NCBI Conserved Domain Search

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...

537-581

1.11e-13

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.

Pssm-ID: 396078 [Multi-domain] Cd Length: 46 Bit Score: 65.33 E-value: 1.11e-13

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 686585569  537 RRSRVSLVANCGRLYAVGGYDGQSNLSSVEMYDPETNRWTFMAPM 581
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSM 45

Name

Accession

Description

Interval

E-value

BACK_KLHL18

cd18457

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as ...

159-265

3.07e-76

Pssm-ID: 350532 [Multi-domain] Cd Length: 107 Bit Score: 237.21 E-value: 3.07e-76

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569 159 LHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPFEDVLELVSRDELNVKSEEQVFEAALAWIRYDRD 238
Cdd:cd18457    1 LHPNNCLGIRQFAETMMCSSLVDAANKYIQQHFIEVSKSEEFLALSKEEVLEILSRDELNVKSEEQVFEAALAWVKYDRE 80

                         90       100
                 ....*....|....*....|....*..
gi 686585569 239 QRESFLPELLSKIRLPLCRPQFLTDRV 265
Cdd:cd18457   81 NREEYLPELLSKVRLPLLRPQFLTDRV 107

PHA03098

kelch-like protein; Provisional

68-530

1.01e-66

kelch-like protein; Provisional

Pssm-ID: 222983 [Multi-domain] Cd Length: 534 Bit Score: 226.57 E-value: 1.01e-66

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569  68 VGDHKFSAHRIVLAASIPYFHAMFTNDMMEckqDEIVMQGmDPSALEALINFAYNGHLAIDQQNVQSLLMGASFLQLQNI 147
Cdd:PHA03098  18 NGGGIIKVHKIILSSSSEYFKKMFKNNFKE---NEINLNI-DYDSFNEVIKYIYTGKINITSNNVKDILSIANYLIIDFL 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569 148 KDACCTFLRERLHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPFEDVLELVSRDELNVKSEEQVFE 227
Cdd:PHA03098  94 INLCINYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYNDPDFIYLSKNELIKILSDDKLNVSSEDVVLE 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569 228 AALAWIRYDRDQRESFLPELLSKIRLPLCRPQFLTD------------RVQQDDLV---RCCHKCRD----LVDEAKDYH 288
Cdd:PHA03098 174 IIIKWLTSKKNNKYKDICLILKVLRITFLSEEGIKKlkrwklrikkkkIVFNKRCIkiiYSKKYNLNkilpRSSTFGSII 253

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569 289 LMPERRPHL------PAFKTR----------PRCCTSIA--GLIYAVGGLNSAGDSLNVVEVFDPIANRWEKCQPMTTAR 350
Cdd:PHA03098 254 YIHITMSIFtynyitNYSPLSeintiidihyVYCFGSVVlnNVIYFIGGMNKNNLSVNSVVSYDTKTKSWNKVPELIYPR 333

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569 351 SRVGVAVVNGLLYAIGGYDGQLRLSTVEVYNPEMDSWSKVESMNSKRSAMGTVVLDGQIYVCGG-YDGNSSLNSVESYSP 429
Cdd:PHA03098 334 KNPGVTVFNNRIYVIGGIYNSISLNTVESWKPGESKWREEPPLIFPRYNPCVVNVNNLIYVIGGiSKNDELLKTVECFSL 413

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569 430 ETNKWTVVTPMSSNRSAAGVTVFEGRIYVSGGH---DGLQIFNSVEYYNHHTATWHPVASMLNKRCRHGAASLGSKMFVC 506
Cdd:PHA03098 414 NTNKWSKGSPLPISHYGGCAIYHDGKIYVIGGIsyiDNIKVYNIVESYNPVTNKWTELSSLNFPRINASLCIFNNKIYVV 493

                        490       500
                 ....*....|....*....|....
gi 686585569 507 GGYDGSGFLSIAEVYSSMADQWYL 530
Cdd:PHA03098 494 GGDKYEYYINEIEVYDDKTNTWTL 517

BTB_POZ_KLHL18

cd18247

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

68-158

6.70e-60

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for a Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349556 [Multi-domain] Cd Length: 116 Bit Score: 194.81 E-value: 6.70e-60

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569  68 VGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGHLAIDQQNVQSLLMGASFLQLQNI 147
Cdd:cd18247   26 VGDQKFSAHRIVLAATIPYFHAMFTHDMVESKQDEITMQGIEPSALEALINFAYSGRIAIDTSNVQSLLVGASFLQLQSV 105

                         90
                 ....*....|.
gi 686585569 148 KDACCTFLRER 158
Cdd:cd18247  106 KDACCEFLKER 116

NanM

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];

340-581

4.97e-59

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];

Pssm-ID: 442289 [Multi-domain] Cd Length: 277 Bit Score: 198.46 E-value: 4.97e-59

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569 340 WEKCQPMTTARSRVGVAVVNGLLYAIGGYDGQLRLSTVEVYNPEMDSWSKVESMNSK-RSAMGTVVLDGQIYVCGGYDGN 418
Cdd:COG3055    3 WSSLPDLPTPRSEAAAALLDGKVYVAGGLSGGSASNSFEVYDPATNTWSELAPLPGPpRHHAAAVAQDGKLYVFGGFTGA 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569 419 ----SSLNSVESYSPETNKWTVVTPMSSNRSAAGVTVFEGRIYVSGGHDGLQIFNSVEYYNHHTATWHPVASMLNKRCRH 494
Cdd:COG3055   83 npssTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPLPTPRDHL 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569 495 GAASLGS-KMFVCGGYDGSGFlsiaevyssmADQWYLIVPMNSRRSRVSLVANCGRLYAVGGYDGQSNlsSVEMYDPETN 573
Cdd:COG3055  163 AAAVLPDgKILVIGGRNGSGF----------SNTWTTLAPLPTARAGHAAAVLGGKILVFGGESGFSD--EVEAYDPATN 230


                 ....*...
gi 686585569 574 RWTFMAPM 581
Cdd:COG3055  231 TWTALGEL 238

BACK

pfam07707

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...

164-266

1.10e-45

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).

Pssm-ID: 462237 [Multi-domain] Cd Length: 103 Bit Score: 156.55 E-value: 1.10e-45

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569  164 CLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPFEDVLELVSRDELNVKSEEQVFEAALAWIRYDRDQRESF 243
Cdd:pfam07707   1 CLGIYRFADAYGCTELAEAALRFILQNFLEVAKSEEFLELSLEQLLELLSSDDLNVPSEEEVFEAVIRWVKHDVERRKKH 80

                          90       100
                  ....*....|....*....|...
gi 686585569  244 LPELLSKIRLPLCRPQFLTDRVQ 266
Cdd:pfam07707  81 LPELLSAVRLPLLSPQYLLNLVE 103

BACK

smart00875

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...

164-264

8.92e-40

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.

Pssm-ID: 197943 [Multi-domain] Cd Length: 101 Bit Score: 140.55 E-value: 8.92e-40

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569   164 CLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPFEDVLELVSRDELNVKSEEQVFEAALAWIRYDRDQRESF 243
Cdd:smart00875   1 CLGIRRFADAHGLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSSDDLNVSSEEEVFEAVLRWVKHDPEKRREH 80

                           90       100
                   ....*....|....*....|.
gi 686585569   244 LPELLSKIRLPLCRPQFLTDR 264
Cdd:smart00875  81 LPELLEHVRLPLLSPDYLLEV 101

BTB

pfam00651

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...

68-159

3.93e-28

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

Pssm-ID: 395526 [Multi-domain] Cd Length: 107 Bit Score: 108.50 E-value: 3.93e-28

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569   68 VGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGHLaIDQQNVQSLLMGASFLQLQNI 147
Cdd:pfam00651  17 VGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEITLDDVSPEDFEALLEFMYTGKL-ISEENVDDLLAAADKLQIPSL 95

                          90
                  ....*....|..
gi 686585569  148 KDACCTFLRERL 159
Cdd:pfam00651  96 VDKCEEFLIKSL 107

BTB

smart00225

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...

67-159

2.67e-27

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

Pssm-ID: 197585 [Multi-domain] Cd Length: 97 Bit Score: 105.85 E-value: 2.67e-27

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569    67 RVGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGHLAIDQQNVQSLLMGASFLQLQN 146
Cdd:smart00225   5 VVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADYLQIPG 84

                           90
                   ....*....|...
gi 686585569   147 IKDACCTFLRERL 159
Cdd:smart00225  85 LVELCEEFLLKLL 97

Kelch_1

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...

537-581

1.11e-13

Pssm-ID: 396078 [Multi-domain] Cd Length: 46 Bit Score: 65.33 E-value: 1.11e-13

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 686585569  537 RRSRVSLVANCGRLYAVGGYDGQSNLSSVEMYDPETNRWTFMAPM 581
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSM 45

Kelch

Kelch domain;

549-590

4.31e-13

Kelch domain;

Pssm-ID: 128874 [Multi-domain] Cd Length: 47 Bit Score: 63.73 E-value: 4.31e-13

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 686585569   549 RLYAVGGYDGQSNLSSVEMYDPETNRWTFMAPMVCHEGGVGV 590
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGV 42

PLN02153

epithiospecifier protein

491-587

4.30e-05

epithiospecifier protein

Pssm-ID: 177814 [Multi-domain] Cd Length: 341 Bit Score: 46.13 E-value: 4.30e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569 491 RCRHGAASLGSKMFVCGGYDGSGFLSIAEVYS-SMADQWYLIVPMNSRRSRVS-----LVANCGRLYAVGGYDGQSNLSS 564
Cdd:PLN02153  23 RCSHGIAVVGDKLYSFGGELKPNEHIDKDLYVfDFNTHTWSIAPANGDVPRISclgvrMVAVGTKLYIFGGRDEKREFSD 102

                         90       100
                 ....*....|....*....|...
gi 686585569 565 VEMYDPETNRWTFMAPMVcHEGG 587
Cdd:PLN02153 103 FYSYDTVKNEWTFLTKLD-EEGG 124

Name

Accession

Description

Interval

E-value

BACK_KLHL18

cd18457

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as ...

159-265

3.07e-76

Pssm-ID: 350532 [Multi-domain] Cd Length: 107 Bit Score: 237.21 E-value: 3.07e-76

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569 159 LHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPFEDVLELVSRDELNVKSEEQVFEAALAWIRYDRD 238
Cdd:cd18457    1 LHPNNCLGIRQFAETMMCSSLVDAANKYIQQHFIEVSKSEEFLALSKEEVLEILSRDELNVKSEEQVFEAALAWVKYDRE 80

                         90       100
                 ....*....|....*....|....*..
gi 686585569 239 QRESFLPELLSKIRLPLCRPQFLTDRV 265
Cdd:cd18457   81 NREEYLPELLSKVRLPLLRPQFLTDRV 107

PHA03098

kelch-like protein; Provisional

68-530

1.01e-66

kelch-like protein; Provisional

Pssm-ID: 222983 [Multi-domain] Cd Length: 534 Bit Score: 226.57 E-value: 1.01e-66

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569  68 VGDHKFSAHRIVLAASIPYFHAMFTNDMMEckqDEIVMQGmDPSALEALINFAYNGHLAIDQQNVQSLLMGASFLQLQNI 147
Cdd:PHA03098  18 NGGGIIKVHKIILSSSSEYFKKMFKNNFKE---NEINLNI-DYDSFNEVIKYIYTGKINITSNNVKDILSIANYLIIDFL 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569 148 KDACCTFLRERLHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPFEDVLELVSRDELNVKSEEQVFE 227
Cdd:PHA03098  94 INLCINYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYNDPDFIYLSKNELIKILSDDKLNVSSEDVVLE 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569 228 AALAWIRYDRDQRESFLPELLSKIRLPLCRPQFLTD------------RVQQDDLV---RCCHKCRD----LVDEAKDYH 288
Cdd:PHA03098 174 IIIKWLTSKKNNKYKDICLILKVLRITFLSEEGIKKlkrwklrikkkkIVFNKRCIkiiYSKKYNLNkilpRSSTFGSII 253

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569 289 LMPERRPHL------PAFKTR----------PRCCTSIA--GLIYAVGGLNSAGDSLNVVEVFDPIANRWEKCQPMTTAR 350
Cdd:PHA03098 254 YIHITMSIFtynyitNYSPLSeintiidihyVYCFGSVVlnNVIYFIGGMNKNNLSVNSVVSYDTKTKSWNKVPELIYPR 333

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569 351 SRVGVAVVNGLLYAIGGYDGQLRLSTVEVYNPEMDSWSKVESMNSKRSAMGTVVLDGQIYVCGG-YDGNSSLNSVESYSP 429
Cdd:PHA03098 334 KNPGVTVFNNRIYVIGGIYNSISLNTVESWKPGESKWREEPPLIFPRYNPCVVNVNNLIYVIGGiSKNDELLKTVECFSL 413

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569 430 ETNKWTVVTPMSSNRSAAGVTVFEGRIYVSGGH---DGLQIFNSVEYYNHHTATWHPVASMLNKRCRHGAASLGSKMFVC 506
Cdd:PHA03098 414 NTNKWSKGSPLPISHYGGCAIYHDGKIYVIGGIsyiDNIKVYNIVESYNPVTNKWTELSSLNFPRINASLCIFNNKIYVV 493

                        490       500
                 ....*....|....*....|....
gi 686585569 507 GGYDGSGFLSIAEVYSSMADQWYL 530
Cdd:PHA03098 494 GGDKYEYYINEIEVYDDKTNTWTL 517

BTB_POZ_KLHL18

cd18247

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

68-158

6.70e-60

Pssm-ID: 349556 [Multi-domain] Cd Length: 116 Bit Score: 194.81 E-value: 6.70e-60

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569  68 VGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGHLAIDQQNVQSLLMGASFLQLQNI 147
Cdd:cd18247   26 VGDQKFSAHRIVLAATIPYFHAMFTHDMVESKQDEITMQGIEPSALEALINFAYSGRIAIDTSNVQSLLVGASFLQLQSV 105

                         90
                 ....*....|.
gi 686585569 148 KDACCTFLRER 158
Cdd:cd18247  106 KDACCEFLKER 116

NanM

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];

340-581

4.97e-59

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];

Pssm-ID: 442289 [Multi-domain] Cd Length: 277 Bit Score: 198.46 E-value: 4.97e-59

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569 340 WEKCQPMTTARSRVGVAVVNGLLYAIGGYDGQLRLSTVEVYNPEMDSWSKVESMNSK-RSAMGTVVLDGQIYVCGGYDGN 418
Cdd:COG3055    3 WSSLPDLPTPRSEAAAALLDGKVYVAGGLSGGSASNSFEVYDPATNTWSELAPLPGPpRHHAAAVAQDGKLYVFGGFTGA 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569 419 ----SSLNSVESYSPETNKWTVVTPMSSNRSAAGVTVFEGRIYVSGGHDGLQIFNSVEYYNHHTATWHPVASMLNKRCRH 494
Cdd:COG3055   83 npssTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPLPTPRDHL 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569 495 GAASLGS-KMFVCGGYDGSGFlsiaevyssmADQWYLIVPMNSRRSRVSLVANCGRLYAVGGYDGQSNlsSVEMYDPETN 573
Cdd:COG3055  163 AAAVLPDgKILVIGGRNGSGF----------SNTWTTLAPLPTARAGHAAAVLGGKILVFGGESGFSD--EVEAYDPATN 230


                 ....*...
gi 686585569 574 RWTFMAPM 581
Cdd:COG3055  231 TWTALGEL 238

NanM

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];

306-569

6.59e-57

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];

Pssm-ID: 442289 [Multi-domain] Cd Length: 277 Bit Score: 192.68 E-value: 6.59e-57

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569 306 CCTSIAGLIYAVGGLnSAGDSLNVVEVFDPIANRWEKCQPM-TTARSRVGVAVVNGLLYAIGGYDGQLR----LSTVEVY 380
Cdd:COG3055   17 AAALLDGKVYVAGGL-SGGSASNSFEVYDPATNTWSELAPLpGPPRHHAAAVAQDGKLYVFGGFTGANPsstpLNDVYVY 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569 381 NPEMDSWSKVESMNSKRSAMGTVVLDGQIYVCGGYDGNSSLNSVESYSPETNKWTVVTPMSSNR-SAAGVTVFEGRIYVS 459
Cdd:COG3055   96 DPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPLPTPRdHLAAAVLPDGKILVI 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569 460 GGHDGlqifnsveyyNHHTATWHPVASMLNKRCRHGAASLGSKMFVCGGYdgSGFLSIAEVYSSMADQWYLIVPMN-SRR 538
Cdd:COG3055  176 GGRNG----------SGFSNTWTTLAPLPTARAGHAAAVLGGKILVFGGE--SGFSDEVEAYDPATNTWTALGELPtPRH 243

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 686585569 539 SRVSLVANcGRLYAVGGYDGQ----SNLSSVEMYD 569
Cdd:COG3055  244 GHAAVLTD-GKVYVIGGETKPgvrtPLVTSAEVYD 277

BACK_KLHL12

cd18452

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also ...

159-294

4.69e-56

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also termed CUL3-interacting protein 1 (C3IP1), or DKIR, is a substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport.

Pssm-ID: 350527 [Multi-domain] Cd Length: 136 Bit Score: 185.68 E-value: 4.69e-56

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569 159 LHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPFEDVLELVSRDELNVKSEEQVFEAALAWIRYDRD 238
Cdd:cd18452    1 LDPSNCLGIRDFAETHNCVDLMQAAEVFSQKHFPEVVQHEEFMLLSQEEVEKLIKSDEIQVDSEEPVFEAVLNWVKHDKE 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 686585569 239 QRESFLPELLSKIRLPLCRPQFLTDRVQQDDLVRCCHKCRDLVDEAKDYHLMPERR 294
Cdd:cd18452   81 EREDYLPELLQYVRLPLLSPRYITDVVDAEPLIRCSLECRDLVDEAKKFHLRPELR 136

BACK_KLHL2_like

cd18445

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL2 and KLHL3; This ...

159-272

1.73e-47

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL2 and KLHL3; This subfamily includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. Both KLHL2 and KLHL3 function as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins.

Pssm-ID: 350520 [Multi-domain] Cd Length: 114 Bit Score: 162.02 E-value: 1.73e-47

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569 159 LHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPFEDVLELVSRDELNVKSEEQVFEAALAWIRYDRD 238
Cdd:cd18445    1 LHPSNCLGIRAFADLHSCTDLLKYAQTYTEQHFSEVVKGEEFLLLSKEQVCELISSDDLTVPSEEKVFEAVMSWVNHDPE 80

                         90       100       110
                 ....*....|....*....|....*....|....
gi 686585569 239 QRESFLPELLSKIRLPLCRPQFLTDRVQQDDLVR 272
Cdd:cd18445   81 NRKEHLAELLEHVRLPLLSPEYLVQRVEEEELIK 114

BACK

pfam07707

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...

164-266

1.10e-45

Pssm-ID: 462237 [Multi-domain] Cd Length: 103 Bit Score: 156.55 E-value: 1.10e-45

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569  164 CLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPFEDVLELVSRDELNVKSEEQVFEAALAWIRYDRDQRESF 243
Cdd:pfam07707   1 CLGIYRFADAYGCTELAEAALRFILQNFLEVAKSEEFLELSLEQLLELLSSDDLNVPSEEEVFEAVIRWVKHDVERRKKH 80

                          90       100
                  ....*....|....*....|...
gi 686585569  244 LPELLSKIRLPLCRPQFLTDRVQ 266
Cdd:pfam07707  81 LPELLSAVRLPLLSPQYLLNLVE 103

NanM

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];

297-522

2.17e-45

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];

Pssm-ID: 442289 [Multi-domain] Cd Length: 277 Bit Score: 161.86 E-value: 2.17e-45

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569 297 LPAFKTRPR---CCTSIAGLIYAVGGLNSAGDS---LNVVEVFDPIANRWEKCQPMTTARSRVGVAVVNGLLYAIGGYDG 370
Cdd:COG3055   53 LAPLPGPPRhhaAAVAQDGKLYVFGGFTGANPSstpLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDD 132

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569 371 QLRLSTVEVYNPEMDSWSKVESMNSKR-SAMGTVVLDGQIYVCGGYDGNSSlnsvesyspeTNKWTVVTPMSSNRSAAGV 449
Cdd:COG3055  133 GGNVAWVEVYDPATGTWTQLAPLPTPRdHLAAAVLPDGKILVIGGRNGSGF----------SNTWTTLAPLPTARAGHAA 202

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 686585569 450 TVFEGRIYVSGGHDGlqIFNSVEYYNHHTATWHPVASMLNKRCRHGAASLGSKMFVCGGYDGSGF----LSIAEVYS 522
Cdd:COG3055  203 AVLGGKILVFGGESG--FSDEVEAYDPATNTWTALGELPTPRHGHAAVLTDGKVYVIGGETKPGVrtplVTSAEVYD 277

BACK_KLHL1_like

cd18444

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; ...

158-263

4.60e-42

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This subfamily contains Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. Members of this subfamily contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels.

Pssm-ID: 350519 [Multi-domain] Cd Length: 106 Bit Score: 147.09 E-value: 4.60e-42

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569 158 RLHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPFEDVLELVSRDELNVKSEEQVFEAALAWIRYDR 237
Cdd:cd18444    1 QLHPSNCLGIRSFADAQGCTDLLKVAHNYTMEHFMEVIQNQEFLLLPAEEVAKLLASDDLNVPSEETIFHALLLWVKHDL 80

                         90       100
                 ....*....|....*....|....*.
gi 686585569 238 DQRESFLPELLSKIRLPLCRPQFLTD 263
Cdd:cd18444   81 PERKKHLAKLLALIRLPLLTPQFLAD 106

BACK_KLHL2_Mayven

cd18512

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also ...

159-288

4.73e-40

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation.

Pssm-ID: 350587 [Multi-domain] Cd Length: 130 Bit Score: 142.48 E-value: 4.73e-40

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569 159 LHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPFEDVLELVSRDELNVKSEEQVFEAALAWIRYDRD 238
Cdd:cd18512    1 LHPTNCLGIRAFADMHACTELLNQANTYAEQHFSDVVLSEEFLNLGIEQVCSLIASDKLTISSEEKVFEAVIAWVNHDKE 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 686585569 239 QRESFLPELLSKIRLPLCRPQFLTDRVQQDDLVRCCHKCRDLVDEAKDYH 288
Cdd:cd18512   81 VRQEHMAHLMEHVRLPLLSREYLVQRVEEETLVKNSSACKDYLIEAMKYH 130

BACK_KLHL3

cd18513

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 3 (KLHL3); KLHL3 serves as ...

159-288

7.98e-40

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 3 (KLHL3); KLHL3 serves as a substrate adapter in Cullin3 (Cul3) E3 ubiquitin ligase complexes. It is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation.

Pssm-ID: 350588 [Multi-domain] Cd Length: 130 Bit Score: 141.74 E-value: 7.98e-40

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569 159 LHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPFEDVLELVSRDELNVKSEEQVFEAALAWIRYDRD 238
Cdd:cd18513    1 LHPTNCLGIRAFADVHTCTELLQQANAYAEQHFPEVMLGEEFLSLSLDQVCSLISSDKLTVSSEEKVFEAVISWIKYDKE 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 686585569 239 QRESFLPELLSKIRLPLCRPQFLTDRVQQDDLVRCCHKCRDLVDEAKDYH 288
Cdd:cd18513   81 ARLEHMAKLMEHVRLPLLPRDYLVQTVEEEALIKNNNTCKDFLIEAMKYH 130

BACK

smart00875

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...

164-264

8.92e-40

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.

Pssm-ID: 197943 [Multi-domain] Cd Length: 101 Bit Score: 140.55 E-value: 8.92e-40

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569   164 CLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPFEDVLELVSRDELNVKSEEQVFEAALAWIRYDRDQRESF 243
Cdd:smart00875   1 CLGIRRFADAHGLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSSDDLNVSSEEEVFEAVLRWVKHDPEKRREH 80

                           90       100
                   ....*....|....*....|.
gi 686585569   244 LPELLSKIRLPLCRPQFLTDR 264
Cdd:smart00875  81 LPELLEHVRLPLLSPDYLLEV 101

BTB_POZ_KLHL8

cd18238

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

67-166

1.08e-37

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349547 [Multi-domain] Cd Length: 120 Bit Score: 135.50 E-value: 1.08e-37

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569  67 RVGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGHLAIDQQNVQSLLMGASFLQLQN 146
Cdd:cd18238   21 KVGEKSIHCHRLVLACVSPYFRAMFTSEMAESKQDSITIKDIDEEAVELLVDFAYTGKLTLTVDNVQSLLYAASLLQVEE 100

                         90       100
                 ....*....|....*....|
gi 686585569 147 IKDACCTFLRERLHPKNCLG 166
Cdd:cd18238  101 VAKACCEFMKDHLHPSNCLG 120

BTB_POZ_KLHL1-like

cd18234

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

68-165

1.30e-37

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This family contains the Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. Family members contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349543 [Multi-domain] Cd Length: 105 Bit Score: 134.80 E-value: 1.30e-37

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569  68 VGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGHLAIDQQNVQSLLMGASFLQLQNI 147
Cdd:cd18234    8 AGDRRIPAHRLVLSAVSDYFAAMFTNDVREATEEEIKLKDVDPDALWTLVQYCYTGRLELKEDNVESLLATACLLQLSEV 87

                         90
                 ....*....|....*...
gi 686585569 148 KDACCTFLRERLHPKNCL 165
Cdd:cd18234   88 VEACCGFLMKQLHPSNCL 105

BTB_POZ_KLHL4

cd18336

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

69-168

1.78e-35

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It may be associated with X-linked cleft palate (CPX) and is also a candidate gene in the impairment of mullerian duct development. In addition, it has been identified as a target of insulin-like growth factor binding protein 5 (IGFBP5). KLHL4 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349645 [Multi-domain] Cd Length: 126 Bit Score: 129.78 E-value: 1.78e-35

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569  69 GDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGHLAIDQQNVQSLLMGASFLQLQNIK 148
Cdd:cd18336   27 GNLKIPAHRLVLSAVSDYFAAMFTNDVREAKQEEIKMEGVDPDALKALVHYAYTGVLELKEDTIESLLAAACLLQLSQVI 106

                         90       100
                 ....*....|....*....|
gi 686585569 149 DACCTFLRERLHPKNCLGVR 168
Cdd:cd18336  107 DVCCNFLMKQLHPSNCLGIR 126

BTB_POZ_KLHL27_IPP

cd18256

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

68-166

3.53e-34

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349565 [Multi-domain] Cd Length: 125 Bit Score: 125.98 E-value: 3.53e-34

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569  68 VGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGHLAIDQQNVQSLLMGASFLQLQNI 147
Cdd:cd18256   27 VGMELFSVHRLVLAASSPYFAALFAGGMSESSKDVVQIHGVEPDIFHILLDFIYTGVVEVTVSNVQELLVAADMLQLTEV 106

                         90
                 ....*....|....*....
gi 686585569 148 KDACCTFLRERLHPKNCLG 166
Cdd:cd18256  107 VEICCEFLKGQLHPSNCIG 125

BTB_POZ_KLHL2-like

cd18235

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

68-161

4.93e-33

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL2 and KLHL3; The family includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 and KLHL3 each functions as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins. They contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349544 [Multi-domain] Cd Length: 121 Bit Score: 122.54 E-value: 4.93e-33

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569  68 VGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGHLAIDQQNVQSLLMGASFLQLQNI 147
Cdd:cd18235   28 ADGVEIPAHRVVLASCSPYFHAMFTGDLSESRANRVTLQDVDGKALLLLIDYVYTAEIQVTEENVQVLLPAANLLQLTDV 107

                         90
                 ....*....|....
gi 686585569 148 KDACCTFLRERLHP 161
Cdd:cd18235  108 RDACCDFLQSQLHP 121

BTB_POZ_KLHL20_KLEIP

cd18249

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

68-166

5.20e-33

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also called Kelch-like ECT2-interacting protein (KLEIP) or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349558 [Multi-domain] Cd Length: 128 Bit Score: 122.95 E-value: 5.20e-33

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569  68 VGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGHLAIDQQNVQSLLMGASFLQLQNI 147
Cdd:cd18249   30 VGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVTIRDIDERAMELLIDFAYTSQITVEEGNVQTLLPAACLLQLAEI 109

                         90
                 ....*....|....*....
gi 686585569 148 KDACCTFLRERLHPKNCLG 166
Cdd:cd18249  110 QEVCCEFLKRQLDPSNCLG 128

BTB_POZ_KLHL7

cd18237

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

68-166

6.64e-33

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349546 [Multi-domain] Cd Length: 126 Bit Score: 122.60 E-value: 6.64e-33

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569  68 VGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGHLAIDQQNVQSLLMGASFLQLQNI 147
Cdd:cd18237   28 VEGREIKAHRVVLAAASHFFHLMFTSNMTESKSSEVELKDAEPDIIELLVEFAYTARISVNSNNVQSLLDAANQYQIEPV 107

                         90
                 ....*....|....*....
gi 686585569 148 KDACCTFLRERLHPKNCLG 166
Cdd:cd18237  108 KKMCVDFLKEQLDASNCLG 126

BACK_KLHL5

cd18511

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares ...

158-263

1.27e-32

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. It is abundantly expressed in ovary, adrenal gland, and thymus.

Pssm-ID: 350586 [Multi-domain] Cd Length: 106 Bit Score: 120.94 E-value: 1.27e-32

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569 158 RLHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPFEDVLELVSRDELNVKSEEQVFEAALAWIRYDR 237
Cdd:cd18511    1 QLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFLLLPASEIAKLLASDDMNIPNEETILNALLSWVRHDV 80

                         90       100
                 ....*....|....*....|....*.
gi 686585569 238 DQRESFLPELLSKIRLPLCRPQFLTD 263
Cdd:cd18511   81 EQRRKDLSKLLAYIRLPLLAPQFLAD 106

BACK_KLHL1

cd18509

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a ...

159-263

4.07e-32

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. It may play a role in organizing the actin cytoskeleton in brain cells. KLHL1 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein.

Pssm-ID: 350584 [Multi-domain] Cd Length: 106 Bit Score: 119.74 E-value: 4.07e-32

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569 159 LHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPFEDVLELVSRDELNVKSEEQVFEAALAWIRYDRD 238
Cdd:cd18509    2 LHPSNCLGIRAFADAQGCIELMKVAHSYTMENIMEVIRNQEFLLLPAEELHKLLASDDVNVPDEETIFHALMMWVKYDMQ 81

                         90       100
                 ....*....|....*....|....*
gi 686585569 239 QRESFLPELLSKIRLPLCRPQFLTD 263
Cdd:cd18509   82 RRCSDLSMLLAYIRLPLLPPQLLAD 106

BTB_POZ_KLHL28_BTBD5

cd18257

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

67-161

1.81e-31

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also called BTB/POZ domain-containing protein 5 (BTBD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349566 [Multi-domain] Cd Length: 118 Bit Score: 118.41 E-value: 1.81e-31

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569  67 RVGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGHLAIDQQNVQSLLMGASFLQLQN 146
Cdd:cd18257   24 RVGDVKIHAHKVVLASCSPYFKAMFTGNLSEKENSEVEFQCIDETALQAIVEYAYTGTVFISQATVESLLPAANLLQIKL 103

                         90
                 ....*....|....*
gi 686585569 147 IKDACCTFLRERLHP 161
Cdd:cd18257  104 VLKECCDFLESQLDP 118

BACK_KLHL20

cd18459

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also ...

158-256

2.17e-30

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also termed Kelch-like ECT2-interacting protein (KLEIP), or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis.

Pssm-ID: 350534 [Multi-domain] Cd Length: 100 Bit Score: 114.45 E-value: 2.17e-30

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569 158 RLHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPFEDVLELVSRDELNVKSEEQVFEAALAWIRYDR 237
Cdd:cd18459    1 QLDPSNCLGIRAFADTHACRELLRIADKFTQHNFQEVMESEEFMLLPVNQLIDIISSDELNVRSEEQVFNAVMAWVKYNI 80

                         90
                 ....*....|....*....
gi 686585569 238 DQRESFLPELLSKIRLPLC 256
Cdd:cd18459   81 QERRPHLPQVLQHVRLPLL 99

BACK_KLHL8

cd18448

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a ...

158-254

3.44e-30

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex. The BCR(KLHL8) ubiquitin ligase complex mediates ubiquitination and degradation of RAPSN.

Pssm-ID: 350523 [Multi-domain] Cd Length: 97 Bit Score: 113.94 E-value: 3.44e-30

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569 158 RLHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPFEDVLELVSRDELNVKSEEQVFEAALAWIRYDR 237
Cdd:cd18448    1 HLHPSNCLGVRTFAEQHNRVDLMKMADKYACDHFNEVVECEEFVSISAQHLEKLISSSDLNVESESQVYEAVMKWVKHDP 80

                         90
                 ....*....|....*..
gi 686585569 238 DQRESFLPELLSKIRLP 254
Cdd:cd18448   81 QHRKRHLDDLLSQVRLP 97

BTB_POZ_KLHL12_C3IP1_DKIR

cd18242

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

67-164

3.56e-30

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349551 [Multi-domain] Cd Length: 124 Bit Score: 114.85 E-value: 3.56e-30

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569  67 RVGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGHLAIDQQNVQSLLMGASFLQLQN 146
Cdd:cd18242   27 RVEGKEFPAHRIVLAACSDYFCAMFTSEMSEKGKSEVELQGLTASTMEILLDFVYTETVHVTVENVQELLPAACLLQLKG 106

                         90
                 ....*....|....*...
gi 686585569 147 IKDACCTFLRERLHPKNC 164
Cdd:cd18242  107 VKQACCEFLESQLDPSNC 124

BACK_KLHL4

cd18510

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares ...

158-263

1.42e-29

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein.

Pssm-ID: 350585 [Multi-domain] Cd Length: 106 Bit Score: 112.32 E-value: 1.42e-29

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569 158 RLHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPFEDVLELVSRDELNVKSEEQVFEAALAWIRYDR 237
Cdd:cd18510    1 QLHPSNCLGIRSFGDAQGCTELLKVAHSYTMEHFLEVIKNQEFLLLPASEIVKLLASDDINVPDEETIFQALMMWVRHDL 80

                         90       100
                 ....*....|....*....|....*.
gi 686585569 238 DQRESFLPELLSKIRLPLCRPQFLTD 263
Cdd:cd18510   81 QNRQKDLGMLLSYIRLPLLPPQLLAD 106

BTB_POZ_KLHL1

cd18335

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

68-168

1.91e-29

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. It may play a role in organizing the actin cytoskeleton the brain cells. KLHL1 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349644 [Multi-domain] Cd Length: 126 Bit Score: 112.83 E-value: 1.91e-29

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569  68 VGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGHLAIDQQNVQSLLMGASFLQLQNI 147
Cdd:cd18335   26 AGNRKIPAHRLVLSAVSDYFAAMFTSDVCEAKQEEIKMEGIDPNALWDLVQFAYTGCLELKEDTIENLLAAACLLQLSQV 105

                         90       100
                 ....*....|....*....|.
gi 686585569 148 KDACCTFLRERLHPKNCLGVR 168
Cdd:cd18335  106 VEVCCHFLMKLLHPSNCLGIR 126

BTB_POZ_KLHL5

cd18337

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

69-168

3.91e-29

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It is abundantly expressed in the ovary, adrenal gland, and thymus. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349646 [Multi-domain] Cd Length: 130 Bit Score: 112.08 E-value: 3.91e-29

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569  69 GDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGHLAIDQQNVQSLLMGASFLQLQNIK 148
Cdd:cd18337   31 GDRRIPAHRLVLSSVSDYFAAMFTNDVREAKQEEIKMEGVEPNALWALVQYAYTGRLELKEDNIECLLSTACLLQLSQVV 110

                         90       100
                 ....*....|....*....|
gi 686585569 149 DACCTFLRERLHPKNCLGVR 168
Cdd:cd18337  111 EACCKFLMKQLHPSNCLGIR 130

BACK_KLHL17

cd18456

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also ...

159-260

4.61e-29

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also termed actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GluR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in the actin-based neuronal function.

Pssm-ID: 350531 [Multi-domain] Cd Length: 102 Bit Score: 110.86 E-value: 4.61e-29

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569 159 LHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPFEDVLELVSRDELNVKSEEQVFEAALAWIRYDRD 238
Cdd:cd18456    1 LDPSNCLGIRGFADTHSCSDLLKSAHKYVLQHFVEVSKTEEFMLLPLKQVLDLISSDSLNVPSEEEVYRAVLSWVKHDVD 80

                         90       100
                 ....*....|....*....|..
gi 686585569 239 QRESFLPELLSKIRLPLCRPQF 260
Cdd:cd18456   81 GRRQHVPRLMKCVRLPLLSRDF 102

BACK_KLHL16_gigaxonin

cd18455

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 16 (KLHL16); Gigaxonin, ...

161-252

8.30e-29

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 16 (KLHL16); Gigaxonin, also termed Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy.

Pssm-ID: 350530 [Multi-domain] Cd Length: 97 Bit Score: 110.10 E-value: 8.30e-29

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569 161 PKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPFEDVLELVSRDELNVKSEEQVFEAALAWIRYDRDQR 240
Cdd:cd18455    2 AENCIGIRDFAERFSCPHVHYVATEYLETHFRDVSSTEEFLELSPEKLKELLSRDKLNVGNEEYIFEAVLRWVRHDPEER 81

                         90
                 ....*....|..
gi 686585569 241 ESFLPELLSKIR 252
Cdd:cd18455   82 KVHLKDLMSSCW 93

BACK_KLHL29_KBTBD9

cd18468

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 29 (KLHL29); KLHL29, also ...

160-261

8.81e-29

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 29 (KLHL29); KLHL29, also termed Kelch repeat and BTB domain-containing protein 9 (KBTBD9), belongs to the KLHL family. Its function remains unclear. A nuclear receptor subfamily 5, group A, member 2 (NR5A2)-Kelch-like family member 29 (KLHL29) fusion transcript may participate in the origin or progression of some colon cancers.

Pssm-ID: 350543 [Multi-domain] Cd Length: 102 Bit Score: 110.20 E-value: 8.81e-29

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569 160 HPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPFEDVLELVSRDELNVKSEEQVFEAALAWIRYDRDQ 239
Cdd:cd18468    1 TPSNCLGIWALAEALQCTELHNMAKAYALQNFPDVARQEEILSISKDDIVEYLSHDSLNTKAEELVFETAIKWLKKDPKN 80

                         90       100
                 ....*....|....*....|..
gi 686585569 240 RESFLPELLSKIRLPLCRPQFL 261
Cdd:cd18468   81 RKQHIAELLAVVRLPFIHPSYL 102

BACK_KLHL19_KEAP1

cd18458

BACK (BTB and C-terminal Kelch) domain found in Kelch-like ECH-associated protein 1 (KEAP1); ...

159-248

1.59e-28

BACK (BTB and C-terminal Kelch) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also termed cytosolic inhibitor of Nrf2 (INrf2), or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression.

Pssm-ID: 350533 [Multi-domain] Cd Length: 91 Bit Score: 108.92 E-value: 1.59e-28

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569 159 LHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPFEDVLELVSRDELNVKSEEQVFEAALAWIRYDRD 238
Cdd:cd18458    2 LDPSNCIGIANFAEQHGCTELHKKAREYIYMHFSEVSQSEEFFNLSPCQLVALISRDELNVRCESEVYNAVIRWVKYDEE 81

                         90
                 ....*....|
gi 686585569 239 QRESFLPELL 248
Cdd:cd18458   82 NRRQYLEALL 91

BTB

pfam00651

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...

68-159

3.93e-28

Pssm-ID: 395526 [Multi-domain] Cd Length: 107 Bit Score: 108.50 E-value: 3.93e-28

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569   68 VGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGHLaIDQQNVQSLLMGASFLQLQNI 147
Cdd:pfam00651  17 VGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEITLDDVSPEDFEALLEFMYTGKL-ISEENVDDLLAAADKLQIPSL 95

                          90
                  ....*....|..
gi 686585569  148 KDACCTFLRERL 159
Cdd:pfam00651  96 VDKCEEFLIKSL 107

BACK_KLHL28_BTBD5

cd18467

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also ...

159-255

9.37e-28

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also termed BTB/POZ domain-containing protein 5 (BTBD5), belongs to the KLHL family. Its function remains unclear.

Pssm-ID: 350542 [Multi-domain] Cd Length: 99 Bit Score: 106.95 E-value: 9.37e-28

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569 159 LHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPFEDVLELVSRDELNVKSEEQVFEAALAWIRYDRD 238
Cdd:cd18467    1 LDPGNCIGISRFAETYGCHDLYLAANKYICQNFEDVCQTEEFFELTHAELDEIVSNDCLNVVTEETVFYALESWIKYDVQ 80

                         90
                 ....*....|....*..
gi 686585569 239 QRESFLPELLSKIRLPL 255
Cdd:cd18467   81 ERQKYLAQLLHCVRLPL 97

BTB

smart00225

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...

67-159

2.67e-27

Pssm-ID: 197585 [Multi-domain] Cd Length: 97 Bit Score: 105.85 E-value: 2.67e-27

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569    67 RVGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGHLAIDQQNVQSLLMGASFLQLQN 146
Cdd:smart00225   5 VVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADYLQIPG 84

                           90
                   ....*....|...
gi 686585569   147 IKDACCTFLRERL 159
Cdd:smart00225  85 LVELCEEFLLKLL 97

BTB_POZ_ZBTB_KLHL-like

cd18186

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

67-142

1.60e-26

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349497 [Multi-domain] Cd Length: 82 Bit Score: 103.02 E-value: 1.60e-26

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 686585569  67 RVGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGHLAIDQQNVQSLLMGASFL 142
Cdd:cd18186    7 VVGGREFPAHRAVLAARSPYFRAMFSSGMKESSSSEIELDDVSPEAFEALLDYIYTGELELSEENVEELLAAADKL 82

BTB_POZ_KLHL17_actinfilin

cd18246

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

68-161

2.32e-26

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also called actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GLUR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in actin-based neuronal function. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349555 [Multi-domain] Cd Length: 139 Bit Score: 104.73 E-value: 2.32e-26

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569  68 VGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGHLAIDQQNVQSLLMGASFLQLQNI 147
Cdd:cd18246   46 VGTKEIKAHKVVLASCSPYFHAMFTNEMSESRQTHVTLHDIDPQALEQLVQYAYTAEIVVGEGNVQTLLPAASLLQLNGV 125

                         90
                 ....*....|....
gi 686585569 148 KDACCTFLRERLHP 161
Cdd:cd18246  126 RDACCKFLLSQLDP 139

BTB_POZ_KLHL25

cd18254

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

69-166

4.75e-26

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that is required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). Cullin3-KLHL25 ubiquitin ligase also targets ATP-citrate lyase (ACLY), a key enzyme for lipid synthesis, for degradation to inhibit lipid synthesis and tumor progression. KLHL25 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349563 [Multi-domain] Cd Length: 128 Bit Score: 103.17 E-value: 4.75e-26

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569  69 GDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQ-GMDPSALEALINFAYNGHLAIDQQNVQSLLMGASFLQLQNI 147
Cdd:cd18254   30 GNRSFPCHRAVLAACSRYFEAMFSNGLRESLDSTVNFHdSLHPEVLELLLDFAYSSRIIINEENAESLLEAGDMLQFHDV 109

                         90
                 ....*....|....*....
gi 686585569 148 KDACCTFLRERLHPKNCLG 166
Cdd:cd18254  110 RDAAAEFLEKNLYPSNCLG 128

BACK_KLHL6

cd18446

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a ...

159-266

5.48e-26

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation.

Pssm-ID: 350521 [Multi-domain] Cd Length: 108 Bit Score: 102.55 E-value: 5.48e-26

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569 159 LHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPFEDVLELVSRDELNVKSEEQVFEAALAWIRYDRD 238
Cdd:cd18446    1 LHPENCVGILRLADAHSLESLKKQVQNYIIQNFSQVLNHEEFLELPVDILCHILKSDDLYVTEEEQVFETVMRWVRYKES 80

                         90       100
                 ....*....|....*....|....*...
gi 686585569 239 QRESFLPELLSKIRLPLCRPQFLTDRVQ 266
Cdd:cd18446   81 ERLPLLPRVLENVRLPLLDPWYFVETVE 108

BTB_POZ_KLHL2_Mayven

cd18338

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

70-161

1.00e-25

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349647 [Multi-domain] Cd Length: 121 Bit Score: 102.07 E-value: 1.00e-25

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569  70 DHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGHLAIDQQNVQSLLMGASFLQLQNIKD 149
Cdd:cd18338   30 DVEIAAHRVVLAACSPYFHAMFTGEMSESRAKRVRIKEVDGWTLKMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKK 109

                         90
                 ....*....|..
gi 686585569 150 ACCTFLRERLHP 161
Cdd:cd18338  110 TCCEFLESQLHP 121

BACK_KLHL7

cd18447

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a ...

163-255

1.40e-25

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a BTB-Kelch protein that constitutes a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 cause autosomal-dominant retinitis pigmentosa.

Pssm-ID: 350522 [Multi-domain] Cd Length: 98 Bit Score: 100.90 E-value: 1.40e-25

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569 163 NCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPFEDVLELVSRDELNVKSEEQVFEAALAWIRYDRDQRES 242
Cdd:cd18447    6 NCLGISVLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRWLKYDEPNRQP 85

                         90
                 ....*....|...
gi 686585569 243 FLPELLSKIRLPL 255
Cdd:cd18447   86 YMVDILAKVRFPL 98

BTB_POZ_KLHL6

cd18236

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

68-166

1.68e-25

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349545 [Multi-domain] Cd Length: 129 Bit Score: 101.85 E-value: 1.68e-25

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569  68 VGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGHLAIDQQNVQSLLMGASFLQLQNI 147
Cdd:cd18236   31 VDSQEFSCHRVVLAAASNYFRAMFCNDLKEKYEEKIIIKGVDAETMQILLDYTYTSKVLITKQNVQRVLEAASLFQFLRM 110

                         90
                 ....*....|....*....
gi 686585569 148 KDACCTFLRERLHPKNCLG 166
Cdd:cd18236  111 VDACASFLTEALHPENCVG 129

BTB_POZ_KBTBD6_7

cd18273

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

73-167

5.30e-25

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing proteins KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349582 [Multi-domain] Cd Length: 142 Bit Score: 100.67 E-value: 5.30e-25

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569  73 FSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGHLAIDQQNVQSLLMGASFLQLQNIKDACC 152
Cdd:cd18273   46 FPCNRNVLAAASPYFKSMFTGGLYESKQETVTIHDVDSESMALIIDYCYTGRVTLSEANVQRLYAAANMLQLEYVREACA 125

                         90
                 ....*....|....*
gi 686585569 153 TFLRERLHPKNCLGV 167
Cdd:cd18273  126 SFLARRLDLSNCVGI 140

BTB_POZ_KLHL19_KEAP1

cd18248

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

70-159

5.59e-25

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also called cytosolic inhibitor of Nrf2 (INrf2) or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349557 [Multi-domain] Cd Length: 124 Bit Score: 100.15 E-value: 5.59e-25

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569  70 DHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGHLAIDQQNVQSLLMGASFLQLQNIKD 149
Cdd:cd18248   34 KEEFMAHKVVLASSSPYFKAMFTSGLRECGMEVVPIEGVHPCVMSRLIEFAYTASISVGEKCVLHVLPGAVMYQMDSVVK 113

                         90
                 ....*....|
gi 686585569 150 ACCTFLRERL 159
Cdd:cd18248  114 ACCDFLEQQL 123

BACK_KLHL10

cd18450

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 10 (KLHL10); KLHL10 may be ...

159-236

7.76e-25

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 10 (KLHL10); KLHL10 may be a substrate-specific adapter of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins during spermatogenesis.

Pssm-ID: 350525 [Multi-domain] Cd Length: 80 Bit Score: 98.07 E-value: 7.76e-25

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 686585569 159 LHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSM-SEEFLALPFEDVLELVSRDELNVKSEEQVFEAALAWIRYD 236
Cdd:cd18450    1 LTPENCIGIRKFARYYFCPELERKAYRYILRNFEEVAKdSEEFLELSCEELEDIIEDDELNVKEEEVVFEAIVKWIDHD 79

BACK_KEL_like

cd18508

BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster ring canal kelch ...

163-236

1.42e-24

BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster ring canal kelch protein (KEL) and similar proteins; KEL, also termed kelch short protein, is a component of ring canals that regulates the flow of cytoplasm between cells. It binds actin and may be involved in the regulation of cytoplasm flow from nurse cells to the oocyte during oogenesis.

