second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 7 (BTBD7); BTBD7 is a crucial regulator that is essential for region-specific epithelial cell dynamics and branching morphogenesis. It has been implicated in various cancers. BTBD7 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672056687  245 CYYDVVLSFSSDSELVEAFGGNQNCLDEELKAHKAIISARSPFFRNLLQRRIRTGEeitDRTLRTPTRIILDESIIPKKY 324
Cdd:cd18284     1 DYGDAVLVFASDKETVESSSGKVNEPDFELRCHKAILSARSPFFRNLLQRRIRTGE---DRTLSTPTRIVLDESIIPRRY 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 672056687  325 AKVILHCMYTDVVDLS-VLHCSPSVGSLSEVQALVAGKPNMTRAEEAMELYHIALFLEFNMLAQGCEDI 392
Cdd:cd18284    78 ARVLLHAMYTDSVDLSlILRSSPSESSLSEVQAIVAGKGPETRLEEAMELYHIARFLEFDILAQGCEDI 146

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 7 (BTBD7); BTBD7 is a crucial regulator that is essential for region-specific epithelial cell dynamics and branching morphogenesis. It has been implicated in various cancers. BTBD7 contains two BTB domains. This model corresponds to the first domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672056687  140 YCTDVDLIFQETCFPVHRAILAARCPFFKTLLSSSPEYGAEIIMDISTAGIDMPMFSALLHYLYTGEFGMEDSRFQNVDI 219
Cdd:cd18283     1 YCTDVDLVFQGTCFPVHRAILSARCPFFRDLLSSSPGYGAEIPVDLPTAGIDVPMFSALLRYLYTGEFGSEDSRSQNLDV 80

                          90
                  ....*....|..
gi 672056687  220 LVQLSEEFGTPN 231
Cdd:cd18283    81 LIQLSEEFGTPN 92

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 7 (BTBD7); BTBD7 is a crucial regulator that is essential for region-specific epithelial cell dynamics and branching morphogenesis. It has been implicated in various cancers. BTBD7 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672056687  245 CYYDVVLSFSSDSELVEAFGGNQNCLDEELKAHKAIISARSPFFRNLLQRRIRTGEeitDRTLRTPTRIILDESIIPKKY 324
Cdd:cd18284     1 DYGDAVLVFASDKETVESSSGKVNEPDFELRCHKAILSARSPFFRNLLQRRIRTGE---DRTLSTPTRIVLDESIIPRRY 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 672056687  325 AKVILHCMYTDVVDLS-VLHCSPSVGSLSEVQALVAGKPNMTRAEEAMELYHIALFLEFNMLAQGCEDI 392
Cdd:cd18284    78 ARVLLHAMYTDSVDLSlILRSSPSESSLSEVQAIVAGKGPETRLEEAMELYHIARFLEFDILAQGCEDI 146

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 7 (BTBD7); BTBD7 is a crucial regulator that is essential for region-specific epithelial cell dynamics and branching morphogenesis. It has been implicated in various cancers. BTBD7 contains two BTB domains. This model corresponds to the first domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672056687  140 YCTDVDLIFQETCFPVHRAILAARCPFFKTLLSSSPEYGAEIIMDISTAGIDMPMFSALLHYLYTGEFGMEDSRFQNVDI 219
Cdd:cd18283     1 YCTDVDLVFQGTCFPVHRAILSARCPFFRDLLSSSPGYGAEIPVDLPTAGIDVPMFSALLRYLYTGEFGSEDSRSQNLDV 80

                          90
                  ....*....|..
gi 672056687  220 LVQLSEEFGTPN 231
Cdd:cd18283    81 LIQLSEEFGTPN 92

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672056687    143 DVDLIFQETCFPVHRAILAARCPFFKTLLSSSPEYG--AEIIMDistaGIDMPMFSALLHYLYTGEFGMEDsrfQNVDIL 220
Cdd:smart00225    1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESdkSEIYLD----DVSPEDFRALLNFLYTGKLDLPE---ENVEEL 73

                            90
                    ....*....|
gi 672056687    221 VQLSEEFGTP 230
Cdd:smart00225   74 LELADYLQIP 83

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672056687    268 NCLDEELKAHKAIISARSPFFRNLLQRRIRTGEEitdrtlrtpTRIILDEsiIPKKYAKVILHCMYTDVVDLSvlhcsps 347
Cdd:smart00225    5 VVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDK---------SEIYLDD--VSPEDFRALLNFLYTGKLDLP------- 66

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|
gi 672056687    348 vgslsevqalvagkpnmtrAEEAMELYHIALFLEFNMLAQGCEDIIAESI 397
Cdd:smart00225   67 -------------------EENVEELLELADYLQIPGLVELCEEFLLKLL 97

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672056687   269 CLDEELKAHKAIISARSPFFRNLLQrriRTGEEITDRTlrtptrIILDEsiIPKKYAKVILHCMYTDVVDlsvlhcspsv 348
Cdd:pfam00651   17 VGDKEFRAHKAVLAACSPYFKALFS---GQESESSVSE------ITLDD--VSPEDFEALLEFMYTGKLI---------- 75

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 672056687   349 gslsevqalvagkpnmtRAEEAMELYHIALFLEFNMLAQGCEDIIAESI 397
Cdd:pfam00651   76 -----------------SEENVDDLLAAADKLQIPSLVDKCEEFLIKSL 107

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 7 (BTBD7); BTBD7 is a crucial regulator that is essential for region-specific epithelial cell dynamics and branching morphogenesis. It has been implicated in various cancers. BTBD7 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672056687  245 CYYDVVLSFSSDSELVEAFGGNQNCLDEELKAHKAIISARSPFFRNLLQRRIRTGEeitDRTLRTPTRIILDESIIPKKY 324
Cdd:cd18284     1 DYGDAVLVFASDKETVESSSGKVNEPDFELRCHKAILSARSPFFRNLLQRRIRTGE---DRTLSTPTRIVLDESIIPRRY 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 672056687  325 AKVILHCMYTDVVDLS-VLHCSPSVGSLSEVQALVAGKPNMTRAEEAMELYHIALFLEFNMLAQGCEDI 392
Cdd:cd18284    78 ARVLLHAMYTDSVDLSlILRSSPSESSLSEVQAIVAGKGPETRLEEAMELYHIARFLEFDILAQGCEDI 146

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 7 (BTBD7); BTBD7 is a crucial regulator that is essential for region-specific epithelial cell dynamics and branching morphogenesis. It has been implicated in various cancers. BTBD7 contains two BTB domains. This model corresponds to the first domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672056687  140 YCTDVDLIFQETCFPVHRAILAARCPFFKTLLSSSPEYGAEIIMDISTAGIDMPMFSALLHYLYTGEFGMEDSRFQNVDI 219
Cdd:cd18283     1 YCTDVDLVFQGTCFPVHRAILSARCPFFRDLLSSSPGYGAEIPVDLPTAGIDVPMFSALLRYLYTGEFGSEDSRSQNLDV 80

                          90
                  ....*....|..
gi 672056687  220 LVQLSEEFGTPN 231
Cdd:cd18283    81 LIQLSEEFGTPN 92

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672056687   137 EYKYCtDVDLIFQETCFPVHRAILAARCPFFKTLLSSSPE--YGAEIIMDistaGIDMPMFSALLHYLYTGEFGMEDsrf 214
Cdd:pfam00651    7 QGELC-DVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESesSVSEITLD----DVSPEDFEALLEFMYTGKLISEE--- 78

                           90       100
                   ....*....|....*....|.
gi 672056687   215 qNVDILVQLSEEFGTPNSLDV 235
Cdd:pfam00651   79 -NVDDLLAAADKLQIPSLVDK 98

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. In vertebrates, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672056687  130 KDMADLYEYKYCTDVDLIFQE-TCFPVHRAILAARCPFFKTLLSsspeYGAEIIMDIStagIDMPMFSALLHYLYTGEFG 208
Cdd:cd18299     1 EDLRNLLHSPSCADVVFILQGgVRIFAHRIVLAAASSVFADLFL----MMTVVTLDSD---ITPEAFRRVLEFLYTGVLD 73

                          90
                  ....*....|....*..
gi 672056687  209 MEDSRFQNVDILVQLSE 225
Cdd:cd18299    74 ENEDDLKELKDAAELLE 90

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672056687    410 SHPYGSKWVHRQALHFLCEELSQVMTSDVFYELSKDHLLTAIQSDYLQ-ASEQDILKYLIKWGEHQLMKRIaDREPNLLS 488
Cdd:smart00875    8 ADAHGLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSSDDLNvSSEEEVFEAVLRWVKHDPEKRR-EHLPELLE 86

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672056687  136 YEYKYCTDVDLIFQETCFPVHRAILAARCPFFKTLLSSSPEYGAEiiMDISTAGIDMPMFSALLHYLYTGEFGMEDsrfQ 215
Cdd:cd18314     1 YNDSEFSDVVLCVGDRKFFAHRIVLCARSPVFRSMLTGSMIESNL--KEVTLEDVEPEIFETVLKYMYTGQVTLSE---E 75

                          90
                  ....*....|....*
gi 672056687  216 NVDILVQLSEEFGTP 230
Cdd:cd18314    76 NVLDLLMLASKYQVP 90

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 672056687  271 DEELKAHKAIISARSPFFRNLLQRRIRTGEEitdrtlrtpTRIILDEsiIPKKYAKVILHCMYTDVVDLSV 341
Cdd:cd18186    10 GREFPAHRAVLAARSPYFRAMFSSGMKESSS---------SEIELDD--VSPEAFEALLDYIYTGELELSE 69

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also termed BTB and kelch domain-containing protein 3 (BKLHD3), is a BTB-Kelch family protein. Its function remains unclear.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672056687  397 ISLETLIAILKWSShPYGSKWVHRQALHFLCEELSQVMTSDVFYELSKDHLLTAIQSDYLQ-ASEQDILKYLIKWGEHQL 475
Cdd:cd18480     1 LDLSNCLQLLSFAE-SYGSTRLLDHALEFVMQHFSLLSQSQEFLELNFEVLEKILEADELNvPDEEAVLKAVLRWTKHDL 79

                  ...
gi 672056687  476 MKR 478
Cdd:cd18480    80 EAR 82

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672056687    268 NCLDEELKAHKAIISARSPFFRNLLQRRIRTGEEitdrtlrtpTRIILDEsiIPKKYAKVILHCMYTDVVDLSvlhcsps 347
Cdd:smart00225    5 VVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDK---------SEIYLDD--VSPEDFRALLNFLYTGKLDLP------- 66

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|
gi 672056687    348 vgslsevqalvagkpnmtrAEEAMELYHIALFLEFNMLAQGCEDIIAESI 397
Cdd:smart00225   67 -------------------EENVEELLELADYLQIPGLVELCEEFLLKLL 97

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 4 (ZBTB4); ZBTB4, also called KAISO-like zinc finger protein 1 (KAISO-L1), is a transcriptional repressor with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It can also bind specifically to a single methyl-CpG pair and can bind hemimethylated DNA but with a lower affinity compared to methylated DNA. ZBTB4 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672056687  140 YCtDVDLIFQETCFPVHRAILAARCPFFKTLLSSSPEYGAEIIMDISTA-----------GIDMPMFSALLHYLYTGEFG 208
Cdd:cd18195    18 FC-DVTLIAGDTKFRAHRSVLAASSPYFRELLSSPLPLGAAAVAAAPGAtqspervlelpGVKAGVFSDVLNFIYSSRVA 96

                  ....*
gi 672056687  209 MEDSR 213
Cdd:cd18195    97 LPGSA 101

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672056687  128 LQKDMADLYEYKYCTDVDLIFQETCFPV--HRAILAARCPFFKTLLSSSPEYGAE----IIMDISTAgidmpMFSALLHY 201
Cdd:cd18294     1 FAADMKSLINNPEFSDVKFLVGPERQEIfaHKCILAARCEVFRAMFLTGPQKESTqsplVLSDIEPE-----VFRAVLEF 75

                          90       100
                  ....*....|....*....|....*....
gi 672056687  202 LYTG-----------------EFGMEDSR 213
Cdd:cd18294    76 IYTNcvtlsnhtvievlaaavEYGLDELR 104

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 10 (KLHL10); KLHL10 is a substrate-specific adaptor of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins specifically in the testis during spermatogenesis. Haploinsufficiency of Klhl10 causes infertility in male mice. KLHL10 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672056687  139 KYCtDVDLIFQETCFPVHRAILAARCPFFKTLLSSSPEYGAEIIMDIStaGIDMPMFSALLHYLYTGEFgmeDSRFQNVD 218
Cdd:cd18240    16 KLC-DVVIRVNGVEFPAHRNILCACSPYFRALFTNGWNETEKKVYKIP--GVSPEMMELIIEYAYTRTV---PITAENVE 89

