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Conserved domains on  [gi|741952451|ref|XP_010811026|]
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tsukushi isoform X1 [Bos taurus]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
68-303 2.52e-16

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 79.59  E-value: 2.52e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741952451  68 LDLSSNRLETVNESVlagPGYTTLSGLDLSYNLLTSLsPTAFSRLRYLESLDLSHNGLAALPTGSFTSSPLSDVNLSHNR 147
Cdd:COG4886  118 LDLSGNQLTDLPEEL---ANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQ 193

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741952451 148 LREVSvSAFATHSQGRALhvDLSHNLLQRLlphsSRAGQPAPTIQSLNLAWNRLRAVPDLRGLP-LRYLSLDGNPLAAIG 226
Cdd:COG4886  194 ITDLP-EPLGNLTNLEEL--DLSGNQLTDL----PEPLANLTNLETLDLSNNQLTDLPELGNLTnLEELDLSNNQLTDLP 266

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 741952451 227 PGAfeGLAGLTHLSLGSLQglpmLAPHSFHELQGLQVLDLSSNPRLQWAGPEVFSGLGSLQELDLSGTGLVPLPEKL 303
Cdd:COG4886  267 PLA--NLTNLKTLDLSNNQ----LTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTL 337
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
68-303 2.52e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 79.59  E-value: 2.52e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741952451  68 LDLSSNRLETVNESVlagPGYTTLSGLDLSYNLLTSLsPTAFSRLRYLESLDLSHNGLAALPTGSFTSSPLSDVNLSHNR 147
Cdd:COG4886  118 LDLSGNQLTDLPEEL---ANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQ 193

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741952451 148 LREVSvSAFATHSQGRALhvDLSHNLLQRLlphsSRAGQPAPTIQSLNLAWNRLRAVPDLRGLP-LRYLSLDGNPLAAIG 226
Cdd:COG4886  194 ITDLP-EPLGNLTNLEEL--DLSGNQLTDL----PEPLANLTNLETLDLSNNQLTDLPELGNLTnLEELDLSNNQLTDLP 266

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 741952451 227 PGAfeGLAGLTHLSLGSLQglpmLAPHSFHELQGLQVLDLSSNPRLQWAGPEVFSGLGSLQELDLSGTGLVPLPEKL 303
Cdd:COG4886  267 PLA--NLTNLKTLDLSNNQ----LTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTL 337
LRR_8 pfam13855
Leucine rich repeat;
68-125 3.11e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 52.53  E-value: 3.11e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 741952451   68 LDLSSNRLETVNESVLAGPgyTTLSGLDLSYNLLTSLSPTAFSRLRYLESLDLSHNGL 125
Cdd:pfam13855   6 LDLSNNRLTSLDDGAFKGL--SNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 68-179 5.84e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 54.47  E-value: 5.84e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741952451  68 LDLSSNRLETVNESVLAGpgYTTLSGLDLSYNLLTSLSPTAFSRLRYLESLDLSHNGLAALPTGSFTSSP-LSDVNLSHN 146
Cdd:PLN00113 480 LDLSRNQFSGAVPRKLGS--LSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPvLSQLDLSQN 557

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 741952451 147 RLrevsvSAFATHSQGRA---LHVDLSHNLLQRLLP 179
Cdd:PLN00113 558 QL-----SGEIPKNLGNVeslVQVNISHNHLHGSLP 588
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 43-296 3.82e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 41.96  E-value: 3.82e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741952451  43 SLTRVGCSGLGPHIVPVPiplDTAHLDLSSNRLETVNESV-LAGPGYTTLSGL---DLSYNLLTSLSPTAFSRLR---YL 115
Cdd:cd00116   34 TLGEEAAKALASALRPQP---SLKELCLSLNETGRIPRGLqSLLQGLTKGCGLqelDLSDNALGPDGCGVLESLLrssSL 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741952451 116 ESLDLSHNGLAALPT----GSFTSSP--LSDVNLSHNRLrevsvsafaTHSQGRALHVDLSHNllqrllphssragqpaP 189
Cdd:cd00116  111 QELKLNNNGLGDRGLrllaKGLKDLPpaLEKLVLGRNRL---------EGASCEALAKALRAN----------------R 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741952451 190 TIQSLNLAWNRLR--AVPDL-RGLP----LRYLSLDGNPLAAIGPGAFEGLaglthlslgslqglpmlaphsFHELQGLQ 262
Cdd:cd00116  166 DLKELNLANNGIGdaGIRALaEGLKancnLEVLDLNNNGLTDEGASALAET---------------------LASLKSLE 224