Pssm-ID: 350583 [Multi-domain] Cd Length: 77 Bit Score: 97.48 E-value: 1.42e-24

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 686585569 163 NCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPFEDVLELVSRDELNVKSEEQVFEAALAWIRYD 236
Cdd:cd18508    4 NCLGIHEFADAHSCVELEEAAQNYIYQHFNEVIQGEEFLSLDHESLTELISSDRLNVPSEERVYEAAVAWLKHD 77

BTB_POZ_KLHL3

cd18339

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

70-161

1.46e-24

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 3 (KLHL3); KLHL3 is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349648 [Multi-domain] Cd Length: 121 Bit Score: 99.03 E-value: 1.46e-24

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569  70 DHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGHLAIDQQNVQSLLMGASFLQLQNIKD 149
Cdd:cd18339   30 DVEIEAHRVVLAACSPYFCAMFTGDMSESKAKKIEIKDVDGQTLSKLIDYIYTAEIEVTEENVQVLLPAASLLQLMDVRQ 109

                         90
                 ....*....|..
gi 686585569 150 ACCTFLRERLHP 161
Cdd:cd18339  110 NCCDFLQSQLHP 121

BTB_POZ_NS1BP

cd18306

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

68-167

1.63e-24

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349615 [Multi-domain] Cd Length: 124 Bit Score: 98.87 E-value: 1.63e-24

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569  68 VGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGHLAIDQQNVQSLLMGASFLQLQNI 147
Cdd:cd18306   25 VGGHEIPAHRAVLACASPYLFELFSSDSDGESILTVKLDGLDPDAVEVLVNYAYTSRLEVPADLVKSVYSAAKKLKMDRV 104

                         90       100
                 ....*....|....*....|
gi 686585569 148 KDACCTFLRERLHPKNCLGV 167
Cdd:cd18306  105 KKACGDFLLEKLTPQNCIGI 124

BTB_POZ_KLHL38

cd18268

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

69-167

2.18e-24

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 38 (KLHL38); KLHL38 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The KLHL38 gene is significantly up-regulated during diapause, a temporary arrest of development during early ontogeny. It may also function in preadipocyte differentiation in the chicken. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349577 [Multi-domain] Cd Length: 129 Bit Score: 98.70 E-value: 2.18e-24

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569  69 GDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGHLAIDQQNVQSLLMGASFLQLQNIK 148
Cdd:cd18268   31 GDKEIPCHRNVLASSSPYFRAMFCNNFRESSQAKVDLKGIDSDVLDQIVDYVYTGEILITRDNVLPLMEAASMLQYPKLF 110

                         90
                 ....*....|....*....
gi 686585569 149 DACCTFLRERLHPKNCLGV 167
Cdd:cd18268  111 EACSLYLQDQLTPENCLSM 129

BTB_POZ_KLHL37_ENC1

cd18267

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

62-167

5.01e-24

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ectoderm-neural cortex protein 1 (ENC-1); ENC-1 is also called Kelch-like protein 37 (KLHL37), nuclear matrix protein NRP/B, or p53-induced gene 10 protein. It is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349576 [Multi-domain] Cd Length: 147 Bit Score: 98.14 E-value: 5.01e-24

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569  62 VHTGNRvgdhKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQ-GMDPSALEALINFAYNGHLAIDQQNVQSLLMGAS 140
Cdd:cd18267   45 LHAGNR----SFPCHRAVLAACSRYFEAMFSGGLKESQDSEVNFHdSIHPEVLELLLDYAYSSRVIINEENAESLLEAGD 120

                         90       100
                 ....*....|....*....|....*..
gi 686585569 141 FLQLQNIKDACCTFLRERLHPKNCLGV 167
Cdd:cd18267  121 MLEFQDIRDACAEFLEKNLHPTNCLGM 147

BTB_POZ_KLHL21

cd18250

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

68-164

5.04e-24

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349559 [Multi-domain] Cd Length: 124 Bit Score: 97.53 E-value: 5.04e-24

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569  68 VGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGHLAIDQQNVQSLLMGASFLQLQNI 147
Cdd:cd18250   28 AGGREFPCHRTVLAAASSYFRAMFAGELRESRADRVVLHGVSAEILGLLLDFSYTGRVTVTQDNVEALLRAADLFQFPSV 107

                         90
                 ....*....|....*..
gi 686585569 148 KDACCTFLRERLHPKNC 164
Cdd:cd18250  108 KEACCAYLQQRLDVSNC 124

BTB_POZ_KLHL10

cd18240

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

67-164

6.42e-24

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 10 (KLHL10); KLHL10 is a substrate-specific adaptor of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins specifically in the testis during spermatogenesis. Haploinsufficiency of Klhl10 causes infertility in male mice. KLHL10 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349549 [Multi-domain] Cd Length: 120 Bit Score: 97.01 E-value: 6.42e-24

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569  67 RVGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGHLAIDQQNVQSLLMGASFLQLQN 146
Cdd:cd18240   23 RVNGVEFPAHRNILCACSPYFRALFTNGWNETEKKVYKIPGVSPEMMELIIEYAYTRTVPITAENVEELLPAADQFNIMG 102

                         90
                 ....*....|....*...
gi 686585569 147 IKDACCTFLRERLHPKNC 164
Cdd:cd18240  103 IVKACCDFLEDQLCPENC 120

BTB_POZ_KLHL30

cd18259

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

68-166

1.31e-23

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 30 (KLHL30); KLHL30 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349568 [Multi-domain] Cd Length: 137 Bit Score: 96.82 E-value: 1.31e-23

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569  68 VGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGHLAIDQQNVQSLLMGASFLQLQNI 147
Cdd:cd18259   39 VGGREFPCHRSVLALCSHYFNAMFTGDFVESISARVEIKDVDPAVMESLIDFAYTGKLTINQGNVEALIRTSNRLQFPTV 118

                         90
                 ....*....|....*....
gi 686585569 148 KDACCTFLRERLHPKNCLG 166
Cdd:cd18259  119 RKVCSRYLQQQIDATNCLG 137

BACK_KLHL27_IPP

cd18466

BACK (BTB and C-terminal Kelch) domain found in intracisternal A particle-promoted polypeptide ...

161-261

1.42e-23

BACK (BTB and C-terminal Kelch) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also termed Kelch-like protein 27 (KLHL27), is an actin-binding protein that may play a role in organizing the actin cytoskeleton.

Pssm-ID: 350541 [Multi-domain] Cd Length: 103 Bit Score: 95.24 E-value: 1.42e-23

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569 161 PKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPFEDVLELVSRDELNVKSEEQVFEAALAWIRYDRDQR 240
Cdd:cd18466    3 PANCIGIFQFSEQIACHDLLEFTENYIHVHFLEVQSGEEFLGLTKDQLVKILRSEELSIEDEYQVFTAAMEWILKDVGKR 82

                         90       100
                 ....*....|....*....|.
gi 686585569 241 ESFLPELLSKIRLPLCRPQFL 261
Cdd:cd18466   83 KKHVVEVLEPVRFPLLPPQRL 103

BTB_POZ_KLHL40_KBTBD5

cd18340

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

67-167

1.92e-23

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5 (KBTBD5) or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy. KLHL40 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349649 [Multi-domain] Cd Length: 134 Bit Score: 96.06 E-value: 1.92e-23

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569  67 RVGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGHLAIDQQNVQSLLMGASFLQLQN 146
Cdd:cd18340   33 KIKEKEFPCHRLVLAACSPYFRAMFLSDLEESKKREIVLEDVDPDVMGKILHYIYTSEIEITEQNVQDIFAAANMFQIPS 112

                         90       100
                 ....*....|....*....|.
gi 686585569 147 IKDACCTFLRERLHPKNCLGV 167
Cdd:cd18340  113 IFTVCVSFLQKRLCLSNCLAI 133

BTB_POZ_KLHL40-like

cd18269

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

67-167

2.30e-23

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL40 and KLHL41; This family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349578 [Multi-domain] Cd Length: 133 Bit Score: 95.94 E-value: 2.30e-23

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569  67 RVGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGHLAIDQQNVQSLLMGASFLQLQN 146
Cdd:cd18269   33 KIGDKEFPCHRLVLAACSPYFRAMFLSDLEESKKKEVVLEDVDPDVMGMILKYLYTSEIDLNDQNVQDIFALASRFQIPS 112

                         90       100
                 ....*....|....*....|.
gi 686585569 147 IKDACCTFLRERLHPKNCLGV 167
Cdd:cd18269  113 IFTVCVSYLQKRLSLSNCLAI 133

BTB_POZ_KBTBD8

cd18274

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

70-167

2.54e-23

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8); KBTBD8, also called T-cell activation kelch repeat protein (TA-KRP), is a BTB-kelch family protein that is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis. It acts as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex monoubiquitylates NOLC1 and its paralog TCOF1, the mutation of which underlies the neurocristopathy Treacher Collins syndrome. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349583 [Multi-domain] Cd Length: 129 Bit Score: 95.82 E-value: 2.54e-23

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569  70 DH--KFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGHLAIDQQNVQSLLMGASFLQLQNI 147
Cdd:cd18274   30 DHgkTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAESMHLVLDYAYTSRVTLTEANVQALFTAASIFQIPSL 109

                         90       100
                 ....*....|....*....|
gi 686585569 148 KDACCTFLRERLHPKNCLGV 167
Cdd:cd18274  110 QDQCAQFMISRLDPQNSIGV 129

BTB_POZ_KBTBD12

cd18276

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

71-167

4.83e-23

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 12 (KBTBD12); KBTBD12, also called Kelch domain-containing protein 6 (KLHDC6), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349585 [Multi-domain] Cd Length: 127 Bit Score: 94.87 E-value: 4.83e-23

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569  71 HKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGHLAIDQQNVQSLLMGASFLQLQNIKDA 150
Cdd:cd18276   31 EKFPCHRLVLAAFSPYFKAMFTCGLMECSQREVVLHDITAESVSIILNYMYSSDLHLTNSNVQGVATAAFFLQMEDIFSV 110

                         90
                 ....*....|....*..
gi 686585569 151 CCTFLRERLHPKNCLGV 167
Cdd:cd18276  111 CQKYMMDHMDASNCLGI 127

BTB_POZ_KLHL26

cd18255

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

68-164

5.70e-23

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is encoded by the klhl26 gene, which is regulated by p53 via fuzzy tandem repeats. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349564 [Multi-domain] Cd Length: 121 Bit Score: 94.38 E-value: 5.70e-23

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569  68 VGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGHLAIDQQNVQSLLMGASFLQLQNI 147
Cdd:cd18255   25 ADGQRFQAHKVVLASCSDYFRAMFTGGMRESSQDEIELKGVSAKGLKHILDFAYTSELTLDLDCIQDVLGAAVHLQMLPV 104

                         90
                 ....*....|....*..
gi 686585569 148 KDACCTFLRERLHPKNC 164
Cdd:cd18255  105 VELCEEFLKSAMSVENC 121

BTB_POZ_KLHL24_KRIP6

cd18253

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

68-164

9.14e-23

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6) or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349562 [Multi-domain] Cd Length: 121 Bit Score: 93.75 E-value: 9.14e-23

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569  68 VGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGHLAIDQQNVQSLLMGASFLQLQNI 147
Cdd:cd18253   25 VEGREFPCHRAILSACSSYFRAMFCNDHRESREMLVEINGILAEAMDCFLQYVYTGKVKITTENVQYLFETSSLFQISPL 104

                         90
                 ....*....|....*..
gi 686585569 148 KDACCTFLRERLHPKNC 164
Cdd:cd18253  105 RDACAKFLEEQLDPCNC 121

BACK_KLHL21

cd18460

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a ...

159-257

2.95e-22

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively.

Pssm-ID: 350535 [Multi-domain] Cd Length: 101 Bit Score: 91.78 E-value: 2.95e-22

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569 159 LHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPFEDVLELVSRDELNVKSEEQVFEAALAWIRYDRD 238
Cdd:cd18460    1 LDVSNCLEMQDFAEAFACRGLAEAAKRFILRHIVELAKGEQFERLPLKRLLEYLSDDGLCVDKEETAYQIALRWVKADPK 80

                         90
                 ....*....|....*....
gi 686585569 239 QRESFLPELLSKIRLPLCR 257
Cdd:cd18460   81 HRQHFWPELLQHVRLPFVR 99

BTB_POZ_KLHL23

cd18252

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

73-166

3.57e-22

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 23 (KLHL23); KLHL23 overexpression is associated with increased cell proliferation and invasion in gastric cancer. Downregulation of KLHL23 is associated with invasion, metastasis, and poor prognosis of hepatocellular carcinoma and pancreatic cancer. KLHL23 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349561 [Multi-domain] Cd Length: 127 Bit Score: 92.20 E-value: 3.57e-22

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569  73 FSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGHLAIDQQNVQSLLMGASFLQLQNIKDACC 152
Cdd:cd18252   34 FHCHKAALAACSSYFKVMFTADMKEKSNNVIKLSGIDHDILEALVNYVYTSQICITERNVQSLLEAADLLQFISVKKACE 113

                         90
                 ....*....|....
gi 686585569 153 TFLRERLHPKNCLG 166
Cdd:cd18252  114 QFLVRHLDIDNCLG 127

BACK_KBTBD12

cd18485

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...

159-258

5.30e-22

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 12 (KBTBD12); KBTBD12, also termed Kelch domain-containing protein 6 (KLHDC6), is a BTB-Kelch family protein. Its function remains unclear.

Pssm-ID: 350560 [Multi-domain] Cd Length: 100 Bit Score: 90.94 E-value: 5.30e-22

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569 159 LHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPFEDVLELVSRDELNVKSEEQVFEAALAWIRYDRD 238
Cdd:cd18485    1 MDASNCLGIYYFAKQIGAEDLSDRARKYLYQHFTEVCLHEEVLEIEAHQLLTLIKSDDLNVSREESILDLVLRWVNHNRK 80

                         90       100
                 ....*....|....*....|
gi 686585569 239 QRESFLPELLSKIRLPLCRP 258
Cdd:cd18485   81 SRVQHLVELLKQVRLELVSP 100

BACK_KLHL24

cd18463

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also ...

158-235

1.12e-21

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6), or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of the BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation.

Pssm-ID: 350538 [Multi-domain] Cd Length: 78 Bit Score: 88.99 E-value: 1.12e-21

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 686585569 158 RLHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPFEDVLELVSRDELNVKSEEQVFEAALAWIRY 235
Cdd:cd18463    1 QLDPCNCLGIQKFADTHSLKQLFEKCKKFALENFVEVSQHEEFLELCKDELIEYISNDELVVPKEEEVFEAVMRWVYH 78

BTB_POZ_KLHL35

cd18265

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

67-166

1.72e-21

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 35 (KLHL35); KLHL35 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Significant differences in DNA methylation of the KLHL35 gene in abdominal aortic aneurysm (AAA) patients compared to non-AAA controls suggest a potential role in AAA pathology. Hypermethylation of the KLHL35 gene has also been associated with the development of hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349574 [Multi-domain] Cd Length: 128 Bit Score: 90.22 E-value: 1.72e-21

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569  67 RVGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGHLAIDQQNVQSLLMGASFLQLQN 146
Cdd:cd18265   29 LVDGKDFPCHRATLSANSAYFRAMFGGHLKESRQAVVEIQKVSAAAMEVLLDYMYGGGLRIQEDNVESVLEASDLLQVSK 108

                         90       100
                 ....*....|....*....|
gi 686585569 147 IKDACCTFLRERLHPKNCLG 166
Cdd:cd18265  109 LREACVRFLEGQLHPCNCLG 128

BACK_KLHL25_like

cd18464

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL25 and KLHL37; The ...

160-255

6.33e-21

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL25 and KLHL37; The family includes KLHL25 and KLHL37. KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). KLHL37, also called ectoderm-neural cortex protein 1 (ENC-1), or nuclear matrix protein NRP/B, or p53-induced gene 10 protein, is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells.

Pssm-ID: 350539 [Multi-domain] Cd Length: 98 Bit Score: 87.55 E-value: 6.33e-21

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569 160 HPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPFEDVLELVSRDELNVKSEEQVFEAALAWIRYDRDQ 239
Cdd:cd18464    1 HPSNCLGMLLLSDAHQCQRLYELSWRMCLANFTTLRKTEDFLSLPKDKLLELVSSEELEVEDERLVYEAVIGWIRYDLPR 80

                         90
                 ....*....|....*.
gi 686585569 240 RESFLPELLSKIRLPL 255
Cdd:cd18464   81 RHEVLPELLRSVRLAL 96

BACK_KLHL25_ENC2

cd18514

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also ...

159-255

6.65e-21

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1).

Pssm-ID: 350589 [Multi-domain] Cd Length: 99 Bit Score: 87.59 E-value: 6.65e-21

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569 159 LHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPFEDVLELVSRDELNVKSEEQVFEAALAWIRYDRD 238
Cdd:cd18514    1 LHPSNCLGMMLLSDAHQCRRLYELSWRMCLVHFETVRESEDFYSLSKDKLLDLISSDELEIEDEQVVFNAVLQWVKYDLE 80

                         90
                 ....*....|....*..
gi 686585569 239 QRESFLPELLSKIRLPL 255
Cdd:cd18514   81 KRKDYLPELLRNVRLAL 97

BACK_KLHL30

cd18469

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 30 (KLHL30); KLHL30 belongs ...

157-255

8.64e-21

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 30 (KLHL30); KLHL30 belongs to the KLHL family. Its function remains unclear. Differential expression of the KLHL30 gene has been observed in glioblastoma multiforme versus normal brain.

Pssm-ID: 350544 [Multi-domain] Cd Length: 104 Bit Score: 87.50 E-value: 8.64e-21

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569 157 ERLHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPFEDVLELVSRDELNVKSEEQVFEAALAWIRYD 236
Cdd:cd18469    1 QQIDATNCLGICEFGETHGCPEVAAKAWSFLLENFEAVSQEEEFLQLEKERLVACLGDDLLQVRDEQSRLEAVLRWVGHD 80

                         90
                 ....*....|....*....
gi 686585569 237 RDQRESFLPELLSKIRLPL 255
Cdd:cd18469   81 PQARAAHLPELLSLVHLSL 99

BACK_KLHL37_ENC1

cd18515

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 37 (KLHL37); KLHL37, also ...

160-255

1.20e-20

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 37 (KLHL37); KLHL37, also called ectoderm-neural cortex protein 1 (ENC-1), or nuclear matrix protein NRP/B, or p53-induced gene 10 protein, is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells.

Pssm-ID: 350590 [Multi-domain] Cd Length: 98 Bit Score: 86.95 E-value: 1.20e-20

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569 160 HPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPFEDVLELVSRDELNVKSEEQVFEAALAWIRYDRDQ 239
Cdd:cd18515    1 HPTNCLGMLLLSDAHQCTKLYELSWRMCLSNFQTICKTEDFLQLPKDMVVQLLSSEELETEDERLVYEAAINWVNYDLKK 80

                         90
                 ....*....|....*.
gi 686585569 240 RESFLPELLSKIRLPL 255
Cdd:cd18515   81 RHCYLSELLQTVRLAL 96

BACK_KBTBD3

cd18480

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...

163-240

3.52e-20

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also termed BTB and kelch domain-containing protein 3 (BKLHD3), is a BTB-Kelch family protein. Its function remains unclear.

Pssm-ID: 350555 [Multi-domain] Cd Length: 82 Bit Score: 85.07 E-value: 3.52e-20

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 686585569 163 NCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPFEdVLELV-SRDELNVKSEEQVFEAALAWIRYDRDQR 240
Cdd:cd18480    5 NCLQLLSFAESYGSTRLLDHALEFVMQHFSLLSQSQEFLELNFE-VLEKIlEADELNVPDEEAVLKAVLRWTKHDLEAR 82

BTB_POZ_KLHL41_KBTBD10

cd18341

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

67-167

3.86e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 41 (KLHL41); KLHL41 is also called Kel-like protein 23, Kelch repeat and BTB domain-containing protein 10 (KBTBD10), Kelch-related protein 1 (Krp1), or sarcosine. It is a novel kelch-related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349650 [Multi-domain] Cd Length: 133 Bit Score: 83.74 E-value: 3.86e-19

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569  67 RVGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGHLAIDQQNVQSLLMGASFLQLQN 146
Cdd:cd18341   33 KAGDKSLPCHRLILAACSPYFREYFLSEESEEKKKEVVLDNVDPNIMDMILKYLYSAEIDLNDGNVQDIFALASRFQIPS 112

                         90       100
                 ....*....|....*....|.
gi 686585569 147 IKDACCTFLRERLHPKNCLGV 167
Cdd:cd18341  113 VFTVCVTYLQKRLSPANCLAI 133

BACK_KLHL38

cd18476

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 38 (KLHL38); KLHL38 belongs ...

159-258

4.43e-19

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 38 (KLHL38); KLHL38 belongs to the KLHL family. Its function remains unclear. The klhl38 gene has recently been identified as a possible diapause (a temporary arrest of development during early ontogeny) gene, as it is significantly up-regulated during diapause. It may also be involved in chicken preadipocyte differentiation.

Pssm-ID: 350551 [Multi-domain] Cd Length: 99 Bit Score: 82.48 E-value: 4.43e-19

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569 159 LHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPFEDVLELVSRDELnVKSEEQVFEAALAWIRYDRD 238
Cdd:cd18476    1 LTPSNCLSMIRLSEILNCETLKKKAKDMALQCFPDVAASEDLKELCASELLDYLGDDEL-CGEEEQVFETLMVWIRHDPK 79

                         90       100
                 ....*....|....*....|
gi 686585569 239 QRESFLPELLSKIRLPLCRP 258
Cdd:cd18476   80 ARKGYIHDLFKKVRLQYVHP 99

BTB_POZ_calicin

cd18307

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

68-154

1.33e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in calicin; Calicin is a basic cytoskeletal protein involved in the formation and maintenance of the highly regular organization of the postacrosomal perinuclear theca, the calyx of mammalian spermatozoa. It contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349616 [Multi-domain] Cd Length: 97 Bit Score: 81.00 E-value: 1.33e-18

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569  68 VGDHKFSAHRIVLAASIPYFHAMFTNDMMeCKQDE----IVMQGMDPSALEALINFAYNGHLAIDQQNVQSLLMGASFLQ 143
Cdd:cd18307    8 VDNHSFAAHRNVLAAVSPFVKSLISSNDM-KATDElsitIDCDYLSPETVEQLLDYFYTGKIVISEKNVEDLLKGAKYFN 86

                         90
                 ....*....|.
gi 686585569 144 LQNIKDACCTF 154
Cdd:cd18307   87 IPRLKDHCVDF 97

BTB_POZ_KBTBD2_BKLHD1

cd18270

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

72-165

3.19e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulation of insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349579 [Multi-domain] Cd Length: 133 Bit Score: 81.20 E-value: 3.19e-18

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569  72 KFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGHLAIDQQNVQSLLMGASFLQLQNIKDAC 151
Cdd:cd18270   37 EFPCHKMVLATCSSYFRAMFMSGLSESKQTHVHLRNVDAATLQIIITYAYTGNLAINDSTVEQLYETACFLQVEDVLQRC 116

                         90
                 ....*....|....
gi 686585569 152 CTFLRERLHPKNCL 165
Cdd:cd18270  117 REYLIKKINAENCV 130

BACK_KLHL40_like

cd18477

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL40 and KLHL41; The ...

159-255

1.03e-17

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL40 and KLHL41; The family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells.

Pssm-ID: 350552 [Multi-domain] Cd Length: 99 Bit Score: 78.73 E-value: 1.03e-17

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569 159 LHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPFEDVLELVSRDELNVKSEEQVFEAALAWIRYDRD 238
Cdd:cd18477    1 LCLGNCLAIFRLGLLLDCPRLAVSARDFICAHFTLVAKDEDFLGLSADELIAIISSDGLNVEKEEAVFEAVMKWVREAKE 80

                         90
                 ....*....|....*..
gi 686585569 239 QRESFLPELLSKIRLPL 255
Cdd:cd18477   81 NRQKALPTVFESIRFRL 97

PHA02713

hypothetical protein; Provisional

68-458

2.03e-17

hypothetical protein; Provisional

Pssm-ID: 165086 [Multi-domain] Cd Length: 557 Bit Score: 85.83 E-value: 2.03e-17

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569  68 VGD-HKFSAHRIVLAASIPYFHAMFTNDM-MECKQDEIVMQGMDPSALEALINFAYNGHlaIDQQNVQSLLMGASFLQLQ 145
Cdd:PHA02713  32 IGDgEEIKAHKTILAAGSKYFRTLFTTPMiIRDLVTRVNLQMFDKDAVKNIVQYLYNRH--ISSMNVIDVLKCADYLLID 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569 146 NIKDACCTFLRERLHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPFEDVLELVS-RDELNVKSEEQ 224
Cdd:PHA02713 110 DLVTDCESYIKDYTNHDTCIYMYHRLYEMSHIPIVKYIKRMLMSNIPTLITTDAFKKTVFEILFDIIStNDNVYLYREGY 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569 225 VFEAALAWIRYDRDQRESFL--------PELLSKIRL-----------PLCrPQFLTDRVQQDDLV--RCCHKCRD---- 279
Cdd:PHA02713 190 KVTILLKWLEYNYITEEQLLcilscidiQNLDKKSRLllysnktinmyPSC-IQFLLDNKQNRNIIprQLCLVCHDtkyn 268

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569 280 ------LVDE--AKDYHLMPERRPHLPAFKTrprccTSIAGLIYAVGGLNSAGDSLNVVEVFDpIANRWE-KCQPMTTAR 350
Cdd:PHA02713 269 vcnpciLVYNinTMEYSVISTIPNHIINYAS-----AIVDNEIIIAGGYNFNNPSLNKVYKIN-IENKIHvELPPMIKNR 342

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569 351 SRVGVAVVNGLLYAIGGYDGQLRLSTVEVYNPEMDSWSKVESMNSKRSAMGTVVLDGQIYVCGGY--------------- 415
Cdd:PHA02713 343 CRFSLAVIDDTIYAIGGQNGTNVERTIECYTMGDDKWKMLPDMPIALSSYGMCVLDQYIYIIGGRtehidytsvhhmnsi 422

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*..
gi 686585569 416 ----DGNSSlNSVESYSPETNKWTVVTPMSSNRSAAGVTVFEGRIYV 458
Cdd:PHA02713 423 dmeeDTHSS-NKVIRYDTVNNIWETLPNFWTGTIRPGVVSHKDDIYV 468

BTB_POZ_KBTBD3_BKLHD3

cd18271

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

68-165

2.15e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also called BTB and kelch domain-containing protein 3 (BKLHD3), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349580 [Multi-domain] Cd Length: 130 Bit Score: 78.72 E-value: 2.15e-17

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569  68 VGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGHLAIDQQNVQSLLMGASFLQLQNI 147
Cdd:cd18271   31 VKDETIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTISNLSPKAVKAFLDYAYTGKAEITDDNVEMFFQMSSFLQVSLL 110

                         90
                 ....*....|....*...
gi 686585569 148 KDACCTFLRERLHPKNCL 165
Cdd:cd18271  111 SKACSDFLIKSIDLTNCL 128

Kelch

Kelch domain;

408-454

2.29e-17

Kelch domain;

Pssm-ID: 128874 [Multi-domain] Cd Length: 47 Bit Score: 75.67 E-value: 2.29e-17

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 686585569   408 QIYVCGGYDGNSSLNSVESYSPETNKWTVVTPMSSNRSAAGVTVFEG 454
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47

BACK_KBTBD8

cd18483

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...

159-254

2.39e-17

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8); KBTBD8, also called T-cell activation kelch repeat protein (TA-KRP), is a BTB-kelch family protein that is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis. It acts as a substrate-specific adaptor for a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex monoubiquitylates NOLC1 and its paralogue TCOF1, the mutation of which underlies the neurocristopathy Treacher Collins syndrome.