                  ....*....
gi 672056687  219 ILVQLSEEF 227
Cdd:cd18240    90 ELLPAADQF 98

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672056687  128 LQKDMADLYEYKYCTDV--DLIFQ---ETcFPVHRAILAARCPFFKTLLSSSPEYGAEIIMDISTAGIDMP--MFSALLH 200
Cdd:cd18301     1 FQEDFKKLLDEADEGDNihDVVFQvggKT-FPAHKFILASRSDYFRKLFLSSLLTSEDAVGCDVVHIEKVPpeIFEQLLQ 79

                  ....*
gi 672056687  201 YLYTG 205
Cdd:cd18301    80 FIYTD 84

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 672056687  142 TDVDLIFQETCFPVHRAILAARCPFFKTLLSS-SPEYGAEIIMDISTAGIdmpmFSALLHYLYTGE 206
Cdd:cd18315     2 VDVTLACEGGSLKAHKLVLAAASPYFAALLKEtPPDEHPVIILPDVPYSE----LKALLDFIYTGE 63

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein-like (SPOPL); SPOPL, also called HIB homolog 2 or Roadkill homolog 2, is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The complexes may contain homodimeric SPOPL or the heterodimers formed by speckle-type POZ protein (SPOP) and SPOPL, which are less efficient than ubiquitin ligase complexes containing only SPOP. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672056687  120 LARPEARtLQKDMADLYEYKYCTDVDLIFQETCFPVHRAILAARCPFFKTLLSSSPEYGAEIIMDISTagIDMPMFSALL 199
Cdd:cd18343     1 LKVPECR-LAEDLGNLWENSRFTDCSLFVGGQEFKAHKSILAARSPVFNAMFEHEMEESKKNRVEIND--VDPEVFKEMM 77

                  ....*.
gi 672056687  200 HYLYTG 205
Cdd:cd18343    78 RFIYTG 83

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also called galectin-3-binding protein-like, is a BTB domain-containing protein. Its function remains unclear. It may be associated with hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672056687  125 ARTLQKDMADLYEYKYCTDVDLIFQETCFPVHRAILAARCPFFKTLLSSSPEYGA---EIIMDISTAGIDmpMFSALLHY 201
Cdd:cd18292     1 SREFLQDIAQLYNNEELSDIVLRVGGKVFHAHRLILAKSSDVFRVMLSNDWWSESkqsEIELVEDPECAA--VFEKFLRY 78

                  ....*
gi 672056687  202 LYTGE 206
Cdd:cd18292    79 LYTGQ 83

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672056687   269 CLDEELKAHKAIISARSPFFRNLLQrriRTGEEITDRTlrtptrIILDEsiIPKKYAKVILHCMYTDVVDlsvlhcspsv 348
Cdd:pfam00651   17 VGDKEFRAHKAVLAACSPYFKALFS---GQESESSVSE------ITLDD--VSPEDFEALLEFMYTGKLI---------- 75

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 672056687   349 gslsevqalvagkpnmtRAEEAMELYHIALFLEFNMLAQGCEDIIAESI 397
Cdd:pfam00651   76 -----------------SEENVDDLLAAADKLQIPSLVDKCEEFLIKSL 107

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulation of insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672056687  125 ARTLQKDMADLYEYKYCTDVDLIFQETCFPVHRAILAARCPFFKTLLSSSPEYGAEiiMDISTAGIDMPMFSALLHYLYT 204
Cdd:cd18270    10 AVSLLEQLKFFYEQQLLTDIVLIVEGTEFPCHKMVLATCSSYFRAMFMSGLSESKQ--THVHLRNVDAATLQIIITYAYT 87

                          90       100       110
                  ....*....|....*....|....*....|..
gi 672056687  205 GEFGMEDSR---------FQNVDILVQLSEEF 227
Cdd:cd18270    88 GNLAINDSTveqlyetacFLQVEDVLQRCREY 119

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in telomere zinc finger-associated protein (TZAP); TZAP is also called Krueppel-related zinc finger protein 3 (KR3), zinc finger and BTB domain-containing protein 48 (ZBTB48), or zinc finger protein 855 (ZNF855). It is a vertebrate telomere-binding protein involved in telomere length control. It directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. TZAP also acts as a transcription regulator that binds to promoter regions. It is a transcriptional activator of alternate reading frame (ARF) gene. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672056687  137 EYKYCtDVDLIFQETCFPVHRAILAARCPFFKTLLSSSPeyGAEIIMDISTAGIdmpmFSALLHYLYTGEFGMEDsrfQN 216
Cdd:cd18232    15 EGQYC-DATLDVGGRVFKAHWSVLACCSHFFQSLYGDGT--SGSVVLPESFAEV----FGLLLDFFYTGELALTR---EN 84

