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Conserved domains on  [gi|672046998|ref|XP_008760425|]
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fibrillin-1 isoform X1 [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Fibrillin_U_N pfam18193
Fibrillin 1 unique N-terminal domain; This is the N-terminal domain of human fibrillin-1. ...
 48-82 3.22e-12

Fibrillin 1 unique N-terminal domain; This is the N-terminal domain of human fibrillin-1. Fibrillin is a primary constituent of microfibrils in the extracellular matrix of many elastic and non-elastic connective tissues. This domain, known as the fibrillin unique N-terminal (FUN) domain, constitutes the minimal interaction site for the fibrillin C terminus. The FUN domain has homologs in the human proteins LTBP-1L/2 and VWCE, which are also associated with a C-terminal EGF-like domain.


:

Pssm-ID: 436338  Cd Length: 37  Bit Score: 62.99  E-value: 3.22e-12
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 672046998    48 GGHDALKGPNVCGSRYNAYCCPGWKTLPGGNQCIV 82
Cdd:pfam18193    3 GGADVLRGPNVCGSRFHAYCCPGWKTLPGGNQCIV 37
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 669-712 3.26e-11

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


:

Pssm-ID: 459903  Cd Length: 44  Bit Score: 60.37  E-value: 3.26e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 672046998   669 GQCVKPLFGAVTKSECCCASTEYAFGEPCQPCPAQNSAEYQALC 712
Cdd:pfam00683    1 GRCSNPLPGNVTKSECCCTSVGRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 2069-2112 8.51e-11

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


:

Pssm-ID: 459903  Cd Length: 44  Bit Score: 59.21  E-value: 8.51e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 672046998  2069 GKCSSPKSRNHSKQECCCALKGEGWGDPCELCPTEPDEAFRQIC 2112
Cdd:pfam00683    1 GRCSNPLPGNVTKSECCCTSVGRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 1550-1590 2.00e-09

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


:

Pssm-ID: 459903  Cd Length: 44  Bit Score: 54.98  E-value: 2.00e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 672046998  1550 CSNEIGVGVSKASCCC-SLGKAWGTPCELCPPVNTSEYKILC 1590
Cdd:pfam00683    3 CSNPLPGNVTKSECCCtSVGRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 1706-1749 2.44e-09

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


:

Pssm-ID: 459903  Cd Length: 44  Bit Score: 54.98  E-value: 2.44e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 672046998  1706 TCDGELLFNMTKKMCCCSYnIGRAWNKPCEQCPIPSTDEFATLC 1749
Cdd:pfam00683    2 RCSNPLPGNVTKSECCCTS-VGRAWGSPCELCPPPGTDEFRELC 44
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 1368-1403 6.84e-09

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


:

Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 53.37  E-value: 6.84e-09
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 672046998  1368 CSNGTHMCSQHADCKNTMGSYRCLCKDGYTGDGFTC 1403
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGGSFTCTCNDGYTGDGVTC 36
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 343-389 5.53e-08

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


:

Pssm-ID: 459903  Cd Length: 44  Bit Score: 51.12  E-value: 5.53e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 672046998   343 GRCSNQLPQSITKMQCCCD-VGRCWSPGvtvaPEMCPIRSTEDFNKLC 389
Cdd:pfam00683    1 GRCSNPLPGNVTKSECCCTsVGRAWGSP----CELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 2358-2391 8.94e-08

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


:

Pssm-ID: 459903  Cd Length: 44  Bit Score: 50.35  E-value: 8.94e-08
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 672046998  2358 PVTKSECCCD-GGRGWGPHCEICPFEGTVAYKKLC 2391
Cdd:pfam00683   10 NVTKSECCCTsVGRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 967-1009 4.55e-07

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


:

Pssm-ID: 459903  Cd Length: 44  Bit Score: 48.43  E-value: 4.55e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 672046998   967 ECTLPIAGRHRMDACCC-SVGAAWGtEECEECPLRNSREYEELC 1009
Cdd:pfam00683    2 RCSNPLPGNVTKSECCCtSVGRAWG-SPCELCPPPGTDEFRELC 44
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 1327-1362 9.51e-07

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


:

Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 47.21  E-value: 9.51e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 672046998  1327 CEIGAHNCGRHAVCTNTAGSFKCSCSPGWIGDGIKC 1362
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGGSFTCTCNDGYTGDGVTC 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
1809-1841 3.21e-06

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.09  E-value: 3.21e-06
                            10        20        30
                    ....*....|....*....|....*....|...
gi 672046998   1809 DIDECQNGPVCQRNAECINTAGSYRCDCKPGYR 1841
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT 33
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 1202-1237 4.35e-06

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 45.31  E-value: 4.35e-06
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 672046998  1202 CSIMNGGCETFCTNSDGSYECSCQPGFALMPDQRSC 1237
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
531-572 2.05e-05

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.77  E-value: 2.05e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 672046998    531 DIDECLQNGRICNNGRCINTDGSFHCVCNAGFHvtrDGKNCE 572
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
614-647 7.22e-05

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.23  E-value: 7.22e-05
                            10        20        30
                    ....*....|....*....|....*....|....*
gi 672046998    614 DINECETPGICMNG-RCVNTDGSYRCECFPGLAVG 647
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYTDG 35
EGF_CA smart00179
Calcium-binding EGF-like domain;
1931-1973 9.14e-05

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.85  E-value: 9.14e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 672046998   1931 DVDECATGNgnLCRNG-QCVNTVGSFQCRCNEGYEvapDGRTCV 1973
Cdd:smart00179    1 DIDECASGN--PCQNGgTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA pfam07645
Calcium-binding EGF domain;
2486-2515 1.12e-04

Calcium-binding EGF domain;


:

Pssm-ID: 429571  Cd Length: 32  Bit Score: 41.45  E-value: 1.12e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 672046998  2486 DLDECATKQHNCQ--FLCVNTIGGFTCKCPPG 2515
Cdd:pfam07645    1 DVDECATGTHNCPanTVCVNTIGSFECRCPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
2128-2166 1.51e-04

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.08  E-value: 1.51e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 672046998   2128 DMDECKEPDVCKHG-QCINTDGSYRCECPFGYIlEGNECV 2166
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT-DGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
2167-2206 1.68e-04

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.08  E-value: 1.68e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 672046998   2167 DTDECSVGNPCGNG-TCKNVIGGFECTCEEGFEPGpmMTCE 2206
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYTDG--RNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
2608-2639 1.93e-04

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.08  E-value: 1.93e-04
                            10        20        30
                    ....*....|....*....|....*....|...
gi 672046998   2608 DENECLSAHVCG-GASCHNTLGSYKCMCPAGFQ 2639
Cdd:smart00179    1 DIDECASGNPCQnGGTCVNTVGSYRCECPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
2568-2597 2.35e-04

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.69  E-value: 2.35e-04
                            10        20        30
                    ....*....|....*....|....*....|..
gi 672046998   2568 DVDECEGNHRCQHG--CQNIIGGYRCSCPQGY 2597
Cdd:smart00179    1 DIDECASGNPCQNGgtCVNTVGSYRCECPPGY 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
573-613 3.84e-04