Pssm-ID: 350558 [Multi-domain] Cd Length: 97 Bit Score: 77.59 E-value: 2.39e-17

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569 159 LHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPFEDVLELVSRDELNVKSEEQVFEAALAWIRYDRD 238
Cdd:cd18483    1 LDPQNSIGVFIFADHYGHQELKERSQDYIRKKFLSVTKEQEFLHLTKDQLISILNSDDLNVEKEEHVYESIIHWFEHEQS 80

                         90
                 ....*....|....*..
gi 686585569 239 QRESFLPELLSK-IRLP 254
Cdd:cd18483   81 KREMHLPEIFAKcIRMP 97

BTB_POZ_KLHL15

cd18244

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

70-164

2.57e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 15 (KLHL15); KLHL15 is a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that targets the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits. It also plays a key role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR), by targeting the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. KLHL15 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349553 [Multi-domain] Cd Length: 137 Bit Score: 78.84 E-value: 2.57e-17

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569  70 DHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGHLAIDQQNVQSLLMGASFLQLQNIKD 149
Cdd:cd18244   39 DHQFQAHKALLATQSDYFRIMFTADMRERDQDKIHLKGLTATGFSHVLQFMYYGTIELSMLTVHEILQAAMYVQLTEVVK 118

                         90
                 ....*....|....*
gi 686585569 150 ACCTFLRERLHPKNC 164
Cdd:cd18244  119 FCCSFLLAKICLDNC 133

PHA02790

Kelch-like protein; Provisional

79-528

3.17e-17

Kelch-like protein; Provisional

Pssm-ID: 165153 [Multi-domain] Cd Length: 480 Bit Score: 84.71 E-value: 3.17e-17

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569  79 VLAASIPYFHAMFTNDMMECKQDEI-VMQGMDPSALEALINFAYNGHLAIDQQNVQSLLMGASFLQLQNIKDACCTFLRE 157
Cdd:PHA02790  39 ILKKLSPYFRTHLRQKYTKNKDPVTrVCLDLDIHSLTSIVIYSYTGKVYIDSHNVVNLLRASILTSVEFIIYTCINFILR 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569 158 RLHPKNCLgvrqfaETMMCAVLYDAAN------SFIHQHFVEVS--MSEEFLALPFEDVLElvsRDELNVKSEEQVFEAA 229
Cdd:PHA02790 119 DFRKEYCV------ECYMMGIEYGLSNllchtkDFIAKHFLELEddIIDNFDYLSMKLILE---SDELNVPDEDYVVDFV 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569 230 LAWIRYDRDQRESFLPELLSKIRLPLCRPQFLTDRVQQDDLVRCCHkCRDLVDEAKDYHLMpERRPHLPAFKTRPRCCTS 309
Cdd:PHA02790 190 IKWYMKRRNRLGNLLLLIKNVIRSNYLSPRGINNVKWILDCTKIFH-CDKQPRKSYKYPFI-EYPMNMDQIIDIFHMCTS 267

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569 310 --IAGLIYAVGGLNSaGDSLNVVEVFDPIANRWEKCQPMTTARSRVGVAVVNGLLYAIGGYDGQlrlSTVEVYNPEMDSW 387
Cdd:PHA02790 268 thVGEVVYLIGGWMN-NEIHNNAIAVNYISNNWIPIPPMNSPRLYASGVPANNKLYVVGGLPNP---TSVERWFHGDAAW 343

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569 388 SKVESMNSKRSAMGTVVLDGQIYVCGGYDGNSSlnSVESYSPETNKWTVVTPMSSNRSAAGVTVFEGRIYVSGghdglqi 467
Cdd:PHA02790 344 VNMPSLLKPRCNPAVASINNVIYVIGGHSETDT--TTEYLLPNHDQWQFGPSTYYPHYKSCALVFGRRLFLVG------- 414

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 686585569 468 fNSVEYYNHHTATWHPVASMLNKRCRHGAASLGSKMFVCGGYDGSGFLSIAEVYSSMADQW 528
Cdd:PHA02790 415 -RNAEFYCESSNTWTLIDDPIYPRDNPELIIVDNKLLLIGGFYRGSYIDTIEVYNNRTYSW 474

NanM

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];

479-581

5.25e-17

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];

Pssm-ID: 442289 [Multi-domain] Cd Length: 277 Bit Score: 81.36 E-value: 5.25e-17

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569 479 ATWHPVASMLNKRCRHGAASLGSKMFVCGGYDGSGFLSIAEVYSSMADQWYLIVPMN-SRRSRVSLVANCGRLYAVGGYD 557
Cdd:COG3055    1 ATWSSLPDLPTPRSEAAAALLDGKVYVAGGLSGGSASNSFEVYDPATNTWSELAPLPgPPRHHAAAVAQDGKLYVFGGFT 80

                         90       100
                 ....*....|....*....|....*...
gi 686585569 558 GQSN----LSSVEMYDPETNRWTFMAPM 581
Cdd:COG3055   81 GANPsstpLNDVYVYDPATNTWTKLAPM 108

BACK_KBTBD2

cd18479

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...

159-253

8.73e-17

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulating the insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation.

Pssm-ID: 350554 [Multi-domain] Cd Length: 96 Bit Score: 75.86 E-value: 8.73e-17

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569 159 LHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPFEDVLELVSRDELNVKSEEQVFEAALAWIRYDRD 238
Cdd:cd18479    1 INAENCVRLLSFADLFSCEELKQSAKRMVEHKFTAVYHQEAFMQLSHDLLIDILSSDNLNVEKEETVREAAMLWLEYNTE 80

                         90
                 ....*....|....*
gi 686585569 239 QRESFLPELLSKIRL 253
Cdd:cd18479   81 SRSQYLSSVLSQIRI 95

BACK_KLHL23

cd18462

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 23 (KLHL23); KLHL23 is ...

163-255

1.39e-16

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 23 (KLHL23); KLHL23 is involved in tumorigenesis and resistance to anticancer drug treatment. It also associates with cone-rod dystrophy.

Pssm-ID: 350537 [Multi-domain] Cd Length: 102 Bit Score: 75.54 E-value: 1.39e-16

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569 163 NCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPFEDVLELVSRDELNVKSEEQVFEAALAWIRYDRDQRES 242
Cdd:cd18462    5 NCLGMHSFAEFHVCPELEKESRRIILSRFEEVWQQEEFLELSKEKLLYILSRENLNVWKEEVLIEAVVKWVAHDVEKRIE 84

                         90
                 ....*....|...
gi 686585569 243 FLPELLSKIRLPL 255
Cdd:cd18462   85 CAYDLLSSIKLDL 97

BTB_POZ_KLHL36

cd18266

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

70-171

1.75e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349575 [Multi-domain] Cd Length: 135 Bit Score: 76.47 E-value: 1.75e-16

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569  70 DHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGHLAIDQQNVQSLLMGASFLQLQNIKD 149
Cdd:cd18266   34 EQRVPAHRNLLAVCSDYFNSMFTIGMREAHQKEVELVGASYIGLKAVIDFLYSSELPLDGGNIDYVLETAHLLQIWKVVD 113

                         90       100
                 ....*....|....*....|..
gi 686585569 150 ACCTFLRERLHPKNCLGVRQFA 171
Cdd:cd18266  114 FCCEYLENEVSEENYLYLQELA 135

BTB_POZ_KLHL22

cd18251

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

75-155

1.93e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of polo-like kinase 1 (PLK1) at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates mono-ubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349560 [Multi-domain] Cd Length: 125 Bit Score: 76.01 E-value: 1.93e-16

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569  75 AHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGHLAIDQQNVQSLLMGASFLQLQNIKDACCTF 154
Cdd:cd18251   37 AHRILLAASCDYFRGMFAGGLREMQQTEVLIHGVSYNAMCKILDFIYTSELELSLDNVQETLTAACQLQIPEVIGFCCDF 116


                 .
gi 686585569 155 L 155
Cdd:cd18251  117 L 117

BACK_KLHL40_KBTBD5

cd18516

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also ...

163-255

2.72e-16

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5, or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy.

Pssm-ID: 350591 [Multi-domain] Cd Length: 99 Bit Score: 74.41 E-value: 2.72e-16

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569 163 NCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPFEDVLELVSRDELNVKSEEQVFEAALAWIRYDRDQRES 242
Cdd:cd18516    5 NCLAIFRLGLLLDCPRLAVAARDFICDRFQLIARDEDFLQLSPDELIAIISSDSLNVEKEEDVFEAVMKWVGKDQEERTK 84

                         90
                 ....*....|...
gi 686585569 243 FLPELLSKIRLPL 255
Cdd:cd18516   85 ALPVLLESIRFRL 97

BACK_KLHL41_KBTBD10

cd18517

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 41 (KLHL41); KLHL41, also ...

159-255

4.26e-16

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 41 (KLHL41); KLHL41, also called Kel-like protein 23, or Kelch repeat and BTB domain-containing protein 10, or Kelch-related protein 1 (Krp1), or sarcosine, is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils.

Pssm-ID: 350592 [Multi-domain] Cd Length: 99 Bit Score: 74.04 E-value: 4.26e-16

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569 159 LHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPFEDVLELVSRDELNVKSEEQVFEAALAWIRYDRD 238
Cdd:cd18517    1 LSVGNCLAIFRLGLLLDCPRLAVSARDFVSDRFEQISKEEDFLQLAPHELIAIISSDSLNVEKEELVFEAVMKWVRTDKE 80

                         90
                 ....*....|....*..
gi 686585569 239 QRESFLPELLSKIRLPL 255
Cdd:cd18517   81 NRVKSLGEIFDCIRFRL 97

BTB_POZ_KLHL16_gigaxonin

cd18245

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

68-155

9.96e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349554 [Multi-domain] Cd Length: 111 Bit Score: 73.14 E-value: 9.96e-16

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569  68 VGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQD--EIVMQGMDPSALEALINFAYNGHLAIDQQNVQSLLMGASFLQLQ 145
Cdd:cd18245   21 VGGEEIPVQKNVLAAASPYFRAKLNYNPPKDDGStyKIELEGISVEVMEEILDYIYTGQIKLSEDNIQDIVQAADLLLMT 100

                         90
                 ....*....|
gi 686585569 146 NIKDACCTFL 155
Cdd:cd18245  101 DLKDLCCEFL 110

BACK_NS1BP_IVNS1ABP

cd18502

BACK (BTB and C-terminal Kelch) domain found in influenza virus NS1A-binding protein (NS1-BP); ...

159-250

1.06e-15

BACK (BTB and C-terminal Kelch) domain found in influenza virus NS1A-binding protein (NS1-BP); NS1-BP, also called NS1-binding protein, or Aryl hydrocarbon receptor-associated protein 3, or IVNS1ABP, is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control.

Pssm-ID: 350577 Cd Length: 99 Bit Score: 72.65 E-value: 1.06e-15

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569 159 LHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPFEDVlELV--SRDELNVKSEEQVFEAALAWIRYD 236
Cdd:cd18502    1 LTPENCIGIRSFAGRMNDSELLQKVDSYIQENIEEVAESKEFLKLPRLQI-EVIleSNQELESINERKLCQLVLEWVQRS 79

                         90
                 ....*....|....
gi 686585569 237 RDQRESFLPELLSK 250
Cdd:cd18502   80 IEEGGLDLDDLTEK 93

BACK_KLHL33

cd18472

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 33 (KLHL33); KLHL33 belongs ...

159-232

2.06e-15

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 33 (KLHL33); KLHL33 belongs to the KLHL family. Its function remains unclear. KLHL33 SNPs may be associated with prostate cancer risk.

Pssm-ID: 350547 [Multi-domain] Cd Length: 75 Bit Score: 71.26 E-value: 2.06e-15

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 686585569 159 LHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPFEDVLELVSRDELNVKSEEQVFEAALAW 232
Cdd:cd18472    1 LSPANCLELWAFADAATLPRLAAAARAFALKHFAEVAASAAFLSLPLARLLELLRSDELEVAEEEAVFEAAVRW 74

BACK

cd14733

BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal ...

160-214

2.76e-15

BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal to a BTB domain, in a diverse set of architectures together with Kelch, MATH, and/or TAZ domains. It is involved in interactions with the Cullin3 (Cul3) ubiquitin ligase complex, as well as in homo-oligomerization. Most proteins containing the BACK domain are understood to function as adaptor proteins that play a role in ubiquitination of various substrates.

Pssm-ID: 350515 [Multi-domain] Cd Length: 55 Bit Score: 70.00 E-value: 2.76e-15

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 686585569 160 HPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPFEDVLELVSR 214
Cdd:cd14733    1 DPENCLGILELADLYNLEELKEKALKFILENFEEVSKSEEFLELSVELLLELLSS 55

BTB_POZ_KLHL9_13

cd18239

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

69-164

4.39e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL9 and KLHL13; KLHL9 and KLHL13 (also called BTB and kelch domain-containing protein 2, or BKLHD2) are substrate-specific adaptors of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes, thereby coordinating faithful mitotic progression and completion of cytokinesis. They contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349548 [Multi-domain] Cd Length: 128 Bit Score: 72.14 E-value: 4.39e-15

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569  69 GDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGHLAIDQQNVQSLLMGASFLQLQNIK 148
Cdd:cd18239   33 GDETFPVHRAMMASASDYFKAMFTGGMKEQELMCIKLHGVSKIGLKNIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVL 112

                         90
                 ....*....|....*.
gi 686585569 149 DACCTFLRERLHPKNC 164
Cdd:cd18239  113 DFCKVLLISGVTLENC 128

Kelch_1

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...

397-441

4.51e-15

Pssm-ID: 396078 [Multi-domain] Cd Length: 46 Bit Score: 69.18 E-value: 4.51e-15

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 686585569  397 RSAMGTVVLDGQIYVCGGYDGNSSLNSVESYSPETNKWTVVTPMS 441
Cdd:pfam01344   2 RSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46

BACK_KLHL31_KBTBD1

cd18470

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 31 (KLHL31); KLHL31, also ...

162-253

7.95e-15

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 31 (KLHL31); KLHL31, also termed BTB and kelch domain-containing protein 6, or Kelch repeat and BTB domain-containing protein 1, or Kelch-like protein KLHL, is a transcriptional repressor in MAPK/JNK signaling pathway that regulates cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE).

Pssm-ID: 350545 Cd Length: 98 Bit Score: 70.29 E-value: 7.95e-15

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569 162 KNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPFEDVLELVSRDELNVKSEEQVFEAALAWIRYDrDQRE 241
Cdd:cd18470    4 ENCMYVVNIAETYGLKNTKEAAQKFIRDNFIEFSETDQFLKLTFEQINEFLIDDDLQLPSEITAFQIAMKWLDFD-QKRV 82

                         90
                 ....*....|..
gi 686585569 242 SFLPELLSKIRL 253
Cdd:cd18470   83 KYAADLLSNIRF 94

BTB_POZ_trishanku-like

cd18314

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...

68-151

1.19e-14

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349623 [Multi-domain] Cd Length: 96 Bit Score: 69.68 E-value: 1.19e-14

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569  68 VGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGHLAIDQQNVQSLLMGASFLQLQNI 147
Cdd:cd18314   13 VGDRKFFAHRIVLCARSPVFRSMLTGSMIESNLKEVTLEDVEPEIFETVLKYMYTGQVTLSEENVLDLLMLASKYQVPDL 92


                 ....
gi 686585569 148 KDAC 151
Cdd:cd18314   93 EKLC 96

Kelch_1

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...

349-394

4.17e-14

Pssm-ID: 396078 [Multi-domain] Cd Length: 46 Bit Score: 66.48 E-value: 4.17e-14

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 686585569  349 ARSRVGVAVVNGLLYAIGGYDGQLRLSTVEVYNPEMDSWSKVESMN 394
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46

BTB_POZ_KLHL32

cd18261

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

69-165

5.28e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also called BTB and kelch domain-containing protein 5 (BKLHD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Deletion of KLHL32 may be ssociated with Tourette syndrome and obsessive-compulsive disorder. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349570 [Multi-domain] Cd Length: 133 Bit Score: 69.22 E-value: 5.28e-14

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569  69 GDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGHLAIDQQNVQSLLMGASFLQLQNIK 148
Cdd:cd18261   36 EEQKFHAHKAVLAACSDYFRAMFSLCMVESEADEVNLHGVTSLGLKQALDFAYTGQILLEPGVIQDVLAAGSHLQLLELL 115

                         90
                 ....*....|....*..
gi 686585569 149 DACCTFLRERLHPKNCL 165
Cdd:cd18261  116 SLCSHYLIQELNSFNYL 132

BTB_POZ_BAB-like

cd18315

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...

69-143

6.61e-14

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349624 [Multi-domain] Cd Length: 85 Bit Score: 67.19 E-value: 6.61e-14

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 686585569  69 GDHKFSAHRIVLAASIPYFHAMFTnDMMECKQDEIVMQGMDPSALEALINFAYNGHLAIDQQNVQSLLMGASFLQ 143
Cdd:cd18315    9 EGGSLKAHKLVLAAASPYFAALLK-ETPPDEHPVIILPDVPYSELKALLDFIYTGEVNVSQEQLESLLKLAELLQ 82

BTB_POZ_BTBD9

cd18287

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

68-155

6.82e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349596 [Multi-domain] Cd Length: 119 Bit Score: 68.42 E-value: 6.82e-14

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569  68 VGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGHLA---IDQQNVQSLLMGA---SF 141
Cdd:cd18287   29 VEEKRFPAHRVILAARSEYFRALLYGGMRESQQSEIELKDTNAEAFKALLKYIYTGRLTltdLKEDVLLDVLGLAhqyGF 108

                         90
                 ....*....|....
gi 686585569 142 LQLQNikdACCTFL 155
Cdd:cd18287  109 EELEA---AISDYL 119

BACK_KLHL35

cd18474

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 35 (KLHL35); KLHL35 belongs ...

163-236

9.13e-14

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 35 (KLHL35); KLHL35 belongs to the KLHL family. Its function remains unclear. Hypermethylation of KLHL35 is associated with hepatocellular carcinoma and abdominal aortic aneurysm.

Pssm-ID: 350549 [Multi-domain] Cd Length: 79 Bit Score: 66.76 E-value: 9.13e-14

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 686585569 163 NCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPFEDVLELVSRDELNVKSEEQVFEAALAWIRYD 236
Cdd:cd18474    5 NCLALLAAADALHCAPLQEHCIRVLLRDFAQAARHPSFLKLELQLVLELLADDSLAVRSEEVVLEAALRWVDAD 78

Kelch

Kelch domain;

455-500

1.07e-13

Kelch domain;

Pssm-ID: 128874 [Multi-domain] Cd Length: 47 Bit Score: 65.27 E-value: 1.07e-13

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 686585569   455 RIYVSGGHDGLQIFNSVEYYNHHTATWHPVASMLNKRCRHGAASLG 500
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVIN 46

Kelch_1

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...

537-581

1.11e-13

Pssm-ID: 396078 [Multi-domain] Cd Length: 46 Bit Score: 65.33 E-value: 1.11e-13

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 686585569  537 RRSRVSLVANCGRLYAVGGYDGQSNLSSVEMYDPETNRWTFMAPM 581
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSM 45

Kelch

Kelch domain;

549-590

4.31e-13

Kelch domain;

Pssm-ID: 128874 [Multi-domain] Cd Length: 47 Bit Score: 63.73 E-value: 4.31e-13

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 686585569   549 RLYAVGGYDGQSNLSSVEMYDPETNRWTFMAPMVCHEGGVGV 590
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGV 42

Kelch

Kelch domain;

361-407

4.80e-13

Kelch domain;

Pssm-ID: 128874 [Multi-domain] Cd Length: 47 Bit Score: 63.73 E-value: 4.80e-13

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 686585569   361 LLYAIGGYDGQLRLSTVEVYNPEMDSWSKVESMNSKRSAMGTVVLDG 407
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47

BTB_POZ_KLHL11

cd18241

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

69-164

5.38e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349550 [Multi-domain] Cd Length: 135 Bit Score: 66.42 E-value: 5.38e-13

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569  69 GDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQ------GMDPSALEALINFAYNGHLAIDQQNVQSLLMGASFL 142
Cdd:cd18241   34 GGREFRAHRSVLAAATEYFTPLLSGQFSESRSGRVEMRkwssepGPDPDTVEAVIQYMYTGRIRVSTGNVHEVLELADRF 113

                         90       100
                 ....*....|....*....|..
gi 686585569 143 QLQNIKDACCTFLRERLHPKNC 164
Cdd:cd18241  114 LLIRLKEFCGEFLKKKLNLSNC 135

BACK_KLHL26

cd18465

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is a ...

162-255

1.08e-12

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is a kelch family protein encoded by gene klhl26, which is regulated by p53 via fuzzy tandem repeats.

Pssm-ID: 350540 Cd Length: 97 Bit Score: 64.16 E-value: 1.08e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569 162 KNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPFEDVLELVSRDELNVKSEEQVFEAALAWIRYDrDQRE 241
Cdd:cd18465    4 ETCLNIGQMATTFSLASLKESVDAFTFRHFLQIAEEEDFLHLPLERLVFFLQSNKLKNCSEIDLFRAAIRWLQHD-PSRR 82

                         90
                 ....*....|....
gi 686585569 242 SFLPELLSKIRLPL 255
Cdd:cd18465   83 ASASHVLCHIRFPL 96

BTB_POZ

cd01165

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

68-142

1.11e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.

Pssm-ID: 349496 [Multi-domain] Cd Length: 79 Bit Score: 63.45 E-value: 1.11e-12

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 686585569  68 VGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGHLAIDQQNVQSLLMGASFL 142
Cdd:cd01165    5 VEGEKFHVNKELLAQSSEYFRALFRGGFRESGQAEINLRDISPEDFRALLEFLYGGKRDLDASNLLELLEAANFL 79

BTB2_POZ_BTBD8

cd18286

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

58-160

1.81e-12

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349595 [Multi-domain] Cd Length: 121 Bit Score: 64.20 E-value: 1.81e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569  58 SSYCVHTGNRVGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGHLAI-DQQNVQSLL 136
Cdd:cd18286   14 NGEDSDITIKVDGKTFKAHRCILCARSSYFAAMLSGSWAESNSSEITLTGVSHAAVSFVLLFIYGGVLDLpDDVNLGELL 93

                         90       100
                 ....*....|....*....|....*
gi 686585569 137 MGASFLQLQNIKD-ACCTFLRERLH 160
Cdd:cd18286   94 SLADMYGLDGLKDvVAYTLRRDYCH 118

BTB_POZ_ZBTB37

cd18222

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

68-162

2.37e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37); ZBTB37 may be involved in transcriptional regulation. It is differentially expressed in aryl hydrocarbon receptor (AhR)-KO mice compared with WT mice, and may potentially contribute to the aging phenotype of AhR-KO mice. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349531 [Multi-domain] Cd Length: 123 Bit Score: 64.29 E-value: 2.37e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569  68 VGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMqgmDPSALEALINFAYNGHLAIDQQNVQSLLMGASFLQLQNI 147
Cdd:cd18222   32 VQGQSFRAHKVVLAASSPYFRDHMSLNEMSTVSISVIK---NPTVFEQLLSFCYTGRICLQLADIISYLTAASFLQMQHI 108

                         90
                 ....*....|....*
gi 686585569 148 KDACCTFLrERLHPK 162
Cdd:cd18222  109 IDKCTQIL-EGIHFK 122

Kelch

Kelch domain;

313-360

2.95e-12

Kelch domain;

Pssm-ID: 128874 [Multi-domain] Cd Length: 47 Bit Score: 61.42 E-value: 2.95e-12

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 686585569   313 LIYAVGGLNSaGDSLNVVEVFDPIANRWEKCQPMTTARSRVGVAVVNG 360
Cdd:smart00612   1 KIYVVGGFDG-GQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47

BTB2_POZ_KLHL33

cd18263

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

68-165

3.32e-12

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349572 [Multi-domain] Cd Length: 118 Bit Score: 63.68 E-value: 3.32e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569  68 VGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGHLAIDQQNVQSLLMGASFLQLQNI 147
Cdd:cd18263   20 ADGSIFRVHRVILAAGSDYFRAMFTSGMKESTQSVVQLPTIPAKDLRLLISFAYSGILHLSWENLFEATCTALQLQISGA 99

                         90
                 ....*....|....*...
gi 686585569 148 KDACCTFLRERLHPKNCL 165
Cdd:cd18263  100 LALCLDFLQREISPARCL 117

BACK_calicin

cd18503

BACK (BTB and C-terminal Kelch) domain found in calicin; Calicin is a basic cytoskeletal ...

163-235

4.12e-12

BACK (BTB and C-terminal Kelch) domain found in calicin; Calicin is a basic cytoskeletal protein involved in the formation and maintenance of the highly regular organization of the postacrosomal perinuclear theca, the calyx of mammalian spermatozoa.

Pssm-ID: 350578 [Multi-domain] Cd Length: 78 Bit Score: 61.98 E-value: 4.12e-12

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 686585569 163 NCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPFEDVLELVSRDELNVKSEEQVFEAALAWIRY 235
Cdd:cd18503    5 NCLTALCLATTAGLKDLSDEIYDYIRDNFFDVSGTREFLQCPYDIFSRLLKDENLHVNNEDQVLLALLNWTEH 77

BTB_POZ_BACH

cd18955

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

68-155

4.64e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog (BACH) proteins; This subfamily includes BACH1 (also called BTB-basic leucine zipper transcription factor 1), BACH2 (also called BTB-basic leucine zipper transcription factor 2), and similar proteins. They belong to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). Subfamily members contain a BTB domain and a basic leucine zipper (bZIP) domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349736 [Multi-domain] Cd Length: 94 Bit Score: 62.49 E-value: 4.64e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569  68 VGDHKFSAHRIVLAASIPYFHAMFT----NDMMECKQDEIVMQGMDPsaleaLINFAYNGHLAIDQQNVQSLLMGASFLQ 143
Cdd:cd18955    8 VEDQRFRAHRAVLAACSDYFLSRVVgqtdGDLVITLPEEVTVKGFEP-----LLQFAYTAKLLLSKENVLEVCRCAEFLG 82

                         90
                 ....*....|..
gi 686585569 144 LQNIKDACCTFL 155
Cdd:cd18955   83 VHNIEKACFDFL 94

BTB_POZ_ZBTB7A

cd18326

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

68-155

7.45e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A); ZBTB7A is also called factor binding IST protein 1 (FBI-1), factor that binds to inducer of short transcripts protein 1, HIV-1 1st-binding protein 1, Leukemia/lymphoma-related factor (LRF), POZ and Krueppel erythroid myeloid ontogenic factor, POK erythroid myeloid ontogenic factor, Pokemon, TTF-I-interacting peptide 21 (TIP21), or zinc finger protein 857A (ZNF857A). It is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. It has been implicated in carcinogenesis and cell differentiation and development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349635 [Multi-domain] Cd Length: 120 Bit Score: 62.65 E-value: 7.45e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569  68 VGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGHLAIDQQNVQSLLMGASFLQLQNI 147
Cdd:cd18326   32 VEGREFPTHRSVLAACSQYFKKLFTSGAVVDQQNVYEIDFVSAEALTALLDFAYTATLTVSTSNVGDILSAARLLEIPAV 111


                 ....*...
gi 686585569 148 KDACCTFL 155
Cdd:cd18326  112 SHVCADLL 119

BTB_POZ_ZBTB47_ZNF651

cd18231

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

73-158

9.68e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 47 (ZBTB47); ZBTB47, also called zinc finger protein 651 (ZNF651), is a paralog of ZNF652, a novel zinc-finger transcriptional repressor. It interacts with CBFA2T3 via its carboxy-terminal proline-rich region. CBFA2T3-ZNF651 functions as a transcriptional co-repressor complex. ZBTB47 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349540 [Multi-domain] Cd Length: 115 Bit Score: 62.25 E-value: 9.68e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569  73 FSAHRIVLAASIPYFHAMFTNDMmECKQDEIVMQGMDPSALEALINFAYNGHLAIDQQNVQSLLMGASFLQLQNIKDACC 152
Cdd:cd18231   28 FPAHKGVLAAYSQFFHSLFTQNK-QLQRVELSLEALTSQGLQQILNFIYTSKLLVNSCNVQDVLNAAAVLQMNDIAASCQ 106


                 ....*.
gi 686585569 153 TFLRER 158
Cdd:cd18231  107 ELIDSR 112

BACK_KLHL9_13

cd18449

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL9 and KLHL13; KLHL9 ...