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 741952451 263 VLDLSSNPRLQWAGPEVFSGLG----SLQELDLSGTGL 296
Cdd:cd00116  225 VLNLGDNNLTDAGAAALASALLspniSLLTLSLSCNDI 262
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
68-303 2.52e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 79.59  E-value: 2.52e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741952451  68 LDLSSNRLETVNESVlagPGYTTLSGLDLSYNLLTSLsPTAFSRLRYLESLDLSHNGLAALPTGSFTSSPLSDVNLSHNR 147
Cdd:COG4886  118 LDLSGNQLTDLPEEL---ANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQ 193

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741952451 148 LREVSvSAFATHSQGRALhvDLSHNLLQRLlphsSRAGQPAPTIQSLNLAWNRLRAVPDLRGLP-LRYLSLDGNPLAAIG 226
Cdd:COG4886  194 ITDLP-EPLGNLTNLEEL--DLSGNQLTDL----PEPLANLTNLETLDLSNNQLTDLPELGNLTnLEELDLSNNQLTDLP 266

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 741952451 227 PGAfeGLAGLTHLSLGSLQglpmLAPHSFHELQGLQVLDLSSNPRLQWAGPEVFSGLGSLQELDLSGTGLVPLPEKL 303
Cdd:COG4886  267 PLA--NLTNLKTLDLSNNQ----LTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTL 337
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
89-312 8.65e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 78.05  E-value: 8.65e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741952451  89 TTLSGLDLSYNlltslspTAFSRLRYLESLDLSHNGLAALPT--GSFTSspLSDVNLSHNRLREVSvSAFATHSQGRALh 166
Cdd:COG4886   96 TNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDLPEelANLTN--LKELDLSNNQLTDLP-EPLGNLTNLKSL- 164

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741952451 167 vDLSHNLLQRLlphsSRAGQPAPTIQSLNLAWNRLRAVPD-LRGLP-LRYLSLDGNPLAAIgPGAFEGLAGLTHLSLGS- 243
Cdd:COG4886  165 -DLSNNQLTDL----PEELGNLTNLKELDLSNNQITDLPEpLGNLTnLEELDLSGNQLTDL-PEPLANLTNLETLDLSNn 238

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741952451 244 -LQGLPMLAphsfhELQGLQVLDLSSNpRLQWAGPEvfSGLGSLQELDLSGTGLVPLPEKLLVHLPALQS 312
Cdd:COG4886  239 qLTDLPELG-----NLTNLEELDLSNN-QLTDLPPL--ANLTNLKTLDLSNNQLTDLKLKELELLLGLNS 300
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
63-315 9.77e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 74.97  E-value: 9.77e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741952451  63 LDTAHLDLSSNRLETVNESVLAGPGYTTLSGLDLSYNLLTSLSPTAFSRLRYLESLDLSHNglaaLPTGSFTSspLSDVN 142
Cdd:COG4886   46 LLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN----EELSNLTN--LESLD 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741952451 143 LSHNRLREVSVSAfathSQGRAL-HVDLSHNLLQRLLPhssrAGQPAPTIQSLNLAWNRLRAVPD-LRGLP-LRYLSLDG 219
Cdd:COG4886  120 LSGNQLTDLPEEL----ANLTNLkELDLSNNQLTDLPE----PLGNLTNLKSLDLSNNQLTDLPEeLGNLTnLKELDLSN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741952451 220 NPLAAIgPGAFEGLAGLTHLSLGS--LQGLpmlaPHSFHELQGLQVLDLSSNP--RLQWagpevFSGLGSLQELDLSGTG 295
Cdd:COG4886  192 NQITDL-PEPLGNLTNLEELDLSGnqLTDL----PEPLANLTNLETLDLSNNQltDLPE-----LGNLTNLEELDLSNNQ 261

