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Conserved domains on  [gi|688596668|ref|XP_009291820|]
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zinc finger protein 143 isoform X1 [Danio rerio]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
244-417 2.57e-13

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 72.42  E-value: 2.57e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688596668 244 AHHLKVHERSHTGdKPYICDHLGCGKKFATGYGLKSHVRT--HTGE--KPYRCQELNCLKSFKTSGDLQKHTRTHTGEKP 319
Cdd:COG5048  273 SSPNESDSSSEKG-FSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYSLCGKLFSRNDALKRHILLHTSISP 351

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688596668 320 FKCPFEGCGRSFTTSNIRK-----VHIRTHTGERPYYCAEPNCGRAFASATNYKNHMRIHTGEKPYVCTVPGCDKRFT-E 393
Cdd:COG5048  352 AKEKLLNSSSKFSPLLNNEppqslQQYKDLKNDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCKNPPCSKSFNrH 431

                        170       180
                 ....*....|....*....|....*
gi 688596668 394 YSSlyKHHVVHTPCK-PYNCNHCGK 417
Cdd:COG5048  432 YNL--IPHKKIHTNHaPLLCSILKS 454
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
244-417 2.57e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 72.42  E-value: 2.57e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688596668 244 AHHLKVHERSHTGdKPYICDHLGCGKKFATGYGLKSHVRT--HTGE--KPYRCQELNCLKSFKTSGDLQKHTRTHTGEKP 319
Cdd:COG5048  273 SSPNESDSSSEKG-FSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYSLCGKLFSRNDALKRHILLHTSISP 351

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688596668 320 FKCPFEGCGRSFTTSNIRK-----VHIRTHTGERPYYCAEPNCGRAFASATNYKNHMRIHTGEKPYVCTVPGCDKRFT-E 393
Cdd:COG5048  352 AKEKLLNSSSKFSPLLNNEppqslQQYKDLKNDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCKNPPCSKSFNrH 431

                        170       180
                 ....*....|....*....|....*
gi 688596668 394 YSSlyKHHVVHTPCK-PYNCNHCGK 417
Cdd:COG5048  432 YNL--IPHKKIHTNHaPLLCSILKS 454
zf-H2C2_2 pfam13465
Zinc-finger double domain;
306-333 1.09e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 42.36  E-value: 1.09e-05
                          10        20
                  ....*....|....*....|....*...
gi 688596668  306 DLQKHTRTHTGEKPFKCPFegCGRSFTT 333
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPE--CGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
244-417 2.57e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 72.42  E-value: 2.57e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688596668 244 AHHLKVHERSHTGdKPYICDHLGCGKKFATGYGLKSHVRT--HTGE--KPYRCQELNCLKSFKTSGDLQKHTRTHTGEKP 319
Cdd:COG5048  273 SSPNESDSSSEKG-FSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYSLCGKLFSRNDALKRHILLHTSISP 351

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688596668 320 FKCPFEGCGRSFTTSNIRK-----VHIRTHTGERPYYCAEPNCGRAFASATNYKNHMRIHTGEKPYVCTVPGCDKRFT-E 393
Cdd:COG5048  352 AKEKLLNSSSKFSPLLNNEppqslQQYKDLKNDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCKNPPCSKSFNrH 431

                        170       180
                 ....*....|....*....|....*
gi 688596668 394 YSSlyKHHVVHTPCK-PYNCNHCGK 417
Cdd:COG5048  432 YNL--IPHKKIHTNHaPLLCSILKS 454
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
290-447 7.72e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 70.88  E-value: 7.72e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688596668 290 YRCQELNCLKSFKTSGDLQKHTRT--HTGE--KPFKCPFEGCGRSFTTSNIRKVHIRTHTGERPYYCAEPNCGRAFASAT 365
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLL 367

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688596668 366 NYKNH-----MRIHTGEKPYVCTVPGCDKRFTEYSSLYKHHVVHTPCKPYNCN--HCGKTYKQISTLAMHKRTAHNdTEP 438
Cdd:COG5048  368 NNEPPqslqqYKDLKNDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTN-HAP 446


