NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|578830804|ref|XP_006721915|]
View 

cerebellar degeneration-related protein 2-like isoform X1 [Homo sapiens]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
SMC_prok_B super family cl37069
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 23-225 6.42e-08

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


The actual alignment was detected with superfamily member TIGR02168:

Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 55.06  E-value: 6.42e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578830804    23 DLEQDLHLAAELGKTLLERNKELEGSLQQMYSTNEEQVQEIEYLTKQLDTLRHVNEQHAKVYEQLDLTARDLELTNHRLV 102
Cdd:TIGR02168  681 ELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELE 760

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578830804   103 LESKAAQQKIHGLTETIERLQAQVEELQAQVEQLRGL-----EQLRVLR-EKRERRRTIHTFPCLKELCTSPRSSLELGP 176
Cdd:TIGR02168  761 AEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEElkalrEALDELRaELTLLNEEAANLRERLESLERRIAATERRL 840

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*....
gi 578830804   177 RPLEQENERLQTLVGALRSQVSQERQRKERAEREYTAVLQEYSELERQL 225
Cdd:TIGR02168  841 EDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNERASLEEAL 889
 
Name Accession Description Interval E-value
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 23-225 6.42e-08

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 55.06  E-value: 6.42e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578830804    23 DLEQDLHLAAELGKTLLERNKELEGSLQQMYSTNEEQVQEIEYLTKQLDTLRHVNEQHAKVYEQLDLTARDLELTNHRLV 102
Cdd:TIGR02168  681 ELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELE 760

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578830804   103 LESKAAQQKIHGLTETIERLQAQVEELQAQVEQLRGL-----EQLRVLR-EKRERRRTIHTFPCLKELCTSPRSSLELGP 176
Cdd:TIGR02168  761 AEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEElkalrEALDELRaELTLLNEEAANLRERLESLERRIAATERRL 840

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*....
gi 578830804   177 RPLEQENERLQTLVGALRSQVSQERQRKERAEREYTAVLQEYSELERQL 225
Cdd:TIGR02168  841 EDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNERASLEEAL 889
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
61-230 1.13e-07

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 54.54  E-value: 1.13e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578830804   61 QEIEYLTKQLDTLRHVNEQHAKvYEQLDLTARDLELTNHRLVL-----ESKAAQQKIHGLTETIERLQAQVEELQAQVEQ 135
Cdd:COG4913   242 EALEDAREQIELLEPIRELAER-YAAARERLAELEYLRAALRLwfaqrRLELLEAELEELRAELARLEAELERLEARLDA 320

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578830804  136 LRG-----------------------LEQLRVLREKRERRRTIhtfpcLKELCTSPRSSLELGPRPLEQENERLQTLVGA 192
Cdd:COG4913   321 LREeldeleaqirgnggdrleqlereIERLERELEERERRRAR-----LEALLAALGLPLPASAEEFAALRAEAAALLEA 395

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 578830804  193 LRSQVSQERQRKERAEREYTAVLQEYSELERQLCEMEA 230
Cdd:COG4913   396 LEEELEALEEALAEAEAALRDLRRELRELEAEIASLER 433
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 12-225 6.76e-04

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 42.02  E-value: 6.76e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578830804   12 AEEEESWYDQQDLEQdlhLAAELGKT-------LLERNKE---LEGSLQQMYSTNEEQVQEIEYLTKQLDTLRHVNEQHA 81
Cdd:pfam05483 415 AEDEKLLDEKKQFEK---IAEELKGKeqeliflLQAREKEihdLEIQLTAIKTSEEHYLKEVEDLKTELEKEKLKNIELT 491

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578830804   82 KVYEQLDLTARDLELTNHRLVLESKAAQQKIHGLTETIERLQAQVEELQAQVEQLRglEQLRVLREKRERRRTihTFPCL 161
Cdd:pfam05483 492 AHCDKLLLENKELTQEASDMTLELKKHQEDIINCKKQEERMLKQIENLEEKEMNLR--DELESVREEFIQKGD--EVKCK 567