163-254

1.44e-11

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL9 and KLHL13; KLHL9 and KLHL13 (also termed BTB and kelch domain-containing protein 2, or BKLHD2) are substrate-specific adaptors of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis.

Pssm-ID: 350524 [Multi-domain] Cd Length: 95 Bit Score: 60.90 E-value: 1.44e-11

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569 163 NCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPFEDVLELVSRDELNVKSEEQVFEAALAWIRYDRDqRES 242
Cdd:cd18449    5 NCVEIGRIANTYHLTEVDKYVNDFILKNFPALLSTGDFVKLPFERLAFVLSSNSLKGCTELELFKAACRWLRHEDD-RMQ 83

                         90
                 ....*....|..
gi 686585569 243 FLPELLSKIRLP 254
Cdd:cd18449   84 FAAKLMENIRFP 95

BTB_POZ_KLHL34

cd18264

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

72-164

1.75e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 34 (KLHL34); KLHL34 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The methylation status of KLHL34 cg14232291 appears to be predictive of pathologic response to preoperative chemoradiation therapy in rectal cancer patients. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349573 [Multi-domain] Cd Length: 136 Bit Score: 62.12 E-value: 1.75e-11

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569  72 KFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGHLAIDQQNVQSLLMGASFLQLQNIKDAC 151
Cdd:cd18264   39 EFPAHRSLLACSSDYFRALFKDYTQESKARVIHLPVVSAAGLQRVLDFIYTSWLSLSLDTLEDTLEAASYLQVTEAIGLC 118

                         90
                 ....*....|...
gi 686585569 152 CTFLRERLHPKNC 164
Cdd:cd18264  119 SQYLINNLAPENC 131

BTB_POZ_KLHL29_KBTBD9

cd18258

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

72-166

2.50e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 29 (KLHL29); KLHL29 is also called Kelch repeat and BTB domain-containing protein 9 (KBTBD9). A novel fusion transcript NR5A2-KLHL29FT, resulting from transchromosomal insertion, may influence the origin or progression of colon cancer. KLHL29 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349567 [Multi-domain] Cd Length: 125 Bit Score: 61.14 E-value: 2.50e-11

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569  72 KFSAHRIVLAASIPYFHAMF---TNDMMECKQDEIVMQGMDPSALEALINFAYNGHLAIDQQNVQSLLMGASFLQLQNIK 148
Cdd:cd18258   28 EFEVHQNVLASCSLYFKDLIkrsSRDSGGGEKLELTMSNINADVLELLLEFVYTGSLIIDSANAKTLLEAANKFQFHTFC 107

                         90
                 ....*....|....*...
gi 686585569 149 DACCTFLRERLHPKNCLG 166
Cdd:cd18258  108 KVCVSFLEKQLTASNCLG 125

Kelch_1

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...

444-487

2.63e-11

Pssm-ID: 396078 [Multi-domain] Cd Length: 46 Bit Score: 58.78 E-value: 2.63e-11

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 686585569  444 RSAAGVTVFEGRIYVSGGHDGLQIFNSVEYYNHHTATWHPVASM 487
Cdd:pfam01344   2 RSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSM 45

BTB_POZ_BACH1

cd18277

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

68-155

3.21e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 1 (BACH1); BACH1, also called BTB-basic leucine zipper transcription factor 1, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. It can act as repressor or activator. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. It is also a negative regulator of nuclear factor erythroid 2-related factor 2 (Nrf2) that controls antioxidant response elements (ARE)-dependent gene expressions. BACH1 binds to NF-E2 binding sites in vitro, and plays important roles in coordinating transcription activation and repression by MafK. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349586 [Multi-domain] Cd Length: 120 Bit Score: 60.85 E-value: 3.21e-11

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569  68 VGDHKFSAHRIVLAASIPYFHAMFTN----DMMECKQDEIVMQGMDPsaleaLINFAYNGHLAIDQQNVQSLLMGASFLQ 143
Cdd:cd18277   34 VEGQRFRAHRSVLAACSSYFHSRIVGqadaELNITLPEEVTVKGFEP-----LIQFAYTAKLILSKDNVDEVCKCVEFLS 108

                         90
                 ....*....|..
gi 686585569 144 LQNIKDACCTFL 155
Cdd:cd18277  109 VHNIEESCFQFL 120

BTB_POZ_ZBTB24_ZNF450

cd18212

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

68-150

7.14e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 24 (ZBTB24); ZBTB24, also called zinc finger protein 450, functions as a transcription factor essentially involved in B-cell functions in humans. The loss-of-function mutations in ZBTB24 can cause ICF2 (immunodeficiency, centromeric instability and facial anomalies syndrome 2) with immunological characteristics of greatly reduced serum antibodies and circulating memory B cells. ZBTB24 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349521 [Multi-domain] Cd Length: 118 Bit Score: 59.81 E-value: 7.14e-11

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569  68 VGDHKFSAHRIVLAASIPYFHAMFTnDMMECKQDEIVMQGMDPSALEALINFAYNGHLAIDQQNVQSLLMGASFLQLQNI 147
Cdd:cd18212   30 VENVQFRAHKALLAASSEYFSMMFA-DEGEVGQSIYMLEGMVAETFGALLEFIYTGCLQVGEKSLEQILATAQFLKVNDL 108


                 ...
gi 686585569 148 KDA 150
Cdd:cd18212  109 VKA 111

BTB_POZ_BPM_plant

cd18280

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

68-121

9.82e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in plant BTB/POZ-MATH (BPM) protein family; The BPM protein family includes Arabidopsis thaliana BTB/POZ and MATH domain-containing proteins, AtBPM1-6, and similar proteins from other plants. BPM protein, also called protein BTB-POZ and MATH domain, may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349589 [Multi-domain] Cd Length: 121 Bit Score: 59.26 E-value: 9.82e-11

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 686585569  68 VGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAY 121
Cdd:cd18280   21 VDGEKFRAHKLVLAARSPVFRSMLFGPMREENEGEIVIEDVEPPVFKALLHFIY 74

BTB_POZ_ZBTB22_BING1

cd18210

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

73-155

1.05e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 22 (ZBTB22); ZBTB22, also called protein BING1 or zinc finger protein 297, may be involved in transcriptional regulation. Its gene, together with BING 3-5, TAPASIN, DAXX, RGL2, and HKE2, form a dense cluster at the centromeric end of the major histocompatibility complex class I region. ZBTB22 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349519 [Multi-domain] Cd Length: 112 Bit Score: 59.08 E-value: 1.05e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569  73 FSAHRIVLAASIPYFHamftNDMMECKQDEIVMQG-MDPSALEALINFAYNGHLAIDQQNVQSLLMGASFLQLQNIKDAC 151
Cdd:cd18210   33 FRAHRAVLAASSPYFH----DQVLLKNMSSISLPGvMDPGAFESVLASAYTGKLTMLADEIVNYLTVGSVLQMWHIVDKC 108


                 ....
gi 686585569 152 CTFL 155
Cdd:cd18210  109 TELL 112

BTB_POZ_ZBTB49

cd18233

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

73-156

1.42e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 49 (ZBTB49); ZBTB49, also called zinc finger protein 509 (ZNF509), is a transcription factor that inhibits cell proliferation by activating either CDKN1A/p21 transcription or RB1 transcription. There are four ZNF509 isoforms generated by alternative splicing. Short ZNF509 (ZNF509S1, -S2 and -S3) isoforms contain one or two out of the seven zinc-fingers contained in long ZNF509 (ZNF509L). ZBTB49 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349542 [Multi-domain] Cd Length: 112 Bit Score: 58.75 E-value: 1.42e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569  73 FSAHRIVLAASIPYFHAMFTNDMMEcKQDEIVMQGMDPSALEALINFAYNGHLAIDQQNVQSLLMGASFLQLQNIKDACC 152
Cdd:cd18233   30 FKAHKNVLAAFSQYFRSLFQNSSSQ-KNDVFHLDIKNVGGIGQILDFMYTSHLDLNQDNVQVMLDIAQCLQVQNVLNMCY 108


                 ....
gi 686585569 153 TFLR 156
Cdd:cd18233  109 TFLK 112

BACK_KLHL11

cd18451

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a ...

159-246

1.79e-10

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation.

Pssm-ID: 350526 [Multi-domain] Cd Length: 88 Bit Score: 57.66 E-value: 1.79e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569 159 LHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPFEDVLELVSRDELNVKSEEQVFEAALAWIRYDRD 238
Cdd:cd18451    1 LNLSNCVAIHSLAHMYSLDQLALKAADMIRRNFHKVIQDEEFYTLPFHLVRDWLSDAEITVDSEEVLFEAVLKWVQRNAE 80


                 ....*...
gi 686585569 239 QRESFLPE 246
Cdd:cd18451   81 ERERYFEE 88

PRK14131

N-acetylneuraminate epimerase;

319-461

2.06e-10

N-acetylneuraminate epimerase;

Pssm-ID: 237617 [Multi-domain] Cd Length: 376 Bit Score: 62.73 E-value: 2.06e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569 319 GLNSAGDSLNVVEVFDPiANRWEK-CQPMTTARSRVGVAVVNGLLYAIGGY-----DGQLRL-STVEVYNPEMDSWSKVE 391
Cdd:PRK14131  44 GLGSAGTSWYKLDLNAP-SKGWTKiAAFPGGPREQAVAAFIDGKLYVFGGIgktnsEGSPQVfDDVYKYDPKTNSWQKLD 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569 392 SmnskRSAMG-----TVVLDG-QIYVCGGY---------------DGNSSL-------------------NSVESYSPET 431
Cdd:PRK14131 123 T----RSPVGlaghvAVSLHNgKAYITGGVnknifdgyfedlaaaGKDKTPkdkindayfdkkpedyffnKEVLSYDPST 198

                        170       180       190
                 ....*....|....*....|....*....|..
gi 686585569 432 NKWTV--VTPMSSNRSAAgVTVFEGRIYVSGG 461
Cdd:PRK14131 199 NQWKNagESPFLGTAGSA-VVIKGNKLWLING 229

BTB_POZ_ABTB2-like

cd18297

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

73-159

2.24e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349606 [Multi-domain] Cd Length: 117 Bit Score: 58.05 E-value: 2.24e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569  73 FSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGH---LAIDQQNVQSLLMGASFLQLQNIKD 149
Cdd:cd18297   24 FYAHKIVLVTASDRFKSMLSSGSTEAQTPVIEIPDIRYDIFQLMMQYLYTGGvesLDVAQDDALELLRAASFFQLDGLKR 103

                         90
                 ....*....|
gi 686585569 150 ACCTFLRERL 159
Cdd:cd18297  104 HCEILLSQQI 113

BTB_POZ_ZBTB44

cd18228

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

67-159

2.60e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 44 (ZBTB44); ZBTB44, also called BTB/POZ domain-containing protein 15 (BTBD15) or zinc finger protein 851 (ZNF851), may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB44 showed a suggestive association with disease progression of Crohn's disease. ZBTB44 has also preferentially been recognized by sera of patients with peripheral T-cell lymphoma (PTCL). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349537 [Multi-domain] Cd Length: 126 Bit Score: 58.33 E-value: 2.60e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569  67 RVGDHKFSAHRIVLAASIPYFHAMF----------TNDMMECKQD--EIVMQGMDPsaleaLINFAYNGHLAIDQQNVQS 134
Cdd:cd18228   25 RVQDKIFRAHKVVLAACSDFFRSKLvgqasprlvlVSPAGKCVLDlhHVTVTGFAP-----LLEYAYTSTLSINTENIID 99

                         90       100
                 ....*....|....*....|....*
gi 686585569 135 LLMGASFLQLQNIKDACCTFLRERL 159
Cdd:cd18228  100 VLAAASYMQMFNVANTCSEFMKSSI 124

BTB_POZ_BACH2

cd18278

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

72-155

3.09e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 2 (BACH2); BACH2, also called BTB-basic leucine zipper transcription factor 2, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). It is also a potent general repressor of effector differentiation in naive T cells. Moreover, BACH2 is required for pulmonary surfactant homeostasis and alveolar macrophage function. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349587 [Multi-domain] Cd Length: 124 Bit Score: 58.04 E-value: 3.09e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569  72 KFSAHRIVLAASIPYFHAMFT----NDMMECKQDEIVMQGMDPsaleaLINFAYNGHLAIDQQNVQSLLMGASFLQLQNI 147
Cdd:cd18278   42 EFRAHRAVLAACSEYFLQALVgqteNDLVVSLPEEVTARGFGP-----LLQFAYTAKLLLSRENIQEVIRCAEFLRMHNL 116


                 ....*...
gi 686585569 148 KDACCTFL 155
Cdd:cd18278  117 EDSCFRFL 124

BTB_POZ_SPOPL

cd18343

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

68-151

5.66e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein-like (SPOPL); SPOPL, also called HIB homolog 2 or Roadkill homolog 2, is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The complexes may contain homodimeric SPOPL or the heterodimers formed by speckle-type POZ protein (SPOP) and SPOPL, which are less efficient than ubiquitin ligase complexes containing only SPOP. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349652 [Multi-domain] Cd Length: 123 Bit Score: 57.32 E-value: 5.66e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569  68 VGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGHLAIDQQNVQSLLMGASFLQLQNI 147
Cdd:cd18343   28 VGGQEFKAHKSILAARSPVFNAMFEHEMEESKKNRVEINDVDPEVFKEMMRFIYTGKAPNLDKMADNLLAAADKYALERL 107


                 ....
gi 686585569 148 KDAC 151
Cdd:cd18343  108 KVMC 111

BTB_POZ_ZBTB43

cd18227

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

68-156

6.66e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 43 (ZBTB43); ZBTB43, also called zinc finger and BTB domain-containing protein 22B (ZBTB22b), zinc finger protein 297B (ZNF297B), or ZnF-x, may be involved in transcriptional regulation. It interacts with BDP1, a subunit of transcription factor IIIB (TFIIIB). Since BDP1 is essential in Pol III transcription, ZBTB43 may also regulate these transcriptional pathways. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349536 [Multi-domain] Cd Length: 121 Bit Score: 56.87 E-value: 6.66e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569  68 VGDHKFSAHRIVLAASIPYFhamfTNDMMECKQDEIVMQG-MDPSALEALINFAYNGHLAIDQQNVQSLLMGASFLQLQN 146
Cdd:cd18227   32 VQGHLFRAHKAVLAASSPYF----CDQVLLKNSRRIVLPDvMNPRVFENILLSCYTGRLVLPAPEIVSYLTAASFLQMWH 107

                         90
                 ....*....|
gi 686585569 147 IKDACCTFLR 156
Cdd:cd18227  108 VVDKCTELLE 117

BTB_POZ_BTBD1_2

cd18281

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

65-163

6.77e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD1 and BTBD2; This family includes BTB/POZ domain-containing proteins BTBD1 and BTBD2, both of which are BTB-domain-containing Kelch-like proteins that interact with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349590 [Multi-domain] Cd Length: 127 Bit Score: 57.06 E-value: 6.77e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569  65 GNRVGDHKFSAHRIVLAASIPYFHAMFtNDMMECKQDEIVMQGMDPSALEALINFAYNGHLAIDQQNVQSLLMGASFLQL 144
Cdd:cd18281   30 GKGDNEQRIPAHKFVLSIGSAVFDAMF-NGGMATTSAEIELPDVEPAAFLALLRFLYSDEVQIGPETVMTTLYTAKKYAV 108

                         90
                 ....*....|....*....
gi 686585569 145 QNIKDACCTFLRERLHPKN 163
Cdd:cd18281  109 PALESACVEFLKKNLSSDN 127

BTB_POZ_ZBTB3

cd18323

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

68-158

6.99e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 3 (ZBTB3); ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB3 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349632 [Multi-domain] Cd Length: 128 Bit Score: 57.14 E-value: 6.99e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569  68 VGDHKFSAHRIVLAASIPYFHaMFTNDMME-----CKQDEIVMqgmdPSALEALINFAYNGHLAIDQQNVQSLLMGASFL 142
Cdd:cd18323   30 VGSTQFLAHRAVLASCSPFFH-MFYKEQLDkrdlvCINNEIVT----APAFSLLLEFMYEGRLSFNDTPVEDVLAAASYL 104

                         90
                 ....*....|....*.
gi 686585569 143 QLQNIKDACCTFLRER 158
Cdd:cd18323  105 HMNDIVKVCKKRLQAR 120

BTB_POZ_KLHL31_KBTBD1

cd18260

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

73-165

7.09e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 31 (KLHL31); KLHL31 is also called BTB and kelch domain-containing protein 6 (BKLHD6), Kelch repeat and BTB domain-containing protein 1 (KBTBD1), or Kelch-like protein KLHL. It is a transcriptional repressor in the MAPK/JNK signaling pathway to regulate cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE). It is also a novel modulator of canonical Wnt signaling, which is important for vertebrate myogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349569 [Multi-domain] Cd Length: 120 Bit Score: 56.75 E-value: 7.09e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569  73 FSAHRIVLAASIPYFHAMFTNDMmecKQDEIVMQGMDPSALEALINFAYNGHLAIDQQNVQSLLMGASFLQLQNIKDACC 152
Cdd:cd18260   30 FDVHKVVMASCSEYFRNILKKDP---SLQRVELNDISPLGLATVITYAYTGKLTLSLYTIGSTISAASYLQIHALVKMCC 106

                         90
                 ....*....|...
gi 686585569 153 TFLRERLHPKNCL 165
Cdd:cd18260  107 DFLMQEMNVENCM 119

BTB_POZ_KBTBD11

cd18275

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

68-167

8.60e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 11 (KBTBD11); KBTBD11 is also called chronic myelogenous leukemia-associated protein (CMLAP) or Kelch domain-containing protein 7B, or KLHDC7C. It is a BTB-Kelch family protein whose function remains unclear. A novel polymorphism rs11777210 in KBTBD11 is significantly associated with colorectal cancer risk. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349584 [Multi-domain] Cd Length: 104 Bit Score: 56.34 E-value: 8.60e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569  68 VGDHKFSAHRIVLAASIPYFHAMFTNDMMEckqdeivMQGMDPSALEALINFAYNGHLAIDQQNVQSLLMGASFLQLQNI 147
Cdd:cd18275   11 VSGQRIRAHKSVLAAKSDYFRARLSRDILK-------VKGLSYATLRLLVDYVYSGRMAVSKDNVVEVVAGARFLQMPCA 83

                         90       100
                 ....*....|....*....|
gi 686585569 148 KDACCTFLRERLHPKNCLGV 167
Cdd:cd18275   84 AQCAVDAVRAQLCLGNCYEV 103

BACK_KLHL22

cd18461

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a ...

163-266

1.11e-09

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of Polo-like kinase 1 (PLK1) at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates monoubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation.

Pssm-ID: 350536 Cd Length: 104 Bit Score: 55.92 E-value: 1.11e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569 163 NCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPFEDVLELVSRDELNVKSEEQVFEAALAWirydrdqreS 242
Cdd:cd18461    5 NILDVYKLADLFHLTHLSEQLDSYILKNFPTFSRTETYRQLPLEKVYSLLSSNRLEVDSENEVYEGALLY---------H 75

                         90       100
                 ....*....|....*....|....
gi 686585569 243 FLPELLSKIRLPLCRPQFLTDRVQ 266
Cdd:cd18461   76 YTPEQVEKDQVSLQEPPKLLEAVR 99

BTB_POZ_ZBTB34

cd18220

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

73-160

1.12e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 34 (ZBTB34); ZBTB34 acts as a transcriptional regulator. It downregulates specificity protein (Sp) transcription factors Sp1, Sp3, and Sp4 in pancreatic cancer cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349529 [Multi-domain] Cd Length: 120 Bit Score: 56.57 E-value: 1.12e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569  73 FSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMqgmDPSALEALINFAYNGHLAIDQQNVQSLLMGASFLQLQNIKDACC 152
Cdd:cd18220   37 FRAHKAVLAASSPYFRDHSALSTMSGLSISVIK---NPNVFEQLLSFCYTGRMSLQLKDVVSFLTAASFLQMQCVIDKCT 113


                 ....*...
gi 686585569 153 TFLrERLH 160
Cdd:cd18220  114 QIL-ESIH 120

BTB_POZ_SPOP-like

cd18279

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

68-155

1.16e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins; This family includes speckle-type POZ protein (SPOP), speckle-type POZ protein-like (SPOPL), TD and POZ domain-containing proteins (TDPOZ), Drosophila melanogaster protein roadkill and similar proteins. Both, SPOP and SPOPL, serve as adaptors of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and proteasomal degradation of target proteins. TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domains. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349588 [Multi-domain] Cd Length: 120 Bit Score: 56.38 E-value: 1.16e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569  68 VGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGHLAIDQQNVQSLLMGASFLQLQNI 147
Cdd:cd18279   25 VGGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVDPEVFKEMMRFIYTGKAPNLDKMADDLLAAADKYALERL 104

                         90
                 ....*....|..
gi 686585569 148 K----DACCTFL 155
Cdd:cd18279  105 KvmceDALCSNL 116

BTB_POZ_ZBTB42

cd18956

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

68-158

1.20e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 42 (ZBTB42); ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. It is enriched in skeletal muscles, especially at the neuromuscular junction. A ZBTB42 mutation has been identified to define a novel lethal congenital contracture syndrome (LCCS6), a lethal autosomal recessive form of arthrogryposis multiplex congenita (AMC). ZBTB42 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349737 [Multi-domain] Cd Length: 129 Bit Score: 56.36 E-value: 1.20e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569  68 VGDHKFSAHRIVLAASIPYFHaMFTNDMMECKQDEIVMQG--MDPSALEALINFAYNGHLAIDQQNVQSLLMGASFLQLQ 145
Cdd:cd18956   30 VGDARFPAHRAVLAACSVYFH-LFYRDRPAGGRDTVRLNGdiVTAPAFGRLLDFMYEGRLDLRSLPVEDVLAAASYLHMY 108

                         90
                 ....*....|...
gi 686585569 146 NIKDACCTFLRER 158
Cdd:cd18956  109 DIVKVCKGRLREK 121

BTB_POZ_GCL

cd18305

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

70-157

1.33e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein germ cell-less (GCL) and similar proteins; GCL proteins are nuclear envelope proteins highly conserved between the mammalian and Drosophila orthologs. Drosophila melanogaster GCL is a key regulator required for the specification of pole cells and primordial germ cell formation in embryos. Both, human germ cell-less protein-like 1 (GMCL1) and germ cell-less protein-like 2 (GMCL2), also called germ cell-less protein-like 1-like (GMCL1P1 or GMCL1L), may function in spermatogenesis. They may also be substrate-specific adaptors of E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. They contain BTB and BACK domains. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349614 [Multi-domain] Cd Length: 115 Bit Score: 56.13 E-value: 1.33e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569  70 DHKFSAHRIVLAASiPYFHAMFTNDMMECKQDEIVMQGMDPSAL-EAL-INFA--YNGHLAIDQQNVQSLLMGASFLQLQ 145
Cdd:cd18305   24 GREWKLHKIYLCQS-GYFASMFSGSWKESKETVINLEIPDDNITvEALnVVFGslYRDEIEIKPSRVVSILAAATLLQLD 102

                         90
                 ....*....|..
gi 686585569 146 NIKDACCTFLRE 157
Cdd:cd18305  103 GLIQQCSEVMKE 114

BTB_POZ_ZBTB17_MIZ1

cd18206

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

73-154

2.08e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 17 (ZBTB17); ZBTB1 is also called c-Myc-interacting zinc finger protein 1 (Miz-1), zinc finger protein 151, or zinc finger protein 60. It is a poly-Cys2His2 zinc finger (ZF) transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. ZBTB17 has been implicated in cardiomyopathy and is important in cardiac stress response. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349515 [Multi-domain] Cd Length: 112 Bit Score: 55.32 E-value: 2.08e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569  73 FSAHRIVLAASIPYFHAMFTNdmmecKQDEIVMQGMDPSALEALINFAYNGHLAIDQQNVQSLLMGASFLQLQNIKDACC 152
Cdd:cd18206   34 FKAHKAVLAACSEYFRMLFVD-----QKDVVHLDISNAAGLGQVLEFMYTAKLSLSPENVDDVLAVATFLQMQDIVTACH 108


