Hermansky-Pudlak syndrome 3, middle region; This domain is downstream of the N-terminus of ...
255-640
0e+00
Hermansky-Pudlak syndrome 3, middle region; This domain is downstream of the N-terminus of these vertebrate proteins. This region carries a number of tyrosine sorting motifs and one of two di-leucine sorting boxes at residues 542-548 well as a peroxisomal matrix targetting motif at residues 614-623 in SwissProt:Q969F9. There is also reference to a human Mendelian disease at MIM:614072.
:
Pssm-ID: 464301 Cd Length: 385 Bit Score: 612.47 E-value: 0e+00
Hermansky-Pudlak syndrome 3, C-terminal; This domain is downstream of the mid domain family, ...
649-960
0e+00
Hermansky-Pudlak syndrome 3, C-terminal; This domain is downstream of the mid domain family, pfam14762, of these vertebrate proteins. This region carries a number of tyrosine sorting motifs and the second of two di-leucine sorting boxes at residues 711-717 well as the ER membrane-retention signal KKPL at residues 1000-1003 in SwissProt:Q969F9. There is also reference to a human Mendelian disease at MIM:614072.
The actual alignment was detected with superfamily member pfam14763:
Pssm-ID: 464302 Cd Length: 352 Bit Score: 557.37 E-value: 0e+00
Hermansky-Pudlak syndrome 3; This domain is at the N-terminus of these vertebrate proteins. ...
3-212
3.91e-93
Hermansky-Pudlak syndrome 3; This domain is at the N-terminus of these vertebrate proteins. This region carries the clathrin-binding motif LLDFE at residues 172-176 in SwissProt:Q969F9. There is also reference to a human Mendelian disease at MIM:614072.
:
Pssm-ID: 464300 Cd Length: 211 Bit Score: 294.98 E-value: 3.91e-93
Hermansky-Pudlak syndrome 3, middle region; This domain is downstream of the N-terminus of ...
255-640
0e+00
Hermansky-Pudlak syndrome 3, middle region; This domain is downstream of the N-terminus of these vertebrate proteins. This region carries a number of tyrosine sorting motifs and one of two di-leucine sorting boxes at residues 542-548 well as a peroxisomal matrix targetting motif at residues 614-623 in SwissProt:Q969F9. There is also reference to a human Mendelian disease at MIM:614072.
Pssm-ID: 464301 Cd Length: 385 Bit Score: 612.47 E-value: 0e+00
Hermansky-Pudlak syndrome 3, C-terminal; This domain is downstream of the mid domain family, ...
649-960
0e+00
Hermansky-Pudlak syndrome 3, C-terminal; This domain is downstream of the mid domain family, pfam14762, of these vertebrate proteins. This region carries a number of tyrosine sorting motifs and the second of two di-leucine sorting boxes at residues 711-717 well as the ER membrane-retention signal KKPL at residues 1000-1003 in SwissProt:Q969F9. There is also reference to a human Mendelian disease at MIM:614072.
Pssm-ID: 464302 Cd Length: 352 Bit Score: 557.37 E-value: 0e+00
Hermansky-Pudlak syndrome 3; This domain is at the N-terminus of these vertebrate proteins. ...
3-212
3.91e-93
Hermansky-Pudlak syndrome 3; This domain is at the N-terminus of these vertebrate proteins. This region carries the clathrin-binding motif LLDFE at residues 172-176 in SwissProt:Q969F9. There is also reference to a human Mendelian disease at MIM:614072.
Pssm-ID: 464300 Cd Length: 211 Bit Score: 294.98 E-value: 3.91e-93
Hermansky-Pudlak syndrome 3, middle region; This domain is downstream of the N-terminus of ...
255-640
0e+00
Hermansky-Pudlak syndrome 3, middle region; This domain is downstream of the N-terminus of these vertebrate proteins. This region carries a number of tyrosine sorting motifs and one of two di-leucine sorting boxes at residues 542-548 well as a peroxisomal matrix targetting motif at residues 614-623 in SwissProt:Q969F9. There is also reference to a human Mendelian disease at MIM:614072.
Pssm-ID: 464301 Cd Length: 385 Bit Score: 612.47 E-value: 0e+00
Hermansky-Pudlak syndrome 3, C-terminal; This domain is downstream of the mid domain family, ...
649-960
0e+00
Hermansky-Pudlak syndrome 3, C-terminal; This domain is downstream of the mid domain family, pfam14762, of these vertebrate proteins. This region carries a number of tyrosine sorting motifs and the second of two di-leucine sorting boxes at residues 711-717 well as the ER membrane-retention signal KKPL at residues 1000-1003 in SwissProt:Q969F9. There is also reference to a human Mendelian disease at MIM:614072.
Pssm-ID: 464302 Cd Length: 352 Bit Score: 557.37 E-value: 0e+00
Hermansky-Pudlak syndrome 3; This domain is at the N-terminus of these vertebrate proteins. ...
3-212
3.91e-93
Hermansky-Pudlak syndrome 3; This domain is at the N-terminus of these vertebrate proteins. This region carries the clathrin-binding motif LLDFE at residues 172-176 in SwissProt:Q969F9. There is also reference to a human Mendelian disease at MIM:614072.
Pssm-ID: 464300 Cd Length: 211 Bit Score: 294.98 E-value: 3.91e-93
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
of the residues that compose this conserved feature have been mapped to the query sequence.
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if a domain or superfamily has been annotated with functional sites (conserved features),
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The table lists conserved domains identified on the query sequence. Click on the plus sign (+) on the left to display full descriptions, alignments, and scores.
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(labeled illustration) Standard Display shows only the best scoring domain model from each source, in each hit category listed below for each region on the query sequence.
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