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 578830804  162 KELCTSPRSSLELGPRPLEQENERLQTLVGALRSQVSQERQRKERAEREYTAVLQEYSELERQL 225
Cdd:pfam05483 568 LDKSEENARSIEYEVLKKEKQMKILENKCNNLKKQIENKNKNIEELHQENKALKKKGSAENKQL 631
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
2-229 1.62e-03

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 40.82  E-value: 1.62e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578830804   2 RRAAGMEDFsaeeEESWYDQQDLEQDLHLAAELGKTLLERNKELEGSLQQMYSTNEEQVQEIEYLTKQLDTLRHVNEQHA 81
Cdd:PRK03918 152 RQILGLDDY----ENAYKNLGEVIKEIKRRIERLEKFIKRTENIEELIKEKEKELEEVLREINEISSELPELREELEKLE 227

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578830804  82 KVYEQLDLTARDLELTNHRLVL---ESKAAQQKIHGLTETIERLQAQVEELQAQVEQLRGLEqlrvlrEKRERRRTIHTF 158
Cdd:PRK03918 228 KEVKELEELKEEIEELEKELESlegSKRKLEEKIRELEERIEELKKEIEELEEKVKELKELK------EKAEEYIKLSEF 301

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 578830804 159 pclkelctspRSSLELGPRPLEQENERLQTLVGALRSQVSQERQRKERAEReytaVLQEYSELERQLCEME 229
Cdd:PRK03918 302 ----------YEEYLDELREIEKRLSRLEEEINGIEERIKELEEKEERLEE----LKKKLKELEKRLEELE 358
 
Name Accession Description Interval E-value
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 23-225 6.42e-08

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 55.06  E-value: 6.42e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578830804    23 DLEQDLHLAAELGKTLLERNKELEGSLQQMYSTNEEQVQEIEYLTKQLDTLRHVNEQHAKVYEQLDLTARDLELTNHRLV 102
Cdd:TIGR02168  681 ELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELE 760

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578830804   103 LESKAAQQKIHGLTETIERLQAQVEELQAQVEQLRGL-----EQLRVLR-EKRERRRTIHTFPCLKELCTSPRSSLELGP 176
Cdd:TIGR02168  761 AEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEElkalrEALDELRaELTLLNEEAANLRERLESLERRIAATERRL 840

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*....
gi 578830804   177 RPLEQENERLQTLVGALRSQVSQERQRKERAEREYTAVLQEYSELERQL 225
Cdd:TIGR02168  841 EDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNERASLEEAL 889
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
61-230 1.13e-07

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 54.54  E-value: 1.13e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578830804   61 QEIEYLTKQLDTLRHVNEQHAKvYEQLDLTARDLELTNHRLVL-----ESKAAQQKIHGLTETIERLQAQVEELQAQVEQ 135
Cdd:COG4913   242 EALEDAREQIELLEPIRELAER-YAAARERLAELEYLRAALRLwfaqrRLELLEAELEELRAELARLEAELERLEARLDA 320

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578830804  136 LRG-----------------------LEQLRVLREKRERRRTIhtfpcLKELCTSPRSSLELGPRPLEQENERLQTLVGA 192
Cdd:COG4913   321 LREeldeleaqirgnggdrleqlereIERLERELEERERRRAR-----LEALLAALGLPLPASAEEFAALRAEAAALLEA 395

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 578830804  193 LRSQVSQERQRKERAEREYTAVLQEYSELERQLCEMEA 230
Cdd:COG4913   396 LEEELEALEEALAEAEAALRDLRRELRELEAEIASLER 433
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 35-230 3.84e-06

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 49.68  E-value: 3.84e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578830804    35 GKTLLERNKELEGSLQQMYSTNEEQVQEIEYLTKQLDTLRHVNEQHAKVYEQLDLTARDLELTnhrlvlESKAAQQKIHG 114
Cdd:TIGR02169  225 GYELLKEKEALERQKEAIERQLASLEEELEKLTEEISELEKRLEEIEQLLEELNKKIKDLGEE------EQLRVKEKIGE 298