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.92  E-value: 3.84e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 672046998    573 DMDECSIRNMCLNG-MCINEDGSFKCICKPGFQlasDGRYCK 613
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
1649-1688 4.53e-04

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.92  E-value: 4.53e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 672046998   1649 DVNECETPGICGPG-TCYNTVGNYTCICPPDYMQvngGNNC 1688
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYTD---GRNC 38
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 861-891 5.56e-04

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


:

Pssm-ID: 459903  Cd Length: 44  Bit Score: 39.95  E-value: 5.56e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 672046998   861 GRCEININGATLKSECC-SSLGAAWGSPCTIC 891
Cdd:pfam00683    1 GRCSNPLPGNVTKSECCcTSVGRAWGSPCELC 32
vWFA super family cl00057
Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation ...
 2443-2483 7.34e-04

Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of fold. The vWA domain, since its discovery, has drawn great interest because of its widespread occurrence and its involvement in a wide variety of important cellular functions. These include basal membrane formation, cell migration, cell differentiation, adhesion, haemostasis, signaling, chromosomal stability, malignant transformation and in immune defenses In integrins these domains form heterodimers while in vWF it forms multimers. There are different interaction surfaces of this domain as seen by the various molecules it complexes with. Ligand binding in most cases is mediated by the presence of a metal ion dependent adhesion site termed as the MIDAS motif that is a characteristic feature of most, if not all A domains.


The actual alignment was detected with superfamily member cd01475:

Pssm-ID: 469594 [Multi-domain]  Cd Length: 224  Bit Score: 43.53  E-value: 7.34e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 672046998 2443 CVDLNECNQAPKPCNFICKNTEGSYQCSCPKGYILQEDGRS 2483
Cdd:cd01475   184 CVVPDLCATLSHVCQQVCISTPGSYLCACTEGYALLEDNKT 224
EGF_CA smart00179
Calcium-binding EGF-like domain;
1114-1150 8.76e-04

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.15  E-value: 8.76e-04
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 672046998   1114 DIDECQRDPLLCRGGICHNTEGSYRCECPSGHQLSPN 1150
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYTDGRN 37
EGF_CA pfam07645
Calcium-binding EGF domain;
2014-2044 9.93e-04

Calcium-binding EGF domain;


:

Pssm-ID: 429571  Cd Length: 32  Bit Score: 38.76  E-value: 9.93e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 672046998  2014 DIDECVEEPEICALGT-CSNTEGSFKCLCPEG 2044
Cdd:pfam07645    1 DVDECATGTHNCPANTvCVNTIGSFECRCPDG 32
EGF_CA pfam07645
Calcium-binding EGF domain;
1767-1797 1.03e-03

Calcium-binding EGF domain;


:

Pssm-ID: 429571  Cd Length: 32  Bit Score: 38.76  E-value: 1.03e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 672046998  1767 DIDECREIPGVC-ENGVCINMVGSFRCECPVG 1797
Cdd:pfam07645    1 DVDECATGTHNCpANTVCVNTIGSFECRCPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
288-329 1.20e-03

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.77  E-value: 1.20e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 672046998    288 DIDECSTIPGVCDGGECTNTVSSYFCKCPPGFYtspDGTRCV 329
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
1607-1639 1.29e-03

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.77  E-value: 1.29e-03
                            10        20        30
                    ....*....|....*....|....*....|...
gi 672046998   1607 DIDECQELPGLCQGGKCINTFGSFQCRCPTGYY 1639
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
1488-1519 1.43e-03

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.38  E-value: 1.43e-03
                            10        20        30
                    ....*....|....*....|....*....|...
gi 672046998   1488 DVNECLDPTTCISG-NCVNTPGSYTCDCPPDFE 1519
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1974-2009 2.13e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.00  E-value: 2.13e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 672046998 1974 DINECVLDPGKCAPGTCQNLDGSYRCICPPGYSLQN 2009
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGRN 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
1447-1487 2.46e-03

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.00  E-value: 2.46e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 672046998   1447 DINECSLPNICVFG-TCHNLPGLFRCECEIGYEldrSGGNCT 1487
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
2525-2567 2.59e-03

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.61  E-value: 2.59e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 672046998   2525 DNNECTSEiNLCGSKGVCQNTPGSFTCECQRGFsldQSGASCE 2567
Cdd:smart00179    1 DIDECASG-NPCQNGGTCVNTVGSYRCECPPGY---TDGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
766-797 2.80e-03

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.61  E-value: 2.80e-03
                            10        20        30
                    ....*....|....*....|....*....|..
gi 672046998    766 DINECVLNSLLCDNGQCRNTPGSFVCTCPKGF 797
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGY 32
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 194-227 2.94e-03

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


:

Pssm-ID: 459903  Cd Length: 44  Bit Score: 37.64  E-value: 2.94e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 672046998   194 MCQGQLSGIVCTKTLCCATVGRAWGHPCEMCPAQ 227
Cdd:pfam00683    2 RCSNPLPGNVTKSECCCTSVGRAWGSPCELCPPP 35
EGF_CA smart00179
Calcium-binding EGF-like domain;
1071-1105 4.81e-03

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.84  E-value: 4.81e-03
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 672046998   1071 DIDECRiSPDLCGRG-QCVNTPGDFECKCDEGYESG 1105
Cdd:smart00179    1 DIDECA-SGNPCQNGgTCVNTVGSYRCECPPGYTDG 35
EGF_CA smart00179
Calcium-binding EGF-like domain;
246-276 7.00e-03

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.46  E-value: 7.00e-03
                            10        20        30
                    ....*....|....*....|....*....|..
gi 672046998    246 DVDECqAIPGLCQ-GGNCINTVGSFECKCPAG 276
Cdd:smart00179    1 DIDEC-ASGNPCQnGGTCVNTVGSYRCECPPG 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
491-522 7.06e-03

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.46  E-value: 7.06e-03
                            10        20        30
                    ....*....|....*....|....*....|....
gi 672046998    491 DVDECE-KNPC-TGGECINNQGSYTCHCRAGYQS 522
Cdd:smart00179    1 DIDECAsGNPCqNGGTCVNTVGSYRCECPPGYTD 34
EGF_CA super family cl21504
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 911-941 9.08e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


The actual alignment was detected with superfamily member pfam07645:

Pssm-ID: 473889  Cd Length: 32  Bit Score: 36.06  E-value: 9.08e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 672046998   911 DINECEVFPGVC-KNGLCVNSRGSFKCECPSG 941
Cdd:pfam07645    1 DVDECATGTHNCpANTVCVNTIGSFECRCPDG 32
 
Name Accession Description Interval E-value
Fibrillin_U_N pfam18193
Fibrillin 1 unique N-terminal domain; This is the N-terminal domain of human fibrillin-1. ...
 48-82 3.22e-12

Fibrillin 1 unique N-terminal domain; This is the N-terminal domain of human fibrillin-1. Fibrillin is a primary constituent of microfibrils in the extracellular matrix of many elastic and non-elastic connective tissues. This domain, known as the fibrillin unique N-terminal (FUN) domain, constitutes the minimal interaction site for the fibrillin C terminus. The FUN domain has homologs in the human proteins LTBP-1L/2 and VWCE, which are also associated with a C-terminal EGF-like domain.


