NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|672062932|ref|XP_008764731|]
View 

NCK-interacting protein with SH3 domain isoform X2 [Rattus norvegicus]

Protein Classification

DUF2013 domain-containing protein( domain architecture ID 10559551)

DUF2013 domain-containing protein similar to Saccharomyces cerevisiae protein low dye-binding protein 17 (LDB17) that may be involved in protein-linked oligosaccharide phosphorylation

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
SPIN90_LRD pfam09431
SPIN90/Ldb17, leucine-rich domain; This is the conserved leucine-rich domain (LRD) within the ...
 504-617 2.45e-44

SPIN90/Ldb17, leucine-rich domain; This is the conserved leucine-rich domain (LRD) within the C-terminal domain of SPIN90 (also known as NCK interacting protein with SH3 domain (NCKIPSD)) from animals, Ldb17 from budding yeasts and Dip1 from fission yeasts. Ldb17 is involved in the regulation of endocytosis in yeast. SPIN90 is an F-actin binding protein that regulates actin polymerization and endocytosis. It associates with and activates the Arp2/3 complex, without requiring a preformed actin filament. This LRD, within the C-terminal armadillo repeat (ARM) domain of SPIN90, is important for activation of Arp2/3 complex.


:

Pssm-ID: 462796  Cd Length: 135  Bit Score: 154.94  E-value: 2.45e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672062932  504 QNVIMAALSKHTNVKIFSEKLLLLLNRGDDPVRIFrhepqpphSVLKFLQDVFSSAATASIFYHTDMMALIDITVRQIAD 583
Cdd:pfam09431  29 ENKVLKVLSRLSSSKTFGENLLLLLNREEDPVLQL--------LILKLLYLIFTTPETAEYFYTNDLKVLIDIFIRELND 100

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 672062932  584 LS-PGDKLRMEYLSLMHAVVRSTPYLQHRHRLSDL 617
Cdd:pfam09431 101 LSeEGEKLRHTYLRVLYPLLRNTQLSEHHYKRDDL 135
PRK12323 super family cl46901
DNA polymerase III subunit gamma/tau;
172-254 8.99e-03

DNA polymerase III subunit gamma/tau;


The actual alignment was detected with superfamily member PRK07994:

Pssm-ID: 481241 [Multi-domain]  Cd Length: 647  Bit Score: 39.08  E-value: 8.99e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672062932 172 PSCSPTPPPVPRRS---AHTTVSQAQPSPSKAPSPEPPAEEVAAETNSAPDDLEALDALSPETTEEKPATETVVPRTIGA 248
Cdd:PRK07994 407 PQQAPAVPLPETTSqllAARQQLQRAQGATKAKKSEPAAASRARPVNSALERLASVRPAPSALEKAPAKKEAYRWKATNP 486


                 ....*.
gi 672062932 249 ELMELV 254
Cdd:PRK07994 487 VEVKKE 492
 
Name Accession Description Interval E-value
SPIN90_LRD pfam09431
SPIN90/Ldb17, leucine-rich domain; This is the conserved leucine-rich domain (LRD) within the ...
 504-617 2.45e-44

SPIN90/Ldb17, leucine-rich domain; This is the conserved leucine-rich domain (LRD) within the C-terminal domain of SPIN90 (also known as NCK interacting protein with SH3 domain (NCKIPSD)) from animals, Ldb17 from budding yeasts and Dip1 from fission yeasts. Ldb17 is involved in the regulation of endocytosis in yeast. SPIN90 is an F-actin binding protein that regulates actin polymerization and endocytosis. It associates with and activates the Arp2/3 complex, without requiring a preformed actin filament. This LRD, within the C-terminal armadillo repeat (ARM) domain of SPIN90, is important for activation of Arp2/3 complex.


Pssm-ID: 462796  Cd Length: 135  Bit Score: 154.94  E-value: 2.45e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672062932  504 QNVIMAALSKHTNVKIFSEKLLLLLNRGDDPVRIFrhepqpphSVLKFLQDVFSSAATASIFYHTDMMALIDITVRQIAD 583
Cdd:pfam09431  29 ENKVLKVLSRLSSSKTFGENLLLLLNREEDPVLQL--------LILKLLYLIFTTPETAEYFYTNDLKVLIDIFIRELND 100

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 672062932  584 LS-PGDKLRMEYLSLMHAVVRSTPYLQHRHRLSDL 617
Cdd:pfam09431 101 LSeEGEKLRHTYLRVLYPLLRNTQLSEHHYKRDDL 135
PRK07994 PRK07994
DNA polymerase III subunits gamma and tau; Validated
 172-254 8.99e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236138 [Multi-domain]  Cd Length: 647  Bit Score: 39.08  E-value: 8.99e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672062932 172 PSCSPTPPPVPRRS---AHTTVSQAQPSPSKAPSPEPPAEEVAAETNSAPDDLEALDALSPETTEEKPATETVVPRTIGA 248
Cdd:PRK07994 407 PQQAPAVPLPETTSqllAARQQLQRAQGATKAKKSEPAAASRARPVNSALERLASVRPAPSALEKAPAKKEAYRWKATNP 486


                 ....*.
gi 672062932 249 ELMELV 254
Cdd:PRK07994 487 VEVKKE 492
 
Name Accession Description Interval E-value
SPIN90_LRD pfam09431
SPIN90/Ldb17, leucine-rich domain; This is the conserved leucine-rich domain (LRD) within the ...
 504-617 2.45e-44

SPIN90/Ldb17, leucine-rich domain; This is the conserved leucine-rich domain (LRD) within the C-terminal domain of SPIN90 (also known as NCK interacting protein with SH3 domain (NCKIPSD)) from animals, Ldb17 from budding yeasts and Dip1 from fission yeasts. Ldb17 is involved in the regulation of endocytosis in yeast. SPIN90 is an F-actin binding protein that regulates actin polymerization and endocytosis. It associates with and activates the Arp2/3 complex, without requiring a preformed actin filament. This LRD, within the C-terminal armadillo repeat (ARM) domain of SPIN90, is important for activation of Arp2/3 complex.


Pssm-ID: 462796  Cd Length: 135  Bit Score: 154.94  E-value: 2.45e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672062932  504 QNVIMAALSKHTNVKIFSEKLLLLLNRGDDPVRIFrhepqpphSVLKFLQDVFSSAATASIFYHTDMMALIDITVRQIAD 583
Cdd:pfam09431  29 ENKVLKVLSRLSSSKTFGENLLLLLNREEDPVLQL--------LILKLLYLIFTTPETAEYFYTNDLKVLIDIFIRELND 100

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 672062932  584 LS-PGDKLRMEYLSLMHAVVRSTPYLQHRHRLSDL 617
Cdd:pfam09431 101 LSeEGEKLRHTYLRVLYPLLRNTQLSEHHYKRDDL 135
PRK07994 PRK07994
DNA polymerase III subunits gamma and tau; Validated
 172-254 8.99e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236138 [Multi-domain]  Cd Length: 647  Bit Score: 39.08  E-value: 8.99e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672062932 172 PSCSPTPPPVPRRS---AHTTVSQAQPSPSKAPSPEPPAEEVAAETNSAPDDLEALDALSPETTEEKPATETVVPRTIGA 248
Cdd:PRK07994 407 PQQAPAVPLPETTSqllAARQQLQRAQGATKAKKSEPAAASRARPVNSALERLASVRPAPSALEKAPAKKEAYRWKATNP 486


                 ....*.
gi 672062932 249 ELMELV 254
Cdd:PRK07994 487 VEVKKE 492
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH