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Conserved domains on  [gi|731236461|ref|XP_010631802|]
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nuclear-interacting partner of ALK isoform X1 [Fukomys damarensis]

Protein Classification

zf-C3HC and Rsm1 domain-containing protein( domain architecture ID 10546425)

zf-C3HC and Rsm1 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
zf-C3HC pfam07967
C3HC zinc finger-like; This zinc-finger like domain is distributed throughout the eukaryotic ...
 72-200 5.06e-54

C3HC zinc finger-like; This zinc-finger like domain is distributed throughout the eukaryotic kingdom in NIPA (Nuclear interacting partner of ALK) proteins. NIPA is implicate to perform some sort of antiapoptotic role in nucleophosmin-anaplastic lymphoma kinase (ALK) mediated signaling events. The domain is often repeated, with the second domain usually containing a large insert (approximately 90 residues) after the first three cysteine residues. The Schizosaccharomyces pombe the protein containing this domain is involved in mRNA export from the nucleus.


:

Pssm-ID: 429759  Cd Length: 132  Bit Score: 177.95  E-value: 5.06e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731236461   72 TSKEAFFSRVETFSSLKWAGKPPELSPLMCAKYGWVTVECDMLKCSSCQAFLCASL--QPAFDFDRYKERCDELKKSLCT 149
Cdd:pfam07967   2 WSREDFLRRLKTFKALTWTGKPSALSPLACAKRGWVCVDKDMLKCESCGAYLCVSKdnIVELDFQLYNKLIEEYAKQLVT 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 731236461  150 AHEKFCFWPDSPCPDRFGMLPLDEPAVLISDFLDRFQSLCHLDLQLPSLRP 200
Cdd:pfam07967  82 GHEENCPWRNNGCPESYERLPLAAPDTLLSDLKKRYDGLLQRFDQLPSLVN 132
Rsm1 super family cl07279
Rsm1-like; Rsm1 is a protein involved in mRNA export from the nucleus
 247-337 4.10e-07

Rsm1-like; Rsm1 is a protein involved in mRNA export from the nucleus


The actual alignment was detected with superfamily member pfam08600:

Pssm-ID: 369989  Cd Length: 97  Bit Score: 48.24  E-value: 4.10e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731236461  247 ACILSVCGWacsSSLEPMQLSLITCSQCMRKVGLWGFQQIESSMTDlDSSFGQTSSPITGPEGRPDRFPPVPESPRRIMT 326
Cdd:pfam08600   1 AFALALFGW---DSVPDGRLGLAGCGACFRRLGLWMFKPKEDGEAS-NKLVPAVVDRLDVLEEHREYCPWVNPKAQSGTG 76

                          90
                  ....*....|.
gi 731236461  327 RSQDASFSPCS 337
Cdd:pfam08600  77 RSSDALDGLAS 87
Rsm1 super family cl07279
Rsm1-like; Rsm1 is a protein involved in mRNA export from the nucleus
 418-465 2.06e-03

Rsm1-like; Rsm1 is a protein involved in mRNA export from the nucleus


The actual alignment was detected with superfamily member pfam08600:

Pssm-ID: 369989  Cd Length: 97  Bit Score: 37.46  E-value: 2.06e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 731236461  418 FDPTSQHRDWCPWVNSTlgreAEENRGTEQDASTPVEPGWKAVLTMLL 465
Cdd:pfam08600  54 LDVLEEHREYCPWVNPK----AQSGTGRSSDALDGLASGWELLAQALK 97
 
Name Accession Description Interval E-value
zf-C3HC pfam07967
C3HC zinc finger-like; This zinc-finger like domain is distributed throughout the eukaryotic ...
 72-200 5.06e-54

C3HC zinc finger-like; This zinc-finger like domain is distributed throughout the eukaryotic kingdom in NIPA (Nuclear interacting partner of ALK) proteins. NIPA is implicate to perform some sort of antiapoptotic role in nucleophosmin-anaplastic lymphoma kinase (ALK) mediated signaling events. The domain is often repeated, with the second domain usually containing a large insert (approximately 90 residues) after the first three cysteine residues. The Schizosaccharomyces pombe the protein containing this domain is involved in mRNA export from the nucleus.