Pssm-ID: 436338  Cd Length: 37  Bit Score: 62.99  E-value: 3.22e-12
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 672046998    48 GGHDALKGPNVCGSRYNAYCCPGWKTLPGGNQCIV 82
Cdd:pfam18193    3 GGADVLRGPNVCGSRFHAYCCPGWKTLPGGNQCIV 37
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 669-712 3.26e-11

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 60.37  E-value: 3.26e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 672046998   669 GQCVKPLFGAVTKSECCCASTEYAFGEPCQPCPAQNSAEYQALC 712
Cdd:pfam00683    1 GRCSNPLPGNVTKSECCCTSVGRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 2069-2112 8.51e-11

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 59.21  E-value: 8.51e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 672046998  2069 GKCSSPKSRNHSKQECCCALKGEGWGDPCELCPTEPDEAFRQIC 2112
Cdd:pfam00683    1 GRCSNPLPGNVTKSECCCTSVGRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 1550-1590 2.00e-09

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 54.98  E-value: 2.00e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 672046998  1550 CSNEIGVGVSKASCCC-SLGKAWGTPCELCPPVNTSEYKILC 1590
Cdd:pfam00683    3 CSNPLPGNVTKSECCCtSVGRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 1706-1749 2.44e-09

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 54.98  E-value: 2.44e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 672046998  1706 TCDGELLFNMTKKMCCCSYnIGRAWNKPCEQCPIPSTDEFATLC 1749
Cdd:pfam00683    2 RCSNPLPGNVTKSECCCTS-VGRAWGSPCELCPPPGTDEFRELC 44
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 1368-1403 6.84e-09

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 53.37  E-value: 6.84e-09
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 672046998  1368 CSNGTHMCSQHADCKNTMGSYRCLCKDGYTGDGFTC 1403
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGGSFTCTCNDGYTGDGVTC 36
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 343-389 5.53e-08

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 51.12  E-value: 5.53e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 672046998   343 GRCSNQLPQSITKMQCCCD-VGRCWSPGvtvaPEMCPIRSTEDFNKLC 389
Cdd:pfam00683    1 GRCSNPLPGNVTKSECCCTsVGRAWGSP----CELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 2358-2391 8.94e-08

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 50.35  E-value: 8.94e-08
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 672046998  2358 PVTKSECCCD-GGRGWGPHCEICPFEGTVAYKKLC 2391
Cdd:pfam00683   10 NVTKSECCCTsVGRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 967-1009 4.55e-07

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 48.43  E-value: 4.55e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 672046998   967 ECTLPIAGRHRMDACCC-SVGAAWGtEECEECPLRNSREYEELC 1009
Cdd:pfam00683    2 RCSNPLPGNVTKSECCCtSVGRAWG-SPCELCPPPGTDEFRELC 44
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 1327-1362 9.51e-07

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 47.21  E-value: 9.51e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 672046998  1327 CEIGAHNCGRHAVCTNTAGSFKCSCSPGWIGDGIKC 1362
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGGSFTCTCNDGYTGDGVTC 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
1809-1841 3.21e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.09  E-value: 3.21e-06
                            10        20        30
                    ....*....|....*....|....*....|...
gi 672046998   1809 DIDECQNGPVCQRNAECINTAGSYRCDCKPGYR 1841
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1809-1844 3.49e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.71  E-value: 3.49e-06
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 672046998 1809 DIDECQNGPVCQRNAECINTAGSYRCDCKPGYRLTS 1844
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGRN 36
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 1202-1237 4.35e-06

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 45.31  E-value: 4.35e-06
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 672046998  1202 CSIMNGGCETFCTNSDGSYECSCQPGFALMPDQRSC 1237
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 1195-1236 5.53e-06

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 50.08  E-value: 5.53e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 672046998 1195 FCVDIDECSIMNGGCETFCTNSDGSYECSCQPGFALMPDQRS 1236
Cdd:cd01475   183 ICVVPDLCATLSHVCQQVCISTPGSYLCACTEGYALLEDNKT 224
EGF_CA smart00179
Calcium-binding EGF-like domain;
531-572 2.05e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.77  E-value: 2.05e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 672046998    531 DIDECLQNGRICNNGRCINTDGSFHCVCNAGFHvtrDGKNCE 572
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 531-572 7.11e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.24  E-value: 7.11e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 672046998  531 DIDECLQNGRICNNGRCINTDGSFHCVCNAGFHvtrdGKNCE 572
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYT----GRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
614-647 7.22e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.23  E-value: 7.22e-05
                            10        20        30
                    ....*....|....*....|....*....|....*
gi 672046998    614 DINECETPGICMNG-RCVNTDGSYRCECFPGLAVG 647
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYTDG 35
EGF_CA smart00179
Calcium-binding EGF-like domain;
1931-1973 9.14e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.85  E-value: 9.14e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 672046998   1931 DVDECATGNgnLCRNG-QCVNTVGSFQCRCNEGYEvapDGRTCV 1973
Cdd:smart00179    1 DIDECASGN--PCQNGgTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA pfam07645
Calcium-binding EGF domain;
2486-2515 1.12e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 41.45  E-value: 1.12e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 672046998  2486 DLDECATKQHNCQ--FLCVNTIGGFTCKCPPG 2515
Cdd:pfam07645    1 DVDECATGTHNCPanTVCVNTIGSFECRCPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
2128-2166 1.51e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.08  E-value: 1.51e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 672046998   2128 DMDECKEPDVCKHG-QCINTDGSYRCECPFGYIlEGNECV 2166
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT-DGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
2167-2206 1.68e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.08  E-value: 1.68e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 672046998   2167 DTDECSVGNPCGNG-TCKNVIGGFECTCEEGFEPGpmMTCE 2206
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYTDG--RNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
2608-2639 1.93e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.08  E-value: 1.93e-04
                            10        20        30
                    ....*....|....*....|....*....|...
gi 672046998   2608 DENECLSAHVCG-GASCHNTLGSYKCMCPAGFQ 2639
Cdd:smart00179    1 DIDECASGNPCQnGGTCVNTVGSYRCECPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
2568-2597 2.35e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.69  E-value: 2.35e-04
                            10        20        30
                    ....*....|....*....|....*....|..
gi 672046998   2568 DVDECEGNHRCQHG--CQNIIGGYRCSCPQGY 2597
Cdd:smart00179    1 DIDECASGNPCQNGgtCVNTVGSYRCECPPGY 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 614-643 3.04e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.31  E-value: 3.04e-04
                          10        20        30
                  ....*....|....*....|....*....|.
gi 672046998  614 DINECETPGICMN-GRCVNTDGSYRCECFPG 643
Cdd:cd00054     1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPG 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
1364-1404 3.38e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.31  E-value: 3.38e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 672046998   1364 DLDECSNGtHMCSQHADCKNTMGSYRCLCKDGYTgDGFTCT 1404
Cdd:smart00179    1 DIDECASG-NPCQNGGTCVNTVGSYRCECPPGYT-DGRNCE 39
EGF_CA pfam07645
Calcium-binding EGF domain;
1931-1962 3.47e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 39.91  E-value: 3.47e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 672046998  1931 DVDECATGNGNLCRNGQCVNTVGSFQCRCNEG 1962
Cdd:pfam07645    1 DVDECATGTHNCPANTVCVNTIGSFECRCPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 2128-2160 3.74e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.93  E-value: 3.74e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 672046998 2128 DMDECKEPDVCK-HGQCINTDGSYRCECPFGYIL 2160
Cdd:cd00054     1 DIDECASGNPCQnGGTCVNTVGSYRCSCPPGYTG 34
EGF_CA smart00179
Calcium-binding EGF-like domain;
573-613 3.84e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.92  E-value: 3.84e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 672046998    573 DMDECSIRNMCLNG-MCINEDGSFKCICKPGFQlasDGRYCK 613
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA pfam07645
Calcium-binding EGF domain;
1809-1839 4.10e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 39.91  E-value: 4.10e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 672046998  1809 DIDECQNGP-VCQRNAECINTAGSYRCDCKPG 1839
Cdd:pfam07645    1 DVDECATGThNCPANTVCVNTIGSFECRCPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
1649-1688 4.53e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.92  E-value: 4.53e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 672046998   1649 DVNECETPGICGPG-TCYNTVGNYTCICPPDYMQvngGNNC 1688
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYTD---GRNC 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1323-1358 4.92e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.93  E-value: 4.92e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 672046998 1323 DINECEIGaHNCGRHAVCTNTAGSFKCSCSPGWIGD 1358
Cdd:cd00054     1 DIDECASG-NPCQNGGTCVNTVGSYRCSCPPGYTGR 35
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 861-891 5.56e-04

