILLQIFSYLDPKDLLRLALVCRRWRELA 35
FBOX smart00256
A Receptor for Ubiquitination Targets;
578-611 1.11e-03

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 37.03  E-value: 1.11e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 578825921   578 LPHHIMVKIFRLLPTKSLVALKCTCCYFKFIIEY 611
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLIDS 34
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
 578-609 1.43e-03

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 36.75  E-value: 1.43e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 578825921  578 LPHHIMVKIFRLLPTKSLVALKCTCCYFKFII 609
Cdd:pfam00646   4 LPDDLLLEILSRLDPKDLLRLSLVSKRWRSLV 35
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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