|
Name |
Accession |
Description |
Interval |
E-value |
| SM-ATX |
pfam14438 |
Ataxin 2 SM domain; This SM domain is found in Ataxin-2. |
63-136 |
7.09e-20 |
|
Ataxin 2 SM domain; This SM domain is found in Ataxin-2.
Pssm-ID: 464173 Cd Length: 78 Bit Score: 84.91 E-value: 7.09e-20
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 688555903 63 MVHVLTSVVGTKCELKVKNGLIYEGVFKTYGPE--CDIVLDAAHRKSVEPNAG--PRREDIVESIIFKSSDVVVVHFK 136
Cdd:pfam14438 1 LLFLLTSLVGLVVEVTTKNGEVYEGIFSTASLEkdFGVVLKMARRIKKSNGSGlnPVRGEIVDTMIFPAKDIVDIEAK 78
|
|
| LsmAD |
pfam06741 |
LsmAD domain; This domain is found associated with Lsm domain. |
209-270 |
8.56e-17 |
|
LsmAD domain; This domain is found associated with Lsm domain.
Pssm-ID: 461998 [Multi-domain] Cd Length: 65 Bit Score: 75.69 E-value: 8.56e-17
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 688555903 209 YGVKSTYDSSLssYTVPLERdNSEEFLKREARASQLAEEIEASATYKARVALENDDR------SEEEK 270
Cdd:pfam06741 1 FGVKSTYDENL--YTTKLDR-SSPDYKEREAEAERIAREIEGSASTNAHVAEERGLDvddsglDEEDK 65
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
655-1079 |
3.30e-07 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 54.94 E-value: 3.30e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688555903 655 SAGSKAGTPSLSPSSAVPEQKRGPDVTSQGVQTTSPLANAVTKdKDEKEDKNDPVAESVRKSTLNPNAKEFNPRVFCSPP 734
Cdd:PHA03247 2581 AVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHA-PDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPG 2659
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688555903 735 KPATTPTLTRPQGQPSPSIVVQQP------PTVYGQTMFQMYPLTPVSPGVQPPAMYH-VQVPHMTMSQTKSYRSGKVQN 807
Cdd:PHA03247 2660 RVSRPRRARRLGRAAQASSPPQRPrrraarPTVGSLTSLADPPPPPPTPEPAPHALVSaTPLPPGPAAARQASPALPAAP 2739
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688555903 808 MPQQRPDQHHPPGTSTMMHS-ATAAGPPIVAPSPAYSTqyftcSPQQFASQPLVqqmphyqsqaqhvfSPVIQGSARMIT 886
Cdd:PHA03247 2740 APPAVPAGPATPGGPARPARpPTTAGPPAPAPPAAPAA-----GPPRRLTRPAV--------------ASLSESRESLPS 2800
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688555903 887 PPTHAQPSLVSSSTTQygeqthTMYVSQTPIPQQFPHPSSTLHPHPQHPQPSATPTgQPQQGTQHGGSHPAPSPVQHQQH 966
Cdd:PHA03247 2801 PWDPADPPAAVLAPAA------ALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSL-PLGGSVAPGGDVRRRPPSRSPAA 2873
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688555903 967 QAAAAAAAQAIHLGNPQQQQMYSALAATPPSMTPGPNPQSPQASFPSAQQAvyihpqhgynpnhmahvQQAHMQSGMVPP 1046
Cdd:PHA03247 2874 KPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPP-----------------PPPQPQPPPPPP 2936
|
410 420 430
....*....|....*....|....*....|...