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 39.95  E-value: 5.56e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 672046998   861 GRCEININGATLKSECC-SSLGAAWGSPCTIC 891
Cdd:pfam00683    1 GRCSNPLPGNVTKSECCcTSVGRAWGSPCELC 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1364-1399 6.88e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.16  E-value: 6.88e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 672046998 1364 DLDECSNGtHMCSQHADCKNTMGSYRCLCKDGYTGD 1399
Cdd:cd00054     1 DIDECASG-NPCQNGGTCVNTVGSYRCSCPPGYTGR 35
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 2443-2483 7.34e-04

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 43.53  E-value: 7.34e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 672046998 2443 CVDLNECNQAPKPCNFICKNTEGSYQCSCPKGYILQEDGRS 2483
Cdd:cd01475   184 CVVPDLCATLSHVCQQVCISTPGSYLCACTEGYALLEDNKT 224
EGF_CA smart00179
Calcium-binding EGF-like domain;
1323-1363 7.94e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.15  E-value: 7.94e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 672046998   1323 DINECEIGaHNCGRHAVCTNTAGSFKCSCSPGWIgDGIKCT 1363
Cdd:smart00179    1 DIDECASG-NPCQNGGTCVNTVGSYRCECPPGYT-DGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
1114-1150 8.76e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.15  E-value: 8.76e-04
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 672046998   1114 DIDECQRDPLLCRGGICHNTEGSYRCECPSGHQLSPN 1150
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYTDGRN 37
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 1926-1971 8.89e-04

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 43.53  E-value: 8.89e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 672046998 1926 NNDCIDVDECATGNGNlCRNGqCVNTVGSFQCRCNEGYEVAPDGRT 1971
Cdd:cd01475   181 GKICVVPDLCATLSHV-CQQV-CISTPGSYLCACTEGYALLEDNKT 224
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 2608-2639 9.06e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.16  E-value: 9.06e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 672046998 2608 DENECLSAHVCG-GASCHNTLGSYKCMCPAGFQ 2639
Cdd:cd00054     1 DIDECASGNPCQnGGTCVNTVGSYRCSCPPGYT 33
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 2449-2484 9.17e-04

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 38.76  E-value: 9.17e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 672046998  2449 CNQAPKPCNFICKNTEGSYQCSCPKGYILQEDGRSC 2484
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
EGF_CA pfam07645
Calcium-binding EGF domain;
2014-2044 9.93e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 38.76  E-value: 9.93e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 672046998  2014 DIDECVEEPEICALGT-CSNTEGSFKCLCPEG 2044
Cdd:pfam07645    1 DVDECATGTHNCPANTvCVNTIGSFECRCPDG 32
EGF_CA pfam07645
Calcium-binding EGF domain;
1767-1797 1.03e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 38.76  E-value: 1.03e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 672046998  1767 DIDECREIPGVC-ENGVCINMVGSFRCECPVG 1797
Cdd:pfam07645    1 DVDECATGTHNCpANTVCVNTIGSFECRCPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 2568-2597 1.19e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.77  E-value: 1.19e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 672046998 2568 DVDECEGNHRCQHG--CQNIIGGYRCSCPQGY 2597
Cdd:cd00054     1 DIDECASGNPCQNGgtCVNTVGSYRCSCPPGY 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
288-329 1.20e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.77  E-value: 1.20e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 672046998    288 DIDECSTIPGVCDGGECTNTVSSYFCKCPPGFYtspDGTRCV 329
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
1607-1639 1.29e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.77  E-value: 1.29e-03
                            10        20        30
                    ....*....|....*....|....*....|...
gi 672046998   1607 DIDECQELPGLCQGGKCINTFGSFQCRCPTGYY 1639
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 2167-2198 1.33e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.39  E-value: 1.33e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 672046998 2167 DTDECSVGNPCGN-GTCKNVIGGFECTCEEGFE 2198
Cdd:cd00054     1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
1488-1519 1.43e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.38  E-value: 1.43e-03
                            10        20        30
                    ....*....|....*....|....*....|...
gi 672046998   1488 DVNECLDPTTCISG-NCVNTPGSYTCDCPPDFE 1519
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1114-1147 1.65e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.39  E-value: 1.65e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 672046998 1114 DIDECQRDPLLCRGGICHNTEGSYRCECPSGHQL 1147
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTG 34
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 573-607 1.82e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.00  E-value: 1.82e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 672046998  573 DMDECSIRNMCLN-GMCINEDGSFKCICKPGFQLAS 607
Cdd:cd00054     1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGYTGRN 36
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1488-1520 1.99e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.00  E-value: 1.99e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 672046998 1488 DVNECLDPTTC-ISGNCVNTPGSYTCDCPPDFEL 1520
Cdd:cd00054     1 DIDECASGNPCqNGGTCVNTVGSYRCSCPPGYTG 34
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1974-2009 2.13e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.00  E-value: 2.13e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 672046998 1974 DINECVLDPGKCAPGTCQNLDGSYRCICPPGYSLQN 2009
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGRN 36
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 2481-2517 2.15e-03