                 ..
gi 686585569 153 TF 154
Cdd:cd18206  109 AL 110

BTB_POZ_BTBD17

cd18292

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

67-154

2.23e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also called galectin-3-binding protein-like, is a BTB domain-containing protein. Its function remains unclear. It may be associated with hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349601 [Multi-domain] Cd Length: 114 Bit Score: 55.37 E-value: 2.23e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569  67 RVGDHKFSAHRIVLAASIPYFHAMFTND-MMECKQDEIVMQgMDP---SALEALINFAYNGHLAIDQQNVQSLLMGASFL 142
Cdd:cd18292   23 RVGGKVFHAHRLILAKSSDVFRVMLSNDwWSESKQSEIELV-EDPecaAVFEKFLRYLYTGQISVNLETALPLLMLADKY 101

                         90
                 ....*....|..
gi 686585569 143 QLQNIKDACCTF 154
Cdd:cd18292  102 NVTDLKQLCVDF 113

BTB_POZ_ZBTB9

cd18200

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

55-157

2.83e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 9 (ZBTB9); ZBTB9 may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349509 [Multi-domain] Cd Length: 111 Bit Score: 54.86 E-value: 2.83e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569  55 RDASSYC---VHTGNRVgdhkFSAHRIVLAASIPYFH-AMFTNDmmeckQDEIVMQG-MDPSALEALINFAYNGHLAIDQ 129
Cdd:cd18200   13 RLEGKFCdlsVHVQGRV----FRAHKAVLAASSPYFHdKLLLND-----TNCLVLPSvIEAAAFENLLQLIYSGRLTLCM 83

                         90       100
                 ....*....|....*....|....*...
gi 686585569 130 QNVQSLLMGASFLQLQNIKDACCTFLRE 157
Cdd:cd18200   84 DALPSHLLVASGLQMWQVVDRCSELLKE 111

BTB_POZ_KBTBD4

cd18272

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

68-167

3.16e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 4 (KBTBD4); KBTBD4, also called BTB and kelch domain-containing protein 4 (BKLHD4), is a BTB-BACK-Kelch domain protein belonging to a large family of cullin-RING ubiquitin ligase adaptors that facilitate the ubiquitination of target substrates. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349581 [Multi-domain] Cd Length: 140 Bit Score: 55.67 E-value: 3.16e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569  68 VGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGHLAIDQQNVQSLLMGASFLQLQNI 147
Cdd:cd18272   39 VEGKEFQLHRLVLSAQSCFFRSMFTSNLKEARNRVIELKDVSESVFQLLVDYIYHGTVKLRVEELQETYEVADMYQLTAL 118

                         90       100
                 ....*....|....*....|
gi 686585569 148 KDACCTFLRERLHPKNCLGV 167
Cdd:cd18272  119 FEECSRFLARTVQVRNCLQV 138

BTB_POZ_ZBTB3-like

cd18194

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

68-159

3.43e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18, ZBTB42 and similar proteins; The family includes zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18 and ZBTB42. ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB18 is a sequence-specific transrepressor associated with heterochromatin. ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349503 [Multi-domain] Cd Length: 128 Bit Score: 55.21 E-value: 3.43e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569  68 VGDHKFSAHRIVLAASIPYFHaMFTNDMME-----CKQDEIVMqgmdPSALEALINFAYNGHLAIDQQNVQSLLMGASFL 142
Cdd:cd18194   30 VGSAQFPAHRAVLASCSMYFH-LFYRDRLDkrdlvRLNSDIVT----APAFGLLLDFMYEGRLALRDLPVEDVLAAASYL 104

                         90
                 ....*....|....*..
gi 686585569 143 QLQNIKDACCTFLRERL 159
Cdd:cd18194  105 HMYDIVKVCKGRLQEKA 121

BTB_POZ_ZBTB7C_ZBTB36

cd18328

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

68-151

3.55e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7C (ZBTB7C); ZBTB7C is also called affected by papillomavirus DNA integration in ME180 cells protein 1 (APM-1), zinc finger and BTB domain-containing protein 36 (ZBTB36), zinc finger protein 857C (ZNF857C), or kidney cancer-related POZ domain and Kruppel-like protein (Kr-POK). It is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. It may act as an important regulator of fatty acid synthesis and may induce rapid cancer cell proliferation by increasing palmitate synthesis. The ZBTB7C gene has been identified as a susceptibility gene to ischemic injury. ZBTB7C contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349637 [Multi-domain] Cd Length: 120 Bit Score: 54.89 E-value: 3.55e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569  68 VGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGHLAIDQQNVQSLLMGASFLQLQNI 147
Cdd:cd18328   32 VQDQEYRTHRSVLAACSKYFKKLFTAGTLADQPYVYEIDFVTPEALSAILEFAYTSTLTITTSNVKHILNAAQMLEIQCI 111


                 ....
gi 686585569 148 KDAC 151
Cdd:cd18328  112 INVC 115

BACK_BTBD9

cd14822

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 9 (BTBD9); ...

179-255

4.90e-09

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation.

Pssm-ID: 350518 [Multi-domain] Cd Length: 101 Bit Score: 53.77 E-value: 4.90e-09

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 686585569 179 LYDAANSFIHQHFVEVSMSEEFLALPFEDVLELVSRDELNVkSEEQVFEAALAWIRYdRDQRESFLPELLSKIRLPL 255
Cdd:cd14822   21 LCQTCCQFMDRNAQEVLSSEGFLTLSKSALKELLSRDSFCA-PEVDIFNAVRRWCEH-NPDSKEDAKEILEAVRLPL 95

Kelch_1

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...

491-535

5.94e-09

Pssm-ID: 396078 [Multi-domain] Cd Length: 46 Bit Score: 51.84 E-value: 5.94e-09

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 686585569  491 RCRHGAASLGSKMFVCGGYDGSGFLSIAEVYSSMADQWYLIVPMN 535
Cdd:pfam01344   2 RSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46

BTB_POZ_BTBD14B_NAC1

cd18290

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

68-154

6.06e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 1 (NAC-1); NAC-1, also called BTB/POZ domain-containing protein 14B (BTBD14B), is a transcriptional repressor that contributes to tumor progression, tumor cell proliferation, and survival. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349599 [Multi-domain] Cd Length: 123 Bit Score: 54.27 E-value: 6.06e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569  68 VGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQgmdPSALEALINFAYNGHLAIDQQNVQSLLMGASFLQLQNI 147
Cdd:cd18290   34 VKGHAFKAHRAVLAASSSYFRDLFNSSRSAVVELPAAVQ---PQSFQQILSFCYTGRLSMNVGDQFLLMYTAGFLQIQEI 110


                 ....*..
gi 686585569 148 KDACCTF 154
Cdd:cd18290  111 MEKGTEF 117

BTB_POZ_ZBTB21_ZNF295

cd18209

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

68-142

6.36e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 21 (ZBTB21); ZBTB21, also called zinc finger protein 295 (ZNF295), is a transcription repressor that acts in a selective manner on different promoters. It may be involved in the bi-directional control of gene expression in concert with another transcription factor ZFP161. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349518 [Multi-domain] Cd Length: 112 Bit Score: 54.11 E-value: 6.36e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569  68 VGDHKFSAHRIVLAASIPYFHAMFTNDMMEcKQDEIVMQGMDPSALEALINFAYNGHLAIDQQN---VQSL--LMGASFL 142
Cdd:cd18209   25 VGDQKFRAHKNVLAASSEYFQSLFTEKENE-SQSVFQLDFCEPDAFENVLNYIYSSSLFVEKSSlaaVQELgySLGISFL 103

BTB_POZ_ZBTB46

cd18230

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

73-159

6.49e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 46 (ZBTB46); ZBTB46 is also called BTB-ZF protein expressed in effector lymphocytes (BZEL), BTB/POZ domain-containing protein 4 (BTBD4), or zinc finger protein 340 (ZNF340). It is a conventional dendritic cell (cDC) lineage specific transcription factor that acts as a negative regulator required to prevent activation of classical dendritic cells in the steady state. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349539 [Multi-domain] Cd Length: 125 Bit Score: 54.30 E-value: 6.49e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569  73 FSAHRIVLAASIPYFHAMFTNDMMECKQ------DEIVMQGmdpsaLEALINFAYNGHLAIDQQNVQSLLMGASFLQLQN 146
Cdd:cd18230   33 FKAHKNVLLGSSRYFKTLYCQVQKTSDQatvthlDIVTAQG-----FKAIIDFMYSAHLALTSKNVIEVMSAASYLQMTD 107

                         90
                 ....*....|...
gi 686585569 147 IKDACCTFLRERL 159
Cdd:cd18230  108 IVQACHNFIKAAL 120

BTB_POZ_ZBTB7

cd18198

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

67-155

8.42e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7 (ZBTB7); There are three ZBTB7 isoforms: ZBTB7A, ZBTB7B, and ZBTB7C. ZBTB7A is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. ZBTB7B is a transcriptional regulator of extracellular matrix gene expression. ZBTB7C is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. ZBTB7 isoforms contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349507 [Multi-domain] Cd Length: 120 Bit Score: 53.72 E-value: 8.42e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569  67 RVGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGHLAIDQQNVQSLLMGASFLQLQN 146
Cdd:cd18198   31 LVQGREYRTHRSVLAACSQYFKKLFTSGAVVDQQNVYEIDFVSPEALTALLEFAYTATLTVSTANVGDILSAARLLEIPC 110


                 ....*....
gi 686585569 147 IKDACCTFL 155
Cdd:cd18198  111 VSHVCAEIL 119

BTB_POZ_ZBTB8A_BOZF1

cd18329

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

73-155

9.58e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8A (ZBTB8A); ZBTB8A, also called BTB/POZ and zinc-finger domain-containing factor or BTB/POZ and zinc-finger domains factor on chromosome 1 (BOZ-F1), is a novel proto-oncoprotein that stimulates cell proliferation. It binds to all the proximal GC boxes to repress transcription, and it inhibits p53 acetylation without affecting p53 stability. It may be involved in gastric adenocarcinoma cell differentiation, cancer invasion, and metastasis. ZBTB8A contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349638 [Multi-domain] Cd Length: 116 Bit Score: 53.68 E-value: 9.58e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569  73 FSAHRIVLAASIPYFHAMFTNDMMECKQDEIV-MQGMDPSALEALINFAYNGHLAIDQQNVQSLLMGASFLQLQNIKDAC 151
Cdd:cd18329   33 FKAHRNVLFASSGYFKMLLSQNAKETGQPTVAtFDVFSPDTFTIILDFVYSGKLSLTSQNVIEVMSAASYLQMTDVISVC 112


                 ....
gi 686585569 152 CTFL 155
Cdd:cd18329  113 KTFI 116

BTB_POZ_roadkill-like

cd18345

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

68-155

1.03e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein roadkill and similar proteins; Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349654 [Multi-domain] Cd Length: 121 Bit Score: 53.70 E-value: 1.03e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569  68 VGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGHLAIDQQNVQSLLMGASFLQLQNI 147
Cdd:cd18345   25 VGGREFQAHKAILAARSPVFNAMFEHEMEERKQNRVEITDVDHEVMREMLRFIYTGKAPNLDKMADDLLAAADKYALERL 104

                         90
                 ....*....|..
gi 686585569 148 KDAC----CTFL 155
Cdd:cd18345  105 KVMCeealCSNL 116

BTB_POZ_BTBD19

cd18294

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

68-155

1.19e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349603 [Multi-domain] Cd Length: 111 Bit Score: 53.02 E-value: 1.19e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569  68 VGDHKF--SAHRIVLAASIPYFHAMF-TNDMMECKQDEIVMQGMDPSALEALINFAYNGHLAIDQQNVQSLLMGASFLQL 144
Cdd:cd18294   21 VGPERQeiFAHKCILAARCEVFRAMFlTGPQKESTQSPLVLSDIEPEVFRAVLEFIYTNCVTLSNHTVIEVLAAAVEYGL 100

                         90
                 ....*....|.
gi 686585569 145 QNIKDACCTFL 155
Cdd:cd18294  101 DELRKLCERFI 111

BTB_POZ_ZBTB18_RP58

cd18324

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

68-158

1.34e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18 (ZBTB18); ZBTB18 is also called 58 kDa repressor protein (RP58), transcriptional repressor RP58, translin-associated zinc finger protein 1 (TAZ-1), zinc finger protein 238 (ZNF238), or zinc finger protein C2H2-171. It is a sequence-specific transrepressor associated with heterochromatin. It plays a role in various developmental processes such as myogenesis and brain development. It specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. ZBTB18 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349633 [Multi-domain] Cd Length: 147 Bit Score: 53.89 E-value: 1.34e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569  68 VGDHKFSAHRIVLAASIPYFHaMFTNDMMEcKQDeIVMQGMD---PSALEALINFAYNGHLAIDQQNVQSLLMGASFLQL 144
Cdd:cd18324   30 VGDAQFRAHRAVLASCSMYFH-LFYKDQLD-KRD-IVHLNSDivtAPAFALLLEFMYEGKLQFKDLPIEDVLAAASYLHM 106

                         90
                 ....*....|....
gi 686585569 145 QNIKDACCTFLRER 158
Cdd:cd18324  107 YDIVKVCKKKLKEK 120

PLN02193

nitrile-specifier protein

295-461

1.66e-08

nitrile-specifier protein

Pssm-ID: 177844 [Multi-domain] Cd Length: 470 Bit Score: 57.27 E-value: 1.66e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569 295 PHLPAFKTRprcCTSIAGLIYAVGGlNSAGDSLNVVEVFDPIANRWEKCQPMT---TARSRVGVAVVNGLLYAIGGYDGQ 371
Cdd:PLN02193 215 PHLSCLGVR---MVSIGSTLYVFGG-RDASRQYNGFYSFDTTTNEWKLLTPVEegpTPRSFHSMAADEENVYVFGGVSAT 290

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569 372 LRLSTVEVYNPEMDSW----SKVESMnSKRSAMGTVVLDGQIYVCGGYDGnSSLNSVESYSPETNKWTVVTPMS---SNR 444
Cdd:PLN02193 291 ARLKTLDSYNIVDKKWfhcsTPGDSF-SIRGGAGLEVVQGKVWVVYGFNG-CEVDDVHYYDPVQDKWTQVETFGvrpSER 368

                        170
                 ....*....|....*..
gi 686585569 445 SAAGVTVFEGRIYVSGG 461
Cdd:PLN02193 369 SVFASAAVGKHIVIFGG 385

BTB2_POZ_RhoBTB

cd18300

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

67-159

1.95e-08

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, a tandem of 2 BTB domains, and a conserved C-terminal region. In humans, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349609 [Multi-domain] Cd Length: 108 Bit Score: 52.24 E-value: 1.95e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569  67 RVGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGHLAIdQQNVQS--LLMGASFLQL 144
Cdd:cd18300   15 IVEDGTIPAHKALLVARCDVMAAMFGGNFRESSAKEVELPGVSKETFLALLEYLYTDQAPI-LEDGDCvgLIVLANRLCL 93

                         90
                 ....*....|....*
gi 686585569 145 QNIKDACCTFLRERL 159
Cdd:cd18300   94 PRLVALCEQYIVKEL 108

BTB_POZ_ZBTB31_myoneurin

cd18217

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

68-151

2.31e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in myoneurin; Myoneurin, also called zinc finger and BTB domain-containing protein 31 (ZBTB31), is a novel member of the BTB/POZ-zinc finger family highly expressed in the neuromuscular system and is associated with neuromuscular junctions during the late embryonic period. It may function as a synaptic gene regulator. Myoneurin contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349526 [Multi-domain] Cd Length: 111 Bit Score: 52.45 E-value: 2.31e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569  68 VGDHKFSAHRIVLAASIPYFHAMFtndmmECKQDEIVMqgMDPS-----ALEALINFAYNGHLAIDQQNVQSLLMGASFL 142
Cdd:cd18217   25 IGQFQFKAHRNVLAAFSEYFGAQY-----KDTEDNIVF--LDQSqvsadGFQKLLEFIYTGNLNLDSWNVAEIHQAASYL 97


                 ....*....
gi 686585569 143 QLQNIKDAC 151
Cdd:cd18217   98 GMEEVVAKC 106

BTB_POZ_ZBTB7B_ZBTB15

cd18327

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

72-156

2.47e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7B (ZBTB7B); ZBTB7B is also called Krueppel-related zinc finger protein cKrox, T-helper-inducing POZ/Krueppel-like factor, zinc finger and BTB domain-containing protein 15 (ZBTB15), zinc finger protein 67 (ZNF67), Zfp67, zinc finger protein 857B (ZNF857B), or zinc finger protein Th-POK. It is a transcriptional regulator of extracellular matrix gene expression. It plays widespread and critical roles in T-cell development, particularly as the master regulator of CD4 commitment. It also plays a role as a potent driver of brown fat development and thermogenesis, as well as cold-induced beige fat formation. ZBTB7B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349636 [Multi-domain] Cd Length: 127 Bit Score: 52.54 E-value: 2.47e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569  72 KFSAHRIVLAASIPYFHAMFTNDMMECK-------QDEIVMQGMDPSALEALINFAYNGHLAIDQQNVQSLLMGASFLQL 144
Cdd:cd18327   36 EYRTHRAVLAACSLYFRKLFTGGGGGSGdlgagggQDVCELDFVGPEALGALLEFAYTATLTISSSNMREVLRAARLLEI 115

                         90
                 ....*....|..
gi 686585569 145 QNIKDACCTFLR 156
Cdd:cd18327  116 PCVADACADILQ 127

BTB_POZ_ZBTB19_PATZ1

cd18207

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

67-151

2.66e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in POZ-, AT hook-, and zinc finger-containing protein 1 (PATZ1); PATZ1 is also called zinc finger and BTB domain-containing protein 19 (ZBTB19), BTB/POZ domain zinc finger transcription factor, protein kinase A RI subunit alpha-associated protein, zinc finger protein 278, or zinc finger sarcoma gene protein. It is an important transcriptional regulatory factor that regulates divergent pathways depending on the cellular context. For instance, it acts as a transcriptional suppressor that functions in T lymphocytes. It is also a DNA damage-responsive transcription factor that inhibits p53 function. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349516 [Multi-domain] Cd Length: 128 Bit Score: 52.66 E-value: 2.66e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569  67 RVGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQD-EIVMQGMDPSALEALINFAYNGHLAIDQQNVQSLLMGASFLQLQ 145
Cdd:cd18207   33 RVGEESFPAHRAVLAACSEYFESVFSAQEGDGGTPrELEMHTISSKVFGDILDFAYTSRIVVRLESFPELMTAAKFLLMR 112


                 ....*.
gi 686585569 146 NIKDAC 151
Cdd:cd18207  113 SVIDIC 118

BTB_POZ_ZBTB18_2-like

cd18325

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

68-158

3.48e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18.2 and similar proteins; This subfamily is composed of Xenopus laevis zinc finger and BTB domain-containing protein 18.2, encoded by the znf238.2.L gene, and similar proteins. Many proteins in this group are annotated as zinc finger and BTB domain-containing protein 42 (ZBTB42). However, characterized mammalian ZBTB42 does not belong to this subfamily. ZBTB18.2, like ZBTB18, functions as a transcriptional repressor that plays a role in various developmental processes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349634 [Multi-domain] Cd Length: 128 Bit Score: 52.35 E-value: 3.48e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569  68 VGDHKFSAHRIVLAASIPYFHaMFTNDMMEckQDEIVMQGMD---PSALEALINFAYNGHLAIDQQNVQSLLMGASFLQL 144
Cdd:cd18325   30 VGEAQFRAHRAVLASCSMYFH-LFYRDQLD--KRDIVHLNSDivtAPAFSLLLEFMYEGKLEFSSLPVEDVLAAASYLHM 106

                         90
                 ....*....|....
gi 686585569 145 QNIKDACCTFLRER 158
Cdd:cd18325  107 YDIVKVCKGKLKDK 120

BTB_POZ_ZBTB45

cd18229

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

67-158

4.74e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 45 (ZBTB45); ZBTB45, also called zinc finger protein 499 (ZNF499), may act as a transcriptional regulator that is essential for proper glial differentiation of neural and oligodendrocyte progenitor cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349538 [Multi-domain] Cd Length: 112 Bit Score: 51.40 E-value: 4.74e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569  67 RVGDHKFSAHRIVLAASIPYFHamftnDMMECKQDEIVMQGMDPS-ALEALINFAYNGHLAIDQQNVQSLLMGASFLQLQ 145
Cdd:cd18229   24 RIHDASLRAHRCVLAAGSPFFH-----DKLLLGHSEIEVPPVVPAqTVRQLVEFMYSGSLVVAQSEALQILTAASILQIK 98

                         90
                 ....*....|...
gi 686585569 146 NIKDACCTFLRER 158
Cdd:cd18229   99 TVIDECTQIISQS 111

BTB_POZ_TDPOZ

cd18344

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

68-123

6.77e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in TD and POZ domain-containing proteins (TDPOZ); TDPOZ is a family of bipartite animal and plant proteins that contains a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domain. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. This subfamily contains only mammalian members. Plant TDPOZ proteins contain a MATH domain at the N-terminal region and are named "BTB/POZ and MATH domain-containing proteins (BPM)", not included in this subfamily. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349653 [Multi-domain] Cd Length: 128 Bit Score: 51.50 E-value: 6.77e-08

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 686585569  68 VGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNG 123
Cdd:cd18344   30 VAGHEFRAHKAILAARSPVFRAMFEHEMEERLKNPIEIHDLDPQVFKEMMGFIYTG 85

BACK_KLHL14

cd18453

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 14 (KLHL14); KLHL14, also ...

165-269

7.22e-08

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 14 (KLHL14); KLHL14, also termed protein interactor of Torsin-1A, or Printor, or protein interactor of torsinA, is a novel ATP-free form of torsinA-interacting protein implicated in dystonia pathogenesis.

Pssm-ID: 350528 Cd Length: 102 Bit Score: 50.79 E-value: 7.22e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569 165 LGVRQFAETMMCAVLY--DAANSFIHQHFVEvsmseEFLALPFEDVLELVSRDELNVKSEEQVFEAALAWIRYDRDQRES 242
Cdd:cd18453    1 ISVQNYKQVCKIAALHglEETKKLANKYLVE-----DVLLLNFEEMRAMLDSLPPPVESELALFQMSVLWLEHDRETRMQ 75

                         90       100
                 ....*....|....*....|....*..
gi 686585569 243 FLPELLSKIRLPLCRPQFLTDRVQQDD 269
Cdd:cd18453   76 YAPDLMKRLRFALIPAPELVERVQSVD 102

Kelch_6

Kelch motif;

307-350

8.78e-08

Kelch motif;

Pssm-ID: 404790 [Multi-domain] Cd Length: 50 Bit Score: 48.87 E-value: 8.78e-08

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 686585569  307 CTSIAGLIYAVGGLNSAGDSLNVVEVFDPIANRWEKCQPMTTAR 350
Cdd:pfam13964   7 VVSVGGYIYVFGGYTNASPALNKLEVYNPLTKSWEELPPLPTPR 50

BTB_POZ_BTBD1

cd18346

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

69-163

9.57e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 1 (BTBD1); BTBD1, also called Hepatitis C virus NS5A-transactivated protein 8 or HCV NS5A-transactivated protein 8, is a BTB-domain-containing Kelch-like protein that is expressed in skeletal muscle and interacts with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. BTBD1 may serve as substrate-specific adaptor of an E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349655 [Multi-domain] Cd Length: 133 Bit Score: 51.21 E-value: 9.57e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569  69 GDHKFSAHRIVLAASIPYFHAMFtNDMMECKQDEIVMQGMDPSALEALINFAYNGHLAIDQQNVQSLLMGASFLQLQNIK 148
Cdd:cd18346   40 GAQRIPAHRFVLAAGSAVFDAMF-NGGMATTSAEIELPDVEPAAFLALLRFLYSDEVQIGPETVMTTLYTAKKYAVPALE 118

                         90
                 ....*....|....*
gi 686585569 149 DACCTFLRERLHPKN 163
Cdd:cd18346  119 AHCVEFLTKHLRADN 133

BTB_POZ_SPOP

cd18342

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

68-163

1.00e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP); SPOP, also called HIB homolog 1 or Roadkill homolog 1, is a novel nuclear speckle-type protein which serves as an adaptor of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and proteasomal degradation of target proteins, such as BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349651 [Multi-domain] Cd Length: 125 Bit Score: 50.87 E-value: 1.00e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569  68 VGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGHLAIDQQNVQSLLMGASFLQLQNI 147
Cdd:cd18342   29 VAGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVEPEVFKEMMCFIYTGKAPNLDKMADDLLAAADKYALERL 108

                         90
                 ....*....|....*.
gi 686585569 148 KDACCTFLRERLHPKN 163
Cdd:cd18342  109 KVMCEDALCSNLSVEN 124

Kelch_1

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...

303-347

1.52e-07

Pssm-ID: 396078 [Multi-domain] Cd Length: 46 Bit Score: 47.99 E-value: 1.52e-07

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 686585569  303 RPRCCTSIAGLIYAVGGLNSaGDSLNVVEVFDPIANRWEKCQPMT 347
Cdd:pfam01344   3 SGAGVVVVGGKIYVIGGFDG-NQSLNSVEVYDPETNTWSKLPSMP 46

BACK_KBTBD6_7

cd18482

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing ...

163-252

1.70e-07

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing proteins, KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling.

Pssm-ID: 350557 [Multi-domain] Cd Length: 99 Bit Score: 49.42 E-value: 1.70e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569 163 NCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLA-LPFEDVLELVSRDELNVKSEEQVFEAALAWIRYDRDQRE 241
Cdd:cd18482    5 NCAGILKFADAFDNRELKSKALAFIARNFQQLLAKEEELCeLSLAQLKEVLMLDSLDVDSERKVCSVAVQWIEANLKERA 84

                         90
                 ....*....|.
gi 686585569 242 SFLPELLSKIR 252
Cdd:cd18482   85 ASAAEVLKCVR 95

BTB1_POZ_RhoBTB

cd18299

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

69-155

2.32e-07

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. In vertebrates, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349608 [Multi-domain] Cd Length: 103 Bit Score: 49.13 E-value: 2.32e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569  69 GDHKFSAHRIVLAASIPYFHAMFTNdMMECKQDEIVmqgmDPSALEALINFAYNGHLAIDQQNVQSLLMGASFLQLQNIK 148
Cdd:cd18299   21 GGVRIFAHRIVLAAASSVFADLFLM-MTVVTLDSDI----TPEAFRRVLEFLYTGVLDENEDDLKELKDAAELLELFDLV 95


                 ....*..
gi 686585569 149 DACCTFL 155
Cdd:cd18299   96 MMCTNVL 102

BTB_POZ_ZBTB35_ZNF131

cd18221

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

68-145

2.36e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger protein 131 (ZNF131); ZNF131, also called zinc finger and BTB domain-containing protein 35 (ZBTB35), is a transcriptional activator implicated as a regulator of Kaiso-mediated biological processes. It regulates cell growth of developing and mature T cells. It inhibits estrogen signaling by suppressing estrogen receptor alpha homo-dimerization, and plays a role in breast cancer cell proliferation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349530 [Multi-domain] Cd Length: 113 Bit Score: 49.61 E-value: 2.36e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569  68 VGDHKFSAHRIVLAASIPYFHAMFtndmMECKQDEIV-MQGMDPSALEALINFAYNGHLAI-DQQNVQSLLMGASFLQLQ 145
Cdd:cd18221   25 VDGHQFKAHKAVLAACSQFFYKFF----QDFTQEPLVeIEGVSNMAFRHLIEFTYTAKLMVqGEEEANDVWKAAEYLQMQ 100

BTB_POZ_BTBD2

cd18347

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

65-163

2.46e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 2 (BTBD2); BTBD2 is a BTB-domain-containing Kelch-like protein that interacts with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349656 [Multi-domain] Cd Length: 127 Bit Score: 50.07 E-value: 2.46e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569  65 GNRVGDHKFSAHRIVLAASIPYFHAMFtNDMMECKQDEIVMQGMDPSALEALINFAYNGHLAIDQQNVQSLLMGASFLQL 144
Cdd:cd18347   30 GKGLGSQRIPAHRFVLAVGSAVFDAMF-NGGMATTSTEIELPDVEPAAFLALLKFLYSDEVQIGPETVMTTLYTAKKYAV 108

                         90
                 ....*....|....*....
gi 686585569 145 QNIKDACCTFLRERLHPKN 163
Cdd:cd18347  109 PALEAHCVEFLKKNLRADN 127

Kelch_6

Kelch motif;

397-440

2.51e-07

Kelch motif;

Pssm-ID: 404790 [Multi-domain] Cd Length: 50 Bit Score: 47.33 E-value: 2.51e-07

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 686585569  397 RSAMGTVVLDGQIYVCGGY-DGNSSLNSVESYSPETNKWTVVTPM 440
Cdd:pfam13964   2 RTFHSVVSVGGYIYVFGGYtNASPALNKLEVYNPLTKSWEELPPL 46

BTB_POZ_ZBTB27_BCL6

cd18331

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

68-155

2.73e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 protein (BCL-6); BCL-6 is also called B-cell lymphoma 5 protein (BCL-5), zinc finger and BTB domain-containing protein 27 (ZBTB27), protein LAZ-3, or zinc finger protein 51 (ZNF51). It is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. It represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' or indirectly by repressing the transcriptional activity of transcription factors. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349640 [Multi-domain] Cd Length: 118 Bit Score: 49.47 E-value: 2.73e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569  68 VGDHKFSAHRIVLAASIPYFHAMFTnDMMECKQDEIVMQ-GMDPSALEALINFAYNGHLAIDQQNVQSLLMGASFLQLQN 146
Cdd:cd18331   31 VSREQFRAHKTVLMACSGLFYSIFT-DQLKCNLSVINLDpEINPEGFNILLDFMYTSRLNLREGNIMAVMATAMYLQMEH 109


                 ....*....
gi 686585569 147 IKDACCTFL 155
Cdd:cd18331  110 VVDTCRKFI 118

BTB_POZ_ZBTB27-like

cd18215

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

68-154

3.32e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 proteins, BCL-6 and BCL-6B; This family includes B-cell lymphoma 6 proteins, BCL-6 and BCL-6B. BCL-6 is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. BCL-6B is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349524 [Multi-domain] Cd Length: 113 Bit Score: 49.10 E-value: 3.32e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569  68 VGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGHLAIDQQNVQSLLMGASFLQLQNI 147
Cdd:cd18215   26 VGREQFRAHKTVLMACSGLFYSIFTDQLKNNVSVINLDPEIEPEGFRILLDFMYTSRLNLREGNIMAVMATAMYLQMEHV 105


                 ....*..
gi 686585569 148 KDACCTF 154
Cdd:cd18215  106 VDTCRKF 112

BTB_POZ_ZBTB28_BCL6B

cd18332

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

67-156

3.47e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell CLL/lymphoma 6 member B protein (BCL6B); BCL6B is also called Bcl6-associated zinc finger protein, zinc finger protein 62, or zinc finger and BTB domain-containing protein 28 (ZBTB28). It is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. BCL6B plays an important role as a potential tumor suppressor in gastric cancer; it is found preferentially methylated in gastric cancer. It also inhibits both colorectal cancer growth and hepatocellular carcinoma metastases. BCL6B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349641 [Multi-domain] Cd Length: 114 Bit Score: 49.08 E-value: 3.47e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569  67 RVGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGHLAIDQQNVQSLLMGASFLQLQN 146
Cdd:cd18332   25 LVGGTPLRAHKAVLIACSGFFYSIFSGRVGEGVSVLTLPSGLEARGFQLLLDFMYTSRLPLTPRTVPAVLAAATYLQMEH 104

                         90
                 ....*....|
gi 686585569 147 IKDACCTFLR 156
Cdd:cd18332  105 VVETCRRFIQ 114

BTB_POZ_ZBTB5

cd18196

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

68-161

3.86e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 5 (ZBTB5); ZBTB5 is a POZ domain Kruppel-like zinc finger (POK) family transcription repressor of cell cycle arrest gene p21 and a potential proto-oncogene stimulating cell proliferation. ZBTB5 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349505 [Multi-domain] Cd Length: 126 Bit Score: 49.28 E-value: 3.86e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569  68 VGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQG--MDPSALEALINFAYNGHLAIDQQNVQSLLMGASFLQLQ 145
Cdd:cd18196   28 VGNRHFKAHRSVLAACSTHFRALFTVAEGDQTMNMIQLDSevVTAEAFAALIDMMYTSTLMLGESNVMDVLLAASHLHLN 107

                         90
                 ....*....|....*.
gi 686585569 146 NIKDACCTFLRERLHP 161
Cdd:cd18196  108 SVVKACKHYLTTRTLP 123

BACK_KLHL32_BKLHD5

cd18471

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also ...

163-255

3.90e-07

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also termed BTB and kelch domain-containing protein 5 (BKLHD5), belongs to the KLHL family. Its function remains unclear. KLHL32 SNPs may be associated with body mass index in individuals of African ancestry.

Pssm-ID: 350546 [Multi-domain] Cd Length: 98 Bit Score: 48.36 E-value: 3.90e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569 163 NCLGVRQFAETMMCAVLYDAANSFIHQHFVEV--SMSEEFLALPFEDVLELVSRDELNVKSEEQVFEAALAWIRYdrDQR 240
Cdd:cd18471    5 NYLDLYKLADLFNLTLLEEAVVDFLVKHLSELlkSHPEEVLALPYRLLREVLKSDRLTSLSEEQIWQLAVRWLEH--NCR 82

                         90
                 ....*....|....*
gi 686585569 241 ESFLPELLSKIRLPL 255
Cdd:cd18471   83 YQYMDELLQYVRFGL 97

BTB_POZ_ZBTB8

cd18199

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

73-155

4.08e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8 (ZBTB8); There are two ZBTB8 isoforms: ZBTB8A and ZBTB8B. ZBTB8A is a novel proto-oncoprotein that stimulates cell proliferation. ZBTB8B may be involved in transcriptional regulation. They both contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349508 [Multi-domain] Cd Length: 113 Bit Score: 48.96 E-value: 4.08e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569  73 FSAHRIVLAASIPYFHAMFTNDMMECKQDEIV-MQGMDPSALEALINFAYNGHLAIDQQNVQSLLMGASFLQLQNIKDAC 151
Cdd:cd18199   30 FKAHRNVLFASSGYFRMLLSHYIQDTGRPSTAsFDVFSSDAFSIILDFVYSGKLSLTSQNVIEVMSAASYLQMTDVINVC 109


                 ....
gi 686585569 152 CTFL 155
Cdd:cd18199  110 KTFI 113

BTB_POZ_ARIA_plant

cd18352

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...

72-151

5.36e-07

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant ARM repeat protein interacting with ABF2 (ARIA) and similar proteins; ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2, a transcription factor which controls ABA-dependent gene expression via the G-box-type ABA-responsive elements. ARIA is a novel abscisic acid signaling component. It negatively regulates seed germination and young seedling growth. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349661 [Multi-domain] Cd Length: 116 Bit Score: 48.63 E-value: 5.36e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569  72 KFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGHLAIDQQNVQSLLMGASFLQLQNIKDAC 151
Cdd:cd18352   24 RFYAHRIALLASSDAFRAMFDGGYREKEARDIEIPNIRWEVFELMMRFIYTGSVDITNDIAKDLLRAADQYLLEGLKRLC 103

PLN02193

nitrile-specifier protein

350-546

6.86e-07

nitrile-specifier protein

Pssm-ID: 177844 [Multi-domain] Cd Length: 470 Bit Score: 51.88 E-value: 6.86e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569 350 RSRVGVAVVNGLLYAIGG--YDGQLRLSTVEVYNPEMDSWSKVESMNS--KRSAMGT--VVLDGQIYVCGGYDGNSSLNS 423
Cdd:PLN02193 166 RCSHGIAQVGNKIYSFGGefTPNQPIDKHLYVFDLETRTWSISPATGDvpHLSCLGVrmVSIGSTLYVFGGRDASRQYNG 245

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569 424 VESYSPETNKWTVVTPMSSN---RSAAGVTVFEGRIYVSGGHDGLQIFNSVEYYNHHTATWHPVASMLNKRCRHGAASL- 499
Cdd:PLN02193 246 FYSFDTTTNEWKLLTPVEEGptpRSFHSMAADEENVYVFGGVSATARLKTLDSYNIVDKKWFHCSTPGDSFSIRGGAGLe 325

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 686585569 500 --GSKMFVCGGYDGSGFLSIaEVYSSMADQWYLIVPMNSRRSRVSLVAN 546
Cdd:PLN02193 326 vvQGKVWVVYGFNGCEVDDV-HYYDPVQDKWTQVETFGVRPSERSVFAS 373

BTB_POZ_ZBTB30_HIC2

cd18334

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

73-151

6.91e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 2 protein (Hic-2); Hic-2 is also called HIC1-related gene on chromosome 22 protein (HRG22), Hic-3, or zinc finger and BTB domain-containing protein 30 (ZBTB30). It is a homolog of tumor suppressor Hic-1. It functions as a transcriptional regulator. It is a dosage-dependent regulator of cardiac development located within the distal 22q11 deletion syndrome region. Hic-2 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349643 [Multi-domain] Cd Length: 120 Bit Score: 48.42 E-value: 6.91e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569  73 FSAHRIVLAASIPYFHAMFTNDMMECKQDEIVmqgmDPSALEALINFAYNGH-LAIDQ---QNVQSLLMGASFLQLQNIK 148
Cdd:cd18334   33 FRAHKNILAASSMYFKSLVLHDNLINLDTDMV----NPTVFRQILDFIYTGKlLTSDQpgeQNFNALLTAASYLQLHDLA 108


                 ...
gi 686585569 149 DAC 151
Cdd:cd18334  109 ALC 111

PLN02153

epithiospecifier protein

350-529

9.72e-07

epithiospecifier protein

Pssm-ID: 177814 [Multi-domain] Cd Length: 341 Bit Score: 51.14 E-value: 9.72e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569 350 RSRVGVAVVNGLLYAIGG-------YDGQLRlstveVYNPEMDSWS---------KVESMNSKRSAMGTvvldgQIYVCG 413
Cdd:PLN02153  23 RCSHGIAVVGDKLYSFGGelkpnehIDKDLY-----VFDFNTHTWSiapangdvpRISCLGVRMVAVGT-----KLYIFG 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569 414 GYDGNSSLNSVESYSPETNKWTVVTPMSSN-----RSAAGVTVFEGRIYVSGG--HDGLQI----FNSVEYYNHHTATWH 482
Cdd:PLN02153  93 GRDEKREFSDFYSYDTVKNEWTFLTKLDEEggpeaRTFHSMASDENHVYVFGGvsKGGLMKtperFRTIEAYNIADGKWV 172

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 686585569 483 PV---ASMLNKRCRHGAASLGSKMFVCGGYDGSGFLSIAEVYSSMADQWY 529
Cdd:PLN02153 173 QLpdpGENFEKRGGAGFAVVQGKIWVVYGFATSILPGGKSDYESNAVQFF 222

Kelch

Kelch domain;

502-546

9.91e-07

Kelch domain;

Pssm-ID: 128874 [Multi-domain] Cd Length: 47 Bit Score: 45.63 E-value: 9.91e-07

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 686585569   502 KMFVCGGYDGSGFLSIAEVYSSMADQWYLIVPMNSRRSRVSLVAN 546
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVI 45

BTB2_POZ_ABTB1_BPOZ1

cd18296

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

67-155

1.30e-06

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349605 [Multi-domain] Cd Length: 121 Bit Score: 47.68 E-value: 1.30e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569  67 RVGDHKFSAHRIVLAASIPYFHAMFTNDMMEC-----KQDEIVMQGMDPSALEALINFAYNGHLAIDQQNVQSLLMGASF 141
Cdd:cd18296   23 QVEGHRFPCHKAFFCGRSDYFKALLRDHFAESeenngSIPVVTLHDVSPEVFAIVLYYIYTDDTDLPPENAYDVLYVADM 102

                         90
                 ....*....|....
gi 686585569 142 LQLQNIKDACCTFL 155
Cdd:cd18296  103 YLLPGLKRLCGTVL 116

BTB1_POZ_ABTB1_BPOZ1

cd18295

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

72-149

1.42e-06

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349604 [Multi-domain] Cd Length: 119 Bit Score: 47.24 E-value: 1.42e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569  72 KFSAHRIVLAASIPYFHAMFTNdmmECK-QDEIVMQG--MDPSALEALINFAYNGHLAIDQQNVQSLLMGASFLQLQNIK 148
Cdd:cd18295   30 SFPAHRCILSARSPYFAEMFET---KWKdKREINLKHplVNPDAFRALLQYLYTGRLEIHVDDVEDCKRLAKQCRLEELI 106


                 .
gi 686585569 149 D 149
Cdd:cd18295  107 E 107

Kelch_2

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...

537-581

1.45e-06

Pssm-ID: 462220 [Multi-domain] Cd Length: 47 Bit Score: 45.40 E-value: 1.45e-06

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 686585569  537 RRSRVSLVANCGRLYAVGGYDGQSNLSSVEM--YDPETNRWTFMAPM 581
Cdd:pfam07646   1 PRYPHASSVPGGKLYVVGGSDGLGDLSSSDVlvYDPETNVWTEVPRL 47

BTB_POZ_ETO1-like

cd18190

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...

67-140

1.65e-06

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Arabidopsis thaliana ethylene-overproduction protein 1 (ETO1) and similar proteins; ETO1, also called protein ethylene overproducer 1, is an essential regulator of the ethylene pathway, which acts by regulating the stability of 1-aminocyclopropane-1-carboxylate synthase (ACS) enzymes. It may act as a substrate-specific adaptor that connects ACS enzymes, such as ACS5, to ubiquitin ligase complexes, leading to proteasomal degradation of ACS enzymes. The family also includes ETO1-like proteins 1 (EOL1) and 2 (EOL2). ETO1, EOL1, and EOL2 contain a BTB domain and tetratricopeptide (TPR) repeats. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349499 [Multi-domain] Cd Length: 83 Bit Score: 46.35 E-value: 1.65e-06

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 686585569  67 RVGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQ--GMDPSALEALINFAYNGHL-AIDQQNVQSLLMGAS 140
Cdd:cd18190    5 CVGGEKFCCVRKKIASLSRPFKAMLYGNFRESTSDCIDFEenGISIEAMRAVIDFSVTGRLdLFSVENVHEVLELAS 81

BTB_POZ_ZBTB1

cd18192

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

68-149

1.68e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 1 (ZBTB1); ZBTB1 acts as a transcriptional repressor that represses cAMP-responsive element (CRE)-mediated transcriptional activation. It also has a role in translesion DNA synthesis, and is essential for lymphocyte development. ZBTB1 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349501 [Multi-domain] Cd Length: 114 Bit Score: 47.12 E-value: 1.68e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569  68 VGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGHLAIDQQNVQSLLMGASFLQLQNI 147
Cdd:cd18192   28 IDDIYFQAHKAVLAACSSYFRMMFINHQHTTAQLNLSNMKISAECFDLILQFMYLGKIMTAPSDFEQLKVAMNYLQLYYI 107


                 ..
gi 686585569 148 KD 149
Cdd:cd18192  108 PE 109

BTB_POZ_BTBD18

cd18293

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

74-151

2.47e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 18 (BTBD18); BTBD18 acts as a specific controller for transcription activation through RNA polymerase II elongation at a subset of genomic PIWI-interacting RNA (piRNA) loci. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349602 [Multi-domain] Cd Length: 120 Bit Score: 46.71 E-value: 2.47e-06

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 686585569  74 SAHRIVLAASIPYFHAMFTNDMM-ECKQDEIVMQGMDPSALEALINFAYNGHLAIDQQNVQSLLMGASFLQLQNIKDAC 151
Cdd:cd18293   28 PAHCCVLSACSPYLTERLSSEPPpAGQKVVLELQGLKAHTLLKLVDFLYTSELEVSSEEAQDVLAAARRLQISELESLC 106

BTB_POZ_BTBD3

cd18348

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

69-163

2.58e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 3 (BTBD3); BTBD3 is a BTB-domain-containing Kelch-like protein that controls dendrite orientation toward active axons in the mammalian neocortex. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349657 [Multi-domain] Cd Length: 131 Bit Score: 46.94 E-value: 2.58e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569  69 GDHKFSAHRIVLAASIPYFHAMFTNDMMECKqDEIVMQGMDPSALEALINFAYNGHLAIDQQNVQSLLMGASFLQLQNIK 148
Cdd:cd18348   33 GTQRLPGHKYVLAVGSSVFHAMFYGELAEDK-DEIRIPDVEPAAFLAMLKYIYCDEIDLAADTVLATLYAAKKYIVPHLA 111

                         90
                 ....*....|....*
gi 686585569 149 DACCTFLRERLHPKN 163
Cdd:cd18348  112 RACVNFLETSLSAKN 126

BTB_POZ_ZBTB48_TZAP_KR3

cd18232

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

55-154

2.85e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in telomere zinc finger-associated protein (TZAP); TZAP is also called Krueppel-related zinc finger protein 3 (KR3), zinc finger and BTB domain-containing protein 48 (ZBTB48), or zinc finger protein 855 (ZNF855). It is a vertebrate telomere-binding protein involved in telomere length control. It directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. TZAP also acts as a transcription regulator that binds to promoter regions. It is a transcriptional activator of alternate reading frame (ARF) gene. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349541 [Multi-domain] Cd Length: 108 Bit Score: 46.29 E-value: 2.85e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569  55 RDASSYCVHTGNrVGDHKFSAHRIVLAASIPYFHAMFTNDMmeckQDEIVMQGMDPSALEALINFAYNGHLAIDQQNVQS 134
Cdd:cd18232   13 REEGQYCDATLD-VGGRVFKAHWSVLACCSHFFQSLYGDGT----SGSVVLPESFAEVFGLLLDFFYTGELALTRENRDR 87

                         90       100
                 ....*....|....*....|
gi 686585569 135 LLMGASFLQLQNIKDACCTF 154
Cdd:cd18232   88 VLLAAKELRVPEAVELCQRF 107

BTB_POZ_BTBD3_6

cd18282

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

65-159

3.67e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD3 and BTBD6; This family includes BTB/POZ domain-containing proteins BTBD3 and BTBD6, both of which are BTB-domain-containing Kelch-like proteins. BTBD3 controls dendrite orientation toward active axons in mammalian neocortex. BTBD6 is required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349591 [Multi-domain] Cd Length: 108 Bit Score: 45.85 E-value: 3.67e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569  65 GNRVGDHKFSAHRIVLAASIPYFHAMFTNDMMEcKQDEIVMQGMDPSALEALINFAYNGHLAIDQQNVQSLLMGASFLQL 144
Cdd:cd18282   15 GPPGGTQRIPAHKYVLATGSSVFYAMFYGGLAE-NKNEIEIPDVEPAAFLNLLRYLYCDEIDLEPDTVLATLYAAKKYLV 93

                         90
                 ....*....|....*
gi 686585569 145 QNIKDACCTFLRERL 159
Cdd:cd18282   94 PHLARACVQFLETSL 108

BTB_POZ_ZBTB23_GZF1

cd18211

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

56-151

4.32e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in glial cell line-derived neurotrophic factor-inducible zinc finger protein 1 (GZF1); GZF1 is also called GDNF-inducible zinc finger protein 1, zinc finger and BTB domain-containing protein 23 (ZBTB23), or zinc finger protein 336 (ZNF336). It is a sequence-specific transcriptional repressor that binds the GZF1 responsive element (GRE), with the consensus sequence of 5'-TGCGCN[TG][CA]TATA-3'. It may play a role in renal branching morphogenesis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349520 [Multi-domain] Cd Length: 128 Bit Score: 46.39 E-value: 4.32e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569  56 DASSYCVHTGNRvgdHKFSAHRIVLAASIPYFHAMFTNDM-MECKQDEIVMQGMDPSALEALINFAYNGHLAIDQQNVQS 134
Cdd:cd18211   27 DVTVQVEHQGSK---EEFSAHKAVLAASSKYFKEVFLNEKiSDGKNTNVMLNEIYTADFASFLEFVYTAKVEVEEDRVQR 103

                         90
                 ....*....|....*..
gi 686585569 135 LLMGASFLQLQNIKDAC 151
Cdd:cd18211  104 MLEIAEKLKCLDLSETC 120

BTB_POZ_BTBD6

cd18349

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

69-159

5.99e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 6 (BTBD6); BTBD6, also termed lens BTB domain protein, is a BTB-domain-containing Kelch-like protein required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349658 [Multi-domain] Cd Length: 109 Bit Score: 45.36 E-value: 5.99e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569  69 GDHKFSAHRIVLAASIPYFHAMFTNDMMECKQdEIVMQGMDPSALEALINFAYNGHLAIDQQNVQSLLMGASFLQLQNIK 148
Cdd:cd18349   20 ASQRVPAHKYVLAVGSSVFYAMFYGDLAEVKS-EIHIPDVEPAAFLILLKYMYSDEIDLEADTVLATLYAAKKYIVPALA 98

                         90
                 ....*....|.
gi 686585569 149 DACCTFLRERL 159
Cdd:cd18349   99 KACVNFLETSL 109

Kelch_2

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...

397-440

6.75e-06

Pssm-ID: 462220 [Multi-domain] Cd Length: 47 Bit Score: 43.48 E-value: 6.75e-06

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 686585569  397 RSAMGTVVLDGQIYVCGGYDGN--SSLNSVESYSPETNKWTVVTPM 440
Cdd:pfam07646   2 RYPHASSVPGGKLYVVGGSDGLgdLSSSDVLVYDPETNVWTEVPRL 47

BACK_KBTBD4

cd18481

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...

162-249

6.75e-06

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 4 (KBTBD4); KBTBD4, also termed BTB and kelch domain-containing protein 4 (BKLHD4), is a BTB-BACK-Kelch domain protein belonging to a large family of cullin-RING ubiquitin ligase adaptors that facilitate the ubiquitination of target substrates.