gi 688555903 1047 HHGNPSHPPTMMLMATQAPAGPQPALPQGTLNP 1079
Cdd:PHA03247 2937 PRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVP 2969
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
830-1075 |
9.99e-07 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 53.23 E-value: 9.99e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688555903 830 AAGPPIVAPSPAYSTQYFTCSPQQFASQPLVQQMPH-YQSQAQHVFSPVIQGSARMITPPTHAQPSLVSSSTTQYGEQTH 908
Cdd:pfam03154 143 STSPSIPSPQDNESDSDSSAQQQILQTQPPVLQAQSgAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQ 222
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688555903 909 TMYVSQTPI-------PQQFPHPSSTLHPHPQHPQPSATPTGQPQQGTQHGGSHPAPSPVQHQQHQAAAAAAAQAIHLGN 981
Cdd:pfam03154 223 STAAPHTLIqqtptlhPQRLPSPHPPLQPMTQPPPPSQVSPQPLPQPSLHGQMPPMPHSLQTGPSHMQHPVPPQPFPLTP 302
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688555903 982 PQQQQM------------YSALAATPPSMTPGPNPQSP--QASFPSAQQAVYIHP------------QHGYNPNHMAHVQ 1035
Cdd:pfam03154 303 QSSQSQvppgpspaapgqSQQRIHTPPSQSQLQSQQPPreQPLPPAPLSMPHIKPppttpipqlpnpQSHKHPPHLSGPS 382
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 688555903 1036 QAHMQSGMVPP-----------HHGNPSHPPTMMLMATQAPAGPQPALPQG 1075
Cdd:pfam03154 383 PFQMNSNLPPPpalkplsslstHHPPSAHPPPLQLMPQSQQLPPPPAQPPV 433
|
|
| PABP-1234 |
TIGR01628 |
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ... |
879-998 |
1.33e-03 |
|
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.
Pssm-ID: 130689 [Multi-domain] Cd Length: 562 Bit Score: 42.87 E-value: 1.33e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688555903 879 QGSARMITPPthaQPSLVSssTTQYGEQTHTMYVSQTPIPQQFPHPSSTLHPHPQHPQPSATPTG---QPQQGTQHGGSH 955
Cdd:TIGR01628 377 QLQPRMRQLP---MGSPMG--GAMGQPPYYGQGPQQQFNGQPLGWPRMSMMPTPMGPGGPLRPNGlapMNAVRAPSRNAQ 451
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 688555903 956 PAPSPVQHQQHQAAAAAAAQAIHLGNPQQQQMYS----------ALAATPPSM 998
Cdd:TIGR01628 452 NAAQKPPMQPVMYPPNYQSLPLSQDLPQPQSTASqggqnkklaqVLASATPQM 504
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| SM-ATX |
pfam14438 |
Ataxin 2 SM domain; This SM domain is found in Ataxin-2. |
63-136 |
7.09e-20 |
|
Ataxin 2 SM domain; This SM domain is found in Ataxin-2.
Pssm-ID: 464173 Cd Length: 78 Bit Score: 84.91 E-value: 7.09e-20
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 688555903 63 MVHVLTSVVGTKCELKVKNGLIYEGVFKTYGPE--CDIVLDAAHRKSVEPNAG--PRREDIVESIIFKSSDVVVVHFK 136
Cdd:pfam14438 1 LLFLLTSLVGLVVEVTTKNGEVYEGIFSTASLEkdFGVVLKMARRIKKSNGSGlnPVRGEIVDTMIFPAKDIVDIEAK 78
|
|
| LsmAD |
pfam06741 |
LsmAD domain; This domain is found associated with Lsm domain. |
209-270 |
8.56e-17 |
|
LsmAD domain; This domain is found associated with Lsm domain.
Pssm-ID: 461998 [Multi-domain] Cd Length: 65 Bit Score: 75.69 E-value: 8.56e-17
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 688555903 209 YGVKSTYDSSLssYTVPLERdNSEEFLKREARASQLAEEIEASATYKARVALENDDR------SEEEK 270
Cdd:pfam06741 1 FGVKSTYDENL--YTTKLDR-SSPDYKEREAEAERIAREIEGSASTNAHVAEERGLDvddsglDEEDK 65
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
655-1079 |
3.30e-07 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 54.94 E-value: 3.30e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688555903 655 SAGSKAGTPSLSPSSAVPEQKRGPDVTSQGVQTTSPLANAVTKdKDEKEDKNDPVAESVRKSTLNPNAKEFNPRVFCSPP 734
Cdd:PHA03247 2581 AVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHA-PDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPG 2659
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688555903 735 KPATTPTLTRPQGQPSPSIVVQQP------PTVYGQTMFQMYPLTPVSPGVQPPAMYH-VQVPHMTMSQTKSYRSGKVQN 807
Cdd:PHA03247 2660 RVSRPRRARRLGRAAQASSPPQRPrrraarPTVGSLTSLADPPPPPPTPEPAPHALVSaTPLPPGPAAARQASPALPAAP 2739
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688555903 808 MPQQRPDQHHPPGTSTMMHS-ATAAGPPIVAPSPAYSTqyftcSPQQFASQPLVqqmphyqsqaqhvfSPVIQGSARMIT 886
Cdd:PHA03247 2740 APPAVPAGPATPGGPARPARpPTTAGPPAPAPPAAPAA-----GPPRRLTRPAV--------------ASLSESRESLPS 2800
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688555903 887 PPTHAQPSLVSSSTTQygeqthTMYVSQTPIPQQFPHPSSTLHPHPQHPQPSATPTgQPQQGTQHGGSHPAPSPVQHQQH 966
Cdd:PHA03247 2801 PWDPADPPAAVLAPAA------ALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSL-PLGGSVAPGGDVRRRPPSRSPAA 2873
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688555903 967 QAAAAAAAQAIHLGNPQQQQMYSALAATPPSMTPGPNPQSPQASFPSAQQAvyihpqhgynpnhmahvQQAHMQSGMVPP 1046
Cdd:PHA03247 2874 KPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPP-----------------PPPQPQPPPPPP 2936
|
410 420 430
....*....|....*....|....*....|...
gi 688555903 1047 HHGNPSHPPTMMLMATQAPAGPQPALPQGTLNP 1079
Cdd:PHA03247 2937 PRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVP 2969
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
830-1075 |
9.99e-07 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 53.23 E-value: 9.99e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688555903 830 AAGPPIVAPSPAYSTQYFTCSPQQFASQPLVQQMPH-YQSQAQHVFSPVIQGSARMITPPTHAQPSLVSSSTTQYGEQTH 908
Cdd:pfam03154 143 STSPSIPSPQDNESDSDSSAQQQILQTQPPVLQAQSgAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQ 222
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688555903 909 TMYVSQTPI-------PQQFPHPSSTLHPHPQHPQPSATPTGQPQQGTQHGGSHPAPSPVQHQQHQAAAAAAAQAIHLGN 981
Cdd:pfam03154 223 STAAPHTLIqqtptlhPQRLPSPHPPLQPMTQPPPPSQVSPQPLPQPSLHGQMPPMPHSLQTGPSHMQHPVPPQPFPLTP 302
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688555903 982 PQQQQM------------YSALAATPPSMTPGPNPQSP--QASFPSAQQAVYIHP------------QHGYNPNHMAHVQ 1035
Cdd:pfam03154 303 QSSQSQvppgpspaapgqSQQRIHTPPSQSQLQSQQPPreQPLPPAPLSMPHIKPppttpipqlpnpQSHKHPPHLSGPS 382
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 688555903 1036 QAHMQSGMVPP-----------HHGNPSHPPTMMLMATQAPAGPQPALPQG 1075
Cdd:pfam03154 383 PFQMNSNLPPPpalkplsslstHHPPSAHPPPLQLMPQSQQLPPPPAQPPV 433
|
|
| PAT1 |
pfam09770 |
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ... |
828-961 |
3.74e-06 |
|
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.
Pssm-ID: 401645 [Multi-domain] Cd Length: 846 Bit Score: 51.19 E-value: 3.74e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688555903 828 ATAAGPPIVAPSPAYSTQYFTCSPQQFASQPLVQQMPhyqsQAQHVFSPVIQGSARMITPPTHAQPSLVSSSTTQYGEQT 907
Cdd:pfam09770 210 PAQQPAPAPAQPPAAPPAQQAQQQQQFPPQIQQQQQP----QQQPQQPQQHPGQGHPVTILQRPQSPQPDPAQPSIQPQA 285
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 688555903 908 HTMYVSQTPIPQQFPH-------PSSTLHPHPQHPQPSATPtGQPQQGTQHGGSHPAPSPV 961
Cdd:pfam09770 286 QQFHQQPPPVPVQPTQilqnpnrLSAARVGYPQNPQPGVQP-APAHQAHRQQGSFGRQAPI 345
|
|
| PAT1 |
pfam09770 |
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ... |
842-1060 |
4.67e-06 |
|
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.