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578830804   115 LTETIERLQAQVEELQAQVEQLRG------LEQLRVLREKRERRRTIHTFPCLKELCTSPRSSLELGPRPLEQENERLQT 188
Cdd:TIGR02169  299 LEAEIASLERSIAEKERELEDAEErlakleAEIDKLLAEIEELEREIEEERKRRDKLTEEYAELKEELEDLRAELEEVDK 378

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|..
gi 578830804   189 LVGALRSQVSQERQRKERAEREYTAVLQEYSELERQLCEMEA 230
Cdd:TIGR02169  379 EFAETRDELKDYREKLEKLKREINELKRELDRLQEELQRLSE 420
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 57-230 1.97e-05

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 47.24  E-value: 1.97e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578830804  57 EEQVQEIEYLTKQLDTLRHVNEQHAKVYEQLDLTARDLELTNHRLVLESKAAQQKIHGLTETIERLQAQVEELQAQVEQL 136
Cdd:COG1196  221 ELKELEAELLLLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARL 300

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578830804 137 RGLEQLRVLREKRERRRTIHtfpclkelctsprsslelgprpLEQENERLQTLVGALRSQVSQERQRKERAEREYTAVLQ 216
Cdd:COG1196  301 EQDIARLEERRRELEERLEE----------------------LEEELAELEEELEELEEELEELEEELEEAEEELEEAEA 358

                        170
                 ....*....|....
gi 578830804 217 EYSELERQLCEMEA 230
Cdd:COG1196  359 ELAEAEEALLEAEA 372
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 7-225 4.97e-05

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 45.83  E-value: 4.97e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578830804     7 MEDFSAEEEESWYDQQDLEQDLH-LAAELGKTLLERNKELEgslqqmysTNEEQVQEIEYLTKQLDTLRHVNEQHAKVYE 85
Cdd:TIGR02169  296 IGELEAEIASLERSIAEKERELEdAEERLAKLEAEIDKLLA--------EIEELEREIEEERKRRDKLTEEYAELKEELE 367

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578830804    86 QLDLTARDLELTNHRLVLESKAAQQKIHGLTETIERLQAQVEELQAQVEQLRglEQLRVLREKRERRRTIHTfpclkELc 165
Cdd:TIGR02169  368 DLRAELEEVDKEFAETRDELKDYREKLEKLKREINELKRELDRLQEELQRLS--EELADLNAAIAGIEAKIN-----EL- 439

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 578830804   166 TSPRSSLELGPRPLEQENERLQTLVGALRSQVSQERQRKERAEREYTAVLQEYSELERQL 225
Cdd:TIGR02169  440 EEEKEDKALEIKKQEWKLEQLAADLSKYEQELYDLKEEYDRVEKELSKLQRELAEAEAQA 499
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 38-225 5.32e-05

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 45.70  E-value: 5.32e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578830804  38 LLERNKELEGSLQQMYSTNEEQVQEIEYLTKQLDTLRHVNEQHAKVYEQLDLTARDLELTNHRLVLESKAAQQKIHGLTE 117
Cdd:COG1196  307 LEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAE 386

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578830804 118 TIERLQAQVEELQAQVEQLRGLEQLRVLREKRERRRtihtfpclkelctspRSSLELGPRPLEQENERLQTLVGALRSQV 197
Cdd:COG1196  387 ELLEALRAAAELAAQLEELEEAEEALLERLERLEEE---------------LEELEEALAELEEEEEEEEEALEEAAEEE 451

                        170       180
                 ....*....|....*....|....*...
gi 578830804 198 SQERQRKERAEREYTAVLQEYSELERQL 225
Cdd:COG1196  452 AELEEEEEALLELLAELLEEAALLEAAL 479
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 2-237 1.41e-04

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 44.66  E-value: 1.41e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578830804     2 RRAAGMEDFSAEEEESWYDQQDLEQDLHLAAELGKTLLERNKELEGSLQQMYSTNEEQVQEIEYLTKQLDTLRHVNEQHA 81
Cdd:TIGR02168  667 KTNSSILERRREIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLE 746

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578830804    82 KVYEQLDLTARDLELTNHRLVLESKAAQQKIHGLTETIERLQAQVEELQAQVEQLRglEQLRVLR-EKRERRRTIHTFPC 160
Cdd:TIGR02168  747 ERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALR--EALDELRaELTLLNEEAANLRE 824