Pssm-ID: 350556 Cd Length: 88 Bit Score: 44.49 E-value: 6.75e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569 162 KNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPFEDVLELVSRdelNVKSEEQVFEAALAWIRYDRDQRE 241
Cdd:cd18481    4 RNCLQVMWLADQHSDQELYTAAKHCAKTHLSQLHQTEEFLNLPLRLLTDIIKD---GVPCSQNPTAAIEAWINHNKEERE 80


                 ....*...
gi 686585569 242 SFLPELLS 249
Cdd:cd18481   81 GFSETLTS 88

BTB1_POZ_IBtk

cd18301

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

67-123

7.14e-06

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349610 [Multi-domain] Cd Length: 99 Bit Score: 44.97 E-value: 7.14e-06

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 686585569  67 RVGDHKFSAHRIVLAASIPYFHAMFTNDMMEC----KQDEIVMQGMDPSALEALINFAYNG 123
Cdd:cd18301   24 QVGGKTFPAHKFILASRSDYFRKLFLSSLLTSedavGCDVVHIEKVPPEIFEQLLQFIYTD 84

BTB_POZ_ZBTB10

cd18201

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

73-160

8.08e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 10 (ZBTB10); ZBTB10, also called zinc finger protein RIN ZF, is an mRNA target of miR-27a and a transcriptional repressor of Specificity protein (Sp) expression. The microRNA-27a:ZBTB10-specificity protein pathway is involved in follicle stimulating hormone-induced VEGF, Cox2, and survivin expression in ovarian epithelial cancer cells. ZBTB10 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349510 [Multi-domain] Cd Length: 122 Bit Score: 45.33 E-value: 8.08e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569  73 FSAHRIVLAASIPYFHAMFTNDMMEcKQDEIVMQGMDPSALEA---LINFAYNGHLAIDQQNVQSLLMGASFLQLQNIKD 149
Cdd:cd18201   33 FRAHKNILVAGSRFFKTLYCFTNKE-SCDQTTVTHLDVVAVQGfsvILDFMYSGNLVLTSQNAIEVMSVASYLQMTEVVQ 111

                         90
                 ....*....|.
gi 686585569 150 ACCTFLRERLH 160
Cdd:cd18201  112 SCRNFIKDALN 122

BTB_POZ_ZBTB39

cd18224

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

68-151

8.57e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 39 (ZBTB39); ZBTB39 may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349533 [Multi-domain] Cd Length: 123 Bit Score: 45.21 E-value: 8.57e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569  68 VGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVmQGMDPSALEALINFAYNGHLAIDQQNVQSLLMGASFLQLQNI 147
Cdd:cd18224   33 VGNRSFAAHKAVLACAAGYFQKLFLSTELDVARTYVV-DFITPANFEKVLSFIYTSELFTDLINVGVIYEVAEKLGMEDL 111


                 ....
gi 686585569 148 KDAC 151
Cdd:cd18224  112 LKAC 115

BTB_POZ_KLHL42

cd18319

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

67-143

8.57e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 42 (KLHL42); KLHL42, also called Cullin-3-binding protein 9 (Ctb9) or Kelch domain-containing protein 5, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL42) E3 ubiquitin ligase complex mediates the ubiquitination and subsequent degradation of katanin (KATNA1). KLHL42 is involved in microtubule dynamics throughout mitosis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349628 [Multi-domain] Cd Length: 93 Bit Score: 44.48 E-value: 8.57e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569  67 RVGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGHLAIDQQN----------VQSLL 136
Cdd:cd18319    7 RLEDRCYNVSKRKLIEQSDYFRALYRSGMRESGEEVVQLRGLSAPGLELVLDFINTSKVHESQGDstdtleenelLEDLV 86


                 ....*..
gi 686585569 137 MGASFLQ 143
Cdd:cd18319   87 EAASFLQ 93

PLN02193

nitrile-specifier protein

382-576

1.10e-05

nitrile-specifier protein

Pssm-ID: 177844 [Multi-domain] Cd Length: 470 Bit Score: 48.03 E-value: 1.10e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569 382 PEMDSWSKVESMNSK---RSAMGTVVLDGQIYVCGG-YDGNSSLNS-VESYSPETNKWTVvTPMSS---NRSAAGVTVFE 453
Cdd:PLN02193 148 KLLGKWIKVEQKGEGpglRCSHGIAQVGNKIYSFGGeFTPNQPIDKhLYVFDLETRTWSI-SPATGdvpHLSCLGVRMVS 226

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569 454 --GRIYVSGGHDGLQIFNSVEYYNHHTATWH---PVASMLNKRCRHGAASLGSKMFVCGGYDGSGFLSIAEVYSSMADQW 528
Cdd:PLN02193 227 igSTLYVFGGRDASRQYNGFYSFDTTTNEWKlltPVEEGPTPRSFHSMAADEENVYVFGGVSATARLKTLDSYNIVDKKW 306

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 686585569 529 Y-LIVPMNSRRSR--VSLVANCGRLYAVGGYDGqSNLSSVEMYDPETNRWT 576
Cdd:PLN02193 307 FhCSTPGDSFSIRggAGLEVVQGKVWVVYGFNG-CEVDDVHYYDPVQDKWT 356

PRK14131

N-acetylneuraminate epimerase;

396-469

1.32e-05

N-acetylneuraminate epimerase;

Pssm-ID: 237617 [Multi-domain] Cd Length: 376 Bit Score: 47.70 E-value: 1.32e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569 396 KRSAMGTVVLDGQIYVCGGYDGNSS------LNSVESYSPETNKWTVV---TPMSSNrSAAGVTVFEGRIYVSGGHDgLQ 466
Cdd:PRK14131  74 PREQAVAAFIDGKLYVFGGIGKTNSegspqvFDDVYKYDPKTNSWQKLdtrSPVGLA-GHVAVSLHNGKAYITGGVN-KN 151


                 ...
gi 686585569 467 IFN 469
Cdd:PRK14131 152 IFD 154

Kelch_6

Kelch motif;

538-581

1.56e-05

Kelch motif;

Pssm-ID: 404790 [Multi-domain] Cd Length: 50 Bit Score: 42.32 E-value: 1.56e-05

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 686585569  538 RSRVSLVANCGRLYAVGGYDGQSNLSS-VEMYDPETNRWTFMAPM 581
Cdd:pfam13964   2 RTFHSVVSVGGYIYVFGGYTNASPALNkLEVYNPLTKSWEELPPL 46

BTB_POZ_ZBTB32_FAZF_TZFP

cd18218

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

55-151

1.82e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 32 (ZBTB32); ZBTB32 is also called FANCC-interacting protein, fanconi anemia zinc finger protein (FAZF), testis zinc finger protein (TZFP), or zinc finger protein 538 (ZNF538). It is a DNA-binding transcription factor that binds to the 5'-TGTACAGTGT-3' core sequence. It acts as a transcription suppressor that controls T cell-mediated autoimmunity. ZBTB32 is essential for down-regulation of GATA3 via ZPO2; this promotes aggressive breast cancer development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349527 [Multi-domain] Cd Length: 110 Bit Score: 44.16 E-value: 1.82e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569  55 RDASSYCvHTGNRVGDHKFSAHRIVLAASIPYFHAMFTNdmmECKQDEIVMQGMDPSALEALINFAYNGHLAIDQQNVQS 134
Cdd:cd18218   13 RPAGALC-DTLITVGSQEFPAHSLVLAGASQQLGRQLTN---PNPGQWCLGEGISPSTFKQLLDFVYGESVEVQPGELRP 88

                         90
                 ....*....|....*..
gi 686585569 135 LLMGASFLQLQNIKDAC 151
Cdd:cd18218   89 LLEAARALEVESLEEAC 105

Kelch_6

Kelch motif;

349-397

1.90e-05

Kelch motif;

Pssm-ID: 404790 [Multi-domain] Cd Length: 50 Bit Score: 42.32 E-value: 1.90e-05

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 686585569  349 ARSRVGVAVVNGLLYAIGGYDGQL-RLSTVEVYNPEMDSWSKVESMNSKR 397
Cdd:pfam13964   1 PRTFHSVVSVGGYIYVFGGYTNASpALNKLEVYNPLTKSWEELPPLPTPR 50

BTB_POZ_KBTBD13

cd18320

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

67-108

2.42e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 13 (KBTBD13); KBTBD13 is a muscle specific protein. Its autosomal dominant mutations may cause Nemaline Myopathy (NEM). KBTBD13 may act as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that functions as a muscle specific ubiquitin ligase, and thereby implicating the ubiquitin proteasome pathway in the pathogenesis of KBTBD13-associated NEM. KBTBD13 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349629 [Multi-domain] Cd Length: 83 Bit Score: 42.80 E-value: 2.42e-05

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 686585569  67 RVGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGM 108
Cdd:cd18320    7 WVEEQLFTVDKALLVENSEYFRALFRSGMRECTQDEIRLQGL 48

BTB_POZ_CP190-like

cd18311

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...

60-143

2.42e-05

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster centrosomal protein 190kD (CP190) and similar proteins; CP190 is a large, multi-domain protein, first identified as a centrosome protein with oscillatory localization over the course of the cell cycle. It has an essential function in the nucleus as a chromatin insulator. It is known to associate with the nuclear matrix, components of the RNAi machinery, active promoters and borders of the repressive chromatin domains. CP190 contains an N-terminal BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349620 [Multi-domain] Cd Length: 110 Bit Score: 43.73 E-value: 2.42e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569  60 YCVHTGNRVGDHKFSAHRIVLAASIPYFHAMftNDMMECKQDEIVMQG-MDPSALEALINFAYNGHLAIDQQNVQSLLMG 138
Cdd:cd18311   14 YCDLTLQFRDNEQLKVHRLVLSACTDYFNVL--EQTCEIVDDTLIMPNeLQADAVVPVINFMYTGQLEFEEKSYGKLLRT 91


                 ....*
gi 686585569 139 ASFLQ 143
Cdd:cd18311   92 AKELN 96

BTB_POZ_ZBTB20_DPZF

cd18208

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

67-151

2.85e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 20 (ZBTB20); ZBTB20, also called dendritic-derived BTB/POZ zinc finger protein (DPZF) or zinc finger protein 288, may be a transcription factor involved in hematopoiesis, oncogenesis, and immune responses. It is an essential regulator of hepatic lipogenesis and may be a therapeutic target for the treatment of fatty liver disease. It also functions as a critical regulator of anterior pituitary development and lactotrope specification. Moreover, it promotes astrocytogenesis during neocortical development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349517 [Multi-domain] Cd Length: 117 Bit Score: 43.51 E-value: 2.85e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569  67 RVGDHKFSAHRIVLAASIPYFHamftNDMMECKQDEIVMQGMDPSALEALINFAYNGHLAIDQQNVQSLLMGASFLQLQN 146
Cdd:cd18208   31 RIHGSMLRAHRCVLAAGSPFFQ----DKLLLGYSDIEIPSVVSVQSVQKLIDFMYSGVLRVSQSEALQILTAASILQIKT 106


                 ....*
gi 686585569 147 IKDAC 151
Cdd:cd18208  107 VIDEC 111

BTB2_POZ_LZTR1

cd18309

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

68-123

3.87e-05

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1); LZTR-1 is a golgi BTB-kelch protein that is degraded upon induction of apoptosis. It may also function as a transcriptional regulator that plays a crucial role in embryogenesis. Germline loss-of-function mutations in LZTR-1 predispose to an inherited disorder of multiple schwannomas. LZTR-1 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349618 [Multi-domain] Cd Length: 126 Bit Score: 43.53 E-value: 3.87e-05

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 686585569  68 VGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPS--ALEALINFAYNG 123
Cdd:cd18309   27 LDGHPIPAHKAILAARCSYFEAMFRSFMPEDNTVNISIGEMVPSrqAFDSLLRYIYYG 84

PLN02153

epithiospecifier protein

491-587

4.30e-05

epithiospecifier protein

Pssm-ID: 177814 [Multi-domain] Cd Length: 341 Bit Score: 46.13 E-value: 4.30e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569 491 RCRHGAASLGSKMFVCGGYDGSGFLSIAEVYS-SMADQWYLIVPMNSRRSRVS-----LVANCGRLYAVGGYDGQSNLSS 564
Cdd:PLN02153  23 RCSHGIAVVGDKLYSFGGELKPNEHIDKDLYVfDFNTHTWSIAPANGDVPRISclgvrMVAVGTKLYIFGGRDEKREFSD 102

                         90       100
                 ....*....|....*....|...
gi 686585569 565 VEMYDPETNRWTFMAPMVcHEGG 587
Cdd:PLN02153 103 FYSYDTVKNEWTFLTKLD-EEGG 124

BTB_POZ_BTBD14A_NAC2

cd18289

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

68-147

4.30e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 2 (NAC-2); NAC-2, also called BTB/POZ domain-containing protein 14A (BTBD14A) or repressor with BTB domain and BEN domain (RBB), is a novel transcription repressor through its association with the NuRD complex. It recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349598 [Multi-domain] Cd Length: 131 Bit Score: 43.48 E-value: 4.30e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569  68 VGDHKFSAHRIVLAASIPYFHAMFTNDmmeCKQDEIVMQGMDPSALEALINFAYNGHLAIDQQNVQSLLMGASFLQLQNI 147
Cdd:cd18289   36 VKGQAFKAHRAVLAASSLYFRDLFSGN---SKSAFELPATVPPACFQQILSFCYTGKLTMAASEQLVVMYTAGFLQIQHI 112

BTB_POZ_ZBTB29-like

cd18216

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

73-151

4.73e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer proteins, Hic-1 and Hic-2; The family includes hypermethylated in cancer proteins, Hic-1 and Hic-2. Hic-1 is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. Hic-2 is a homolog of tumor suppressor Hic-1 that functions as a transcriptional regulator. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349525 [Multi-domain] Cd Length: 118 Bit Score: 42.91 E-value: 4.73e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569  73 FSAHRIVLAASIPYFHAM-FTNDMMECKQDeivmqGMDPSALEALINFAYNGHLA---IDQQNVQSLLMGASFLQLQNIK 148
Cdd:cd18216   32 FRAHKNVLAASSGYFKSLvLHDNLIHLDQD-----MVSPTVFQQILDFIYTGKLLdslFEEPNLSEVLAAANYLQLPDLA 106


                 ...
gi 686585569 149 DAC 151
Cdd:cd18216  107 ALC 109

BACK_KLHL36

cd18475

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act ...

184-255

5.62e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Pssm-ID: 350550 Cd Length: 100 Bit Score: 42.52 E-value: 5.62e-05

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 686585569 184 NSFIHQHFVEVSMSEEFLA-LPFEDVLELVSRDELNVKSEEQVFEAALAWIRyDRDQRESFLPELLSKIRLPL 255
Cdd:cd18475   26 DSFILQNFGTLSFTPDFLQnVSMQKLCQYLSSNQVQHECEHDLLQAALQWLT-QSPERENEAYQVLSNIHFPL 97

BTB_POZ_ZBTB8B

cd18330

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

73-155

5.69e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8B (ZBTB8B); ZBTB8B may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349639 [Multi-domain] Cd Length: 113 Bit Score: 42.61 E-value: 5.69e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569  73 FSAHRIVLAASIPYFHAMFTNDMMEC-KQDEIVMQGMDPSALEALINFAYNGHLAIDQQNVQSLLMGASFLQLQNIKDAC 151
Cdd:cd18330   30 FKAHRNILFANSGYFRALLIHYIQDSgRHSTASLDIVTSEAFSIILDFLYSGKLDLCSENVIEVMSAASYLQMTDVVNFC 109


                 ....
gi 686585569 152 CTFL 155
Cdd:cd18330  110 KGYI 113

Kelch_3

pfam13415

Galactose oxidase, central domain;

406-452

7.73e-05

Galactose oxidase, central domain;

Pssm-ID: 433188 [Multi-domain] Cd Length: 49 Bit Score: 40.35 E-value: 7.73e-05

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 686585569  406 DGQIYVCGGYD--GNSSLNSVESYSPETNKWTVVTPMSSNRSAAGVTVF 452
Cdd:pfam13415   1 GDKLYIFGGLGfdGQTRLNDLYVYDLDTNTWTQIGDLPPPRSGHSATYI 49

BTB_POZ_ZBTB41

cd18226

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

58-142

1.01e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 41 (ZBTB41); ZBTB41, also called FRBZ1, may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349535 [Multi-domain] Cd Length: 114 Bit Score: 42.09 E-value: 1.01e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569  58 SSYCVHTGNRVGDHkFSAHRIVLAASIPYFHAMFTNDMmecKQDEIVMQGMDPSALEALINFAYNGHLAIDQQNVQSLLM 137
Cdd:cd18226   20 SSFCDLVITVEGKE-FSAHKVVVAVGSSYFHACLSKNP---NTDAVTLDHVSYSVFQHLLEFLYTSEFFVYENEIPLVLE 95


                 ....*
gi 686585569 138 GASFL 142
Cdd:cd18226   96 AAKFL 100

BTB_POZ_ZBTB29_HIC1

cd18333

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

73-151

1.63e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 1 protein (Hic-1); Hic-1, also called zinc finger and BTB domain-containing protein 29 (ZBTB29), is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. It may act as a tumor suppressor, and is involved in regulatory loops modulating P53-dependent and E2F1-dependent cell survival, growth control, and stress responses. It also regulates intestinal immunity and homeostasis. Hic-1 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349642 [Multi-domain] Cd Length: 121 Bit Score: 41.43 E-value: 1.63e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569  73 FSAHRIVLAASIPYFHAMFTNDMMECKQDEIVmqgmDPSALEALINFAYNGHLA----IDQQNVQSLLMGASFLQLQNIK 148
Cdd:cd18333   33 FRAHKNILAASSVYLKSLVVHDNLINLDHEMV----SPGIFRLILDYIYTGRLSegdpGSEQNLGAVLAAASYLQIPDLV 108


                 ...
gi 686585569 149 DAC 151
Cdd:cd18333  109 ALC 111

BACK_KLHL15

cd18454

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 15 (KLHL15); KLHL15 is a ...

184-258

1.71e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 15 (KLHL15); KLHL15 is a substrate-specific adaptor for Cullin3 E3 ubiquitin-protein ligase complex that target the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits. It also plays a key role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR), by targeting the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation.

Pssm-ID: 350529 Cd Length: 108 Bit Score: 41.03 E-value: 1.71e-04

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 686585569 184 NSFIHQHFVEVSMSEEFLA-LPFEDVLELVSRDELNVKSEEQVFEAALAWIRYDRdQRESFLPELLSKIRLPLCRP 258
Cdd:cd18454   28 DSFLLENFVPLMSRPDFLSyLSFEKLMSYLDNDHLSRFPEIELYEAVQAWLRHDR-RRWRHTDTIIQNIRFCLMTP 102

BACK_GPRS_like

cd18507

BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster serine-enriched ...

171-234

3.10e-04

BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster serine-enriched protein (GPRS) and similar proteins; The family includes uncharacterized Drosophila melanogaster serine-enriched protein (GPRS) and similar proteins.

Pssm-ID: 350582 Cd Length: 80 Bit Score: 39.80 E-value: 3.10e-04

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 686585569 171 AETMMCAVLydaanSFIHQHFVEVSMSEEFLALPfEDVLELV-SRDELNVkSEEQVFEAALAWIR 234
Cdd:cd18507   21 TKTLVQKVL-----EFVDKHGTDVLNLPEFLLLP-EHVVRLIlSRDSLGA-DEMTKFQAALAWSR 78

Kelch_4

pfam13418

Galactose oxidase, central domain;

398-440

3.97e-04

Galactose oxidase, central domain;

Pssm-ID: 433191 [Multi-domain] Cd Length: 49 Bit Score: 38.36 E-value: 3.97e-04

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 686585569  398 SAMGTVVLDGQIYVCGGYDGNSS-LNSVESYSPETNKWTVVTPM 440
Cdd:pfam13418   4 YHTSTSIPDDTIYLFGGEGEDGTlLSDLWVFDLSTNEWTRLGSL 47

PLN02193

nitrile-specifier protein

396-575

4.21e-04

nitrile-specifier protein

Pssm-ID: 177844 [Multi-domain] Cd Length: 470 Bit Score: 43.02 E-value: 4.21e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569 396 KRSAMGTVVLDGQIYvcgGYDGNSS--LNSVESY--SPET----NKWTVVTPMSSN---RSAAGVTVFEGRIYVSGGH-- 462
Cdd:PLN02193 110 KRPGVKFVLQGGKIV---GFHGRSTdvLHSLGAYisLPSTpkllGKWIKVEQKGEGpglRCSHGIAQVGNKIYSFGGEft 186

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569 463 DGLQIFNSVEYYNHHTATWH--------PVASMLNKRcrhgAASLGSKMFVCGGYDGS----GFLSiaevYSSMADQWYL 530
Cdd:PLN02193 187 PNQPIDKHLYVFDLETRTWSispatgdvPHLSCLGVR----MVSIGSTLYVFGGRDASrqynGFYS----FDTTTNEWKL 258

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 686585569 531 IVPMN---SRRSRVSLVANCGRLYAVGGYDGQSNLSSVEMYDPETNRW 575
Cdd:PLN02193 259 LTPVEegpTPRSFHSMAADEENVYVFGGVSATARLKTLDSYNIVDKKW 306

BACK_BTBD17

cd18493

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 17 (BTBD17); ...

169-233

5.14e-04

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also termed galectin-3-binding protein-like, is a BTB-domain-containing Kelch-like protein. Its function remains unclear. It may be involved in hepatocellular carcinoma development and progression.

Pssm-ID: 350568 Cd Length: 74 Bit Score: 38.71 E-value: 5.14e-04

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 686585569 169 QFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPFEDVLELVSRDELNVKSEEQVFEAALAWI 233
Cdd:cd18493   10 QYAKMCGHKELAEACLEFIAWNFEKVLKSPDWLNLDLDLLVSLLQSSDLVVEDEYTLFQAVEKWL 74

Kelch_2

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...

350-393

7.42e-04

Pssm-ID: 462220 [Multi-domain] Cd Length: 47 Bit Score: 37.70 E-value: 7.42e-04

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 686585569  350 RSRVGVAVVNGLLYAIGGYDGQLRLS--TVEVYNPEMDSWSKVESM 393
Cdd:pfam07646   2 RYPHASSVPGGKLYVVGGSDGLGDLSssDVLVYDPETNVWTEVPRL 47

PLN02153

epithiospecifier protein

314-449

9.31e-04

epithiospecifier protein

Pssm-ID: 177814 [Multi-domain] Cd Length: 341 Bit Score: 41.90 E-value: 9.31e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569 314 IYAVGGLNsAGDSLNVVEVFDPIANRWEKCQPMTT-----ARSRVGVAVVNGLLYAIGGYD-GQL-----RLSTVEVYNP 382
Cdd:PLN02153  88 LYIFGGRD-EKREFSDFYSYDTVKNEWTFLTKLDEeggpeARTFHSMASDENHVYVFGGVSkGGLmktpeRFRTIEAYNI 166

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 686585569 383 EMDSWSKVESMN---SKRSAMGTVVLDGQIYVCGGYdGNSSL---------NSVESYSPETNKWTVVTPMSSNRSAAGV 449
Cdd:PLN02153 167 ADGKWVQLPDPGenfEKRGGAGFAVVQGKIWVVYGF-ATSILpggksdyesNAVQFFDPASGKWTEVETTGAKPSARSV 244

BTB_POZ_ZBTB11

cd18202

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

72-151

9.97e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 11 (ZBTB11); ZBTB11 is a transcriptional repressor of TP53. It is critical for basal and emergency granulopoiesis. It regulates neutrophil development through its integrase-like zinc finger domain. ZBTB11 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349511 [Multi-domain] Cd Length: 118 Bit Score: 39.45 E-value: 9.97e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569  72 KFSAHRIVLAASIPYFHAMFTNDMMECKQDEIV-MQGMDPSALEALINFAYNGHLAIDQQNVQSLLMGASFLQLQNIKDA 150
Cdd:cd18202   30 EYKAHKSVLAANSEYFRELFIEKGAVSSHEAVVdLSGFCKSSFLPLLEFAYTSELTFDFCSMAEVAMLARHLFMNEVLEI 109


                 .
gi 686585569 151 C 151
Cdd:cd18202  110 C 110

Kelch_3

pfam13415

Galactose oxidase, central domain;

312-351

1.18e-03

Galactose oxidase, central domain;

Pssm-ID: 433188 [Multi-domain] Cd Length: 49 Bit Score: 37.27 E-value: 1.18e-03

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 686585569  312 GLIYAVGGLN-SAGDSLNVVEVFDPIANRWEKCQPMTTARS 351
Cdd:pfam13415   2 DKLYIFGGLGfDGQTRLNDLYVYDLDTNTWTQIGDLPPPRS 42

Kelch_2

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...

304-346

1.44e-03

Pssm-ID: 462220 [Multi-domain] Cd Length: 47 Bit Score: 36.93 E-value: 1.44e-03

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 686585569  304 PRCCTSIAGL---IYAVGGLNSAGD-SLNVVEVFDPIANRWEKCQPM 346
Cdd:pfam07646   1 PRYPHASSVPggkLYVVGGSDGLGDlSSSDVLVYDPETNVWTEVPRL 47

BACK_KLHL34

cd18473

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 34 (KLHL34); KLHL34 belongs ...

159-261

1.68e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 34 (KLHL34); KLHL34 belongs to the KLHL family. Its function remains unclear. The methylation status of KLHL34 cg14232291 may be a predictive candidate of sensitivity to preoperative chemoradiation therapy.

Pssm-ID: 350548 Cd Length: 106 Bit Score: 38.18 E-value: 1.68e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569 159 LHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSE----EFLALPFEDVLELVSRDELNVKSEEQVFEAALAWIR 234
Cdd:cd18473    1 LSPENCCFSANIAARFGLPDALKAAEKYIISNLWRLLASDaddaGLLELNLESLQAVLEADDIPRVKESRLLTLVLEWLN 80

                         90       100
                 ....*....|....*....|....*..
gi 686585569 235 YDrDQRESFLPELLSKIRLPLCRPQFL 261
Cdd:cd18473   81 QD-ESRLAYANALLSRIRYGLVPVEEL 106

BTB_POZ_ZBTB14

cd18204

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

68-157

1.84e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 14 (ZBTB14); ZBTB14 is also called zinc finger protein 161 (Zfp-161), zinc finger protein 478, zinc finger protein 5 (ZF5), or Zfp-5. It is a novel transcriptional activator of the dopamine transporter, binding it's promoter at the consensus sequence 5'-CCTGCACAGTTCACGGA-3'. It also binds to 5'-d(GCC)(n)-3' trinucleotide repeats in promoter regions and acts as a repressor of the FMR1 gene. ZBTB14 acts as a transcriptional repressor of MYC and thymidine kinase promoters. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349513 [Multi-domain] Cd Length: 114 Bit Score: 38.48 E-value: 1.84e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686585569  68 VGDHKFSAHRIVLAASIPYFHAMFTNdmMECKQDEIV-MQGMDPSALEALINFAYNGHLAIDQQNVQSLLMGASFLQLQN 146
Cdd:cd18204   25 VEDVKFRAHRCVLAACSTYFKKLFKK--LEVDSSSVIeIDFLRSDIFEEVLNYMYTAKISVKKEDVNLMMSSGQILGIRF 102

                         90
                 ....*....|.
gi 686585569 147 IkDACCTFLRE 157
Cdd:cd18204  103 L-DKLCSQKRD 112

Kelch_6