                        250       260
                 ....*....|....*....|
gi 741952451 296 LVPLPEklLVHLPALQSISV 315
Cdd:COG4886  262 LTDLPP--LANLTNLKTLDL 279
LRR_8 pfam13855
Leucine rich repeat;
68-125 3.11e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 52.53  E-value: 3.11e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 741952451   68 LDLSSNRLETVNESVLAGPgyTTLSGLDLSYNLLTSLSPTAFSRLRYLESLDLSHNGL 125
Cdd:pfam13855   6 LDLSNNRLTSLDDGAFKGL--SNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
94-148 2.62e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.83  E-value: 2.62e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 741952451   94 LDLSYNLLTSLSPTAFSRLRYLESLDLSHNGLAALPTGSFTSSP-LSDVNLSHNRL 148
Cdd:pfam13855   6 LDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPsLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
212-270 3.87e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.45  E-value: 3.87e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 741952451  212 LRYLSLDGNPLAAIGPGAFEGLAGLTHLSLG--SLQGLPmlaPHSFHELQGLQVLDLSSNP 270
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSnnLLTTLS---PGAFSGLPSLRYLDLSGNR 60
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 68-179 5.84e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 54.47  E-value: 5.84e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741952451  68 LDLSSNRLETVNESVLAGpgYTTLSGLDLSYNLLTSLSPTAFSRLRYLESLDLSHNGLAALPTGSFTSSP-LSDVNLSHN 146
Cdd:PLN00113 480 LDLSRNQFSGAVPRKLGS--LSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPvLSQLDLSQN 557

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 741952451 147 RLrevsvSAFATHSQGRA---LHVDLSHNLLQRLLP 179
Cdd:PLN00113 558 QL-----SGEIPKNLGNVeslVQVNISHNHLHGSLP 588
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
117-327 1.06e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 50.47  E-value: 1.06e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741952451 117 SLDLSHNGLAALPTgsftssplsdvNLsHNRLREVSVSAFATHSQGRAL-----HVDLSHNLLQRLLPHSSRAgqpaptI 191
Cdd:PRK15370 203 TLILDNNELKSLPE-----------NL-QGNIKTLYANSNQLTSIPATLpdtiqEMELSINRITELPERLPSA------L 264

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741952451 192 QSLNLAWNRLRAVPDlrGLP--LRYLSLDGNPLAAIgPGAFEglAGLTHLSL--GSLQGLPMLAPHSFHELQG------- 260
Cdd:PRK15370 265 QSLDLFHNKISCLPE--NLPeeLRYLSVYDNSIRTL-PAHLP--SGITHLNVqsNSLTALPETLPPGLKTLEAgenalts 339

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741952451 261 --------LQVLDLSSNpRLQwAGPEVFSglGSLQELDLSGTGLVPLPEKL-------------LVHLPALQSISVGQGV 319
Cdd:PRK15370 340 lpaslppeLQVLDVSKN-QIT-VLPETLP--PTITTLDVSRNALTNLPENLpaalqimqasrnnLVRLPESLPHFRGEGP 415


                 ....*...
gi 741952451 320 QCRRLVRE 327
Cdd:PRK15370 416 QPTRIIVE 423
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 68-292 6.75e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 47.92  E-value: 6.75e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741952451  68 LDLSSNRLETVNESVLAGPGYttLSGLDLSYNLLTSLSPTAFSRLRYLESLDLSHNGLAALPTGSFTSSPLSD-VNLSHN 146
Cdd:PLN00113 361 LDLSTNNLTGEIPEGLCSSGN--LFKLILFSNSLEGEIPKSLGACRSLRRVRLQDNSFSGELPSEFTKLPLVYfLDISNN 438

