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Conserved domains on  [gi|1387274989|ref|XP_010805504|]
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zinc finger protein 692 isoform X1 [Bos taurus]

Protein Classification

C2H2-type zinc finger family protein( domain architecture ID 705934)

Cys2His2 (C2H2)-type zinc finger family protein may be involved in transcriptional regulation

Gene Ontology:  GO:0046872

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SFP1 super family cl25788
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 258-373 9.38e-06

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


The actual alignment was detected with superfamily member COG5189:

Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 47.79  E-value: 9.38e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387274989 258 ASPGNQAQSALASAWDEDTAQIGPKRIRKAAKRELLPCDFPGCGRIFSNRQYLNHHKKYQHIHQKSFSCPEPACGKSFNF 337
Cdd:COG5189   315 KLPCTNSSSNGKLAHGGERNIDTPSRMLKVKDGKPYKCPVEGCNKKYKNQNGLKYHMLHGHQNQKLHENPSPEKMNIFSA 394

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1387274989 338 KKhlkehvklhsdtRDYICEFCARSFRTSSNLVIHR 373
Cdd:COG5189   395 KD------------KPYRCEVCDKRYKNLNGLKYHR 418
COG5236 super family cl28715
Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only];
323-438 2.73e-03

Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only];


The actual alignment was detected with superfamily member COG5236:

Pssm-ID: 227561 [Multi-domain]  Cd Length: 493  Bit Score: 40.00  E-value: 2.73e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387274989 323 SFSCPEPACGKSFNFKKHLKEHVKlhSDTRDYICEFCArsfrtssnlvihrrihTGEKPLQCEICGFTcrqKASLNWHRR 402
Cdd:COG5236   151 SFKCPKSKCHRRCGSLKELKKHYK--AQHGFVLCSECI----------------GNKKDFWNEIRLFR---SSTLRDHKN 209

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1387274989 403 KHAETVAALRFP-CEFCGKRFEKPDSVAAHRSKSHPA 438
Cdd:COG5236   210 GGLEEEGFKGHPlCIFCKIYFYDDDELRRHCRLRHEA 246
 
Name Accession Description Interval E-value
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 258-373 9.38e-06

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 47.79  E-value: 9.38e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387274989 258 ASPGNQAQSALASAWDEDTAQIGPKRIRKAAKRELLPCDFPGCGRIFSNRQYLNHHKKYQHIHQKSFSCPEPACGKSFNF 337
Cdd:COG5189   315 KLPCTNSSSNGKLAHGGERNIDTPSRMLKVKDGKPYKCPVEGCNKKYKNQNGLKYHMLHGHQNQKLHENPSPEKMNIFSA 394

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1387274989 338 KKhlkehvklhsdtRDYICEFCARSFRTSSNLVIHR 373
Cdd:COG5189   395 KD------------KPYRCEVCDKRYKNLNGLKYHR 418
zf-C2H2_8 pfam15909
C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.
 294-375 9.75e-04

C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.


Pssm-ID: 464935 [Multi-domain]  Cd Length: 98  Bit Score: 38.55  E-value: 9.75e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387274989 294 PCDFPGCGRIFSNRQYLNHHKKY-----QHIHQKSFSCPEPACGKSFNFKKHLKEHVKLHSDTRDYI-CEFCARSFRTSS 367
Cdd:pfam15909   1 PCSSPGCCLSFPSVRDLAQHLRThcpptQSLEGKLFRCSALSCTETFPSMQELVAHSKLHYKPNRYFkCENCLLRFRTHR 80


                  ....*...
gi 1387274989 368 NLVIHRRI 375
Cdd:pfam15909  81 SLFKHLHV 88
COG5236 COG5236
Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only];
323-438 2.73e-03

Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only];


