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Conserved domains on  [gi|664756752|ref|XP_008535883|]
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PREDICTED: centrosomal protein of 78 kDa isoform X5 [Equus przewalskii]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 1006001)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RNA1 super family cl34950
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 110-221 4.89e-10

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


The actual alignment was detected with superfamily member COG5238:

Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 62.11  E-value: 4.89e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664756752 110 KALKCCLSASGALKNLELNGLVLRERDLTMLTKGLNKSATLVNLSLANCPIGDGG-------------LETLDLQQCGLT 176
Cdd:COG5238  282 IALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQGaialakalqenttLHSLDLSDNQIG 361

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 664756752 177 NEGAKALLKALETNRTLVVLDIRKNPLVDHSVMKavIKKVLQNGR 221
Cdd:COG5238  362 DEGAIALAKYLEGNTTLRELNLGKNNIGKQGAEA--LIDALQTNR 404
 
Name Accession Description Interval E-value
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 110-221 4.89e-10

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 62.11  E-value: 4.89e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664756752 110 KALKCCLSASGALKNLELNGLVLRERDLTMLTKGLNKSATLVNLSLANCPIGDGG-------------LETLDLQQCGLT 176
Cdd:COG5238  282 IALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQGaialakalqenttLHSLDLSDNQIG 361

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 664756752 177 NEGAKALLKALETNRTLVVLDIRKNPLVDHSVMKavIKKVLQNGR 221
Cdd:COG5238  362 DEGAIALAKYLEGNTTLRELNLGKNNIGKQGAEA--LIDALQTNR 404
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 108-205 4.55e-08

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 55.44  E-value: 4.55e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664756752 108 LCKALKCCLSAsgaLKNLELNGLVLRERDLTMLTKGLNKSATLVNLSLANCPIGDGG-------------LETLDLQQCG 174
Cdd:cd00116  128 LAKGLKDLPPA---LEKLVLGRNRLEGASCEALAKALRANRDLKELNLANNGIGDAGiralaeglkancnLEVLDLNNNG 204

                         90       100       110
                 ....*....|....*....|....*....|.
gi 664756752 175 LTNEGAKALLKALETNRTLVVLDIRKNPLVD 205
Cdd:cd00116  205 LTDEGASALAETLASLKSLEVLNLGDNNLTD 235
LRR_RI smart00368
Leucine rich repeat, ribonuclease inhibitor type;
165-188 1.50e-03

Leucine rich repeat, ribonuclease inhibitor type;


Pssm-ID: 197686 [Multi-domain]  Cd Length: 28  Bit Score: 36.23  E-value: 1.50e-03
                           10        20
                   ....*....|....*....|....
gi 664756752   165 LETLDLQQCGLTNEGAKALLKALE 188
Cdd:smart00368   4 LRELDLSNNKLGDEGARALAEALK 27
 
Name Accession Description Interval E-value
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 110-221 4.89e-10

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 62.11  E-value: 4.89e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664756752 110 KALKCCLSASGALKNLELNGLVLRERDLTMLTKGLNKSATLVNLSLANCPIGDGG-------------LETLDLQQCGLT 176
Cdd:COG5238  282 IALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQGaialakalqenttLHSLDLSDNQIG 361

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 664756752 177 NEGAKALLKALETNRTLVVLDIRKNPLVDHSVMKavIKKVLQNGR 221
Cdd:COG5238  362 DEGAIALAKYLEGNTTLRELNLGKNNIGKQGAEA--LIDALQTNR 404
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 108-205 4.55e-08

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 55.44  E-value: 4.55e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664756752 108 LCKALKCCLSAsgaLKNLELNGLVLRERDLTMLTKGLNKSATLVNLSLANCPIGDGG-------------LETLDLQQCG 174
Cdd:cd00116  128 LAKGLKDLPPA---LEKLVLGRNRLEGASCEALAKALRANRDLKELNLANNGIGDAGiralaeglkancnLEVLDLNNNG 204

                         90       100       110
                 ....*....|....*....|....*....|.
gi 664756752 175 LTNEGAKALLKALETNRTLVVLDIRKNPLVD 205
Cdd:cd00116  205 LTDEGASALAETLASLKSLEVLNLGDNNLTD 235
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 107-219 9.74e-08

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 54.80  E-value: 9.74e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664756752 107 QLCKALKCCLSASGALKNLELNGLVLRERDLTMLTKGLNKSATLVNLSLANCPIGDGG-------------LETLDLQQC 173
Cdd:COG5238  195 EGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGvialaealknnttVETLYLSGN 274

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 664756752 174 GLTNEGAKALLKALETNRTLVVLDIRKNPLVDHSVmkAVIKKVLQN 219
Cdd:COG5238  275 QIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGA--IALAEGLQG 318
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 110-205 5.08e-07

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 51.97  E-value: 5.08e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664756752 110 KALKCCLSASGALKNLELngLVLRERDLTMLTKG----LNKSATLVNLSLANCPIGDGG--------------LETLDLQ 171
Cdd:cd00116   68 RGLQSLLQGLTKGCGLQE--LDLSDNALGPDGCGvlesLLRSSSLQELKLNNNGLGDRGlrllakglkdlppaLEKLVLG 145

                         90       100       110
                 ....*....|....*....|....*....|....
gi 664756752 172 QCGLTNEGAKALLKALETNRTLVVLDIRKNPLVD 205
Cdd:cd00116  146 RNRLEGASCEALAKALRANRDLKELNLANNGIGD 179
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 108-201 2.28e-05

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 46.96  E-value: 2.28e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664756752 108 LCKALKcclsASGALKNLELNGLVLRERDLTMLTKGLNKSATLVNLSLANCPIGDGG--------------LETLDLQQC 173
Cdd:cd00116  185 LAEGLK----ANCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNLTDAGaaalasallspnisLLTLSLSCN 260

                         90       100
                 ....*....|....*....|....*...
gi 664756752 174 GLTNEGAKALLKALETNRTLVVLDIRKN 201
Cdd:cd00116  261 DITDDGAKDLAEVLAEKESLLELDLRGN 288
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 115-225 1.55e-04

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 44.78  E-value: 1.55e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664756752 115 CLSASGALKN-----LELNGLVLRERDLTMLTKGLNKSATLVNLSLANCPIGDGGLE-------------TLDLQQCGLT 176
Cdd:COG5238  170 AISMAKALQNnsvetVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEilaealkgnksltTLDLSNNQIG 249

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 664756752 177 NEGAKALLKALETNRTLVVLDIRKNPlVDHSVMKAVIkKVLQNGRSAKS 225
Cdd:COG5238  250 DEGVIALAEALKNNTTVETLYLSGNQ-IGAEGAIALA-KALQGNTTLTS 296
LRR_RI smart00368
Leucine rich repeat, ribonuclease inhibitor type;
165-188 1.50e-03

Leucine rich repeat, ribonuclease inhibitor type;


Pssm-ID: 197686 [Multi-domain]  Cd Length: 28  Bit Score: 36.23  E-value: 1.50e-03
                           10        20
                   ....*....|....*....|....
gi 664756752   165 LETLDLQQCGLTNEGAKALLKALE 188
Cdd:smart00368   4 LRELDLSNNKLGDEGARALAEALK 27
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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