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578830804   161 LKELCTSPRSSLELGPRPLEQENERLQTLVGALRSQVSQERQRKERAEREYTAVLQEYSELERQLCE------------- 227
Cdd:TIGR02168  825 RLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNERASLEEALALlrseleelseelr 904

                          250       260
                   ....*....|....*....|....*....
gi 578830804   228 -------------------MEACRLRVQE 237
Cdd:TIGR02168  905 eleskrselrreleelrekLAQLELRLEG 933
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 20-225 1.97e-04

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 43.77  E-value: 1.97e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578830804  20 DQQDLEQDLHLAAELGKTLLERNKELEGSLQQMYSTNEEQVQEIEYLTKQLDTLRHVNEQHAKVYEQLDLTARDLELTNH 99
Cdd:COG1196  240 ELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLE 319

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578830804 100 RLVLESKAAQQKIHGLTETIERLQAQVEELQAQVEQLRGLEQLRVLREKRERRRTIHTfpcLKELCTSPRSSLElgprpL 179
Cdd:COG1196  320 ELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEA---EEELEELAEELLE-----A 391

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 578830804 180 EQENERLQTLVGALRSQVSQERQRKERAEREYTAVLQEYSELERQL 225
Cdd:COG1196  392 LRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEE 437
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 5-270 4.32e-04

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 42.74  E-value: 4.32e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578830804     5 AGMEDFSAEEEESWYDQQDLEQDLHLAAELGKTLLERNKELEGSLQQMYSTNEEQVQEIEYLTKQL----DTLRHVNEQH 80
Cdd:TIGR02168  239 EELEELQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKqilrERLANLERQL 318

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578830804    81 AKVYEQLDLTARDLEltnhRLVLESKAAQQKIHGLTETIERLQAQVEELQAQVEQLRglEQLRVLREKRERRRTihTFPC 160
Cdd:TIGR02168  319 EELEAQLEELESKLD----ELAEELAELEEKLEELKEELESLEAELEELEAELEELE--SRLEELEEQLETLRS--KVAQ 390

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578830804   161 LKELCTSPRSSLELgprpLEQENERLQTLVGALRSQVSQERQRKERAEREytAVLQEYSELERQLCEMEACRLRVQELEA 240
Cdd:TIGR02168  391 LELQIASLNNEIER----LEARLERLEDRRERLQQEIEELLKKLEEAELK--ELQAELEELEEELEELQEELERLEEALE 464

                          250       260       270
                   ....*....|....*....|....*....|
gi 578830804   241 ELLELQQMKQAKTYLLGPDDHLAEALLAPL 270
Cdd:TIGR02168  465 ELREELEEAEQALDAAERELAQLQARLDSL 494
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 61-306 6.51e-04

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 41.67  E-value: 6.51e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578830804  61 QEIEYLTKQLDTLRhvnEQHAKVYEQLDLTARDLELTNHRLvlesKAAQQKIHGLTETIERLQAQVEELQAQVEQLRGL- 139
Cdd:COG4942   34 QEIAELEKELAALK---KEEKALLKQLAALERRIAALARRI----RALEQELAALEAELAELEKEIAELRAELEAQKEEl 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578830804 140 -EQLRVLrEKRERRRTIhtfpclkELCTSPRSSLELGPR--PLEQENERLQTLVGALRSQVSQERQRKERAEREYTAVLQ 216
Cdd:COG4942  107 aELLRAL-YRLGRQPPL-------ALLLSPEDFLDAVRRlqYLKYLAPARREQAEELRADLAELAALRAELEAERAELEA 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578830804 217 EYSELERQLCEMEACRLRVQELEAELLELQQMKQAKTYLLGPDDHLAEALLAPLTQAPEADDPQPGRGDDLGAQDGVSSP 296
Cdd:COG4942  179 LLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAERTPAAGFAALKGKLPWP 258

                        250
                 ....*....|
gi 578830804 297 AasPGHVVRK 306
Cdd:COG4942  259 V--SGRVVRR 266
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 12-225 6.76e-04