                 ....*....
gi 688596668 439 IEEEQEGYF 447
Cdd:COG5048  447 LLCSILKSF 455
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
348-423 1.56e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 60.48  E-value: 1.56e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 688596668 348 RPYYCaePNCGRAFASATNYKNHMRIHTGEKPYVCTVPGCDKRFTEYSSLYKHHVVHTPCKPYNCNHCGKTYKQIS 423
Cdd:COG5048   32 RPDSC--PNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKA 105
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 366-433 1.66e-07

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 53.95  E-value: 1.66e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688596668 366 NYKNHMRIHTGEKPYVCTVPGCDKRFTEYSSLyKHHVVHTPC--------------------KPYNCNHCGKTYKQISTL 425
Cdd:COG5189  336 DTPSRMLKVKDGKPYKCPVEGCNKKYKNQNGL-KYHMLHGHQnqklhenpspekmnifsakdKPYRCEVCDKRYKNLNGL 414


                 ....*...
gi 688596668 426 AMHKRTAH 433
Cdd:COG5189  415 KYHRKHSH 422
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
219-370 2.83e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 53.16  E-value: 2.83e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688596668 219 SPRIQHVGE--KAFRCEHEGCGKLYTTAHHLKVHERSHTGDKPYICDHLGCGKKF---ATGYGLKSHV--RTHTGEKPYR 291
Cdd:COG5048  309 LRSVNHSGEslKPFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFsplLNNEPPQSLQqyKDLKNDKKSE 388

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 688596668 292 CQELNCLKSFKTSGDLQKHTRTHTGEKPFKCPFEGCGRSFTTSNIRKVHIRTHTGERPYYCaepNCGRAFASATNYKNH 370
Cdd:COG5048  389 TLSNSCIRNFKRDSNLSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLC---SILKSFRRDLDLSNH 464
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 316-405 1.91e-06

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 50.49  E-value: 1.91e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688596668 316 GEKPFKCPFEGCGRSFTTSNIRKVH-IRTHTGERPYYCAEPNCGRAFASAtnyknhmrihtgEKPYVCTVpgCDKRFTEY 394
Cdd:COG5189  346 DGKPYKCPVEGCNKKYKNQNGLKYHmLHGHQNQKLHENPSPEKMNIFSAK------------DKPYRCEV--CDKRYKNL 411

                         90
                 ....*....|.
gi 688596668 395 SSLyKHHVVHT 405
Cdd:COG5189  412 NGL-KYHRKHS 421
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 216-285 4.33e-06

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 49.33  E-value: 4.33e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688596668 216 DCRSPRIQHVGEKAFRCEHEGCGKLYTTAHHLKVH---------------ERSHTG----DKPYICDHlgCGKKFATGYG 276
Cdd:COG5189  336 DTPSRMLKVKDGKPYKCPVEGCNKKYKNQNGLKYHmlhghqnqklhenpsPEKMNIfsakDKPYRCEV--CDKRYKNLNG 413


                 ....*....
gi 688596668 277 LKSHvRTHT 285
Cdd:COG5189  414 LKYH-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
306-333 1.09e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 42.36  E-value: 1.09e-05
                          10        20
                  ....*....|....*....|....*...
gi 688596668  306 DLQKHTRTHTGEKPFKCPFegCGRSFTT 333
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPE--CGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
277-303 3.12e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.20  E-value: 3.12e-05
                          10        20
                  ....*....|....*....|....*..
gi 688596668  277 LKSHVRTHTGEKPYRCQElnCLKSFKT 303
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPE--CGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
366-392 3.72e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.82  E-value: 3.72e-05
                          10        20
                  ....*....|....*....|....*..
gi 688596668  366 NYKNHMRIHTGEKPYVCTVpgCDKRFT 392
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPE--CGKSFK 25
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
303-414 5.94e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.84  E-value: 5.94e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688596668 303 TSGDLQKHTRTHTGE----KPFKCPFegCGRSFTTSNIRKVHIRTHTGERPYYCAEPNCGRAFASATNYKNHMRIHTGEK 378
Cdd:COG5048   13 NSVLSSTPKSTLKSLsnapRPDSCPN--CTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHHNNP 90