Pssm-ID: 401645 [Multi-domain] Cd Length: 846 Bit Score: 50.80 E-value: 4.67e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688555903 842 YSTQYFTCSPQQFASQPLVQQMPHYQ---SQAQHVFSPV---------------IQ--------GSARMITPPTHAQPSL 895
Cdd:pfam09770 102 FNRQQPAARAAQSSAQPPASSLPQYQyasQQSQQPSKPVrtgyekykepepipdLQvdaslwgvAPKKAAAPAPAPQPAA 181
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688555903 896 VSSSTTQYGE--------------QTHTMYVSQTPIPQQFPHPSSTLH-----PHPQHPQPSATPTGQPQQGTQHGGSHP 956
Cdd:pfam09770 182 QPASLPAPSRkmmsleeveaamraQAKKPAQQPAPAPAQPPAAPPAQQaqqqqQFPPQIQQQQQPQQQPQQPQQHPGQGH 261
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688555903 957 APSPVQHQQHQAAAAAAAQAIHLGNPQQQQmysalaatPPSMTPGPNPQSPQASFPSAQQAVYihPQHGYNPNHMAHVQQ 1036
Cdd:pfam09770 262 PVTILQRPQSPQPDPAQPSIQPQAQQFHQQ--------PPPVPVQPTQILQNPNRLSAARVGY--PQNPQPGVQPAPAHQ 331
|
250 260
....*....|....*....|....
gi 688555903 1037 AHMQSGMVPPHHGNPSHPPTMMLM 1060
Cdd:pfam09770 332 AHRQQGSFGRQAPIITHPQQLAQL 355
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
531-1026 |
2.55e-05 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 48.78 E-value: 2.55e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688555903 531 PIEEAKESRvlETRQNSPNANKENVKPIeASPGIARSIGKGSPSMASDHRKQidnlkkfSAAFRLQPSSSSDPGFEAMGT 610
Cdd:PHA03247 2577 PSEPAVTSR--ARRPDAPPQSARPRAPV-DDRGDPRGPAPPSPLPPDTHAPD-------PPPPSPSPAANEPDPHPPPTV 2646
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688555903 611 KPPrdlgEKPKDQAAekGSVDSTGLKASTESSISEETSSPVSVTSAGSKAGTPSLSPSSAVPEQKRGPDVTSQGVQTTSP 690
Cdd:PHA03247 2647 PPP----ERPRDDPA--PGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATP 2720
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688555903 691 LANAVTKDKDEKEDKN-DPVAESVRKSTLNPNAkefnPRVFCSPPKPATTPTLTRPQGQPSPSivvqqPPTVYGQTMFQM 769
Cdd:PHA03247 2721 LPPGPAAARQASPALPaAPAPPAVPAGPATPGG----PARPARPPTTAGPPAPAPPAAPAAGP-----PRRLTRPAVASL 2791
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688555903 770 YPLTPVSPGVQPPAMYHVQVPHMTMSQTksyrsgkvqnmPQQRPDQHHPPGTStmmhSATAAGPPIVAPSPAYSTQYFTC 849
Cdd:PHA03247 2792 SESRESLPSPWDPADPPAAVLAPAAALP-----------PAASPAGPLPPPTS----AQPTAPPPPPGPPPPSLPLGGSV 2856
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688555903 850 SPqqfasqplvqqmphyqsqaqhvfspviqGSARMITPPTHAQPSLVSSSTTQYGEQTHTMYVSQTPIPQQFPHPSSTLH 929
Cdd:PHA03247 2857 AP----------------------------GGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERP 2908
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688555903 930 PHPQHPQPsATPTGQPQQGTQhggshPAPSPVQHQQHQAAAAAAAQAIHLGNPQQQQMYSALAATPPSMTPGPNPQSPQA 1009
Cdd:PHA03247 2909 PQPQAPPP-PQPQPQPPPPPQ-----PQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQP 2982
|
490
....*....|....*..
gi 688555903 1010 SFPSAQQAVYIHPQHGY 1026
Cdd:PHA03247 2983 APSREAPASSTPPLTGH 2999
|
|
| PAT1 |
pfam09770 |
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ... |
711-958 |
2.76e-05 |
|
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.