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741952451 147 RLREVSVSAFATHSQGRALhvDLSHNLLQRLLPHSSRAGQpaptIQSLNLAWNRLR-AVPD-LRGLP-LRYLSLDGNPLA 223
Cdd:PLN00113 439 NLQGRINSRKWDMPSLQML--SLARNKFFGGLPDSFGSKR----LENLDLSRNQFSgAVPRkLGSLSeLMQLKLSENKLS 512

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 741952451 224 AIGPGAFEGLAGLTHLSLgSLQGLPMLAPHSFHELQGLQVLDLSSNpRLQWAGPEVFSGLGSLQELDLS 292
Cdd:PLN00113 513 GEIPDELSSCKKLVSLDL-SHNQLSGQIPASFSEMPVLSQLDLSQN-QLSGEIPKNLGNVESLVQVNIS 579
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 91-303 4.87e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 45.22  E-value: 4.87e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741952451  91 LSGLDLS-YNLLTSLSPTAFsRLRYLESLDLSHNGLAA-LPTGSFTSSplsdvnlshNRLRevsvsafathsqgralHVD 168
Cdd:PLN00113  71 VVSIDLSgKNISGKISSAIF-RLPYIQTINLSNNQLSGpIPDDIFTTS---------SSLR----------------YLN 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741952451 169 LSHNLLQRLLPHSSragqpAPTIQSLNLAWNRLRA-VPDLRGL--PLRYLSLDGNPLAAIGPGAFEGLAGLTHLSLGSLQ 245
Cdd:PLN00113 125 LSNNNFTGSIPRGS-----IPNLETLDLSNNMLSGeIPNDIGSfsSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQ 199

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 741952451 246 gLPMLAPHSFHELQGLQVLDLSSNpRLQWAGPEVFSGLGSLQELDLSGTGLV-PLPEKL 303
Cdd:PLN00113 200 -LVGQIPRELGQMKSLKWIYLGYN-NLSGEIPYEIGGLTSLNHLDLVYNNLTgPIPSSL 256
LRR_8 pfam13855
Leucine rich repeat;
189-243 7.48e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.20  E-value: 7.48e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 741952451  189 PTIQSLNLAWNRLRAVPD--LRGLP-LRYLSLDGNPLAAIGPGAFEGLAGLTHLSLGS 243
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDgaFKGLSnLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSG 58
LRR_8 pfam13855
Leucine rich repeat;
259-313 9.57e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.82  E-value: 9.57e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 741952451  259 QGLQVLDLSSNpRLQWAGPEVFSGLGSLQELDLSGTGLVPLPEKLLVHLPALQSI 313
Cdd:pfam13855   1 PNLRSLDLSNN-RLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYL 54
LRR_8 pfam13855
Leucine rich repeat;
113-174 1.63e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.04  E-value: 1.63e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 741952451  113 RYLESLDLSHNGLAALPTGSFTS-SPLSDVNLSHNRLREVSVSAFATHSQGRALhvDLSHNLL 174
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGlSNLKVLDLSNNLLTTLSPGAFSGLPSLRYL--DLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 43-296 3.82e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 41.96  E-value: 3.82e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741952451  43 SLTRVGCSGLGPHIVPVPiplDTAHLDLSSNRLETVNESV-LAGPGYTTLSGL---DLSYNLLTSLSPTAFSRLR---YL 115
Cdd:cd00116   34 TLGEEAAKALASALRPQP---SLKELCLSLNETGRIPRGLqSLLQGLTKGCGLqelDLSDNALGPDGCGVLESLLrssSL 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741952451 116 ESLDLSHNGLAALPT----GSFTSSP--LSDVNLSHNRLrevsvsafaTHSQGRALHVDLSHNllqrllphssragqpaP 189
Cdd:cd00116  111 QELKLNNNGLGDRGLrllaKGLKDLPpaLEKLVLGRNRL---------EGASCEALAKALRAN----------------R 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741952451 190 TIQSLNLAWNRLR--AVPDL-RGLP----LRYLSLDGNPLAAIGPGAFEGLaglthlslgslqglpmlaphsFHELQGLQ 262
Cdd:cd00116  166 DLKELNLANNGIGdaGIRALaEGLKancnLEVLDLNNNGLTDEGASALAET---------------------LASLKSLE 224