Pssm-ID: 227561 [Multi-domain]  Cd Length: 493  Bit Score: 40.00  E-value: 2.73e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387274989 323 SFSCPEPACGKSFNFKKHLKEHVKlhSDTRDYICEFCArsfrtssnlvihrrihTGEKPLQCEICGFTcrqKASLNWHRR 402
Cdd:COG5236   151 SFKCPKSKCHRRCGSLKELKKHYK--AQHGFVLCSECI----------------GNKKDFWNEIRLFR---SSTLRDHKN 209

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1387274989 403 KHAETVAALRFP-CEFCGKRFEKPDSVAAHRSKSHPA 438
Cdd:COG5236   210 GGLEEEGFKGHPlCIFCKIYFYDDDELRRHCRLRHEA 246
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 383-404 7.30e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 33.81  E-value: 7.30e-03
                          10        20
                  ....*....|....*....|..
gi 1387274989 383 QCEICGFTCRQKASLNWHRRKH 404
Cdd:pfam00096   2 KCPDCGKSFSRKSNLKRHLRTH 23
 
Name Accession Description Interval E-value
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 258-373 9.38e-06

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 47.79  E-value: 9.38e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387274989 258 ASPGNQAQSALASAWDEDTAQIGPKRIRKAAKRELLPCDFPGCGRIFSNRQYLNHHKKYQHIHQKSFSCPEPACGKSFNF 337
Cdd:COG5189   315 KLPCTNSSSNGKLAHGGERNIDTPSRMLKVKDGKPYKCPVEGCNKKYKNQNGLKYHMLHGHQNQKLHENPSPEKMNIFSA 394

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1387274989 338 KKhlkehvklhsdtRDYICEFCARSFRTSSNLVIHR 373
Cdd:COG5189   395 KD------------KPYRCEVCDKRYKNLNGLKYHR 418
zf-C2H2_8 pfam15909
C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.
 294-375 9.75e-04

C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.


Pssm-ID: 464935 [Multi-domain]  Cd Length: 98  Bit Score: 38.55  E-value: 9.75e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387274989 294 PCDFPGCGRIFSNRQYLNHHKKY-----QHIHQKSFSCPEPACGKSFNFKKHLKEHVKLHSDTRDYI-CEFCARSFRTSS 367
Cdd:pfam15909   1 PCSSPGCCLSFPSVRDLAQHLRThcpptQSLEGKLFRCSALSCTETFPSMQELVAHSKLHYKPNRYFkCENCLLRFRTHR 80


                  ....*...
gi 1387274989 368 NLVIHRRI 375
Cdd:pfam15909  81 SLFKHLHV 88
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 354-376 2.25e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.35  E-value: 2.25e-03
                          10        20
                  ....*....|....*....|...
gi 1387274989 354 YICEFCARSFRTSSNLVIHRRIH 376
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
COG5236 COG5236
Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only];
323-438 2.73e-03

Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only];


Pssm-ID: 227561 [Multi-domain]  Cd Length: 493  Bit Score: 40.00  E-value: 2.73e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387274989 323 SFSCPEPACGKSFNFKKHLKEHVKlhSDTRDYICEFCArsfrtssnlvihrrihTGEKPLQCEICGFTcrqKASLNWHRR 402
Cdd:COG5236   151 SFKCPKSKCHRRCGSLKELKKHYK--AQHGFVLCSECI----------------GNKKDFWNEIRLFR---SSTLRDHKN 209

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1387274989 403 KHAETVAALRFP-CEFCGKRFEKPDSVAAHRSKSHPA 438
Cdd:COG5236   210 GGLEEEGFKGHPlCIFCKIYFYDDDELRRHCRLRHEA 246
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
349-402 4.49e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 39.29  E-value: 4.49e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1387274989 349 SDTRDYICEFCARSFRTSSNLVIHRRIHTGEKPLQCEICGFTCRQKASLNWHRR 402
Cdd:COG5048    29 NAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRH 82
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 383-404 7.30e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 33.81  E-value: 7.30e-03
                          10        20
                  ....*....|....*....|..
gi 1387274989 383 QCEICGFTCRQKASLNWHRRKH 404
Cdd:pfam00096   2 KCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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