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 688596668 379 PYVCTVPGC----DKRFTEYSSLYKHHVVHTPCKPYNCNH 414
Cdd:COG5048   91 SDLNSKSLPlsnsKASSSSLSSSSSNSNDNNLLSSHSLPP 130
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
257-320 8.26e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.46  E-value: 8.26e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 688596668 257 DKPYICDhlGCGKKFATGYGLKSHVRTHTGEKPYRCQELNCLKSFKTSGDLQKHTRTHTGEKPF 320
Cdd:COG5048   31 PRPDSCP--NCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHHNNPSD 92
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
288-366 8.70e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.46  E-value: 8.70e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 688596668 288 KPYRCqeLNCLKSFKTSGDLQKHTRTHTGEKPFKCPFEGCGRSFTTSNIRKVHIRTHTGERPYYCAEPNCGRAFASATN 366
Cdd:COG5048   32 RPDSC--PNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSS 108
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
246-443 2.22e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.92  E-value: 2.22e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688596668 246 HLKVHERSHTGDKPYICDHLGCGKKFATGYGLKSHVRTHTGEKPYRCQELNCLKSFKTSGDL------------------ 307
Cdd:COG5048   48 HLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSlsssssnsndnnllsshs 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688596668 308 ----QKHTRTHTGEKP---FKCPFEGCGRSFT----TSNIRKVHIRTHTGERPYYCAEPNCGRAFASA--TNYKNHMRIH 374
Cdd:COG5048  128 lppsSRDPQLPDLLSIsnlRNNPLPGNNSSSVntpqSNSLHPPLPANSLSKDPSSNLSLLISSNVSTSipSSSENSPLSS 207

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 688596668 375 TGEKPYVCTVPGCDKRFTEYSSLYKHHVVH---------TPCKPYNCNHCGKTYKQISTLAMHKRTAHNDTEPIEEEQ 443
Cdd:COG5048  208 SYSIPSSSSDQNLENSSSSLPLTTNSQLSPksllsqspsSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSSSEKG 285
zf-C2H2_8 pfam15909
C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.
 262-349 4.51e-04

C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.


Pssm-ID: 464935 [Multi-domain]  Cd Length: 98  Bit Score: 39.71  E-value: 4.51e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688596668  262 CDHLGCGKKFATGYGLKSHVRTHTGE------KPYRCQELNCLKSFKTSGDLQKHTRTH-TGEKPFKCpfEGCGRSFTT- 333
Cdd:pfam15909   2 CSSPGCCLSFPSVRDLAQHLRTHCPPtqslegKLFRCSALSCTETFPSMQELVAHSKLHyKPNRYFKC--ENCLLRFRTh 79

                          90
                  ....*....|....*..
gi 688596668  334 -SNIRKVHIRTHTGERP 349
Cdd:pfam15909  80 rSLFKHLHVCAEHAQSP 96
zf-H2C2_2 pfam13465
Zinc-finger double domain;
338-363 1.07e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.07e-03
                          10        20
                  ....*....|....*....|....*.
gi 688596668  338 KVHIRTHTGERPYYCaePNCGRAFAS 363
Cdd:pfam13465   3 KRHMRTHTGEKPYKC--PECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
246-273 2.19e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.19e-03
                          10        20
                  ....*....|....*....|....*...
gi 688596668  246 HLKVHERSHTGDKPYICDHlgCGKKFAT 273
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPE--CGKSFKS 26
zf-C2H2_8 pfam15909
C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.
 352-428 9.81e-03

C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.


Pssm-ID: 464935 [Multi-domain]  Cd Length: 98  Bit Score: 35.86  E-value: 9.81e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688596668  352 CAEPNCGRAFASATNYKNHMRIHTGE------KPYVCTVPGCDKRFTEYSSLYKHHVVH-TPCKPYNCNHCGKTYKQIST 424
Cdd:pfam15909   2 CSSPGCCLSFPSVRDLAQHLRTHCPPtqslegKLFRCSALSCTETFPSMQELVAHSKLHyKPNRYFKCENCLLRFRTHRS 81


                  ....
gi 688596668  425 LAMH 428
Cdd:pfam15909  82 LFKH 85
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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