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 42.02  E-value: 6.76e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578830804   12 AEEEESWYDQQDLEQdlhLAAELGKT-------LLERNKE---LEGSLQQMYSTNEEQVQEIEYLTKQLDTLRHVNEQHA 81
Cdd:pfam05483 415 AEDEKLLDEKKQFEK---IAEELKGKeqeliflLQAREKEihdLEIQLTAIKTSEEHYLKEVEDLKTELEKEKLKNIELT 491

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578830804   82 KVYEQLDLTARDLELTNHRLVLESKAAQQKIHGLTETIERLQAQVEELQAQVEQLRglEQLRVLREKRERRRTihTFPCL 161
Cdd:pfam05483 492 AHCDKLLLENKELTQEASDMTLELKKHQEDIINCKKQEERMLKQIENLEEKEMNLR--DELESVREEFIQKGD--EVKCK 567

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 578830804  162 KELCTSPRSSLELGPRPLEQENERLQTLVGALRSQVSQERQRKERAEREYTAVLQEYSELERQL 225
Cdd:pfam05483 568 LDKSEENARSIEYEVLKKEKQMKILENKCNNLKKQIENKNKNIEELHQENKALKKKGSAENKQL 631
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
2-229 1.62e-03

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 40.82  E-value: 1.62e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578830804   2 RRAAGMEDFsaeeEESWYDQQDLEQDLHLAAELGKTLLERNKELEGSLQQMYSTNEEQVQEIEYLTKQLDTLRHVNEQHA 81
Cdd:PRK03918 152 RQILGLDDY----ENAYKNLGEVIKEIKRRIERLEKFIKRTENIEELIKEKEKELEEVLREINEISSELPELREELEKLE 227

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578830804  82 KVYEQLDLTARDLELTNHRLVL---ESKAAQQKIHGLTETIERLQAQVEELQAQVEQLRGLEqlrvlrEKRERRRTIHTF 158
Cdd:PRK03918 228 KEVKELEELKEEIEELEKELESlegSKRKLEEKIRELEERIEELKKEIEELEEKVKELKELK------EKAEEYIKLSEF 301

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 578830804 159 pclkelctspRSSLELGPRPLEQENERLQTLVGALRSQVSQERQRKERAEReytaVLQEYSELERQLCEME 229
Cdd:PRK03918 302 ----------YEEYLDELREIEKRLSRLEEEINGIEERIKELEEKEERLEE----LKKKLKELEKRLEELE 358
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 48-159 2.32e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 40.13  E-value: 2.32e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578830804  48 SLQQMYSTNEEQVQEIEYLTKQLDTLRHVNEQHAKVYEQLDLTARDLELTNHRLVLESKAAQQKIHGLTETIERLQAQVE 127
Cdd:COG4942  137 RLQYLKYLAPARREQAEELRADLAELAALRAELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELA 216

                         90       100       110
                 ....*....|....*....|....*....|...
gi 578830804 128 ELQAQVEQLRGL-EQLRVLREKRERRRTIHTFP 159
Cdd:COG4942  217 ELQQEAEELEALiARLEAEAAAAAERTPAAGFA 249
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
101-225 2.65e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 40.28  E-value: 2.65e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578830804  101 LVLESKAAQQKIHGLTE---TIERLQAQVEELQAQVEQLRGLEQLRVLREKRERRRTIHtfpclkELCTSPRSSLELgpr 177
Cdd:COG4913   216 YMLEEPDTFEAADALVEhfdDLERAHEALEDAREQIELLEPIRELAERYAAARERLAEL------EYLRAALRLWFA--- 286

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 578830804  178 plEQENERLQTLVGALRSQVSQERQRKERAEREYTAVLQEYSELERQL 225
Cdd:COG4913   287 --QRRLELLEAELEELRAELARLEAELERLEARLDALREELDELEAQI 332
COG2433 COG2433
Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];
109-210 3.09e-03

Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];


Pssm-ID: 441980 [Multi-domain]  Cd Length: 644  Bit Score: 39.84  E-value: 3.09e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578830804 109 QQKIHGLTETIERLQAQVEELQAQVEQLRG-LEQL--RVLREKRERRRTIhtfpclkelctspRSSLELgpRPLEQENER 185
Cdd:COG2433  412 EEEIRRLEEQVERLEAEVEELEAELEEKDErIERLerELSEARSEERREI-------------RKDREI--SRLDREIER 476