Pssm-ID: 401645 [Multi-domain] Cd Length: 846 Bit Score: 48.49 E-value: 2.76e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688555903 711 ESVRKSTLNPNAKefnprvfcSPPKPATTPTLTRPQGQPSPSIVVQQPPTV------YGQT-----MFQMYPLTPVSPGV 779
Cdd:pfam09770 98 EQVRFNRQQPAAR--------AAQSSAQPPASSLPQYQYASQQSQQPSKPVrtgyekYKEPepipdLQVDASLWGVAPKK 169
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688555903 780 QPPAMYHVQVPHMTMSQTKSYR------------SGKVQNMPQQRPDQH-HPPGTSTMMHSATAAGPPIVAPSPAYSTQY 846
Cdd:pfam09770 170 AAAPAPAPQPAAQPASLPAPSRkmmsleeveaamRAQAKKPAQQPAPAPaQPPAAPPAQQAQQQQQFPPQIQQQQQPQQQ 249
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688555903 847 FTCSPQQFASQPLVQQMPHYQSQAqhvfSPVIQGSARMITPPTHAQPSLVSSSTTQYGEQTHTMYVSQTPIPQQFPHPSS 926
Cdd:pfam09770 250 PQQPQQHPGQGHPVTILQRPQSPQ----PDPAQPSIQPQAQQFHQQPPPVPVQPTQILQNPNRLSAARVGYPQNPQPGVQ 325
|
250 260 270
....*....|....*....|....*....|..
gi 688555903 927 TLHPHPQHPQPSATPTGQPQQgtqhggSHPAP 958
Cdd:pfam09770 326 PAPAHQAHRQQGSFGRQAPII------THPQQ 351
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
737-1083 |
2.37e-04 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 45.53 E-value: 2.37e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688555903 737 ATTPTLTRPQGQPSPS-------IVVQQPPTVYGQTMfqmyPLTPVSPGVQPPAMYHVQVPHMTMSQTKSYRSGKVQNMP 809
Cdd:pfam03154 143 STSPSIPSPQDNESDSdssaqqqILQTQPPVLQAQSG----AASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPP 218
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688555903 810 QQrpdQHHPPGTSTMMHSATAAGPP-IVAPSPAYSTQYFTCSPQQFASQPLVQqmPHYQSQAQHVFSPVIQGSARMITP- 887
Cdd:pfam03154 219 NQ---TQSTAAPHTLIQQTPTLHPQrLPSPHPPLQPMTQPPPPSQVSPQPLPQ--PSLHGQMPPMPHSLQTGPSHMQHPv 293
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688555903 888 PTHAQPSLVSSSTTQygeqthtmyVSQTPIPQQFPHPSSTLHPHPQHPQPSAT--PTGQPQQGTQHGGSHPAPSPVQHQQ 965
Cdd:pfam03154 294 PPQPFPLTPQSSQSQ---------VPPGPSPAAPGQSQQRIHTPPSQSQLQSQqpPREQPLPPAPLSMPHIKPPPTTPIP 364
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688555903 966 HQAAAAAAAQAIHLGNPQQQQMYSALAAtPPSMTPG---PNPQSPQASFPSAQqavyIHPQHGYNPNHMAHvQQAHMQSG 1042
Cdd:pfam03154 365 QLPNPQSHKHPPHLSGPSPFQMNSNLPP-PPALKPLsslSTHHPPSAHPPPLQ----LMPQSQQLPPPPAQ-PPVLTQSQ 438
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 688555903 1043 MVPPHHGNPSHPPTMMLMATQAPAGPQPALPQGTLNPIPVS 1083
Cdd:pfam03154 439 SLPPPAASHPPTSGLHQVPSQSPFPQHPFVPGGPPPITPPS 479
|
|
| PABP-1234 |
TIGR01628 |
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ... |
879-998 |
1.33e-03 |
|
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.
Pssm-ID: 130689 [Multi-domain] Cd Length: 562 Bit Score: 42.87 E-value: 1.33e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688555903 879 QGSARMITPPthaQPSLVSssTTQYGEQTHTMYVSQTPIPQQFPHPSSTLHPHPQHPQPSATPTG---QPQQGTQHGGSH 955
Cdd:TIGR01628 377 QLQPRMRQLP---MGSPMG--GAMGQPPYYGQGPQQQFNGQPLGWPRMSMMPTPMGPGGPLRPNGlapMNAVRAPSRNAQ 451
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 688555903 956 PAPSPVQHQQHQAAAAAAAQAIHLGNPQQQQMYS----------ALAATPPSM 998
Cdd:TIGR01628 452 NAAQKPPMQPVMYPPNYQSLPLSQDLPQPQSTASqggqnkklaqVLASATPQM 504
|
|
| PHA03378 |
PHA03378 |
EBNA-3B; Provisional |
776-1100 |
2.50e-03 |
|
EBNA-3B; Provisional
Pssm-ID: 223065 [Multi-domain] Cd Length: 991 Bit Score: 41.98 E-value: 2.50e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688555903 776 SPGVQPPAMYHVQVPhmTMSQTKSYRSGKVQN-MPQQRPDQHHPPGTSTMMHSATAAgpPIVAPSPAYSTQYFTCSPQQF 854
Cdd:PHA03378 566 APGLGPLQIQPLTSP--TTSQLASSAPSYAQTpWPVPHPSQTPEPPTTQSHIPETSA--PRQWPMPLRPIPMRPLRMQPI 641
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688555903 855 ASQPLVQQMPHYQSQAQhvfsPVIQGSARMITPPTHAQPSLVSSSTTQYGEQTHTmyVSQTPIPQQFPHPSSTLHPHPQH 934
Cdd:PHA03378 642 TFNVLVFPTPHQPPQVE----ITPYKPTWTQIGHIPYQPSPTGANTMLPIQWAPG--TMQPPPRAPTPMRPPAAPPGRAQ 715
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688555903 935 PQPSATPTGQPQQGTQHGGSHPAPSPVQHQQHQAAAAAAAQAIHLGNPqqqqmysalaATPPSMTPG-PNPQSPQASFPS 1013
Cdd:PHA03378 716 RPAAATGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPGR----------ARPPAAAPGaPTPQPPPQAPPA 785
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688555903 1014 AQQavyiHPQHGYNPNHMAHVQQAHMQ-SGMVPPHHGNPSHPPTMMLM-----------------ATQAPAGPQPAlPQG 1075
Cdd:PHA03378 786 PQQ----RPRGAPTPQPPPQAGPTSMQlMPRAAPGQQGPTKQILRQLLtggvkrgrpslkkpaalERQAAAGPTPS-PGS 860
|
330 340
....*....|....*....|....*
gi 688555903 1076 TLNPIPVSSGTHFYSTLTPVQAHHQ 1100
Cdd:PHA03378 861 GTSDKIVQAPVFYPPVLQPIQVMRQ 885
|
|
| Med15 |
pfam09606 |
ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of ... |
747-1078 |
2.89e-03 |
|
ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of the ARC-Mediator co-activator is a three-helix bundle with marked similarity to the KIX domain. The sterol regulatory element binding protein (SREBP) family of transcription activators use the ARC105 subunit to activate target genes in the regulation of cholesterol and fatty acid homeostasis. In addition, Med15 is a critical transducer of gene activation signals that control early metazoan development.
Pssm-ID: 312941 [Multi-domain] Cd Length: 732 Bit Score: 41.92 E-value: 2.89e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688555903 747 GQPSPSIVVQQPPTVYGQTMFQMYPLTPVSPGVQPPAmyhvQVPHMTMSQTKSYRSGKVQNMPQQRPDQHHPPGTSTMMH 826
Cdd:pfam09606 156 GGMMQPSSGQPGSGTPNQMGPNGGPGQGQAGGMNGGQ----QGPMGGQMPPQMGVPGMPGPADAGAQMGQQAQANGGMNP 231
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688555903 827 SATAAGPPIVAPSPAYSTQYFTCSPQQFASQPLvQQMPHYQSQAQHvfspviQGSARMITPPTHAQPSLVSSsttQYGEQ 906
Cdd:pfam09606 232 QQMGGAPNQVAMQQQQPQQQGQQSQLGMGINQM-QQMPQGVGGGAG------QGGPGQPMGPPGQQPGAMPN---VMSIG 301
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688555903 907 THTMYVSQTPIPQQfphpsstlhphpqHPQPSATPTGQPQQGTQHGGSHPAPSPVQHQQHQAAAAAAAQAIHLGNPQQQQ 986
Cdd:pfam09606 302 DQNNYQQQQTRQQQ-------------QQQGGNHPAAHQQQMNQSVGQGGQVVALGGLNHLETWNPGNFGGLGANPMQRG 368
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688555903 987 mysalaatPPSMTPGPNP--------QSPQASFPSAQQAVYIHPQH-GYNPNhmahvqQAHMqSGMVPPHHGNPSHPPTM 1057
Cdd:pfam09606 369 --------QPGMMSSPSPvpgqqvrqVTPNQFMRQSPQPSVPSPQGpGSQPP------QSHP-GGMIPSPALIPSPSPQM 433
|
330 340
....*....|....*....|.
gi 688555903 1058 MLMaTQAPAGPQPALPQGTLN 1078
Cdd:pfam09606 434 SQQ-PAQQRTIGQDSPGGSLN 453
|
|
| PAM2 |
pfam07145 |
Ataxin-2 C-terminal region; The PABP-interacting motif PAM2 has been identified in various ... |
714-729 |
2.94e-03 |
|
Ataxin-2 C-terminal region; The PABP-interacting motif PAM2 has been identified in various eukaryotic proteins as an important binding site for pfam00658. It has been found in a wide range of eukaryotic proteins. Strikingly, this motif appears to occur solely outside of globular domains.
Pssm-ID: 429316 Cd Length: 17 Bit Score: 36.05 E-value: 2.94e-03
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
733-1027 |
6.15e-03 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 40.91 E-value: 6.15e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688555903 733 PPKPATTPTLtRPQGQPSPSIVVQQPPTVYGQTMFQMYPLTPVSPGVQPPAMYHVQVPHMTMSQTKSYRSGKVQNMPQQR 812
Cdd:pfam03154 262 SPQPLPQPSL-HGQMPPMPHSLQTGPSHMQHPVPPQPFPLTPQSSQSQVPPGPSPAAPGQSQQRIHTPPSQSQLQSQQPP 340
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688555903 813 PDQHHPPGTSTMMH---SATAAGPPIVAP-SPAYSTQYFTCSPQQFAS--------QPLVQQMPHYQSQAqHVFSPVIQG 880
Cdd:pfam03154 341 REQPLPPAPLSMPHikpPPTTPIPQLPNPqSHKHPPHLSGPSPFQMNSnlppppalKPLSSLSTHHPPSA-HPPPLQLMP 419
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688555903 881 SARMITPPTHAQPSLVSSSTTQYGEQTHTMYVSQTPIPQQFPHPSstlHPHPQHPQPSATPTGQPQQGTQHGGSHPAP-- 958
Cdd:pfam03154 420 QSQQLPPPPAQPPVLTQSQSLPPPAASHPPTSGLHQVPSQSPFPQ---HPFVPGGPPPITPPSGPPTSTSSAMPGIQPps 496
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 688555903 959 --SPVQHQQHQAAAAAAAQAIHLGNPQQQQMYSALAATPPSMTPGPNPQSPQASFPSAQQA-VYIHPQHGYN 1027
Cdd:pfam03154 497 saSVSSSGPVPAAVSCPLPPVQIKEEALDEAEEPESPPPPPRSPSPEPTVVNTPSHASQSArFYKHLDRGYN 568
|
|
| |