                          90
                  ....*....|....*....
gi 672056687  217 VDILVQLSEEFGTPNSLDV 235
Cdd:cd18232    85 RDRVLLAAKELRVPEAVEL 103

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672056687  144 VDLIFQETCFPVHRAILAARCPFFKTLLSSSPEYG--AEIIMDistaGIDMPMFSALLHYLYTGEFGMEDSrfqNVDILV 221
Cdd:cd01165     1 VVLVVEGEKFHVNKELLAQSSEYFRALFRGGFRESgqAEINLR----DISPEDFRALLEFLYGGKRDLDAS---NLLELL 73

                  ..
gi 672056687  222 QL 223
Cdd:cd01165    74 EA 75

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in calicin; Calicin is a basic cytoskeletal protein involved in the formation and maintenance of the highly regular organization of the postacrosomal perinuclear theca, the calyx of mammalian spermatozoa. It contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672056687  141 CTDVDLIFQETCFPVHRAILAARCPFFKTLLSSSPEYGA-EIIMDISTAGIDMPMFSALLHYLYTGEFGMEDsrfQNVDI 219
Cdd:cd18307     1 FCDVVISVDNHSFAAHRNVLAAVSPFVKSLISSNDMKATdELSITIDCDYLSPETVEQLLDYFYTGKIVISE---KNVED 77

                          90
                  ....*....|....*
gi 672056687  220 LVQLSEEFGTPNSLD 234
Cdd:cd18307    78 LLKGAKYFNIPRLKD 92

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in TD and POZ domain-containing proteins (TDPOZ); TDPOZ is a family of bipartite animal and plant proteins that contains a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domain. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. This subfamily contains only mammalian members. Plant TDPOZ proteins contain a MATH domain at the N-terminal region and are named "BTB/POZ and MATH domain-containing proteins (BPM)", not included in this subfamily. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672056687  127 TLQKDMADLYEYKYCTDVDLIFQETCFPVHRAILAARCPFFKTLLSSSPEYGAEIIMDISTagIDMPMFSALLHYLYTGE 206
Cdd:cd18344     9 MLTDDLGELWENSLFTDCCLLVAGHEFRAHKAILAARSPVFRAMFEHEMEERLKNPIEIHD--LDPQVFKEMMGFIYTGK 86

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for a Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672056687  139 KYCtDVDLIFQETCFPVHRAILAARCPFFKTLLSSSPeygAEIIMD-ISTAGIDMPMFSALLHYLYTGEFGMEDSRFQNV 217
Cdd:cd18247    18 KLC-DVTLKVGDQKFSAHRIVLAATIPYFHAMFTHDM---VESKQDeITMQGIEPSALEALINFAYSGRIAIDTSNVQSL 93

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the first domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672056687  128 LQKDMADLYEYKYCTDVDLIFQETCFPVHRAILAARCP--FFKTLLSSSPEYGAEIimdISTAGIDMPMFSALLHYLYTg 205
Cdd:cd18285     2 LSQDLLRLLREELHTDVTFYVGSTLFKAHKAILLARVPefFSHIIGKLSSLEDQEP---INIENLEASEFKTFLRQVYT- 77

                          90       100       110
                  ....*....|....*....|....*....|..
gi 672056687  206 efgmedsrfQNVDIlVQLSEEFGTPNSLDVDM 237
Cdd:cd18285    78 ---------SDKNI-KMLEEEILKGKVLDQKV 99

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 1 (NAC-1); NAC-1, also called BTB/POZ domain-containing protein 14B (BTBD14B), is a transcriptional repressor that contributes to tumor progression, tumor cell proliferation, and survival. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672056687  140 YCtDVDLIFQETCFPVHRAILAARCPFFKTLLSSSPEYGAEIimdisTAGIDMPMFSALLHYLYTGEFGM 209
Cdd:cd18290    27 YC-DVSVVVKGHAFKAHRAVLAASSSYFRDLFNSSRSAVVEL-----PAAVQPQSFQQILSFCYTGRLSM 90