                         90       100
                 ....*....|....*....|....*
gi 578830804 186 lqtlvgaLRSQVSQERQRKERAERE 210
Cdd:COG2433  477 -------LERELEEERERIEELKRK 494
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 23-142 5.49e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 39.27  E-value: 5.49e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578830804    23 DLEQDLHLAAELGKTLLERNKELEGSLQQMYSTNEEQVQEIEYLTKQLDTLRHVNEQHAKVYEQLDLTARDLELTNHRLV 102
Cdd:TIGR02168  835 ATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNERASLEEALALLRSELEELSEELRELESKRSELR 914

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 578830804   103 LESKAAQQKIHGLTETIERLQAQVEELQaqvEQLRGLEQL 142
Cdd:TIGR02168  915 RELEELREKLAQLELRLEGLEVRIDNLQ---ERLSEEYSL 951
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
108-273 5.79e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 39.13  E-value: 5.79e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578830804  108 AQQKIHGLTETIERLQAQVEELQAQVEQLRglEQLRVLREKRERRRTI--HTFPCLKelctspRSSLELGPRPLEQENER 185
Cdd:COG4913   608 NRAKLAALEAELAELEEELAEAEERLEALE--AELDALQERREALQRLaeYSWDEID------VASAEREIAELEAELER 679

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578830804  186 LQT---LVGALRSQVSQERQRKERAEREYTAVLQEYSELERQLcemEACRLRVQELEAELLELQQMKQAKTYLLGpDDHL 262
Cdd:COG4913   680 LDAssdDLAALEEQLEELEAELEELEEELDELKGEIGRLEKEL---EQAEEELDELQDRLEAAEDLARLELRALL-EERF 755

                         170
                  ....*....|.
gi 578830804  263 AEALLAPLTQA 273
Cdd:COG4913   756 AAALGDAVERE 766
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 21-225 7.65e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 38.76  E-value: 7.65e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578830804  21 QQDLEQ-DLHLAAELGKTLLERNKELEGSLQQMYSTNEEQVQEIEYLTKQLDTLRHVNEQHAKVYEQLDLTARDLELTNH 99
Cdd:COG1196  219 KEELKElEAELLLLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELA 298

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578830804 100 RLVLESKAAQQKIHGLTETIERLQAQVEELQAQVEQLRglEQLRVLREKRERRRTIhtfpclkelctspRSSLELGPRPL 179
Cdd:COG1196  299 RLEQDIARLEERRRELEERLEELEEELAELEEELEELE--EELEELEEELEEAEEE-------------LEEAEAELAEA 363

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 578830804 180 EQENERLQTLVGALRSQVSQERQRKERAEREYTAVLQEYSELERQL 225
Cdd:COG1196  364 EEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAE 409
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 14-229 8.71e-03

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 38.57  E-value: 8.71e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578830804   14 EEESWYDQQDLEQDLHLAAELGKTLLERNKELEGSLQQMYSTNEEQVQEiEYLTKQLDTLRHVNEQHAKVYEQLDLTARD 93
Cdd:pfam17380 319 EEAEKARQAEMDRQAAIYAEQERMAMERERELERIRQEERKRELERIRQ-EEIAMEISRMRELERLQMERQQKNERVRQE 397

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578830804   94 LELTNHRLVLEsKAAQQKIHGLTETIERLQAQVEELQAqveqlrglEQLRVLREKRERRRTihtfpclkelctsprssle 173
Cdd:pfam17380 398 LEAARKVKILE-EERQRKIQQQKVEMEQIRAEQEEARQ--------REVRRLEEERAREME------------------- 449

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 578830804  174 lgpRPLEQENERlQTLVGALRSQVSQERQRKERAEREYTAvLQEYSELERQLCEME 229
Cdd:pfam17380 450 ---RVRLEEQER-QQQVERLRQQEEERKRKKLELEKEKRD-RKRAEEQRRKILEKE 500
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH