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Conserved domains on  [gi|672055020|ref|XP_008762599|]
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espin isoform X3 [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
52-324 1.84e-41

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 153.96  E-value: 1.84e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672055020  52 LRYLVEEVALPAVSRARNGATPAHDAAATGYLSCLQWLLTQGGCRVQEKDNSGATVLHLAARFGHPDVVNWLLYQGGANS 131
Cdd:COG0666    1 LLLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672055020 132 AITTDTGALPIHYAAAKGDLPSMKLLVGHYPEgVNAQTNNGATPLYLACQEGHLEVTKYLVqECSADPHLRAQDGMTPLH 211
Cdd:COG0666   81 NAKDDGGNTLLHAAARNGDLEIVKLLLEAGAD-VNARDKDGETPLHLAAYNGNLEIVKLLL-EAGADVNAQDNDGNTPLH 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672055020 212 AAAQMGHNPVLVWLVSF-ADVSfsEQDHDGATAMHFAASRGHTKVLSWLLLHGAEIS-QDLWGGTPLHDAAENGELECCQ 289
Cdd:COG0666  159 LAAANGNLEIVKLLLEAgADVN--ARDNDGETPLHLAAENGHLEIVKLLLEAGADVNaKDNDGKTALDLAAENGNLEIVK 236

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 672055020 290 ILAVNGAGLDVRDHDGYTAADLADFNGHTHCSRYL 324
Cdd:COG0666  237 LLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLL 271
WH2 pfam02205
WH2 motif; The WH2 motif (for Wiskott Aldrich syndrome homology region 2) has been shown in ...
 666-691 6.48e-03

WH2 motif; The WH2 motif (for Wiskott Aldrich syndrome homology region 2) has been shown in WASP and Scar1 (mammalian homolog) to be the region that interacts with actin.


:

Pssm-ID: 460490  Cd Length: 28  Bit Score: 34.78  E-value: 6.48e-03
                          10        20
                  ....*....|....*....|....*.
gi 672055020  666 PTGDNSELLAEIKAGKSLKPTPQSKG 691
Cdd:pfam02205   1 GGGGRGALLADIRAGKKLKKVEETND 26
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
52-324 1.84e-41

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 153.96  E-value: 1.84e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672055020  52 LRYLVEEVALPAVSRARNGATPAHDAAATGYLSCLQWLLTQGGCRVQEKDNSGATVLHLAARFGHPDVVNWLLYQGGANS 131
Cdd:COG0666    1 LLLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672055020 132 AITTDTGALPIHYAAAKGDLPSMKLLVGHYPEgVNAQTNNGATPLYLACQEGHLEVTKYLVqECSADPHLRAQDGMTPLH 211
Cdd:COG0666   81 NAKDDGGNTLLHAAARNGDLEIVKLLLEAGAD-VNARDKDGETPLHLAAYNGNLEIVKLLL-EAGADVNAQDNDGNTPLH 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672055020 212 AAAQMGHNPVLVWLVSF-ADVSfsEQDHDGATAMHFAASRGHTKVLSWLLLHGAEIS-QDLWGGTPLHDAAENGELECCQ 289
Cdd:COG0666  159 LAAANGNLEIVKLLLEAgADVN--ARDNDGETPLHLAAENGHLEIVKLLLEAGADVNaKDNDGKTALDLAAENGNLEIVK 236

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 672055020 290 ILAVNGAGLDVRDHDGYTAADLADFNGHTHCSRYL 324
Cdd:COG0666  237 LLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLL 271
Ank_2 pfam12796
Ankyrin repeats (3 copies);
176-266 1.68e-20

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 86.71  E-value: 1.68e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672055020  176 LYLACQEGHLEVTKYLVqECSADPHLRAQDGMTPLHAAAQMGHNPVLVWLVSFADVsfsEQDHDGATAMHFAASRGHTKV 255
Cdd:pfam12796   1 LHLAAKNGNLELVKLLL-ENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADV---NLKDNGRTALHYAARSGHLEI 76

                          90
                  ....*....|.
gi 672055020  256 LSWLLLHGAEI 266
Cdd:pfam12796  77 VKLLLEKGADI 87
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 94-279 4.07e-14

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 75.39  E-value: 4.07e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672055020  94 GCRVQEKDNSGATVLHLAARFGHPDVVNwLLYQGGANSAITTDTGALPIHYAAAKGDLPSMKLLV--GHYpegVNAQTNN 171
Cdd:PHA02874 114 GIDVNIKDAELKTFLHYAIKKGDLESIK-MLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLekGAY---ANVKDNN 189

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672055020 172 GATPLYLACQEGHLEVTKYLVQECSaDPHLRAQDGMTPLHAAaqMGHNPVLVWLVsFADVSFSEQDHDGATAMHFAASRG 251
Cdd:PHA02874 190 GESPLHNAAEYGDYACIKLLIDHGN-HIMNKCKNGFTPLHNA--IIHNRSAIELL-INNASINDQDIDGSTPLHHAINPP 265

                        170       180       190
                 ....*....|....*....|....*....|
gi 672055020 252 HTK-VLSWLLLHGAEIS-QDLWGGTPLHDA 279
Cdd:PHA02874 266 CDIdIIDILLYHKADISiKDNKGENPIDTA 295
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 140-312 1.67e-07

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 55.02  E-value: 1.67e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672055020 140 LPIHYAAAKGDLPSMKLLVGHYPEGVNAQTNNGATPLYLACQEGHLEVTKYLV--------QECSADPHLraqdGMTPLH 211
Cdd:cd22192   19 SPLLLAAKENDVQAIKKLLKCPSCDLFQRGALGETALHVAALYDNLEAAVVLMeaapelvnEPMTSDLYQ----GETALH 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672055020 212 AAAqMGHNPVLVWLV--SFADVS--------FSEQDHD----GATAMHFAASRGHTKVLSWLLLHGAEI-SQDLWGGTPL 276
Cdd:cd22192   95 IAV-VNQNLNLVRELiaRGADVVspratgtfFRPGPKNliyyGEHPLSFAACVGNEEIVRLLIEHGADIrAQDSLGNTVL 173

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 672055020 277 HD-AAENGELECCQ----ILAV----NGAGLD-VRDHDGYTAADLA 312
Cdd:cd22192  174 HIlVLQPNKTFACQmydlILSYdkedDLQPLDlVPNNQGLTPFKLA 219
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 171-201 8.74e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 37.57  E-value: 8.74e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 672055020   171 NGATPLYLACQEGHLEVTKYLVQEcSADPHL 201
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDK-GADINA 30
WH2 pfam02205
WH2 motif; The WH2 motif (for Wiskott Aldrich syndrome homology region 2) has been shown in ...
 666-691 6.48e-03

WH2 motif; The WH2 motif (for Wiskott Aldrich syndrome homology region 2) has been shown in WASP and Scar1 (mammalian homolog) to be the region that interacts with actin.


Pssm-ID: 460490  Cd Length: 28  Bit Score: 34.78  E-value: 6.48e-03
                          10        20
                  ....*....|....*....|....*.
gi 672055020  666 PTGDNSELLAEIKAGKSLKPTPQSKG 691
Cdd:pfam02205   1 GGGGRGALLADIRAGKKLKKVEETND 26
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
52-324 1.84e-41

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 153.96  E-value: 1.84e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672055020  52 LRYLVEEVALPAVSRARNGATPAHDAAATGYLSCLQWLLTQGGCRVQEKDNSGATVLHLAARFGHPDVVNWLLYQGGANS 131
Cdd:COG0666    1 LLLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672055020 132 AITTDTGALPIHYAAAKGDLPSMKLLVGHYPEgVNAQTNNGATPLYLACQEGHLEVTKYLVqECSADPHLRAQDGMTPLH 211
Cdd:COG0666   81 NAKDDGGNTLLHAAARNGDLEIVKLLLEAGAD-VNARDKDGETPLHLAAYNGNLEIVKLLL-EAGADVNAQDNDGNTPLH 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672055020 212 AAAQMGHNPVLVWLVSF-ADVSfsEQDHDGATAMHFAASRGHTKVLSWLLLHGAEIS-QDLWGGTPLHDAAENGELECCQ 289
Cdd:COG0666  159 LAAANGNLEIVKLLLEAgADVN--ARDNDGETPLHLAAENGHLEIVKLLLEAGADVNaKDNDGKTALDLAAENGNLEIVK 236

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 672055020 290 ILAVNGAGLDVRDHDGYTAADLADFNGHTHCSRYL 324
Cdd:COG0666  237 LLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLL 271
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
33-309 7.52e-41

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 152.03  E-value: 7.52e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672055020  33 DPLDALPVHHAARSGKLHCLRYLVEEVALPAVSRARNGATPAHDAAATGYLSCLQWLLTQGGCRVQEKDNSGATVLHLAA 112
Cdd:COG0666   16 LLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAA 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672055020 113 RFGHPDVVNWLLyQGGANSAITTDTGALPIHYAAAKGDLPSMKLLVGHypeG--VNAQTNNGATPLYLACQEGHLEVTKY 190
Cdd:COG0666   96 RNGDLEIVKLLL-EAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEA---GadVNAQDNDGNTPLHLAAANGNLEIVKL 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672055020 191 LVqECSADPHLRAQDGMTPLHAAAQMGHNPVLVWLVSF-ADVSFseQDHDGATAMHFAASRGHTKVLSWLLLHGAEIS-Q 268
Cdd:COG0666  172 LL-EAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAgADVNA--KDNDGKTALDLAAENGNLEIVKLLLEAGADLNaK 248

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 672055020 269 DLWGGTPLHDAAENGELECCQILAVNGAGLDVRDHDGYTAA 309
Cdd:COG0666  249 DKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
2-277 8.66e-39

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 146.25  E-value: 8.66e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672055020   2 ALEQAMQAARRGDLDVLRSLHAAGLLGPSLRDPLDALPVHHAARSGKLHCLRYLVEEVALPAVsRARNGATPAHDAAATG 81
Cdd:COG0666   20 LLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINA-KDDGGNTLLHAAARNG 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672055020  82 YLSCLQWLLTQGGcRVQEKDNSGATVLHLAARFGHPDVVNWLLyQGGANSAITTDTGALPIHYAAAKGDLPSMKLLVGHY 161
Cdd:COG0666   99 DLEIVKLLLEAGA-DVNARDKDGETPLHLAAYNGNLEIVKLLL-EAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAG 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672055020 162 PEgVNAQTNNGATPLYLACQEGHLEVTKYLVqECSADPHLRAQDGMTPLHAAAQMGHNPVLVWLVSFADVSfSEQDHDGA 241
Cdd:COG0666  177 AD-VNARDNDGETPLHLAAENGHLEIVKLLL-EAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADL-NAKDKDGL 253

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 672055020 242 TAMHFAASRGHTKVLSWLLLHGAEISQDLWGGTPLH 277
Cdd:COG0666  254 TALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
101-325 2.22e-37

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 142.02  E-value: 2.22e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672055020 101 DNSGATVLHLAARFGHPDVVNWLLYQGGANSAITTDTGALPIHYAAAKGDLPSMKLLVGHYPEGVNAQTNNGATPLYLAC 180
Cdd:COG0666   16 LLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAA 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672055020 181 QEGHLEVTKYLVqECSADPHLRAQDGMTPLHAAAQMGHNPVLVWLVSF-ADVSfsEQDHDGATAMHFAASRGHTKVLSWL 259
Cdd:COG0666   96 RNGDLEIVKLLL-EAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAgADVN--AQDNDGNTPLHLAAANGNLEIVKLL 172

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 672055020 260 LLHGAEI-SQDLWGGTPLHDAAENGELECCQILAVNGAGLDVRDHDGYTAADLADFNGHTHCSRYLR 325
Cdd:COG0666  173 LEAGADVnARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLL 239
Ank_2 pfam12796
Ankyrin repeats (3 copies);
176-266 1.68e-20

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 86.71  E-value: 1.68e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672055020  176 LYLACQEGHLEVTKYLVqECSADPHLRAQDGMTPLHAAAQMGHNPVLVWLVSFADVsfsEQDHDGATAMHFAASRGHTKV 255
Cdd:pfam12796   1 LHLAAKNGNLELVKLLL-ENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADV---NLKDNGRTALHYAARSGHLEI 76

                          90
                  ....*....|.
gi 672055020  256 LSWLLLHGAEI 266
Cdd:pfam12796  77 VKLLLEKGADI 87
Ank_2 pfam12796
Ankyrin repeats (3 copies);
210-302 1.94e-18

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 80.93  E-value: 1.94e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672055020  210 LHAAAQMGHNPVLVWLVSfADVSFSEQDHDGATAMHFAASRGHTKVLSWLLLHgAEISQDLWGGTPLHDAAENGELECCQ 289
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLE-NGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDNGRTALHYAARSGHLEIVK 78

                          90
                  ....*....|...
gi 672055020  290 ILAVNGAGLDVRD 302
Cdd:pfam12796  79 LLLEKGADINVKD 91
Ank_2 pfam12796
Ankyrin repeats (3 copies);
108-202 1.42e-17

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 78.23  E-value: 1.42e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672055020  108 LHLAARFGHPDVVNWLLyQGGANSAITTDTGALPIHYAAAKGDLPSMKLLVGHypEGVNAQtNNGATPLYLACQEGHLEV 187
Cdd:pfam12796   1 LHLAAKNGNLELVKLLL-ENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH--ADVNLK-DNGRTALHYAARSGHLEI 76

                          90
                  ....*....|....*
gi 672055020  188 TKYLVqECSADPHLR 202
Cdd:pfam12796  77 VKLLL-EKGADINVK 90
Ank_2 pfam12796
Ankyrin repeats (3 copies);
142-227 1.45e-17

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 78.23  E-value: 1.45e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672055020  142 IHYAAAKGDLPSMKLLVgHYPEGVNAQTNNGATPLYLACQEGHLEVTKYLVQECSADphlRAQDGMTPLHAAAQMGHNPV 221
Cdd:pfam12796   1 LHLAAKNGNLELVKLLL-ENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVN---LKDNGRTALHYAARSGHLEI 76


                  ....*.
gi 672055020  222 LVWLVS 227
Cdd:pfam12796  77 VKLLLE 82
Ank_2 pfam12796
Ankyrin repeats (3 copies);
41-127 1.28e-14

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 70.14  E-value: 1.28e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672055020   41 HHAARSGKLHCLRYLVEEVALPAVSRArNGATPAHDAAATGYLSCLQWLLTQGGCRVQekdNSGATVLHLAARFGHPDVV 120
Cdd:pfam12796   2 HLAAKNGNLELVKLLLENGADANLQDK-NGRTALHLAAKNGHLEIVKLLLEHADVNLK---DNGRTALHYAARSGHLEIV 77


                  ....*..
gi 672055020  121 NWLLYQG 127
Cdd:pfam12796  78 KLLLEKG 84
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 94-279 4.07e-14

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 75.39  E-value: 4.07e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672055020  94 GCRVQEKDNSGATVLHLAARFGHPDVVNwLLYQGGANSAITTDTGALPIHYAAAKGDLPSMKLLV--GHYpegVNAQTNN 171
Cdd:PHA02874 114 GIDVNIKDAELKTFLHYAIKKGDLESIK-MLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLekGAY---ANVKDNN 189

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672055020 172 GATPLYLACQEGHLEVTKYLVQECSaDPHLRAQDGMTPLHAAaqMGHNPVLVWLVsFADVSFSEQDHDGATAMHFAASRG 251
Cdd:PHA02874 190 GESPLHNAAEYGDYACIKLLIDHGN-HIMNKCKNGFTPLHNA--IIHNRSAIELL-INNASINDQDIDGSTPLHHAINPP 265

                        170       180       190
                 ....*....|....*....|....*....|
gi 672055020 252 HTK-VLSWLLLHGAEIS-QDLWGGTPLHDA 279
Cdd:PHA02874 266 CDIdIIDILLYHKADISiKDNKGENPIDTA 295
Ank_2 pfam12796
Ankyrin repeats (3 copies);
75-168 5.24e-14

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 68.22  E-value: 5.24e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672055020   75 HDAAATGYLSCLQWLLtQGGCRVQEKDNSGATVLHLAARFGHPDVVNWLLYQGGANSaitTDTGALPIHYAAAKGDLPSM 154
Cdd:pfam12796   2 HLAAKNGNLELVKLLL-ENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNL---KDNGRTALHYAARSGHLEIV 77

                          90
                  ....*....|....
gi 672055020  155 KLLVGHYPEgVNAQ 168
Cdd:pfam12796  78 KLLLEKGAD-INVK 90
Ank_2 pfam12796
Ankyrin repeats (3 copies);
7-101 1.59e-13

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 67.06  E-value: 1.59e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672055020    7 MQAARRGDLDVLRSLHAAGLlGPSLRDPLDALPVHHAARSGKLHCLRYLVEEValpAVSRARNGATPAHDAAATGYLSCL 86
Cdd:pfam12796   2 HLAAKNGNLELVKLLLENGA-DANLQDKNGRTALHLAAKNGHLEIVKLLLEHA---DVNLKDNGRTALHYAARSGHLEIV 77

                          90
                  ....*....|....*
gi 672055020   87 QWLLTQgGCRVQEKD 101
Cdd:pfam12796  78 KLLLEK-GADINVKD 91
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 88-214 6.85e-12

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 68.54  E-value: 6.85e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672055020  88 WLLTQGGCRVQEKDNSGATVLHLAA--RFGHPDVVNWLLyQGGANSAITTDTGALPIHYAAA--KGDLPSMKLLVGH--- 160
Cdd:PHA03100  90 KLLLEYGANVNAPDNNGITPLLYAIskKSNSYSIVEYLL-DNGANVNIKNSDGENLLHLYLEsnKIDLKILKLLIDKgvd 168

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 672055020 161 ------------YPEGVNAQTNNGATPLYLACQEGHLEVTKYLVqECSADPHLRAQDGMTPLHAAA 214
Cdd:PHA03100 169 inaknrvnyllsYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLL-DLGANPNLVNKYGDTPLHIAI 233
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 198-324 1.15e-11

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 68.74  E-value: 1.15e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672055020 198 DPHLRAQDGMTPLHAAAQMGHNP-VLVWLVSFADVSFseQDHDGATAMHFAASRGHTKVLsWLLLHGAEISQDLWGGTPL 276
Cdd:PLN03192 550 DPDIGDSKGRTPLHIAASKGYEDcVLVLLKHACNVHI--RDANGNTALWNAISAKHHKIF-RILYHFASISDPHAAGDLL 626

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 672055020 277 HDAAENGELECCQILAVNGAGLDVRDHDGYTAADLADFNGHTHCSRYL 324
Cdd:PLN03192 627 CTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLL 674
Ank_4 pfam13637
Ankyrin repeats (many copies);
206-260 1.32e-11

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 60.37  E-value: 1.32e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 672055020  206 GMTPLHAAAQMGHNPVLVWLVSFaDVSFSEQDHDGATAMHFAASRGHTKVLSWLL 260
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEK-GADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA03095 PHA03095
ankyrin-like protein; Provisional
 89-345 2.70e-11

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 66.97  E-value: 2.70e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672055020  89 LLTQGGcRVQEKDNSGATVLHLAARFGHP---DVVNWLLyQGGANSAITTDTGALPIH-YAAAKGDLPSMKLLVGHypeG 164
Cdd:PHA03095  33 LLAAGA-DVNFRGEYGKTPLHLYLHYSSEkvkDIVRLLL-EAGADVNAPERCGFTPLHlYLYNATTLDVIKLLIKA---G 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672055020 165 --VNAQTNNGATPL--YLACQEGHLEVTKYLVQEcSADPHLRAQDGMTPLHA-----------------------AAQMG 217
Cdd:PHA03095 108 adVNAKDKVGRTPLhvYLSGFNINPKVIRLLLRK-GADVNALDLYGMTPLAVllksrnanvellrllidagadvyAVDDR 186

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672055020 218 HNPVL-VWLVSF------------ADVSFSEQDHDGATAMHFAASRGHTK--VLSWLLLHGAEI-SQDLWGGTPLHDAAE 281
Cdd:PHA03095 187 FRSLLhHHLQSFkprarivrelirAGCDPAATDMLGNTPLHSMATGSSCKrsLVLPLLIAGISInARNRYGQTPLHYAAV 266

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 672055020 282 NGELECCQILAVNGAGLDVRDHDGYTAADLADFNGHTHCSRylrtvqtlslehRVLSRDPSMDL 345
Cdd:PHA03095 267 FNNPRACRRLIALGADINAVSSDGNTPLSLMVRNNNGRAVR------------AALAKNPSAET 318
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 2-210 3.65e-10

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 63.73  E-value: 3.65e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672055020   2 ALEQAMQAARRGDLDVLRS----------LHAAGLLGPSLR---DPLDALPVHHAARSGKLHCLRYLVEEVALPAVSRAR 68
Cdd:PLN03192 478 TLIEAMQTRQEDNVVILKNflqhhkelhdLNVGDLLGDNGGehdDPNMASNLLTVASTGNAALLEELLKAKLDPDIGDSK 557

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672055020  69 nGATPAHDAAATGYLSCLQWLLTQGgCRVQEKDNSGATVLHLAARFGHPDVVnWLLYQGGANSaiTTDTGALPIHYAAAK 148
Cdd:PLN03192 558 -GRTPLHIAASKGYEDCVLVLLKHA-CNVHIRDANGNTALWNAISAKHHKIF-RILYHFASIS--DPHAAGDLLCTAAKR 632

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 672055020 149 GDLPSMKLLVGHypeGVNAQTNN--GATPLYLACQEGHLEVTKYLVQECSADPHLRAQDGMTPL 210
Cdd:PLN03192 633 NDLTAMKELLKQ---GLNVDSEDhqGATALQVAMAEDHVDMVRLLIMNGADVDKANTDDDFSPT 693
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 111-309 1.09e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 61.55  E-value: 1.09e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672055020 111 AARFGHPDVVNWLLyQGGANSAITTDTGALPIHYAAAKGDLPSMKLLVGH--YPegvNAQTNNGATPLYLACQEGHLEVT 188
Cdd:PHA02875   9 AILFGELDIARRLL-DIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHgaIP---DVKYPDIESELHDAVEEGDVKAV 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672055020 189 KYLVQECSADPHLRAQDGMTPLHAAAQMGHNPVLVWLVSF-ADVSFSEQDHdgATAMHFAASRGHTKVLSWLLLHGAEIS 267
Cdd:PHA02875  85 EELLDLGKFADDVFYKDGMTPLHLATILKKLDIMKLLIARgADPDIPNTDK--FSPLHLAVMMGDIKGIELLIDHKACLD 162

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 672055020 268 -QDLWGGTPLHDAAENGELECCQILAVNGAGLDVRDHDGYTAA 309
Cdd:PHA02875 163 iEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDYFGKNGCVAA 205
Ank_4 pfam13637
Ankyrin repeats (many copies);
72-124 1.48e-09

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 54.20  E-value: 1.48e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 672055020   72 TPAHDAAATGYLSCLQWLLtQGGCRVQEKDNSGATVLHLAARFGHPDVVNWLL 124
Cdd:pfam13637   3 TALHAAAASGHLELLRLLL-EKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 123-279 3.80e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 60.46  E-value: 3.80e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672055020 123 LLYQGGANSAITTDTGALPIHYAAAKgdlPSMKLLVGHYPE---GVNAQTNNGATPLYLACQEGH-LEVTKYLVQEcSAD 198
Cdd:PHA02876 258 LLYDAGFSVNSIDDCKNTPLHHASQA---PSLSRLVPKLLErgaDVNAKNIKGETPLYLMAKNGYdTENIRTLIML-GAD 333

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672055020 199 phLRAQDGM--TPLHAAAQMGHNPVLVWLVSFADVSFSEQDHDGATAMHFAASRGHTKVLSWLLLHGAEI---SQDLwgG 273
Cdd:PHA02876 334 --VNAADRLyiTPLHQASTLDRNKDIVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGADIealSQKI--G 409


                 ....*.
gi 672055020 274 TPLHDA 279
Cdd:PHA02876 410 TALHFA 415
Ank_4 pfam13637
Ankyrin repeats (many copies);
141-192 5.89e-09

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 52.66  E-value: 5.89e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 672055020  141 PIHYAAAKGDLPSMKLLVGHYPEgVNAQTNNGATPLYLACQEGHLEVTKYLV 192
Cdd:pfam13637   4 ALHAAAASGHLELLRLLLEKGAD-INAVDGNGETALHFAASNGNVEVLKLLL 54
Ank_4 pfam13637
Ankyrin repeats (many copies);
242-291 7.45e-09

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 52.28  E-value: 7.45e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 672055020  242 TAMHFAASRGHTKVLSWLLLHGAEIS-QDLWGGTPLHDAAENGELECCQIL 291
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINaVDGNGETALHFAASNGNVEVLKLL 53
Ank_4 pfam13637
Ankyrin repeats (many copies);
174-226 7.02e-08

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 49.58  E-value: 7.02e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 672055020  174 TPLYLACQEGHLEVTKYLVQEcSADPHLRAQDGMTPLHAAAQMGHNPVLVWLV 226
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEK-GADINAVDGNGETALHFAASNGNVEVLKLLL 54
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 140-312 1.67e-07

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 55.02  E-value: 1.67e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672055020 140 LPIHYAAAKGDLPSMKLLVGHYPEGVNAQTNNGATPLYLACQEGHLEVTKYLV--------QECSADPHLraqdGMTPLH 211
Cdd:cd22192   19 SPLLLAAKENDVQAIKKLLKCPSCDLFQRGALGETALHVAALYDNLEAAVVLMeaapelvnEPMTSDLYQ----GETALH 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672055020 212 AAAqMGHNPVLVWLV--SFADVS--------FSEQDHD----GATAMHFAASRGHTKVLSWLLLHGAEI-SQDLWGGTPL 276
Cdd:cd22192   95 IAV-VNQNLNLVRELiaRGADVVspratgtfFRPGPKNliyyGEHPLSFAACVGNEEIVRLLIEHGADIrAQDSLGNTVL 173

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 672055020 277 HD-AAENGELECCQ----ILAV----NGAGLD-VRDHDGYTAADLA 312
Cdd:cd22192  174 HIlVLQPNKTFACQmydlILSYdkedDLQPLDlVPNNQGLTPFKLA 219
Ank_2 pfam12796
Ankyrin repeats (3 copies);
276-324 2.05e-07

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 49.34  E-value: 2.05e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 672055020  276 LHDAAENGELECCQILAVNGAGLDVRDHDGYTAADLADFNGHTHCSRYL 324
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLL 49
Ank_5 pfam13857
Ankyrin repeats (many copies);
259-312 9.08e-07

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 46.57  E-value: 9.08e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 672055020  259 LLLHGAE--ISQDLWGGTPLHDAAENGELECCQILAVNGAGLDVRDHDGYTAADLA 312
Cdd:pfam13857   1 LLEHGPIdlNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
Ank_4 pfam13637
Ankyrin repeats (many copies);
106-158 1.09e-06

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 46.11  E-value: 1.09e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 672055020  106 TVLHLAARFGHPDVVNWLLyQGGANSAITTDTGALPIHYAAAKGDLPSMKLLV 158
Cdd:pfam13637   3 TALHAAAASGHLELLRLLL-EKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
Ank_4 pfam13637
Ankyrin repeats (many copies);
272-324 1.14e-06

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 46.11  E-value: 1.14e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 672055020  272 GGTPLHDAAENGELECCQILAVNGAGLDVRDHDGYTAADLADFNGHTHCSRYL 324
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLL 53
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 72-260 1.49e-06

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 51.94  E-value: 1.49e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672055020  72 TPAHDAAATGYLSCLQWLLTQGGCRVQEKDNSGATVLHLAARFGHPDVVNWLLYQ--GGANSAITTD--TGALPIHYAAA 147
Cdd:cd22192   19 SPLLLAAKENDVQAIKKLLKCPSCDLFQRGALGETALHVAALYDNLEAAVVLMEAapELVNEPMTSDlyQGETALHIAVV 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672055020 148 KGDLPSMKLLVGHYPEGVNAQTNN-------------GATPL-YLACQeGHLEVTKYLVQEcSADphLRAQD--GMTPLH 211
Cdd:cd22192   99 NQNLNLVRELIARGADVVSPRATGtffrpgpknliyyGEHPLsFAACV-GNEEIVRLLIEH-GAD--IRAQDslGNTVLH 174

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 672055020 212 ---------AAAQMgHNPVLVWLVSFADVSFSE-QDHDGATAMHFAASRGHTKVLSWLL 260
Cdd:cd22192  175 ilvlqpnktFACQM-YDLILSYDKEDDLQPLDLvPNNQGLTPFKLAAKEGNIVMFQHLV 232
Ank_4 pfam13637
Ankyrin repeats (many copies);
39-90 1.82e-06

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 45.73  E-value: 1.82e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 672055020   39 PVHHAARSGKLHCLRYLVEEVALPAVSRaRNGATPAHDAAATGYLSCLQWLL 90
Cdd:pfam13637   4 ALHAAAASGHLELLRLLLEKGADINAVD-GNGETALHFAASNGNVEVLKLLL 54
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 133-307 3.19e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 50.35  E-value: 3.19e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672055020 133 ITTDTGALPIHYAAAKGDLPSMKLLVGHYPEgVNAQTNNGATPLYLACQEGHLEVTKYLVQ------------------- 193
Cdd:PHA02874  30 ISVDETTTPLIDAIRSGDAKIVELFIKHGAD-INHINTKIPHPLLTAIKIGAHDIIKLLIDngvdtsilpipciekdmik 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672055020 194 ---ECSADPHLRAQDGMTPLHAAAQMGHNPVLVWLVSF-ADVSFseQDHDGATAMHFAASRGHTKVLSWLLLHGAEIS-Q 268
Cdd:PHA02874 109 tilDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYgADVNI--EDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANvK 186

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 672055020 269 DLWGGTPLHDAAENGELECCQILAVNGAGLDVRDHDGYT 307
Cdd:PHA02874 187 DNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFT 225
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 108-307 3.57e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 50.43  E-value: 3.57e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672055020 108 LHLAARFGHPDVVNWLLYQgGANSAITTDTGALPIHYAA-----AKGDLPSMKLLVgHYPEGVNAQTNNGATPLYLACQE 182
Cdd:PHA03100  39 LYLAKEARNIDVVKILLDN-GADINSSTKNNSTPLHYLSnikynLTDVKEIVKLLL-EYGANVNAPDNNGITPLLYAISK 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672055020 183 --GHLEVTKYLVQEcSADPHLRAQDGMTPLHAAAQMGHNpvlvwlvsfadvsfseqdhdgatamhfaasrgHTKVLSWLL 260
Cdd:PHA03100 117 ksNSYSIVEYLLDN-GANVNIKNSDGENLLHLYLESNKI--------------------------------DLKILKLLI 163

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 672055020 261 LHGAEISQ-----------------DLWGGTPLHDAAENGELECCQILAVNGAGLDVRDHDGYT 307
Cdd:PHA03100 164 DKGVDINAknrvnyllsygvpinikDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDT 227
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 94-162 3.67e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 50.43  E-value: 3.67e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 672055020  94 GCRVQEKDNSGATVLHLAARFGHPDVVNWLLYQgGANSAITTDTGALPIHYAAAKGDLPSMKLLVGHYP 162
Cdd:PHA03100 182 GVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDL-GANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGP 249
Ank_5 pfam13857
Ankyrin repeats (many copies);
89-145 7.27e-06

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 43.87  E-value: 7.27e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 672055020   89 LLTQGGCRVQEKDNSGATVLHLAARFGHPDVVNWLLYQGGANSaITTDTGALPIHYA 145
Cdd:pfam13857   1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLN-LKDEEGLTALDLA 56
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 146-234 3.70e-05

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 47.59  E-value: 3.70e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672055020 146 AAKGDLPSMKLLV--GHYPegvNAQTNNGATPLYLACQEGHLEVTKYLVqECSADPHLRAQDGMTPLHAAAQMGHNPVLV 223
Cdd:PTZ00322  90 AASGDAVGARILLtgGADP---NCRDYDGRTPLHIACANGHVQVVRVLL-EFGADPTLLDKDGKTPLELAEENGFREVVQ 165

                         90
                 ....*....|.
gi 672055020 224 WLVSFADVSFS 234
Cdd:PTZ00322 166 LLSRHSQCHFE 176
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 229-307 6.20e-05

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 46.41  E-value: 6.20e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672055020 229 ADVSFSEQdHDGATAMHFAASRGHTKVLSWLLLHGAEI-SQDLWGGTPLHDAAENGELECCQILAVNGAGLDVRDHDGYT 307
Cdd:PHA02878 158 ADINMKDR-HKGNTALHYATENKDQRLTELLLSYGANVnIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNT 236
PHA02946 PHA02946
ankyin-like protein; Provisional
 90-276 7.26e-05

ankyin-like protein; Provisional


Pssm-ID: 165256 [Multi-domain]  Cd Length: 446  Bit Score: 46.20  E-value: 7.26e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672055020  90 LTQGGCRVQEKDNSGATVLHLAARFGHPDVVNWLLYQGGANSAITTDTGAlPIHYAAAKGD--LPSMKLLVGHYPEGVNA 167
Cdd:PHA02946  58 LLHRGYSPNETDDDGNYPLHIASKINNNRIVAMLLTHGADPNACDKQHKT-PLYYLSGTDDevIERINLLVQYGAKINNS 136

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672055020 168 QTNNGATPLyLACQEGHLEVTKYLVQeCSADPHLRAQDGMTPLHAAAqMGHNP---VLVWLVSFAdVSFSEQDHDGATAM 244
Cdd:PHA02946 137 VDEEGCGPL-LACTDPSERVFKKIMS-IGFEARIVDKFGKNHIHRHL-MSDNPkasTISWMMKLG-ISPSKPDHDGNTPL 212

                        170       180       190
                 ....*....|....*....|....*....|....
gi 672055020 245 HFAASRGHTKV-LSWLLLHGAEIS-QDLWGGTPL 276
Cdd:PHA02946 213 HIVCSKTVKNVdIINLLLPSTDVNkQNKFGDSPL 246
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 197-268 8.47e-05

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 46.43  E-value: 8.47e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 672055020 197 ADPHLRAQDGMTPLHAAAQMGHNPVLVWLVSF-ADVSFSeqDHDGATAMHFAASRGHTKVLSWLLLHGAEISQ 268
Cdd:PTZ00322 106 ADPNCRDYDGRTPLHIACANGHVQVVRVLLEFgADPTLL--DKDGKTPLELAEENGFREVVQLLSRHSQCHFE 176
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 150-324 2.30e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 44.60  E-value: 2.30e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672055020 150 DLPSMKLLVGHYPegvNAQTNNGATPLYLACQEGHLEVTKYLVQEcSADPHLRAQDGMTPLHAAAQMGHN---PVLVWLV 226
Cdd:PHA02875  16 DIARRLLDIGINP---NFEIYDGISPIKLAMKFRDSEAIKLLMKH-GAIPDVKYPDIESELHDAVEEGDVkavEELLDLG 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672055020 227 SFADVSFSEqdhDGATAMHFAASRGHTKVLSWLLLHGAEI---SQDLWggTPLHDAAENGELECCQILAVNGAGLDVRDH 303
Cdd:PHA02875  92 KFADDVFYK---DGMTPLHLATILKKLDIMKLLIARGADPdipNTDKF--SPLHLAVMMGDIKGIELLIDHKACLDIEDC 166

                        170       180
                 ....*....|....*....|.
gi 672055020 304 DGYTAADLADFNGHTHCSRYL 324
Cdd:PHA02875 167 CGCTPLIIAMAKGDIAICKML 187
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 149-326 2.70e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 44.18  E-value: 2.70e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672055020 149 GDLPSMKLLVGHYPEGVNAQTNNGATPLYLACQEGHLEVTKYLVQECSADPHLRAQDGmTPLHAAAQMGHNPVL-VWLVS 227
Cdd:PHA02874  12 GDIEAIEKIIKNKGNCINISVDETTTPLIDAIRSGDAKIVELFIKHGADINHINTKIP-HPLLTAIKIGAHDIIkLLIDN 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672055020 228 FADVSF---------------------SEQDHDGATAMHFAASRGHTKVLSWLLLHGAEIS-QDLWGGTPLHDAAENGEL 285
Cdd:PHA02874  91 GVDTSIlpipciekdmiktildcgidvNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNiEDDNGCYPIHIAIKHNFF 170

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 672055020 286 ECCQILAVNGAGLDVRDHDGYTAADLADFNGHTHCSRYLRT 326
Cdd:PHA02874 171 DIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIKLLID 211
Ank_5 pfam13857
Ankyrin repeats (many copies);
191-247 3.63e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 39.25  E-value: 3.63e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 672055020  191 LVQECSADPHLRAQDGMTPLHAAAQMGHNPVLVWLVSFaDVSFSEQDHDGATAMHFA 247
Cdd:pfam13857   1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAY-GVDLNLKDEEGLTALDLA 56
Ank_5 pfam13857
Ankyrin repeats (many copies);
123-179 5.71e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 38.48  E-value: 5.71e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 672055020  123 LLYQGGANSAITTDTGALPIHYAAAKGDLPSMKLLVGhYPEGVNAQTNNGATPLYLA 179
Cdd:pfam13857   1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLA-YGVDLNLKDEEGLTALDLA 56
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 171-201 8.74e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 37.57  E-value: 8.74e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 672055020   171 NGATPLYLACQEGHLEVTKYLVQEcSADPHL 201
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDK-GADINA 30
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 68-193 9.06e-04

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 42.73  E-value: 9.06e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672055020  68 RNGATPAHDAAAT--GYLSCLQWLLtQGGCRVQEKDNSGATVLHLAARFGHPD--VVNWLLYQG---------------G 128
Cdd:PHA03100 104 NNGITPLLYAISKksNSYSIVEYLL-DNGANVNIKNSDGENLLHLYLESNKIDlkILKLLIDKGvdinaknrvnyllsyG 182

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 672055020 129 ANSAITTDTGALPIHYAAAKGDLPSMKLLVgHYPEGVNAQTNNGATPLYLACQEGHLEVTKYLVQ 193
Cdd:PHA03100 183 VPINIKDVYGFTPLHYAVYNNNPEFVKYLL-DLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLN 246
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 123-294 9.35e-04

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 42.56  E-value: 9.35e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672055020 123 LLYQGGANSAITT-DTGALPIHYAAAKGDLPSMKLLVGhYPEGVNAQTNNGATPLYLACQEGHLEVTKYLVQECSADPHl 201
Cdd:PHA02878 152 LLLSYGADINMKDrHKGNTALHYATENKDQRLTELLLS-YGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDA- 229

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672055020 202 RAQDGMTPLHAAAQMGHNPVLVWLVSFADVSFSEQDH-DGATAMHFAASrgHTKVLSWLLLHGAEI-SQDLWGGTPLHDA 279
Cdd:PHA02878 230 RDKCGNTPLHISVGYCKDYDILKLLLEHGVDVNAKSYiLGLTALHSSIK--SERKLKLLLEYGADInSLNSYKLTPLSSA 307

                        170
                 ....*....|....*.
gi 672055020 280 AEN-GELECCQILAVN 294
Cdd:PHA02878 308 VKQyLCINIGRILISN 323
TRPV cd21882
Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily ...
 80-260 1.06e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily (TRPV), named after the vanilloid receptor 1 (TRPV1), consists of six members: four thermo-sensing channels (TRPV1, TRPV2, TRPV3, and TRPV4) and two Ca2+ selective channels (TRPV5 and TRPV6). The calcium-selective channels TRPV5 and TRPV6 can be heterotetramers and are important for general Ca2+ homeostasis. All four channels within the TRPV1-4 group show temperature-invoked currents when expressed in heterologous cell systems, ranging from activation at ~25C for TRPV4 to ~52C for TRPV2. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains. The TRP family consists of membrane proteins that function as ion channels that communicate between the cell and its environment, by a vast array of physical or chemical stimuli, including radiation (in the form of temperature, infrared ,or light) and pressure (osmotic or mechanical). TRP channels are formed by a tetrameric complex of channel subunits. Based on sequence identity, the mammalian TRP channel family is classified into six subfamilies, with significant sequence similarity within the transmembrane domains, but very low similarity in their N- and C-terminal cytoplasmic regions. The six subfamilies are named based on their first member: TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPA (ankyrin), TRPML (mucolipin), and TRPP (polycystic).


Pssm-ID: 411975 [Multi-domain]  Cd Length: 600  Bit Score: 42.56  E-value: 1.06e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672055020  80 TGYLSCLQWLLTQggcRVQEKDNSGATVLHLAARFGHPDVVN--WLLYQGGANS--------AITTDT---GALPIHYAA 146
Cdd:cd21882    5 LGLLECLRWYLTD---SAYQRGATGKTCLHKAALNLNDGVNEaiMLLLEAAPDSgnpkelvnAPCTDEfyqGQTALHIAI 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672055020 147 AKGDLPSMKLLVGHYPEgVNAQTNN-------------GATPLYLACQEGHLEVTKYLVQEcSADPH-LRAQD--GMTPL 210
Cdd:cd21882   82 ENRNLNLVRLLVENGAD-VSARATGrffrkspgnlfyfGELPLSLAACTNQEEIVRLLLEN-GAQPAaLEAQDslGNTVL 159

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672055020 211 HA--------------AAQMgHNPVLVW------LVSFADVSfseqDHDGATAMHFAASRGHTKVLSWLL 260
Cdd:cd21882  160 HAlvlqadntpensafVCQM-YNLLLSYgahldpTQQLEEIP----NHQGLTPLKLAAVEGKIVMFQHIL 224
Ank_5 pfam13857
Ankyrin repeats (many copies);
55-111 1.11e-03

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 37.71  E-value: 1.11e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 672055020   55 LVEEVALPAVSRARNGATPAHDAAATGYLSCLQWLLTqGGCRVQEKDNSGATVLHLA 111
Cdd:pfam13857   1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLA-YGVDLNLKDEEGLTALDLA 56
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 239-267 1.22e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 36.85  E-value: 1.22e-03
                          10        20
                  ....*....|....*....|....*....
gi 672055020  239 DGATAMHFAASRGHTKVLSWLLLHGAEIS 267
Cdd:pfam13606   1 DGNTPLHLAARNGRLEIVKLLLENGADIN 29
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 237-291 1.82e-03

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 41.81  E-value: 1.82e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 672055020 237 DHDGATAMHFAASRGHTKVLSWLLLHGAEIS-QDLWGGTPLHDAAENGELECCQIL 291
Cdd:PTZ00322 112 DYDGRTPLHIACANGHVQVVRVLLEFGADPTlLDKDGKTPLELAEENGFREVVQLL 167
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 89-188 2.47e-03

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 41.42  E-value: 2.47e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672055020  89 LLTQGGCRVQEKDNSGATVLHLAARFGHPDVVNWLLyQGGANSAITTDTGALPIHYAAAKGDLPSMKLLVGHYPEGVNAQ 168
Cdd:PTZ00322 100 ILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLL-EFGADPTLLDKDGKTPLELAEENGFREVVQLLSRHSQCHFELG 178

                         90       100
                 ....*....|....*....|
gi 672055020 169 TNngATPLYLACQEGHLEVT 188
Cdd:PTZ00322 179 AN--AKPDSFTGKPPSLEDS 196
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 239-266 4.56e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 35.26  E-value: 4.56e-03
                           10        20
                   ....*....|....*....|....*...
gi 672055020   239 DGATAMHFAASRGHTKVLSWLLLHGAEI 266
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADI 28
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 183-316 4.82e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 40.36  E-value: 4.82e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672055020 183 GHLEVTKYLVqECSADPHLRAQDGMTPLHAAAQMGHNPVLVWLVSFADVSfSEQDHDGATAMHFAASRGHTKVLSWLLLH 262
Cdd:PHA02875  13 GELDIARRLL-DIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIP-DVKYPDIESELHDAVEEGDVKAVEELLDL 90

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 672055020 263 GAEISQDLW--GGTPLHDAAENGELECCQILAVNGAGLDVRDHDGYTAADLA----DFNG 316
Cdd:PHA02875  91 GKFADDVFYkdGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAvmmgDIKG 150
Ank_5 pfam13857
Ankyrin repeats (many copies);
157-213 5.14e-03

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 35.79  E-value: 5.14e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 672055020  157 LVGHYPEGVNAQTNNGATPLYLACQEGHLEVTKYLVqECSADPHLRAQDGMTPLHAA 213
Cdd:pfam13857   1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLL-AYGVDLNLKDEEGLTALDLA 56
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 171-202 5.64e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 35.34  E-value: 5.64e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 672055020  171 NGATPLYLAC-QEGHLEVTKYLVQeCSADPHLR 202
Cdd:pfam00023   1 DGNTPLHLAAgRRGNLEIVKLLLS-KGADVNAR 32
WH2 pfam02205
WH2 motif; The WH2 motif (for Wiskott Aldrich syndrome homology region 2) has been shown in ...
 666-691 6.48e-03

WH2 motif; The WH2 motif (for Wiskott Aldrich syndrome homology region 2) has been shown in WASP and Scar1 (mammalian homolog) to be the region that interacts with actin.


Pssm-ID: 460490  Cd Length: 28  Bit Score: 34.78  E-value: 6.48e-03
                          10        20
                  ....*....|....*....|....*.
gi 672055020  666 PTGDNSELLAEIKAGKSLKPTPQSKG 691
Cdd:pfam02205   1 GGGGRGALLADIRAGKKLKKVEETND 26
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 72-267 8.42e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 39.66  E-value: 8.42e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672055020  72 TPAHDAAATGYLSCLQWLLTQGGCRVQEKDNSGATVLHLAARFGHPDVVNWLLYQGGANSAITTDTGALPIHYAAAKGDL 151
Cdd:PHA02876 275 TPLHHASQAPSLSRLVPKLLERGADVNAKNIKGETPLYLMAKNGYDTENIRTLIMLGADVNAADRLYITPLHQASTLDRN 354

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672055020 152 PSMKLLVGHYPEGVNAQTNNGATPLYLACQEGHLEVTKYLVqECSADPHLRAQDGMTPLHAAAqMGHNPVL-VWLVSFAD 230
Cdd:PHA02876 355 KDIVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLL-DYGADIEALSQKIGTALHFAL-CGTNPYMsVKTLIDRG 432

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 672055020 231 VSFSEQDHDGATAMHFAASRG-HTKVLSWLLLHGAEIS 267
Cdd:PHA02876 433 ANVNSKNKDLSTPLHYACKKNcKLDVIEMLLDNGADVN 470
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 239-266 9.14e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 34.57  E-value: 9.14e-03
                          10        20
                  ....*....|....*....|....*....
gi 672055020  239 DGATAMHFAASR-GHTKVLSWLLLHGAEI 266
Cdd:pfam00023   1 DGNTPLHLAAGRrGNLEIVKLLLSKGADV 29
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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