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 42.37  E-value: 2.15e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 672046998 2481 GRSCKDLDECATKQHNCQFLCVNTIGGFTCKCPPGFT 2517
Cdd:cd01475   181 GKICVVPDLCATLSHVCQQVCISTPGSYLCACTEGYA 217
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1649-1680 2.15e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.00  E-value: 2.15e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 672046998 1649 DVNECETPGICGP-GTCYNTVGNYTCICPPDYM 1680
Cdd:cd00054     1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
1447-1487 2.46e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.00  E-value: 2.46e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 672046998   1447 DINECSLPNICVFG-TCHNLPGLFRCECEIGYEldrSGGNCT 1487
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
2525-2567 2.59e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.61  E-value: 2.59e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 672046998   2525 DNNECTSEiNLCGSKGVCQNTPGSFTCECQRGFsldQSGASCE 2567
Cdd:smart00179    1 DIDECASG-NPCQNGGTCVNTVGSYRCECPPGY---TDGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
1767-1798 2.66e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.61  E-value: 2.66e-03
                            10        20        30
                    ....*....|....*....|....*....|...
gi 672046998   1767 DIDECrEIPGVCENG-VCINMVGSFRCECPVGF 1798
Cdd:smart00179    1 DIDEC-ASGNPCQNGgTCVNTVGSYRCECPPGY 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
766-797 2.80e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.61  E-value: 2.80e-03
                            10        20        30
                    ....*....|....*....|....*....|..
gi 672046998    766 DINECVLNSLLCDNGQCRNTPGSFVCTCPKGF 797
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGY 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 766-807 2.89e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.62  E-value: 2.89e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 672046998  766 DINECVLNSLLCDNGQCRNTPGSFVCTCPKGFVykpdLKTCE 807
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYT----GRNCE 38
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 194-227 2.94e-03

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 37.64  E-value: 2.94e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 672046998   194 MCQGQLSGIVCTKTLCCATVGRAWGHPCEMCPAQ 227
Cdd:pfam00683    2 RCSNPLPGNVTKSECCCTSVGRAWGSPCELCPPP 35
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1447-1481 3.59e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.23  E-value: 3.59e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 672046998 1447 DINECSLPNICVF-GTCHNLPGLFRCECEIGYELDR 1481
Cdd:cd00054     1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGYTGRN 36
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1607-1640 4.29e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.23  E-value: 4.29e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 672046998 1607 DIDECQELPGLCQGGKCINTFGSFQCRCPTGYYL 1640
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTG 34
EGF_CA smart00179
Calcium-binding EGF-like domain;
1974-2006 4.81e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.84  E-value: 4.81e-03
                            10        20        30
                    ....*....|....*....|....*....|....
gi 672046998   1974 DINECvLDPGKCAPG-TCQNLDGSYRCICPPGYS 2006
Cdd:smart00179    1 DIDEC-ASGNPCQNGgTCVNTVGSYRCECPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
1071-1105 4.81e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.84  E-value: 4.81e-03
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 672046998   1071 DIDECRiSPDLCGRG-QCVNTPGDFECKCDEGYESG 1105
Cdd:smart00179    1 DIDECA-SGNPCQNGgTCVNTVGSYRCECPPGYTDG 35
EGF_CA smart00179
Calcium-binding EGF-like domain;
2014-2055 5.52e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.84  E-value: 5.52e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 672046998   2014 DIDECVEEPEICALGTCSNTEGSFKCLCPEGFslsSTGRRCQ 2055
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGY---TDGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1767-1798 6.30e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.46  E-value: 6.30e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 672046998 1767 DIDECREIPGVCENGVCINMVGSFRCECPVGF 1798
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGY 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
246-276 7.00e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.46  E-value: 7.00e-03
                            10        20        30
                    ....*....|....*....|....*....|..
gi 672046998    246 DVDECqAIPGLCQ-GGNCINTVGSFECKCPAG 276
Cdd:smart00179    1 DIDEC-ASGNPCQnGGTCVNTVGSYRCECPPG 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
491-522 7.06e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.46  E-value: 7.06e-03
                            10        20        30
                    ....*....|....*....|....*....|....
gi 672046998    491 DVDECE-KNPC-TGGECINNQGSYTCHCRAGYQS 522
Cdd:smart00179    1 DIDECAsGNPCqNGGTCVNTVGSYRCECPPGYTD 34
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 2014-2055 7.82e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.46  E-value: 7.82e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 672046998 2014 DIDECVEEPEICALGTCSNTEGSFKCLCPEGFslssTGRRCQ 2055
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGY----TGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 2525-2560 7.90e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.46  E-value: 7.90e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 672046998 2525 DNNECTSEiNLCGSKGVCQNTPGSFTCECQRGFSLD 2560
Cdd:cd00054     1 DIDECASG-NPCQNGGTCVNTVGSYRCSCPPGYTGR 35
EGF_CA pfam07645
Calcium-binding EGF domain;
911-941 9.08e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.06  E-value: 9.08e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 672046998   911 DINECEVFPGVC-KNGLCVNSRGSFKCECPSG 941
Cdd:pfam07645    1 DVDECATGTHNCpANTVCVNTIGSFECRCPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 288-320 9.25e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.08  E-value: 9.25e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 672046998  288 DIDECSTIPGVCDGGECTNTVSSYFCKCPPGFY 320
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYT 33
EGF_CA pfam07645
Calcium-binding EGF domain;
1607-1637 9.72e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.06  E-value: 9.72e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 672046998  1607 DIDECQELPGLC-QGGKCINTFGSFQCRCPTG 1637
Cdd:pfam07645    1 DVDECATGTHNCpANTVCVNTIGSFECRCPDG 32
 
Name Accession Description Interval E-value
Fibrillin_U_N pfam18193
Fibrillin 1 unique N-terminal domain; This is the N-terminal domain of human fibrillin-1. ...
 48-82 3.22e-12

Fibrillin 1 unique N-terminal domain; This is the N-terminal domain of human fibrillin-1. Fibrillin is a primary constituent of microfibrils in the extracellular matrix of many elastic and non-elastic connective tissues. This domain, known as the fibrillin unique N-terminal (FUN) domain, constitutes the minimal interaction site for the fibrillin C terminus. The FUN domain has homologs in the human proteins LTBP-1L/2 and VWCE, which are also associated with a C-terminal EGF-like domain.