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 741952451 263 VLDLSSNPRLQWAGPEVFSGLG----SLQELDLSGTGL 296
Cdd:cd00116  225 VLNLGDNNLTDAGAAALASALLspniSLLTLSLSCNDI 262
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 84-201 4.77e-04

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 41.70  E-value: 4.77e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741952451  84 AGPGYTTLSGLDLSYNLLTSLSPTAFSRL----RYLESLDLSHN-----GLAALPTGSFTSSPLSDVNLSHNRLREVSVS 154
Cdd:COG5238  231 ALKGNKSLTTLDLSNNQIGDEGVIALAEAlknnTTVETLYLSGNqigaeGAIALAKALQGNTTLTSLDLSVNRIGDEGAI 310

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 741952451 155 AFATHSQGRA-LHV-DLSHN---------LLQRLlphssragQPAPTIQSLNLAWNRL 201
Cdd:COG5238  311 ALAEGLQGNKtLHTlNLAYNgigaqgaiaLAKAL--------QENTTLHSLDLSDNQI 360
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
67-217 1.21e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 40.69  E-value: 1.21e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741952451  67 HLDLSSNRLETVNEsvLAGPgyTTLSGLDLSYNLLTSLSPTAfsRLRYLESLDLSHNGLAALPTGSFTSSPLSDVNLSHN 146
Cdd:COG4886  232 TLDLSNNQLTDLPE--LGNL--TNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLL 305

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 741952451 147 RLREVSVSAFATHSQGRALHVDLSHNLLQRLLPHSSRAGQPAPTIQSLNLAWNRLRAVPDLRGLPLRYLSL 217
Cdd:COG4886  306 LLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLE 376
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 68-307 1.76e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 40.16  E-value: 1.76e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741952451  68 LDLSSNRLETVNESVLAG--PGYTTLSGLDLSYNLLTSLSPTAF----SRLRYLESLDLSHN-----GLAALPTGSFTSS 136
Cdd:COG5238  185 VYLGCNQIGDEGIEELAEalTQNTTVTTLWLKRNPIGDEGAEILaealKGNKSLTTLDLSNNqigdeGVIALAEALKNNT 264

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741952451 137 PLSDVNLSHNRLREVSVSAFATHSQGRalhvdlshnllqrllphssragqpaPTIQSLNLAWNRLRAvpdlRGlplryls 216
Cdd:COG5238  265 TVETLYLSGNQIGAEGAIALAKALQGN-------------------------TTLTSLDLSVNRIGD----EG------- 308

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741952451 217 ldgnpLAAIGPGaFEGLAGLTHLSLGS----LQGLPMLAPHsFHELQGLQVLDLSSNpRLQWAGPEVFS----GLGSLQE 288
Cdd:COG5238  309 -----AIALAEG-LQGNKTLHTLNLAYngigAQGAIALAKA-LQENTTLHSLDLSDN-QIGDEGAIALAkyleGNTTLRE 380

                        250       260
                 ....*....|....*....|
gi 741952451 289 LDLSGTGLVPL-PEKLLVHL 307
Cdd:COG5238  381 LNLGKNNIGKQgAEALIDAL 400
LRR_8 pfam13855
Leucine rich repeat;
138-201 5.25e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 34.81  E-value: 5.25e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 741952451  138 LSDVNLSHNRLREVSVSAFathSQGRAL-HVDLSHNLLQRLLPHSSragQPAPTIQSLNLAWNRL 201
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAF---KGLSNLkVLDLSNNLLTTLSPGAF---SGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 67-129 8.74e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 37.07  E-value: 8.74e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 741952451  67 HLDLSSNRLETVNE-SVLagpgyTTLSGLDLSYNLLTSLSPTA--FSRLRYLESLDLSHNGLAALP 129
Cdd:cd21340  124 VLNISGNNIDSLEPlAPL-----RNLEQLDASNNQISDLEELLdlLSSWPSLRELDLTGNPVCKKP 184
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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