Pssm-ID: 429759  Cd Length: 132  Bit Score: 177.95  E-value: 5.06e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731236461   72 TSKEAFFSRVETFSSLKWAGKPPELSPLMCAKYGWVTVECDMLKCSSCQAFLCASL--QPAFDFDRYKERCDELKKSLCT 149
Cdd:pfam07967   2 WSREDFLRRLKTFKALTWTGKPSALSPLACAKRGWVCVDKDMLKCESCGAYLCVSKdnIVELDFQLYNKLIEEYAKQLVT 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 731236461  150 AHEKFCFWPDSPCPDRFGMLPLDEPAVLISDFLDRFQSLCHLDLQLPSLRP 200
Cdd:pfam07967  82 GHEENCPWRNNGCPESYERLPLAAPDTLLSDLKKRYDGLLQRFDQLPSLVN 132
Rsm1 pfam08600
Rsm1-like; Rsm1 is a protein involved in mRNA export from the nucleus
 247-337 4.10e-07

Rsm1-like; Rsm1 is a protein involved in mRNA export from the nucleus


Pssm-ID: 369989  Cd Length: 97  Bit Score: 48.24  E-value: 4.10e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731236461  247 ACILSVCGWacsSSLEPMQLSLITCSQCMRKVGLWGFQQIESSMTDlDSSFGQTSSPITGPEGRPDRFPPVPESPRRIMT 326
Cdd:pfam08600   1 AFALALFGW---DSVPDGRLGLAGCGACFRRLGLWMFKPKEDGEAS-NKLVPAVVDRLDVLEEHREYCPWVNPKAQSGTG 76

                          90
                  ....*....|.
gi 731236461  327 RSQDASFSPCS 337
Cdd:pfam08600  77 RSSDALDGLAS 87
Rsm1 pfam08600
Rsm1-like; Rsm1 is a protein involved in mRNA export from the nucleus
 418-465 2.06e-03

Rsm1-like; Rsm1 is a protein involved in mRNA export from the nucleus


Pssm-ID: 369989  Cd Length: 97  Bit Score: 37.46  E-value: 2.06e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 731236461  418 FDPTSQHRDWCPWVNSTlgreAEENRGTEQDASTPVEPGWKAVLTMLL 465
Cdd:pfam08600  54 LDVLEEHREYCPWVNPK----AQSGTGRSSDALDGLASGWELLAQALK 97
 
Name Accession Description Interval E-value
zf-C3HC pfam07967
C3HC zinc finger-like; This zinc-finger like domain is distributed throughout the eukaryotic ...
 72-200 5.06e-54

C3HC zinc finger-like; This zinc-finger like domain is distributed throughout the eukaryotic kingdom in NIPA (Nuclear interacting partner of ALK) proteins. NIPA is implicate to perform some sort of antiapoptotic role in nucleophosmin-anaplastic lymphoma kinase (ALK) mediated signaling events. The domain is often repeated, with the second domain usually containing a large insert (approximately 90 residues) after the first three cysteine residues. The Schizosaccharomyces pombe the protein containing this domain is involved in mRNA export from the nucleus.


Pssm-ID: 429759  Cd Length: 132  Bit Score: 177.95  E-value: 5.06e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731236461   72 TSKEAFFSRVETFSSLKWAGKPPELSPLMCAKYGWVTVECDMLKCSSCQAFLCASL--QPAFDFDRYKERCDELKKSLCT 149
Cdd:pfam07967   2 WSREDFLRRLKTFKALTWTGKPSALSPLACAKRGWVCVDKDMLKCESCGAYLCVSKdnIVELDFQLYNKLIEEYAKQLVT 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 731236461  150 AHEKFCFWPDSPCPDRFGMLPLDEPAVLISDFLDRFQSLCHLDLQLPSLRP 200
Cdd:pfam07967  82 GHEENCPWRNNGCPESYERLPLAAPDTLLSDLKKRYDGLLQRFDQLPSLVN 132
Rsm1 pfam08600
Rsm1-like; Rsm1 is a protein involved in mRNA export from the nucleus
 247-337 4.10e-07

Rsm1-like; Rsm1 is a protein involved in mRNA export from the nucleus


Pssm-ID: 369989  Cd Length: 97  Bit Score: 48.24  E-value: 4.10e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731236461  247 ACILSVCGWacsSSLEPMQLSLITCSQCMRKVGLWGFQQIESSMTDlDSSFGQTSSPITGPEGRPDRFPPVPESPRRIMT 326
Cdd:pfam08600   1 AFALALFGW---DSVPDGRLGLAGCGACFRRLGLWMFKPKEDGEAS-NKLVPAVVDRLDVLEEHREYCPWVNPKAQSGTG 76

                          90
                  ....*....|.
gi 731236461  327 RSQDASFSPCS 337
Cdd:pfam08600  77 RSSDALDGLAS 87
Rsm1 pfam08600
Rsm1-like; Rsm1 is a protein involved in mRNA export from the nucleus
 418-465 2.06e-03

Rsm1-like; Rsm1 is a protein involved in mRNA export from the nucleus


Pssm-ID: 369989  Cd Length: 97  Bit Score: 37.46  E-value: 2.06e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 731236461  418 FDPTSQHRDWCPWVNSTlgreAEENRGTEQDASTPVEPGWKAVLTMLL 465
Cdd:pfam08600  54 LDVLEEHREYCPWVNPK----AQSGTGRSSDALDGLASGWELLAQALK 97
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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