Pssm-ID: 436338  Cd Length: 37  Bit Score: 62.99  E-value: 3.22e-12
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 672046998    48 GGHDALKGPNVCGSRYNAYCCPGWKTLPGGNQCIV 82
Cdd:pfam18193    3 GGADVLRGPNVCGSRFHAYCCPGWKTLPGGNQCIV 37
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 669-712 3.26e-11

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 60.37  E-value: 3.26e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 672046998   669 GQCVKPLFGAVTKSECCCASTEYAFGEPCQPCPAQNSAEYQALC 712
Cdd:pfam00683    1 GRCSNPLPGNVTKSECCCTSVGRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 2069-2112 8.51e-11

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 59.21  E-value: 8.51e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 672046998  2069 GKCSSPKSRNHSKQECCCALKGEGWGDPCELCPTEPDEAFRQIC 2112
Cdd:pfam00683    1 GRCSNPLPGNVTKSECCCTSVGRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 1550-1590 2.00e-09

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 54.98  E-value: 2.00e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 672046998  1550 CSNEIGVGVSKASCCC-SLGKAWGTPCELCPPVNTSEYKILC 1590
Cdd:pfam00683    3 CSNPLPGNVTKSECCCtSVGRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 1706-1749 2.44e-09

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 54.98  E-value: 2.44e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 672046998  1706 TCDGELLFNMTKKMCCCSYnIGRAWNKPCEQCPIPSTDEFATLC 1749
Cdd:pfam00683    2 RCSNPLPGNVTKSECCCTS-VGRAWGSPCELCPPPGTDEFRELC 44
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 1368-1403 6.84e-09

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 53.37  E-value: 6.84e-09
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 672046998  1368 CSNGTHMCSQHADCKNTMGSYRCLCKDGYTGDGFTC 1403
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGGSFTCTCNDGYTGDGVTC 36
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 343-389 5.53e-08

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 51.12  E-value: 5.53e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 672046998   343 GRCSNQLPQSITKMQCCCD-VGRCWSPGvtvaPEMCPIRSTEDFNKLC 389
Cdd:pfam00683    1 GRCSNPLPGNVTKSECCCTsVGRAWGSP----CELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 2358-2391 8.94e-08

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 50.35  E-value: 8.94e-08
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 672046998  2358 PVTKSECCCD-GGRGWGPHCEICPFEGTVAYKKLC 2391
Cdd:pfam00683   10 NVTKSECCCTsVGRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 967-1009 4.55e-07

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 48.43  E-value: 4.55e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 672046998   967 ECTLPIAGRHRMDACCC-SVGAAWGtEECEECPLRNSREYEELC 1009
Cdd:pfam00683    2 RCSNPLPGNVTKSECCCtSVGRAWG-SPCELCPPPGTDEFRELC 44
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 1327-1362 9.51e-07

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 47.21  E-value: 9.51e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 672046998  1327 CEIGAHNCGRHAVCTNTAGSFKCSCSPGWIGDGIKC 1362
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGGSFTCTCNDGYTGDGVTC 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
1809-1841 3.21e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.09  E-value: 3.21e-06
                            10        20        30
                    ....*....|....*....|....*....|...
gi 672046998   1809 DIDECQNGPVCQRNAECINTAGSYRCDCKPGYR 1841
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1809-1844 3.49e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.71  E-value: 3.49e-06
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 672046998 1809 DIDECQNGPVCQRNAECINTAGSYRCDCKPGYRLTS 1844
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGRN 36
EGF_CA pfam07645
Calcium-binding EGF domain;
1323-1354 4.24e-06

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 45.31  E-value: 4.24e-06
                           10        20        30
                   ....*....|....*....|....*....|..
gi 672046998  1323 DINECEIGAHNCGRHAVCTNTAGSFKCSCSPG 1354
Cdd:pfam07645    1 DVDECATGTHNCPANTVCVNTIGSFECRCPDG 32
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 1202-1237 4.35e-06

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 45.31  E-value: 4.35e-06
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 672046998  1202 CSIMNGGCETFCTNSDGSYECSCQPGFALMPDQRSC 1237
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 1195-1236 5.53e-06

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 50.08  E-value: 5.53e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 672046998 1195 FCVDIDECSIMNGGCETFCTNSDGSYECSCQPGFALMPDQRS 1236
Cdd:cd01475   183 ICVVPDLCATLSHVCQQVCISTPGSYLCACTEGYALLEDNKT 224
EGF_CA smart00179
Calcium-binding EGF-like domain;
531-572 2.05e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.77  E-value: 2.05e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 672046998    531 DIDECLQNGRICNNGRCINTDGSFHCVCNAGFHvtrDGKNCE 572
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA pfam07645
Calcium-binding EGF domain;
1364-1395 3.93e-05

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 42.61  E-value: 3.93e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 672046998  1364 DLDECSNGTHMCSQHADCKNTMGSYRCLCKDG 1395
Cdd:pfam07645    1 DVDECATGTHNCPANTVCVNTIGSFECRCPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 531-572 7.11e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.24  E-value: 7.11e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 672046998  531 DIDECLQNGRICNNGRCINTDGSFHCVCNAGFHvtrdGKNCE 572
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYT----GRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
614-647 7.22e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.23  E-value: 7.22e-05
                            10        20        30
                    ....*....|....*....|....*....|....*
gi 672046998    614 DINECETPGICMNG-RCVNTDGSYRCECFPGLAVG 647
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYTDG 35
EGF_CA smart00179
Calcium-binding EGF-like domain;
1931-1973 9.14e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.85  E-value: 9.14e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 672046998   1931 DVDECATGNgnLCRNG-QCVNTVGSFQCRCNEGYEvapDGRTCV 1973
Cdd:smart00179    1 DIDECASGN--PCQNGgTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA pfam07645
Calcium-binding EGF domain;
2486-2515 1.12e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 41.45  E-value: 1.12e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 672046998  2486 DLDECATKQHNCQ--FLCVNTIGGFTCKCPPG 2515
Cdd:pfam07645    1 DVDECATGTHNCPanTVCVNTIGSFECRCPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
2128-2166 1.51e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.08  E-value: 1.51e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 672046998   2128 DMDECKEPDVCKHG-QCINTDGSYRCECPFGYIlEGNECV 2166
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT-DGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
2167-2206 1.68e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.08  E-value: 1.68e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 672046998   2167 DTDECSVGNPCGNG-TCKNVIGGFECTCEEGFEPGpmMTCE 2206
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYTDG--RNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
2608-2639 1.93e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.08  E-value: 1.93e-04
                            10        20        30
                    ....*....|....*....|....*....|...
gi 672046998   2608 DENECLSAHVCG-GASCHNTLGSYKCMCPAGFQ 2639
Cdd:smart00179    1 DIDECASGNPCQnGGTCVNTVGSYRCECPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
2568-2597 2.35e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.69  E-value: 2.35e-04
                            10        20        30
                    ....*....|....*....|....*....|..
gi 672046998   2568 DVDECEGNHRCQHG--CQNIIGGYRCSCPQGY 2597
Cdd:smart00179    1 DIDECASGNPCQNGgtCVNTVGSYRCECPPGY 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 614-643 3.04e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.31  E-value: 3.04e-04
                          10        20        30
                  ....*....|....*....|....*....|.
gi 672046998  614 DINECETPGICMN-GRCVNTDGSYRCECFPG 643
Cdd:cd00054     1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPG 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
1364-1404 3.38e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.31  E-value: 3.38e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 672046998   1364 DLDECSNGtHMCSQHADCKNTMGSYRCLCKDGYTgDGFTCT 1404
Cdd:smart00179    1 DIDECASG-NPCQNGGTCVNTVGSYRCECPPGYT-DGRNCE 39
EGF_CA pfam07645
Calcium-binding EGF domain;
1931-1962 3.47e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 39.91  E-value: 3.47e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 672046998  1931 DVDECATGNGNLCRNGQCVNTVGSFQCRCNEG 1962
Cdd:pfam07645    1 DVDECATGTHNCPANTVCVNTIGSFECRCPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 2128-2160 3.74e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.93  E-value: 3.74e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 672046998 2128 DMDECKEPDVCK-HGQCINTDGSYRCECPFGYIL 2160
Cdd:cd00054     1 DIDECASGNPCQnGGTCVNTVGSYRCSCPPGYTG 34
EGF_CA smart00179
Calcium-binding EGF-like domain;
573-613 3.84e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.92  E-value: 3.84e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 672046998    573 DMDECSIRNMCLNG-MCINEDGSFKCICKPGFQlasDGRYCK 613
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA pfam07645
Calcium-binding EGF domain;
1809-1839 4.10e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 39.91  E-value: 4.10e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 672046998  1809 DIDECQNGP-VCQRNAECINTAGSYRCDCKPG 1839
Cdd:pfam07645    1 DVDECATGThNCPANTVCVNTIGSFECRCPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
1649-1688 4.53e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.92  E-value: 4.53e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 672046998   1649 DVNECETPGICGPG-TCYNTVGNYTCICPPDYMQvngGNNC 1688
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYTD---GRNC 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1323-1358 4.92e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.93  E-value: 4.92e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 672046998 1323 DINECEIGaHNCGRHAVCTNTAGSFKCSCSPGWIGD 1358
Cdd:cd00054     1 DIDECASG-NPCQNGGTCVNTVGSYRCSCPPGYTGR 35
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 861-891 5.56e-04

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 39.95  E-value: 5.56e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 672046998   861 GRCEININGATLKSECC-SSLGAAWGSPCTIC 891
Cdd:pfam00683    1 GRCSNPLPGNVTKSECCcTSVGRAWGSPCELC 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1364-1399 6.88e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.16  E-value: 6.88e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 672046998 1364 DLDECSNGtHMCSQHADCKNTMGSYRCLCKDGYTGD 1399
Cdd:cd00054     1 DIDECASG-NPCQNGGTCVNTVGSYRCSCPPGYTGR 35
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 2443-2483 7.34e-04

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 43.53  E-value: 7.34e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 672046998 2443 CVDLNECNQAPKPCNFICKNTEGSYQCSCPKGYILQEDGRS 2483
Cdd:cd01475   184 CVVPDLCATLSHVCQQVCISTPGSYLCACTEGYALLEDNKT 224
EGF_CA smart00179
Calcium-binding EGF-like domain;
1323-1363 7.94e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.15  E-value: 7.94e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 672046998   1323 DINECEIGaHNCGRHAVCTNTAGSFKCSCSPGWIgDGIKCT 1363
Cdd:smart00179    1 DIDECASG-NPCQNGGTCVNTVGSYRCECPPGYT-DGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
1114-1150 8.76e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.15  E-value: 8.76e-04
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 672046998   1114 DIDECQRDPLLCRGGICHNTEGSYRCECPSGHQLSPN 1150
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYTDGRN 37
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 1926-1971 8.89e-04

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 43.53  E-value: 8.89e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 672046998 1926 NNDCIDVDECATGNGNlCRNGqCVNTVGSFQCRCNEGYEVAPDGRT 1971
Cdd:cd01475   181 GKICVVPDLCATLSHV-CQQV-CISTPGSYLCACTEGYALLEDNKT 224
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 2608-2639 9.06e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.16  E-value: 9.06e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 672046998 2608 DENECLSAHVCG-GASCHNTLGSYKCMCPAGFQ 2639
Cdd:cd00054     1 DIDECASGNPCQnGGTCVNTVGSYRCSCPPGYT 33
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 2449-2484 9.17e-04

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 38.76  E-value: 9.17e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 672046998  2449 CNQAPKPCNFICKNTEGSYQCSCPKGYILQEDGRSC 2484
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
EGF_CA pfam07645
Calcium-binding EGF domain;
2014-2044 9.93e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 38.76  E-value: 9.93e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 672046998  2014 DIDECVEEPEICALGT-CSNTEGSFKCLCPEG 2044
Cdd:pfam07645    1 DVDECATGTHNCPANTvCVNTIGSFECRCPDG 32
EGF_CA pfam07645
Calcium-binding EGF domain;
1767-1797 1.03e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 38.76  E-value: 1.03e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 672046998  1767 DIDECREIPGVC-ENGVCINMVGSFRCECPVG 1797
Cdd:pfam07645    1 DVDECATGTHNCpANTVCVNTIGSFECRCPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 2568-2597 1.19e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.77  E-value: 1.19e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 672046998 2568 DVDECEGNHRCQHG--CQNIIGGYRCSCPQGY 2597
Cdd:cd00054     1 DIDECASGNPCQNGgtCVNTVGSYRCSCPPGY 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
288-329 1.20e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.77  E-value: 1.20e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 672046998    288 DIDECSTIPGVCDGGECTNTVSSYFCKCPPGFYtspDGTRCV 329
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
1607-1639 1.29e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.77  E-value: 1.29e-03
                            10        20        30
                    ....*....|....*....|....*....|...
gi 672046998   1607 DIDECQELPGLCQGGKCINTFGSFQCRCPTGYY 1639
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1931-1973 1.33e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.39  E-value: 1.33e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 672046998 1931 DVDECATGNgnLCRN-GQCVNTVGSFQCRCNEGYEvapdGRTCV 1973
Cdd:cd00054     1 DIDECASGN--PCQNgGTCVNTVGSYRCSCPPGYT----GRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 2167-2198 1.33e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.39  E-value: 1.33e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 672046998 2167 DTDECSVGNPCGN-GTCKNVIGGFECTCEEGFE 2198
Cdd:cd00054     1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
1488-1519 1.43e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.38  E-value: 1.43e-03
                            10        20        30
                    ....*....|....*....|....*....|...
gi 672046998   1488 DVNECLDPTTCISG-NCVNTPGSYTCDCPPDFE 1519
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1114-1147 1.65e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.39  E-value: 1.65e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 672046998 1114 DIDECQRDPLLCRGGICHNTEGSYRCECPSGHQL 1147
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTG 34
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 573-607 1.82e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.00  E-value: 1.82e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 672046998  573 DMDECSIRNMCLN-GMCINEDGSFKCICKPGFQLAS 607
Cdd:cd00054     1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGYTGRN 36
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1488-1520 1.99e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.00  E-value: 1.99e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 672046998 1488 DVNECLDPTTC-ISGNCVNTPGSYTCDCPPDFEL 1520
Cdd:cd00054     1 DIDECASGNPCqNGGTCVNTVGSYRCSCPPGYTG 34
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1974-2009 2.13e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.00  E-value: 2.13e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 672046998 1974 DINECVLDPGKCAPGTCQNLDGSYRCICPPGYSLQN 2009
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGRN 36
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 2481-2517 2.15e-03

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 42.37  E-value: 2.15e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 672046998 2481 GRSCKDLDECATKQHNCQFLCVNTIGGFTCKCPPGFT 2517
Cdd:cd01475   181 GKICVVPDLCATLSHVCQQVCISTPGSYLCACTEGYA 217
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1649-1680 2.15e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.00  E-value: 2.15e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 672046998 1649 DVNECETPGICGP-GTCYNTVGNYTCICPPDYM 1680
Cdd:cd00054     1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
1447-1487 2.46e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.00  E-value: 2.46e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 672046998   1447 DINECSLPNICVFG-TCHNLPGLFRCECEIGYEldrSGGNCT 1487
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
2525-2567 2.59e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.61  E-value: 2.59e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 672046998   2525 DNNECTSEiNLCGSKGVCQNTPGSFTCECQRGFsldQSGASCE 2567
Cdd:smart00179    1 DIDECASG-NPCQNGGTCVNTVGSYRCECPPGY---TDGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
1767-1798 2.66e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.61  E-value: 2.66e-03
                            10        20        30
                    ....*....|....*....|....*....|...
gi 672046998   1767 DIDECrEIPGVCENG-VCINMVGSFRCECPVGF 1798
Cdd:smart00179    1 DIDEC-ASGNPCQNGgTCVNTVGSYRCECPPGY 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
766-797 2.80e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.61  E-value: 2.80e-03
                            10        20        30
                    ....*....|....*....|....*....|..
gi 672046998    766 DINECVLNSLLCDNGQCRNTPGSFVCTCPKGF 797
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGY 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 766-807 2.89e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.62  E-value: 2.89e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 672046998  766 DINECVLNSLLCDNGQCRNTPGSFVCTCPKGFVykpdLKTCE 807
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYT----GRNCE 38
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 194-227 2.94e-03

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 37.64  E-value: 2.94e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 672046998   194 MCQGQLSGIVCTKTLCCATVGRAWGHPCEMCPAQ 227
Cdd:pfam00683    2 RCSNPLPGNVTKSECCCTSVGRAWGSPCELCPPP 35
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1447-1481 3.59e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.23  E-value: 3.59e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 672046998 1447 DINECSLPNICVF-GTCHNLPGLFRCECEIGYELDR 1481
Cdd:cd00054     1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGYTGRN 36
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1607-1640 4.29e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.23  E-value: 4.29e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 672046998 1607 DIDECQELPGLCQGGKCINTFGSFQCRCPTGYYL 1640
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTG 34
EGF_CA smart00179
Calcium-binding EGF-like domain;
1974-2006 4.81e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.84  E-value: 4.81e-03
                            10        20        30
                    ....*....|....*....|....*....|....
gi 672046998   1974 DINECvLDPGKCAPG-TCQNLDGSYRCICPPGYS 2006
Cdd:smart00179    1 DIDEC-ASGNPCQNGgTCVNTVGSYRCECPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
1071-1105 4.81e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.84  E-value: 4.81e-03
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 672046998   1071 DIDECRiSPDLCGRG-QCVNTPGDFECKCDEGYESG 1105
Cdd:smart00179    1 DIDECA-SGNPCQNGgTCVNTVGSYRCECPPGYTDG 35
EGF_CA smart00179
Calcium-binding EGF-like domain;
2014-2055 5.52e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.84  E-value: 5.52e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 672046998   2014 DIDECVEEPEICALGTCSNTEGSFKCLCPEGFslsSTGRRCQ 2055
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGY---TDGRNCE 39
cEGF pfam12662
Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved ...
 1956-1977 5.89e-03

Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved cysteine residues disulfide-bonded into the characteriztic pattern 'ababcc'. They are found in blood coagulation proteins such as fibrillin, Clr and Cls, thrombomodulin, and the LDL receptor. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal cysteine residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In cEGFs the C-terminal thiol resides on the C-terminal beta-sheet, resulting in long loop-lengths between the cysteine residues of disulfide 'c', typically C[10+]XC. These longer loop-lengths may have arisen by selective cysteine loss from a four-disulfide EGF template such as laminin or integrin. Tandem cEGF domains have five linking residues between terminal cysteines of adjacent domains. cEGF domains may or may not bind calcium in the linker region. cEGF domains with the consensus motif CXN4X[F,Y]XCXC are hydroxylated exclusively on the asparagine residue.


Pssm-ID: 463661  Cd Length: 22  Bit Score: 36.23  E-value: 5.89e-03
                           10        20
                   ....*....|....*....|..
gi 672046998  1956 QCRCNEGYEVAPDGRTCVDINE 1977
Cdd:pfam12662    1 TCSCPPGYQLDPDGRTCVDIDE 22
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1767-1798 6.30e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.46  E-value: 6.30e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 672046998 1767 DIDECREIPGVCENGVCINMVGSFRCECPVGF 1798
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGY 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
246-276 7.00e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.46  E-value: 7.00e-03
                            10        20        30
                    ....*....|....*....|....*....|..
gi 672046998    246 DVDECqAIPGLCQ-GGNCINTVGSFECKCPAG 276
Cdd:smart00179    1 DIDEC-ASGNPCQnGGTCVNTVGSYRCECPPG 31
EGF_CA pfam07645
Calcium-binding EGF domain;
2445-2474 7.03e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.45  E-value: 7.03e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 672046998  2445 DLNECNQAPKPC--NFICKNTEGSYQCSCPKG 2474
Cdd:pfam07645    1 DVDECATGTHNCpaNTVCVNTIGSFECRCPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
491-522 7.06e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.46  E-value: 7.06e-03
                            10        20        30
                    ....*....|....*....|....*....|....
gi 672046998    491 DVDECE-KNPC-TGGECINNQGSYTCHCRAGYQS 522
Cdd:smart00179    1 DIDECAsGNPCqNGGTCVNTVGSYRCECPPGYTD 34
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 2014-2055 7.82e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.46  E-value: 7.82e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 672046998 2014 DIDECVEEPEICALGTCSNTEGSFKCLCPEGFslssTGRRCQ 2055
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGY----TGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 2525-2560 7.90e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.46  E-value: 7.90e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 672046998 2525 DNNECTSEiNLCGSKGVCQNTPGSFTCECQRGFSLD 2560
Cdd:cd00054     1 DIDECASG-NPCQNGGTCVNTVGSYRCSCPPGYTGR 35
EGF_CA pfam07645
Calcium-binding EGF domain;
911-941 9.08e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.06  E-value: 9.08e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 672046998   911 DINECEVFPGVC-KNGLCVNSRGSFKCECPSG 941
Cdd:pfam07645    1 DVDECATGTHNCpANTVCVNTIGSFECRCPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 288-320 9.25e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.08  E-value: 9.25e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 672046998  288 DIDECSTIPGVCDGGECTNTVSSYFCKCPPGFY 320
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYT 33
EGF_CA pfam07645
Calcium-binding EGF domain;
1607-1637 9.72e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.06  E-value: 9.72e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 672046998  1607 DIDECQELPGLC-QGGKCINTFGSFQCRCPTG 1637
Cdd:pfam07645    1 DVDECATGTHNCpANTVCVNTIGSFECRCPDG 32
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 1935-1972 9.73e-03

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 36.04  E-value: 9.73e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 672046998  1935 CATGNGNLCRNGQCVNTVGSFQCRCNEGYEvaPDGRTC 1972
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGGSFTCTCNDGYT--GDGVTC 36
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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